The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-964837" ], "output_participant_list": [ "R-ALL-964752" ], "enzyme_list": [ "A0AAA9SXF2-1", "E1BGJ4-1" ], "evidence": [ { "id": "R-BTA-975814", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975814" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-964752", "participant_name": "Man [Golgi lumen]", "crossref": [ { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000003830679", "database": "ZINC", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "ZINC000003860903", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-964837", "participant_name": "(GlcNAc)3 (Man)5 (Asn)1 [Golgi lumen]", "crossref": [ { "id": "60625", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SXF2", "gene_name": "MAN2A1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "A0AAA9SXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF2" } ] } ] }, { "uniprot_ac": "E1BGJ4", "gene_name": "MAN2A2", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1BGJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGJ4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF2" }, { "id": "SM00872", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00872" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase family 38 central", "eco_id": "ECO_0000259", "start_pos": 503, "end_pos": 589, 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"database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 223, "end_pos": 288, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SYM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYM7" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 129, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 260 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 390, "end_pos": 392 }, { "start_pos": 442, "end_pos": 444 }, { "start_pos": 443, "end_pos": 445 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWW0-1", "uniprot_ac": "A0AAA9SWW0", "uniprot_id": "A0AAA9SWW0_BOVIN", "mass": { "chemical_mass": 128592.0, "monoisotopic_mass": 128592.0 }, "refseq": {}, "gene_names": [ { "name": "TSC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ] } ], "protein_names": [ { "name": "TSC complex subunit 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0", "locus": { "chromosome": "11", "start_pos": 102927412, "end_pos": 102959772, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005190", "url": "https://www.ensembl.org/id/ENSBTAG00000005190" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005190", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005190", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533440", "url": "https://www.ncbi.nlm.nih.gov/gene/533440", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MM99", "url": "https://www.orthodb.org/?gene=F1MM99", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15154:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15154:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-165181", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165181", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380972", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S643", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S643", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S643-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S643-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P787", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P787", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P787-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P787-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM99", "url": "https://www.uniprot.org/uniprotkb/F1MM99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM99-1", "url": "https://www.uniprot.org/uniprotkb/F1MM99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQQANIGELLSMLDSPLLSVRDDVTTVFKENLNSDRGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKMNEYVGKAASRLSALLLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVIVLTTGVLVLITMLPMIPQSGKQHLHDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQATLWSPSAVCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPPCHSDDCVHLSLPQATAPKKEERTDSARPCLHRQPHVPNDRGLEELHGGKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAEPLVPRGGFDSPFYRDSLPGCPRKTLSASSSTQGTSANPEPLNSSLDKSGPDTPKQAFTPIDLPCGGTGESPAGNRERQASLEASILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKTAHHFVSKKTEELLKKAKGSAEEDFTPSASPMEVLDRLIQQGADVHSKELNRLSLPSKSVDWTHFGGSPPSDEICTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRASALEEHNAAMKDQLKLQEKDIQIWKISLQKEQARYNQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTCQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGKLEKDGLLKKLEEQKPEAAEAAEERLDYCQDGCSDSVTGHNEEAPGRNGETKPSRPGGARGGGGGGGRGGGSSSELSTPEKPPNPRAGPFSSRWETVVGEPTSGTPTTVGSLPSSESFLGMKARELFRNKSESQCDEDGLTVGSLSETLKTELGKDSGVEARAPLTLDGPLLPAPKPDSVGQLRIMDYNEAQLEHS", "length": 1160, "header": "tr|A0AAA9SWW0-1|A0AAA9SWW0_BOVIN Isoform 1 of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=1 CANONICAL=A0AAA9SWW0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S643-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#A0AAA9S643-1", "sequence": { "sequence": "MAQQANIGELLSMLDSPLLSVRDDVTTVFKENLNSDRGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKMDTDVIVLTTGVLVLITMLPMIPQSGKQHLHDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQATLWSPSAVCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPPCHSDDCVHLSLPQATAPKKEERTDSARPCLHRQPHVPNDRGLEELHGGKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAEPLVPRGGFDSPFYRDSLPGCPRKTLSASSSTQGTSANPEPLNSSLDKSGPDTPKQAFTPIDLPCGGTGESPAGNRERQASLEASILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKTAHHFVSKKTEELLKKAKGSAEEDFTPSASPMEVLDRLIQQGADVHSKELNRLSLPSKSVDWTHFGGSPPSDEICTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRASALEEHNAAMKDQLKLQEKDIQIWKISLQKEQARYNQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTCQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGKLEKDGLLKKLEEQKPEAAEAAEERLDYCQDGCSDSVTGHNEEAPGRNGETKPSRPGGARGGGGGGGRGGGSSSELSTPEKPPNPRAGPFSSRWETVVGEPTSGTPTTVGSLPSSESFLGMKARELFRNKSESQCDEDGLTVGSLSETLKTELGKDSGVEARAPLTLDGPLLPAPKPDSVGQLRIMDYNEAQLEHS", "length": 1109, "header": "tr|A0AAA9S643-1|A0AAA9SWW0_BOVIN Computationally mapped isoform of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=1 CANONICAL=A0AAA9SWW0-1" }, "locus": { "chromosome": "11", "start_pos": 102959690, "end_pos": 102928416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088500.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088500.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094386.1" } ] } }, { "isoform_ac": "A0AAA9SF59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#A0AAA9SF59-1", "sequence": { "sequence": "MAQQANIGELLSMLDSPLLSVRDDVTTVFKENLNSDRGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKMNEYVGKAASRLSALLLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVIVLTTGVLVLITMLPMIPQSGKQHLHDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQVRCELVCLLSSLLAGEAGLRGQV", "length": 365, "header": "tr|A0AAA9SF59-1|A0AAA9SWW0_BOVIN Computationally mapped isoform of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=1 CANONICAL=A0AAA9SWW0-1" }, "locus": { "chromosome": "11", "start_pos": 102959690, "end_pos": 102942911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127034.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127034.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080610.1" } ] } }, { "isoform_ac": "A0AAA9SWW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#A0AAA9SWW0-1", "sequence": { "sequence": "MAQQANIGELLSMLDSPLLSVRDDVTTVFKENLNSDRGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKHLLDKMNEYVGKAASRLSALLLLGHVVRLQPSWKHKLSQAPLLPSLLKCLKMDTDVIVLTTGVLVLITMLPMIPQSGKQHLHDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQATLWSPSAVCGMTTPPTSPGNVPPDLSHPYSKVFGTTAGGKGTPLGTPATSPPPAPPCHSDDCVHLSLPQATAPKKEERTDSARPCLHRQPHVPNDRGLEELHGGKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAEPLVPRGGFDSPFYRDSLPGCPRKTLSASSSTQGTSANPEPLNSSLDKSGPDTPKQAFTPIDLPCGGTGESPAGNRERQASLEASILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKTAHHFVSKKTEELLKKAKGSAEEDFTPSASPMEVLDRLIQQGADVHSKELNRLSLPSKSVDWTHFGGSPPSDEICTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRASALEEHNAAMKDQLKLQEKDIQIWKISLQKEQARYNQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTCQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGKLEKDGLLKKLEEQKPEAAEAAEERLDYCQDGCSDSVTGHNEEAPGRNGETKPSRPGGARGGGGGGGRGGGSSSELSTPEKPPNPRAGPFSSRWETVVGEPTSGTPTTVGSLPSSESFLGMKARELFRNKSESQCDEDGLTVGSLSETLKTELGKDSGVEARAPLTLDGPLLPAPKPDSVGQLRIMDYNEAQLEHS", "length": 1160, "header": "tr|A0AAA9SWW0-1|A0AAA9SWW0_BOVIN Isoform 1 of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=1 CANONICAL=A0AAA9SWW0-1" }, "locus": { "chromosome": "11", "start_pos": 102959690, "end_pos": 102928416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094618.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094618.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088551.1" } ] } }, { "isoform_ac": "A0ABI0P787-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#A0ABI0P787-1", "sequence": { "sequence": "MAQQANIGELLSMLDSPLLSVRDDVTTVFKENLNSDRGPMLVNTLVDYYLETNSQPVLHILTTLQEPHDKMDTDVIVLTTGVLVLITMLPMIPQSGKQHLHDFFDIFGRLSSWCLKKPGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQEERTDSARPCLHRQPHVPNDRGLEELHGGKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAEPLVPRGGFDSPFYRDSLPGCPRKTLSASSSTQGTSANPEPLNSSLDKSGPDTPKQAFTPIDLPCGGTGESPAGNRERQASLEASILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKTAHHFVSKKTEELLKKAKGSAEEDFTPSASPMEVLDRLIQQGADVHSKELNRLSLPSKSVDWTHFGGSPPSDEICTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRASALEEHNAAMKDQLKLQEKDIQIWKISLQKEQARYNQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTCQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGKLEKDGLLKKLEEQKPEAAEAAEERLDYCQDGCSDSVTGHNEEAPGRNGETKPSRPGGARGGGGGGGRGGGSSSELSTPEKPPNPRAGPFSSRWETVVGEPTSGTPTTVGSLPSSESFLGMKARELFRNKSESQCDEDGLTVGSLSETLKTELGKDSGVEARAPLTLDGPLLPAPKPDSVGQLRIMDYNEAQLEHS", "length": 1033, "header": "tr|A0ABI0P787-1|A0ABI0P787_BOVIN Computationally mapped isoform of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=1 CANONICAL=A0AAA9SWW0-1" }, "locus": { "chromosome": "11", "start_pos": 102959690, "end_pos": 102928416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144259.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144259.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107011.1" } ] } }, { "isoform_ac": "F1MM99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0/entry#F1MM99-1", "sequence": { "sequence": "MSARLCGPLQVDGSLSRGQGSHPWISDSGVWYVQIWVLENCSPLLTVFGARRGTHTQKVPLAACVRVCLAHVSRVQLGPPRWISFLGHVTEVYLVHLHASVYALFHRLYGMYPCNFVSFLRSHYSMKENLETFEEVVKPMMEHVRIHPELVTGSKDHELDPRRWKRLETHDVVIECAKISLDPTEASYEDGYSVSHQISARFPHRSADVSASSYVDTQNSYGNATSTPYSTSRLTLNTPGQLPQTLSSPSTRLLAEPPQATLWSPSAVCGMTTPPTSPGNVPPDLSHPYSKVFGTTGGKGTPLGTPATSPPPAPPCHSDDCVHLSLPQATAPKKEERTDSARPCLHRQPHVPNDRGLEELHGGKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISKELSEITTADAEPLVPRGGFDSPFYRDSLPGCPRKTLSASSSTQGTSANPEPLNSSLDKSGPDTPKQAFTPIDLPCGGTGESPAGNRERQASLEASILTPSPCKIPPQRGVGFGSGQPPPYDHLFEVALPKTAHHFVSKKTEELLKKAKGSAEEDFTPSASPMEVLDRLIQQGADVHSKELNRLSLPSKSVDWTHFGGSPPSDEICTLRNQLLLLHNQLLYERFKRQQHALRNRRLLRKVIRASALEEHNAAMKDQLKLQEKDIQIWKISLQKEQARYNQLQEQRDTVVTQLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRVELKKANSKVCHTELLLSQVSQKLSNSESVQQQMEFLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQNQRLDTCQKRILELESHLAKKDHLLLEQKKYLEDVKLQARGQLQAAESRYEAQKRITQVFELEILDLYGKLEKDGLLKKLEEQKPEAAEAAEERLDYCQDGCSDSVTGHNEEAPGRNGETKPSRPGGARGGGGGGGRGGGSSSELSTPEKPPNPRAGPFSSRWETVVGEPTSGTPTTVGSLPSSESFLGMKARELFRNKSESQCDEDGLTVGSLSETLKTELGKDSGVEARAPLTLDGPLLPAPKPDSVGQLRIMDYNEAQLEHS", "length": 1076, "header": "tr|F1MM99-1|F1MM99_BOVIN Computationally mapped isoform of TSC complex subunit 1 OS=Bos taurus OX=9913 GN=TSC1 PE=4 SV=3 CANONICAL=A0AAA9SWW0-1" }, "locus": { "chromosome": "11", "start_pos": 102950561, "end_pos": 102928416, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006842.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006842.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006842.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006842.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-165181", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-165181", "resource": "Reactome", "description": "Inhibition of TSC complex formation by AKT (PKB)" }, { "id": "R-BTA-380972", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380972", "resource": "Reactome", "description": "Energy dependent regulation of mTOR by LKB1-AMPK" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" }, { "id": "R-BTA-8854214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "resource": "Reactome", "description": "TBC/RABGAPs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "TSC1-TSC2 complex", "id": "GO:0033596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033596", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWW0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1093, "end_pos": 1095, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" }, { "start_pos": 888, "end_pos": 890, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1093, "end_pos": 1095 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 534, "end_pos": 536 }, { "start_pos": 788, "end_pos": 790 }, { "start_pos": 888, "end_pos": 890 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZF8-1", "uniprot_ac": "A0AAA9SZF8", "uniprot_id": "A0AAA9SZF8_BOVIN", "mass": { "chemical_mass": 83157.0, "monoisotopic_mass": 83157.0 }, "refseq": { "ac": "XP_005218896", "name": "telomere repeats-binding bouquet formation protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218896" }, "gene_names": [ { "name": "TERB1", "type": "recommended", "evidence": [ { "id": "A0AAA9SZF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ] }, { "name": "TERB1", "type": "synonym", "evidence": [ { "id": "XP_005218896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218896" } ] } ], "protein_names": [ { "name": "Telomere repeats-binding bouquet formation protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9SZF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 79", "type": "synonym", "evidence": [ { "id": "A0AAA9SZF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#names_and_taxonomy" } ] }, { "name": "telomere repeats-binding bouquet formation protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218896" } ] } ], "function": [ { "annotation": "Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU1#function" }, { "database": "UniProtKB", "id": "ARBA00058244", "url": "https://www.uniprot.org/uniprotkb/ARBA00058244#function" }, { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TERB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8", "locus": { "chromosome": "18", "start_pos": 34482309, "end_pos": 34510862, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016438", "url": "https://www.ensembl.org/id/ENSBTAG00000016438" } ] } } ], "crossref": [ { "id": "A0AAA9SZF8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZF8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016438", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016438", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11658", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11658", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100295202", "url": "https://www.ncbi.nlm.nih.gov/gene/100295202", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100295202", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295202", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14014", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14014", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14014:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14014:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005218896", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218896", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7F4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7F4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFE5", "url": "https://www.uniprot.org/uniprotkb/E1BFE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFE5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFE5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTSMESEDTKKIQEVKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSGCIAVGKSLNSRNFSKLLHCCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRRQLSSESTTPGRIKKRRIRKNFTKEEINYLFNGVKKMGNHWNLILWSFPFQQGRKAVDLAHKYHRLTKCPKHVAP", "length": 732, "header": "tr|A0AAA9SZF8-1|A0AAA9SZF8_BOVIN Isoform 1 of Telomere repeats-binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=3 SV=1 CANONICAL=A0AAA9SZF8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7F4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#A0AAA9S7F4-1", "sequence": { "sequence": "MDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSGCIAVGKSLNSRNFSKLLHCCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRRQLSSESTTPGRIIMEPFGKTVAVRQVSGSLSSQKC", "length": 663, "header": "tr|A0AAA9S7F4-1|A0AAA9SZF8_BOVIN Computationally mapped isoform of Telomere repeats-binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=3 SV=1 CANONICAL=A0AAA9SZF8-1" }, "locus": { "chromosome": "18", "start_pos": 34506626, "end_pos": 34483783, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078094.1" } ] } }, { "isoform_ac": "A0AAA9SQU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#A0AAA9SQU1-1", "sequence": { "sequence": "MQTSMESEDTKKIQEVKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSEILLTPRRRRQLSSESTTPGRIKKRRIRKNFTKEEINYLFNGVKKMGNHWNLILWSFPFQQGRKAVDLAHKYHRLTKCPKHVAP", "length": 682, "header": "tr|A0AAA9SQU1-1|A0AAA9SZF8_BOVIN Computationally mapped isoform of Telomere repeats-binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=3 SV=1 CANONICAL=A0AAA9SZF8-1" }, "locus": { "chromosome": "18", "start_pos": 34510842, "end_pos": 34483313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129411.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129411.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086328.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086328.1" } ] } }, { "isoform_ac": "A0AAA9SZF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#A0AAA9SZF8-1", "sequence": { "sequence": "MQTSMESEDTKKIQEVKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSGCIAVGKSLNSRNFSKLLHCCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRRQLSSESTTPGRIKKRRIRKNFTKEEINYLFNGVKKMGNHWNLILWSFPFQQGRKAVDLAHKYHRLTKCPKHVAP", "length": 732, "header": "tr|A0AAA9SZF8-1|A0AAA9SZF8_BOVIN Isoform 1 of Telomere repeats-binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=3 SV=1 CANONICAL=A0AAA9SZF8-1" }, "locus": { "chromosome": "18", "start_pos": 34510842, "end_pos": 34483313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104026.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104026.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091844.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091844.1" } ] } }, { "isoform_ac": "A0AAA9TY78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#A0AAA9TY78-1", "sequence": { "sequence": "MQTSMESEDTKKIQEVKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSGCIAVGKSLNSRNFSKLLHCCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRRQLSSESTTPGRIIMEPFGKTVAVRQRKEEFVKTLPKKK", "length": 696, "header": "tr|A0AAA9TY78-1|A0AAA9TY78_BOVIN Computationally mapped isoform of Telomere repeat binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=4 SV=1 CANONICAL=A0AAA9SZF8-1" }, "locus": { "chromosome": "18", "start_pos": 34510842, "end_pos": 34483459, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101145.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101145.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101621.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101621.1" } ] } }, { "isoform_ac": "E1BFE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8/entry#E1BFE5-1", "sequence": { "sequence": "MQTSMESEDTKKIQEVKTDLNLLLECLKYQMDNAFSQKEALVTIHSICQQNSNAGLYFREIGGLMFVKNLAKSSEHSMVKEAALYTLGAVAEQNVYCQQTLCTSELFEDLTWFLSNSDSNTNLKRMSVYVILVLVSNNRTGQTLVRETGCISVLSQLFKTVLSKYELNLSDESAFQSYQLWSSVCSTLCVCVNNPQNDENQMLCCSLFTHANDWLINCMKAEIIRPICSFIGLTLANNTYVQKYFISVGGLDVLSQVLVQLESDSHKTPFSAKLAVVVTKTVDACIADNPTFGVVLSKYHIVSKLLALLLLDNLDSGEKFSVILTLGHCTEDCEENQYDFFKNNGLPLMIQALTESQSEELNKAATFVLHNCKKITEKLSLSLEEYSFDKNEEHLKDINMKEKNLEDYWKKAKEILHRIEELETEGNEENIKGENYKNNVSSVNINIQDTLKHLHADSSGGVPKAEDKDKSQARKLHGSKSHKVMSKACTNDDQVKMVLRSANPVNACYRESGQNKTLCTANSSCKQNLCEETTSEKKNFVSQSRDHIFKHPTPVAQNTKQHLPVTDPFTLCSDIINKEVISFLETDSCSKMLRYRCSGCIAVGKSLNSRNFSKLLHCCPYQCDRHKVIVEAEDRYKSELRKSLICNKKILLTPRRRRQLSSESTTPGRIRLTVQVYHHFK", "length": 681, "header": "tr|E1BFE5-1|A0AAA9SZF8_BOVIN Computationally mapped isoform of Telomere repeats-binding bouquet formation protein 1 OS=Bos taurus OX=9913 GN=TERB1 PE=3 SV=3 CANONICAL=A0AAA9SZF8-1" }, "locus": { "chromosome": "18", "start_pos": 34510842, "end_pos": 34486498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032367.4", "url": "https://www.ensembl.org/id/ENSBTAT00000032367.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032300.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032300.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100295202", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295202", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "meiotic attachment of telomere to nuclear envelope", "id": "GO:0070197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "pmid": "" }, { "name": "shelterin complex", "id": "GO:0070187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070187", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" }, { "start_pos": 678, "end_pos": 680, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZF8" }, { "id": "SM00717", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00717" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myb-like", "eco_id": "ECO_0000259", "start_pos": 675, "end_pos": 726, "start_aa": "Ile", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 }, { "start_pos": 168, "end_pos": 170 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 439, "end_pos": 441 }, { "start_pos": 515, "end_pos": 517 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 611, "end_pos": 613 }, { "start_pos": 678, "end_pos": 680 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZG5-1", "uniprot_ac": "A0AAA9SZG5", "uniprot_id": "A0AAA9SZG5_BOVIN", "mass": { "chemical_mass": 42407.0, "monoisotopic_mass": 42407.0 }, "refseq": { "ac": "NP_001421858", "name": "RAB6A-GEF complex partner protein 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" }, "gene_names": [ { "name": "RGP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SZG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ] }, { "name": "RGP1", "type": "synonym", "evidence": [ { "id": "NP_001421858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" } ] } ], "protein_names": [ { "name": "RAB6A-GEF complex partner protein 2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" } ] }, { "name": "RAB6A-GEF complex partner protein 2", "type": "synonym", "evidence": [ { "id": "NP_001421858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" } ] }, { "name": "RGP1 homolog, RAB6A GEF complex partner 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SZG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5/entry#names_and_taxonomy" } ] }, { "name": "RGP1 retrograde golgi transport homolog", "type": "synonym", "evidence": [ { "id": "NP_001421858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" } ] }, { "name": "retrograde Golgi transport protein RGP1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001421858", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RGP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5", "locus": { "chromosome": "8", "start_pos": 59922869, "end_pos": 59917005, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011433", "url": "https://www.ensembl.org/id/ENSBTAG00000011433" } ] } } ], "crossref": [ { "id": "A0AAA9SZG5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011433", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539393", "url": "https://www.ncbi.nlm.nih.gov/gene/539393", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR014848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CQVRCVQ", "url": "https://omabrowser.org/oma/group/CQVRCVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MND0", "url": "https://www.orthodb.org/?gene=F1MND0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12507", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12507", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421858", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7W7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MND0", "url": "https://www.uniprot.org/uniprotkb/F1MND0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MND0-1", "url": "https://www.uniprot.org/uniprotkb/F1MND0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI", "length": 391, "header": "tr|A0AAA9SZG5-1|A0AAA9SZG5_BOVIN Isoform 1 of RGP1 homolog, RAB6A GEF complex partner 1 OS=Bos taurus OX=9913 GN=RGP1 PE=4 SV=1 CANONICAL=A0AAA9SZG5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5/entry#A0AAA9S7W7-1", "sequence": { "sequence": "PARRFRPEGTRREVPPLPRPQPRTWPRPGGAGGRGLRGTGARSAAAVPAFRLPALQTWALPSDTVVLNARFLGPHPQARPRHPSLPCEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI", "length": 439, "header": "tr|A0AAA9S7W7-1|A0AAA9SZG5_BOVIN Computationally mapped isoform of RGP1 homolog, RAB6A GEF complex partner 1 OS=Bos taurus OX=9913 GN=RGP1 PE=4 SV=1 CANONICAL=A0AAA9SZG5-1" }, "locus": { "chromosome": "8", "start_pos": 59920865, "end_pos": 59917213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104782.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104782.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079402.1" } ] } }, { "isoform_ac": "A0AAA9SZG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5/entry#A0AAA9SZG5-1", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI", "length": 391, "header": "tr|A0AAA9SZG5-1|A0AAA9SZG5_BOVIN Isoform 1 of RGP1 homolog, RAB6A GEF complex partner 1 OS=Bos taurus OX=9913 GN=RGP1 PE=4 SV=1 CANONICAL=A0AAA9SZG5-1" }, "locus": { "chromosome": "8", "start_pos": 59920865, "end_pos": 59917740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135981.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135981.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089493.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089493.1" } ] } }, { "isoform_ac": "A0AAA9TS93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5/entry#A0AAA9TS93-1", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKAWGCL", "length": 373, "header": "tr|A0AAA9TS93-1|A0AAA9TS93_BOVIN Computationally mapped isoform of RGP1 homolog, RAB6A GEF complex partner 1 OS=Bos taurus OX=9913 GN=RGP1 PE=4 SV=1 CANONICAL=A0AAA9SZG5-1" }, "locus": { "chromosome": "8", "start_pos": 59922223, "end_pos": 59917740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099904.1" } ] } }, { "isoform_ac": "F1MND0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5/entry#F1MND0-1", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVLLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPVEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLTELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHITHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPATWTGPEQVPVDTFSWDLPIKPEASHTFLSVQPASYCYSVRSHIRAI", "length": 394, "header": "tr|F1MND0-1|A0AAA9SZG5_BOVIN Computationally mapped isoform of RGP1 homolog, RAB6A GEF complex partner 1 OS=Bos taurus OX=9913 GN=RGP1 PE=4 SV=1 CANONICAL=A0AAA9SZG5-1" }, "locus": { "chromosome": "8", "start_pos": 59921557, "end_pos": 59917740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015196.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015196.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015196.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015196.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 310, "start_aa": "Thr", "end_pos": 310, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr310", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0C4DHA5-1", "protein_name": "RAB6A-GEF complex partner protein 2", "gene_name": "Rgp1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIEIKAKLLRADSAIYATGERVQCLIEFTHKVFSDEPAASQAVHNANEARSQENLAWASAQLHCYRKTSYSTSAGDRAAELTEMIGRTALDAVTQAPGEVIVATKPKILFCDLRLQPGETKMYFFNEFIPRDGPPTYRGHNIRYFYKITIATQRVKSKVQTLAVPIRVLPIPIISRPDELPVTVETNEELAPTNPFLEKREISELEISWHHLKNVTARRAPKFYRISNKRGFVGRFCLFKPAYKLGEDIVGSLDFDPGVNPRKVRCVQFSVKLQQQELSIRPQPVQNHQLQSQSSTGDDVSSMNSFDMASIASGVLADNLHKSATSASSKVKEAPEPTGKLSTISTSHQVCYATLQTQVVVPIPLHVTPTFRTDLVDVRWRLHFEFVTTTLIDFGIPNPESGELKAPSEMPVETMVWNLPVTVYAANPLQIYAPNQTFNLLIK", "length": 443 }, "evidence": [ { "id": "A0AAA9SZG5", "url": "https://omabrowser.org/oma/group/A0AAA9SZG5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A8I5ZYV2-1", "protein_name": "RGP1 homolog, RAB6A GEF complex partner 1", "gene_name": "Rgp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPTEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVHFPQDEAVAPSSPFLEEDDSGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGTGVAPSVSHVTHARHQESCLHTTRTSFSLPIPLCSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPLEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLVSYAAPGPSTSSITI", "length": 391 }, "evidence": [ { "id": "A0AAA9SZG5", "url": "https://omabrowser.org/oma/group/A0AAA9SZG5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1STB5-1", "protein_name": "RGP1 homolog, RAB6A GEF complex partner 1", "gene_name": "RGP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPESQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPIEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVQFPQDEAVAPSSPFLEEDEGGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGAPSVSHVTHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPTEQPEPVTWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI", "length": 391 }, "evidence": [ { "id": "A0AAA9SZG5", "url": "https://omabrowser.org/oma/group/A0AAA9SZG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BHT7-1", "protein_name": "RAB6A-GEF complex partner protein 2", "gene_name": "Rgp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPTEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVHFPQDEAVAPSSPFLEEDDSGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGTGVAPSVSHVTHARHQESCLHTTRTSFSLPIPLCSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPLEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLVSYAAPGPSTSSITI", "length": 391 }, "evidence": [ { "id": "A0AAA9SZG5", "url": "https://omabrowser.org/oma/group/A0AAA9SZG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92546-1", "protein_name": "RAB6A-GEF complex partner protein 2", "gene_name": "RGP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAWASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCDLRLDPGESKSYSYSEVLPIEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLVLTGLQDVRFPQDEAVAPSSPFLEEDEGGKKDSWLAELAGERLMAATSCRSLHLYNISDGRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGAGGVPSVSHVTHARHQESCLHTTRTSFSLPIPLSSTPGFCTAIVSLKWRLHFEFVTSREPGLVLLPPVEQPEPTTWTGPEQVPVDTFSWDLPIKVLPTSPTLASYAAPGPSTSTITI", "length": 391 }, "evidence": [ { "id": "A0AAA9SZG5", "url": "https://omabrowser.org/oma/group/A0AAA9SZG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Ric1-Rgp1 guanyl-nucleotide exchange factor complex", "id": "GO:0034066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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"field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { 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[] }, { "id": "ENSBTAG00000017427", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017427", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616777", "url": "https://www.ncbi.nlm.nih.gov/gene/616777", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616777", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616777", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QKDVWAQ", "url": "https://omabrowser.org/oma/group/QKDVWAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BKM3", "url": "https://www.orthodb.org/?gene=E1BKM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34034:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34034:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15173", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15173", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687015", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687015", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE01", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE01-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM3", "url": "https://www.uniprot.org/uniprotkb/E1BKM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKM3-1", "url": "https://www.uniprot.org/uniprotkb/E1BKM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCWKTLLLLLLYSDAQATLSHRWTRAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 173, "header": "tr|A0AAA9SZ84-1|A0AAA9SZ84_BOVIN Isoform 1 of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#A0AAA9S9W6-1", "sequence": { "sequence": "GLGLSSFERWKDSRQSRRGGTAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 169, "header": "tr|A0AAA9S9W6-1|A0AAA9SZ84_BOVIN Computationally mapped isoform of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99540362, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105779.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105779.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082096.1" } ] } }, { "isoform_ac": "A0AAA9SE01-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#A0AAA9SE01-1", "sequence": { "sequence": "QRTHCLAVGLDNPVVTDPACLLQHLGAVRSPEAYIHPPQRCLRTGLGAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 195, "header": "tr|A0AAA9SE01-1|A0AAA9SZ84_BOVIN Computationally mapped isoform of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99537311, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081818.1" } ] } }, { "isoform_ac": "A0AAA9SZ84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#A0AAA9SZ84-1", "sequence": { "sequence": "MCWKTLLLLLLYSDAQATLSHRWTRAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 173, "header": "tr|A0AAA9SZ84-1|A0AAA9SZ84_BOVIN Isoform 1 of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99545787, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131037.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131037.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089607.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089607.1" } ] } }, { "isoform_ac": "A0AAA9TKB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#A0AAA9TKB0-1", "sequence": { "sequence": "EKCSRFRHLEVSRDVVRSSQIPAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 170, "header": "tr|A0AAA9TKB0-1|A0AAA9TKB0_BOVIN Computationally mapped isoform of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99540522, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108082.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108082.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096697.1" } ] } }, { "isoform_ac": "A0AAA9TM07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#A0AAA9TM07-1", "sequence": { "sequence": "QKGSQRIQARAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 158, "header": "tr|A0AAA9TM07-1|A0AAA9TM07_BOVIN Computationally mapped isoform of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=1 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99539891, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102606.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102606.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099491.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099491.1" } ] } }, { "isoform_ac": "E1BKM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ84/entry#E1BKM3-1", "sequence": { "sequence": "QQSLAVLIRASPSLPAVLFPAAYRPKRSSTLPLNPVLQSSLEEVELLYEFLLAELEISPDLKISIKDEELASLRKASDFRAVCNDVIPKSIPDIRRLSANLSSRLGILKKEDFERTALTLAYTAYRTALSQGYQKDVWAQSLLSLFRALRHDLMRSSGPRASP", "length": 163, "header": "tr|E1BKM3-1|A0AAA9SZ84_BOVIN Computationally mapped isoform of Family with sequence similarity 180 member A OS=Bos taurus OX=9913 GN=FAM180A PE=4 SV=2 CANONICAL=A0AAA9SZ84-1" }, "locus": { "chromosome": "4", "start_pos": 99542743, "end_pos": 99532573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023166.5", "url": "https://www.ensembl.org/id/ENSBTAT00000023166.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023166.4", "url": "https://www.ensembl.org/id/ENSBTAP00000023166.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616777", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616777", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1WEB5-1", "protein_name": "Family with sequence similarity 180 member A", "gene_name": "FAM180A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MCWKTLLLLLLCYDAQATLSHRWSRAVLFPAAHRPKRSSSVPLNPILQSSLEEVQLLYEFLLAELEIGPDLKISIKDEELASLRKAADFHTICNDVIPKSIPDIRRLSASLSSHPGVLKKEDFERTALTLAYVAYRTALSQGHQKDVWAQALLSLFQALRHDLMRSSGPRASP", "length": 173 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y365-1", "protein_name": "Family with sequence similarity 180 member A", "gene_name": "FAM180A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLWKTLLLLLFYYSAHATVNYRWSRAMLYPAAQRLKRSSAAFLNPVLQNSLEDVVLLYEFLLAELDIDKGQRISIKDEELASLRKAAEFDTICNEVIPKSITEIRRLSSRLSSYPRVLKKEDFERTVLTMVYTAYRAAQSQGHQKGTWAESFVNLYKALKHDLMFPYNKETS", "length": 172 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7F4M7-1", "protein_name": "Protein FAM180A", "gene_name": "Fam180a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPWKALMLLLLFSSTEATESRRWNRAALFPAAHRPKRSLSLPLNPILQTSLEDVELLYELLLAEIDISPDLKISIKDEELASLRKALNFHSICNNIIPKNIPDIRRLSTSLANYPGILKKEDFERTALTLAYAAYRTALSEGHQKDIWAQSLISLFQALRHDLMRSSGPGMSS", "length": 173 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3Z9K6-1", "protein_name": "Family with sequence similarity 180, member A", "gene_name": "Fam180a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPWKVLTILLVLSSAQATACRWSRAALFPAAHRPKRSLSLPLNPVLQTSLEEVELLYELLLAEIEISPDLKISIKDEELASLRKALNFHSICNNIIPKSIPDIRRLSANLANNPGVLKKEDFERIALTLAYTAYRTALSEGHQKDIWAQSLISLFQALRHDLMRSSSPGVPS", "length": 172 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UWF9-1", "protein_name": "Protein FAM180A", "gene_name": "FAM180A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHWKMLLLLLLYYNAEASMCHRWSRAVLFPAAHRPKRSSSLPLNPVLQTSLEEVELLYEFLLAELEISPDLQISIKDEELASLRKASDFRTVCNNVIPKSIPDIRRLSASLSSHPGILKKEDFERTVLTLAYTAYRTALSHGHQKDIWAQSLVSLFQALRHDLMRSSQPGVPP", "length": 173 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BR21-1", "protein_name": "Protein FAM180A", "gene_name": "Fam180a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSWKALTILLVFSSTQATASCRWSRAALFPAAHRPKRSLSLPLNPVLQTSLEEVELLYELLLAEIEISPDLEISIKDEELASLRKALSFHSICNNIIPKRIPDIRRLSANLANHPGILKKEDFERITLTLAYTAYRTALSEGHQKDIWAQSLISLFQALRHDLMRSSSPAVSS", "length": 173 }, "evidence": [ { "id": "A0AAA9SZ84", "url": "https://omabrowser.org/oma/group/A0AAA9SZ84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"MPTVFESISRAVVKEIDTSGETIAVRSLSDADKFHCSYLVKKRRRFFGYQYDKTNLTLKDILECEVPFDMVVPELQGDLPDSGIKPASAALPEDSLPLSHLGNPHNKGQGDNFEILDVVDSKGSLAVKFHPQMTFKIAFHIFQEKNIKLEKSEIPQEFLDSLKNKKLKKELPPSFQSIQAKREDLYLVTETLKTKRTETLKYETQFGFQILLKMFGFQCKHKHQKEVTITPEKVLAYRVKQLVFPSAERMDICFLDKTRSFPEEKDGGSSWLGKSLNLQNFRSIKETVQDMVRVLQDLTLEEQKEALNCFTKCLSSEEELQDLEQRVSEVQCSGELQMNSPANSLISSLFNAAGVLIEARAETIWDVLDALMELSEYRQFVAEVLDKGELRPVKDEVESILEENRCEGPLDVSCDPEARTLCALYVVVSILLQLSEKPTSVSS", "length": 443, "header": "tr|A0AAA9SXQ4-1|A0AAA9SXQ4_BOVIN Isoform 1 of Gasdermin B OS=Bos taurus OX=9913 GN=GSDMB PE=3 SV=1 CANONICAL=A0AAA9SXQ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ4/entry#A0AAA9SXQ4-1", "sequence": { "sequence": 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"MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELAEGPTSVSS", "length": 416 }, "evidence": [ { "id": "A0AAA9SXQ4", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": 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], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZM8-1", "uniprot_ac": "A0AAA9SZM8", "uniprot_id": "A0AAA9SZM8_BOVIN", "mass": { "chemical_mass": 35036.0, "monoisotopic_mass": 35036.0 }, "refseq": {}, "gene_names": [ { "name": "HTATIP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SZM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8" } ] } ], "protein_names": [ { "name": "Protein HTATIP2", "type": "recommended", "evidence": [ { "id": "A0AAA9SZM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HTATIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8", "locus": { "chromosome": "29", "start_pos": 24565833, "end_pos": 24611483, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013419", "url": "https://www.ensembl.org/id/ENSBTAG00000013419" } ] } } ], "crossref": [ { "id": "A0AAA9SZM8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd05250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR016040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14097:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14097:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13460", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13460", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SDH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ38-1", "url": 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"length": 315, "header": "tr|A0AAA9SZM8-1|A0AAA9SZM8_BOVIN Isoform 1 of Protein HTATIP2 OS=Bos taurus OX=9913 GN=HTATIP2 PE=4 SV=1 CANONICAL=A0AAA9SZM8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8/entry#A0AAA9SDH7-1", "sequence": { "sequence": "MAETEALPKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTLDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRKKAGAGEVEARVEELKFDRYSIFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGHSVPVITVVRAMLNNVVRPSDKKKELLDNKAIHDLGKADDSLKP", "length": 196, "header": "tr|A0AAA9SDH7-1|A0AAA9SZM8_BOVIN Computationally mapped isoform of Protein HTATIP2 OS=Bos taurus OX=9913 GN=HTATIP2 PE=4 SV=1 CANONICAL=A0AAA9SZM8-1" }, "locus": { "chromosome": "29", "start_pos": 24579540, "end_pos": 24566611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107104.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107104.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084192.1", "url": 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"https://www.ensembl.org/id/ENSBTAP00000087487.1" } ] } }, { "isoform_ac": "A0AAA9SZM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8/entry#A0AAA9SZM8-1", "sequence": { "sequence": "MQASSAQRVRKNAGERSPEIPDIEVEVSELSTQMGAATCSRRAWAAPSGPTGPHPSGRGEQRYPEVTRKTKSRMAETEALPKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTLDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRKKAGAEGFVRVDRDYVLKSAELAKSGGCKHFNLLSSKGADKSSNFLYLQVKGEVEARVEELKFDRYSIFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGHSVPVITVVRAMLNNVVRPSDKKKELLDNKAIHDLGKADDSLKP", "length": 315, "header": "tr|A0AAA9SZM8-1|A0AAA9SZM8_BOVIN Isoform 1 of Protein HTATIP2 OS=Bos taurus OX=9913 GN=HTATIP2 PE=4 SV=1 CANONICAL=A0AAA9SZM8-1" }, "locus": { "chromosome": "29", "start_pos": 24580280, "end_pos": 24566611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097780.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097780.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090878.1" } ] } }, { "isoform_ac": "A0AAF6DLP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8/entry#A0AAF6DLP7-1", "sequence": { "sequence": "MSRCAALSAAVAAGVAALVAALLLLQPEDVGQGASLSMAETEALPKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTLDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRKKAGAEGFVRVDRDYVLKSAELAKSGGCKHFNLLSSKGADKSSNFLYLQVKGEVEARVEELKFDRYSIFRPGVLLCDRQESRPGEWLVRKFFGSLPESWASGHSVPVITVVRAMLNNVVRPSDKKKELLDNKAIHDLGKADDSLKP", "length": 279, "header": "tr|A0AAF6DLP7-1|A0AAF6DLP7_BOVIN Computationally mapped isoform of Protein HTATIP2 OS=Bos taurus OX=9913 GN=HTATIP2 PE=4 SV=1 CANONICAL=A0AAA9SZM8-1" }, "locus": { "chromosome": "29", "start_pos": 24579987, "end_pos": 24566611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017856.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017856.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017856.4", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9SZM8" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM8" }, { "id": "PF13460", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13460" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NAD(P)-binding", "eco_id": "ECO_0000259", "start_pos": 98, "end_pos": 246, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 51 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXX9-1", "uniprot_ac": "A0AAA9SXX9", "uniprot_id": "A0AAA9SXX9_BOVIN", "mass": { "chemical_mass": 70668.0, "monoisotopic_mass": 70668.0 }, "refseq": { "ac": "XP_002692174", "name": "WW domain-containing adapter protein with coiled-coil isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692174" }, "gene_names": [ { "name": "WAC", "type": "recommended", "evidence": [ { "id": "A0AAA9SXX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ] }, { "name": "WAC", "type": "synonym", "evidence": [ { "id": "XP_002692174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692174" } ] } ], "protein_names": [ { "name": "WW domain-containing adapter protein with coiled-coil", "type": "recommended", "evidence": [ { "id": "A0AAA9SXX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9/entry#names_and_taxonomy" } ] }, { "name": "WW domain-containing adapter protein with coiled-coil isoform X3", "type": "synonym", "evidence": [ { "id": "XP_002692174", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692174" } ] } ], "function": [ { "annotation": "Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.", "evidence": [ { "database": "UniProtKB", "id": "F1MGS0", "url": "https://www.uniprot.org/uniprotkb/F1MGS0#function" }, { "database": "UniProtKB", "id": "ARBA00054335", "url": "https://www.uniprot.org/uniprotkb/ARBA00054335#function" }, { "database": "UniProtKB", "id": "A0AAA9SH35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH35#function" }, { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WAC", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9", "locus": { "chromosome": "13", "start_pos": 36067494, "end_pos": 36144967, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018263", "url": "https://www.ensembl.org/id/ENSBTAG00000018263" } ] } } ], "crossref": [ { "id": "A0AAA9SXX9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018263", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018263", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532597", "url": "https://www.ncbi.nlm.nih.gov/gene/532597", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532597", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532597", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FEPADDW", "url": "https://omabrowser.org/oma/group/FEPADDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGS0", "url": "https://www.orthodb.org/?gene=F1MGS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15911:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15911:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8866654", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002692174", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692174", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SH35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS0", "url": "https://www.uniprot.org/uniprotkb/F1MGS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVMYARKQQRLSDGCHDRRGDAQPYQALKYSSKSHPSSGDHRHEKMRDAADPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHIHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQRTERKESTSGDKAVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 646, "header": "tr|A0AAA9SXX9-1|A0AAA9SXX9_BOVIN Isoform 1 of WW domain-containing adapter protein with coiled-coil OS=Bos taurus OX=9913 GN=WAC PE=4 SV=1 CANONICAL=A0AAA9SXX9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9/entry#A0AAA9SH35-1", "sequence": { "sequence": "MVMYARKQQRLSDGCHDRRGDAQPYQALKYSSKSHPSSGDHRHEKMRDAADPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHIHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGKSTSGDKAVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 543, "header": "tr|A0AAA9SH35-1|A0AAA9SXX9_BOVIN Computationally mapped isoform of WW domain-containing adapter protein with coiled-coil OS=Bos taurus OX=9913 GN=WAC PE=4 SV=1 CANONICAL=A0AAA9SXX9-1" }, "locus": { "chromosome": "13", "start_pos": 36144225, "end_pos": 36068498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098336.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098336.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084647.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084647.1" } ] } }, { "isoform_ac": "A0AAA9SXX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9/entry#A0AAA9SXX9-1", "sequence": { "sequence": "MVMYARKQQRLSDGCHDRRGDAQPYQALKYSSKSHPSSGDHRHEKMRDAADPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHIHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQRTERKESTSGDKAVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNSQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 646, "header": "tr|A0AAA9SXX9-1|A0AAA9SXX9_BOVIN Isoform 1 of WW domain-containing adapter protein with coiled-coil OS=Bos taurus OX=9913 GN=WAC PE=4 SV=1 CANONICAL=A0AAA9SXX9-1" }, "locus": { "chromosome": "13", "start_pos": 36144225, "end_pos": 36068498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088169.1" } ] } }, { "isoform_ac": "F1MGS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9/entry#F1MGS0-1", "sequence": { "sequence": "MRDAADPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHIHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQRTERKESTSGDKAVSHSCTTPSTSSASGLNPTSAPPASASAIPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSNQRSPSPGPNHTSSSNASNTAVVPQNSSARPPCSLTPTLAAHFNENLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 600, "header": "tr|F1MGS0-1|F1MGS0_BOVIN Computationally mapped isoform of WW domain-containing adapter protein with coiled-coil OS=Bos taurus OX=9913 GN=WAC PE=4 SV=4 CANONICAL=A0AAA9SXX9-1" }, "locus": { "chromosome": "13", "start_pos": 36142199, "end_pos": 36068498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024313.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024313.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024313.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024313.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 259, "start_aa": "Thr", "end_pos": 259, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr259", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532597", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532597", "resource": "KEGG Pathway" }, { "id": "R-BTA-8866654", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866654", "resource": "Reactome", "description": "E3 ubiquitin ligases ubiquitinate target proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q924H7-1", "protein_name": "WW domain-containing adapter protein with coiled-coil", "gene_name": "Wac", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVMYARKQQRLSDGCHDRRGDSQPFQALKYSSKSHPSSGDHRHEKMRDAADPSPPNKMLRRSNSPENKYSDSTGHNKAKNVHTQRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKLAVNSFPKDRDYRREVMQATATSGFTSGMEDKHSSDASSLLPQNILSQTSRHNDKDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTASLPAQKTERKESAPGDKSISHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSTIPPLLQDPNLFRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPMKPLISTPPVSSQPKVSTPVVKQGPVSHSATQQPVTADKQQSHDPVSPRSLQRLSSQRSPSPGPNHTCSSNASTATVVPQNASARPACSLTPTLAAHFNDNLIKHVQGWPADHAEKQASRLREEAHNMGSVHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 646 }, "evidence": [ { "id": "A0AAA9SXX9", "url": "https://omabrowser.org/oma/group/A0AAA9SXX9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BTA9-1", "protein_name": "WW domain-containing adapter protein with coiled-coil", "gene_name": "WAC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSLTPALAAHFSENLIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV", "length": 647 }, "evidence": [ { "id": "A0AAA9SXX9", "url": "https://omabrowser.org/oma/group/A0AAA9SXX9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "positive regulation of macroautophagy", "id": "GO:0016239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "mitotic G1 DNA damage checkpoint signaling", "id": "GO:0031571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031571", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "regulation of autophagy", "id": "GO:0010506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXX9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 545, "end_pos": 547, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXX9" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 135, "end_pos": 162, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 259 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 434, "end_pos": 436 }, { "start_pos": 529, "end_pos": 531 }, { "start_pos": 535, "end_pos": 537 }, { "start_pos": 545, "end_pos": 547 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0W6-1", "uniprot_ac": "A0AAA9T0W6", "uniprot_id": "A0AAA9T0W6_BOVIN", "mass": { "chemical_mass": 60801.0, "monoisotopic_mass": 60801.0 }, "refseq": { "ac": "XP_024850003", "name": "nectin-3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850003" }, "gene_names": [ { "name": "NECTIN3", "type": "recommended", "evidence": [ { "id": "A0AAA9T0W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ] }, { "name": "NECTIN3", "type": "synonym", "evidence": [ { "id": "XP_024850003", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850003" } ] } ], "protein_names": [ { "name": "Nectin-3", "type": "recommended", "evidence": [ { "id": "A0AAA9T0W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#names_and_taxonomy" } ] }, { "name": "Nectin cell adhesion molecule 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T0W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#names_and_taxonomy" } ] }, { "name": "Poliovirus receptor-related protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T0W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#names_and_taxonomy" } ] }, { "name": "nectin-3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024850003", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850003" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NECTIN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6", "locus": { "chromosome": "1", "start_pos": 56089185, "end_pos": 55893436, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013769", "url": "https://www.ensembl.org/id/ENSBTAG00000013769" } ] } } ], "crossref": [ { "id": "A0AAA9T0W6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013769", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013769", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05887", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05887", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07704", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07704", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534360", "url": "https://www.ncbi.nlm.nih.gov/gene/534360", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534360", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534360", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MUF6", "url": "https://www.orthodb.org/?gene=F1MUF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23277:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23277:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420597", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420597", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024850003", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850003", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUF6", "url": "https://www.uniprot.org/uniprotkb/F1MUF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUF6-1", "url": "https://www.uniprot.org/uniprotkb/F1MUF6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARTPGPAPLCPGGGKAQLSSASPPGAGLLLPPPTPPPLLLLLFPLLFFSWLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQHGFSVQGEYQGRVLFKNYSINDATITLHNIGFSDSGKYICKAVTFPLGNAESSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIVSQYKLFPTRFAKGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADFKDLATEPKKLPFPLSTLATIKDDTIGTIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEQYDENEDDLVSHVDGSVISRREWYV", "length": 549, "header": "tr|A0AAA9T0W6-1|A0AAA9T0W6_BOVIN Isoform 1 of Nectin-3 OS=Bos taurus OX=9913 GN=NECTIN3 PE=3 SV=1 CANONICAL=A0AAA9T0W6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#A0AAA9SI40-1", "sequence": { "sequence": "MTCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQHGFSVQGEYQGRVLFKNYSINDATITLHNIGFSDSGKYICKAVTFPLGNAESSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIVSQYKLFPTRFAKGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADFKDLATEPKKLPFPLSTLATIKDDTIGTIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEQYDENEDDLVSHVDGSVISRREWYV", "length": 499, "header": "tr|A0AAA9SI40-1|A0AAA9T0W6_BOVIN Computationally mapped isoform of Nectin-3 OS=Bos taurus OX=9913 GN=NECTIN3 PE=3 SV=1 CANONICAL=A0AAA9T0W6-1" }, "locus": { "chromosome": "1", "start_pos": 55963690, "end_pos": 55921404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090588.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090588.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085004.1" } ] } }, { "isoform_ac": "A0AAA9T0W6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#A0AAA9T0W6-1", "sequence": { "sequence": "MARTPGPAPLCPGGGKAQLSSASPPGAGLLLPPPTPPPLLLLLFPLLFFSWLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQHGFSVQGEYQGRVLFKNYSINDATITLHNIGFSDSGKYICKAVTFPLGNAESSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIVSQYKLFPTRFAKGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADFKDLATEPKKLPFPLSTLATIKDDTIGTIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEQYDENEDDLVSHVDGSVISRREWYV", "length": 549, "header": "tr|A0AAA9T0W6-1|A0AAA9T0W6_BOVIN Isoform 1 of Nectin-3 OS=Bos taurus OX=9913 GN=NECTIN3 PE=3 SV=1 CANONICAL=A0AAA9T0W6-1" }, "locus": { "chromosome": "1", "start_pos": 55963690, "end_pos": 55893635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132201.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132201.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090196.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090196.1" } ] } }, { "isoform_ac": "F1MUF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6/entry#F1MUF6-1", "sequence": { "sequence": "MARTPGPAPLCPGGGKAQLSSASPPGAGLLLPPPTPPPLLLLLFPLLFFSWLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQHGFSVQGEYQGRVLFKNYSINDATITLHNIGFSDSGKYICKAVTFPLGNAESSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIVSQYKLFPTRFAKGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADFKDLATEPKKLPFPLSTLATIKDDTIGTIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEQYDENEDDLVSHVDGSVISRRE", "length": 546, "header": "tr|F1MUF6-1|F1MUF6_BOVIN Computationally mapped isoform of Nectin-3 OS=Bos taurus OX=9913 GN=NECTIN3 PE=3 SV=4 CANONICAL=A0AAA9T0W6-1" }, "locus": { "chromosome": "1", "start_pos": 55963683, "end_pos": 55893635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032332.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032332.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032266.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032266.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 35, "start_aa": "Thr", "end_pos": 35, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr35", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:534360", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534360", "resource": "KEGG Pathway" }, { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" }, { "id": "R-BTA-420597", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420597", "resource": "Reactome", "description": "Nectin/Necl trans heterodimerization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "symbiont entry into host cell", "id": "GO:0046718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046718", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" }, { "name": "cell adhesion mediator activity", "id": "GO:0098631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0W6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T0W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 165, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 35 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 222, "end_pos": 224 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"A0AAA9SZK9_BOVIN", "mass": { "chemical_mass": 32727.0, "monoisotopic_mass": 32727.0 }, "refseq": { "ac": "XP_059741972", "name": "GTPase IMAP family member 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741972" }, "gene_names": [ { "name": "GIMAP1", "type": "recommended", "evidence": [ { "id": "A0AAA9SZK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" } ] }, { "name": "GIMAP1", "type": "synonym", "evidence": [ { "id": "XP_059741972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741972" } ] } ], "protein_names": [ { "name": "GTPase IMAP family member 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059741972", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741972" } ] }, { "name": "GTPase, IMAP family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SZK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GIMAP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SZK9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZK9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037510", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037510", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01852", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01852", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615733", "url": "https://www.ncbi.nlm.nih.gov/gene/615733", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059741972", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741972", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SK91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P005", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P005", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P005-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P005-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1D0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1D0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B822", "url": "https://www.uniprot.org/uniprotkb/E1B822", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B822-1", "url": "https://www.uniprot.org/uniprotkb/E1B822-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 298, "header": "tr|A0AAA9SZK9-1|A0AAA9SZK9_BOVIN Isoform 1 of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=1 CANONICAL=A0AAA9SZK9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#A0AAA9SK91-1", "sequence": { "sequence": "MGQQESDCRNTNSFGLSSGQICPLSPLARERLFTQPLPLLFLPCWCQMGLNTVTCRKQVIMGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 358, "header": "tr|A0AAA9SK91-1|A0AAA9SZK9_BOVIN Computationally mapped isoform of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=1 CANONICAL=A0AAA9SZK9-1" }, "locus": { "chromosome": "4", "start_pos": 113317365, "end_pos": 113314183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126171.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126171.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084293.1" } ] } }, { "isoform_ac": "A0AAA9SZK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#A0AAA9SZK9-1", "sequence": { "sequence": "MGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 298, "header": "tr|A0AAA9SZK9-1|A0AAA9SZK9_BOVIN Isoform 1 of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=1 CANONICAL=A0AAA9SZK9-1" }, "locus": { "chromosome": "4", "start_pos": 113317365, "end_pos": 113315527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093800.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093800.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089730.1" } ] } }, { "isoform_ac": "A0ABI0P005-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#A0ABI0P005-1", "sequence": { "sequence": "MNKLCLGFFQVIMGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 310, "header": "tr|A0ABI0P005-1|A0ABI0P005_BOVIN Computationally mapped isoform of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=1 CANONICAL=A0AAA9SZK9-1" }, "locus": { "chromosome": "4", "start_pos": 113317365, "end_pos": 113315491, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138981.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138981.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104029.1" } ] } }, { "isoform_ac": "A0ABI0P1D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#A0ABI0P1D0-1", "sequence": { "sequence": "MKAVPLVIMGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 306, "header": "tr|A0ABI0P1D0-1|A0ABI0P1D0_BOVIN Computationally mapped isoform of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=1 CANONICAL=A0AAA9SZK9-1" }, "locus": { "chromosome": "4", "start_pos": 113317365, "end_pos": 113307986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105222.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105222.1" } ] } }, { "isoform_ac": "E1B822-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9/entry#E1B822-1", "sequence": { "sequence": "MKAVPLAYRSCESQRLPLCRVEGNSLPHSKLKGKQRSGPSWITGESLSPGKVIMGGRKMPRDEENAYGFQEFRSALQERRLRLLLAGRSGTGKSATGNSILQRKHFLSRLATTAVTRACATGSCCWASWDVEVLDTPDLFSPEVAQADPGFKERGRCYLLSAPGPHAVLLVTQLGRFTAQDLQAWRGVKALFGAGIAAHAVVVFTRREDLDGGSLQQYVRDTDNRALRELVAECGGRCCAFDNRAADGEREAQVGELMGLVEELVRDHGGAPYTNDVYRLAQTLGGLSPEERLRRVAERLAARARTWPLAGLWRWPKAGLGTRCKLGLAALLGALFLLYLLCRRRPEAVTV", "length": 351, "header": "tr|E1B822-1|E1B822_BOVIN Computationally mapped isoform of GTPase, IMAP family member 1 OS=Bos taurus OX=9913 GN=GIMAP1 PE=3 SV=4 CANONICAL=A0AAA9SZK9-1" }, "locus": { "chromosome": "4", "start_pos": 113317365, "end_pos": 113307986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055206.5", "url": "https://www.ensembl.org/id/ENSBTAT00000055206.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052294.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052294.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 63, "start_aa": "Thr", "end_pos": 63, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr63", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK9" }, { "id": "PS51720", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51720" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AIG1-type G", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 229, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 63 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SX47-1", "uniprot_ac": "A0AAA9SX47", "uniprot_id": "A0AAA9SX47_BOVIN", "mass": { "chemical_mass": 26387.0, "monoisotopic_mass": 26387.0 }, "refseq": {}, "gene_names": [ { "name": "LYG2", "type": "recommended", "evidence": [ { "id": "A0AAA9SX47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ] } ], "protein_names": [ { "name": "Lysozyme g-like protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SX47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May act as a potent antibacterial protein that may play a role in the innate immunity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TIZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ4#function" }, { "database": "UniProtKB", "id": "ARBA00054346", "url": "https://www.uniprot.org/uniprotkb/ARBA00054346#function" }, { "database": "UniProtKB", "id": "A0AAA9SKC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC2#function" }, { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47", "locus": { "chromosome": "11", "start_pos": 4366150, "end_pos": 4377072, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068703", "url": "https://www.ensembl.org/id/ENSBTAG00000068703" } ] } } ], "crossref": [ { "id": "A0AAA9SX47", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SX47", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01021", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01021", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31698", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31698", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31698:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31698:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SKC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRSSILAWEIPQTEEPGAVGYEPPPTMLSFALFGGLFVLIGTSRGSHSFTHTMSPRLHFRLYHGCYGDVMIMETPGIPCDNTRMIACGIRGSEMFAEMDLKALQSYQILIKEIGLRHCVDPALIAAIISRESHGGTILLDGWDHTGLKFGLMQLDKKIHHPVGTWDGKEHLLQAVGILTDSIKAIQKKFPSWSVAQHLKGGLSAFKSGTEAIATSADIQADYVNDVLARAKFYKKRGF", "length": 240, "header": "tr|A0AAA9SX47-1|A0AAA9SX47_BOVIN Isoform 1 of Lysozyme g-like protein 2 OS=Bos taurus OX=9913 GN=LYG2 PE=3 SV=1 CANONICAL=A0AAA9SX47-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47/entry#A0AAA9SKC2-1", "sequence": { "sequence": "MLLLSASHGNPHSLKKCTSRGSHSFTHTMSPRLHFRLYHGCYGDVMIMETPGIPCDNTRMIACGIRGSEMFAEMDLKALQSYQILIKEIGLRHCVDPALIAAIISRESHGGTILLDGWDHTGLKFGLMQLDKKIHHPVGTWDGKEHLLQAVGILTDSIKAIQKKFPSWSVAQHLKGGLSAFKSGTEAIATSADIQADYVNDVLARAKFYKKRGF", "length": 214, "header": "tr|A0AAA9SKC2-1|A0AAA9SX47_BOVIN Computationally mapped isoform of Lysozyme g-like protein 2 OS=Bos taurus OX=9913 GN=LYG2 PE=3 SV=1 CANONICAL=A0AAA9SX47-1" }, "locus": { "chromosome": "11", "start_pos": 4373992, "end_pos": 4368227, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102695.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102695.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085748.1" } ] } }, { "isoform_ac": "A0AAA9SX47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47/entry#A0AAA9SX47-1", "sequence": { "sequence": "MATRSSILAWEIPQTEEPGAVGYEPPPTMLSFALFGGLFVLIGTSRGSHSFTHTMSPRLHFRLYHGCYGDVMIMETPGIPCDNTRMIACGIRGSEMFAEMDLKALQSYQILIKEIGLRHCVDPALIAAIISRESHGGTILLDGWDHTGLKFGLMQLDKKIHHPVGTWDGKEHLLQAVGILTDSIKAIQKKFPSWSVAQHLKGGLSAFKSGTEAIATSADIQADYVNDVLARAKFYKKRGF", "length": 240, "header": "tr|A0AAA9SX47-1|A0AAA9SX47_BOVIN Isoform 1 of Lysozyme g-like protein 2 OS=Bos taurus OX=9913 GN=LYG2 PE=3 SV=1 CANONICAL=A0AAA9SX47-1" }, "locus": { "chromosome": "11", "start_pos": 4375541, "end_pos": 4368227, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120419.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120419.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088662.1" } ] } }, { "isoform_ac": "A0AAA9TIZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47/entry#A0AAA9TIZ4-1", "sequence": { "sequence": "MRWLDGITDSMDMSLSAVGYEPPPTMLSFALFGGLFVLIGTSRGSHSFTHTMSPRLHFRLYHGCYGDVMIMETPGIPCDNTRMIACGIRGSEMFAEMDLKALQSYQILIKEIGLRHCVDPALIAAIISRESHGGTILLDGWDHTGLKFGLMQLDKKIHHPVGTWDGKEHLLQAVGILTDSIKAIQKKFPSWSVAQHLKGGLSAFKSGTEAIATSADIQADYVNDVLARAKFYKKRGF", "length": 237, "header": "tr|A0AAA9TIZ4-1|A0AAA9TIZ4_BOVIN Computationally mapped isoform of Lysozyme g-like protein 2 OS=Bos taurus OX=9913 GN=LYG2 PE=3 SV=1 CANONICAL=A0AAA9SX47-1" }, "locus": { "chromosome": "11", "start_pos": 4375793, "end_pos": 4368227, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096211.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096211.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lysozyme activity", "id": "GO:0003796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "peptidoglycan catabolic process", "id": "GO:0009253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009253", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SY77-1", "uniprot_ac": "A0AAA9SY77", "uniprot_id": "A0AAA9SY77_BOVIN", "mass": { "chemical_mass": 141535.0, "monoisotopic_mass": 141535.0 }, "refseq": {}, "gene_names": [ { "name": "ZC3H4", "type": "recommended", "evidence": [ { "id": "A0AAA9SY77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ] } ], "protein_names": [ { "name": "Zinc finger CCCH domain-containing protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9SY77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.", "evidence": [ { "database": "UniProtKB", "id": "E1BHZ4", "url": "https://www.uniprot.org/uniprotkb/E1BHZ4#function" }, { "database": "UniProtKB", "id": "ARBA00059523", "url": "https://www.uniprot.org/uniprotkb/ARBA00059523#function" }, { "database": "UniProtKB", "id": "A0AAA9SNC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC8#function" }, { "database": "UniProtKB", "id": "A0AAA9SPS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS2#function" }, { "database": "UniProtKB", "id": "A0AAA9TA30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA30#function" }, { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZC3H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77", "locus": { "chromosome": "18", "start_pos": 54112366, "end_pos": 54150109, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009286", "url": "https://www.ensembl.org/id/ENSBTAG00000009286" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521686", "url": "https://www.ncbi.nlm.nih.gov/gene/521686", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BHZ4", "url": "https://www.orthodb.org/?gene=E1BHZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13119:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13119:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18044", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18044", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22623", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22623", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9930044", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SNC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHZ4", "url": "https://www.uniprot.org/uniprotkb/E1BHZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHZ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGRAAEEEEEEEEKKEGRGRWVSLARSLFLACFLSWPHAFPPPRGARPLSLALALSFLGAMLRGREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1316, "header": "tr|A0AAA9SY77-1|A0AAA9SY77_BOVIN Isoform 1 of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=1 CANONICAL=A0AAA9SY77-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#A0AAA9SNC8-1", "sequence": { "sequence": "MEAAPGTPPPPPSESPPPPSPPPPSTPSPPLCSPDACLATPHLLHRLPLPDDREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1220, "header": "tr|A0AAA9SNC8-1|A0AAA9SY77_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=1 CANONICAL=A0AAA9SY77-1" }, "locus": { "chromosome": "18", "start_pos": 54149783, "end_pos": 54113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084349.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084349.1" } ] } }, { "isoform_ac": "A0AAA9SPS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#A0AAA9SPS2-1", "sequence": { "sequence": "MLGRAAEEEEEEEEKKEGRGRWVSLARSLFLACFLSWPHAFPPPRGARPLSLALALSFLGAMLRGREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1233, "header": "tr|A0AAA9SPS2-1|A0AAA9SY77_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=1 CANONICAL=A0AAA9SY77-1" }, "locus": { "chromosome": "18", "start_pos": 54149551, "end_pos": 54113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105115.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105115.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084921.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084921.1" } ] } }, { "isoform_ac": "A0AAA9SY77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#A0AAA9SY77-1", "sequence": { "sequence": "MLGRAAEEEEEEEEKKEGRGRWVSLARSLFLACFLSWPHAFPPPRGARPLSLALALSFLGAMLRGREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1316, "header": "tr|A0AAA9SY77-1|A0AAA9SY77_BOVIN Isoform 1 of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=1 CANONICAL=A0AAA9SY77-1" }, "locus": { "chromosome": "18", "start_pos": 54149551, "end_pos": 54113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093765.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093765.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089041.1" } ] } }, { "isoform_ac": "A0AAA9TA30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#A0AAA9TA30-1", "sequence": { "sequence": "MPPTFRDTSAAVWEDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1263, "header": "tr|A0AAA9TA30-1|A0AAA9TA30_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=1 CANONICAL=A0AAA9SY77-1" }, "locus": { "chromosome": "18", "start_pos": 54148175, "end_pos": 54113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099555.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099555.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093481.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093481.1" } ] } }, { "isoform_ac": "E1BHZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77/entry#E1BHZ4-1", "sequence": { "sequence": "MGGEAGSTEVPKGSLACVKALEDPEREDGELEEGELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHTTPLPKKSYSKMDSKGYGMYDDYENEQYGEYEGDEEEDMGKDDYDDFTKELNQYRRAKEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGGRGRGRGSVGGDHPEDEEDFYEEEMDYGESEEPMGDEDYDDYSKELSQYRRSKDGRGRGLSRGRGRGSRGRGKGMGRGRGRGGSRGGMNKGGMNDDEDFYDDDMGDGGGSYRRSDHDKPHQQSDKKGKVICKYFVEGRCTWGDHCNFSHDIELPKKRELCKFYITGFCARAENCPYMHGDFPCKLYHTTGNCINGDDCMFSHDPLTEETRELLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPPAPTSPNGRPMQGGPPPPPPPPPPPPGPPQMPLPAHEPLSPQQLQQQQDMYNKKIPSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNMGPPGPMGGPMHPDMHPDMHPDMHPDMHPDMHPDMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPPAQNFYENFYQQQEGMEMEPGLIGDAEDYGHYEELPGEPGEHLFPEHPLEPDSFSEGGPPGRPKPGAGVPDFLPSAQRALYLRIQQKQQEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRPQASVGELSGSGLGDPRLQKGHPTGGRLADPRLSRDPRLSRHAEASSGSGPGDTGPSDPRLARSLPSSKPDGGLHSSPAGPGGSKGSGPPPAEEEEGERALREKAVNIPLEPLPGHPLRDPRSQLQQFSHIKKDVTLSRPSFARTVLWSPEDLIPLPLPKQEAAPPVPAALQSLPALDPRLHRAAASGPPNSRQRAGNSADAGAAGSSLPDFELLSRILKTVNVTGPLATPGSGDKPSDPRVRKTPTDPRLQKPTDSATASSRAAKPGPAEVPSPAASPSGESSPPATAPYDPRVLAAGGLGQGGGGGQSSVLSGISLYDPRTPNAGGKAAEPAADTGAQPKGPEGNGRSSAAAKAKEPPFVRKSALEQPESGKPGADGATATDRYNSYNRPRPKAAAAPAAAVGAPSAEGSLPQPGVHNLPVPTLFGTVKPAPKTGSGSPFAGNSPAQEGEQDAGSLKDVFKGFDPTASPFCQ", "length": 1276, "header": "tr|E1BHZ4-1|E1BHZ4_BOVIN Computationally mapped isoform of Zinc finger CCCH domain-containing protein 4 OS=Bos taurus OX=9913 GN=ZC3H4 PE=3 SV=3 CANONICAL=A0AAA9SY77-1" }, "locus": { "chromosome": "18", "start_pos": 54136468, "end_pos": 54113973, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012237.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012237.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012237.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012237.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1072, "start_aa": "Thr", "end_pos": 1072, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1072", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 530, "start_aa": "Thr", "end_pos": 530, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr530", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 541, "start_aa": "Thr", "end_pos": 541, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr541", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9930044", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9930044", "resource": "Reactome", "description": "Nuclear RNA decay" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of DNA-templated transcription, elongation", "id": "GO:0032785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "DNA-templated transcription termination", "id": "GO:0006353", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006353", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "nuclear RNA surveillance", "id": "GO:0071027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "lncRNA catabolic process", "id": "GO:0110064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "negative regulation of lncRNA transcription", "id": "GO:0140744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140744", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY77" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9SZB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLN4", "url": "https://www.uniprot.org/uniprotkb/F1MLN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSDPAMVAPTMGEMEEYAEGNHPVKVKECPVAPETYIVFPVAKCNVEVKFLLLLTLWLTLLGEAAAQKPPRSGDSGLCPTLEDHIVRVDIRIRRRNQGVFFSRNLQNRSISPWDYNITRDANRFPSEIAEAQCRHMGCINAEGQEDRTLNSVPIQQEFLVLRRKQNGCPGLFQLEKVLVTVGCTCVTPMVRHLHDPMADQVADQLS", "length": 207, "header": "tr|A0AAA9SZB9-1|A0AAA9SZB9_BOVIN Isoform 1 of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17F PE=3 SV=1 CANONICAL=A0AAA9SZB9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9/entry#A0AAA9SU55-1", "sequence": { "sequence": "HIRDLKAPLANPFWLKKSNHVQSERAKVKFLLLLTLWLTLLGEAAAQKPPRSGDSGLCPTLEDHIVRVDIRIRRRNQGVFFSRNLQNRSISPWDYNITRDANRFPSEIAEAQCRHMGCINAEGQEDRTLNSVPIQQEFLVLRRKQNGCPGLFQLEKVLVTVGCTCVTPMVRHLHDPMADQVADQLS", "length": 186, "header": "tr|A0AAA9SU55-1|A0AAA9SZB9_BOVIN Computationally mapped isoform of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17F PE=3 SV=1 CANONICAL=A0AAA9SZB9-1" }, "locus": { "chromosome": "23", "start_pos": 24653891, "end_pos": 24646424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120972.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120972.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089958.1" } ] } }, { "isoform_ac": "A0AAA9SZB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9/entry#A0AAA9SZB9-1", "sequence": { "sequence": "MVSDPAMVAPTMGEMEEYAEGNHPVKVKECPVAPETYIVFPVAKCNVEVKFLLLLTLWLTLLGEAAAQKPPRSGDSGLCPTLEDHIVRVDIRIRRRNQGVFFSRNLQNRSISPWDYNITRDANRFPSEIAEAQCRHMGCINAEGQEDRTLNSVPIQQEFLVLRRKQNGCPGLFQLEKVLVTVGCTCVTPMVRHLHDPMADQVADQLS", "length": 207, "header": "tr|A0AAA9SZB9-1|A0AAA9SZB9_BOVIN Isoform 1 of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17F PE=3 SV=1 CANONICAL=A0AAA9SZB9-1" }, "locus": { "chromosome": "23", "start_pos": 24661566, "end_pos": 24646424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099833.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099833.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090765.1" } ] } }, { "isoform_ac": "F1MLN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9/entry#F1MLN4-1", "sequence": { "sequence": "MTMTVLCDTAVVKFLLLLTLWLTLLGEAAAQKPPRSGDSGLCPTLEDHIVRVDIRIRRRNQGVFFSRNLQNRSISPWDYNITRDANRFPSEIAEAQCRHMGCINAEGQEDRTLNSVPIQQEFLVLRRKQNGCPGLFQLEKVLVTVGCTCVTPMVRHLHDPMADQVADQLS", "length": 170, "header": "tr|F1MLN4-1|A0AAA9SZB9_BOVIN Computationally mapped isoform of Interleukin-17A OS=Bos taurus OX=9913 GN=IL17F PE=3 SV=2 CANONICAL=A0AAA9SZB9-1" }, "locus": { "chromosome": "23", "start_pos": 24653127, "end_pos": 24646424, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022393.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022393.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022393.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022393.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", 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], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PD4-1", "protein_name": "Interleukin-17F", "gene_name": "IL17F", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ", "length": 163 }, "evidence": [ { "id": "A0AAA9SZB9", "url": "https://omabrowser.org/oma/group/A0AAA9SZB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 11 ], 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"https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SV22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1I7", "url": "https://www.uniprot.org/uniprotkb/G3N1I7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1I7-1", "url": "https://www.uniprot.org/uniprotkb/G3N1I7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSREEAPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTGHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESHQTNVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREESLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAPKERGPSAAEVFKCVRWTHFTDEDRGYLEELLTKPIVKKYCLDLVEGALQMRYGDMLSKSLVPKPESSSSSSVVSIAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSLAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHGQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARRDPASIPGLRRSPGEGNGNPLKCSCLENSMDRGAWLVIVLGGHSQTRQKDFHSWGFSGGSAVKKLLPNEGDTVSVLDPGGCHIPRSS", "length": 720, "header": "tr|A0AAA9SWN6-1|A0AAA9SWN6_BOVIN Isoform 1 of Kelch repeat and BTB domain containing 7 OS=Bos taurus OX=9913 GN=KBTBD7 PE=4 SV=1 CANONICAL=A0AAA9SWN6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6/entry#A0AAA9SV22-1", "sequence": { "sequence": "MQSREEAPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTGHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESHQTNVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREESLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAPKERGPSAAEVFKCVRWTHFTDEDRGYLEELLTKPIVKKYCLDLVEGALQMRYGDMLSKSLVPKPESSSSSSVVSIAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSLAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHGQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARRASLVAQR", "length": 641, "header": "tr|A0AAA9SV22-1|A0AAA9SWN6_BOVIN Computationally mapped isoform of Kelch repeat and BTB domain containing 7 OS=Bos taurus OX=9913 GN=KBTBD7 PE=4 SV=1 CANONICAL=A0AAA9SWN6-1" }, "locus": { "chromosome": "12", "start_pos": 11414148, "end_pos": 11375984, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122937.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122937.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087816.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087816.1" } ] } }, { "isoform_ac": "A0AAA9SWN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6/entry#A0AAA9SWN6-1", "sequence": { "sequence": "MQSREEAPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTGHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESHQTNVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREESLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAPKERGPSAAEVFKCVRWTHFTDEDRGYLEELLTKPIVKKYCLDLVEGALQMRYGDMLSKSLVPKPESSSSSSVVSIAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSLAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHGQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARRDPASIPGLRRSPGEGNGNPLKCSCLENSMDRGAWLVIVLGGHSQTRQKDFHSWGFSGGSAVKKLLPNEGDTVSVLDPGGCHIPRSS", "length": 720, "header": "tr|A0AAA9SWN6-1|A0AAA9SWN6_BOVIN Isoform 1 of Kelch repeat and BTB domain containing 7 OS=Bos taurus OX=9913 GN=KBTBD7 PE=4 SV=1 CANONICAL=A0AAA9SWN6-1" }, "locus": { "chromosome": "12", "start_pos": 11414148, "end_pos": 11375907, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135912.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135912.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090882.1" } ] } }, { "isoform_ac": "G3N1I7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6/entry#G3N1I7-1", "sequence": { "sequence": "MQSREEAPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTGHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESHQTNVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREESLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAPKERGPSAAEVFKCVRWTHFTDEDRGYLEELLTKPIVKKYCLDLVEGALQMRYGDMLSKSLVPKPESSSSSSVVSIAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSLAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHGQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSSSFSDDEVWVQ", "length": 666, "header": "tr|G3N1I7-1|G3N1I7_BOVIN Computationally mapped isoform of Kelch repeat and BTB domain containing 7 OS=Bos taurus OX=9913 GN=KBTBD7 PE=4 SV=3 CANONICAL=A0AAA9SWN6-1" }, "locus": { "chromosome": "12", "start_pos": 11414148, "end_pos": 11412151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052791.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052791.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055731.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055731.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" }, { "name": "regulation of Rac protein signal transduction", "id": "GO:0035020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN6" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 63, "end_pos": 138, "start_aa": "Cys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 172, "end_pos": 174 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYW5-1", "uniprot_ac": "A0AAA9SYW5", "uniprot_id": "A0AAA9SYW5_BOVIN", "mass": { "chemical_mass": 63160.0, "monoisotopic_mass": 63160.0 }, "refseq": {}, "gene_names": [ { "name": "NEK3", "type": "recommended", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase Nek3", "type": "recommended", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#names_and_taxonomy" } ] }, { "name": "Never in mitosis A-related kinase 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5", "locus": { "chromosome": "12", "start_pos": 21551865, "end_pos": 21575181, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020612", "url": "https://www.ensembl.org/id/ENSBTAG00000020612" } ] } } ], "crossref": [ { "id": "A0AAA9SYW5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR44984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44984:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44984:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SV42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PW46", "url": "https://www.uniprot.org/uniprotkb/F6PW46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PW46-1", "url": "https://www.uniprot.org/uniprotkb/F6PW46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHWRRKWQPTPVFLPGESQGRGSLVAAVSGVAQSRTRLKRFSSVYQVGRASGDCGSRPSCAVPSMDGYRVLRVIGEGSFGRALLVQQESSNRMFAMKEIRLPKSLSDTRISRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKHQKGKLFPEDTILHWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQDGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPFQANSWKSLILKICQGSMNPLPSHYSYELQHLIKQMFKKNPSHRPSATTLLSRGSLARLIQKCLPPEIITEYGEQVLEETKKSMHSTPRKKDPSRTRITLENEASTVQREEPGGKCSHTDLESINKNLVESALRRVNREEKARSPGPLRRQWEKHVPGTALRALENASILTSSSTAEDDRGGSVIKYSENNTRKQWLKETSETLLNILKNADLSLAFQTYTIYRPGAEGFLKGPLSEETEASDDVDGGWDSVILDPERLEHGLDEEDTDFEEDDSADWVSELKQRTGWQGVSDG", "length": 559, "header": "tr|A0AAA9SYW5-1|A0AAA9SYW5_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek3 OS=Bos taurus OX=9913 GN=NEK3 PE=3 SV=1 CANONICAL=A0AAA9SYW5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#A0AAA9SV42-1", "sequence": { "sequence": "MIFMKIKHSKHLQLSISPKKHVSSTSFPTTPYQTPTVRKIKPKKQVGRASGDCGSRPSCAVPSMDGYRVLRVIGEGSFGRALLVQQESSNRMFAMKEIRLPKSLSDTRISRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKHQKGKLFPEDTILHWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQDGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPFQANSWKSLILKICQGSMNPLPSHYSYELQHLIKQMFKKNPSHRPSATTLLSRGSLARLIQKCLPPEIITEYGEQVLEETKKSMHSTPRKKDPSRTRITLENEASTVQREEPGGKCSHTDLESINKNLVESALRRVNREEKARSPGPLRRQWEKHVPGTALRALENASILTSSSTAEDDRGGSVIKYSENNTRKQWLKETSETLLNILKNADLSLAFQTYTIYRPGAEGFLKGPLSEETEASDDVDGGWDSVILDPERLEHGLDEEDTDFEEDDSADWVSELKQRTGWQGVSDG", "length": 558, "header": "tr|A0AAA9SV42-1|A0AAA9SYW5_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek3 OS=Bos taurus OX=9913 GN=NEK3 PE=3 SV=1 CANONICAL=A0AAA9SYW5-1" }, "locus": { "chromosome": "12", "start_pos": 21574156, "end_pos": 21552369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109219.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109219.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089204.1" } ] } }, { "isoform_ac": "A0AAA9SYW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#A0AAA9SYW5-1", "sequence": { "sequence": "MHWRRKWQPTPVFLPGESQGRGSLVAAVSGVAQSRTRLKRFSSVYQVGRASGDCGSRPSCAVPSMDGYRVLRVIGEGSFGRALLVQQESSNRMFAMKEIRLPKSLSDTRISRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKHQKGKLFPEDTILHWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQDGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPFQANSWKSLILKICQGSMNPLPSHYSYELQHLIKQMFKKNPSHRPSATTLLSRGSLARLIQKCLPPEIITEYGEQVLEETKKSMHSTPRKKDPSRTRITLENEASTVQREEPGGKCSHTDLESINKNLVESALRRVNREEKARSPGPLRRQWEKHVPGTALRALENASILTSSSTAEDDRGGSVIKYSENNTRKQWLKETSETLLNILKNADLSLAFQTYTIYRPGAEGFLKGPLSEETEASDDVDGGWDSVILDPERLEHGLDEEDTDFEEDDSADWVSELKQRTGWQGVSDG", "length": 559, "header": "tr|A0AAA9SYW5-1|A0AAA9SYW5_BOVIN Isoform 1 of Serine/threonine-protein kinase Nek3 OS=Bos taurus OX=9913 GN=NEK3 PE=3 SV=1 CANONICAL=A0AAA9SYW5-1" }, "locus": { "chromosome": "12", "start_pos": 21573648, "end_pos": 21552369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088563.1" } ] } }, { "isoform_ac": "F6PW46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5/entry#F6PW46-1", "sequence": { "sequence": "MDGYRVLRVIGEGSFGRALLVQQESSNRMFAMKEIRLPKVTAKSLSDTRISRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKHQKGKLFPEDTILHWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQDGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENMPYNNKSDIWSLGCILYELCTLKHPFQANSWKSLILKICQGSMNPLPSHYSYELQHLIKQMFKKNPSHRPSATTLLSRGSLARLIQKCLPPEIITEYGEQVLEETKKSMHSTPRKKDPSRTRITLENEASTVQREEPGGKCSHTDLESINKNLVESALRRVNREEKARSPGPLRRQWEKHVPGTALRALENASILTSSSTAEDDRGGSVIKYSENNTRKQWLKETSETLLNILKNADLSLAFQTYTIYRPGAEGFLKGPLSEETEASDDVDGGWDSVILDPERLEHGLDEEDTDFEEDDSADWVSELKQRTGWQGVSDG", "length": 499, "header": "tr|F6PW46-1|F6PW46_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Nek3 OS=Bos taurus OX=9913 GN=NEK3 PE=3 SV=1 CANONICAL=A0AAA9SYW5-1" }, "locus": { "chromosome": "12", "start_pos": 21572170, "end_pos": 21552369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035783.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035783.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035652.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035652.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": 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ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { 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"uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 321, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" 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"length": 1278, "header": "tr|A0AAA9SYN2-1|A0AAA9SYN2_BOVIN Isoform 1 of KIAA0825 OS=Bos taurus OX=9913 GN=MCTP1 PE=4 SV=2 CANONICAL=A0AAA9SYN2-1" }, "locus": { "chromosome": "7", "start_pos": 93884342, "end_pos": 93522663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127793.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127793.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091563.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091563.2" } ] } }, { "isoform_ac": "F1MS51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYN2/entry#F1MS51-1", "sequence": { "sequence": 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"length": 1202, "header": "tr|F1MS51-1|A0AAA9SYN2_BOVIN Computationally mapped isoform of KIAA0825 OS=Bos taurus OX=9913 GN=MCTP1 PE=4 SV=5 CANONICAL=A0AAA9SYN2-1" }, "locus": { "chromosome": "7", "start_pos": 93884342, "end_pos": 93522663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000923.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000923.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000923.8", "url": "https://www.ensembl.org/id/ENSBTAP00000000923.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1166, "end_pos": 1168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1217, "end_pos": 1219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, 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CANONICAL=A0AAA9SX61-1" }, "locus": { "chromosome": "14", "start_pos": 56507728, "end_pos": 56385156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102819.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102819.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087429.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087429.1" } ] } }, { "isoform_ac": "A0AAA9SX61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61/entry#A0AAA9SX61-1", "sequence": { "sequence": "MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFEECPDGFAALDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKKNKKKKRKLIERAQEQHSVFLATDRANQ", "length": 243, "header": "tr|A0AAA9SX61-1|A0AAA9SX61_BOVIN Isoform 1 of R-spondin-2 OS=Bos taurus OX=9913 GN=RSPO2 PE=3 SV=1 CANONICAL=A0AAA9SX61-1" }, "locus": { "chromosome": "14", "start_pos": 56554872, "end_pos": 56385156, 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"ENSBTAT00000095277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091960.1" } ] } }, { "isoform_ac": "A0AAA9TAS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61/entry#A0AAA9TAS2-1", "sequence": { "sequence": "MSLGAIIRILDRKKRESDPMWQDPVDSVPASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFEECPDGFAALDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKKNKKKKRKLIERAQEQHSVFLATDRANQ", "length": 241, "header": "tr|A0AAA9TAS2-1|A0AAA9TAS2_BOVIN Computationally mapped isoform of R-spondin-2 OS=Bos taurus OX=9913 GN=RSPO2 PE=3 SV=1 CANONICAL=A0AAA9SX61-1" }, "locus": { "chromosome": "14", "start_pos": 56554872, "end_pos": 56447806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102292.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102292.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093982.1" } ] } }, { "isoform_ac": "A0AAA9TSX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61/entry#A0AAA9TSX1-1", "sequence": { "sequence": "MQFRLFSFALIILNCMDYSHCQGNRWRRSKRGCRIENCDSCFSKDFCTKCKVGFYLHRGRCFEECPDGFAALDETMECVGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKKNKKKKRKLIERAQEQHSVFLATDRANQ", "length": 179, "header": "tr|A0AAA9TSX1-1|A0AAA9TSX1_BOVIN Computationally mapped isoform of R-spondin 2 OS=Bos taurus OX=9913 GN=RSPO2 PE=3 SV=1 CANONICAL=A0AAA9SX61-1" }, "locus": { "chromosome": "14", "start_pos": 56554872, "end_pos": 56385156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112972.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112972.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099602.1" } ] } }, { "isoform_ac": "F6RLD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61/entry#F6RLD1-1", "sequence": { "sequence": "MAEYDCSFPKASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFEECPDGFAALDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKKNKKKKRKLIERAQEQHSVFLATDRANQ", "length": 222, "header": "tr|F6RLD1-1|F6RLD1_BOVIN Computationally mapped isoform of R-spondin-2 OS=Bos taurus OX=9913 GN=RSPO2 PE=3 SV=3 CANONICAL=A0AAA9SX61-1" }, "locus": { "chromosome": "14", "start_pos": 56554872, "end_pos": 56412032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018083.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018083.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018083.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018083.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536121", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536121", "resource": "KEGG Pathway" }, { "id": "R-BTA-4641263", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641263", "resource": "Reactome", "description": "Regulation of FZD by ubiquitination" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RDB4-1", "protein_name": "R-spondin-2", "gene_name": "RSPO2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKIGFYLHRGRCFEECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRAPKAKEKKNKKKKRKLIDRAQEQHSVFLATDRANQ", "length": 242 }, "evidence": [ { "id": "A0AAA9SX61", "url": "https://omabrowser.org/oma/group/A0AAA9SX61/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6UXX9-1", "protein_name": "R-spondin-2", "gene_name": "RSPO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDRANQ", "length": 243 }, "evidence": [ { "id": "A0AAA9SX61", "url": "https://omabrowser.org/oma/group/A0AAA9SX61/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BFU0-1", "protein_name": "R-spondin-2", "gene_name": "Rspo2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFCLFSFALIILNCMDYSQCQGNRWRRNKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDRVNQ", "length": 243 }, "evidence": [ { "id": "A0AAA9SX61", "url": "https://omabrowser.org/oma/group/A0AAA9SX61/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "BMP receptor binding", "id": "GO:0070700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "limb development", "id": "GO:0060173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060173", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "positive regulation of Wnt signaling pathway", "id": "GO:0030177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SX61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" }, { "id": "PF15913", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15913" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "R-spondin Fu-CRD", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 141, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SX61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX61" }, { "id": "PF19028", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spondin-like TSP1", "eco_id": "ECO_0000259", "start_pos": 145, "end_pos": 198, "start_aa": "Cys", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T044-1", "uniprot_ac": "A0AAA9T044", "uniprot_id": "A0AAA9T044_BOVIN", "mass": { "chemical_mass": 96652.0, "monoisotopic_mass": 96652.0 }, "refseq": { "ac": "XP_010802168", "name": "dynein regulatory complex protein 11 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802168" }, "gene_names": [ { "name": "IQCA1", "type": "recommended", "evidence": [ { "id": "A0AAA9T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" } ] }, { "name": "IQCA1", "type": "synonym", "evidence": [ { "id": "XP_010802168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802168" } ] }, { "name": "IQCA", "type": "synonym", "evidence": [ { "id": "XP_010802168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802168" } ] } ], "protein_names": [ { "name": "IQ motif containing with AAA domain 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#names_and_taxonomy" } ] }, { "name": "dynein regulatory complex protein 11 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010802168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802168" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T044", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044", "locus": { "chromosome": "3", "start_pos": 115767115, "end_pos": 115967640, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013505", "url": "https://www.ensembl.org/id/ENSBTAG00000013505" } ] } } ], "crossref": [ { "id": "A0AAA9T044", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T044", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013505", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013505", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19506", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19506", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618101", "url": "https://www.ncbi.nlm.nih.gov/gene/618101", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N7C8", "url": "https://www.orthodb.org/?gene=F1N7C8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14690:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14690:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27107", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27107", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010802168", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802168", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWC5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T044", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T044-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7C8", "url": "https://www.uniprot.org/uniprotkb/F1N7C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7C8-1", "url": "https://www.uniprot.org/uniprotkb/F1N7C8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPQQLDIPIPKYFLKEKLEVIKGREKILSQILAESGLDVSAEKYQVKPIPLEEAVKLIQIAERARQGRLRAMFMKQIYLQEYRAKQARLLGDKVADVSAAALRIQKVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKQEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGKKKNKKKKGRKGKKDKDLTVDRTIESLYKELVEEGLLIQALKVSLSDYIGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKDWYAKTPMGKKRALALTGGNKENEKDKGKKEKKGKKEKKKK", "length": 833, "header": "tr|A0AAA9T044-1|A0AAA9T044_BOVIN Isoform 1 of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=1 SV=1 CANONICAL=A0AAA9T044-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#A0AAA9SWC5-1", "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPQQLDIPIPKYFLKEKLEVIKGREKILSQILAESGLDVSAEKYQVKPIPLEEAVKLIQIAERARQGRLRAMFMKQIYLQEYRAKQARLLGDKVADVSAAALRIQKVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKQEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGKKKNKKKKGRKGKKDKDLTVDRTIESLYKELVEEGLLIQALKVSLSDYIGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKN", "length": 793, "header": "tr|A0AAA9SWC5-1|A0AAA9T044_BOVIN Computationally mapped isoform of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=1 SV=1 CANONICAL=A0AAA9T044-1" }, "locus": { "chromosome": "3", "start_pos": 115967357, "end_pos": 115767243, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089109.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089109.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087534.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087534.1" } ] } }, { "isoform_ac": "A0AAA9SY57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#A0AAA9SY57-1", "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPQQLDIPIPKYFLKEKLEVIKGREKILSQILAESGLDVSAEKYQVKPIPLEEAVKLIQIAERARQGRLRAMFMKQIYLQEYRAKQARLLGDKVADVSAAALRIQKVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKQEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKDWYAKTPMGKKRALALTGGNKENEKDKGKKEKKGKKEKKKK", "length": 783, "header": "tr|A0AAA9SY57-1|A0AAA9SY57_BOVIN Computationally mapped isoform of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=4 SV=1 CANONICAL=A0AAA9T044-1" }, "locus": { "chromosome": "3", "start_pos": 115967357, "end_pos": 115779578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099568.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099568.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088254.1" } ] } }, { "isoform_ac": "A0AAA9SYW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#A0AAA9SYW0-1", "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPKYQVKPIPLEEAVKLIQIAERARQGRLRAMFMKQIYLQEYRAKQARLLGDKVADVSAAALRIQKVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGKKKNKKKKGRKGKKDKDLTVDRTIESLYKELVEEGLLIQALKVSLSDYIGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKDWYAKTPMGKKRALALTGGNKENEKDKGKKEKKGKKEKKKK", "length": 792, "header": "tr|A0AAA9SYW0-1|A0AAA9SYW0_BOVIN Computationally mapped isoform of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=4 SV=1 CANONICAL=A0AAA9T044-1" }, "locus": { "chromosome": "3", "start_pos": 115967357, "end_pos": 115779578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111535.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111535.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089464.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089464.1" } ] } }, { "isoform_ac": "A0AAA9T044-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#A0AAA9T044-1", "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPQQLDIPIPKYFLKEKLEVIKGREKILSQILAESGLDVSAEKYQVKPIPLEEAVKLIQIAERARQGRLRAMFMKQIYLQEYRAKQARLLGDKVADVSAAALRIQKVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKQEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGKKKNKKKKGRKGKKDKDLTVDRTIESLYKELVEEGLLIQALKVSLSDYIGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKDWYAKTPMGKKRALALTGGNKENEKDKGKKEKKGKKEKKKK", "length": 833, "header": "tr|A0AAA9T044-1|A0AAA9T044_BOVIN Isoform 1 of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=1 SV=1 CANONICAL=A0AAA9T044-1" }, "locus": { "chromosome": "3", "start_pos": 115967357, "end_pos": 115779578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088872.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088872.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089756.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089756.1" } ] } }, { "isoform_ac": "F1N7C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044/entry#F1N7C8-1", "sequence": { "sequence": "MSNAMYNKMWHQTQEALNSLLDTESQKMMEPQKNQVFIFQMLATFYIKYVQIFRNLENVYDQIVHPQKRILIRKILDAVMGRILELKNEMVELELTEFHYFDDILQDLKLEPQQLDIPIPKYFLKEKLEVIKGREKILSQILAESGLDVSAEVWRGFHQCKRTERQRREEMIFLGMNPPPLFNEVSAAMIQADRLCHLRNKVQIKHEEEYRDALVTIKDDLKLTEGPDIKENLQDQIRHWFIECRNLTGTFPDYPNEEEGGSAIIFSNKTPQQVIDDIVASQDEEEKTKKKKKEKKPKKEKKEKETKETKEKNKQEEEEMWKMSPSVFLHTMEEGNSVYKDLWKNKDESWNFPQDYDPELIKEDKRKELESEIRVQVDELMRQELKNLKLAVNREKELSARTGKKKGGKKKNKKKKGRKGKKDKDLTVDRTIESLYKELVEEGLLIQALKVSLSDYIGEYSYLGTSLRQVSIEPMPSLLDVRQLITLYAILPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSAANITGKYPGKSGLQMMLHVVFKVARKLQPSVVWIGDTEKTFYKKVPHAERKMEPKRLKKQLPKMLKLLKPDDRILIVGTTKRPFDAELQPFCKAYQKIILVPRPDYASRYVLWKEIIQRHGGVITDTLSVSCLAKITDGFTQGHIVQVVKEVLTERRIRQQSHKPLTALEFIASLTSMNPVYQEEEDSFKDWYAKTPMGKKRALALTGGNKENEKDKGKKEKKGKKEKKKK", "length": 769, "header": "tr|F1N7C8-1|F1N7C8_BOVIN Computationally mapped isoform of IQ motif containing with AAA domain 1 OS=Bos taurus OX=9913 GN=IQCA1 PE=4 SV=4 CANONICAL=A0AAA9T044-1" }, "locus": { "chromosome": "3", "start_pos": 115967357, "end_pos": 115779578, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061020.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061020.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053702.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053702.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T044", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T044", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T044", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 599, "end_pos": 601, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T044" }, { "id": "PF00004", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ATPase AAA-type core", "eco_id": "ECO_0000259", "start_pos": 572, "end_pos": 687, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 310, "end_pos": 312 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 599, "end_pos": 601 }, { "start_pos": 604, "end_pos": 606 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }, { "uniprot_canonical_ac": "A0AAA9SWN4-1", "uniprot_ac": "A0AAA9SWN4", "uniprot_id": "A0AAA9SWN4_BOVIN", "mass": { "chemical_mass": 34703.0, "monoisotopic_mass": 34703.0 }, "refseq": { "ac": "NP_001377757", "name": "olfactory receptor family 7 subfamily A member 87", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377757" }, "gene_names": [ { "name": "OR7A87", "type": "recommended", "evidence": [ { "id": "A0AAA9SWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4" } ] }, { "name": "OR7A87", "type": "synonym", "evidence": [ { "id": "NP_001377757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377757" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SWN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 7 subfamily A member 87", "type": "synonym", "evidence": [ { "id": "NP_001377757", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377757" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377757" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7A87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4", "locus": { "chromosome": "7", "start_pos": 9453718, "end_pos": 9454650, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064277", "url": "https://www.ensembl.org/id/ENSBTAG00000064277" } ] } } ], "crossref": [ { "id": "A0AAA9SWN4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "119646115", "url": "https://www.ncbi.nlm.nih.gov/gene/119646115", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:119646115", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:119646115", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377757", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834632", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834632", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHQFVHEIGQKLIRKRPLEAIAESERCVAHLNILNLVILGVGRMLRSGVYIVAGAVAKYIAGPATIISFLVAALFSMLSGLCYAEFGAWVPRSGSVYLYSYVTMGQLYAFVIGWNRILPLVIGTASLARASSYVFDSLIGNHISQALQETFSLHLPYSLATYADFFALGLVLLMTGLLLLGARESILVTKISIGINILVLIFIIITGFVKGDLHNWKLTEQDYKLNTSGSRDIYGLGGLGLLGSGGFAPFGFEGILQGASTCFYCFFGVTAVATKGGEAINPRRSIPWSIMITIFICFLAYSGVSAALTLMVPYHQIQPHDPLPQAILYSWWLPARYFVTIGTLCALISRLQSAMFRMPPLIYMMAKDGLLFRILTRIHVRTGTHVVAIMSAGNLTGVMALLFKLTDLVDLVSVGTLLINSLVAFSVLVLRYQPDQNLSKNENTEEEIEMPDLDEHPLDSEPEARNSNVLKSLWFPISTIPTRKSGQIVYGCASLLVLLMIILSLIVVQWSSQGFSAGSGYTPVAVLLLLLIIGVTVIIWRQPQNPIPLYFKVPALPVLPLVSIFVNIYLMMQITSGTWAIFGIWNVIGFLIYFGYGIRHSLEENDEQQPPASTSQTLDKNTPSPESS", "length": 629, "header": "tr|A0AAA9SWQ6-1|A0AAA9SWQ6_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442239 PE=3 SV=1 CANONICAL=A0AAA9SWQ6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6/entry#A0AAA9SWQ6-1", "sequence": { "sequence": "MLHQFVHEIGQKLIRKRPLEAIAESERCVAHLNILNLVILGVGRMLRSGVYIVAGAVAKYIAGPATIISFLVAALFSMLSGLCYAEFGAWVPRSGSVYLYSYVTMGQLYAFVIGWNRILPLVIGTASLARASSYVFDSLIGNHISQALQETFSLHLPYSLATYADFFALGLVLLMTGLLLLGARESILVTKISIGINILVLIFIIITGFVKGDLHNWKLTEQDYKLNTSGSRDIYGLGGLGLLGSGGFAPFGFEGILQGASTCFYCFFGVTAVATKGGEAINPRRSIPWSIMITIFICFLAYSGVSAALTLMVPYHQIQPHDPLPQAILYSWWLPARYFVTIGTLCALISRLQSAMFRMPPLIYMMAKDGLLFRILTRIHVRTGTHVVAIMSAGNLTGVMALLFKLTDLVDLVSVGTLLINSLVAFSVLVLRYQPDQNLSKNENTEEEIEMPDLDEHPLDSEPEARNSNVLKSLWFPISTIPTRKSGQIVYGCASLLVLLMIILSLIVVQWSSQGFSAGSGYTPVAVLLLLLIIGVTVIIWRQPQNPIPLYFKVPALPVLPLVSIFVNIYLMMQITSGTWAIFGIWNVIGFLIYFGYGIRHSLEENDEQQPPASTSQTLDKNTPSPESS", "length": 629, "header": "tr|A0AAA9SWQ6-1|A0AAA9SWQ6_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC112442239 PE=3 SV=1 CANONICAL=A0AAA9SWQ6-1" }, "locus": { "chromosome": "18", "start_pos": 61418488, "end_pos": 61410874, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092339.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092339.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090902.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 104, "start_aa": "Thr", "end_pos": 104, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr104", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 341, "start_aa": "Thr", "end_pos": 341, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:112442239", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112442239", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ6" }, { "id": "PF13906", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cationic amino acid transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 552, "end_pos": 602, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 104, 341 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 395, "end_pos": 397 }, { "start_pos": 438, "end_pos": 440 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWQ7-1", "uniprot_ac": "A0AAA9SWQ7", "uniprot_id": "A0AAA9SWQ7_BOVIN", "mass": { "chemical_mass": 45934.0, "monoisotopic_mass": 45934.0 }, "refseq": {}, "gene_names": [ { "name": "AADACL3", "type": "recommended", "evidence": [ { "id": "A0AAA9SWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7" } ] } ], "protein_names": [ { "name": "Arylacetamide deacetylase like 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AADACL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7", "locus": { "chromosome": "16", "start_pos": 54778056, "end_pos": 54856765, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015373", "url": "https://www.ensembl.org/id/ENSBTAG00000015373" } ] } } ], "crossref": [ { "id": "A0AAA9SWQ7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWQ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015373", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015373", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530613", "url": "https://www.ncbi.nlm.nih.gov/gene/530613", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530613", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530613", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TLWVICS", "url": "https://omabrowser.org/oma/group/TLWVICS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G5E5I3", "url": "https://www.orthodb.org/?gene=G5E5I3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48081", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48081", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48081:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48081:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07859", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07859", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5I3", "url": "https://www.uniprot.org/uniprotkb/G5E5I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5I3-1", "url": "https://www.uniprot.org/uniprotkb/G5E5I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "RMLISFFLLLLAIACVASVGVGLWVFSNHFLTTDIPAAISHPMRLRVLNCILQLLITWGLIFEKLRICSMPQFVRFVHDLLPLKKHPDVVVKDLQFGTIPVKLYQPKAPASGLRPGIVFYHGGGGILGSLKTYHGICCNLCKKSDAVVLAVGYRMLPKHRFPVILTDCMVGTMHFLKSLDTYGVDPARVIVCGDSVGGSVATVLCQKFVDRSDLPKIRAQILIYSALQGLNFQSPSHQQNKNIPLLNHNLAFYCWCGYLDISPSWISTVLKGAHLPAEVWEKYRKWLSAENIPDKFKKRGYLPMSREPLNEAAYLETKITLDVVNSPLIADDEVVSRLPEACIVSCEYDILRDDSLLYKKRLEDLGVRVTWHHMEDGFHGVLTTADMSFFYFPCSSRILDAVAHFIKGL", "length": 409, "header": "tr|A0AAA9SWQ7-1|A0AAA9SWQ7_BOVIN Isoform 1 of Arylacetamide deacetylase like 3 OS=Bos taurus OX=9913 GN=AADACL3 PE=3 SV=1 CANONICAL=A0AAA9SWQ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7/entry#A0AAA9SWQ7-1", "sequence": { "sequence": "RMLISFFLLLLAIACVASVGVGLWVFSNHFLTTDIPAAISHPMRLRVLNCILQLLITWGLIFEKLRICSMPQFVRFVHDLLPLKKHPDVVVKDLQFGTIPVKLYQPKAPASGLRPGIVFYHGGGGILGSLKTYHGICCNLCKKSDAVVLAVGYRMLPKHRFPVILTDCMVGTMHFLKSLDTYGVDPARVIVCGDSVGGSVATVLCQKFVDRSDLPKIRAQILIYSALQGLNFQSPSHQQNKNIPLLNHNLAFYCWCGYLDISPSWISTVLKGAHLPAEVWEKYRKWLSAENIPDKFKKRGYLPMSREPLNEAAYLETKITLDVVNSPLIADDEVVSRLPEACIVSCEYDILRDDSLLYKKRLEDLGVRVTWHHMEDGFHGVLTTADMSFFYFPCSSRILDAVAHFIKGL", "length": 409, "header": "tr|A0AAA9SWQ7-1|A0AAA9SWQ7_BOVIN Isoform 1 of Arylacetamide deacetylase like 3 OS=Bos taurus OX=9913 GN=AADACL3 PE=3 SV=1 CANONICAL=A0AAA9SWQ7-1" }, "locus": { "chromosome": "16", "start_pos": 54786269, "end_pos": 54779060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094024.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094024.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088671.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088671.1" } ] } }, { "isoform_ac": "G5E5I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7/entry#G5E5I3-1", "sequence": { "sequence": "MLITCVASVGVGLWVFSNHFLTTDIPAAISHPMRLRVLNCILQLLITWGLIFEKLRICSMPQFVRFVHDLLPLKKHPDVVVKDLQFGTIPVKLYQPKAPASGLRPGIVFYHGGGGILGSLKTYHGICCNLCKKSDAVVLAVGYRMLPKHRFPVILTDCMVGTMHFLKSLDTYGVDPARVIVCGDSVGGSVATVLCQKFVDRSDLPKIRAQILIYSALQGLNFQSPSHQQNKNIPLLNHNLAFYCWCGYLDISPSWISTVLKGAHLPAEVWEKYRKWLSAENIPDKFKKRGYLPMSREPLNEAAYLETKITLDVVNSPLIADDEVVSRLPEACIVSCEYDILRDDSLLYKKRLEDLGVRVTWHHMEDGFHGVLTTADMSFFYFPCSSRILDAVAHFIKGL", "length": 399, "header": "tr|G5E5I3-1|G5E5I3_BOVIN Computationally mapped isoform of Arylacetamide deacetylase like 3 OS=Bos taurus OX=9913 GN=AADACL3 PE=3 SV=2 CANONICAL=A0AAA9SWQ7-1" }, "locus": { "chromosome": "16", "start_pos": 54856537, "end_pos": 54779060, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020432.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020432.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020432.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020432.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530613", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530613", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N4H1-1", "protein_name": "Arylacetamide deacetylase-like 3", "gene_name": "Aadacl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVPLALTLLVAAVASFSLGVLLWVICIHFWTEHIPKGITHPVRLRILSCLLHLTLTWGMIFEKLGLCYATQFASFLHDLKPLKRDPDIVVTDLRFGTIPVKLYQPKESSSTLRTGIIFFHGGGTVLGSLRTHHNVCLRLSKDCGSVVLAVGYRKSPKYKYPAMKNDCVAATAQFLKSLHVYGVDPSRVVVCGDSVGGNAATVICQLFRNKADFPQIRAQILIYSSLQSIDFRGPSYQQNANIPLLSWNLAFYCCCCHLDVSTSWKSVIKSGTHLPPEVWEKYRKWLGSENIPERFKKRGYQCIPPGPVNEDAYREITLALNSICSPLIAEDDIVSQLPETCIVSCEYDLLRDHSLLYKKRLEDLGVPVTWHHMEDGFHGVLNTLDFGFLSFPCSSRIMDLVAQFIRKL", "length": 408 }, "evidence": [ { "id": "A0AAA9SWQ7", "url": "https://omabrowser.org/oma/group/A0AAA9SWQ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2A7Z8-1", "protein_name": "Arylacetamide deacetylase-like 3", "gene_name": "Aadacl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVVLALTLLVGSVAVFSLGSLLWVVGKHFWTEHIPEGITHPWRLRILSCLFHLTMTWGMIFEKLGLCYAPQFASFLHDLKPLKRDPDVVVKDLHFGTIPVKLYKPKKPSSIPRLGIIFFHGGGTIIGSLRTHNSICLRLSKECDSVVVSVGYRKSPMYKYPVMKDDCVVATTHFLESLDVYGVDPARVVTCGDSVGGTAATVTSQMLVHRPDLPRIKAQILIYPLLQLIDFGSPSYQQNRNIPLLSWDLAFYCFCCHLDVNISWKSVVKNGMHLPPDVWEKYRKWLGAENIPERFKNRGYKSIPWGPVNNDAYQEIKRSLNYTCSPLISEDSIVSQLPETCIVSCEYDLLRDHSLLYKKRLEDLGVPVTWHHMEDGFHGVLSALDYGLLSFPCASRIMDLIIQFIRKF", "length": 408 }, "evidence": [ { "id": "A0AAA9SWQ7", "url": "https://omabrowser.org/oma/group/A0AAA9SWQ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZCR8-1", "protein_name": "Arylacetamide deacetylase-like 3", "gene_name": "Aadacl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVVLALTLLVDAVAVFLLGSVLWVICRHLWTEHIPEGITHPMRLRVLSCLLQLSLTWGMLFEKLGLCYAPQFASFLHDLMPLKKDPDVVVKDVHFETIPVKLYKPKKPSSVPRIGIIFFHGGGTILGSLRTHHSICLRLSKDCDAVVISVGYRKSPMYKYPVMKDDCVAATTHFLRSLDVYGVDPDRLVVCGDSVGGTAAAVTSQTVVHRKDLPQIRAQILIYPSLQLVDFGSPSYQQNFNVPLLTSNLALYCFCCHLDVKLSWQSVIKSGRHLPPEIWEKYRKWLGVENIPERFKKQGYKPIPRGPVNNEVYQEIKTALNNTCSPLLAEDSLVSQLPETCIVSCEYDLFRDHSLLYKKRLEALGVPVTWHHMEDGFHGVLNTFEFGLLSIPCSLRIMDLIIRFIKKF", "length": 408 }, "evidence": [ { "id": "A0AAA9SWQ7", "url": "https://omabrowser.org/oma/group/A0AAA9SWQ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VUY0-1", "protein_name": "Arylacetamide deacetylase-like 3", "gene_name": "AADACL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWDLALIFLAAACVFSLGVTLWVICSHFFTVHIPAAVGHPVKLRVLHCIFQLLLTWGMIFEKLRICSMPQFFCFMQDLPPLKYDPDVVVTDFRFGTIPVKLYQPKASTCTLKPGIVYYHGGGGVMGSLKTHHGICSRLCKESDSVVLAVGYRKLPKHKFPVPVRDCLVATIHFLKSLDAYGVDPARVVVCGDSFGGAIAAVVCQQLVDRPDLPRIRAQILIYAILQALDLQTPSFQQRKNIPLLTWSFICYFFFQNLDFSSSWQEVIMKGAHLPAEVWEKYRKWLGPENIPERFKERGYQLKPHEPMNEAAYLEVSVVLDVMCSPLIAEDDIVSQLPETCIVSCEYDALRDNSLLYKKRLEDLGVPVTWHHMEDGFHGVLRTIDMSFLHFPCSMRILSALVQFVKGL", "length": 407 }, "evidence": [ { "id": "A0AAA9SWQ7", "url": "https://omabrowser.org/oma/group/A0AAA9SWQ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carboxylic ester hydrolase activity", "id": "GO:0052689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWQ7" }, { "id": "PF07859", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07859" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha/beta hydrolase fold-3", "eco_id": "ECO_0000259", "start_pos": 117, "end_pos": 260, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWR1-1", "uniprot_ac": "A0AAA9SWR1", "uniprot_id": "A0AAA9SWR1_BOVIN", "mass": { "chemical_mass": 44263.0, "monoisotopic_mass": 44263.0 }, "refseq": { "ac": "NP_001178951", "name": "carbohydrate sulfotransferase 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178951" }, "gene_names": [ { "name": "CHST6", "type": "recommended", "evidence": [ { "id": "A0AAA9SWR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1" } ] }, { "name": "CHST6", "type": "synonym", "evidence": [ { "id": "NP_001178951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178951" } ] } ], "protein_names": [ { "name": "Sulfotransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9SWR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9SWR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1/entry#names_and_taxonomy" } ] }, { "name": "carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6", "type": "synonym", "evidence": [ { "id": "NP_001178951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178951" } ] }, { "name": "carbohydrate sulfotransferase 6", "type": "synonym", "evidence": [ { "id": "NP_001178951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178951" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1", "locus": { "chromosome": "18", "start_pos": 2822563, "end_pos": 2841887, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063191", "url": "https://www.ensembl.org/id/ENSBTAG00000063191" } ] } } ], "crossref": [ { "id": "538464", "url": "https://www.ncbi.nlm.nih.gov/gene/538464", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538464", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538464", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDPLMEI", "url": "https://omabrowser.org/oma/group/RDPLMEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLRRVSSTAVTALLLAQTGLLLFLISRPRLPPAASSEERVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWAALSQGSALALHMAVRDLVRSVFLCDMDVFEAYLPWRRNLSDLFQWAESRALCSPPACSAFPRGAISSEAVCKPLCARRPFSLAQEACRSYSHVVLKEVRFFNLQVLYPLLSDPALHLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGKWVEADPELRVVREVCRSHVRIAEAATRKPPPALRGRYRLVRFEDLARAPLPEIRELYAFAGLSLTPQLEAWIHNITHGAGPGARREAFKTTSRDALNVSQAWRHALPFAKIRRVQDLCAGALQLLGYRPVFSEDEQRDLSLDLVLPRGPSSFSWASSTAERPGP", "length": 395, "header": "tr|A0AAA9SWR1-1|A0AAA9SWR1_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=CHST6 PE=3 SV=1 CANONICAL=A0AAA9SWR1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1/entry#A0AAA9SWR1-1", "sequence": { "sequence": "MWLRRVSSTAVTALLLAQTGLLLFLISRPRLPPAASSEERVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWAALSQGSALALHMAVRDLVRSVFLCDMDVFEAYLPWRRNLSDLFQWAESRALCSPPACSAFPRGAISSEAVCKPLCARRPFSLAQEACRSYSHVVLKEVRFFNLQVLYPLLSDPALHLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGKWVEADPELRVVREVCRSHVRIAEAATRKPPPALRGRYRLVRFEDLARAPLPEIRELYAFAGLSLTPQLEAWIHNITHGAGPGARREAFKTTSRDALNVSQAWRHALPFAKIRRVQDLCAGALQLLGYRPVFSEDEQRDLSLDLVLPRGPSSFSWASSTAERPGP", "length": 395, "header": "tr|A0AAA9SWR1-1|A0AAA9SWR1_BOVIN Isoform 1 of Sulfotransferase OS=Bos taurus OX=9913 GN=CHST6 PE=3 SV=1 CANONICAL=A0AAA9SWR1-1" }, "locus": { "chromosome": "18", "start_pos": 2828852, "end_pos": 2827668, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134405.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134405.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089369.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:538464", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538464", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GGK1-1", "protein_name": "Sulfotransferase", "gene_name": "Chst6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLPRFSSTVVLSLLIVQTGILVFLVSRQMPSSPAGRGEHVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWDALSQASAPALHMAVRDLIRSVFLCDMDVFDAYLPWRRNISDLFQWAVSRALCSPPVCDAFARGNISSEEVCKPLCATRPFGLAQEACSSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPRLRVVSEVCRSHVRIAEVALHKPPPFLQDRYRLVRYEDLARDPLTVIRELYAFTGLGLTPQLQTWIYNITHGSGPGARREAFKTTSRDALSVSQAWRHTLPFAKIRRVQELCAGALQLLGYRPVHSELEQRDLSLDLLLPRGMDSFKWASSTDKQPES", "length": 395 }, "evidence": [ { "id": "A0AAA9SWR1", "url": "https://omabrowser.org/oma/group/A0AAA9SWR1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Y1L5-1", "protein_name": "Sulfotransferase", "gene_name": "CHST6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRSRGGSAPSRAPPAAVAPRPRLKAAHCLRRELGSASVPEGGGEVRPTGRGSQGDFCWVRWRRLASFSLSGGTSLLSNPAVGFKAARAGEPAVLPEAGPGLVPASGAVLVPAVLWRWWFLLLLLFFFKSHWRTWLFERRRFRSLELDGEVSFFNCLVRMARIRISSTIITLLVMVQTGFLLFMYTRYNSFTPHSEEKSSQVHILILSSWRSGSSFVGQLFSQHPSVFYLMEPAWHVWVTMYQNSAKVLHMAVRDLVRSVFLCDMSVFDAYMPWKRNLSDLFQWAVSRALCSAPACDSFQRTDVTSEMACKTLCGRYPFSKVEEACKTYSHVVIKEVRFFDLKVLYPLLTDPSLNLKIIHLVRDPRAVVKSREQSVKALARDNGIVLSTNGTKVEDSKYKVMQEICRSHVQIYETATLKPPSFLKDRYLMIRFEDLVRDPLSEISEMYKFADLSLTPTLKSWVYNITHGQGPGKKKEAFKITSRDAVNVSQAWRNVLSFQKIKKIQEVCKGAINMLGYQLVDSEKEQRDLSLDLVLPRRQNQFSWSSFNPKN", "length": 552 }, "evidence": [ { "id": "A0AAA9SWR1", "url": "https://omabrowser.org/oma/group/A0AAA9SWR1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S454-1", "protein_name": "Sulfotransferase", "gene_name": "LOC100522551", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWLRRISSTAVTALLLAQTGLLLFLVSRPRLPSQAGGEERVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWSALSQGSAAALHMAVRDLVRSVFLCDMDVFDAYLPWRRNLSDLFQWAESRALCSPPACSAFPRGAISSEAVCKPLCARRPFSLAQEACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGKWVEADPDLRVVREVCRSHVRIAEAAKHKPPPSLQGRYRLVRFEDLARAPLPEIRALYAFTGLSLTPQLEAWIHNITHGVGPGARREAFKTTSRNALNVSQAWRHALPFAKIRRVQELCSGALQLLGYRPVFSEEEQRDLSLDLVLPLGPSSFSWASSTAKHPGP", "length": 395 }, "evidence": [ { "id": "A0AAA9SWR1", "url": "https://omabrowser.org/oma/group/A0AAA9SWR1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9QUP4-1", "protein_name": "Carbohydrate sulfotransferase 5", "gene_name": "Chst5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLPRFSSTVMLSLLMVQTGILVFLVSRQVPSSPAGLGERVHVLVLSSWRSGSSFVGQLFSQHPDVFYLMEPAWHVWDTLSQGSAPALHMAVRDLIRSVFLCDMDVFDAYLPWRRNISDLFQWAVSRALCSPPVCEAFARGNISSEEVCKPLCATRPFGLAQEACSSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPRLRVVNEVCRSHVRIAEAALHKPPPFLQDRYRLVRYEDLARDPLTVIRELYAFTGLGLTPQLQTWIHNITHGSGPGARREAFKTTSRDALSVSQAWRHTLPFAKIRRVQELCGGALQLLGYRSVHSELEQRDLSLDLLLPRGMDSFKWASSTEKQPES", "length": 395 }, "evidence": [ { "id": "A0AAA9SWR1", "url": "https://omabrowser.org/oma/group/A0AAA9SWR1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "N-acetylglucosamine 6-O-sulfotransferase activity", "id": "GO:0001517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWR1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF08366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Z3", "url": "https://www.uniprot.org/uniprotkb/F1N3Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N3Z3-1", "url": "https://www.uniprot.org/uniprotkb/F1N3Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPGAPNHASVGRAVCYENQPPVTQSEVLLRAGSQDKPTPMRVFLLCLQQDSVESIASVPPPEAPGRPRFLKLLRREPACLGGPHNKMRRFLRPGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVEFMGLHRENNTVVQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEDETFTLRGPPGAAPSATQITVVLPHSSHQLLYLGTESGNVFAVRLPAFRTLEDRAISSDAVLQWLPEEARQRRAFEIVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLSHFLSSQQLENVFWQRDSRLIVSCHSDGSYCQWRLTSNSPKPEPLRSCVPYGPFPCKAITKIFWLTTKQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLIEVDPAAAFDDPYALVVLAEEELVVIDLQTAGWPPVQPPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQSTHFSTMEWPIDGGTSLAPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTEPNESLSAQGEEEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEEAEHAVGQVEADLLRDQEGYRWKGHERLCARPGPVHFEPGFQPFVLVQCQPPAVVTSLVLHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRIRRSRASSRKRRPTGPPGEVQEGSSRAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFALRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSARLKLKLTALEGSRVRRVSAARFGSCRAEDYGEHHLAVLTNLGDVQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAESKKRSRPRNGSGPEKSLGRARNSGSQSDGEERRSGPVMEHALLNDERVLKEIQSTLEGDRGSCGDWRSQRVAVGYSLSNGGAE", "length": 1109, "header": "tr|A0AAA9SWS7-1|A0AAA9SWS7_BOVIN Isoform 1 of LLGL scribble cell polarity complex component 2 OS=Bos taurus OX=9913 GN=LLGL2 PE=3 SV=1 CANONICAL=A0AAA9SWS7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7/entry#A0AAA9SWS7-1", "sequence": { "sequence": "MSPGAPNHASVGRAVCYENQPPVTQSEVLLRAGSQDKPTPMRVFLLCLQQDSVESIASVPPPEAPGRPRFLKLLRREPACLGGPHNKMRRFLRPGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVEFMGLHRENNTVVQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEDETFTLRGPPGAAPSATQITVVLPHSSHQLLYLGTESGNVFAVRLPAFRTLEDRAISSDAVLQWLPEEARQRRAFEIVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLSHFLSSQQLENVFWQRDSRLIVSCHSDGSYCQWRLTSNSPKPEPLRSCVPYGPFPCKAITKIFWLTTKQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLIEVDPAAAFDDPYALVVLAEEELVVIDLQTAGWPPVQPPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQSTHFSTMEWPIDGGTSLAPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTEPNESLSAQGEEEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEEAEHAVGQVEADLLRDQEGYRWKGHERLCARPGPVHFEPGFQPFVLVQCQPPAVVTSLVLHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRIRRSRASSRKRRPTGPPGEVQEGSSRAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFALRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSARLKLKLTALEGSRVRRVSAARFGSCRAEDYGEHHLAVLTNLGDVQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAESKKRSRPRNGSGPEKSLGRARNSGSQSDGEERRSGPVMEHALLNDERVLKEIQSTLEGDRGSCGDWRSQRVAVGYSLSNGGAE", "length": 1109, "header": "tr|A0AAA9SWS7-1|A0AAA9SWS7_BOVIN Isoform 1 of LLGL scribble cell polarity complex component 2 OS=Bos taurus OX=9913 GN=LLGL2 PE=3 SV=1 CANONICAL=A0AAA9SWS7-1" }, "locus": { "chromosome": "19", "start_pos": 56014161, "end_pos": 55985157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111446.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111446.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090925.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090925.1" } ] } }, { "isoform_ac": "A0AAA9TGN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7/entry#A0AAA9TGN1-1", "sequence": { "sequence": "MVEESSQWQTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVEFMGLHRENNTVVQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEDETFTLRGPPGAAPSATQITVVLPHSSHQLLYLGTESGNVFAVRLPAFRTLEDRAISSDAVLQWLPEEARQRRAFEIVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLSHFLSSQQLENVFWQRDSRLIVSCHSDGSYCQWRLTSNSPKPEPLRSCVPYGPFPCKAITKIFWLTTKQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLIEVDPAAAFDDPYALVVLAEEELVVIDLQTAGWPPVQPPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQSTHFSTMEWPIDGGTSLAPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTEPNESLSAQGEEEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEEAEHAVGQVEADLLRDQEGYRWKGHERLCARPGPVHFEPGFQPFVLVQCQPPAVVTSLVLHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRIRRSRASSRKRRPTGPPGEVQEGSSRAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFALRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSARLKLKLTALEGSRVRRVSAARFGSCRAEDYGEHHLAVLTNLGDVQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAESKKRSRPRNGSGPEKSLGRARNSGSQSDGEERRSGPVMEHALLNDERVLKEIQSTLEGDRGSCGDWRSQRVAVGYSLSNGGAE", "length": 1006, "header": "tr|A0AAA9TGN1-1|A0AAA9TGN1_BOVIN Computationally mapped isoform of LLGL scribble cell polarity complex component 2 OS=Bos taurus OX=9913 GN=LLGL2 PE=3 SV=1 CANONICAL=A0AAA9SWS7-1" }, "locus": { "chromosome": "19", "start_pos": 55998209, "end_pos": 55985157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117937.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117937.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096026.1" } ] } }, { "isoform_ac": "F1N3Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7/entry#F1N3Z3-1", "sequence": { "sequence": "MRRFLRPGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYPFWKGWGPWPCYGAPGVEFMGLHRENNTVVQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEDETFTLRGPPGAAPSATQITVVLPHSSHQLLYLGTESGNVFAVRLPAFRTLEDRAISSDAVLQWLPEEARQRRAFEIVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLSHFLSSQQLENVFWQRDSRLIVSCHSDGSYCQWRLTSNSPKPEPLRSCVPYGPFPCKAITKIFWLTTKQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLIEVDPAAAFDDPYALVVLAEEELVVIDLQTAGWPPVQPPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQSTHFSTMEWPIDGGTSLAPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTEPNESLSAQGEEEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEEAEHAVGQVEADLLRDQEGYRWKGHERLCARPGPVHFEPGFQPFVLVQCQPPAVVTSLVLHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRIRRSRASSRKRRPTGPPGEVQEGSSRAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFALRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSARLKLKLTALEGSRVRRVSAARFGSCRAEDYGEHHLAVLTNLGDVQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAESKKRSRPRNGSGPEKSLGRARNSGSQSDGEERRSGPVMEHALLNDERVLKEIQSTLEGDRGSCGDWRSQRVAVGYSLSNGGAE", "length": 1034, "header": "tr|F1N3Z3-1|F1N3Z3_BOVIN Computationally mapped isoform of LLGL scribble cell polarity complex component 2 OS=Bos taurus OX=9913 GN=LLGL2 PE=3 SV=4 CANONICAL=A0AAA9SWS7-1" }, "locus": { "chromosome": "19", "start_pos": 56009553, "end_pos": 55985157, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026738.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026738.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026738.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026738.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of establishment or maintenance of cell polarity", "id": "GO:0032878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032878", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" }, { "name": "L-leucine transport", "id": "GO:0015820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015820", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1035, "end_pos": 1037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 563, "end_pos": 565, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWS7" }, { "id": "PF08366", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08366" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lethal giant larvae homologue 2", "eco_id": "ECO_0000259", "start_pos": 360, "end_pos": 459, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1035, "end_pos": 1037 }, { "start_pos": 111, "end_pos": 113 }, { "start_pos": 160, "end_pos": 162 }, { "start_pos": 563, "end_pos": 565 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWT3-1", "uniprot_ac": "A0AAA9SWT3", "uniprot_id": "A0AAA9SWT3_BOVIN", "mass": { "chemical_mass": 23192.0, "monoisotopic_mass": 23192.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Phosphatidylcholine transfer protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SWT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3/entry#names_and_taxonomy" } ] }, { "name": "START domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SWT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3/entry#names_and_taxonomy" } ] }, { "name": "StAR-related lipid transfer protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SWT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3", "locus": {} } ], "crossref": [ { "id": "A0AAA9SWT3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19308", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19308", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19308:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19308:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASARSFSEEQFQEACAELQSPWLLGWNWQVESRGLTIYRKLHRPTGLYEYKFIGTLRALPDLLVDIGMDLGYIRRQIPQVTEAYETECDGETVTYMKMEFPFFVSSRDCVYVKQRRDLDFRGRKIQVVLAKGTSLPQFPERPGFIRVRQCQVKLAVESDGHNRSKVLIYWFINPGGWIPSWLINLLVKVRPPEAGGKRA", "length": 200, "header": "tr|A0AAA9SWT3-1|A0AAA9SWT3_BOVIN Isoform 1 of Phosphatidylcholine transfer protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SWT3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3/entry#A0AAA9SWT3-1", "sequence": { "sequence": "MASARSFSEEQFQEACAELQSPWLLGWNWQVESRGLTIYRKLHRPTGLYEYKFIGTLRALPDLLVDIGMDLGYIRRQIPQVTEAYETECDGETVTYMKMEFPFFVSSRDCVYVKQRRDLDFRGRKIQVVLAKGTSLPQFPERPGFIRVRQCQVKLAVESDGHNRSKVLIYWFINPGGWIPSWLINLLVKVRPPEAGGKRA", "length": 200, "header": "tr|A0AAA9SWT3-1|A0AAA9SWT3_BOVIN Isoform 1 of Phosphatidylcholine transfer protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9SWT3-1" }, "locus": { "chromosome": "19", "start_pos": 6437586, "end_pos": 6396123, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113285.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113285.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087701.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087701.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWT3" }, { "id": "PS50848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "START", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 185, "start_aa": "Gly", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWU6-1", "uniprot_ac": "A0AAA9SWU6", "uniprot_id": "A0AAA9SWU6_BOVIN", "mass": { "chemical_mass": 47367.0, "monoisotopic_mass": 47367.0 }, "refseq": { "ac": "XP_059746292", "name": "geranylgeranyl transferase type-1 subunit beta isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746292" }, "gene_names": [ { "name": "PGGT1B", "type": "recommended", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "name": "PGGT1B", "type": "synonym", "evidence": [ { "id": "XP_059746292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746292" } ] } ], "protein_names": [ { "name": "Geranylgeranyl transferase type-1 subunit beta", "type": "recommended", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#names_and_taxonomy" } ] }, { "name": "2.5.1.59", "type": "synonym", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#names_and_taxonomy" } ] }, { "name": "Geranylgeranyl transferase type I subunit beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#names_and_taxonomy" } ] }, { "name": "Type I protein geranyl-geranyltransferase subunit beta", "type": "synonym", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#names_and_taxonomy" } ] }, { "name": "geranylgeranyl transferase type-1 subunit beta isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059746292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746292" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PGGT1B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6", "locus": { "chromosome": "10", "start_pos": 4046135, "end_pos": 4104904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001895", "url": "https://www.ensembl.org/id/ENSBTAG00000001895" } ] } } ], "crossref": [ { "id": "A0AAA9SWU6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWU6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd02895", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02895", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509322", "url": "https://www.ncbi.nlm.nih.gov/gene/509322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11774:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11774:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00432", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059746292", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746292", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21240", "url": "https://www.rhea-db.org/rhea/21240", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIU2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YIU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YIU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRSVPAAAAKSLYSCLTLCDPIDGSPPDSSVPGILQARILEWVAISFSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 424, "header": "tr|A0AAA9SWU6-1|A0AAA9SWU6_BOVIN Isoform 1 of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=3 SV=1 CANONICAL=A0AAA9SWU6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#A0AAA9SWU6-1", "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRSVPAAAAKSLYSCLTLCDPIDGSPPDSSVPGILQARILEWVAISFSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 424, "header": "tr|A0AAA9SWU6-1|A0AAA9SWU6_BOVIN Isoform 1 of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=3 SV=1 CANONICAL=A0AAA9SWU6-1" }, "locus": { "chromosome": "10", "start_pos": 4104884, "end_pos": 4051277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107053.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107053.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087717.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087717.1" } ] } }, { "isoform_ac": "A0AAA9TTB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#A0AAA9TTB5-1", "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 300, "header": "tr|A0AAA9TTB5-1|A0AAA9TTB5_BOVIN Computationally mapped isoform of Protein geranylgeranyltransferase type I subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=3 SV=1 CANONICAL=A0AAA9SWU6-1" }, "locus": { "chromosome": "10", "start_pos": 4104884, "end_pos": 4051277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098044.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098044.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101873.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101873.1" } ] } }, { "isoform_ac": "A0AAA9TUZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#A0AAA9TUZ7-1", "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNGLEEHTAWQSLWCW", "length": 359, "header": "tr|A0AAA9TUZ7-1|A0AAA9TUZ7_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=3 SV=1 CANONICAL=A0AAA9SWU6-1" }, "locus": { "chromosome": "10", "start_pos": 4104884, "end_pos": 4046256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094780.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094780.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101204.1" } ] } }, { "isoform_ac": "A0AAF6YIU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6/entry#A0AAF6YIU2-1", "sequence": { "sequence": "MAATEDERPTGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGRYSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAINYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSENVHIST", "length": 379, "header": "tr|A0AAF6YIU2-1|A0AAF6YIU2_BOVIN Computationally mapped isoform of Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus OX=9913 GN=PGGT1B PE=3 SV=1 CANONICAL=A0AAA9SWU6-1" }, "locus": { "chromosome": "10", "start_pos": 4104884, "end_pos": 4051277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002466.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002466.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002466.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002466.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "CAAX-protein geranylgeranyltransferase activity", "id": "GO:0004662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004662", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "pmid": "" }, { "name": "protein prenyltransferase activity", "id": "GO:0008318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008318", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "CAAX-protein geranylgeranyltransferase complex", "id": "GO:0005953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005953", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "CAAX-box protein maturation", "id": "GO:0080120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080120", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21240", "name": "", "equation": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5EA80-1", "A0AAF6Z5M1-1", "Q5EAD5-1", "P29702-1", "Q5E9B3-1", "A0AAA9SWU6-1", "A0AAA9S4G1-1" ], "evidence": [ { "id": "21240", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21240" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9S4G1", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9S4G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G1" } ] } ] }, { "uniprot_ac": "A0AAA9SWU6", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" } ] } ] }, { "uniprot_ac": "A0AAF6Z5M1", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "A0AAF6Z5M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z5M1" } ] } ] }, { "uniprot_ac": "P29702", "gene_name": "FNTA", "activity": [ { "ec_number": "2.5.1.58", "activity": "L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.58", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "P29702", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P29702" } ] } ] }, { "uniprot_ac": "Q5E9B3", "gene_name": "RABGGTB", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5E9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B3" } ] } ] }, { "uniprot_ac": "Q5EA80", "gene_name": "RABGGTA", "activity": [ { "ec_number": "2.5.1.60", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] }, { "ec_number": "2.5.1.60", "activity": "", "evidence": [ { "id": "Q5EA80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA80" } ] } ] }, { "uniprot_ac": "Q5EAD5", "gene_name": "PGGT1B", "activity": [ { "ec_number": "2.5.1.59", "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] }, { "ec_number": "2.5.1.59", "activity": "", "evidence": [ { "id": "Q5EAD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWU6" }, { "id": "PF00432", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00432" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Prenyltransferase alpha-alpha toroid", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 48, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.5.1.59", "ec_name": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate.", "evidence": [ { "id": "2.5.1.59", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59" }, { "id": "2.5.1.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.5.1.59" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 }, { "start_pos": 392, "end_pos": 394 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWV7-1", "uniprot_ac": "A0AAA9SWV7", "uniprot_id": "A0AAA9SWV7_BOVIN", "mass": { "chemical_mass": 108592.0, "monoisotopic_mass": 108592.0 }, "refseq": {}, "gene_names": [ { "name": "LOC515089", "type": "recommended", "evidence": [ { "id": "A0AAA9SWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7" } ] } ], "protein_names": [ { "name": "Zinc finger protein 160-like", "type": "recommended", "evidence": [ { "id": "A0AAA9SWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC515089", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7", "locus": {} } ], "crossref": [ { "id": "A0AAA9SWV7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SWV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSQERLTSEDVAIEFTQEEWEFLDPAQRALYRDVMLETYRNLLSVDISPTHVIKHLQLKANSEKLETFQTSMLGRPESCEIKHFHLWESQENMRDFECQGRDDKRNYKGTPVSLNGNMPDGRDLHDRKDAGIKPFGNRLGFNFQDKLQIFQTGGIISEYDEAKRSVNNSFSFSPLQRIPPCVQPSVSNIYGNDFINPSVITQELKAHKEKPYKCDECGKTFRVKSILLSHQTVHTGEKPYKCDECGKAFTDSSHLRRHKKIHTGKKLFKCDICDKVFSRNEHLAGHQRVHSGEKPYKCDECGKAFTHSSHLRRHKKIHTGKKLFKCDICDKVFSRNEHLAVHQRVHTGEKPYKCDECGKHFSQPSQFTSHKRFHTREKPYKCDECGKQFSQPSQFISHKRFHTGEKPYKCDECGKAFHVKSILFRHQTIHTGEKPYKCDECGKAFTDISNLGRHQKIHTEKKLFKCDICDKVFSRSEHLAGHQRVHTGEKPYKCDECGKHFSRASQFISHQRVHSGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFRVKSTLLTHQTVHTGEKPYKCDECGKAFSDSSSRRRHQKIHTGKKLFKCDICDKVFSRNEHLAGHQRVHTGEQPYKCDECGKAFHEKSILLRHQTVHIGEKPYKCNECDKAFRVKSILLRHQTVHIGEKPYKCDECGKAFRVKSPLLTHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGGKPYKCDECGKAFRVNSILLRHQTVHTGEKPYKCDECGKAFRVKSTLLTHQTVHTGEKPYKCDECGNVFSQKAHLQLHWRIHTGERPFRCNECGKFFSQNSHLKRHWRIHIEKPFKYFECGKSFTQVSALTKHQKIHT", "length": 936, "header": "tr|A0AAA9SWV7-1|A0AAA9SWV7_BOVIN 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"MALSQERLTSEDVAIEFTQEEWEFLDPAQRALYRDVMLETYRNLLSVDISPTHVIKHLQLKANSEKLETFQTSMLGRPESCEIKHFHLWESQENMRDFECQGRDDKRNYKGTPVSLNGNMPDGRDLHDRKDAGIKPFGNRLGFNFQDKLQIFQTGGIISEYDEAKRSVNNSFSFSPLQRIPPCVQPSVSNIYGNDFINPSVITQELKAHKEKPYKCDECGKTFRVKSILLSHQTVHTGEKPYKCDECGKAFTDSSHLRRHKKIHTGKKLFKCDICDKVFSRNEHLAGHQRVHSGEKPYKCDECGKAFTHSSHLRRHKKIHTGKKLFKCDICDKVFSRNEHLAVHQRVHTGEKPYKCDECGKHFSQPSQFTSHKRFHTREKPYKCDECGKQFSQPSQFISHKRFHTGEKPYKCDECGKAFHVKSILFRHQTIHTGEKPYKCDECGKAFTDISNLGRHQKIHTEKKLFKCDICDKVFSRSEHLAGHQRVHTGEKPYKCDECGKHFSRASQFISHQRVHSGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFRVKSTLLTHQTVHTGEKPYKCDECGKAFSDSSSRRRHQKIHTGKKLFKCDICDKVFSRNEHLAGHQRVHTGEQPYKCDECGKAFHEKSILLRHQTVHIGEKPYKCNECDKAFRVKSILLRHQTVHIGEKPYKCDECGKAFRVKSPLLTHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGEKPYKCDECGKAFHEKSILLRHQTVHTGGKPYKCDECGKAFRVNSILLRHQTVHTGEKPYKCDECGKAFRVKSTLLTHQTVHTGEKPYKCDECGNVFSQKAHLQLHWRIHTGERPFRCNECGKFFSQNSHLKRHWRIHIEKPFKYFECGKSFTQVSALTKHQKIHT", "length": 936, "header": "tr|A0AAA9SWV7-1|A0AAA9SWV7_BOVIN 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"MATPILWPRPLRAQRRLWLRPSAGLSGGCALRPLPPRPRAPSQPGRALSFRGRWAARLWGRGPEEAVEPMGRGGGGGGGGGGGGGGGSGSGWVGPRRAAAAEVEAEGGGGGGGGEGGGGGGGGGKMAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSIFGLIFYILQLLLGLTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICVITYVLNFILLIINYKRLVYLNEAWKRQLQPKQD", "length": 301, "header": "tr|A0ABI0NTU1-1|A0ABI0NTU1_BOVIN Computationally mapped isoform of vitamin-K-epoxide reductase (warfarin-sensitive) OS=Bos taurus OX=9913 GN=VKORC1L1 PE=3 SV=1 CANONICAL=A0AAA9SWV9-1" }, "locus": { "chromosome": "25", "start_pos": 27901122, "end_pos": 27844906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148612.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148612.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106925.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106925.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], 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"https://omabrowser.org/oma/group/ISCDCQR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3X6Q8", "url": "https://www.orthodb.org/?gene=G3X6Q8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46943", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46943", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46943:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46943:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00354", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00354", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26206", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26206", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6Q8", "url": "https://www.uniprot.org/uniprotkb/G3X6Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6Q8-1", "url": "https://www.uniprot.org/uniprotkb/G3X6Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPRFVVKTPKPRMGRPVSAENSDDYELMYVNLDNEIDNGLHPTEDPTPCDCSRENSEWDKLFTMLENSQMREGMLLQATDVMLRGELQKLQAELGRLEGSLQKLCGPEAPSETRLARALDDLLQASRDAGRRLARLEDAGALRPQEEAGRALGAVLEELRRTRADLRAVQGWAASRWLPAGCETAILFPMRSKKIFASVHPVTPMKLETFSACIWVKATEVLNKTVLFSYGTKRNPYEIQLYLSYRSIMLVVGGEENRLVADAVISLGTWTHLCSTWDSKKGHMALWVNGDSVATAVDMATGHVVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDGVLSNEEIREAGGAESCHIRGNVVGWGVTEIQPHGGAQYVY", "length": 385, "header": "tr|A0AAA9SX10-1|A0AAA9SX10_BOVIN Isoform 1 of Pentraxin-related protein PTX3 OS=Bos taurus OX=9913 GN=PTX3 PE=4 SV=1 CANONICAL=A0AAA9SX10-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SX10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10/entry#A0AAA9SX10-1", "sequence": { "sequence": "MDPRFVVKTPKPRMGRPVSAENSDDYELMYVNLDNEIDNGLHPTEDPTPCDCSRENSEWDKLFTMLENSQMREGMLLQATDVMLRGELQKLQAELGRLEGSLQKLCGPEAPSETRLARALDDLLQASRDAGRRLARLEDAGALRPQEEAGRALGAVLEELRRTRADLRAVQGWAASRWLPAGCETAILFPMRSKKIFASVHPVTPMKLETFSACIWVKATEVLNKTVLFSYGTKRNPYEIQLYLSYRSIMLVVGGEENRLVADAVISLGTWTHLCSTWDSKKGHMALWVNGDSVATAVDMATGHVVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDGVLSNEEIREAGGAESCHIRGNVVGWGVTEIQPHGGAQYVY", "length": 385, "header": "tr|A0AAA9SX10-1|A0AAA9SX10_BOVIN Isoform 1 of Pentraxin-related protein PTX3 OS=Bos taurus OX=9913 GN=PTX3 PE=4 SV=1 CANONICAL=A0AAA9SX10-1" }, "locus": { "chromosome": "1", "start_pos": 110231062, "end_pos": 110158803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089861.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089861.1" } ] } }, { "isoform_ac": "G3X6Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10/entry#G3X6Q8-1", "sequence": { "sequence": "MHISVILFCALWSAVSAENSDDYELMYVNLDNEIDNGLHPTEDPTPCDCSRENSEWDKLFTMLENSQMREGMLLQATDVMLRGELQKLQAELGRLEGSLQKLCGPEAPSETRLARALDDLLQASRDAGRRLARLEDAGALRPQEEAGRALGAVLEELRRTRADLRAVQGWAASRWLPAGCETAILFPMRSKKIFASVHPVTPMKLETFSACIWVKATEVLNKTVLFSYGTKRNPYEIQLYLSYRSIMLVVGGEENRLVADAVISLGTWTHLCSTWDSKKGHMALWVNGDSVATAVDMATGHVVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDGVLSNEEIREAGGAESCHIRGNVVGWGVTEIQPHGGAQYVY", "length": 382, "header": "tr|G3X6Q8-1|G3X6Q8_BOVIN Computationally mapped isoform of Pentraxin-related protein PTX3 OS=Bos taurus OX=9913 GN=PTX3 PE=4 SV=1 CANONICAL=A0AAA9SX10-1" }, "locus": { "chromosome": "1", "start_pos": 110164171, "end_pos": 110158803, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011863.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011863.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011863.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011863.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 48, "start_aa": "Thr", "end_pos": 48, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LXB5-1", "protein_name": "Pentraxin-related protein PTX3", "gene_name": "Ptx3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLAETSYDYELMHVNLDNEIDNGLHPTEDPTPCDCRQEHSEWDKLFIMLENSQMREAMLLQATDDVLRGELQRLRAELGRLAGGMARPCSASGPADARLAQALEPLLQESRDANRRLARLEDAEARRHEATVPSLGAVLEELQRTRADLSAMQSWVARHWLPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSACIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQSLVFVVGGKENKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTLEMAKSHPVPEGGLLQIGQEKNGCCVGGGFDETLAFSGRITGFNIWDRVLSKEEIRASGGAESCHIRGNIVGWGVTEIQAHGGAQYVS", "length": 367 }, "evidence": [ { "id": "A0AAA9SX10", "url": "https://omabrowser.org/oma/group/A0AAA9SX10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A3KPN2-1", "protein_name": "Pentraxin-related protein PTX3", "gene_name": "ptx3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MASKSMWTFLQTMCLVASLSMAVSDNYDDDIEVGFGHNYFNEIPDEDQLEDETPTPSPEPCKNTAFTKWDKLFTMLENSQMKENMLLQYADDIIKVELQNLRGEMIQFVAQYGGSCASAVESSVRRAGTQTESCLQNALDRAREVSADRYEQHDAVLQQLLAVSVNQAAQLDRLEKGCLKSGAFKNIQTRHLMQDVTEIENGGKLEKSLETISSELQSIREQLSLYTRSAFADKLPSGCDTGLLFPTRSSKAHAEVSPHGLLRTNAVTICLWVKPTQVFNKTILFSYSTTGNAYELQLVLSGQSASFTVDGESHLVEASGAVQEGQWGHLCASWSSQQGLASLWVNGQQAASSPGVAEGHELRSKGSILLGQEYGRHYKHLSTPDTFDAELAFTGKMTGVNMWDRVLDPKEISQQARLYGTACGIRGNVVAWGVSDIQPKEGVKLLY", "length": 447 }, "evidence": [ { "id": "A0AAA9SX10", "url": "https://omabrowser.org/oma/group/A0AAA9SX10/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H217-1", "protein_name": "Pentraxin-related protein PTX3", "gene_name": "Ptx3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHLPAILLCAFWCAVLAETSDDYELMYVHLDNEIDNGLHPTEDPTPCDCRPEHSEWDKLFIMLENSQMREGMLLQATDDVLRGELQRLRAELGRLAGGMARPCAAGGPTDARLARVLEPLLQESRDVSRRLARLEDAEARRPEATVPGLGAVLEELQRTRADLSAVQSWLARRWLPAGCETAILFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQSLVFVVGGKENKLTADIVVSLGRWTHLCGTWSSEQGSMSLWVNGERVATTVEMAMLHSVPEGGILQIGQEKNGCCVGGGFDETLAFSGRITGFNIWDRVLSEEEIRESGGVESCHIRGNIVGWGVTEIQPHGGAQYVS", "length": 381 }, "evidence": [ { "id": "A0AAA9SX10", "url": "https://omabrowser.org/oma/group/A0AAA9SX10/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P26022-1", "protein_name": "Pentraxin-related protein PTX3", "gene_name": "PTX3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS", "length": 381 }, "evidence": [ { "id": "A0AAA9SX10", "url": "https://omabrowser.org/oma/group/A0AAA9SX10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P48759-1", "protein_name": "Pentraxin-related protein PTX3", "gene_name": "Ptx3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHLPAILLCALWSAVVAETSDDYELMYVNLDNEIDNGLHPTEDPTPCDCRQEHSEWDKLFIMLENSQMREGMLLQATDDVLRGELQRLRAELGRLAGGMARPCAAGGPADARLVRALEPLLQESRDASLRLARLEDAEARRPEATVPGLGAVLEELRRTRADLSAVQSWVARHWLPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQSLVLVVGGKENKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTVEMAKSHSVPEGGLLQIGQEKNGCCVGGGFDESLAFSGRITGFNIWDRVLSEEEIRASGGVESCHIRGNVVGWGVTEIQAHGGAQYVS", "length": 381 }, "evidence": [ { "id": "A0AAA9SX10", "url": "https://omabrowser.org/oma/group/A0AAA9SX10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "(1->3)-beta-D-glucan binding", "id": "GO:0001872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "complement component C1q complex binding", "id": "GO:0001849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001849", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "virion binding", "id": "GO:0046790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046790", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation by host of viral glycoprotein metabolic process", "id": "GO:0044871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "host-mediated suppression of symbiont invasion", "id": "GO:0046597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046597", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" }, { "name": "host-mediated suppression of viral proces", "id": "GO:0044793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SX10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX10" }, { "id": "PS51828", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51828" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pentraxin (PTX)", "eco_id": "ECO_0000259", "start_pos": 183, "end_pos": 385, "start_aa": "Cys", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 48 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 224, "end_pos": 226 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"domain_list": [ { "evidence": [ { "id": "A0AAA9SX35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX35" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 6, "end_pos": 8 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SX42-1", "uniprot_ac": "A0AAA9SX42", "uniprot_id": "A0AAA9SX42_BOVIN", "mass": { "chemical_mass": 148562.0, "monoisotopic_mass": 148562.0 }, "refseq": {}, "gene_names": [ { "name": "TDRD12", "type": "recommended", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ], "protein_names": [ { "name": "Putative ATP-dependent RNA helicase TDRD12", "type": "recommended", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#names_and_taxonomy" } ] }, { "name": "ES cell-associated transcript 8 protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#names_and_taxonomy" } ] }, { "name": "Tudor domain-containing protein 12", "type": "synonym", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THI3#function" }, { "database": "UniProtKB", "id": "ARBA00055914", "url": "https://www.uniprot.org/uniprotkb/ARBA00055914#function" }, { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TDRD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42", "locus": { "chromosome": "18", "start_pos": 43263184, "end_pos": 43188296, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019266", "url": "https://www.ensembl.org/id/ENSBTAG00000019266" } ] } } ], "crossref": [ { "id": "cd20434", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20434", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20435", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20435", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22655", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22655", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22655:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22655:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THI3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKC5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQVLVLKIEDPGCFWVVIKGCSPFLDHEVDYQKLNSAMNDFYNSLCQDIEIKPLKLEEGQVCVVYCQELKCWCRAVIKSIVSSADHYLAECFLVDFARYIPVKSRNIRVAIETFMQLPYRAKKFRLYCTKPVTLHINFCEDSAEIVRAKKWDSAAIQYFQNILKATTQVEAKLCAVEEDTFEVYLYVTLKNEKVCVNDDLVAKNFACYVSPMENKNFDSLEKPRLNIKSASFSSKLNPALTLWPMFLQGKDSQRMETKSLKHPWPQGAGDFRPTSRLLEKTVKCNMDSLKGSPKKESEKKQQYISLKDVNKCVESSVCWPTKRGITIYANPDTPAASASCQKSSEKPLRSAEKKEYNEKNGCVKLLQFLNPDPLRADGISDLQQLQKLKSGSRQPMAVLRNKIEPCLSIETAPLSTDLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCGNDPSLYLPPVLTILQTGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSASCRPLHPVLLTIGLHKDEAKNMKLPRGCNVVVTTPHSLLRLLQYQSLLFLRLCHLLLDEVEVLLSEANEQMFAILDNFKKHMEVEERESAPHQIVAVGVHWNRHIEHLIKEFMNDPYIVITAMEEAALYGCVQQVVHLCLECEKTSTLLQTLDFTPSQAQKTLIFTCSAAETETVCKVVESNSIFCLKMHKEMIFNLKSVSQQWKKKLSSGSHIVLALTDDCIPLLAITDATCIIHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSAEQGDKKTKSVLLLSERNACHAVGVLRYLERADAKIPSELYEFTAGVLEAKEDGKVRRPLCPYLKAFGFCKDRRICPDRHRVNPEVDIPRKLSSQTLPVLGYIKIIPFYVLNATNYFGRIVDKHEDLCATLNAEMKEYFEDSSNKATVEKIEKFGLYGLAEKSVFHSLRPLLFCRVQVLEMRQKEDTWALDHVLVKFIDEGRTGLVTRDQLLHLPESFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIIGKLHDAKVILALGDTVWIDPMVHITKLSNLKTSVIDYNVRAEILSMGMGIDNSEHVEQLKKLYKGAKMPSFEESLNQTLVPSSREDSACLPSTQQEDKGSERGTDTKTNSENQKHETLPKNTGGASINKTAEPPKSFHPQIKWFQKEDVVILKIKIRNVKDYKCKYFRDRVVFSAWVGEKFYLADLELQANIIKDDCKCIIKYDEPVITLVKEQRESWCGLLKQRNPNVAFDFDHWEDCDEDKEDSHFAKVVNSKNLSCNVAGLVETSDKSSDEDESESE", "length": 1308, "header": "tr|A0AAA9SX42-1|A0AAA9SX42_BOVIN Isoform 1 of Putative ATP-dependent RNA helicase TDRD12 OS=Bos taurus OX=9913 GN=TDRD12 PE=4 SV=1 CANONICAL=A0AAA9SX42-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SX42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#A0AAA9SX42-1", "sequence": { "sequence": "MLQVLVLKIEDPGCFWVVIKGCSPFLDHEVDYQKLNSAMNDFYNSLCQDIEIKPLKLEEGQVCVVYCQELKCWCRAVIKSIVSSADHYLAECFLVDFARYIPVKSRNIRVAIETFMQLPYRAKKFRLYCTKPVTLHINFCEDSAEIVRAKKWDSAAIQYFQNILKATTQVEAKLCAVEEDTFEVYLYVTLKNEKVCVNDDLVAKNFACYVSPMENKNFDSLEKPRLNIKSASFSSKLNPALTLWPMFLQGKDSQRMETKSLKHPWPQGAGDFRPTSRLLEKTVKCNMDSLKGSPKKESEKKQQYISLKDVNKCVESSVCWPTKRGITIYANPDTPAASASCQKSSEKPLRSAEKKEYNEKNGCVKLLQFLNPDPLRADGISDLQQLQKLKSGSRQPMAVLRNKIEPCLSIETAPLSTDLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCGNDPSLYLPPVLTILQTGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSASCRPLHPVLLTIGLHKDEAKNMKLPRGCNVVVTTPHSLLRLLQYQSLLFLRLCHLLLDEVEVLLSEANEQMFAILDNFKKHMEVEERESAPHQIVAVGVHWNRHIEHLIKEFMNDPYIVITAMEEAALYGCVQQVVHLCLECEKTSTLLQTLDFTPSQAQKTLIFTCSAAETETVCKVVESNSIFCLKMHKEMIFNLKSVSQQWKKKLSSGSHIVLALTDDCIPLLAITDATCIIHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSAEQGDKKTKSVLLLSERNACHAVGVLRYLERADAKIPSELYEFTAGVLEAKEDGKVRRPLCPYLKAFGFCKDRRICPDRHRVNPEVDIPRKLSSQTLPVLGYIKIIPFYVLNATNYFGRIVDKHEDLCATLNAEMKEYFEDSSNKATVEKIEKFGLYGLAEKSVFHSLRPLLFCRVQVLEMRQKEDTWALDHVLVKFIDEGRTGLVTRDQLLHLPESFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIIGKLHDAKVILALGDTVWIDPMVHITKLSNLKTSVIDYNVRAEILSMGMGIDNSEHVEQLKKLYKGAKMPSFEESLNQTLVPSSREDSACLPSTQQEDKGSERGTDTKTNSENQKHETLPKNTGGASINKTAEPPKSFHPQIKWFQKEDVVILKIKIRNVKDYKCKYFRDRVVFSAWVGEKFYLADLELQANIIKDDCKCIIKYDEPVITLVKEQRESWCGLLKQRNPNVAFDFDHWEDCDEDKEDSHFAKVVNSKNLSCNVAGLVETSDKSSDEDESESE", "length": 1308, "header": "tr|A0AAA9SX42-1|A0AAA9SX42_BOVIN Isoform 1 of Putative ATP-dependent RNA helicase TDRD12 OS=Bos taurus OX=9913 GN=TDRD12 PE=4 SV=1 CANONICAL=A0AAA9SX42-1" }, "locus": { "chromosome": "18", "start_pos": 43262180, "end_pos": 43188495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105411.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105411.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089903.1" } ] } }, { "isoform_ac": "A0AAA9THI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#A0AAA9THI3-1", "sequence": { "sequence": "MNDFYNSLCQDIEIKPLKLEEGQVCVVYCQELKCWCRAVIKSIVSSADHYLAECFLVDFARYIPVKSRNIRVAIETFMQLPYRAKKFRLYCTKPVTLHINFCEDSAEIVRAKKWDSAAIQYFQNILKATTQVEAKLCAVEEDTFEVYLYVTLKNEKVCVNDDLVAKNFACYVSPMENKNFDSLEKPRLNIKSASFSSKLNPALTLWPMFLQGKDSQRMETKSLKHPWPQGAGDFRPTSRLLEKTVKCNMDSLKGSPKKESEKKQQYISLKDVNKCVESSVCWPTKRGITIYANPDTPAASASCQKSSEKPLRSAEKKEYNEKNGCVKLLQFLNPDPLRADGISDLQQLQKLKSGSRQPMAVLRNKIEPCLSIETAPLSTDLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCGNDPSLYLPPVLTILQTGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSASCRPLHPVLLTIGLHKDEAKNMKLPRGCNVVVTTPHSLLRLLQYQSLLFLRLCHLLLDEVEVLLSEANEQMFAILDNFKKHMEVEERESAPHQIVAVGVHWNRHIEHLIKEFMNDPYIVITAMEEAALYGCVQQVVHLCLECEKTSTLLQTLDFTPSQAQKTLIFTCSAAETETVCKVVESNSIFCLKMHKEMIFNLKSVSQQWKKKLSSGSHIVLALTDDCIPLLAITDATCIIHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSAEQGDKKTKSVLLLSERNACHAVGVLRYLERADAKIPSELYEFTAGVLEAKEDGKVRRPLCPYLKAFGFCKDRRICPDRHRVNPEVDIPRKLSSQTLPVLGYIKIIPFYVLNATNYFGRIVDKHEDLCATLNAEMKEYFEDSSNKATVEKIEKFGLYGLAEKSVFHRVQVLEMRQKEDTWALDHVLVKFIDEGRTGLVTRDQLLHLPESFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIIGKLHDAKVILALGDTVWIDPMVHITKLSNLKTSVIDYNVRAEILSMGMGIDNSEHVEQLKKLYKGAKMPSFEESLNQTLVPSSREDSACLPSTQQEDKGSERGTDTKTNSENQKHETLPKNTGGASINKTAEPPKSFHPQIKWFQKEDVVILKIKIRNVKDYKCKYFRDRVVFSAWVGEKFYLADLELQANIIKDDCKCIIKYDEPVITLVKEQRESWCGLLKQRNPNVAFDFDHWEDCDEDKEDSHFAKVVNSKNLSCNVAGLVETSDKSSDEDESESE", "length": 1262, "header": "tr|A0AAA9THI3-1|A0AAA9THI3_BOVIN Computationally mapped isoform of Putative ATP-dependent RNA helicase TDRD12 OS=Bos taurus OX=9913 GN=TDRD12 PE=4 SV=1 CANONICAL=A0AAA9SX42-1" }, "locus": { "chromosome": "18", "start_pos": 43262180, "end_pos": 43201706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095673.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095673.1" } ] } }, { "isoform_ac": "A0AAA9TKC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42/entry#A0AAA9TKC5-1", "sequence": { "sequence": "MLQVLVLKIEDPGCFWVVIKGCSPFLDHEVDYQKLNSAMNDFYNSLCQDIEIKPLKLEEGQVCVVYCQELKCWCRAVIKSIVSSADHYLAECFLVDFARYIPVKSRKRAKKWDSAAIQYFQNILKATTQVEAKLCAVEEDTFEVYLYVTLKNEKVCVNDDLVAKNFACYVSPMENKNFDSLEKPRLNIKSASFSSKLNPALTLWPMFLQGKDSQRMETKSLKHPWPQGAGDFRPTSRLLEKTVKCNMDSLKGSPKKESEKKQQYISLKDVNKCVESSVCWPTKRGITIYANPDTPAASASCQKSSEKPLRSAEKKEYNEKNGCVKLLQFLNPDPLRADGISDLQQLQKLKSGSRQPMAVLRNKIEPCLSIETAPLSTDLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCGNDPSLYLPPVLTILQTGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSASCRPLHPVLLTIGLHKDEAKNMKLPRGCNVVVTTPHSLLRLLQYQSLLFLRLCHLLLDEVEVLLSEANEQMFAILDNFKKHMEVEERESAPHQIVAVGVHWNRHIEHLIKEFMNDPYIVITAMEEAALYGCVQQVVHLCLECEKTSTLLQTLDFTPSQAQKTLIFTCSAAETETVCKVVESNSIFCLKMHKEMIFNLKSVSQQWKKKLSSGSHIVLALTDDCIPLLAITDATCIIHFSFPSSPKVFGGRLYCMSDHFQSLTEQGSAEQGDKKTKSVLLLSERNACHAVGVLRYLERADAKIPSELYEFTAGVLEAKEDGKVRRPLCPYLKAFGFCKDRRICPDRHRVNPEVDIPRKLSSQTLPVLGYIKIIPFYVLNATNYFGRIVDKHEDLCATLNAEMKEYFEDSSNKATVEKIEKFGLYGLAEKSVFHRVQVLEMRQKEDTWALDHVLVKFIDEGRTGLVTRDQLLHLPESFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIIGKLHDAKVILALGDTVWIDPMVHITKLSNLKTSVIDYNVRAEILSMGMGIDNSEHVEQLKKLYKGAKMPSFEESLNQTLVPSSREDSACLPSTQQEDKGSERGTDTKTNSENQKHETLPKNTGGASINKTAEPPKSFHPQIKWFQKEDVVILKIKIRNVKDYKCKYFRDRVVFSAWVGEKFYLADLELQANIIKDDCKCIIKYDEPVITLVKEQRESWCGLLKQRNPNVAFDFDHWEDCDEDKEDSHFAKVVNSKNLSCNVAGLVETSDKSSDEDESESE", "length": 1260, "header": "tr|A0AAA9TKC5-1|A0AAA9TKC5_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=TDRD12 PE=4 SV=1 CANONICAL=A0AAA9SX42-1" }, "locus": { "chromosome": "18", "start_pos": 43262180, "end_pos": 43188495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094209.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094209.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096712.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1104, "end_pos": 1106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1156, "end_pos": 1158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1284, "end_pos": 1286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { 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"https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { 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a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": 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"uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP 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"database": "Ensembl Peptide", "id": "ENSBTAP00000087952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087952.1" } ] } }, { "isoform_ac": "A0AAA9TQI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3/entry#A0AAA9TQI6-1", "sequence": { "sequence": "MALSQQQMTVEDVAIKFTPEEWECLSPAQRTLYWDVMLETYRNLLSVDISPIHIIKKLQSKENTNSTDTLQTVILGRHESHGVQDFYLREIRGNTLEFECQWKDDERNYKGIFECNQVENVINNTHREKPYRCNDCDKTFTHVSHLTKHQVVHTGERPYKCDTCGKDFSQSSNLATHRRIHTGEKPYKCNECGKDFNRKSNLETHQRIHTGEKPYKCNVCGKAFSRNSKLLKHQRIHTRGQPYKCDACDKAFILRSSLINHQVVHTRGKSYPCNECGKMFIKRSHLRLHERIHTGEKPYKCTECGKGFRQWSDIRIHLRIHAGEKPFKCSKCGKSFTRSSHLTRHQIIHTGEKPYKCEVCDKFFSRNSHLAGHWRIHTREKPYKCNECGKAFSDRSSLTYHQVIHTGEKSYKCNECGKAFIKPSYLRVYTSLIINNP", "length": 437, "header": "tr|A0AAA9TQI6-1|A0AAA9TQI6_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9SXC3-1" }, "locus": { "chromosome": "2", "start_pos": 14414913, "end_pos": 14412779, "strand": "+", "evidence": [ { "database": 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CANONICAL=A0AAA9SXC3-1" }, "locus": { "chromosome": "2", "start_pos": 14414913, "end_pos": 14412939, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124609.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124609.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100479.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { 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"strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057521", "url": "https://www.ensembl.org/id/ENSBTAG00000057521" } ] } } ], "crossref": [ { "id": "A0AAA9SXF5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "617016", "url": "https://www.ncbi.nlm.nih.gov/gene/617016", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617016", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617016", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377162", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENHSTVTEFILGGLTNQPEFQLPLLFLFLGIYSVTMIGNLGMITVICLNPQLHTPMYYFLSNLSLVDLCYSSVITPKMLVNFVSEKNIISYAGCMAQLYFFLVFVIAECYMLTVMAYDRYVAICRPLLYNIIMSHRVCSLLVAGVYAIGFIGSTIETGLMLKLSYCDFLISHYFCDILPLMMLSCSSTYDTEMTVFVLAGFDIVVTSLTVLISYAFILSSILHISTTGGRAKAFSTCSSHLVAVGMFYGTTAFMYLKPSTASSLAQENMASVFYTTVIPMLNPLIYSLRNKEVKAAMQKTLRGKMF", "length": 308, "header": "tr|A0AAA9SXF5-1|A0AAA9SXF5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1D PE=3 SV=1 CANONICAL=A0AAA9SXF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5/entry#A0AAA9SXF5-1", "sequence": { "sequence": "MAENHSTVTEFILGGLTNQPEFQLPLLFLFLGIYSVTMIGNLGMITVICLNPQLHTPMYYFLSNLSLVDLCYSSVITPKMLVNFVSEKNIISYAGCMAQLYFFLVFVIAECYMLTVMAYDRYVAICRPLLYNIIMSHRVCSLLVAGVYAIGFIGSTIETGLMLKLSYCDFLISHYFCDILPLMMLSCSSTYDTEMTVFVLAGFDIVVTSLTVLISYAFILSSILHISTTGGRAKAFSTCSSHLVAVGMFYGTTAFMYLKPSTASSLAQENMASVFYTTVIPMLNPLIYSLRNKEVKAAMQKTLRGKMF", "length": 308, "header": "tr|A0AAA9SXF5-1|A0AAA9SXF5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1D PE=3 SV=1 CANONICAL=A0AAA9SXF5-1" }, "locus": { "chromosome": "29", "start_pos": 27950013, "end_pos": 27949090, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132455.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132455.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090033.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617016", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617016", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXF5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXG0-1", "uniprot_ac": "A0AAA9SXG0", "uniprot_id": "A0AAA9SXG0_BOVIN", "mass": { "chemical_mass": 85010.0, "monoisotopic_mass": 85010.0 }, "refseq": { "ac": "XP_059743622", "name": "YTH domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743622" }, "gene_names": [ { "name": "YTHDC1", "type": "recommended", "evidence": [ { "id": "A0AAA9SXG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ] }, { "name": "YTHDC1", "type": "synonym", "evidence": [ { "id": "XP_059743622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743622" } ] } ], "protein_names": [ { "name": "YTH domain-containing family protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SXG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0/entry#names_and_taxonomy" } ] }, { "name": "YTH domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059743622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743622" } ] } ], "function": [ { "annotation": "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0#function" }, { "database": "UniProtKB", "id": "RU369095", "url": "https://www.uniprot.org/uniprotkb/RU369095#function" }, { "database": "UniProtKB", "id": "A0AAA9T668", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T668#function" }, { "database": "UniProtKB", "id": "A0A3Q1MDY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDY9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YTHDC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0", "locus": { "chromosome": "6", "start_pos": 84139895, "end_pos": 84101801, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015572", "url": "https://www.ensembl.org/id/ENSBTAG00000015572" } ] } } ], "crossref": [ { "id": "A0AAA9SXG0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21134", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21134", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613858", "url": "https://www.ncbi.nlm.nih.gov/gene/613858", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDY9", "url": "https://www.orthodb.org/?gene=A0A3Q1MDY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12357:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12357:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059743622", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743622", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T668", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T668", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T668-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T668-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESADTKRQKPSVHSRQLISKPLSSSVNNNKRMVSTKGKSVTEYKNEEYQRSERNKRLEADRKIRLSSSASREPYKSQPDKTCLRKRDPERRVKSPTPDDSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSDSESVTFTDGSVRSGSGTDGSDEKKKERKRARGISPIIFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNVAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYAPEFHQRPGYLKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMTPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR", "length": 728, "header": "tr|A0AAA9SXG0-1|A0AAA9SXG0_BOVIN Isoform 1 of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDC1 PE=3 SV=2 CANONICAL=A0AAA9SXG0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0/entry#A0A3Q1MDY9-1", "sequence": { "sequence": "MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESADTKRQKPSVHSRQLISKPLSSSVNNNKRMVSTKGKSVTEYKNEEYQRSERNKRLEADRKIRLSSSASREPYKSQPDKTCLRKRDPERRVKSPTPDDSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSDSESVTFTDGSVRSGSGTDGSDEKKKERKRARGISPIIFDRSGSSASESYADQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNVAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYAPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMTPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR", "length": 718, "header": "tr|A0A3Q1MDY9-1|A0A3Q1MDY9_BOVIN Computationally mapped isoform of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDC1 PE=3 SV=2 CANONICAL=A0AAA9SXG0-1" }, "locus": { "chromosome": "6", "start_pos": 84139118, "end_pos": 84102019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075735.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075735.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067072.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067072.2" } ] } }, { "isoform_ac": "A0AAA9SXG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0/entry#A0AAA9SXG0-1", "sequence": { "sequence": "MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESADTKRQKPSVHSRQLISKPLSSSVNNNKRMVSTKGKSVTEYKNEEYQRSERNKRLEADRKIRLSSSASREPYKSQPDKTCLRKRDPERRVKSPTPDDSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSDSESVTFTDGSVRSGSGTDGSDEKKKERKRARGISPIIFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNVAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYAPEFHQRPGYLKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMTPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR", "length": 728, "header": "tr|A0AAA9SXG0-1|A0AAA9SXG0_BOVIN Isoform 1 of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDC1 PE=3 SV=2 CANONICAL=A0AAA9SXG0-1" }, "locus": { "chromosome": "6", "start_pos": 84139118, "end_pos": 84102019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098941.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098941.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091152.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091152.2" } ] } }, { "isoform_ac": "A0AAA9T668-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0/entry#A0AAA9T668-1", "sequence": { "sequence": "MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESADTKRQKPSVHSRQLISKPLSSSVNNNKRMVSTKGKSVTEYKNEEYQRSERNKRLEADRKIRLSSSASREPYKSQPDKTCLRKRDPERRVKSPTPDDSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEDVEEDEEVEEDAEEDEEEEEEYEQDERDQKEEGNDYDTRSEASDSDSESVTFTDGSVRSGSGTDGSDEKKKERKRARGISPIIFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNVAFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYAPEFHQRPGYLKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMTPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRGERGRYRR", "length": 713, "header": "tr|A0AAA9T668-1|A0AAA9T668_BOVIN Computationally mapped isoform of YTH domain-containing family protein OS=Bos taurus OX=9913 GN=YTHDC1 PE=3 SV=1 CANONICAL=A0AAA9SXG0-1" }, "locus": { "chromosome": "6", "start_pos": 84139118, "end_pos": 84102019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114974.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114974.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094257.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" }, { "name": "N6-methyladenosine-containing RNA reader activity", "id": "GO:1990247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990247", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "brown fat cell differentiation", "id": "GO:0050873", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050873", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" }, { "name": "post-transcriptional regulation of gene expression", "id": "GO:0010608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010608", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 587, "end_pos": 589, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG0" }, { "id": "PS50882", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50882" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YTH", "eco_id": "ECO_0000259", "start_pos": 356, "end_pos": 493, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 368, "end_pos": 370 }, { "start_pos": 587, "end_pos": 589 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXH1-1", "uniprot_ac": "A0AAA9SXH1", "uniprot_id": "A0AAA9SXH1_BOVIN", "mass": { "chemical_mass": 67585.0, "monoisotopic_mass": 67585.0 }, "refseq": {}, "gene_names": [ { "name": "N4BP3", "type": "recommended", "evidence": [ { "id": "A0AAA9SXH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ] } ], "protein_names": [ { "name": "NEDD4 binding protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9SXH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "N4BP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1", "locus": { "chromosome": "7", "start_pos": 39219191, "end_pos": 39210670, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006368", "url": "https://www.ensembl.org/id/ENSBTAG00000006368" } ] } } ], "crossref": [ { "id": "A0AAA9SXH1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXH1", "database": "AlphaFoldDB", "categories": [] }, { "id": "513032", "url": "https://www.ncbi.nlm.nih.gov/gene/513032", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513032", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513032", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR32274", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32274", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32274:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32274:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06818", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06818", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTD3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTD3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQRELLSYLHLPKKDGKTTKRAPRNEPADYATLYYQEHPRAGDFSKTSLPERGRFDKVCLGSSPPYCGRVGRGALLEDPEAGIGHGSLAVGWPGDMYPCSQRGFPGVSGGSTREQSAQSLIPGLSFWQCRIRPSVFKPASGTGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQAQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPSTGPGPFSSSLGHINHLGGSLDRASRGSKEVGPLALLNCLPEPPPPYEFSCPAAEDMGTVVPDTCEELKRSLGEEDGANPFTQVLEERQRLWLAELKRLYLERLHEVTQKAERSERNLQLQLFMAQQDQRRLRKELRAQQGLVPEPRPPGSLPETDPSARAEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGGEARDGAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQVLEQELRVLREPPAPWSPRLESSKI", "length": 614, "header": "tr|A0AAA9SXH1-1|A0AAA9SXH1_BOVIN Isoform 1 of NEDD4 binding protein 3 OS=Bos taurus OX=9913 GN=N4BP3 PE=3 SV=1 CANONICAL=A0AAA9SXH1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1/entry#A0AAA9SXH1-1", "sequence": { "sequence": "MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQRELLSYLHLPKKDGKTTKRAPRNEPADYATLYYQEHPRAGDFSKTSLPERGRFDKVCLGSSPPYCGRVGRGALLEDPEAGIGHGSLAVGWPGDMYPCSQRGFPGVSGGSTREQSAQSLIPGLSFWQCRIRPSVFKPASGTGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQAQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPSTGPGPFSSSLGHINHLGGSLDRASRGSKEVGPLALLNCLPEPPPPYEFSCPAAEDMGTVVPDTCEELKRSLGEEDGANPFTQVLEERQRLWLAELKRLYLERLHEVTQKAERSERNLQLQLFMAQQDQRRLRKELRAQQGLVPEPRPPGSLPETDPSARAEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGGEARDGAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQVLEQELRVLREPPAPWSPRLESSKI", "length": 614, "header": "tr|A0AAA9SXH1-1|A0AAA9SXH1_BOVIN Isoform 1 of NEDD4 binding protein 3 OS=Bos taurus OX=9913 GN=N4BP3 PE=3 SV=1 CANONICAL=A0AAA9SXH1-1" }, "locus": { "chromosome": "7", "start_pos": 39218812, "end_pos": 39216407, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107077.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107077.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088911.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088911.1" } ] } }, { "isoform_ac": "A0ABI0NTD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1/entry#A0ABI0NTD3-1", "sequence": { "sequence": "MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQRELLSYLHLPKKDGKTTKRAPRNEPADYATLYYQEHPRAGDFSKTSLPERGRFDKCRIRPSVFKPASGTGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRASQAQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPSTGPGPFSSSLGHINHLGGSLDRASRGSKEVGPLALLNCLPEPPPPYEFSCPAAEDMGTVVPDTCEELKRSLGEEDGANPFTQVLEERQRLWLAELKRLYLERLHEVTQKAERSERNLQLQLFMAQQDQRRLRKELRAQQGLVPEPRPPGSLPETDPSARAEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELARLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGGEARDGAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQVLEQELRVLREPPAPWSPRLESSKI", "length": 543, "header": "tr|A0ABI0NTD3-1|A0ABI0NTD3_BOVIN Computationally mapped isoform of NEDD4 binding protein 3 OS=Bos taurus OX=9913 GN=N4BP3 PE=3 SV=1 CANONICAL=A0AAA9SXH1-1" }, "locus": { "chromosome": "7", "start_pos": 39218812, "end_pos": 39216407, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089128.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089128.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106572.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106572.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513032", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513032", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], 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} }, { "isoform_ac": "E1BIZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI4/entry#E1BIZ8-1", "sequence": { "sequence": "MAEAQELLLQLQKDNRDGRLRKQELEELVRGLEAESESLTARLLDLSERERGLQRRRSQAARALRGEAREAARERADRARGLLEAAEQRQRDLLFYYGGEQLSQQRAEQQLGTQLAALQKQLELVEAKHTMQAEALRQSARRMEEAWASFQEQSGVLQELQGKVMEAAAALDSSRGGPEPCDSQPRRGQDCAGSLMEEVAKADCEKRLFGAGAAGFRLWALGALQTLLLLPLGVMALPLLYLALVNLGPAPRPWRPGSDAALRRLRYTLAPLLQLRARGLLPA", "length": 283, "header": "tr|E1BIZ8-1|A0AAA9SXI4_BOVIN Computationally mapped isoform of Transmembrane protein 191C OS=Bos taurus OX=9913 GN=TMEM191C PE=4 SV=3 CANONICAL=A0AAA9SXI4-1" }, "locus": { "chromosome": "17", "start_pos": 72205214, "end_pos": 72202848, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031774.5", "url": "https://www.ensembl.org/id/ENSBTAT00000031774.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031720.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031720.5" } ] } } ], "glycosylation": [], 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receptor family 7 subfamily A member 80", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377755" }, "gene_names": [ { "name": "OR7A80", "type": "recommended", "evidence": [ { "id": "A0AAA9SXK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5" } ] }, { "name": "OR7A80", "type": "synonym", "evidence": [ { "id": "NP_001377755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377755" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SXK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 7 subfamily A member 80", "type": "synonym", "evidence": [ { "id": "NP_001377755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377755" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377755" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7A80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5", "locus": { "chromosome": "7", "start_pos": 10196844, "end_pos": 10197710, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057086", "url": "https://www.ensembl.org/id/ENSBTAG00000057086" } ] } } ], "crossref": [ { "id": "A0AAA9SXK5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXK5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "119646113", "url": "https://www.ncbi.nlm.nih.gov/gene/119646113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYLITVFGNLLIILAVSSDFHLHTPMYFFLSNLSFADICFTSTIIPKMLWNIQTHSKVITFEGCIIQMYFFLLFGGLDVFLLTMMAYDRYMAICHPLHYMVIMKPRLCGLLVLSSFIMSFLYALMQSLMVVQLSFCTKQVIPHFFCEANLMIKLACSDTFICDMVVYFVSVVLGGGSLGAILYSYSKIIACINGISSAQGKYKAFSTCASHLSIVSLFSCSVLGVYLTSADTHSSHSSVIASVMYSVVTPMLNPFMYSLRNKDIKKALKIFGKETNKELIVLGLKNCH", "length": 288, "header": "tr|A0AAA9SXK5-1|A0AAA9SXK5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7A80 PE=3 SV=1 CANONICAL=A0AAA9SXK5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5/entry#A0AAA9SXK5-1", "sequence": { "sequence": "MYLITVFGNLLIILAVSSDFHLHTPMYFFLSNLSFADICFTSTIIPKMLWNIQTHSKVITFEGCIIQMYFFLLFGGLDVFLLTMMAYDRYMAICHPLHYMVIMKPRLCGLLVLSSFIMSFLYALMQSLMVVQLSFCTKQVIPHFFCEANLMIKLACSDTFICDMVVYFVSVVLGGGSLGAILYSYSKIIACINGISSAQGKYKAFSTCASHLSIVSLFSCSVLGVYLTSADTHSSHSSVIASVMYSVVTPMLNPFMYSLRNKDIKKALKIFGKETNKELIVLGLKNCH", "length": 288, "header": "tr|A0AAA9SXK5-1|A0AAA9SXK5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7A80 PE=3 SV=1 CANONICAL=A0AAA9SXK5-1" }, "locus": { "chromosome": "7", "start_pos": 10197710, "end_pos": 10196847, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088952.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXK5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": 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"CDD", "categories": [ "Protein Classification" ] }, { "id": "787450", "url": "https://www.ncbi.nlm.nih.gov/gene/787450", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00305", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00305", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836303", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836303", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "41332", "url": "https://www.rhea-db.org/rhea/41332", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50840", "url": "https://www.rhea-db.org/rhea/50840", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKYRIRVATGDSLLAGSSNLVQLWLVGEHGEKDLGKILRPIRIREVQLEVEVSLYLGRLLLVKLRKHKSLVGFDWFCKWIAVQGPGTQGEAFFPCYRWVQGNEIICLPEGTARTVRDDPQNQFKKHREKELEERRKVYRWGFWKEGLILPIAGNTQWDLPRNERFLEDKDLDFSLSLAKVLKDLALKGSLDLTNSVRRLEDFNKVFPQGKTPLAERVRNCWKDDALFGYQFLNGANPMLLRRSTSLPSRLVLPPEMEDLKTQLEKELQTGSLFEADFSLLDGVKPNVIIFKQQYVAAPLVMLKLQPDGRLLPMVIQLQPPRNGCPPPVLFLPSDPPMAWLLAKTWVRSSDFQLHQLQSHLLRGHLIAEVISVATMRSLPSLHPIYKLLIPHFRYTMEINVLARSNLVSKWGIFDLVVSTGSGGHVDILQRATAGLTYRSFCPPDDLADRGLLDVKSSLYGQDALRLWGVISRYVEKMVSLFYKSDGAVKDDPELQAWCREITETGLQGAQDRGFPISLESRAQLCHFITMCIFTCTGQHASTHQGQLDWYSWIPNGPCTMQKPPPISKDVTEKDIVDSLPSLHQARTQKTFIKFLGRRQPVMVALGQHKENYFSDPGPQAVLKQFQEELAALDKEIEVRNAGLDLPYEYLRPSMVENSVTI", "length": 662, "header": "tr|A0AAA9SXL8-1|A0AAA9SXL8_BOVIN Isoform 1 of arachidonate 12-lipoxygenase OS=Bos taurus OX=9913 GN=ALOX12E PE=3 SV=1 CANONICAL=A0AAA9SXL8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8/entry#A0AAA9SXL8-1", "sequence": { "sequence": "MGKYRIRVATGDSLLAGSSNLVQLWLVGEHGEKDLGKILRPIRIREVQLEVEVSLYLGRLLLVKLRKHKSLVGFDWFCKWIAVQGPGTQGEAFFPCYRWVQGNEIICLPEGTARTVRDDPQNQFKKHREKELEERRKVYRWGFWKEGLILPIAGNTQWDLPRNERFLEDKDLDFSLSLAKVLKDLALKGSLDLTNSVRRLEDFNKVFPQGKTPLAERVRNCWKDDALFGYQFLNGANPMLLRRSTSLPSRLVLPPEMEDLKTQLEKELQTGSLFEADFSLLDGVKPNVIIFKQQYVAAPLVMLKLQPDGRLLPMVIQLQPPRNGCPPPVLFLPSDPPMAWLLAKTWVRSSDFQLHQLQSHLLRGHLIAEVISVATMRSLPSLHPIYKLLIPHFRYTMEINVLARSNLVSKWGIFDLVVSTGSGGHVDILQRATAGLTYRSFCPPDDLADRGLLDVKSSLYGQDALRLWGVISRYVEKMVSLFYKSDGAVKDDPELQAWCREITETGLQGAQDRGFPISLESRAQLCHFITMCIFTCTGQHASTHQGQLDWYSWIPNGPCTMQKPPPISKDVTEKDIVDSLPSLHQARTQKTFIKFLGRRQPVMVALGQHKENYFSDPGPQAVLKQFQEELAALDKEIEVRNAGLDLPYEYLRPSMVENSVTI", "length": 662, "header": "tr|A0AAA9SXL8-1|A0AAA9SXL8_BOVIN Isoform 1 of arachidonate 12-lipoxygenase OS=Bos taurus OX=9913 GN=ALOX12E PE=3 SV=1 CANONICAL=A0AAA9SXL8-1" }, "locus": { "chromosome": "19", "start_pos": 26736087, "end_pos": 26727597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091219.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091219.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid oxidation", "id": "GO:0034440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034440", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" }, { "name": "lipoxygenase pathway", "id": "GO:0019372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019372", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" }, { "name": "arachidonate metabolic process", "id": "GO:0019369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019369", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" }, { "name": "arachidonate 12(S)-lipoxygenase activity", "id": "GO:0004052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" }, { "name": "linoleate 13S-lipoxygenase activity", "id": "GO:0016165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "41332", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27479-1", "F1MFA8-1", "F1MQ78-1", "A0AAA9SXL8-1" ], "evidence": [ { "id": "41332", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41332" } ] }, { "id": "50840", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27479-1", "F1MFA8-1", "F1MQ78-1", "A0AAA9SXL8-1" ], "evidence": [ { "id": "50840", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50840" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9SXL8", "gene_name": "ALOX12E", "activity": [ { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "A0AAA9SXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ] }, { "ec_number": "1.13.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" } ] } ] }, { "uniprot_ac": "F1MFA8", "gene_name": "ALOX12", "activity": [ { "ec_number": "1.13.11.31", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] }, { "ec_number": "1.13.11.33", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate.", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] }, { "ec_number": "1.13.11.33", "activity": "", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] }, { "ec_number": "1.13.11.31", "activity": "", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MFA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA8" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { 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"activity": "", "evidence": [ { "id": "P27479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P27479" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" }, { "id": "PS51393", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51393" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipoxygenase", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 662, "start_aa": "Arg", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL8" }, { "id": "PS50095", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50095" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PLAT", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 114, "start_aa": "Gly", "end_aa": "Arg", 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"glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.13.11.31", "ec_name": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate.", "evidence": [ { "id": "1.13.11.31", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31" }, { "id": "1.13.11.31", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.31" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXQ0-1", "uniprot_ac": "A0AAA9SXQ0", "uniprot_id": "A0AAA9SXQ0_BOVIN", "mass": { "chemical_mass": 69863.0, "monoisotopic_mass": 69863.0 }, "refseq": { "ac": "NP_001192728", "name": "kelch-like protein 15", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192728" }, "gene_names": [ { "name": "KLHL15", "type": "recommended", "evidence": [ { "id": "A0AAA9SXQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ] }, { "name": "KLHL15", "type": "synonym", "evidence": [ { "id": "NP_001192728", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192728" } ] } ], "protein_names": [ { "name": "Kelch-like protein 15", "type": "recommended", "evidence": [ { "id": "A0AAA9SXQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0/entry#names_and_taxonomy" } ] }, { "name": "kelch-like 15", "type": "synonym", "evidence": [ { "id": "NP_001192728", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192728" } ] }, { "name": "kelch-like protein 15", "type": "synonym", "evidence": [ { "id": "NP_001192728", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192728" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0", "locus": { "chromosome": "X", "start_pos": 119272918, "end_pos": 119240316, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020561", "url": "https://www.ensembl.org/id/ENSBTAG00000020561" } ] } } ], "crossref": [ { "id": "A0AAA9SXQ0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd18244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18454", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18454", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540246", "url": "https://www.ncbi.nlm.nih.gov/gene/540246", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540246", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540246", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PRHNSWL", "url": "https://omabrowser.org/oma/group/PRHNSWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192728", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGDMEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQNKIHLKGLTATGFSHVLQFMYYGTIELSMSTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNIHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDRQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPEYILDEVRRCN", "length": 604, "header": "tr|A0AAA9SXQ0-1|A0AAA9SXQ0_BOVIN Isoform 1 of Kelch-like protein 15 OS=Bos taurus OX=9913 GN=KLHL15 PE=4 SV=1 CANONICAL=A0AAA9SXQ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0/entry#A0AAA9SXQ0-1", "sequence": { "sequence": "MAGDMEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQNKIHLKGLTATGFSHVLQFMYYGTIELSMSTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNIHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDRQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPEYILDEVRRCN", "length": 604, "header": "tr|A0AAA9SXQ0-1|A0AAA9SXQ0_BOVIN Isoform 1 of Kelch-like protein 15 OS=Bos taurus OX=9913 GN=KLHL15 PE=4 SV=1 CANONICAL=A0AAA9SXQ0-1" }, "locus": { "chromosome": "X", "start_pos": 119269362, "end_pos": 119252679, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120701.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120701.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089007.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540246", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540246", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PIX2-1", "protein_name": "Kelch-like protein 15", "gene_name": "KLHL15", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGDVEGFSSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDSFLLENFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRHEVDQAMNYFHSVHQQPLMEMKSNKIRSAKPQTAVFRGMIGHSMVNSKILLLHKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNTWLRMADMSVPRSEFAVGVIGRYVYAVAGRTRDETFYSTERYDITEDKWEFVDPYPVNKYGHEGTVLGNKLYITGGITSSSTSKQVCVFDPSKEGTVEQRTRRTQVATNCWENKCKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYDPDTDQWTILASMPIGRSGHGVAVLDKQIMVLGGLCYNGHYSDSILTFDPEENKWKEDEYPRMPCKLDGLQVCSLHFPEYVLEHVRRCS", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8D1HS75-1", "protein_name": "Kelch-like protein 15", "gene_name": "KLHL15", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMSTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNIHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPEYILDEVRRCN", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A2AAX3-1", "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZA50-1", "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HQ44-1", "protein_name": "Kelch-like protein 15", "gene_name": "Klhl15", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQALSYFQNIHQQPLIDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDIINDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96M94-1", "protein_name": "Kelch-like protein 15", "gene_name": "KLHL15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVRRCN", "length": 604 }, "evidence": [ { "id": "A0AAA9SXQ0", "url": "https://omabrowser.org/oma/group/A0AAA9SXQ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" }, { "name": "nuclear protein quality control by the ubiquitin-proteasome system", "id": "GO:0071630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXQ0" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 98, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 470, "end_pos": 472 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXS8-1", "uniprot_ac": "A0AAA9SXS8", "uniprot_id": "A0AAA9SXS8_BOVIN", "mass": { "chemical_mass": 35228.0, "monoisotopic_mass": 35228.0 }, "refseq": { "ac": "NP_001377364", "name": "olfactory receptor family 12 subfamily D member 18", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377364" }, "gene_names": [ { "name": "OR12D18", "type": "recommended", "evidence": [ { "id": "A0AAA9SXS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" } ] }, { "name": "OR12D18", "type": "synonym", "evidence": [ { "id": "NP_001377364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377364" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SXS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 12 subfamily D member 18", "type": "synonym", "evidence": [ { "id": "NP_001377364", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377364" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377364" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR12D18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8", "locus": { "chromosome": "23", "start_pos": 29278135, "end_pos": 29279076, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062411", "url": "https://www.ensembl.org/id/ENSBTAG00000062411" } ] } } ], "crossref": [ { "id": "A0AAA9SXS8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15915", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15915", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785712", "url": "https://www.ncbi.nlm.nih.gov/gene/785712", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785712", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785712", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377364", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLFSLFFQVMLNQTSVTEFLLLGVTDIQELQPVLFVIFLATYIVSLAGNGAILMVVISDSRLHSPTYCFLGNLSCLDICYSTVTLPKMLGNFLSTLKTISFLGCISQLHFFHVLGSTESMLLAMMGFDRFVAMCKPLHYTLIMNHQVCIQMAVTVWIIVFFHALLYSVMTSHLNFCGSNHIHHIFCDVKPLLELACGTIELNEWLLNTVTGTIAMGSFFLTFLSYVYIIIYLFFKTHSCSMLHKALSTCASHFSVVVLFFVPVDFVYIHPASSSSVDQDQIIAIMYSVVTPVLNPLIYTLRNKEVKGALRRVM", "length": 313, "header": "tr|A0AAA9SXS8-1|A0AAA9SXS8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D18 PE=3 SV=1 CANONICAL=A0AAA9SXS8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8/entry#A0AAA9SXS8-1", "sequence": { "sequence": "MLFSLFFQVMLNQTSVTEFLLLGVTDIQELQPVLFVIFLATYIVSLAGNGAILMVVISDSRLHSPTYCFLGNLSCLDICYSTVTLPKMLGNFLSTLKTISFLGCISQLHFFHVLGSTESMLLAMMGFDRFVAMCKPLHYTLIMNHQVCIQMAVTVWIIVFFHALLYSVMTSHLNFCGSNHIHHIFCDVKPLLELACGTIELNEWLLNTVTGTIAMGSFFLTFLSYVYIIIYLFFKTHSCSMLHKALSTCASHFSVVVLFFVPVDFVYIHPASSSSVDQDQIIAIMYSVVTPVLNPLIYTLRNKEVKGALRRVM", "length": 313, "header": "tr|A0AAA9SXS8-1|A0AAA9SXS8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR12D18 PE=3 SV=1 CANONICAL=A0AAA9SXS8-1" }, "locus": { "chromosome": "23", "start_pos": 29279076, "end_pos": 29278138, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091280.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785712", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785712", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXS8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 298, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], 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"categories": [ "Protein Classification" ] }, { "id": "IPR029034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336971", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336971", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VSVYWVQ", "url": "https://omabrowser.org/oma/group/VSVYWVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11848:SF226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11848:SF226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00019", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00019", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00688", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00688", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015330550", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SY40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY40-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPLWLCWALWALPLAGPGVALMEEWILDSLLQQLHLSKVPIVDKATVEGLVIPAHVRTQYVALLQRGHGARSRGKRFSQNFREVVGRFLESEASSYLLVFDMEQRLPPRSELVQAVLRLFQEPVPRAALRRHERLFPRSDRARVTVQWLHVRDDGSNRTALIDSRLVTIHESGWKALDVTEAVNFWQQLRSPRQPLLLQVLVQREHLGPLASSAHRLVRFAPQGPSSGRQGEPQLELHTLDLRDYGAQGNCDPKAPVTKGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCQQPPESLTFKWPFLGPRQCIASETTSLPMIVSIQEGGRLQPHVVSLPNMRVQTCSCASDGALVPRKLEP", "length": 367, "header": "tr|A0AAA9SY40-1|A0AAA9SY40_BOVIN Isoform 1 of Left-right determination factor OS=Bos taurus OX=9913 GN=LOC100336971 PE=3 SV=1 CANONICAL=A0AAA9SY40-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SY40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY40/entry#A0AAA9SY40-1", "sequence": { "sequence": "MQPLWLCWALWALPLAGPGVALMEEWILDSLLQQLHLSKVPIVDKATVEGLVIPAHVRTQYVALLQRGHGARSRGKRFSQNFREVVGRFLESEASSYLLVFDMEQRLPPRSELVQAVLRLFQEPVPRAALRRHERLFPRSDRARVTVQWLHVRDDGSNRTALIDSRLVTIHESGWKALDVTEAVNFWQQLRSPRQPLLLQVLVQREHLGPLASSAHRLVRFAPQGPSSGRQGEPQLELHTLDLRDYGAQGNCDPKAPVTKGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCQQPPESLTFKWPFLGPRQCIASETTSLPMIVSIQEGGRLQPHVVSLPNMRVQTCSCASDGALVPRKLEP", "length": 367, "header": "tr|A0AAA9SY40-1|A0AAA9SY40_BOVIN Isoform 1 of Left-right determination factor OS=Bos taurus OX=9913 GN=LOC100336971 PE=3 SV=1 CANONICAL=A0AAA9SY40-1" }, "locus": { "chromosome": "16", "start_pos": 28967780, "end_pos": 28964094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": 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"A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWJ8", "url": "https://www.uniprot.org/uniprotkb/F1MWJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MWJ8-1", "url": "https://www.uniprot.org/uniprotkb/F1MWJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRTREDELLWPLALGPVARDQVPSISPVLSSLFPNQRLDWTDLKREPQLELEQSSMTRLASGPEGPAVTSRPQDGDSPSSDSPPFYKPSFSWDTLASSYGHSYRQAPSTMQSAFLERSVSLYGSPLVPSAEPPLDFSLHYSPGMDAYHCIKCSKVFSTPHGLEVHARRSHSGTRPFACNVCGKTFGHSVSLEQHTHVHSQATPTECPVPQGIPAGSSPAPTPDPPGPRFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCAKGFQRKVDLRRHRESQHNLK", "length": 363, "header": "tr|A0AAA9SYB3-1|A0AAA9SYB3_BOVIN Isoform 1 of Growth factor independent 1B transcriptional repressor OS=Bos taurus OX=9913 GN=GFI1B PE=4 SV=1 CANONICAL=A0AAA9SYB3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3/entry#A0AAA9SYB3-1", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRTREDELLWPLALGPVARDQVPSISPVLSSLFPNQRLDWTDLKREPQLELEQSSMTRLASGPEGPAVTSRPQDGDSPSSDSPPFYKPSFSWDTLASSYGHSYRQAPSTMQSAFLERSVSLYGSPLVPSAEPPLDFSLHYSPGMDAYHCIKCSKVFSTPHGLEVHARRSHSGTRPFACNVCGKTFGHSVSLEQHTHVHSQATPTECPVPQGIPAGSSPAPTPDPPGPRFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCAKGFQRKVDLRRHRESQHNLK", "length": 363, "header": "tr|A0AAA9SYB3-1|A0AAA9SYB3_BOVIN Isoform 1 of Growth factor independent 1B transcriptional repressor OS=Bos taurus OX=9913 GN=GFI1B PE=4 SV=1 CANONICAL=A0AAA9SYB3-1" }, "locus": { "chromosome": "11", "start_pos": 103011510, "end_pos": 103007295, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089248.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089248.1" } ] } }, { "isoform_ac": "A0AAA9T5Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3/entry#A0AAA9T5Q0-1", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRTREDELLWPLALGPVARDQVPSISPVLSSLFPNQRLDWTDLKREPQLELEQSSMTRLASGPEGPAVTSRPQDGDSPSSDSPPFYKPSFSWDTLASSYGHSYRQAPSTMQSAFLERSVSLYGSPLVPSAEPPLDFSLHYSPGMDAYHCIKCSKERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCAKGFQRKVDLRRHRESQHNLK", "length": 285, "header": "tr|A0AAA9T5Q0-1|A0AAA9T5Q0_BOVIN Computationally mapped isoform of Growth factor independent 1B transcriptional repressor OS=Bos taurus OX=9913 GN=GFI1B PE=4 SV=1 CANONICAL=A0AAA9SYB3-1" }, "locus": { "chromosome": "11", "start_pos": 103011510, "end_pos": 103007295, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092313.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092313.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091076.1" } ] } }, { "isoform_ac": "F1MWJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3/entry#F1MWJ8-1", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRTREDELLWPLALGPVARDQVPSISPVLSSLFPNQRLDWTDLKREPQLELEQSSMTRLASGPEGPAVTSRPQDGDSPSSDSPPFYKPSFSWDTLASSYGHSYRQAPSTMQSAFLERSVSLYGSPLVPSAEPPLDFSLHYSPGMDAYHCIKCSKVFSTPHGLEVHARRSHSGTRPFACNVCGKTFGHSVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCAKGFQRKVDLRRHRESQHNLK", "length": 331, "header": "tr|F1MWJ8-1|A0AAA9SYB3_BOVIN Computationally mapped isoform of Growth factor independent 1B transcriptional repressor OS=Bos taurus OX=9913 GN=GFI1B PE=4 SV=2 CANONICAL=A0AAA9SYB3-1" }, "locus": { "chromosome": "11", "start_pos": 103011510, "end_pos": 103007295, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016974.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016974.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016974.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016974.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 238, "start_aa": "Thr", "end_pos": 238, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr238", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:537773", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537773", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8J8XL46-1", "protein_name": "Growth factor independent 1B transcriptional repressor", "gene_name": "Gfi1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRAQGDDLVWPPAVIPVAKEHTQSGSPVLSTLLPSQTLDWSAVKQKQEMLLNQSLPKMASAPEGPHVTSQPQDGESPLSESPPFYKPSFSWDTLASSYRHSYQQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFSLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQGVPARSSPSPSLAVPGLEAPPAPDPPRPRFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK", "length": 363 }, "evidence": [ { "id": "A0AAA9SYB3", "url": "https://omabrowser.org/oma/group/A0AAA9SYB3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AHS2-1", "protein_name": "Growth factor independent 1B transcriptional repressor", "gene_name": "GFI1B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQHRFVEDDLPIFTWDPITSAFTAAGDRDKTPEDGKKQDLEWVVPKQEKDSFQPKEESVPVQYLSRMLPGPSAQDVSISGLQVKDCTNPTSVPTFYKTGFSWDAFQLPYSYRQMSSTMQSALLEHPVSLYGSHLLPSAEPPLDYSMRYSSDMETYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACEVCGKTFGHAVSLEQHTNIHSQERSFECKMCGKTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCAKGFQRKVDLRRHRETQHSLK", "length": 337 }, "evidence": [ { "id": "A0AAA9SYB3", "url": "https://omabrowser.org/oma/group/A0AAA9SYB3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7G7Q7-1", "protein_name": "Zinc finger protein Gfi-1b", "gene_name": "Gfi1b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRAQDDDLVWPPAVIPVVKEHILSSSPVLGTLLPSQTLDWNIVKQEQEMLLDQNLPKMASAPEGPLVTSQPQDGESPVSESPPFYKPSFSWDTLASSYNHSYQQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFSLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQGVPTGSSPVPSLAVPGLEAPPAPDPPGPRFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK", "length": 363 }, "evidence": [ { "id": "A0AAA9SYB3", "url": "https://omabrowser.org/oma/group/A0AAA9SYB3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5VTD9-1", "protein_name": "Zinc finger protein Gfi-1b", "gene_name": "GFI1B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK", "length": 330 }, "evidence": [ { "id": "A0AAA9SYB3", "url": "https://omabrowser.org/oma/group/A0AAA9SYB3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYB3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 164, "end_pos": 192, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 238 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYC9-1", "uniprot_ac": "A0AAA9SYC9", "uniprot_id": "A0AAA9SYC9_BOVIN", "mass": { "chemical_mass": 21421.0, "monoisotopic_mass": 21421.0 }, "refseq": {}, "gene_names": [ { "name": "LGALS7B", "type": "recommended", "evidence": [ { "id": "A0AAA9SYC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9" } ] } ], "protein_names": [ { "name": "Galectin", "type": "recommended", "evidence": [ { "id": "A0AAA9SYC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9#function" }, { "database": "UniProtKB", "id": "ARBA00055823", "url": "https://www.uniprot.org/uniprotkb/ARBA00055823#function" }, { "database": "UniProtKB", "id": "A0ABI0NYG2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LGALS7B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9", "locus": {} } ], "crossref": [ { "id": "A0AAA9SYC9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYC9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00070", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00070", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100298130", "url": "https://www.ncbi.nlm.nih.gov/gene/100298130", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11346:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11346:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGASEALERGCWASMAPGSVPGVGGGCGKAESPGPGTPCFDLRSQQPRPHCHCRPAVPAMAGSFNVPHKTSLPEGIRVGTVLRIRGLVPDKAGRFYMNLLCGEEPGSDAALHFNPRLDESTVVFNTLERGTWGAEERGSGIPFQRGQPFDVLLIATEEGFKVVIADSEYHHFRYRIPPGRVRALEVGGDLQLELVKIF", "length": 199, "header": "tr|A0AAA9SYC9-1|A0AAA9SYC9_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=LGALS7B PE=4 SV=1 CANONICAL=A0AAA9SYC9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9/entry#A0AAA9SYC9-1", "sequence": { "sequence": "MAGASEALERGCWASMAPGSVPGVGGGCGKAESPGPGTPCFDLRSQQPRPHCHCRPAVPAMAGSFNVPHKTSLPEGIRVGTVLRIRGLVPDKAGRFYMNLLCGEEPGSDAALHFNPRLDESTVVFNTLERGTWGAEERGSGIPFQRGQPFDVLLIATEEGFKVVIADSEYHHFRYRIPPGRVRALEVGGDLQLELVKIF", "length": 199, "header": "tr|A0AAA9SYC9-1|A0AAA9SYC9_BOVIN Isoform 1 of Galectin OS=Bos taurus OX=9913 GN=LGALS7B PE=4 SV=1 CANONICAL=A0AAA9SYC9-1" }, "locus": { "chromosome": "18", "start_pos": 48527675, "end_pos": 48525359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090370.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090370.1" } ] } }, { "isoform_ac": "A0ABI0NYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9/entry#A0ABI0NYG2-1", "sequence": { "sequence": "MAGSFNVPHKTSLPEGIRVGTVLRIRGLVPDKAGRFYMNLLCGEEPGSDAALHFNPRLDESTVVFNTLERGTWGAEERGSGIPFQRGQPFDVLLIATEEGFKVVIADSEYHHFRYRIPPGRVRALEVGGDLQLELVKIF", "length": 139, "header": "tr|A0ABI0NYG2-1|A0ABI0NYG2_BOVIN Computationally mapped isoform of Galectin OS=Bos taurus OX=9913 GN=LGALS7B PE=4 SV=1 CANONICAL=A0AAA9SYC9-1" }, "locus": { "chromosome": "18", "start_pos": 48527675, "end_pos": 48525539, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147742.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147742.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105320.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105320.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYC9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYC9" }, { "id": "PS51304", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51304" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Galectin", "eco_id": "ECO_0000259", "start_pos": 69, "end_pos": 199, "start_aa": "His", "end_aa": "Phe", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYD8-1", "uniprot_ac": "A0AAA9SYD8", "uniprot_id": "A0AAA9SYD8_BOVIN", "mass": { "chemical_mass": 87180.0, "monoisotopic_mass": 87180.0 }, "refseq": {}, "gene_names": [ { "name": "ZSCAN10", "type": "recommended", "evidence": [ { "id": "A0AAA9SYD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ] } ], "protein_names": [ { "name": "Zinc finger and SCAN domain-containing protein 10", "type": "recommended", "evidence": [ { "id": "A0AAA9SYD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 206", "type": "synonym", "evidence": [ { "id": "A0AAA9SYD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8#function" }, { "database": "UniProtKB", "id": "ARBA00057877", "url": "https://www.uniprot.org/uniprotkb/ARBA00057877#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZSCAN10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8", "locus": { "chromosome": "25", "start_pos": 2539811, "end_pos": 2549257, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034238", "url": "https://www.ensembl.org/id/ENSBTAG00000034238" } ] } } ], "crossref": [ { "id": "A0AAA9SYD8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050916", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050916", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BA35", "url": "https://www.orthodb.org/?gene=E1BA35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF159", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF159", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45935:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45935:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA35", "url": "https://www.uniprot.org/uniprotkb/E1BA35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA35-1", "url": "https://www.uniprot.org/uniprotkb/E1BA35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAEPSPAAGEPEQLGAVKLEEEEEAASQEDPGRPEARPRPEVAHQLFRCFQYQEDMGPRASLSRLRELCNHWLRPALHTKKQILELLVLEQFLSVLPPHLLARLQGQQLRDGEEVVLLLEGVQRESSNVGPLDFSFNAGKNCPRADVTLEEQGGSFQVSSHSPKKEAASEGPPALEPSQALPPSQSGPSKPAEMGDWRRPLSSRQPLSPGPKRTLQAPQESVPSALQGPELWPEESSGDQELAAVLESLTFEDVPAKKAWPVHPLGTGGRTLEEAFKAEEPKGVSWPSAASANSQAESPRVAEEPHAQSLGSGPETSSPGGEMSPPGRSDVLKVKAAEDAPKSDPEFKFICTDCGISFPQLARLEAHQLRSHPGARSFLCLCCGKAFGRSSILKLHMRTHTDERPHTCHLCGHRFRQSSHLNKHLQTHSSEPAFLCAECGQGFQRRARLTQHLLAHAQDQKPPGGTPETKPPAPPELTVVLCSHCGQTFQRRSSLKRHLRIHAKDKGHQCSECSGSLRPGPERRPYVCGECGKAFRRSEHLGAHWRVHTGERPFSCQVCGRSFSQSSQLVCHQRVHTGEKPYGCPHCGKRFMRRAGLARHLLTHGGPRPHHCTQCGKSFSQTQDLARHRRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHVCDTCGHRFRNSSNLARHRRSHTGERPYSCEQCGRSFRRNAHLQRHLATHAGAGDEAASGPAEPPQECPECGKVFSRSCNLLRHMLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY", "length": 789, "header": "tr|A0AAA9SYD8-1|A0AAA9SYD8_BOVIN Isoform 1 of Zinc finger and SCAN domain-containing protein 10 OS=Bos taurus OX=9913 GN=ZSCAN10 PE=4 SV=1 CANONICAL=A0AAA9SYD8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8/entry#A0AAA9SYD8-1", "sequence": { "sequence": "MLAEPSPAAGEPEQLGAVKLEEEEEAASQEDPGRPEARPRPEVAHQLFRCFQYQEDMGPRASLSRLRELCNHWLRPALHTKKQILELLVLEQFLSVLPPHLLARLQGQQLRDGEEVVLLLEGVQRESSNVGPLDFSFNAGKNCPRADVTLEEQGGSFQVSSHSPKKEAASEGPPALEPSQALPPSQSGPSKPAEMGDWRRPLSSRQPLSPGPKRTLQAPQESVPSALQGPELWPEESSGDQELAAVLESLTFEDVPAKKAWPVHPLGTGGRTLEEAFKAEEPKGVSWPSAASANSQAESPRVAEEPHAQSLGSGPETSSPGGEMSPPGRSDVLKVKAAEDAPKSDPEFKFICTDCGISFPQLARLEAHQLRSHPGARSFLCLCCGKAFGRSSILKLHMRTHTDERPHTCHLCGHRFRQSSHLNKHLQTHSSEPAFLCAECGQGFQRRARLTQHLLAHAQDQKPPGGTPETKPPAPPELTVVLCSHCGQTFQRRSSLKRHLRIHAKDKGHQCSECSGSLRPGPERRPYVCGECGKAFRRSEHLGAHWRVHTGERPFSCQVCGRSFSQSSQLVCHQRVHTGEKPYGCPHCGKRFMRRAGLARHLLTHGGPRPHHCTQCGKSFSQTQDLARHRRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHVCDTCGHRFRNSSNLARHRRSHTGERPYSCEQCGRSFRRNAHLQRHLATHAGAGDEAASGPAEPPQECPECGKVFSRSCNLLRHMLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY", "length": 789, "header": "tr|A0AAA9SYD8-1|A0AAA9SYD8_BOVIN Isoform 1 of Zinc finger and SCAN domain-containing protein 10 OS=Bos taurus OX=9913 GN=ZSCAN10 PE=4 SV=1 CANONICAL=A0AAA9SYD8-1" }, "locus": { "chromosome": "25", "start_pos": 2544972, "end_pos": 2540750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089107.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089107.1" } ] } }, { "isoform_ac": "E1BA35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8/entry#E1BA35-1", "sequence": { "sequence": "MLAEPSPAAGEPEQLGAVKLEEEEEAASQEDPGRPEARPRPEVAHQLFRCFQYQEDMGPRASLSRLRELCNHWLRPALHTKKQILELLPSRAPSCGQRRAREIRSWQQCWSP", "length": 112, "header": "tr|E1BA35-1|E1BA35_BOVIN Computationally mapped isoform of Zinc finger and SCAN domain containing 10 OS=Bos taurus OX=9913 GN=ZSCAN10 PE=4 SV=3 CANONICAL=A0AAA9SYD8-1" }, "locus": { "chromosome": "25", "start_pos": 2544972, "end_pos": 2543531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037528.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037528.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037357.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037357.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 467, "start_aa": "Thr", "end_pos": 467, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr467", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 678, "end_pos": 680, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 350, "end_pos": 378, "start_aa": "Phe", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9SYD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYD8" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 126, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 467 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 678, "end_pos": 680 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYE7-1", "uniprot_ac": "A0AAA9SYE7", "uniprot_id": "A0AAA9SYE7_BOVIN", "mass": { "chemical_mass": 52527.0, "monoisotopic_mass": 52527.0 }, "refseq": { "ac": "XP_059730851", "name": "secretion-regulating guanine nucleotide exchange factor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730851" }, "gene_names": [ { "name": "SERGEF", "type": "recommended", "evidence": [ { "id": "A0AAA9SYE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ] }, { "name": "SERGEF", "type": "synonym", "evidence": [ { "id": "XP_059730851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730851" } ] } ], "protein_names": [ { "name": "Secretion-regulating guanine nucleotide exchange factor", "type": "recommended", "evidence": [ { "id": "A0AAA9SYE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#names_and_taxonomy" } ] }, { "name": "secretion-regulating guanine nucleotide exchange factor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059730851", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730851" } ] } ], "function": [ { "annotation": "Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7#function" }, { "database": "UniProtKB", "id": "ARBA00053612", "url": "https://www.uniprot.org/uniprotkb/ARBA00053612#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ28#function" }, { "database": "UniProtKB", "id": "A0AAA9TQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY1#function" }, { "database": "UniProtKB", "id": "A0AAF6YNF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNF7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SERGEF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7", "locus": { "chromosome": "15", "start_pos": 34730575, "end_pos": 34481913, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005340", "url": "https://www.ensembl.org/id/ENSBTAG00000005340" } ] } } ], "crossref": [ { "id": "A0AAA9SYE7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYE7", "database": "AlphaFoldDB", "categories": [] }, { "id": "534377", "url": "https://www.ncbi.nlm.nih.gov/gene/534377", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22870", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22870", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22870:SF408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22870:SF408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22870:SF466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22870:SF466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00415", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00415", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059730851", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNF7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YNF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YNF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGDLPDPRIKPMSPVAPALAGGYFTTEPPGKPLAMPGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 499, "header": "tr|A0AAA9SYE7-1|A0AAA9SYE7_BOVIN Isoform 1 of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9SYE7-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGDLPDPRIKPMSPVAPALAGGYFTTEPPGKPLAMPGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 499, "header": "tr|A0AAA9SYE7-1|A0AAA9SYE7_BOVIN Isoform 1 of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34481938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087899.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087899.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088358.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088358.1" } ] } }, { "isoform_ac": "A0AAA9T0K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9T0K2-1", "sequence": { "sequence": "NTCPPSLDQHHFRCKGNSSEKNKGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 467, "header": "tr|A0AAA9T0K2-1|A0AAA9T0K2_BOVIN Computationally mapped isoform of Secretion regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34484049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089905.1" } ] } }, { "isoform_ac": "A0AAA9TI95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9TI95-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 443, "header": "tr|A0AAA9TI95-1|A0AAA9TI95_BOVIN Computationally mapped isoform of Secretion regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34481938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099000.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099000.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096826.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096826.1" } ] } }, { "isoform_ac": "A0AAA9TJ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9TJ28-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTGLPDVRTCYVAPGRVWTVNRTERLKKIRAQNPAPPSAISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 445, "header": "tr|A0AAA9TJ28-1|A0AAA9TJ28_BOVIN Computationally mapped isoform of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34481938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133154.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133154.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096245.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096245.1" } ] } }, { "isoform_ac": "A0AAA9TQY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9TQY1-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTAHIGTHLGVVSIAPVVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 479, "header": "tr|A0AAA9TQY1-1|A0AAA9TQY1_BOVIN Computationally mapped isoform of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34481938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095882.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095882.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099418.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099418.1" } ] } }, { "isoform_ac": "A0AAA9TRU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAA9TRU8-1", "sequence": { "sequence": "GCLQSLTTGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 452, "header": "tr|A0AAA9TRU8-1|A0AAA9TRU8_BOVIN Computationally mapped isoform of Secretion regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34484880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129597.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129597.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099760.1" } ] } }, { "isoform_ac": "A0AAF6YNF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7/entry#A0AAF6YNF7-1", "sequence": { "sequence": "MEPEPHSSEAVPTAAALFAWGANSYGQLGLGHKEDVLSAQQLSDFCKSGCIKRITGGGGHSAVVTDEGSLFVCGLNKDGQLGLGHTEEVLYFTPCKSLLGCAIQQVACGWDFTIILTENGQVLSCGSNSFGQLGVPHGPRRCVIPQAIELLREKVVSIAAGLRHALAATASGTVFQWGTGLASSGRRLCPGQTLPLFLTAKEPSTVTGLENSQAVCVLAGSDHSASLTDAGELYVWGSNKHGQLASQAAFLLLPQRIEARCFQNEKIAAVWSGWTHLVAQTVTGKVFTWGRADYGQLGRTVETREGWESEKQDPSLPGSGPQKGTPSCLPCLTGATEISSDQSGKGTNISCGSEHNLAVIGGVCHSWGWNEHGMCGDGTEADVWAPKPVPGLRFFLGLHVGCGAGHSLALCQLPALPALGQHPSVTSPSPDATKEARSQEAMEQERNQKERHAETSPQAQSDRFRNGGLVAETLE", "length": 475, "header": "tr|A0AAF6YNF7-1|A0AAF6YNF7_BOVIN Computationally mapped isoform of Secretion-regulating guanine nucleotide exchange factor OS=Bos taurus OX=9913 GN=SERGEF PE=4 SV=1 CANONICAL=A0AAA9SYE7-1" }, "locus": { "chromosome": "15", "start_pos": 34730035, "end_pos": 34481938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007022.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007022.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007022.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007022.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of protein secretion", "id": "GO:0050709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050709", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE7" }, { "id": "PF25390", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RCC1-like", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 349, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYG2-1", "uniprot_ac": "A0AAA9SYG2", "uniprot_id": "A0AAA9SYG2_BOVIN", "mass": { "chemical_mass": 53786.0, "monoisotopic_mass": 53786.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Patatin like phospholipase domain containing 5", "type": "synonym", "evidence": [ { "id": "A0AAA9SYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SYG2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR002641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12406:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12406:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01734", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01734", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRYSLLFKNFPQFVVIHTVKGFSIVNEAEVDFSGILFLLCTPIWSRSFAGAAFLGLYHVGVIHRLSRFYGSSSGALIAVSIVSGLSVDLCCSLILAMVKRVEQLSLGIFHPTFMPIETIRQDLQDSLPTDIHILASQRLGISLTHWPEGKNFIVTDFATRDEVIEALVCTAYFPFYCGTIPPTFRGKVSALRGLTTTCPLRTHPPPNGMVDICPQSSSASIHEMNAFSANFQISTKNLFRGITCLIPSSLEVMANSCRQGYLDALRFLERRGLTKEPVLWSLVSKEPPAPADGTPDAAHDRGLSLNWAVPNVLVKDVPDFEQLSPELEAALKKACMRDPSAWASFCRSGPGWALTYLLLPFEYVYFQSRRLVEWLPDMPADLWWMQGLLRSLALEVCSRTKDQLLRLLHPIPGSENSPLLASASSAASLSPAPSSLRPLLPRTWPRNPDLPIRPEGTVPAQPSDWPPLTPIMALVPCPHLPLVLES", "length": 487, "header": "tr|A0AAA9SYG2-1|A0AAA9SYG2_BOVIN Isoform 1 of Patatin like phospholipase domain containing 5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SYG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG2/entry#A0AAA9SYG2-1", "sequence": { "sequence": "MVRYSLLFKNFPQFVVIHTVKGFSIVNEAEVDFSGILFLLCTPIWSRSFAGAAFLGLYHVGVIHRLSRFYGSSSGALIAVSIVSGLSVDLCCSLILAMVKRVEQLSLGIFHPTFMPIETIRQDLQDSLPTDIHILASQRLGISLTHWPEGKNFIVTDFATRDEVIEALVCTAYFPFYCGTIPPTFRGKVSALRGLTTTCPLRTHPPPNGMVDICPQSSSASIHEMNAFSANFQISTKNLFRGITCLIPSSLEVMANSCRQGYLDALRFLERRGLTKEPVLWSLVSKEPPAPADGTPDAAHDRGLSLNWAVPNVLVKDVPDFEQLSPELEAALKKACMRDPSAWASFCRSGPGWALTYLLLPFEYVYFQSRRLVEWLPDMPADLWWMQGLLRSLALEVCSRTKDQLLRLLHPIPGSENSPLLASASSAASLSPAPSSLRPLLPRTWPRNPDLPIRPEGTVPAQPSDWPPLTPIMALVPCPHLPLVLES", "length": 487, "header": "tr|A0AAA9SYG2-1|A0AAA9SYG2_BOVIN Isoform 1 of Patatin like phospholipase domain containing 5 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9SYG2-1" }, "locus": { "chromosome": "5", "start_pos": 114575279, "end_pos": 114562832, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091503.1", "url": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6Y4-1", "url": "https://www.uniprot.org/uniprotkb/G3X6Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFSSLVCVLFFFLGVKVYCQYESYQWDEDYDQEPDDVYQTEFQFQQNINYEAPFHQHTLGCASECFCPPNFPSSMYCDNRKLKTIPNIPAHIQQVYLQFNEIEAVTADSFINATHLKEINLSHNKIKSQKIDHGVFAKLPNLLQLHLQHNNLEDFPFPLPKSLERIFLGYNEISRLQTNAVNGLVNLTMLDLCFNKIDDSVLQEKVLAKMEKLMQLNLCNNRLESMPPGLPSSLMYLSLENNSISSIPENYFNKLPKLHALRISHNKLQDIPYNIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLENNEIENVNVTVMCPSVDPLHYHHLTHIRIDQNKLKAPISSYIFLCFPHIHTIYYGEQQSTNGQTIQLKTQVFRRFQDDGDSEDHDDHHEGPEEEGTEENIDAHYYGSQEWQETI", "length": 422, "header": "tr|A0AAA9SYU0-1|A0AAA9SYU0_BOVIN Isoform 1 of Osteomodulin OS=Bos taurus OX=9913 GN=OMD PE=3 SV=1 CANONICAL=A0AAA9SYU0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0/entry#A0AAA9SYU0-1", "sequence": { "sequence": "MGFSSLVCVLFFFLGVKVYCQYESYQWDEDYDQEPDDVYQTEFQFQQNINYEAPFHQHTLGCASECFCPPNFPSSMYCDNRKLKTIPNIPAHIQQVYLQFNEIEAVTADSFINATHLKEINLSHNKIKSQKIDHGVFAKLPNLLQLHLQHNNLEDFPFPLPKSLERIFLGYNEISRLQTNAVNGLVNLTMLDLCFNKIDDSVLQEKVLAKMEKLMQLNLCNNRLESMPPGLPSSLMYLSLENNSISSIPENYFNKLPKLHALRISHNKLQDIPYNIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLENNEIENVNVTVMCPSVDPLHYHHLTHIRIDQNKLKAPISSYIFLCFPHIHTIYYGEQQSTNGQTIQLKTQVFRRFQDDGDSEDHDDHHEGPEEEGTEENIDAHYYGSQEWQETI", "length": 422, "header": "tr|A0AAA9SYU0-1|A0AAA9SYU0_BOVIN Isoform 1 of Osteomodulin OS=Bos taurus OX=9913 GN=OMD PE=3 SV=1 CANONICAL=A0AAA9SYU0-1" }, "locus": { "chromosome": "8", "start_pos": 84047250, "end_pos": 84044977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134800.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134800.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088537.1" } ] } }, { "isoform_ac": "G3X6Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0/entry#G3X6Y4-1", "sequence": { "sequence": "MKSWMRRVEKNGLRIKGQKRNMGFSSLVCVLFFFLGVKVYCQYESYQWDEDYDQEPDDVYQTEFQFQQNINYEAPFHQHTLGCASECFCPPNFPSSMYCDNRKLKTIPNIPAHIQQVYLQFNEIEAVTADSFINATHLKEINLSHNKIKSQKIDHGVFAKLPNLLQLHLQHNNLEDFPFPLPKSLERIFLGYNEISRLQTNAVNGLVNLTMLDLCFNKIDDSVLQEKVLAKMEKLMQLNLCNNRLESMPPGLPSSLMYLSLENNSISSIPENYFNKLPKLHALRISHNKLQDIPYNIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLENNEIENVNVTVMCPSVDPLHYHHLTHIRIDQNKLKAPISSYIFLCFPHIHTIYYGEQQSTNGQTIQLKTQVFRRFQDDGDSEDHDDHHEGPEEEGTEENIDAHYYGSQEWQETI", "length": 443, "header": "tr|G3X6Y4-1|G3X6Y4_BOVIN Computationally mapped isoform of Osteomodulin OS=Bos taurus OX=9913 GN=OMD PE=3 SV=2 CANONICAL=A0AAA9SYU0-1" }, "locus": { "chromosome": "8", "start_pos": 84048530, "end_pos": 84044977, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015704.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015704.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015704.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015704.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2022854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "resource": "Reactome", "description": "Keratan sulfate biosynthesis" }, { "id": "R-BTA-2022857", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022857", "resource": "Reactome", "description": "Keratan sulfate degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AAG8-1", "protein_name": "Osteomodulin", "gene_name": "OMD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGILSQLSILYLLWTTTVFCQYEDYDFGDEYDEPDHQQPYYSNSNPSAQAEVPHFPFPVECARECFCPPEFPLSMYCDHRKLKTIPNIPAHVQQLYLQNNDIEAVPAGPFTNVTILREINLSYNKIKFHMIDHGVFAKLSNLVQLHLHHNELDEFPFPLPSSLERLLLGFNKISKLPGIALDGLANITMLDLCSNFLDDSVLKGNPFSAMNNLMQLNLCNNKLQTMPPNLPSSLMYLSLENNSISYIPENYFSKLPKIIALRMSHNNLQNIPRNTFISLPNLIELNLGHNKLKQVFYIPRSLQHLYIEDNDIEMINVTLMCPSIDLMNINQLTYIRVDQNKLTTPISTYAFFCFPHIRTIYYGEQNSNANKSTQIRAPVFRRLLTPEEYDEIEDDHEIHDQETEEEHEAENNYFYPHFW", "length": 419 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SUE2-1", "protein_name": "Osteomodulin", "gene_name": "OMD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGFSSPVCVLLFFLGVKVYCQYESYQWDEDYDQEPDDVYQPEFQFRQNVDYRVPFPQHTLGCPSECFCPPNFPSSMYCDNRKLKTIPNIPPYIQQVYLQFNEIEAVTADSFINATHLKEINLSHNKIKSQKMDHGVFAKLSNLLQLHLHHNNLEEFPFPLPKSLERILLGYNEISRLQTNAMDGLVNLTMLDLCYNQIDDSMLQEKILGKMEKLMQLNLCNNRLESMPPGLPSSLMYLSLENNSISSIPENYFNELPKLHALRMSHNKLQDIPCNIFNLSNLVELNVGHNKLKQAFYIPRNLEHLYLENNEIENINVTVMCPSVNPLHYHHLTYIRLDQNKLKEPISSYILLCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRFQDDADSEDHDDHQEGPEEEGSEEHVDPHYYGGQEWQETI", "length": 422 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F6NL91-1", "protein_name": "Osteomodulin", "gene_name": "omd", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTLAQLLTILCLFLLTGVLVFSQDYEETNYSDYDTDAISLPEAPPLSVTQQPDYDSQLIYSYDCARECFCPSSYPFAMYCDHQKLKEVPNIPRHIRHLYIQHNDIEEITSKPFINATSLREINLSYNKLQSSKVDKDVFKRLKDLTQLHLEHNNLEDIPSPLPKTLKRLHLGFNKISKIAADATRELTKLTVLDLGSNRLTDASIKGKILSGMKSLMQIILCNNKLKSMPADLPESIQQISLENNSIVSIPEGYFKKTPNLVSLRMPHNKLKSVAYNAFNLSKLMELHLGHNQLSKPFFVPRNLEHLYLNHNDFKDLNISLMCPSLDLGHPNMLTYIRLDNNKLSGPVDYYAYRCFPRLIMIFYGHQRKDDEDDSEKSPKKYEKPDRPKKPGGSKAIDTEV", "length": 401 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O35103-1", "protein_name": "Osteomodulin", "gene_name": "Omd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFLSPIYVLFFCFGVRVYCQYEAYRWDDDYDQEPNEDYDPEFQFHQNIEYGVPFYNNILGCAKECFCPTNFPTSMYCDNRKLKTIPIIPMHIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDSMLKEKTLSKMEKLMQLNLCNNRLESMPLGLPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIESINVTMICPSPDPVHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIYYGEQRSTNGETIQLKTQVFRSYQEEEEEDDHDSQDNTLEGQEVSDEHYNSHYYEMQEWQDTI", "length": 423 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99983-1", "protein_name": "Osteomodulin", "gene_name": "OMD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFLSPIYVIFFFFGVKVHCQYETYQWDEDYDQEPDDDYQTGFPFRQNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRFPDDDDESEDHDDPDNAHESPEQEGAEGHFDLHYYENQE", "length": 421 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1S7-1", "protein_name": "Osteomodulin", "gene_name": "Omd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGCLRPIYVLFFCFVVRVYGQYEAYQWDEDYEQEPSEDYEPEFQFHQNIEYGAPFYQNILGCAKECFCPTNFPTSMYCDNRKLKTIPDIPMHIQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLDHNNLEEFPFPLPKSLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHLSDSTLKGKILSKLEKLMQLNLCNNRLESMPPGLPLSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIQSINVTMMCPSLDPLHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIYYGEQRSTNGETIQLKTQVFRRYQDEEEEEEDDSQDHTLEGQEETEEHFNSHYYEMQAWQNTI", "length": 423 }, "evidence": [ { "id": "A0AAA9SYU0", "url": "https://omabrowser.org/oma/group/A0AAA9SYU0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 242, "end_pos": 244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU0" }, { "id": "SM00013", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00013" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRNT", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 95, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 121, "end_pos": 123 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 242, "end_pos": 244 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 316, "end_pos": 318 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYV2-1", "uniprot_ac": "A0AAA9SYV2", "uniprot_id": "A0AAA9SYV2_BOVIN", "mass": { "chemical_mass": 39964.0, "monoisotopic_mass": 39964.0 }, "refseq": { "ac": "XP_003587674", "name": "probable G-protein coupled receptor 27", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587674" }, "gene_names": [ { "name": "GPR27", "type": "recommended", "evidence": [ { "id": "A0AAA9SYV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2" } ] }, { "name": "GPR27", "type": "synonym", "evidence": [ { "id": "XP_003587674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587674" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 27", "type": "synonym", "evidence": [ { "id": "A0AAA9SYV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2/entry#names_and_taxonomy" } ] }, { "name": "probable G-protein coupled receptor 27", "type": "synonym", "evidence": [ { "id": "XP_003587674", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587674" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2", "locus": { "chromosome": "22", "start_pos": 29885605, "end_pos": 29889517, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058000", "url": "https://www.ensembl.org/id/ENSBTAG00000058000" } ] } } ], "crossref": [ { "id": "A0AAA9SYV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15216", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15216", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782069", "url": "https://www.ncbi.nlm.nih.gov/gene/782069", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782069", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIFEHRH", "url": "https://omabrowser.org/oma/group/CIFEHRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR19268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19268:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19268:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587674", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587674", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANASEPGSGGGGGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL", "length": 379, "header": "tr|A0AAA9SYV2-1|A0AAA9SYV2_BOVIN Isoform 1 of G protein-coupled receptor 27 OS=Bos taurus OX=9913 GN=GPR27 PE=4 SV=1 CANONICAL=A0AAA9SYV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2/entry#A0AAA9SYV2-1", "sequence": { "sequence": "MANASEPGSGGGGGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL", "length": 379, "header": "tr|A0AAA9SYV2-1|A0AAA9SYV2_BOVIN Isoform 1 of G protein-coupled receptor 27 OS=Bos taurus OX=9913 GN=GPR27 PE=4 SV=1 CANONICAL=A0AAA9SYV2-1" }, "locus": { "chromosome": "22", "start_pos": 29889102, "end_pos": 29887966, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129277.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129277.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089270.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089270.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 255, "start_aa": "Thr", "end_pos": 255, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr255", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:782069", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782069", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AQL1-1", "protein_name": "G protein-coupled receptor 27", "gene_name": "GPR27", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANASEPGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGGGEDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL", "length": 376 }, "evidence": [ { "id": "A0AAA9SYV2", "url": "https://omabrowser.org/oma/group/A0AAA9SYV2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54897-1", "protein_name": "Probable G protein-coupled receptor 27", "gene_name": "Gpr27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANASEPGGGGSGGGAEAAALGLRLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGADDEDAPCALEQRPDGAPGALGFLLLLAAVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL", "length": 379 }, "evidence": [ { "id": "A0AAA9SYV2", "url": "https://omabrowser.org/oma/group/A0AAA9SYV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JJH3-1", "protein_name": "Probable G protein-coupled receptor 27", "gene_name": "Gpr27", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANASEPGGGGGGAEAAALGLRLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGADDEDAPCALEQRPDGAPGALGFLLLLAAVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPQATQATLPCDLKGIGL", "length": 377 }, "evidence": [ { "id": "A0AAA9SYV2", "url": "https://omabrowser.org/oma/group/A0AAA9SYV2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NS67-1", "protein_name": "Probable G protein-coupled receptor 27", "gene_name": "GPR27", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDDEDAPCALEQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPCCQSPRTTQATHPCDLKGIGL", "length": 375 }, "evidence": [ { "id": "A0AAA9SYV2", "url": "https://omabrowser.org/oma/group/A0AAA9SYV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYV2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 342, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 255 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 }, { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYX3-1", "uniprot_ac": "A0AAA9SYX3", "uniprot_id": "A0AAA9SYX3_BOVIN", "mass": { "chemical_mass": 62607.0, "monoisotopic_mass": 62607.0 }, "refseq": { "ac": "XP_002691182", "name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691182" }, "gene_names": [ { "name": "ITPRIPL1", "type": "recommended", "evidence": [ { "id": "A0AAA9SYX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" } ] }, { "name": "ITPRIPL1", "type": "synonym", "evidence": [ { "id": "XP_002691182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691182" } ] } ], "protein_names": [ { "name": "ITPRIP like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SYX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3/entry#names_and_taxonomy" } ] }, { "name": "inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "type": "synonym", "evidence": [ { "id": "XP_002691182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691182" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITPRIPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3", "locus": { "chromosome": "11", "start_pos": 2431976, "end_pos": 2425402, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063199", "url": "https://www.ensembl.org/id/ENSBTAG00000063199" } ] } } ], "crossref": [ { "id": "539436", "url": "https://www.ncbi.nlm.nih.gov/gene/539436", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539436", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539436", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSVHWPE", "url": "https://omabrowser.org/oma/group/TSVHWPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10656:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10656:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691182", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691182", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVISLLFLAVMYVVHHPLLVSDRMDLDTLARSRQLEKRMSEEMRQLELEFEERKRAAEEKQKAENFWRGDTSGDQLVLGKKDRGWPFQVDGQEGPLGWMLGNLWNAGLFCIFLIFELLRQNMQHEPAFDSSSDDDEEEVRVVPITSYNWLTDFPSREALESFHKHHVQNVTRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIIPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDHSALVGKSNSSIKAALCTGSHLDVYKTVQWFRNMVGNAWALVAHKYDFKLSLPLSTTCCKLRLDYRSGRFLSIRLVLGVQREDTLVYLVSQAPDQEQVTSVDWPESFAACEHLFLKLVGRFAPENTCHLKCLQIILSLRDLQSLPQGASRPILTSYHFKTALMHLLLRLPLTDWQHDMLSQRLQDILWFLGRGLQQRSLHHFLIGNTFLPLTIPIPKTFRNAEPVNLFQHLVLNPMAHSQAVEEFHNLLAQVKALPCSSLAGAR", "length": 547, "header": "tr|A0AAA9SYX3-1|A0AAA9SYX3_BOVIN Isoform 1 of ITPRIP like 1 OS=Bos taurus OX=9913 GN=ITPRIPL1 PE=3 SV=1 CANONICAL=A0AAA9SYX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3/entry#A0AAA9SYX3-1", "sequence": { "sequence": "MAVISLLFLAVMYVVHHPLLVSDRMDLDTLARSRQLEKRMSEEMRQLELEFEERKRAAEEKQKAENFWRGDTSGDQLVLGKKDRGWPFQVDGQEGPLGWMLGNLWNAGLFCIFLIFELLRQNMQHEPAFDSSSDDDEEEVRVVPITSYNWLTDFPSREALESFHKHHVQNVTRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIIPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDHSALVGKSNSSIKAALCTGSHLDVYKTVQWFRNMVGNAWALVAHKYDFKLSLPLSTTCCKLRLDYRSGRFLSIRLVLGVQREDTLVYLVSQAPDQEQVTSVDWPESFAACEHLFLKLVGRFAPENTCHLKCLQIILSLRDLQSLPQGASRPILTSYHFKTALMHLLLRLPLTDWQHDMLSQRLQDILWFLGRGLQQRSLHHFLIGNTFLPLTIPIPKTFRNAEPVNLFQHLVLNPMAHSQAVEEFHNLLAQVKALPCSSLAGAR", "length": 547, "header": "tr|A0AAA9SYX3-1|A0AAA9SYX3_BOVIN Isoform 1 of ITPRIP like 1 OS=Bos taurus OX=9913 GN=ITPRIPL1 PE=3 SV=1 CANONICAL=A0AAA9SYX3-1" }, "locus": { "chromosome": "11", "start_pos": 2428622, "end_pos": 2426982, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102162.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102162.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102388.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102388.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539436", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539436", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2ASA8-1", "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "Itpripl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVISLMFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRQLEMEFEERSRAAEQKQKVENFWRGDTSSDQLVLGKKDMGWPFQAGGQDGGPLGWILGNLWNAGLFCLFLIFELLRQSMQHEPAFESSSEEEEEEIRVVPVSSYTRLSDFPSQEALEAFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGFGAAFEKWGTLHETQNFDVLVPIVPPQGTMFILEMRDPALGRRCGCVKVDSECMCKHEKLLGDVLCLVHHRDHSAMLSKCTSSIKAALCTSSHLDVCKTVQWFRNMVSNAWALVAHKYDFKLTFPPSTTSCKLRLGYRSGRSLSISLVLGVQREDTLVYLVSQAPEQEQLTSVDWPESFAACEHLFLKLVGRFAPENTCHLKCLQIVLSLQDHQILPPGASRPILTSYHFKTALMHLLLRLPLTDWQHSMLSLRLQDLLWFLGRGLQQRSLHHFLIGNTYLPLTIPIPKAFRNAEPVNLFQHLVLNPVAHSQAVEEFHNLLAQVKTLPCSPVAGGL", "length": 547 }, "evidence": [ { "id": "A0AAA9SYX3", "url": "https://omabrowser.org/oma/group/A0AAA9SYX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3H038-1", "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "Itpripl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMTEEMRQLELEFEERRRAAEQKQKAENFWRGDTSSDQLVLGKKDMGWPFQASWLMGNLWNAGLFCLFLIFELLRQNMQHEPAFDSSSEEEEEEIRIVPVTSYSYPWLSNFPSQEALESFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPRLEDCLGIGAAFEKWGTLHETHTFDVLVPIVPPQGTMFVLEMRDPALGRRSGCVKVDSKCMCKQEKLLGDVLCLVHHDRDHSAILSKCTGSIKAALCTGSHLDVCKAVQWFRNMVANAWALVAHKYNFKLTLPPSSTSCKLRLDYRSGRFLSISLVLGVQREDTLVYLVSQDPDREQLTSVDWPESFAACEHLFLKLVGRFAPENTCHLKCLQIILSLQDHQILPPGATRPILNTYHFKTALMHLLLRLPLTDWEHCMLSRRLQDLLWFLGQGLQQRSLHHFLIGNTFLPLTIPIPKTFRNAEPVNLFQHLVLNPIAHSQAMEEFHNLLAQVKTLPCSPLAGGL", "length": 542 }, "evidence": [ { "id": "A0AAA9SYX3", "url": "https://omabrowser.org/oma/group/A0AAA9SYX3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q66H52-1", "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "Itpripl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRQLEIEFEERSRAAEEKQKAENFWRGDTSNDQLVLGKKDMRWPFQASGQDGGPLGWMLGNLWNAGLFCLFLIFELLRQNMQHEPAFESSSEEEEEEIRVVPVSSYTWLSGFPSQEALESFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGIGAAFEKWGTLHETQKFDVLVPIVPPQGTMFILEMRDPTLGRRCGCVKVDSECVCKNEKLLGDVLCLVHHRDHSAMLSKCTSSIKAALCTSSHLDVYKTVQWFRNMVSNAWALVAHKYDFKLTLPPSTTTCKLRLDYRSGRSLSISLVLGVQREDTLVYLVSQAPEREQFTSVDWPESFAACEHLFLKLVGRFAPDNTCHLKCLQIILSLQDHQTLPPGASRPILTSYHFKTALMHLLLRLPLTDWQHRMLSQRLQDLLWFLGRSLQQRSLHHFLIGNTHLPLTIPIPKAFRNAEPVNLFQHLVLNPVAHSQAVEEFHNLLAQVKTLPCSPLAGGL", "length": 547 }, "evidence": [ { "id": "A0AAA9SYX3", "url": "https://omabrowser.org/oma/group/A0AAA9SYX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6GPH6-1", "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1", "gene_name": "ITPRIPL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFEERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCLFLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAIRDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVPIVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCSSSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGRFLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHLKCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWFLGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQNLLTQVKTLPHAPLAAAP", "length": 555 }, "evidence": [ { "id": "A0AAA9SYX3", "url": "https://omabrowser.org/oma/group/A0AAA9SYX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of T cell receptor signaling pathway", "id": "GO:0050860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050860", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX3" }, { "id": "PF20266", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20266" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mab-21-like HhH/H2TH-like", "eco_id": "ECO_0000259", "start_pos": 410, "end_pos": 487, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 292, "end_pos": 294 } ] }, "class_list": [], "section_stats": [ { 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYZ4-1", "uniprot_ac": "A0AAA9SYZ4", "uniprot_id": "A0AAA9SYZ4_BOVIN", "mass": { "chemical_mass": 35536.0, "monoisotopic_mass": 35536.0 }, "refseq": { "ac": "NP_001377344", "name": "olfactory receptor family 4 subfamily F member 14H", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344" }, "gene_names": [ { "name": "OR4F14H", "type": "recommended", "evidence": [ { "id": "A0AAA9SYZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4" } ] }, { "name": "OR4F14H", "type": "synonym", "evidence": [ { "id": "NP_001377344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9SYZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4F3/4F16/4F29", "type": "synonym", "evidence": [ { "id": "NP_001377344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344" } ] }, { "name": "olfactory receptor family 4 subfamily F member 14H", "type": "synonym", "evidence": [ { "id": "NP_001377344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4F14H", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4", "locus": { "chromosome": "10", "start_pos": 28014608, "end_pos": 28013655, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066823", "url": "https://www.ensembl.org/id/ENSBTAG00000066823" } ] } } ], "crossref": [ { "id": "A0AAA9SYZ4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785082", "url": "https://www.ncbi.nlm.nih.gov/gene/785082", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785082", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785082", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377344", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLTKSMEGANQSVVSEFLFLGLTNSWEIQLLLFVFSSTFYVASMMGNSLIILTVTCDPHLHSPMYFLLANLSLIDLGVSSVTSPKMIYDLFRKHKVISFGGCIAQIFFIHVIGGVEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCVFFIVAAWMIGLTHSMVQLAFVVKLPFCGPNVLDTFYCDLPRFIKLACIDTYQLKSMITANSGFISVGSFFILIISYIIIILTLQKQSSAGSSKALSTLSAHITVVVLFFGPLVFVYTWPSPSIPLDKFLAIFDAVLTPLLNPVIYTFRNQEMKVAMRRVCRQLVSYRKIS", "length": 317, "header": "tr|A0AAA9SYZ4-1|A0AAA9SYZ4_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4F14H PE=3 SV=1 CANONICAL=A0AAA9SYZ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYZ4/entry#A0AAA9SYZ4-1", "sequence": { "sequence": 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It catalyzes the transport of pyruvate across the plasma membrane. 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"https://www.uniprot.org/uniprotkb/G3MZ44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPKPTGPPDGGWGWVVAAAGFAVNGLSYGVLRSLGLAFPDFAEYFDRNAQETAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGFVFSAFAHSLLHLYLGLGVLAGSGWALVFAPALGTVSRYFSRRRVLAVGLALMGNGASSLLLAPALQLLLDNFGWRGALLLLGAVTLHLTPCGALLRPLALPGDPLALPRSPLAALGLGLFRRPAFLVLTLGTALVGVGYFIPYVHLAPHALDRGLGGYGAALVVAAAAVGDIGARLPCGWLADQGWVPLPRLLTIFGALTGLGLLAVGLVPVVGNEDSWGGPLLAAAGVYGLSAGSFAPLTFCVLPELVGIGNVVQATGLVMLLLSLGGLLGPPLSGFLKDETGDFTASFLMCGSFVLSGSFIYLGLPKALPSCRQASRPGTPPPEMGELLPVPQVALLSPGDPHSTLDTTC", "length": 447, "header": "tr|A0AAA9SZ02-1|A0AAA9SZ02_BOVIN Isoform 1 of Monocarboxylate transporter 11 OS=Bos taurus OX=9913 GN=SLC16A11 PE=3 SV=1 CANONICAL=A0AAA9SZ02-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ02/entry#A0AAA9SZ02-1", "sequence": { "sequence": 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"G3MZ44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ02/entry#G3MZ44-1", "sequence": { "sequence": "MTPKPTGPPDGGWGWVVAAAGFAVNGLSYGVLRSLGLAFPDFAEYFDRNAQETAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGFVFSAFAHSLLHLYLGLGVLAGSGWALVFAPALGTVSRYFSRRRVLAVGLALMGNGASSLLLAPALQLLLDNFGWRGALLLLGAVTLHLTPCGALLRPLALPGDPLALPRSPLAALGLGLFRRPAFLVLTLGTALVGVGYFIPYVHLAPHALDRGLGGYGAALVVAAAAVGDIGARLPCGWLADQGWVPLPRLLTIFGALTGLGLLAVGLVPVVGNEDSWGGPLLAAAGVYGLSAGSFAPLTFCVLPELVGIGNVVQATGLVMLLLSLGGLLGPPLSGFLKDETGDFTASFLMCGSFVLSGSFIYLGLPKASRPGTPPPEMGELLPVPQVALLSPGDPHSTLDTTC", "length": 440, "header": "tr|G3MZ44-1|G3MZ44_BOVIN Computationally mapped isoform of Monocarboxylate transporter 11 OS=Bos taurus OX=9913 GN=SLC16A11 PE=3 SV=3 CANONICAL=A0AAA9SZ02-1" }, "locus": { "chromosome": "19", "start_pos": 26827639, "end_pos": 26825725, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065352.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065352.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054836.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054836.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618274", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618274", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5NC32-1", "protein_name": "Monocarboxylate transporter 11", "gene_name": "Slc16a11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTPKPAGPPDGGWGWVVAAAAFAVNGLSYGLLRSLGLALPDLAEHFERSAQDTAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGLVFSAFARSLLHLYLGLGLLAGSGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQFLLDTFGWRGALLLLGAVTLHLTPCGALLRPLALSGDPLAPPRTPLAALGLGLFKRRAFSVFALGTALIGGGYFVPYVHLGPHALDQGMGGYGAALVVAVAAVGDACARLASGWLADQGWVPLPRLLVVFGSLTGLGVLAMGLVPTVGTEEGWGAPLLAAAGAYGLSAGSYAPLVFGVLPGLVGIGGVVQATGLVMMLMSLGGLLGPPLSGFLRDKTGDFSASFLVCSSFILSGSFIYMGLPRALPSCRPASPPATPPPERGELLPVPQVSLLSAGGTGSIRDTTC", 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"url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDKN2AIPNL", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07", "locus": { "chromosome": "7", "start_pos": 45942492, "end_pos": 45972754, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010984", "url": "https://www.ensembl.org/id/ENSBTAG00000010984" } ] } } ], "crossref": [ { "id": "A0AAA9SZ07", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZ07", "database": "AlphaFoldDB", "categories": [] }, { "id": "512206", "url": "https://www.ncbi.nlm.nih.gov/gene/512206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR021859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PF11952", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11952", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SZ07", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3W7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVT2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPPRPPRALQTNPPAQSRAAGAPLAAERWRSACREGSGRVRPLAVEGAMVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKIFSSFSITSGYAFCCCCC", "length": 180, "header": "tr|A0AAA9SZ07-1|A0AAA9SZ07_BOVIN Isoform 1 of CDKN2A interacting protein N-terminal like OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=A0AAA9SZ07-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07/entry#A0AAA9SZ07-1", "sequence": { "sequence": "MRPPRPPRALQTNPPAQSRAAGAPLAAERWRSACREGSGRVRPLAVEGAMVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKIFSSFSITSGYAFCCCCC", "length": 180, "header": "tr|A0AAA9SZ07-1|A0AAA9SZ07_BOVIN Isoform 1 of CDKN2A interacting protein N-terminal like OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=A0AAA9SZ07-1" }, "locus": { "chromosome": "7", "start_pos": 45972555, "end_pos": 45956525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109006.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109006.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089518.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089518.1" } ] } }, { "isoform_ac": "A0AAA9T3W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07/entry#A0AAA9T3W7-1", "sequence": { "sequence": "MRPPRPPRALQTNPPAQSRAAGAPLAAERWRSACREGSGRVRPLAVEGAMVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKK", "length": 163, "header": "tr|A0AAA9T3W7-1|A0AAA9T3W7_BOVIN Computationally mapped isoform of CDKN2A interacting protein N-terminal like OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=A0AAA9SZ07-1" }, "locus": { "chromosome": "7", "start_pos": 45972555, "end_pos": 45967575, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101470.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101470.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090392.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090392.1" } ] } }, { "isoform_ac": "A0AAF6YVT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ07/entry#A0AAF6YVT2-1", "sequence": { "sequence": "MVGGEAAAAVEELISGVRRATDFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGGGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKENESHNENSTAWALPVIFLLFIGGCHSIRT", "length": 143, "header": "tr|A0AAF6YVT2-1|A0AAF6YVT2_BOVIN Computationally mapped isoform of CDKN2A interacting protein N-terminal like OS=Bos taurus OX=9913 GN=CDKN2AIPNL PE=3 SV=1 CANONICAL=A0AAA9SZ07-1" }, "locus": { "chromosome": "7", "start_pos": 45972408, "end_pos": 45942494, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014579.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014579.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014579.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014579.5" } ] } } ], "glycosylation": [], 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{ "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZ40-1", "uniprot_ac": "A0AAA9SZ40", "uniprot_id": "A0AAA9SZ40_BOVIN", "mass": { "chemical_mass": 110510.0, "monoisotopic_mass": 110510.0 }, "refseq": {}, "gene_names": [ { "name": "ELAPOR1", "type": "recommended", "evidence": [ { "id": "A0AAA9SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40" } ] }, { "name": "KIAA1324", "type": "synonym", "evidence": [ { "id": "A0AAA9SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40" } ] } ], "protein_names": [ { "name": "Endosome-lysosome associated apoptosis and autophagy regulator 1", "type": "synonym", "evidence": [ { "id": "A0AAA9SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], 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"https://www.ebi.ac.uk/interpro/entry/IPR009011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22727", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22727", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22727:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22727:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07699", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07699", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23031", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23031", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23032", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23032", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23091", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23091", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SZ40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIM6", "url": "https://www.uniprot.org/uniprotkb/F1MIM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIM6-1", "url": "https://www.uniprot.org/uniprotkb/F1MIM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEPGHSLHPSARGRGRTEPRTFRLLRLLLWVGTAFQVTQGAGLELHACKESEYHYEYTACDSTGSRWRVAVPHTPGLCTSLPDPVKGTECSFSCKAGEFLDMKDQSCKPCAEGRYSLGTGIRFDEWDELPHGFASLSTNMEIEDSTLESTENCTSSKWVPLGDYIASNTDECTATLMYAVNLKQSGTVNFEYYYPDSSIIFEFFVQNDQCQPNADDSRWMKTTEKGWEFHSVELNRGNNVLYWRTTAFSVWSKVSKPVLVRNIAITGVAYTSECFPCKPGTYADQQGSSSCKLCPANFYSNKGETSCHQCDPDKYSEKGSSTCKARPACTDKDYFYTHTACDANGETQLMYKWAQPKICSEDLEGAVKLPASGLKTGCPPCNPGFFKTNSSTCEPCPYGSYSNGSGTEPAVGFEYKWWNTLPTNMETTVLSGINFEYRGMTGWEVAGDHIYSAVGASDNDFMILTLVVPGFRPPQSVMADTENKEVARITFVFETICSVNCELYFMVGVNSRTNSPVETWKGSKGKQSYTYIIEENATMSFTWAFQRTTFHETGRKYTSDVAKIYSINVTNVMDGVASYCRPCALEASDMGSSCTSCLAGHYIDRDSGTCHSCPPNTILKAHQPYGAQACMPCGPGTKSNKIHSLCYNDCTFSVSTSTRTFEYNFLALEKTVSLAGGPSFTSKGLKYFHHFTLSLCGNQGRKMSVCTDNVTDLRIPEGESGFSKPITAYVCQAIIIPPEVTGYKAGVSSQPVSLADRLIGVTTDMTLDGITSPAELFHPESLGIPDVIFFYRSNDVTQSCSSGRSTTIRVRCSPLKPAPGSLSLPSKCSDGTCDGCNFHFLWESVAACPLCSTADYHAIVSSCVAGIQKTTYVWREPKLCSGGISLPEQRVTICKTIDFWLKVGISAGTCTAILLTVLTCYFWKKNQKLEYKYSKLVMNATLKDCDLPAADSCAIMEGEDVEDDLIFTSKKSLFGKIKSFTSKRTPDGFDSVPLKTSSGGPDMDL", "length": 1006, "header": "tr|A0AAA9SZ40-1|A0AAA9SZ40_BOVIN Isoform 1 of Endosome-lysosome associated apoptosis and autophagy regulator 1 OS=Bos taurus OX=9913 GN=ELAPOR1 PE=3 SV=1 CANONICAL=A0AAA9SZ40-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40/entry#A0AAA9SZ40-1", "sequence": { "sequence": 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"length": 1006, "header": "tr|A0AAA9SZ40-1|A0AAA9SZ40_BOVIN Isoform 1 of Endosome-lysosome associated apoptosis and autophagy regulator 1 OS=Bos taurus OX=9913 GN=ELAPOR1 PE=3 SV=1 CANONICAL=A0AAA9SZ40-1" }, "locus": { "chromosome": "3", "start_pos": 34273992, "end_pos": 34200680, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128486.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128486.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090661.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090661.1" } ] } }, { "isoform_ac": "F1MIM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ40/entry#F1MIM6-1", "sequence": { "sequence": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZ65-1", "uniprot_ac": "A0AAA9SZ65", "uniprot_id": "A0AAA9SZ65_BOVIN", "mass": { "chemical_mass": 20957.0, "monoisotopic_mass": 20957.0 }, "refseq": { "ac": "XP_005214400", "name": "serine hydrolase RBBP9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214400" }, "gene_names": [ { "name": "RBBP9", "type": "recommended", "evidence": [ { "id": "A0AAA9SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ] }, { "name": "RBBP9", "type": "synonym", "evidence": [ { "id": "XP_005214400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214400" } ] } ], "protein_names": [ { "name": "Serine hydrolase RBBP9", "type": "recommended", "evidence": [ { "id": "A0AAA9SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65/entry#names_and_taxonomy" } ] }, { "name": "B5T-overexpressed gene protein", "type": "synonym", "evidence": [ { "id": "A0AAA9SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65/entry#names_and_taxonomy" } ] }, { "name": "Retinoblastoma-binding protein 9", "type": "synonym", "evidence": [ { "id": "A0AAA9SZ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65/entry#names_and_taxonomy" } ] }, { "name": "serine hydrolase RBBP9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214400", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214400" } ] } ], "function": [ { "annotation": "Serine hydrolase. Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65#function" }, { "database": "UniProtKB", "id": "ARBA00093284", "url": "https://www.uniprot.org/uniprotkb/ARBA00093284#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBBP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65", "locus": { "chromosome": "13", "start_pos": 38547012, "end_pos": 38554868, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008826", "url": "https://www.ensembl.org/id/ENSBTAG00000008826" } ] } } ], "crossref": [ { "id": "A0AAA9SZ65", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZ65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008826", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008826", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513835", "url": "https://www.ncbi.nlm.nih.gov/gene/513835", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NRPWEWE", "url": "https://omabrowser.org/oma/group/NRPWEWE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MS64", "url": "https://www.orthodb.org/?gene=F1MS64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15394:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15394:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06821", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06821", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214400", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214400", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "83871", "url": "https://www.rhea-db.org/rhea/83871", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS64", "url": "https://www.uniprot.org/uniprotkb/F1MS64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS64-1", "url": "https://www.uniprot.org/uniprotkb/F1MS64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPCKAVIIPGNGGEDVATHGWYGWVKRELEQIPGFQCLSKNMPDPITARESIWLPFMEMELHCDEETIIIGHSSGAIAAMRYAETHRVYAIVLVAAYTSDLGDANERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQQEVADRLEAKLYKFTDRGHFQNTEFHELVSAVGSMLKVPA", "length": 186, "header": "tr|A0AAA9SZ65-1|A0AAA9SZ65_BOVIN Isoform 1 of Serine hydrolase RBBP9 OS=Bos taurus OX=9913 GN=RBBP9 PE=3 SV=1 CANONICAL=A0AAA9SZ65-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65/entry#A0AAA9SZ65-1", "sequence": { "sequence": "MAAPCKAVIIPGNGGEDVATHGWYGWVKRELEQIPGFQCLSKNMPDPITARESIWLPFMEMELHCDEETIIIGHSSGAIAAMRYAETHRVYAIVLVAAYTSDLGDANERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQQEVADRLEAKLYKFTDRGHFQNTEFHELVSAVGSMLKVPA", "length": 186, "header": "tr|A0AAA9SZ65-1|A0AAA9SZ65_BOVIN Isoform 1 of Serine hydrolase RBBP9 OS=Bos taurus OX=9913 GN=RBBP9 PE=3 SV=1 CANONICAL=A0AAA9SZ65-1" }, "locus": { "chromosome": "13", "start_pos": 38554857, "end_pos": 38549985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125779.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125779.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090707.1" } ] } }, { "isoform_ac": "F1MS64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65/entry#F1MS64-1", "sequence": { "sequence": "MAAPCKAVIIPGNGGEDVATHGWYGWVKRELEQIPGFQCLSKNMPDPITARESIWLPFMEMELHCDEETIIIGHSSGAIAAMRYAETHRVYAIVLVAAYTSDLGDANERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQQEVADRLEAKLYKFTDRGHFQNTEFHEL", "length": 174, "header": "tr|F1MS64-1|A0AAA9SZ65_BOVIN Computationally mapped isoform of Serine hydrolase RBBP9 OS=Bos taurus OX=9913 GN=RBBP9 PE=3 SV=1 CANONICAL=A0AAA9SZ65-1" }, "locus": { "chromosome": "13", "start_pos": 38554857, "end_pos": 38550021, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046618.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046618.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043899.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043899.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SBH3-1", "protein_name": "Serine hydrolase RBBP9", "gene_name": "RBBP9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASPSKAVIVPGNGGGDVATHGWYGWVKKRLEQIPGFQCLAKNMPDPITARESIWLPFMETELRCDEETIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQQEVADRLEAKLYSFTDRGHFQNTEFHELVNVVKSLLKVQA", "length": 186 }, "evidence": [ { "id": "A0AAA9SZ65", "url": "https://omabrowser.org/oma/group/A0AAA9SZ65/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GVW2-1", "protein_name": "Serine hydrolase RBBP9", "gene_name": "Rbbp9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAFPVKAVIVPGNGGGDVATQGWYGWVRKRLEQIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHQVYGLVLVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQAEVADRLNAKLYKFDNRGHFQNTEFHELISVVKSMLKVPE", "length": 186 }, "evidence": [ { "id": "A0AAA9SZ65", "url": "https://omabrowser.org/oma/group/A0AAA9SZ65/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75884-1", "protein_name": "Serine hydrolase RBBP9", "gene_name": "RBBP9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA", "length": 186 }, "evidence": [ { "id": "A0AAA9SZ65", "url": "https://omabrowser.org/oma/group/A0AAA9SZ65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88350-1", "protein_name": "Serine hydrolase RBBP9", "gene_name": "Rbbp9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPTKAVIVPGNGGGDVATHGWYGWVRKGLEQIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHQVYALILVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIIQFGSTDDPFLPWKEQQEVADRLDAKLYKFTDRGHFQNTEFHELIRVVKSMLTPAL", "length": 186 }, "evidence": [ { "id": "A0AAA9SZ65", "url": "https://omabrowser.org/oma/group/A0AAA9SZ65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O88851-1", "protein_name": "Serine hydrolase RBBP9", "gene_name": "Rbbp9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASPNKAVIVPGNGGGDVATHGWYGWVKKGLEQIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHQVYALVLVSAYTSDLGDENERASGYFSRPWQWEKIKANCPHIVQFGSTDDPFLPWKEQQEVADRLDAKLYKFTDRGHFQNTEFHELISVVKSMLKGPE", "length": 186 }, "evidence": [ { "id": "A0AAA9SZ65", "url": "https://omabrowser.org/oma/group/A0AAA9SZ65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine hydrolase activity", "id": "GO:0017171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017171", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "83871", "name": "", "equation": "valacyclovir + H2O = acyclovir + L-valine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "83871", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83871" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"gene_names": [], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SZ77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ77/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZ77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ77", "locus": {} } ], "crossref": [ { "id": "A0AAA9SZ77", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZ77", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein 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CANONICAL=A0AAA9SZB6-1" }, "locus": { "chromosome": "13", "start_pos": 64010742, "end_pos": 63921172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088817.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088817.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088710.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088710.1" } ] } }, { "isoform_ac": "F1N7F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6/entry#F1N7F8-1", "sequence": { "sequence": "MAAPLALVLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRGLSLLDLGVSPYSGAVFHETPLIIYLFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVAMFYLLNPYTVLSCVAKSTCAINNTLIAFFILATMKGSALLSAIFLALATYQSLYPLTLFVPGLLYLLQRQYIPVKVKSKAFWIFFWEYAMMYMGSLVVVVCLSFFLLSSWDFIPAVYGFILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKDHPIFFMFIQIAIIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLACIIIICSLLFPVLWHLWIYAGSANSNFFYAITLTFNIGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK", "length": 432, "header": "tr|F1N7F8-1|F1N7F8_BOVIN Computationally mapped isoform of Phosphatidylinositol glycan anchor biosynthesis class U OS=Bos taurus OX=9913 GN=PIGU PE=3 SV=3 CANONICAL=A0AAA9SZB6-1" }, "locus": { "chromosome": "13", "start_pos": 64011546, "end_pos": 63921172, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015432.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015432.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015432.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015432.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-162791", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162791", "resource": "Reactome", "description": "Attachment of GPI anchor to uPAR" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GPI anchor binding", "id": "GO:0034235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" }, { "name": "GPI-anchor transamidase activity", "id": "GO:0003923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" }, { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" }, { "name": "attachment of GPI anchor to protein", "id": "GO:0016255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" }, { "name": "GPI-anchor transamidase complex", "id": "GO:0042765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZD2-1", "uniprot_ac": "A0AAA9SZD2", "uniprot_id": "A0AAA9SZD2_BOVIN", "mass": { "chemical_mass": 20203.0, "monoisotopic_mass": 20203.0 }, "refseq": {}, "gene_names": [ { "name": "C9H6orf120", "type": "recommended", "evidence": [ { "id": "A0AAA9SZD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2" } ] } ], "protein_names": [ { "name": "Chromosome 9 C6orf120 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9SZD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2#function" }, { "database": "UniProtKB", "id": "ARBA00003276", "url": "https://www.uniprot.org/uniprotkb/ARBA00003276#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C9H6orf120", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2", "locus": {} } ], "crossref": [ { "id": "A0AAA9SZD2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SZD2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR031420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FGETAYS", "url": "https://omabrowser.org/oma/group/FGETAYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31703", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31703", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31703:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31703:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17065", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17065", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SZD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPWTGALLLLLASQAVSSAQALDEEEVPEGWVLLHVVQGQVGAGNYSYLRLNHEGKIVLRMRSLRGDADLYVSDSTLHPSFDEYELQSATCGADAVSIPAHFRRPVGIGVYGHPSHLESAFEMKVYYDATLEPHPFGETAYSDGTDASRKHAYAPEDASQEEESVLWTILISILKLVLEILF", "length": 184, "header": "tr|A0AAA9SZD2-1|A0AAA9SZD2_BOVIN Isoform 1 of Chromosome 9 C6orf120 homolog OS=Bos taurus OX=9913 GN=C9H6orf120 PE=3 SV=1 CANONICAL=A0AAA9SZD2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2/entry#A0AAA9SZD2-1", "sequence": { "sequence": "MAAPWTGALLLLLASQAVSSAQALDEEEVPEGWVLLHVVQGQVGAGNYSYLRLNHEGKIVLRMRSLRGDADLYVSDSTLHPSFDEYELQSATCGADAVSIPAHFRRPVGIGVYGHPSHLESAFEMKVYYDATLEPHPFGETAYSDGTDASRKHAYAPEDASQEEESVLWTILISILKLVLEILF", "length": 184, "header": "tr|A0AAA9SZD2-1|A0AAA9SZD2_BOVIN Isoform 1 of Chromosome 9 C6orf120 homolog OS=Bos taurus OX=9913 GN=C9H6orf120 PE=3 SV=1 CANONICAL=A0AAA9SZD2-1" }, "locus": { "chromosome": "9", "start_pos": 103493677, "end_pos": 103493126, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088727.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1NYK5-1", "protein_name": "C6orf120 homolog", "gene_name": "C6orf120", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAARWRRILIVFVAAQVLCLVNTFEEEDVPEEWILLHVVQGQIGAGNYSYLRLNHEGKIVLQMQSLKGDADLYVSDMTLHPSFDEYELQSVTCGQDIVHVPAHFRRPVGIGIYGHPSHQESEFEMKVYYDRTVVQYPFGEASYNPEEMEANQKYSHSTEDESQDEESVFWTILIGILKLILEILF", "length": 185 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HK34-1", "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "C2H6orf120", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPWRCALWVLLASRVLTLVEGLEEDDVPHEWLLLHVVQGQIGAGNYSYLRLNHEGKIILRMQSLRGDADLYVSDSTLHPSFDEYELQSATCGQDVVSIPAHFQRPVGIGIYGHPSHHESDFEMRVYSDRTVDQYPFGEAAYPADPTGASQNQAYAPEEAAQEEESVLWTILISILKLVLEILF", "length": 185 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LL77-1", "protein_name": "Chromosome 1 C6orf120 homolog", "gene_name": "C6orf120", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPWKSALLLLLASQAASWVGAFDADEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLKMQSLKGDADLYVSDTTLHPSFDDYELQSVTCGQDVVFIPAHFQRPVGIGIYGHPSHHESEFEMKVYYDATIEQHPFGETAFSDGTDVSRKHAYSPEDASQEDESVLWTILISILKLVLEILF", "length": 184 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AY64-1", "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATPWRCALLMILASQVVILVKCLEDDDVPEEWLLLHVVQGQIGAGNYSYLRLNHEGKIILRMQSLRGDADLYVSDSTPHPSFDEYELQSVTCGQDVVSIPAHFQRPVGIGIYGHPSHHESDFEMRVYYDRTVDQYPFGEAAYAADQTGTSQKQAYTPEEAAQEEESVLWTILISILKLVLEILF", "length": 185 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NZZ3-1", "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVPFWAGLLVLSALPQTLGFLQHSEEPYVPGEWVLLHVVQGHIGAGNYSYLRLNHEGRIILHMQSLKGDADLYVSDKTLRPNFDTYKLQSTTCGPDVVVVPGDFLRPVGIGIYGHPSYMESEFEMKVFYDQKALAEIEIEKNSYSSDETPGQPRQSQGPEDTEEEEESILWTILIGILKIILEILF", "length": 186 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7Z4R8-1", "protein_name": "UPF0669 protein C6orf120", "gene_name": "C6orf120", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPRGRAAPWTTALLLLLASQVLSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHAGAPEDASQEEESVLWTILISILKLVLEILF", "length": 191 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAY5-1", "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATPWRRALLMILASQVVTLVKCLEDDDVPEEWLLLHVVQGQIGAGNYSYLRLNHEGKIILRMQSLRGDADLYVSDSTPHPSFDDYELQSVTCGQDVVSIPAHFQRPVGIGIYGHPSHHESDFEMRVYYDRTVDQYPFGEAAYFTDPTGASQQQAYAPEEAAQEEESVLWTILISILKLVLEILF", "length": 185 }, "evidence": [ { "id": "A0AAA9SZD2", "url": "https://omabrowser.org/oma/group/A0AAA9SZD2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 47, "end_pos": 49 } ] }, "class_list": [], "section_stats": [ { "table_id": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377644" }, "gene_names": [ { "name": "OR7A99", "type": "recommended", "evidence": [ { "id": "A0AAA9T0J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J9" } ] }, { "name": "OR7A99", "type": "synonym", "evidence": [ { "id": "NP_001377644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377644" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 7 subfamily A member 99", "type": "synonym", "evidence": [ { "id": "A0AAA9T0J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 7 subfamily A member 99", "type": "synonym", "evidence": [ { "id": "NP_001377644", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377644" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377644" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7A99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J9", "locus": { "chromosome": "7", "start_pos": 9614292, "end_pos": 9613342, "strand": 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"MYQAMAFLAMVMGTHTLCLGSQRCCTHWPSCCPSKGQNSTEEWLKWNSVLMPPPETTSLAHHPEPCSSSRDGPLNSRSIAPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPLGNSELLYHNQTVFYRRPCPGQQGDHHGYCLERRLYRVSLACVCVRPRVMA", "length": 169, "header": "tr|A0AAA9T0S0-1|A0AAA9T0S0_BOVIN Isoform 1 of Interleukin 25 OS=Bos taurus OX=9913 GN=IL25 PE=3 SV=1 CANONICAL=A0AAA9T0S0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S0/entry#A0AAA9T0S0-1", "sequence": { "sequence": "MYQAMAFLAMVMGTHTLCLGSQRCCTHWPSCCPSKGQNSTEEWLKWNSVLMPPPETTSLAHHPEPCSSSRDGPLNSRSIAPWRYELDRDLNRLPQDLYHARCLCPHCVSLQTGSHMDPLGNSELLYHNQTVFYRRPCPGQQGDHHGYCLERRLYRVSLACVCVRPRVMA", "length": 169, "header": "tr|A0AAA9T0S0-1|A0AAA9T0S0_BOVIN Isoform 1 of Interleukin 25 OS=Bos taurus OX=9913 GN=IL25 PE=3 SV=1 CANONICAL=A0AAA9T0S0-1" }, "locus": { "chromosome": "10", "start_pos": 21550962, "end_pos": 21548276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125187.1", "url": 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"n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0S8-1", "uniprot_ac": "A0AAA9T0S8", "uniprot_id": "A0AAA9T0S8_BOVIN", "mass": { "chemical_mass": 26907.0, "monoisotopic_mass": 26907.0 }, "refseq": {}, "gene_names": [ { "name": "TSPAN8", "type": "recommended", "evidence": [ { "id": "A0AAA9T0S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8" } ] } ], "protein_names": [ { "name": "Tetraspanin", "type": "recommended", "evidence": [ { "id": "A0AAA9T0S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPAN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8", "locus": { "chromosome": "5", "start_pos": 809196, "end_pos": 875163, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019425", "url": "https://www.ensembl.org/id/ENSBTAG00000019425" } ] } } ], "crossref": [ { "id": "A0AAA9T0S8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0S8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019425", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019425", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IAIWIRV", "url": "https://omabrowser.org/oma/group/IAIWIRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MP86", "url": "https://www.orthodb.org/?gene=F1MP86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19282:SF380", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19282:SF380", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T0S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP86", "url": "https://www.uniprot.org/uniprotkb/F1MP86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP86-1", "url": "https://www.uniprot.org/uniprotkb/F1MP86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVIALAFGLAAIEVQYYLKFLRKLCLRCLHLLSSI", "length": 243, "header": "tr|A0AAA9T0S8-1|A0AAA9T0S8_BOVIN Isoform 1 of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN8 PE=3 SV=1 CANONICAL=A0AAA9T0S8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0S8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8/entry#A0AAA9T0S8-1", "sequence": { "sequence": "MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVIALAFGLAAIEVQYYLKFLRKLCLRCLHLLSSI", "length": 243, "header": "tr|A0AAA9T0S8-1|A0AAA9T0S8_BOVIN Isoform 1 of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN8 PE=3 SV=1 CANONICAL=A0AAA9T0S8-1" }, "locus": { "chromosome": "5", "start_pos": 843739, "end_pos": 812009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092529.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092529.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091291.1" } ] } }, { "isoform_ac": "F1MP86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8/entry#F1MP86-1", "sequence": { "sequence": "MAGVNVCIKCSMFIFNFVFWLCGAIILSVAISIRAGKIGQEILAPGDADLNLFIAVNILIFVGAVIMILGFLGCCGAMKENQFMMILFFVGLLMILLLQVAAGIVATTRKSKTEQALNKTLLINARLLSSTDENERVFQKAFSELQEELKCCGLVNGASDWGSNFQHYYRTCECPSESDSSCTKYSGKTIYKQSCFASISQMFSKRLFIVIALAFGLAAIEVLGLIFSIVLYCQMRKK", "length": 238, "header": "tr|F1MP86-1|A0AAA9T0S8_BOVIN Computationally mapped isoform of Tetraspanin OS=Bos taurus OX=9913 GN=TSPAN8 PE=3 SV=1 CANONICAL=A0AAA9T0S8-1" }, "locus": { "chromosome": "5", "start_pos": 843739, "end_pos": 809324, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025875.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025875.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025875.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025875.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "E1C3Y3-1", "protein_name": "Tetraspanin", "gene_name": "TSPAN8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGVSRCLKYSMFIFNFLFWVCGCIILGVSIWIRVNKDAQEALNINNSNMFVGADVLIAVGSIIMILGFLGCCGAIKESRCMLLLFFIGLLLILILQVTGGILGAVYKPQLEEGFNLVITEAANLLKENTENAKQVQESLQKFQLQGHCCGIVDGITDWGNNYNLVIDGKAVCECERKYQEENLCTYFQGRYVFKEPCKTVILNFLQTNMDIIMGIAFGMAVIEVLGLVFSMCLYCQIQRK", "length": 241 }, "evidence": [ { "id": "A0AAA9T0S8", "url": "https://omabrowser.org/oma/group/A0AAA9T0S8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O55158-1", "protein_name": "Tetraspanin", "gene_name": "Tspan8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGVSGCLKYSMFFFNFLFWVCGTLILGLAIWLRVSKDGKEIITSGDNGTNPFIAVNILIAVGSIIMVLGFLGCCGAVKESRCMLLLFFIGLLLILLLQVAAGILGATFKSESSRILNETLYENAKLLSETSNEAKEVQKAMIAFQSEFKCCGLRFGAADWGKNFPDAKESCQCTGSDCESYNGENVYRTTCLSLIKELVEKNIIIVIGIAFGLAVIEILGLVFSMVLYCQIGSK", "length": 235 }, "evidence": [ { "id": "A0AAA9T0S8", "url": "https://omabrowser.org/oma/group/A0AAA9T0S8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P19075-1", "protein_name": "Tetraspanin-8", "gene_name": "TSPAN8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAIIMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGNK", "length": 237 }, "evidence": [ { "id": "A0AAA9T0S8", "url": "https://omabrowser.org/oma/group/A0AAA9T0S8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R3G9-1", "protein_name": "Tetraspanin-8", "gene_name": "Tspan8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGVSSCLKYSMFFFNFLFWVCGTLILGLAIWVRVSKDGKEIITSGDSSTNPFIAVNILIAVGSIIMVLGFLGCCGAVKESRCMLLLFFIGLLLILILQVAAGILGAAFKPEYNRILNETLYENAKLLSDNTDEAKDFQKAMIVFQSEFKCCGLENGAADWGNNFVEAKESCQCTGTDCATYQGSSVYPKTCLSLIKDLFEKNIIIVIGIAFGLAVIEILGLVFSMVLYCQIGSK", "length": 235 }, "evidence": [ { "id": "A0AAA9T0S8", "url": "https://omabrowser.org/oma/group/A0AAA9T0S8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0S8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SZB7-1", "uniprot_ac": "A0AAA9SZB7", "uniprot_id": "A0AAA9SZB7_BOVIN", "mass": { "chemical_mass": 144601.0, "monoisotopic_mass": 144601.0 }, "refseq": { "ac": "XP_059737317", "name": "YEATS domain-containing protein 2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737317" }, "gene_names": [ { "name": "YEATS2", "type": "recommended", "evidence": [ { "id": "A0AAA9SZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ] }, { "name": "YEATS2", "type": "synonym", "evidence": [ { "id": "XP_059737317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737317" } ] } ], "protein_names": [ { "name": "YEATS domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9SZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7/entry#names_and_taxonomy" } ] }, { "name": "YEATS domain-containing protein 2 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_059737317", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737317" } ] } ], "function": [ { "annotation": "Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RUP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP9#function" }, { "database": "UniProtKB", "id": "ARBA00060245", "url": "https://www.uniprot.org/uniprotkb/ARBA00060245#function" }, { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7#function" }, { "database": "UniProtKB", "id": "A0AAA9T5R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5R9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YEATS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7", "locus": { "chromosome": "1", "start_pos": 83313948, "end_pos": 83416551, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014451", "url": "https://www.ensembl.org/id/ENSBTAG00000014451" } ] } } ], "crossref": [ { "id": "cd16907", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16907", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514192", "url": "https://www.ncbi.nlm.nih.gov/gene/514192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22951", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22951", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737317", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737317", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5R9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRSETPSANHSESDSLSQHNDFLSDKDTNSNMDIEERLSSNTEQRPSRNTGRDTSSIAGSHKTEQRNTDLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDISDAPPSLPLTIPAPMKASSPIKQSHEPVPDTSVEKEGFPANTEAERHTTFYSLPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQGQIPNPESPGKSFQPITMSCKIVSGSPTSKLSTASQASQGTGSPIPKIHGSSFVTSAVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEASHVPTTGAASQLPLPQYVTVKGGHMIAVSPQKQVLTAGEGTAQSPKIQPSKVVGVPVGSTLPSTVKQAVAISGGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAGSSGGGSSSGGGGGGSSGATGGTGGAQNPAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAPGGQASLMKISDSTLKSVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQQSEGTTPGSSSAVGSVMKTSGQQQVCVSQAAVGSCKAPAPSVISATSLVSTPNPISGKATVSGLLKIHSSQSNPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKSPAILPVAAPTPVVPSSAPAAVTKVKTEPETPAPGGPSQDGQTAVKTEDSSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRSDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILNVSEPLKINIKKEQEEKQEEMKLYLPPTPGSEFIGDITQKIGITLQPVALHKNVYASVVEDMLLKATEQLVSDILRQALAVGYQAASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ", "length": 1359, "header": "tr|A0AAA9SZB7-1|A0AAA9SZB7_BOVIN Isoform 1 of YEATS domain-containing protein 2 OS=Bos taurus OX=9913 GN=YEATS2 PE=4 SV=1 CANONICAL=A0AAA9SZB7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7/entry#A0AAA9RUP9-1", "sequence": { "sequence": "MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRSETPSANHSESDSLSQHNDFLSDKDTNSNMDIEERLSSNTEQRPSRNTGRDTSSIAGSHKTEQRNTDLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDISDAPPSLPLTIPAPMKASSPIKQSHEPVPDTSVEKGFPANTEAERHTTFYSLPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQGQIPNPESPGKSFQPITMSCKIVSGSPTSKLSTASQASQGTGSPIPKIHGSSFVTSAVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVVGVPVGSTLPSTVKQAVAISGGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAGSSGGGSSSGGGGGGSSGATGGTGGAQNPAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAPGGQASLMKISDSTLKSVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQQSEGTTPGSSSAVGSVMKTSGQQQVCVSQAAVGSCKAPAPSVISATSLVSTPNPISGKATVSGLLKIHSSQSNPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKSPAILPVAAPTPVVPSSAPAAVTKVKTEPETPAPGGPSQDGQTAVKTEDSSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRSDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILNVSEPLKINIKKEQEEKQEEMKLYLPPTPGSEFIGDITQKIGITLQPVALHKNVYASVVEDMLLKATEQLVSDILRQALAVGYQAASHNRDPGVGRVPLQPLLTTMVLTVKTQSNFSAFDNI", "length": 1294, "header": "tr|A0AAA9RUP9-1|A0AAA9SZB7_BOVIN Computationally mapped isoform of YEATS domain-containing protein 2 OS=Bos taurus OX=9913 GN=YEATS2 PE=4 SV=1 CANONICAL=A0AAA9SZB7-1" }, "locus": { "chromosome": "1", "start_pos": 83395981, "end_pos": 83316122, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105288.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105288.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076960.1" } ] } }, { "isoform_ac": "A0AAA9SZB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7/entry#A0AAA9SZB7-1", "sequence": { "sequence": "MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRSETPSANHSESDSLSQHNDFLSDKDTNSNMDIEERLSSNTEQRPSRNTGRDTSSIAGSHKTEQRNTDLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDISDAPPSLPLTIPAPMKASSPIKQSHEPVPDTSVEKEGFPANTEAERHTTFYSLPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQGQIPNPESPGKSFQPITMSCKIVSGSPTSKLSTASQASQGTGSPIPKIHGSSFVTSAVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEASHVPTTGAASQLPLPQYVTVKGGHMIAVSPQKQVLTAGEGTAQSPKIQPSKVVGVPVGSTLPSTVKQAVAISGGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAGSSGGGSSSGGGGGGSSGATGGTGGAQNPAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAPGGQASLMKISDSTLKSVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQQSEGTTPGSSSAVGSVMKTSGQQQVCVSQAAVGSCKAPAPSVISATSLVSTPNPISGKATVSGLLKIHSSQSNPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKSPAILPVAAPTPVVPSSAPAAVTKVKTEPETPAPGGPSQDGQTAVKTEDSSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRSDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILNVSEPLKINIKKEQEEKQEEMKLYLPPTPGSEFIGDITQKIGITLQPVALHKNVYASVVEDMLLKATEQLVSDILRQALAVGYQAASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ", "length": 1359, "header": "tr|A0AAA9SZB7-1|A0AAA9SZB7_BOVIN Isoform 1 of YEATS domain-containing protein 2 OS=Bos taurus OX=9913 GN=YEATS2 PE=4 SV=1 CANONICAL=A0AAA9SZB7-1" }, "locus": { "chromosome": "1", "start_pos": 83395981, "end_pos": 83315573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123719.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123719.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091797.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091797.1" } ] } }, { "isoform_ac": "A0AAA9T5R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7/entry#A0AAA9T5R9-1", "sequence": { "sequence": "MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRSETPSANHSESDSLSQHNDFLSDKDTNSNMDIEERLSSNTEQRPSRNTGRDTSSIAGSHKTEQRNTDLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDISDAPPSLPLTIPAPMKASSPIKQSHEPVPDTSVEKEGFPANTEAERHTTFYSLPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQGQIPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTTSSVINNPYVIVDKPGQVIGASTPTAGSPTSKLSTASQASQGTGSPIPKIHGSSFVTSAVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVVGVPVGSTLPSTVKQAVAISGGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAGSSGGGSSSGGGGGGSSGATGGTGGAQNPAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAPGGQASLMKISDSTLKSVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQQSEGTTPGSSSAVGSVMKTSGQQQVCVSQAAVGSCKAPAPSVISATSLVSTPNPISGKATVSGLLKIHSSQSNPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKSPAILPVAAPTPVVPSSAPAAVTKVKTEPETPAPGGPSQDGQTAVKTEDSSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRSDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILNVSEPLKINIKKEQEEKQEEMKLYLPPTPGSEFIGDITQKIGITLQPVALHKNVYASVVEDMLLKATEQLVSDILRQALAVGYQAASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ", "length": 1351, "header": "tr|A0AAA9T5R9-1|A0AAA9T5R9_BOVIN Computationally mapped isoform of YEATS domain-containing protein 2 OS=Bos taurus OX=9913 GN=YEATS2 PE=4 SV=1 CANONICAL=A0AAA9SZB7-1" }, "locus": { "chromosome": "1", "start_pos": 83395981, "end_pos": 83315573, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092072.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1032, "start_aa": "Thr", "end_pos": 1032, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1032", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1262, "start_aa": "Thr", "end_pos": 1262, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1262", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 913, "start_aa": "Thr", "end_pos": 913, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr913", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "pmid": "" }, { "name": "ATAC complex", "id": "GO:0140672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "pmid": "" }, { "name": "regulation of cell division", "id": "GO:0051302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051302", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1235, "end_pos": 1237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 998, "end_pos": 1000, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SZB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZB7" }, { "id": "PS51037", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "YEATS", "eco_id": "ECO_0000259", "start_pos": 201, "end_pos": 346, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 913, 1032, 1262 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1235, 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SWY4-1", "uniprot_ac": "A0AAA9SWY4", "uniprot_id": "A0AAA9SWY4_BOVIN", "mass": { "chemical_mass": 19096.0, "monoisotopic_mass": 19096.0 }, "refseq": { "ac": "XP_024840771", "name": "serine/threonine-protein phosphatase CPPED1 isoform X3", "summary": "", "url": 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cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MPJ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPJ7#function" }, { "database": "UniProtKB", "id": "ARBA00024771", "url": "https://www.uniprot.org/uniprotkb/ARBA00024771#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPPED1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4", "locus": { "chromosome": "25", "start_pos": 11392982, "end_pos": 11531489, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007142", "url": "https://www.ensembl.org/id/ENSBTAG00000007142" } ] } } ], 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"ENSBTAP00000007071.5", "url": "https://www.ensembl.org/id/ENSBTAP00000007071.5" } ] } }, { "isoform_ac": "A0A3Q1MPJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4/entry#A0A3Q1MPJ7-1", "sequence": { "sequence": "MCTSSRTPVGAAPRGLGIAIATAPPARGASRGSCERGVPGLGVRQSWNFVGLDRGSRREDKKKEREWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFVLCGDLVHAMPGRPWRKEQTEDLQRVLRTVDSDIPLVLVSGNHDVGNVPTPETIAEFQRTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQEHDHWLDQQLRTAGQRACRHAVVFQHIPLFLQSIGEDDDYFNLTKSVRKEMADKFVEAGVKAVFSGHYHRNAGGTYRNLDMVVSSAIGCQLGTDTHGLRVVVVTAEKITHRYYSLDELSEKGIEDDLMDLLKEN", "length": 351, "header": "tr|A0A3Q1MPJ7-1|A0A3Q1MPJ7_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase CPPED1 OS=Bos taurus OX=9913 GN=CPPED1 PE=3 SV=1 CANONICAL=A0AAA9SWY4-1" }, "locus": { "chromosome": "25", "start_pos": 11531247, "end_pos": 11393986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067144.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067144.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071583.1" } ] } }, { "isoform_ac": "A0AAA9SWY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4/entry#A0AAA9SWY4-1", "sequence": { "sequence": "MSTAEAGGVFHRARGRTLDAFSSEKEREWKGPFYFIQGADPQFGLMKAWATGDCDNGGDEWEQEIRLAEQAVQAINKLNPKPKFFVLCGDLVHAMPGVKAVFSGHYHRNAGGTYRNLDMVVSSAIGCQLGTDTHGLRVVVVTAEKITHRYYSLDELSEKGIEDDLMDLLKEN", "length": 172, "header": "tr|A0AAA9SWY4-1|A0AAA9SWY4_BOVIN Isoform 1 of Calcineurin like phosphoesterase domain containing 1 OS=Bos taurus OX=9913 GN=CPPED1 PE=4 SV=1 CANONICAL=A0AAA9SWY4-1" }, "locus": { "chromosome": "25", "start_pos": 11531386, "end_pos": 11393986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120269.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120269.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089828.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089828.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:537938", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537938", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PJC6-1", "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "CPPED1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSVMAAVGDVFRRARGRTLTAFRQGDEYQWKGPFYFIQGADPQFGLIKAWAVGNTGSGDDEWGEEIKLTEQAVQAINKLNPKPKFFVLCGDLIHGMPGTQWRKDQEQDLKNVLKNTDQDIPLVFVSGNHDIGNTPTRETIDNYCKSWGDDYFSFWVGGVFFLVLNSQLYFDSSKCPELKQAQDAWLNGQLAAAEKRKCKHIIVFQHIPLFLRKPDEDHDYFNLEKSVRQEIMEKFQNAGVKAVFSGHYHRNAGGWYRGLEMVVSSAIGCQLGEDKHGLRVVLVTDEKIVHRYYSLDELSSQGLEKEMVDMLAKQN", "length": 315 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A3L7HBF4-1", "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "Cpped1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSFAEAGDVFHRARGRTLDAFSSEKEKEWKGPFYFIQGADPQFGLMKAWSTGDCDNGGDEWEQEIRLTEKAVEAINKLSPKPKFFVLCGDLIHAMPGTPWQKEQTKDLQQVLKAVHKDIPLVFVSGNHDLGNVPTAETVKDFCQTWGDDYFSFWVGGVLFLVLNSQFFYDASKCPALKQAQDRWLDQQLSIAGQQRCQHAIVFQHIPLFLQSIDEEDDYFNLTKAVRKELADKFTRAGIKAVFSGHYHRNAGGTYQDLDMVVSSAIGCQLGKDTHGLRVVVITAEKIIHRYYSLDELNKRGIDDDLKELMKE", "length": 312 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A5G2QFL2-1", "protein_name": "Calcineurin like phosphoesterase domain containing 1", "gene_name": "CPPED1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAEEAGDVFHRARGRTLDAFSSEKEREWKGPFYFIQGADPQFGLMKAWSTGDCDNGGDEWGQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGVKAVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDSHGLRVVVVTAENIVHRYYSLDELSEKGIDDDLLDLMKEK", "length": 172 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q66H71-1", "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "Cpped1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAAGAADVFHRARGRTLDAFSSEKEREWTGPFYFVQGADPQFGLMKAWSTGNCDNGGDEWGQEIRLTEQAVEAINKLNPKPKFFVLCGDLVHAMPGTRWRKEQTRDLQRVLKVVDQDIPLVLVSGNHDLGNAPTAETVEEFCQTWGDDYFSFWVGGALFLVLNSQFLYDASKCPALKQAQDHWLDQQLSIAEQQQCQHAIVFQHIPLFLKSIDEDDDYFNLTKTVRQELADKFTRAGIRAVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGKDTHGLRVVVVTAEKIVHRYYSLDELSKRGLDDDLRELLKE", "length": 312 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BFS6-1", "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "Cpped1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAMEAADVFHRARGRTLDAFSSEKEREWKGPFYFVQGADTQFGLMKAWSTGNCDAGGDEWGQEIRLTEQAVEAINKLNPKPKFFVLCGDLVHAMPGTPWRQEQTRDLQRVLKAVDQDIPLVMVSGNHDLGNAPTAETVEEFCQTWGDDYFSFWVGGVLFLVLNSQFLYDASRCPALKQAQDHWLDQQLNIAEQKQCQHAIVFQHIPLFLQSIDEDDDYFNLTKTVRKELAEKLTRAGIRAVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGKDTHGLRVVAITAEKIVHRYYSLDELSQGGVEEDLKELLKE", "length": 312 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BRF8-1", "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "CPPED1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFGLIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRTEQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLFLVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDDYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPHGLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK", "length": 314 }, "evidence": [ { "id": "A0AAA9SWY4", "url": "https://omabrowser.org/oma/group/A0AAA9SWY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SWY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] }, { "id": "R-BTA-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O77834-1", "Q29451-1", "P07514-1", "A0JNA3-1", "Q32PF2-1", "Q3MI05-1", "F1MUP9-1", "H7BWW2-1", "Q08DD1-1", "Q2KIM0-1", "Q3ZBH0-1", "F1MU24-1", "A0AAA9U1E9-1", "A0ABI0NJH4-1", "F1N144-1", "F1N5H2-1", "P80189-1", "P46196-1", "A7YWG4-1", "E1BPI3-1", "A0AAA9SWY4-1", "A0A3Q1LUG9-1", "F1MGY9-1", "G3X757-1", "A0A3Q1NDQ7-1", "Q2KJ64-1", "Q3ZCI9-1", "E1B725-1" ], "evidence": [ { "id": "R-BTA-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAA9U1E9", "gene_name": "GALNS", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1B725", "gene_name": "GLA", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGY9", "gene_name": "AGA", "activity": [ { "ec_number": "3.5.1.26", "activity": "N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] }, { "ec_number": "3.5.1.26", "activity": "", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MU24", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] } ] }, { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N144", "gene_name": "ADA2", "activity": [ { "ec_number": "3.5.4.4", "activity": "2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+).", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] }, { "ec_number": "3.5.4.4", "activity": "", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N5H2", "gene_name": "FUCA2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "H7BWW2", "gene_name": "HEXB", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "O77834", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] } ] }, { "uniprot_ac": "P07514", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "P80189", "gene_name": "LYS", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] } ] }, { "uniprot_ac": "Q08DD1", "gene_name": "ARSA", "activity": [ { "ec_number": "3.1.6.8", "activity": "an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+).", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] }, { "ec_number": "3.1.6.8", "activity": "", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q29451", "gene_name": "MAN2B1", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] } ] }, { "uniprot_ac": "Q2KIM0", "gene_name": "FUCA1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM0" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM0" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJ64", "gene_name": "ARG1", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3MI05", "gene_name": "CTSA", "activity": [ { "ec_number": "3.4.16.5", "activity": "Release of a C-terminal amino acid with broad specificity.", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] }, { "ec_number": "3.4.16.5", "activity": "", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] }, { "ec_number": "3.4.16.-", "activity": "", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] } ] }, { "uniprot_ac": "Q3SWW9", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] } ] }, { "uniprot_ac": "Q3T0E7", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q58DC0", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q58DC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DC0" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.16", "ec_name": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16" }, { "id": "3.1.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.16" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXM1-1", "uniprot_ac": "A0AAA9SXM1", "uniprot_id": "A0AAA9SXM1_BOVIN", "mass": { "chemical_mass": 195387.0, "monoisotopic_mass": 195387.0 }, "refseq": { "ac": "XP_059734340", "name": "trinucleotide repeat-containing gene 6C protein isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734340" }, "gene_names": [ { "name": "TNRC6C", "type": "recommended", "evidence": [ { "id": "A0AAA9SXM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ] }, { "name": "TNRC6C", "type": "synonym", "evidence": [ { "id": "XP_059734340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734340" } ] } ], "protein_names": [ { "name": "Trinucleotide repeat-containing gene 6C protein", "type": "recommended", "evidence": [ { "id": "A0AAA9SXM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#names_and_taxonomy" } ] }, { "name": "trinucleotide repeat-containing gene 6C protein isoform X4", "type": "synonym", "evidence": [ { "id": "XP_059734340", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734340" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNRC6C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1", "locus": { "chromosome": "19", "start_pos": 54050771, "end_pos": 54164578, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018658", "url": "https://www.ensembl.org/id/ENSBTAG00000018658" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018658", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018658", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12713", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12713", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14283", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14283", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504217", "url": "https://www.ncbi.nlm.nih.gov/gene/504217", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019486", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019486", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041917", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041917", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052068", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052068", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M629", "url": "https://www.orthodb.org/?gene=A0A3Q1M629", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N906", "url": "https://www.orthodb.org/?gene=A0A3Q1N906", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MLT5", "url": "https://www.orthodb.org/?gene=F1MLT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13020:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13020:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00627", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00627", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10427", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10427", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16608", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16608", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426496", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426496", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059734340", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734340", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M629", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M629", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M629-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M629-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N906", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N906", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N906-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N906-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLT5", "url": "https://www.uniprot.org/uniprotkb/F1MLT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTLSSGSNGKRASASGQQPAAARYLPREVPPRFRQQEQKQLLKRGQPLPAGALTSVSPTQGAGPAGLSPPPLPGAGAQPHPSKPQPDLSHSGPAEHYESSHWGQQPTYRSEASCSWEKTLSDRTDAGAWPSITGAETESASECTTDTDSASNCGSENSSMATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPVSSGWGEMPNVHSKAENSWGESSSPSTLVDNGTAAWGKPPSSGSGWGDQPTEPALTFGRASAPAAAPALCKPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSGSAWSTDASGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGHAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQPSPGTSQTRLGTSGSAHGLVRSDAGHWNAPGLAGKGSSDLLWGGVPQYSSSLWGPPSSDDGRVIGSPTPLNTLLPGDLLSGESI", "length": 1895, "header": "tr|A0AAA9SXM1-1|A0AAA9SXM1_BOVIN Isoform 1 of Trinucleotide repeat-containing gene 6C protein OS=Bos taurus OX=9913 GN=TNRC6C PE=3 SV=1 CANONICAL=A0AAA9SXM1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M629-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#A0A3Q1M629-1", "sequence": { "sequence": "MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTLSSGSNGKRASASGQQPAAARYLPREVPPRFRQQEQKQLLKRGQPLPAGALTSVSPTQGAGPAGLSPPPLPGAGAQPHPSKPQPDLSHSGPAEHYESSHWGQQPTYRSEASCSWEKTLSDRTDAGAWPSITGAETESASECTTDTDSASNCGSENSSMATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQMVPTPTCVPVPCGAQCYFSALEHDGLVVGYLKPALCGFCDLQMWTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSGSAWSTDASGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGHAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQPSPGTSQTRLGTSGSAHGLVRSDAGHWNAPGLAGKGSSDLLWGGVPQYSSSLWGPPSSDDGRVIGSPTPLNTLLPGDLLSGESI", "length": 1867, "header": "tr|A0A3Q1M629-1|A0A3Q1M629_BOVIN Computationally mapped isoform of Trinucleotide repeat-containing gene 6C protein OS=Bos taurus OX=9913 GN=TNRC6C PE=3 SV=2 CANONICAL=A0AAA9SXM1-1" }, "locus": { "chromosome": "19", "start_pos": 54125302, "end_pos": 54051775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081636.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081636.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063742.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063742.2" } ] } }, { "isoform_ac": "A0A3Q1N906-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#A0A3Q1N906-1", "sequence": { "sequence": "MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTLSSGSNGKRASASGQQPAAARYLPREVPPRFRQQEQKQLLKRGQPLPAGALTSVSPTQGAGPAGLSPPPLPGAGAQPHPSKPQPDLSHSGPAEHYESSHWGQQPTYRSEASCSWEKTLSDRTDAGAWPSITGAETESASECTTDTDSASNCGSENSSMATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKLTLSFPNQDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNAALPPSSAWPLAASGHSRAFSSLAPAPTVAGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSGSAWSTDASGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGHAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQPSPGTSQTRLGTSGSAHGLVRSDAGHWNAPGLAGKGSSDLLWGGVPQYSSSLWGPPSSDDGRVIGSPTPLNTLLPGDLLSGESI", "length": 1870, "header": "tr|A0A3Q1N906-1|A0AAA9SXM1_BOVIN Computationally mapped isoform of Trinucleotide repeat-containing gene 6C protein OS=Bos taurus OX=9913 GN=TNRC6C PE=3 SV=2 CANONICAL=A0AAA9SXM1-1" }, "locus": { "chromosome": "19", "start_pos": 54125302, "end_pos": 54051775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077012.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077012.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067592.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067592.2" } ] } }, { "isoform_ac": "A0AAA9SXM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#A0AAA9SXM1-1", "sequence": { "sequence": "MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTLSSGSNGKRASASGQQPAAARYLPREVPPRFRQQEQKQLLKRGQPLPAGALTSVSPTQGAGPAGLSPPPLPGAGAQPHPSKPQPDLSHSGPAEHYESSHWGQQPTYRSEASCSWEKTLSDRTDAGAWPSITGAETESASECTTDTDSASNCGSENSSMATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPVSSGWGEMPNVHSKAENSWGESSSPSTLVDNGTAAWGKPPSSGSGWGDQPTEPALTFGRASAPAAAPALCKPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSGSAWSTDASGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGHAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQPSPGTSQTRLGTSGSAHGLVRSDAGHWNAPGLAGKGSSDLLWGGVPQYSSSLWGPPSSDDGRVIGSPTPLNTLLPGDLLSGESI", "length": 1895, "header": "tr|A0AAA9SXM1-1|A0AAA9SXM1_BOVIN Isoform 1 of Trinucleotide repeat-containing gene 6C protein OS=Bos taurus OX=9913 GN=TNRC6C PE=3 SV=1 CANONICAL=A0AAA9SXM1-1" }, "locus": { "chromosome": "19", "start_pos": 54125302, "end_pos": 54051775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102537.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102537.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088968.1" } ] } }, { "isoform_ac": "A0AAA9TIA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#A0AAA9TIA1-1", "sequence": { "sequence": "MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTLSSGSNGKRASASGQQPAAARYLPREVPPRFRQQEQKQLLKRGQPLPAGALTSVSPTQGAGPAGLSPPPLPGAGAQPHPSKPQPDLSHSGPAEHYESSHWGQQPTYRSEASCSWEKTLSDRTDAGAWPSITGAETESASECTTDTDSASNCGSENSSMATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNAALPPSSAWPLAASGHSRAFSSLAPAPTVAGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSGSAWSTDASGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGHAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQPSPGTSQTRLGTSGSAHGLVRSDAGHWNAPGLAGKGSSDLLWGGVPQYSSSLWGPPSSDDGRVIGSPTPLNTLLPGDLLSGESI", "length": 1862, "header": "tr|A0AAA9TIA1-1|A0AAA9TIA1_BOVIN Computationally mapped isoform of Trinucleotide repeat-containing gene 6C protein OS=Bos taurus OX=9913 GN=TNRC6C PE=3 SV=1 CANONICAL=A0AAA9SXM1-1" }, "locus": { "chromosome": "19", "start_pos": 54125302, "end_pos": 54051775, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118274.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118274.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098023.1" } ] } }, { "isoform_ac": "F1MLT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1/entry#F1MLT5-1", "sequence": { "sequence": "MATGSAQGSFTGQTKKTNGNNGSNGTLVQNPSAQSALGAGGANSNGGAARVWGVAASAGSGLAHCSLGGGDGKMDNMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVGTGNPSSICSPVSAIGQNMGTQNGNPAGTLGAWGNLLPQESTGPQTSTSQNVSFSAQPQNLNTDGPNNTNPLSPSPSPLNAVQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVGGGGGEGIGSSVWGLSPGNPATGNSGSGFSQGNGDTVNSALSAKQNGSSSAVQKEGNGGNNAWDSGPPAGPGILAWGRGGGSSGVGNLHSGAWGHPSRSTSNGVNGDWGKPPNQHSSSDINGKGSTGWDSPSAGGQNPAAQPGSEHVNSWAKAASSGTSASEGSSDGSGSHHEGSTGRDGAEGRRRDKGVLEQGHLQLPRSDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQPSHSGGKNDGSSVNSTNTSSVSGWVSSPPAAAPAHAGWGDSSHKAPNGPGVWGEAISSTAVNNAAAAKSGHAWSGTVNQEDKSPTWAEPQKPRSQNWGDGHKPNPAWSAGGGDWADSSSVLGHLGEGKKNASGWDADSSRSGSGWNEAPRSGTGGWGNGTNAKVNPGTSWGESLKPGPQQNWASKPPDSSSSNWGGAASVKQTGTGWIGGPLPVKPKDTSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPGIQSSASAGAAATATATATSDSASAAEAPPAHQASAQLSRSPLLGPVSSGWGEMPNVHSKAENSWGESSSPSTLVDNGTAAWGKPPSSGSGWGDQPTEPALTFGRASAPAAAPALCKPASKSMQEGWGSGGDDANLGASQWEDEDGGMWNNAASQESPSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMTRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDYNGMVTKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTTSPFLPSPSLKPPLSNSALPSQALGGIASGLGMQNLNSARQTPSGNLGMFGSSGAAPARTMQQPPQPPVPPLSSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGPMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKPPPPPHLSLHPSAGKSALDSFPPHPQAPGLPELQTKEQQSSSPSTFAPYPLAGLNPNMNASSMDMTGGLSVKDPSQSQSRLPQWTHPNPMDNLPGAASPLDQNPSKHGAIPGGLSIGPPAKSSIDDSYGRYDLIQSSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGKLSDIKSTWSSGSASHTQASLSHELWKVPRNTTAPTRPPPGLTNPKPSSAWGASPLGWTSSYSSDRRLHPADAVPAARAPHHVPPEPDAGPRRGPLQLQGGSRQGPEVPAHVCSGKHYHLGRVRRRRRSEPFLSPRPSTATHLQLAAQPRDQPDAAGHLGQRPRPGAERRRPLECPGAGRQREQRPAVGRGPPVLEQPVGPPQQRRRQGHRKPHPAEHVAPWRPSQWGVHLAPGGPAGAAVTSCRRTR", "length": 1679, "header": "tr|F1MLT5-1|F1MLT5_BOVIN Computationally mapped isoform of Trinucleotide repeat containing adaptor 6C OS=Bos taurus OX=9913 GN=TNRC6C PE=4 SV=5 CANONICAL=A0AAA9SXM1-1" }, "locus": { "chromosome": "19", "start_pos": 54091052, "end_pos": 54051722, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061369.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061369.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053234.5", "url": "https://www.ensembl.org/id/ENSBTAP00000053234.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 110, "start_aa": "Thr", "end_pos": 110, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr110", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-426496", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426496", "resource": "Reactome", "description": "Post-transcriptional silencing by small RNAs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0060213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060213", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "id": "GO:1900153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900153", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" }, { "name": "miRNA-mediated post-transcriptional gene silencing", "id": "GO:0035195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035195", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1384, "end_pos": 1386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1480, "end_pos": 1482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1584, "end_pos": 1586, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1626, "end_pos": 1628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1672, "end_pos": 1674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1725, "end_pos": 1727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1751, "end_pos": 1753, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1781, "end_pos": 1783, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, 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"type": "recommended", "evidence": [ { "id": "A0AAA9SXD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024851314", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851314" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP2R2A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4", "locus": { "chromosome": "8", "start_pos": 73620437, "end_pos": 73542087, "strand": "-", "evidence": [ { 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"IPR018067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NQIKWCR", "url": "https://omabrowser.org/oma/group/NQIKWCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVS3", "url": "https://www.orthodb.org/?gene=A0A3Q1MVS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MG56", "url": "https://www.orthodb.org/?gene=F1MG56", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11871", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11871", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024851314", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851314", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG56", "url": "https://www.uniprot.org/uniprotkb/F1MG56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG56-1", "url": "https://www.uniprot.org/uniprotkb/F1MG56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 447, "header": "tr|A0AAA9SXD4-1|A0AAA9SXD4_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=1 CANONICAL=A0AAA9SXD4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#A0A3Q1MVS3-1", "sequence": { "sequence": "MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDRWPQYWSFSFSISPSNEYSGLISFRIDWFDLPAVQGTLKSLLQYHSSKASVLRHSAFQLSTSIHD", "length": 419, "header": "tr|A0A3Q1MVS3-1|A0AAA9SXD4_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=2 CANONICAL=A0AAA9SXD4-1" }, "locus": { "chromosome": "8", "start_pos": 73617465, "end_pos": 73542404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071448.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071448.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059246.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059246.2" } ] } }, { "isoform_ac": "A0AAA9SUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#A0AAA9SUN4-1", "sequence": { "sequence": "MADGMYMATHSSILAWRIPWMRSLAGYSPWGHKESDTTTATWHACNADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 466, "header": "tr|A0AAA9SUN4-1|A0AAA9SXD4_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=1 CANONICAL=A0AAA9SXD4-1" }, "locus": { "chromosome": "8", "start_pos": 73619724, "end_pos": 73560216, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098250.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098250.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087680.1" } ] } }, { "isoform_ac": "A0AAA9SXD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#A0AAA9SXD4-1", "sequence": { "sequence": "MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 447, "header": "tr|A0AAA9SXD4-1|A0AAA9SXD4_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=1 CANONICAL=A0AAA9SXD4-1" }, "locus": { "chromosome": "8", "start_pos": 73619724, "end_pos": 73542404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107153.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107153.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090011.1" } ] } }, { "isoform_ac": "A0AAA9TTP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#A0AAA9TTP1-1", "sequence": { "sequence": "MPLLIDDTLIYISSSFPKLSNLSSFLDDISTYVSGRNQHHRWKMEFWAPFLIQSCSSPADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 478, "header": "tr|A0AAA9TTP1-1|A0AAA9TTP1_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=1 CANONICAL=A0AAA9SXD4-1" }, "locus": { "chromosome": "8", "start_pos": 73619724, "end_pos": 73574588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089246.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089246.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099905.1" } ] } }, { "isoform_ac": "F1MG56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4/entry#F1MG56-1", "sequence": { "sequence": "MFLKFSLRSVFYGSLTLLTLLQAFVPLKKNSDFWYLRFSGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 484, "header": "tr|F1MG56-1|F1MG56_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B OS=Bos taurus OX=9913 GN=PPP2R2A PE=3 SV=3 CANONICAL=A0AAA9SXD4-1" }, "locus": { "chromosome": "8", "start_pos": 73619724, "end_pos": 73543823, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024373.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024373.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024373.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024373.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P36872-1", "protein_name": "Protein phosphatase PP2A 55 kDa regulatory subunit", "gene_name": "tws", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGRWGRQSPVLEPPDPQMQTTPPPPTLPPRTFMRQSSITKIGNMLNTAININGAKKPASNGEASWCFSQIKGALDDDVTDADIISCVEFNHDGELLATGDKGGRVVIFQRDPASKAANPRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLQQKNPVHFLLSTNDKTVKLWKVSERDKSFGGYNTKEENGLIRDPQNVTALRVPSVKQIPLLVEASPRRTFANAHTYHINSISVNSDQETFLSADDLRINLWHLEVVNQSYNIVDIKPTNMEELTEVITAAEFHPTECNVFVYSSSKGTIRLCDMRSAALCDRHSKQFEEPENPTNRSFFSEIISSISDVKLSNSGRYMISRDYLSIKVWDLHMETKPIETYPVHEYLRAKLCSLYENDCIFDKFECCWNGKDSSIMTGSYNNFFRVFDRNSKKDVTLEASRDIIKPKTVLKPRKVCTGGKRKKDEISVDCLDFNKKILHTAWHPEENIIAVAATNNLFIFQDKF", "length": 499 }, "evidence": [ { "id": "A0AAA9SXD4", "url": "https://omabrowser.org/oma/group/A0AAA9SXD4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P63151-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "PPP2R2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 447 }, "evidence": [ { "id": "A0AAA9SXD4", "url": "https://omabrowser.org/oma/group/A0AAA9SXD4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q00362-1", "protein_name": "Protein phosphatase PP2A regulatory subunit B", "gene_name": "CDC55", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAQNNFDFKFSQCFGDKADIVVTEADLITAVEFDYTGNYLATGDKGGRVVLFERSNSRHCEYKFLTEFQSHDAEFDYLKSLEIEEKINEIKWLRPTQRSHFLLSTNDKTIKLWKVYEKNIKLVSQNNLTEGVTFAKKGKPDNHNSRGGSVRAVLSLQSLKLPQLSQHDKIIAATPKRIYSNAHTYHINSISLNSDQETFLSADDLRINLWNLDIPDQSFNIVDIKPTNMEELTEVITSAEFHPQECNLFMYSSSKGTIKLCDMRQNSLCDNKTKTFEEYLDPINHNFFTEITSSISDIKFSPNGRYIASRDYLTVKIWDVNMDNKPLKTINIHEQLKERLSDTYENDAIFDKFEVNFSGDSSSVMTGSYNNNFMIYPNVVTSGDNDNGIVKTFDEHNAPNSNSNKNIHNSIQNKDSSSSGNSHKRRSNGRNTGMVGSSNSSRSSIAGGEGANSEDSGTEMNEIVLQADKTAFRNKRYGSLAQRSARNKDWGDDIDFKKNILHFSWHPRENSIAVAATNNLFIFSAL", "length": 526 }, "evidence": [ { "id": "A0AAA9SXD4", "url": "https://omabrowser.org/oma/group/A0AAA9SXD4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54Q99-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB", "gene_name": "phr2aB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTEPLDWRFSQTFGGKGNEDASDANVVPAIEFDQTGDFIAVGDKGGKVLLLKRTHDKQSSKKSKLPEYRFYSEFQSHEPEFDYLKSLEIEEKINKIKWCPKQNDAQFLLTTNDKTIKLWKVYEKKIKQVSTSATTTGPSYNGSLASNNTRSPSHTTYIYNSSGAHNMNNNMNNSNNNNNLNNFKIPKLTTRETVVTATPRKIFQNAHAYHINSISLNSDGETYISSDDLRIHLWNLNINTECFNVVDIKPTNMEDLTEVITSAEFHPTSCNIFMYSSSKGTIKLGDLRSSALCDNHAKVFEEYEDPSNKSFFSEIISSISDIKFSRDGRYILSRDFLTLKLWDINMENKPVKTIQIHDYLKPKLCDLYENDCIFDKFECTLNHDGTQMLTGSYHNYLHIYDRNSKQDVCLEASKQATKSKTKTLTTKMKLRSSKKEPKKPEDIHPDAIEYTKKTLHCAWHPKDNLIAVGAANTVYLYAATENK", "length": 483 }, "evidence": [ { "id": "A0AAA9SXD4", "url": "https://omabrowser.org/oma/group/A0AAA9SXD4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6P1F6-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "Ppp2r2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN", "length": 447 }, "evidence": [ { "id": "A0AAA9SXD4", "url": "https://omabrowser.org/oma/group/A0AAA9SXD4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "protein phosphatase type 2A complex", "id": "GO:0000159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000159", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" }, { "name": "enzyme-substrate adaptor activity", "id": "GO:0140767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140767", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of chromosome segregation", "id": "GO:0051983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 351, "end_pos": 353 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SXL6-1", "uniprot_ac": "A0AAA9SXL6", "uniprot_id": "A0AAA9SXL6_BOVIN", "mass": { "chemical_mass": 55251.0, "monoisotopic_mass": 55251.0 }, "refseq": { "ac": "NP_001179776", "name": "monocarboxylate transporter 10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" }, "gene_names": [ { "name": "SLC16A10", "type": "recommended", "evidence": [ { "id": "A0AAA9SXL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ] }, { "name": "MCT10", "type": "synonym", "evidence": [ { "id": "NP_001179776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" } ] }, { "name": "SLC16A10", "type": "synonym", "evidence": [ { "id": "NP_001179776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" } ] }, { "name": "TAT1", "type": "synonym", "evidence": [ { "id": "NP_001179776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" } ] } ], "protein_names": [ { "name": "Solute carrier family 16 member 10", "type": "synonym", "evidence": [ { "id": "A0AAA9SXL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6/entry#names_and_taxonomy" } ] }, { "name": "monocarboxylate transporter 10", "type": "synonym", "evidence": [ { "id": "NP_001179776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" } ] }, { "name": "solute carrier family 16, member 10 (aromatic amino acid transporter)", "type": "synonym", "evidence": [ { "id": "NP_001179776", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776" } ] } ], "function": [ { "annotation": "Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels. Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa). Plays an important role in homeostasis of aromatic amino acids.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TTW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTW6#function" }, { "database": "UniProtKB", "id": "ARBA00058829", "url": "https://www.uniprot.org/uniprotkb/ARBA00058829#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC16A10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6", "locus": { "chromosome": "9", "start_pos": 39167421, "end_pos": 39281015, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009239", "url": "https://www.ensembl.org/id/ENSBTAG00000009239" } ] } } ], "crossref": [ { "id": "A0AAA9SXL6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SXL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009239", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009239", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17464", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17464", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541240", "url": "https://www.ncbi.nlm.nih.gov/gene/541240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541240", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541240", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LSYRIWA", "url": "https://omabrowser.org/oma/group/LSYRIWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEU4", "url": "https://www.orthodb.org/?gene=F1MEU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11360:SF119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11360:SF119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179776", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "27950", "url": "https://www.rhea-db.org/rhea/27950", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "68572", "url": "https://www.rhea-db.org/rhea/68572", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70947", "url": "https://www.rhea-db.org/rhea/70947", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71811", "url": "https://www.rhea-db.org/rhea/71811", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71819", "url": "https://www.rhea-db.org/rhea/71819", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEU4", "url": "https://www.uniprot.org/uniprotkb/F1MEU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEU4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPSQEEPAAARGTSEAQPPGSAPPGAAPLPCAGPLDGPEAAAAEKVEVELGGSVGAEPLEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLKTFGSKDDDKMVFKTAWVSSLSMGMIFFCCPIVSVFTDIFGCRKTAVVGAAVGFVGLLSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSIFTILLPFLLRVLTDSVGLFHTLRVLCIFVFVLFLAGFTYRPFASSAKDKDGTTKGGNRLSLFSRRKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKYVNERFQDEKNKEVVLMCIGITSGVGRLLFGRIADYVPGVKKIYLQVLSFLFIGLMSMMIPLCSVFGGLIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGIPPLIGGAVLCFIPWVHSKKQREVTKTTGGEKMEKMLANQNSLSSSSAIFKKESDSVI", "length": 515, "header": "tr|A0AAA9SXL6-1|A0AAA9SXL6_BOVIN Isoform 1 of Solute carrier family 16 member 10 OS=Bos taurus OX=9913 GN=SLC16A10 PE=3 SV=1 CANONICAL=A0AAA9SXL6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXL6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6/entry#A0AAA9SXL6-1", "sequence": { "sequence": "MVPSQEEPAAARGTSEAQPPGSAPPGAAPLPCAGPLDGPEAAAAEKVEVELGGSVGAEPLEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLKTFGSKDDDKMVFKTAWVSSLSMGMIFFCCPIVSVFTDIFGCRKTAVVGAAVGFVGLLSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSIFTILLPFLLRVLTDSVGLFHTLRVLCIFVFVLFLAGFTYRPFASSAKDKDGTTKGGNRLSLFSRRKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKYVNERFQDEKNKEVVLMCIGITSGVGRLLFGRIADYVPGVKKIYLQVLSFLFIGLMSMMIPLCSVFGGLIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGIPPLIGGAVLCFIPWVHSKKQREVTKTTGGEKMEKMLANQNSLSSSSAIFKKESDSVI", "length": 515, "header": "tr|A0AAA9SXL6-1|A0AAA9SXL6_BOVIN Isoform 1 of Solute carrier family 16 member 10 OS=Bos taurus OX=9913 GN=SLC16A10 PE=3 SV=1 CANONICAL=A0AAA9SXL6-1" }, "locus": { "chromosome": "9", "start_pos": 39280816, "end_pos": 39168425, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114214.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114214.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088963.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088963.1" } ] } }, { "isoform_ac": "A0AAA9TTW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6/entry#A0AAA9TTW6-1", "sequence": { "sequence": "MVPSQEEPAAARGTSEAQPPGSAPPGAAPLPCAGPLDGPEAAAAEKVEVELGGSVGAEPLEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLKTFGSKDDDKMVFKTAWVSSLSMGMIFFCCPIVSVFTDIFGCRKTAVVGAAVGFVGLLSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSIFTILLPFLLRVLTDSVGLFHTLRVLCIFVFVLFLAGFTYRPFASSAKDKDGTTKGGNRLSLFSRRKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKYVNERFQDEKNKEVVLMCIGITSGVGRLLFGRIADYVPGVKKIYLQVLSFLFIGLMSMMIPLCSVFGGLIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGTRKVCKCKHFEACVYDRFQLGGPSTFSRNRTLTPCVRIPKGPLKGFEKAKA", "length": 491, "header": "tr|A0AAA9TTW6-1|A0AAA9TTW6_BOVIN Computationally mapped isoform of Monocarboxylate transporter 10 OS=Bos taurus OX=9913 GN=SLC16A10 PE=3 SV=1 CANONICAL=A0AAA9SXL6-1" }, "locus": { "chromosome": "9", "start_pos": 39280816, "end_pos": 39168926, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107906.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107906.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101807.1" } ] } }, { "isoform_ac": "F1MEU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6/entry#F1MEU4-1", "sequence": { "sequence": "MVPSQEEPAAARGTSEAQPPGSAPPGAAPLPCAGPLDGPEAAAAEKVEVELGGSVGAEPLEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLKTFGSKDDDKMVFKTAWVSSLSMGMIFFCCPIVSVFTDIFGCRKTAVVGAAVGFVGLLSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSIFTILLPFLLRVLTDSVGLFHTLRVLCIFVFVLFLAGFTYRPFASSAKDKDGTTKGGNRLSLFSRRKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKYVNERFQDEKNKEVVLMCIGITSGVGRLLFGRIADYVPGVKKIYLQCQALLHGFPRELRSTGRCFQVLSFLFIGLMSMMIPLCSVFGGLIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGIPPLIGGAVLCFIPWVHSKKQREVTKTTGGEKMEKMLANQNSLSSSSAIFKKESDSVI", "length": 535, "header": "tr|F1MEU4-1|F1MEU4_BOVIN Computationally mapped isoform of Solute carrier family 16 member 10 OS=Bos taurus OX=9913 GN=SLC16A10 PE=3 SV=3 CANONICAL=A0AAA9SXL6-1" }, "locus": { "chromosome": "9", "start_pos": 39280816, "end_pos": 39168425, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012176.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012176.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012176.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012176.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541240", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541240", "resource": "KEGG Pathway" }, { "id": "R-BTA-352230", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "resource": "Reactome", "description": "Amino acid transport across the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A1L1W9-1", "protein_name": "Monocarboxylate transporter 10", "gene_name": "slc16a10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTEPEPTLEQEPTPEPEPTQEPTPEPTPEPEPTQEPESEPELELKQENGCTKASEQKSPEEFEPPEGGWGWVVMLASMWCNGSVFGIQNAFGIMFVYLLNEFGSEHDADLRFKTAWVGSLSMGMIFFCSPIVSVFTDLLGCRITAVGGAAVGCVGLLASSFVTSLGPMYFTYGIVFACGCSFAYQPSLVILGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGLLKSVGLYHTLRVLAIFMFILMLAGLTYKPLLPKPVSSSKPGSRCPPLSRIFNVNIWKSLGYRIWAFGIPAALYGYFVPYVHLMTHVEERFGPEANKEVLLACIGITSGVGRLIFGRVADYVPGVNKVFLQVSSFMVIGVMSMMIPLCHVFGGLIAVCLLMGLFDGCFICIMAPIAFELVGSQNVSQAIGFLLGMMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGIPPLIGGAVLCAIPWVEARRKRREAANTAENTEKMLESRSPPLEDTVCRTEEPESVI", "length": 505 }, "evidence": [ { "id": "A0AAA9SXL6", "url": "https://omabrowser.org/oma/group/A0AAA9SXL6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LR83-1", "protein_name": "Solute carrier family 16 member 10", "gene_name": "SLC16A10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVRSQEEPAAARGTSEAQPAGPAPLGAAPLPGSGPLDGPEAVAAEKVEVELVGPAGAEPPEPPEGGWGWVVMLAAMWCNGSVFGFQNACGVLFVSMLKTFGSKDDDKMVFKTAWVNSLSMGMIFFCCPIVSVFTDMFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSIFTILLPFLLRVLTDSMGLFHTLRALCVFMFVLFLAGFTYRPLASSTKEKEGTKGGNRAALFSRRKFSPPKKIFNFAIFRVTAYAVWAIGIPLALFGYFVPYVHLMKHMNDRFQDEKNKEVVLMCIGITSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGIPPIIGGVVLCFIPWLHIKKQREISKTAGEEKMEKMLENQNSLLSSSSGIFKKESDSVI", "length": 515 }, "evidence": [ { "id": "A0AAA9SXL6", "url": "https://omabrowser.org/oma/group/A0AAA9SXL6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U9N9-1", "protein_name": "Monocarboxylate transporter 10", "gene_name": "Slc16a10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPSQEEPAAERETNEAQPPGPAPSDDAPLPGPGPSDVSDVAAEKVEVELTRSAGSEPPVPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLDTFKAKDDDNMAFKTAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVVGAAVGFIGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLISSVKLFNTLRILCIFMFVLFLAGFTYRPLVPSTKEKESGGSRSSFFSRRKLSPPKKVFNFALFKETTYAVWAAGIPLALFGYFVPYVHLMNHVKERFQDVNNKEVLFMCIGITSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLMSMMIPLCSAFGALIAVCLAMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPIAGLLHDKLGTYDVAFYLAGIPPFVGGVVLCLIPWIHSKKQRKISKNAGGEKMEKMLENQSSLLSGSSGIFKKDSASII", "length": 512 }, "evidence": [ { "id": "A0AAA9SXL6", "url": "https://omabrowser.org/oma/group/A0AAA9SXL6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TF71-1", "protein_name": "Monocarboxylate transporter 10", "gene_name": "SLC16A10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII", "length": 515 }, "evidence": [ { "id": "A0AAA9SXL6", "url": "https://omabrowser.org/oma/group/A0AAA9SXL6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91Y77-1", "protein_name": "Monocarboxylate transporter 10", "gene_name": "Slc16a10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVPSQEEPAAAERETNEAQPPGPAPSDDAPLPVPGPSDVSDGSVEKVEVELTRSTGNQEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLETFGAKDDDNMAFKAAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVLGAAVGFVGLMSSSFVSSIEPLYFTYGVVFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLTSTVGLCYTLRILCIFMFVLFLAGFTYRPLVPSSKEKESEDSRSSFFSRRKLSPPKKIFNFALFKETAYAVWAAGIPLALFGYFVPYVHLMNHVKERFKDVNNKEVLFMCIGVTSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLTSMMIPLCSVFGALIALCLIMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPVAGLLHDKLGSYDLAFYLAGIPPFIGGAVLCLIPWIHSKKQREISKNTGGEKMEKMLANQSSLLSSSSGIFKKESDSII", "length": 514 }, "evidence": [ { "id": "A0AAA9SXL6", "url": "https://omabrowser.org/oma/group/A0AAA9SXL6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "thyroid hormone transmembrane transporter activity", "id": "GO:0015349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015349", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "L-tryptophan transmembrane transporter activity", "id": "GO:0015196", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015196", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "L-tyrosine transmembrane transporter activity", "id": "GO:0005302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005302", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "L-phenylalanine transmembrane transporter activity", "id": "GO:0015192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "thyroid hormone transport", "id": "GO:0070327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070327", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "27950", "name": "", "equation": "L-phenylalanine(in) = L-phenylalanine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "27950", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27950" } ] }, { "id": "68572", "name": "", "equation": "L-tyrosine(in) = L-tyrosine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "68572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/68572" } ] }, { "id": "70947", "name": "", "equation": "L-tryptophan(in) = L-tryptophan(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "70947", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70947" } ] }, { "id": "71811", "name": "", "equation": "3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71811" } ] }, { "id": "71819", "name": "", "equation": "L-thyroxine(out) = L-thyroxine(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71819", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71819" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SXL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXL6" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 515, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SY73-1", "uniprot_ac": "A0AAA9SY73", "uniprot_id": "A0AAA9SY73_BOVIN", "mass": { "chemical_mass": 23826.0, "monoisotopic_mass": 23826.0 }, "refseq": {}, "gene_names": [ { "name": "TAF12", "type": "recommended", "evidence": [ { "id": "A0AAA9SY73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ] } ], "protein_names": [ { "name": "Transcription initiation factor TFIID subunit 12", "type": "recommended", "evidence": [ { "id": "A0AAA9SY73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73#function" }, { "database": "UniProtKB", "id": "ARBA00059965", "url": "https://www.uniprot.org/uniprotkb/ARBA00059965#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAF12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73", "locus": { "chromosome": "2", "start_pos": 124834094, "end_pos": 124810168, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026660", "url": "https://www.ensembl.org/id/ENSBTAG00000026660" } ] } } ], "crossref": [ { "id": "A0AAA9SY73", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SY73", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07981", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07981", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12264:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12264:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03847", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03847", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASHFTGLTAVADVIKDLDTQIALIGLGPHSSKKKQDLDKLYELKSKARQIMNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGTGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQVRSLQSPKLTKEAL", "length": 216, "header": "tr|A0AAA9SY73-1|A0AAA9SY73_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 12 OS=Bos taurus OX=9913 GN=TAF12 PE=3 SV=2 CANONICAL=A0AAA9SY73-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SY73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73/entry#A0AAA9SY73-1", "sequence": { "sequence": "MAASHFTGLTAVADVIKDLDTQIALIGLGPHSSKKKQDLDKLYELKSKARQIMNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGTGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQVRSLQSPKLTKEAL", "length": 216, "header": "tr|A0AAA9SY73-1|A0AAA9SY73_BOVIN Isoform 1 of Transcription initiation factor TFIID subunit 12 OS=Bos taurus OX=9913 GN=TAF12 PE=3 SV=2 CANONICAL=A0AAA9SY73-1" }, "locus": { "chromosome": "2", "start_pos": 124833073, "end_pos": 124821743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112801.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112801.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091413.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091413.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "transcription factor TFIID complex", "id": "GO:0005669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ], "pmid": "" }, { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SY73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SY73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY73" }, { "id": "PF03847", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03847" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transcription initiation factor TFIID subunit 12", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 178, "start_aa": "Thr", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 63, "end_pos": 65 }, { "start_pos": 66, "end_pos": 68 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0G1-1", "uniprot_ac": "A0AAA9T0G1", "uniprot_id": "A0AAA9T0G1_BOVIN", "mass": { "chemical_mass": 34176.0, "monoisotopic_mass": 34176.0 }, "refseq": {}, "gene_names": [ { "name": "HUS1", "type": "recommended", "evidence": [ { "id": "A0AAA9T0G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ] } ], "protein_names": [ { "name": "Checkpoint protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T0G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SX76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX76#function" }, { "database": "UniProtKB", "id": "ARBA00055414", "url": "https://www.uniprot.org/uniprotkb/ARBA00055414#function" }, { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1#function" }, { "database": "UniProtKB", "id": "A0AAA9SCV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCV5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HUS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1", "locus": { "chromosome": "4", "start_pos": 74588333, "end_pos": 74573977, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013226", "url": "https://www.ensembl.org/id/ENSBTAG00000013226" } ] } } ], "crossref": [ { "id": "A0AAA9T0G1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0G1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013226", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013226", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514142", "url": "https://www.ncbi.nlm.nih.gov/gene/514142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016580", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016580", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12900", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12900", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12900:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12900:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SCV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1T7", "url": "https://www.uniprot.org/uniprotkb/F1N1T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1T7-1", "url": "https://www.uniprot.org/uniprotkb/F1N1T7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFRAKIVDTACLNHFTRVSNMIAKLAKTCTLRISPDKLNFILSDRVANGGVSMWCELEQENFFSEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTVPDADVSIYLPVLKTMKSVVEKMKNISNHLIIEANLNGELNLKIETELVCVTTHFKDLGNPPLASENASQDRNLEQMAEVHIDIRKLLQFLAGQQVNPTKATCRPTELPLGSTLGGHIYCGLVCRASHVESGCSLNSMNDDHRSAAHVQLTLQQVSL", "length": 307, "header": "tr|A0AAA9T0G1-1|A0AAA9T0G1_BOVIN Isoform 1 of Checkpoint protein OS=Bos taurus OX=9913 GN=HUS1 PE=3 SV=1 CANONICAL=A0AAA9T0G1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1/entry#A0AAA9SCV5-1", "sequence": { "sequence": "MKFRAKIVDTACLNHFTRVSNMIAKLAKTCTLRISPDKLNFILSDRVANGGVSMWCELEQENFFSEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTVPDADVSIYLPVLKTMKSVVEKMKNISNHLIIEANLNGELNLKIETELVCVTTHFKDLGNPPLASENASQDRNLEQMAEVHIDIRKLLQFLAGQQVNPTKATCNIVKNKIVHFDLLHEDVSLQYFIPALS", "length": 280, "header": "tr|A0AAA9SCV5-1|A0AAA9T0G1_BOVIN Computationally mapped isoform of Checkpoint protein OS=Bos taurus OX=9913 GN=HUS1 PE=3 SV=2 CANONICAL=A0AAA9T0G1-1" }, "locus": { "chromosome": "4", "start_pos": 74586241, "end_pos": 74574109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099487.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099487.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080131.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080131.2" } ] } }, { "isoform_ac": "A0AAA9SX76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1/entry#A0AAA9SX76-1", "sequence": { "sequence": "MKFRAKIVDTACLNHFTRVSNMIAKLAKTCTLRISPDKLNFILSDRVANGGVSMWCELEQENFFSEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTVPDADVSIYLPVLKTMKSVVEKMKNISNHLIIEANLNGELNLKIETELVCVTTHFKDLGNPPLGLGREHIMELSHLLLHCGGKVNLLDVRSWSVGLRASSFLICKT", "length": 256, "header": "tr|A0AAA9SX76-1|A0AAA9SX76_BOVIN Computationally mapped isoform of Checkpoint protein OS=Bos taurus OX=9913 GN=HUS1 PE=3 SV=1 CANONICAL=A0AAA9T0G1-1" }, "locus": { "chromosome": "4", "start_pos": 74582493, "end_pos": 74574109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091059.1" } ] } }, { "isoform_ac": "A0AAA9T0G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1/entry#A0AAA9T0G1-1", "sequence": { "sequence": "MKFRAKIVDTACLNHFTRVSNMIAKLAKTCTLRISPDKLNFILSDRVANGGVSMWCELEQENFFSEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTVPDADVSIYLPVLKTMKSVVEKMKNISNHLIIEANLNGELNLKIETELVCVTTHFKDLGNPPLASENASQDRNLEQMAEVHIDIRKLLQFLAGQQVNPTKATCRPTELPLGSTLGGHIYCGLVCRASHVESGCSLNSMNDDHRSAAHVQLTLQQVSL", "length": 307, "header": "tr|A0AAA9T0G1-1|A0AAA9T0G1_BOVIN Isoform 1 of Checkpoint protein OS=Bos taurus OX=9913 GN=HUS1 PE=3 SV=1 CANONICAL=A0AAA9T0G1-1" }, "locus": { "chromosome": "4", "start_pos": 74587954, "end_pos": 74574109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096176.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096176.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091187.1" } ] } }, { "isoform_ac": "F1N1T7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1/entry#F1N1T7-1", "sequence": { "sequence": "MKFRAKIVDTACLNHFTRVSNMIAKLAKTCTLRISPDKLNFILSDRVANGGVSMWCELEQENFFSEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSIELLSVSSSSRVVTHDIPVKVIPRKLWKDLQEPTVPDADVSIYLPVLKTMKSVVEKMKNISNHLIL", "length": 182, "header": "tr|F1N1T7-1|A0AAA9T0G1_BOVIN Computationally mapped isoform of Checkpoint protein OS=Bos taurus OX=9913 GN=HUS1 PE=3 SV=1 CANONICAL=A0AAA9T0G1-1" }, "locus": { "chromosome": "4", "start_pos": 74586167, "end_pos": 74574109, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033617.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033617.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033527.3", "url": "https://www.ensembl.org/id/ENSBTAP00000033527.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" }, { "name": "checkpoint clamp complex", "id": "GO:0030896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030896", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA metabolic process", "id": "GO:0006259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" }, { "name": "response to radiation", "id": "GO:0009314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9SYE9-1", "uniprot_ac": "A0AAA9SYE9", "uniprot_id": "A0AAA9SYE9_BOVIN", "mass": { "chemical_mass": 39415.0, "monoisotopic_mass": 39415.0 }, "refseq": {}, "gene_names": [ { "name": "CYSLTR2", "type": "recommended", "evidence": [ { "id": "A0AAA9SYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9" } ] } ], "protein_names": [ { "name": "Cysteinyl leukotriene receptor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9SYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYSLTR2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9", "locus": { "chromosome": "12", "start_pos": 18473564, "end_pos": 18428912, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017508", "url": "https://www.ensembl.org/id/ENSBTAG00000017508" } ] } } ], "crossref": [ { "id": "A0AAA9SYE9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9SYE9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15157", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15157", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013311", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013311", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24231:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24231:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERKLVSLSPSISASEMETNSTFSDHHSNRNCTAEDFKREFYPIVYLVIFIWGALGNGFSIYVFVQPYRKSTSVNIFMLNLATSDLLFTATLPFRVDYYLRGSNWIFGDLSCRIMSYSMYVNMYSSIYFLTVLSVVRFLATVHPFRLLHATSVRNAWIVCGIIWIFIMASSTTLLNNGSELKGNVTLCLELNRNKAPKLKTMNYIALVVGFLLPFCTLSICYMLIIRALLKAEVPELGLRLSHRKALTTIIIALVIFLLCFLPYHILRTLHLLQWTADICRDSLHKAVAITLALAAANSCFNPLLYYFAGENFKDRLKSALRKDHPQEPKCSFPFCVWLKNETRG", "length": 345, "header": "tr|A0AAA9SYE9-1|A0AAA9SYE9_BOVIN Isoform 1 of Cysteinyl leukotriene receptor 2 OS=Bos taurus OX=9913 GN=CYSLTR2 PE=4 SV=1 CANONICAL=A0AAA9SYE9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9/entry#A0AAA9SYE9-1", "sequence": { "sequence": "MERKLVSLSPSISASEMETNSTFSDHHSNRNCTAEDFKREFYPIVYLVIFIWGALGNGFSIYVFVQPYRKSTSVNIFMLNLATSDLLFTATLPFRVDYYLRGSNWIFGDLSCRIMSYSMYVNMYSSIYFLTVLSVVRFLATVHPFRLLHATSVRNAWIVCGIIWIFIMASSTTLLNNGSELKGNVTLCLELNRNKAPKLKTMNYIALVVGFLLPFCTLSICYMLIIRALLKAEVPELGLRLSHRKALTTIIIALVIFLLCFLPYHILRTLHLLQWTADICRDSLHKAVAITLALAAANSCFNPLLYYFAGENFKDRLKSALRKDHPQEPKCSFPFCVWLKNETRG", "length": 345, "header": "tr|A0AAA9SYE9-1|A0AAA9SYE9_BOVIN Isoform 1 of Cysteinyl leukotriene receptor 2 OS=Bos taurus OX=9913 GN=CYSLTR2 PE=4 SV=1 CANONICAL=A0AAA9SYE9-1" }, "locus": { "chromosome": "12", "start_pos": 18450393, "end_pos": 18449359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107785.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107785.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089117.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089117.1" } ] } }, { "isoform_ac": "A0AAA9TJI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9/entry#A0AAA9TJI8-1", "sequence": { "sequence": "MERKLVSLSPSISASEMETNSTFSDHHSNRNCTAEDFKREFYPIVYLVIFIWGALGNGFSIYVFVQPYRKSTSVNIFMLNLATSDLLFTATLPFRVDYYLRGSNWIFGDLSCRIMSYSMYVNMYSSIYFLTVLSVVRFLATVHPFRLLHATSVRNAWIVCGIIWIFIMASSTTLLNNGSELKGNVTLCLELNRNKAPKLKTMNYIALVVGFLLPFCTLSICYMLIIRALLKAEVPELGLRLSHRKALTTIIIALVIFLLCFLPYHILRTLHLLQWTADICRDSLHKAVAITLALAAANSCFNPLLYYFAGENFKDRLKSALRKDHPQEPKCSFPFCVWLKNETRGCCCC", "length": 349, "header": "tr|A0AAA9TJI8-1|A0AAA9TJI8_BOVIN Computationally mapped isoform of Cysteinyl leukotriene receptor 2 OS=Bos taurus OX=9913 GN=CYSLTR2 PE=4 SV=1 CANONICAL=A0AAA9SYE9-1" }, "locus": { "chromosome": "12", "start_pos": 18473556, "end_pos": 18449359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100393.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100393.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097324.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097324.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "leukotriene receptor activity", "id": "GO:0004974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004974", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SYE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9SYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 306, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 184, "end_pos": 186 }, { "start_pos": 20, "end_pos": 22 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 341, "end_pos": 343 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3U6-1", "uniprot_ac": "A0AAA9T3U6", "uniprot_id": "A0AAA9T3U6_BOVIN", "mass": { "chemical_mass": 62587.0, "monoisotopic_mass": 62587.0 }, "refseq": {}, "gene_names": [ { "name": "UGT1A1", "type": "recommended", "evidence": [ { "id": "A0AAA9T3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6" } ] } ], "protein_names": [ { "name": "glucuronosyltransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9T3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.17", "type": "synonym", "evidence": [ { "id": "A0AAA9T3U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UGT1A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6", "locus": { "chromosome": "3", "start_pos": 113425176, "end_pos": 113273217, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026181", "url": "https://www.ensembl.org/id/ENSBTAG00000026181" } ] } } ], "crossref": [ { "id": "A0AAA9T3U6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3U6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026181", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026181", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03784", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03784", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48043:SF161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48043:SF161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "21032", "url": "https://www.rhea-db.org/rhea/21032", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M423", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M423", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M423-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M423-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SM55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3U6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RHS8", "url": "https://www.uniprot.org/uniprotkb/F6RHS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RHS8-1", "url": "https://www.uniprot.org/uniprotkb/F6RHS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGINIGGTAPPATEHLLVCVEMALGLQLRWQVLAGLLLCLCAGRWAEAGKVLVVPMEGSHWLSMREAVRELHARGHQAVVVAPEVNLYIKADDFFTTKTYAIPYTRDEFDSIMKGRPDEFFERAHFLTWFLETMATLKNVSLFFARSCEALLYNKDLIRDLNASSFDVVLTDPVYPCGAVLAKYLSIPAVFFLRFLPCDLDVESTACPNPFSYIPRLLTMNSDHMTFFQRVKNMLYPLGLKYICQVSLTPYERMASELLQRQVSLVEILASGSVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 554, "header": "tr|A0AAA9T3U6-1|A0AAA9T3U6_BOVIN Isoform 1 of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M423-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0A3Q1M423-1", "sequence": { "sequence": "MEGSHWLSMREAVRELHTRGHQAVVVAPEVNMHIKAEDFFTTKTYAVPYTWDEFDFLGKTHIQLLFERAHFLTMLLKTMASLKNVTLLFARSCEALLYNKDLIRDLNASSFDVVLTDPVHPCGAVLAKYLSIPAVFFLRQIPCDLDVEGTACPNPFSYVPRLLTRNPDRMTFFQRVKNMLYPLALKYICLVTFTPYARMASELLQREVSLVEILASGSVWLFRGDFVMDYPRPITPNMVFIGGINCANKKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 499, "header": "tr|A0A3Q1M423-1|A0A3Q1M423_BOVIN Computationally mapped isoform of UDP-glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=2 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113332409, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076879.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076879.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064534.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064534.2" } ] } }, { "isoform_ac": "A0AAA9SLL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0AAA9SLL3-1", "sequence": { "sequence": "MEGSHWLSMREAVRELHARGHQAVVVAPEVNMHIKAEDFFTMKTYDIPYTQDKFDSLMKTHVHMLFERVHWVTMFLKTMASLKKASLLFERSCEGLLYNKDLIRHLNASSFDVVLTDPVHPCGAVLAKYLSIPAVFFLRSVPCDLDVEGTACPNPFSYVPRLLTMNPDHMTFFQRVKNMLYPLSLKYICQVTFTPYERMASELLQRDVSLVEILASGSVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 499, "header": "tr|A0AAA9SLL3-1|A0AAA9T3U6_BOVIN Computationally mapped isoform of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113336913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092873.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092873.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083544.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083544.1" } ] } }, { "isoform_ac": "A0AAA9SM55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0AAA9SM55-1", "sequence": { "sequence": "MALGLQLRRQVLAGLLLCLCVGRWAEAGKVLVAPMEGSHWLSMREAVRELHARGHQAVVVAPEVNVRVKAEDFFIKKTYAIPYTQDDFNYFLMGSFNTFFERVNFLTMFWKTIEATKNASVVFARSCEALLYNKDLIRDLNASSFDVVLTDPVYPCGAVLAKYLSIPAVFFLRFLPCDLDVEGAACPNPFSYVPKFLTRNSDHMTFFQRVKNMLYPLTLKYLCHFSFAPYAHMASELLQRDVSLGEIFGSASVWLFRGDFVMDYPRPIMPNMVFIGGINCGNRKQLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 533, "header": "tr|A0AAA9SM55-1|A0AAA9T3U6_BOVIN Computationally mapped isoform of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113372417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100235.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100235.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087440.1" } ] } }, { "isoform_ac": "A0AAA9T3U6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0AAA9T3U6-1", "sequence": { "sequence": "MGINIGGTAPPATEHLLVCVEMALGLQLRWQVLAGLLLCLCAGRWAEAGKVLVVPMEGSHWLSMREAVRELHARGHQAVVVAPEVNLYIKADDFFTTKTYAIPYTRDEFDSIMKGRPDEFFERAHFLTWFLETMATLKNVSLFFARSCEALLYNKDLIRDLNASSFDVVLTDPVYPCGAVLAKYLSIPAVFFLRFLPCDLDVESTACPNPFSYIPRLLTMNSDHMTFFQRVKNMLYPLGLKYICQVSLTPYERMASELLQRQVSLVEILASGSVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 554, "header": "tr|A0AAA9T3U6-1|A0AAA9T3U6_BOVIN Isoform 1 of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113367140, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110002.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110002.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090368.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090368.1" } ] } }, { "isoform_ac": "A0AAA9T4Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0AAA9T4Q6-1", "sequence": { "sequence": "MRTNIGGTAPPATEHLLVCAEMALGLQLRQQVLAGLLLCLCTRRWAEAGKVLVVPMEGSHWLSMREAVRELHARGHQAVVVAPEVNMHIKAEDFFTMKTYDIPYTQDKFDSLMKTHVHMLFERVHWVTMFLKTMASLKKASLLFERSCEGLLYNKDLIRHLNASSFDVVLTDPVHPCGAVLAKYLSIPAVFFLRSVPCDLDVEGTACPNPFSYVPRLLTMNPDHMTFFQRVKNMLYPLSLKYICQVTFTPYERMASELLQRDVSLVEILASGSVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 554, "header": "tr|A0AAA9T4Q6-1|A0AAA9T4Q6_BOVIN Computationally mapped isoform of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113336748, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094085.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094085.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091490.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091490.1" } ] } }, { "isoform_ac": "A0AAA9T6C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U6/entry#A0AAA9T6C7-1", "sequence": { "sequence": "MEGSHWLSMREAVRELHARGHQAVVVAPEVNMHIKAEDFFTMKTYDIPYTQDKFDSLMKTHVHMLFERVHWVTMFLKTMASLKKASLLFERSCEGLLYNKDLIRHLNASSFDVVLTDPVHPCGAVLAKYLSIPAVFFLRSVPCDLDVEGTACPNPFSYVPRLLTMNPDHMTFFQRVKNMLYPLSLKYICQVTFTPYARMASELLQREVSLVEILASGSVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEQKAMEIADALGKIPQTVLWRYTGTPPPNLAKNTKLVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMSSEDLEKALKAVINEKTYKENIMRLSRLHKDRPIEPLDLAVFWVEFVMRHKGASHLRPAAHDLTWYQYHSLDVIGFLLAVTLTVIFITFKACAFAFRKCFGKKERVKKSHKSKTH", "length": 499, "header": "tr|A0AAA9T6C7-1|A0AAA9T3U6_BOVIN Computationally mapped isoform of glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT1A1 PE=1 SV=1 CANONICAL=A0AAA9T3U6-1" }, "locus": { "chromosome": "3", "start_pos": 113424527, "end_pos": 113336913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110004.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110004.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094319.1", "url": 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"categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LF59", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF59-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMK1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMK1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1N0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLRTSSPVFLREHPRRAASLGRSQSGGRRVRAKGSTEGLQAAFGPAAAAATVWCPVTEKPAVDSVMMPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQTLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEIAVFASRAGPGVCWHPSCFVCFTCSELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGANFVSEEFWKGRVEHETPEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEMDIRASEHWIADNMVKNKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGASGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIETEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCPEKVLPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYENIEIRQPPMSERTRRRVYHFEERGPRSHYHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYTHATSDYALQNPGGPRFLGLYGEDDDSWCSSSTSSSSDSEEEGYFLGQPIPQPRPQRYAYYTDDLSSPTSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "length": 900, "header": "tr|A0AAA9T1N0-1|A0AAA9T1N0_BOVIN Isoform 1 of Prickle planar cell polarity protein 1 OS=Bos taurus OX=9913 GN=PRICKLE1 PE=3 SV=1 CANONICAL=A0AAA9T1N0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0/entry#A0A3Q1LF59-1", "sequence": { "sequence": "MERADRAATVWCPVTEKPAVDSVMMPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQTLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEIAVFASRAGPGVCWHPSCFVCFTCSELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGANFVSEEFWKGRVEHETPEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEMDIRASEHWIADNMVKNKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGASGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIETEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCPEKVLPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYENIEIRQPPMSERTRRRVYHFEERGPRSHYHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYTHATSDYALQNPGGPRFLGLYGEDDDSWCSSSTSSSSDSEEEGYFLGQPIPQPRPQRYAYYTDDLSSPTSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "length": 857, "header": "tr|A0A3Q1LF59-1|A0AAA9T1N0_BOVIN Computationally mapped isoform of Prickle planar cell polarity protein 1 OS=Bos taurus OX=9913 GN=PRICKLE1 PE=3 SV=2 CANONICAL=A0AAA9T1N0-1" }, "locus": { "chromosome": "5", "start_pos": 38170223, "end_pos": 38149418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084935.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084935.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056710.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056710.2" } ] } }, { "isoform_ac": "A0A3Q1LMK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0/entry#A0A3Q1LMK1-1", "sequence": { "sequence": "MYKLNGGLPGKYRKGQRAHGLMSLIAAATVWCPVTEKPAVDSVMMPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQTLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEIAVFASRAGPGVCWHPSCFVCFTCSELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGANFVSEEFWKGRVEHETPEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEMDIRASEHWIADNMVKNKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGASGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIETEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCPEKVLPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYENIEIRQPPMSERTRRRVYHFEERGPRSHYHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYTHATSDYALQNPGGPRFLGLYGEDDDSWCSSSTSSSSDSEEEGYFLGQPIPQPRPQRYAYYTDDLSSPTSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "length": 877, "header": "tr|A0A3Q1LMK1-1|A0AAA9T1N0_BOVIN Computationally mapped isoform of Prickle planar cell polarity protein 1 OS=Bos taurus OX=9913 GN=PRICKLE1 PE=3 SV=2 CANONICAL=A0AAA9T1N0-1" }, "locus": { "chromosome": "5", "start_pos": 38170223, "end_pos": 38151489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061102.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061102.2" } ] } }, { "isoform_ac": "A0AAA9T1N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0/entry#A0AAA9T1N0-1", "sequence": { "sequence": "MTLRTSSPVFLREHPRRAASLGRSQSGGRRVRAKGSTEGLQAAFGPAAAAATVWCPVTEKPAVDSVMMPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQTLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEIAVFASRAGPGVCWHPSCFVCFTCSELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGANFVSEEFWKGRVEHETPEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEMDIRASEHWIADNMVKNKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGASGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIETEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCPEKVLPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYENIEIRQPPMSERTRRRVYHFEERGPRSHYHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYTHATSDYALQNPGGPRFLGLYGEDDDSWCSSSTSSSSDSEEEGYFLGQPIPQPRPQRYAYYTDDLSSPTSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "length": 900, "header": "tr|A0AAA9T1N0-1|A0AAA9T1N0_BOVIN Isoform 1 of Prickle planar cell polarity protein 1 OS=Bos taurus OX=9913 GN=PRICKLE1 PE=3 SV=1 CANONICAL=A0AAA9T1N0-1" }, "locus": { "chromosome": "5", "start_pos": 38170223, "end_pos": 38150149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100579.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100579.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090482.1" } ] } }, { "isoform_ac": "A0AAF6DLQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N0/entry#A0AAF6DLQ2-1", "sequence": { "sequence": "MMPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQTLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEIAVFASRAGPGVCWHPSCFVCFTCSELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGANFVSEEFWKGRVEHETPEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEMDIRASEHWIADNMVKNKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGASGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIETEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCPEKVLPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYENIEIRQPPMSERTRRRVYHFEERGPRSHYHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYTHATSDYALQNPGGPRFLGLYGEDDDSWCSSSTSSSSDSEEEGYFLGQPIPQPRPQRYAYYTDDLSSPTSALPTPQFGQRTTKSKKKKGHKGKNCIIS", "length": 834, "header": "tr|A0AAF6DLQ2-1|A0AAF6DLQ2_BOVIN Computationally mapped isoform of Prickle planar cell polarity protein 1 OS=Bos taurus OX=9913 GN=PRICKLE1 PE=3 SV=1 CANONICAL=A0AAA9T1N0-1" }, "locus": { "chromosome": "5", "start_pos": 38170223, "end_pos": 38159949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011340.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011340.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011340.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011340.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7ICD8-1", "protein_name": "Prickle-like protein 1", "gene_name": "Prickle1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDMHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLNGNADDTLSRKLDDLSLSRQGAGFANEEFWKARVDQEASEDPEEWAEHEDYMTQLLLKFGDKSLFQQQPSEVDIRASEHWIPDSVVKSKPEVKPNHQGLVSKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEMEADDCEKMSNMGTLNSSMLHRSAESLKSLNSELCPEKVMPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDMEIRQPPLSERTRRRVYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSPKDRFRLYTPDNYEKFIQNKGARELQAYMQNADLYGQYAHATSDYALQNPGMNRFLGLYGDDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPTSALPTAQFSQRTTKSKKKKGHKGKNCIIS", "length": 831 }, "evidence": [ { "id": "A0AAA9T1N0", "url": "https://omabrowser.org/oma/group/A0AAA9T1N0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1P3B6-1", "protein_name": "Prickle planar cell polarity protein 1", "gene_name": "PRICKLE1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPKANNLVFACQRSSTSDDDSGCALEEYAWVPPGLRPEQVQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQMFSSQRKKEALGRGTIKLLSRAVMHAVCEQCGTKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCSCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATETCFSCAQCKTSLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSIRMGKSSRSADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDLSLSRQEASFVNEDFWKGRVEQEMPEDPEEWAEHEDYMTQLLLKFGDKSLFQQPAEVEIRSSEHWISDSMVKSKLDLKKNNPSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRKIQELDMEHGASGYKHDQTPWYGGSLECLSDLKQQEQSVRDSMDSLALSNITGASMDGEGKPRQSLYSLQTFQELEVEDCEKMSNMGTLNSSMLHRSTESLKSLSSELCQEKALPEEKPAHMPVLRRSKSQSRPQQVKFSDDVIDNGSYENVEIRQPPMSERTRRRVYHFEERGNRPSHHRRRSRKSRSDNALNLVTERRYSPKERFRYYSPQDHEKFIQNKSSREFRAYIQNAELYGQYAHTSSDYALRNQAVDKFFGLYGEEDDSWCSTSSSSSDSEEEGYFLGQPIPQPRSLRYPYYTDDLSGPTTALSSSQFGQRTTKSKKKKRGHKGKNCIIS", "length": 828 }, "evidence": [ { "id": "A0AAA9T1N0", "url": "https://omabrowser.org/oma/group/A0AAA9T1N0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1Q6J9-1", "protein_name": "Prickle-like protein 1a isoform X1", "gene_name": "prickle1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELENRGGLHMGSKVNKLTLGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVALYFSCLPEDKVPYVNSPGEKQRIKQLLYQLPPHDNEVRYCQSLSEEEKKELHMFSIQRKKEALGRGTLKILPRTVHHAACEHCGERLGGGEMAVCVSRAAAAGQCWHPACFTCSTCSELLVDLIYFYHDGKVHCGRHHAELLKPRCSSCDEIIFADECTEAEGRHWHMKHFSCSECEVILGGQRYIMKDGRPFCCGCFQSLYAEYCQACAQHIGVDHAQMTYDGLHWHATDACFSCAQCKSSLLGCPFLPRQGRIYCSKACSLGEDVQASDSSDSAFQSARSRESRRSVKMGKSSRSADQCRQSLLFSPASNYKFPGLSGNADDTLSKRLSQLNFADNHFWRNREDQEAPEDHEEWAEHDDYMTQLLLKFGEHGMFQDTRTDLSIWTDSELKNKTGSGGNSSLASKKYKADMYWTQSQDGLGDSAYGSHPGPASSRKLQDLDLEHGASFKHEDNKQWFNDSLECITDQLKEADLNIRDSMDSLALSNITGASVDGDIKDKPLLFSLQKFSDLDRCENTSNMGTLNSSMKSLTSDLDRTQVIEEQQEQGVPSPEVHPKPPRLPVLRRSKSQSKTQQVKFSDDVIDNGRYDELKVRQPPMSERTRRRAFQFDEQDHQRPRHHHRRRRSRMSRSDNALHLAPKEEKPRVCFKDDRRKHGLGHNGAQYGDGLRTERFTRLYEDDWCSTCSSSSSESEEEGFFLGQPIPQPRQPRYQYYASDEAAFGTRTKSKQKRGRKGKNCIIS", "length": 793 }, "evidence": [ { "id": "A0AAA9T1N0", "url": "https://omabrowser.org/oma/group/A0AAA9T1N0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3U5C7-1", "protein_name": "Prickle-like protein 1", "gene_name": "Prickle1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLEMEPKMSKLVFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLQMNGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDVSLASRQGAGFANEEFWKARVEQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQQSSEVDPRASEHWIPDNMVTNKPEVKPNHQGLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYTHDQSQWYEDSLECLSDLKPEQSIRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLQSLNSGLCPEKILPEEKPAHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRAYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQNKSARELQAYMQNANLYSQYAHATSDYALQNPGMNRFLGLCGEDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFTQRTTKSKKKKGHKGKNCIIS", "length": 832 }, "evidence": [ { "id": "A0AAA9T1N0", "url": "https://omabrowser.org/oma/group/A0AAA9T1N0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q71QF9-1", "protein_name": "Prickle-like protein 1", "gene_name": "Prickle1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAMMHAVCEQCGLQMNGGEVAVFASRAGPGVCWRPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDIHASDSSDSAFQSARSRDSRRSVRMGRSSRSADQCRQSLLLSPALNYKFPGLSGSADDTLSRKLDDVSLSGQGAGFAHEEFWKARVDQEASEDPEEWAEHEDYMTQLLLKFGDKNLFQQPPSEVDMRASEHWIPDNMVTNKPEAKQNHQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELDLDHGAAGYNHDQTQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGESKPRPSLYSLQNFEEIEAEDCEKMSNMGTLNSSMLHRSAESLKSLNSELCPEKIIPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGSYDIEIRQPPMSERTRRRVYHFEERGSRPHHHRHRRSRKSRSDNALNLVTERKYSAKDRLRLYTPDNYEKFIQSKGARELQAYMQNANLYGQYAHTTSDYALQNPGMTRFLGLYGDDDDSWCSSSTSSSDSEEEGYFLGQPIPQPRPQRFTYYTDDLSSPASALPTPQFNQRTTKSKKKKGHRGKNCIIS", "length": 831 }, "evidence": [ { "id": "A0AAA9T1N0", "url": "https://omabrowser.org/oma/group/A0AAA9T1N0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96MT3-1", "protein_name": "Prickle-like protein 1", "gene_name": "PRICKLE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4I0-1", "uniprot_ac": "A0AAA9T4I0", "uniprot_id": "A0AAA9T4I0_BOVIN", "mass": { "chemical_mass": 39123.0, "monoisotopic_mass": 39123.0 }, "refseq": { "ac": "XP_010815341", "name": "endophilin-A3 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815341" }, "gene_names": [ { "name": "SH3GL3", "type": "recommended", "evidence": [ { "id": "A0AAA9T4I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ] }, { "name": "SH3GL3", "type": "synonym", "evidence": [ { "id": "XP_010815341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815341" } ] } ], "protein_names": [ { "name": "SH3 domain containing GRB2 like 3, endophilin A3", "type": "synonym", "evidence": [ { "id": "A0AAA9T4I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#names_and_taxonomy" } ] }, { "name": "endophilin-A3 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_010815341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815341" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SH3GL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0", "locus": { "chromosome": "21", "start_pos": 24497953, "end_pos": 24665252, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018004", "url": "https://www.ensembl.org/id/ENSBTAG00000018004" } ] } } ], "crossref": [ { "id": "A0AAA9T4I0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4I0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018004", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018004", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07615", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07615", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11803", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11803", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520311", "url": "https://www.ncbi.nlm.nih.gov/gene/520311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NFLENDX", "url": "https://omabrowser.org/oma/group/NFLENDX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFQ9", "url": "https://www.orthodb.org/?gene=A0A3Q1LFQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MX23", "url": "https://www.orthodb.org/?gene=F1MX23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807004", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807004", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": 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"A0AAA9SU57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX23", "url": "https://www.uniprot.org/uniprotkb/F1MX23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX23-1", "url": "https://www.uniprot.org/uniprotkb/F1MX23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVAGLKKQFHKASQLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 347, "header": "tr|A0AAA9T4I0-1|A0AAA9T4I0_BOVIN Isoform 1 of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=1 CANONICAL=A0AAA9T4I0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#A0A3Q1LFQ9-1", "sequence": { "sequence": "MLLKHFPGIGSRWSILRDLGTEPCFTDGEAETWLYRLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 368, "header": "tr|A0A3Q1LFQ9-1|A0AAA9T4I0_BOVIN Computationally mapped isoform of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=2 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24641896, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068877.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068877.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057059.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057059.2" } ] } }, { "isoform_ac": "A0AAA9S1D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#A0AAA9S1D0-1", "sequence": { "sequence": "MQLSAHLMLLKHFPGIGSRWSILRDLGTEPCFTDGEAETWLYRLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 375, "header": "tr|A0AAA9S1D0-1|A0AAA9T4I0_BOVIN Computationally mapped isoform of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=1 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24664786, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099727.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099727.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079682.1" } ] } }, { "isoform_ac": "A0AAA9SU57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#A0AAA9SU57-1", "sequence": { "sequence": "MGDRSHRDGENEALWVSVFIAHLMLLKHFPGIGSRWSILRDLGTEPCFTDGEAETWLYRVKYIMRNAGLEEAQVGIKIAGRNINNLRYADDTTLMAESEEELKSLLMKLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 440, "header": "tr|A0AAA9SU57-1|A0AAA9T4I0_BOVIN Computationally mapped isoform of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=2 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24665053, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118281.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118281.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088865.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088865.2" } ] } }, { "isoform_ac": "A0AAA9T4I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#A0AAA9T4I0-1", "sequence": { "sequence": "MSVAGLKKQFHKASQLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 347, "header": "tr|A0AAA9T4I0-1|A0AAA9T4I0_BOVIN Isoform 1 of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=1 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24614322, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098249.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098249.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091416.1" } ] } }, { "isoform_ac": "A0AAA9TZB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#A0AAA9TZB8-1", "sequence": { "sequence": "MGDRSHRDGENEALWVSVFIAHLMLLKHFPGIGSRWSILRDLGTEPCFTDGEAETWLYRLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 391, "header": "tr|A0AAA9TZB8-1|A0AAA9TZB8_BOVIN Computationally mapped isoform of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=1 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24665053, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110123.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110123.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102593.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102593.1" } ] } }, { "isoform_ac": "F1MX23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0/entry#F1MX23-1", "sequence": { "sequence": "MQLSASQASLSVGFSNQEYWSRKLYPPPGDLPNPAHLMLLKHFPGIGSRWSILRDLGTEPCFTDGEAETWLYRLFSEKISGVEGTKLDDEFLDMERKIDITNKAVAEILSKATEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEGSTFGSALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLQMRISAASNVPKREYKPRPIKRSPSELNGVSTASSAKTTGSNVPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGILHGESGFFPINYVEVIVPLPQ", "length": 405, "header": "tr|F1MX23-1|F1MX23_BOVIN Computationally mapped isoform of SH3 domain containing GRB2 like 3, endophilin A3 OS=Bos taurus OX=9913 GN=SH3GL3 PE=3 SV=4 CANONICAL=A0AAA9T4I0-1" }, "locus": { "chromosome": "21", "start_pos": 24664786, "end_pos": 24508839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023954.8", "url": "https://www.ensembl.org/id/ENSBTAT00000023954.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023954.7", "url": "https://www.ensembl.org/id/ENSBTAP00000023954.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-182971", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "resource": "Reactome", "description": "EGFR downregulation" }, { "id": "R-BTA-6807004", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807004", "resource": "Reactome", "description": "Negative regulation of MET activity" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NB17-1", "protein_name": "SH3 domain containing GRB2 like 3, endophilin A3", "gene_name": "SH3GL3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFQEMERKIDVTNKAVAELLSKSTEYLQPNPAYRAKLGMLNTMSKIRGQVKTTGYPQTEGLLGDCMIRYGRELGDDSMFGLALLDAGESMKQMAEVKDSLDINVKQNFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRLGKIPDEEVKQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHKQSTEILEDLQSKLQNRINVASSRPKREFKPKPVITTTLETGDNQQHNGIAYSSSIKSSGSSMHVDQPCCQALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLNGESGFFPINYVEVMVPLPQ", "length": 353 }, "evidence": [ { "id": "A0AAA9T4I0", "url": 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"MSVAGLKKQFHKASQLFSEKISGAEGTKLDEEFLNMEKKIDITSKAVAEILSKATEYLQPNPAYRAKLGMLNTVSKLRGQVKATGYPQTEGLLGDCMLKYGKELGEDSAFGNSLVDVGEALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLRKLEGRRLDYDYKKRRVGKIPEEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFVEAALDYHRQSTEILQELQSKLELRISLASKVPKREFMPKPVNMSSTDANGVGPSSSSKTPGTDTPADQPCCRGLYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLRGESGFFPINYVEVIVPLPP", "length": 347 }, "evidence": [ { "id": "A0AAA9T4I0", "url": "https://omabrowser.org/oma/group/A0AAA9T4I0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99963-1", "protein_name": "Endophilin-A3", "gene_name": "SH3GL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"database": "UniProtKB", "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ], "pmid": "" }, { "name": "membrane organization", "id": "GO:0061024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I0" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": 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"url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22946", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22946", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LHJ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUD3", "url": "https://www.uniprot.org/uniprotkb/F1MUD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUD3-1", "url": "https://www.uniprot.org/uniprotkb/F1MUD3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEILCQWLNQELKVSQTVSPKSFAKAFSSGYLIGEVLHKFALQDDFADFSESRISSAKLNNFSRLEPTLHLLGVQFDQNVAHNIITEKPGAATKLLYQLYIALQRKKKGVQTGVEMPTVQPLMSTKVQNMKSEAFRDQRLSRRRQNEIMAKIQAAIIQIPKPTSNRTLKTLDAQKLMKKKKEAEDVANEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQYEERRLKDFQDALDREAALARQAKIDFEEQALRDKEIHEQIAIERAQARYEKHYSICAEILDQILDLSTKVADYRLLTNNLIPYKLMHDWKELFFHGKPIYEQASLRHLPTKLSAEHLIELEKRNLLDNNDYEEYKNMVGEWALPEEMVENLPPSNNCILGHVIHRLIESSLPPQVESTVPELPSFAIKGCLLGKTFSGKTTALKALEKSFPIQVLSIDTLVQEAIQAFHDKESVSGAHGLQKAPEEKALPVRQESDEDNQDVQDGSLAEALPKKEDKTRLNTDARKAAKAEEVVASDSFSELTVRAQLGAKSERLLKKGKSISDILLVSIMVNAINQIPMYKGWILDGFPMTLNQAKLLEEALTGYNRNLIELEGKKSHTSTLAVDPTASKEVPLPPSAFDFVMLLDISDNSSLNRMNDIMAEAFSSETPLEDINQRVAAKNKDTDEDQNLRDQIQHRIVGFLDNWPSLEQWFTEPENILIKINAEVDKQSLCQKVKEMFMTEIMKKENKVKKKLEEKEAERKEEVSLTEKTSPPPPPPPPPEPEKEKEVHLPQERSKTPAAKGKQASEPPHGNREPLQEGKGKKSETSLKRKGSPRGKSLGGKIPLKKSPAESTDVSPVPVVPAPSKPGSEEWVYVNEPIPEEIPSFLVPYWKLIENSYINSIKTVLRQLREDQHAVLAYLYDIRTGFQQFLRRPDHKQDFVSQWQADFNSLPDDLWDDEETKAELHQRVNDFRDRLWDICDARKEEAEQERLDIINESWLQDSTGIAMNHFFSLMQAELNRFQDTKRLLQDYYRAMECKIPMDDTKRFTRVPLVQLDSKDILESQLRIPLVPRRSISPESALSKPKTKSILKGKIDYMLESVELNFEADEKMVMDTWQQSSLAISHMVAAEIHQRLMEEEKENQPAETKEKLPQAAANKKVKKEPPKKKKEDKKGKGKSPPMTEAAPVVLPAEETEEVEVKNELKLRIKEEHLAALQFEEIATQFRLELIKVKALAFLEELVIKAVDVYRLMEKWLGERYLNEMASVEKLTGVARYHIETSTKIQNELYLDQEDFFINGDIKVFPDPPPPVRPPPVEKEENGTLTIEQLDNLRDQFLDIAPKGRDSPDDVSGFTKKQKRPRKLDHYLPKKNNQFLKIWLKKYPWLVYDEILNLMFCGLCRKHGVTSKGNQVSFFYGTDNFRTEFLNAHHLSEPHAKASLMEATSGSPGSRATTELMVRTMSKVTLGRVENLFRSCHAIAKTGRPLKDFLWMCSLDDMKGVDIGPVFRTSKSARTFTYFIAEVERRALREKLEKSQFFSVLSDGIAASSVEEAELVYVQFARAGRVHCQIVGVQTVEKKEPRAIKHAIEKTLERNLQLRLSNQDWAKKLVGFGSDGAPGSEGENSSEVALLLREIQPGVLPVYCFAHHLELSYQAVFRNVPLYNHVKDLLHSMYCFYHDSPAHRSALLTAFKGLHLRPAMPSQVSGQRWLQGLQTALQNFLKGYPAIVQQLHSAEESRSDSSHQKAKELLESLLQADVVKFVHFLLDVVNVLSILSHVSQNRNSSIADIFATLESTLEMLQIYQTRPGPKERGVDSVTHFHGNCLGGKGNISDVRNMVLTHLIKKLRGCFRDANQDVVKATMIGSFKLWPAKINQEFGEKEVAILIAHYEPVLEAAKVKIDQVDTEWSMLKLEIYSRFQNIRKLTWDFVNSVYLHKYPNILTLIDLVLSLPASSAEAGRGFSQMKRIRSQMHAKVKADSMTDLLIIQLNSPDINNFDPRKAIHLWNTRTPSSTEDTRPNSDCSSNSESLGESD", "length": 2110, "header": "tr|A0AAA9T2E1-1|A0AAA9T2E1_BOVIN Isoform 1 of Sperm flagellar 2 OS=Bos taurus OX=9913 GN=SPEF2 PE=4 SV=1 CANONICAL=A0AAA9T2E1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1/entry#A0A3Q1LHJ4-1", "sequence": { "sequence": "MSEILCQWLNQELKVSQTVSPKSFAKAFSSGYLIGEVLHKFALQDDFADFSESSASKTSLDTAGQTTTDLLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQYEERRLKDFQDALDREAALARQAKIDFEEQALRDKEIHEQIAIERAQARYEKHYSICAEILDQILDLSTKVADYRLLTNNLIPYKLMHDWKELFFHGKPIYEQASLRHLPTKLSAEHLIELEKRNLLDNNDYEEYKNMVGEWALPEEMVENLPPSNNCILGHVIHRLIESSLPPQVESTVPELPSFAIKGCLLGKTFSGKTTALKALEKSFPIQVLSIDTLVQEAIQAFHDKESVSGAHGLQKAPEEKALPVRQESDEDNQACTSSPKDVQDGSLAEALPKKEDKTRLDTDARKAAKAEEVVASDSFSELTVRAQLGAKSERLLKKGKSISDILLVSIMVNAINQIPMYKGWILDGFPMTLNQAKLLEEALTGYNRNLIELEGKKSHTSTLAVDPTASKEVPLPPSAFDFVMLLDISDNSSLNRMNDIMAEAFSSETPLEDINQRVAAKNKDTDEDQNLRDQIQHRIVGFLDNWPSLEQWFTEPENILIKINAEVDKQSLCQKVKEMFMTEIMKKENKVKKKLEEKEAERKEEVSLTEKTSPPPPPPPPPEPEKEKEVHLPQERSKTPAAKGKQASEPPHGNREPLQEGKGKKSETSLKRKGSPRGKSLGGKIPLKKSPAESTDVSPVPVVPAPSKPGSEEWVYVNEPIPEEIPSFLVPYWKLIENSYINSIKTVLRQLREDQHAVLAYLYDIRTGFQQFLRRPDHKQDFVSQWQADFNSLPDDLWDDEETKAELHQRVNDFRDRLWDICDARKEEAEQERLDIINESWLQDSTGIAMNHFFSLMQAELNRFQDTKRLLQDYYRAMECKIPMDDTKRFTRVPLVQLDSKDILESQLRIPLVPRRSISPESALSKPKTKSILKGKIDYMLESVELNFEADEKMVMDTWQQSSLAISHMVAAEIHQRLMEEEKENQPAETKEKLPQAAANKKVKKEPPPPPPPPKKKKEDKKGKGKSPPMTEAAPVVLPAEETEEVEVKNELKLRIKEEHLAALQFEEIATQFRLELIKVKALAFLEELVIKAVDVYRLMEKWLGERYLNEMASVEKLTGVARYHIETSTKIQNELYLDQEDFFINGDIKVFPDPPPPVRPPPVEKEENGTLTIEQLDNLRDQFLDIAPKGIIGNKAFADLLLDLVTLNLGTNNFPSSWMNLTQPELQELASLLVTNSESVDWRKFLLVVALPWPIPLEEELLETLQRFKALDAEQLGTITYEQYKQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADCEKDPPQLDYTQMLLYFACHPDSTEGVYRALSVAIGTHVFQPIEMPHPVAEKTSSFTDMSPIEEYPELEDNFMSEERELQEDGEEKEEEIPENANTEMISMQTLLQVFRGGNEVLDANRFASHQKLENTYLENFIKVFQDLGSKNLEPIEVAVLLKHPFIQDLISSYPDYKIPDVKIILQRSEHVQGSDEERSPSRLTEEKK", "length": 1618, "header": "tr|A0A3Q1LHJ4-1|A0AAA9T2E1_BOVIN Computationally mapped isoform of Sperm flagellar 2 OS=Bos taurus OX=9913 GN=SPEF2 PE=4 SV=1 CANONICAL=A0AAA9T2E1-1" }, "locus": { "chromosome": "20", "start_pos": 38571999, "end_pos": 38369658, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079607.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079607.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058220.1" } ] } }, { "isoform_ac": "A0AAA9T2E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1/entry#A0AAA9T2E1-1", "sequence": { "sequence": "MSEILCQWLNQELKVSQTVSPKSFAKAFSSGYLIGEVLHKFALQDDFADFSESRISSAKLNNFSRLEPTLHLLGVQFDQNVAHNIITEKPGAATKLLYQLYIALQRKKKGVQTGVEMPTVQPLMSTKVQNMKSEAFRDQRLSRRRQNEIMAKIQAAIIQIPKPTSNRTLKTLDAQKLMKKKKEAEDVANEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQYEERRLKDFQDALDREAALARQAKIDFEEQALRDKEIHEQIAIERAQARYEKHYSICAEILDQILDLSTKVADYRLLTNNLIPYKLMHDWKELFFHGKPIYEQASLRHLPTKLSAEHLIELEKRNLLDNNDYEEYKNMVGEWALPEEMVENLPPSNNCILGHVIHRLIESSLPPQVESTVPELPSFAIKGCLLGKTFSGKTTALKALEKSFPIQVLSIDTLVQEAIQAFHDKESVSGAHGLQKAPEEKALPVRQESDEDNQDVQDGSLAEALPKKEDKTRLNTDARKAAKAEEVVASDSFSELTVRAQLGAKSERLLKKGKSISDILLVSIMVNAINQIPMYKGWILDGFPMTLNQAKLLEEALTGYNRNLIELEGKKSHTSTLAVDPTASKEVPLPPSAFDFVMLLDISDNSSLNRMNDIMAEAFSSETPLEDINQRVAAKNKDTDEDQNLRDQIQHRIVGFLDNWPSLEQWFTEPENILIKINAEVDKQSLCQKVKEMFMTEIMKKENKVKKKLEEKEAERKEEVSLTEKTSPPPPPPPPPEPEKEKEVHLPQERSKTPAAKGKQASEPPHGNREPLQEGKGKKSETSLKRKGSPRGKSLGGKIPLKKSPAESTDVSPVPVVPAPSKPGSEEWVYVNEPIPEEIPSFLVPYWKLIENSYINSIKTVLRQLREDQHAVLAYLYDIRTGFQQFLRRPDHKQDFVSQWQADFNSLPDDLWDDEETKAELHQRVNDFRDRLWDICDARKEEAEQERLDIINESWLQDSTGIAMNHFFSLMQAELNRFQDTKRLLQDYYRAMECKIPMDDTKRFTRVPLVQLDSKDILESQLRIPLVPRRSISPESALSKPKTKSILKGKIDYMLESVELNFEADEKMVMDTWQQSSLAISHMVAAEIHQRLMEEEKENQPAETKEKLPQAAANKKVKKEPPKKKKEDKKGKGKSPPMTEAAPVVLPAEETEEVEVKNELKLRIKEEHLAALQFEEIATQFRLELIKVKALAFLEELVIKAVDVYRLMEKWLGERYLNEMASVEKLTGVARYHIETSTKIQNELYLDQEDFFINGDIKVFPDPPPPVRPPPVEKEENGTLTIEQLDNLRDQFLDIAPKGRDSPDDVSGFTKKQKRPRKLDHYLPKKNNQFLKIWLKKYPWLVYDEILNLMFCGLCRKHGVTSKGNQVSFFYGTDNFRTEFLNAHHLSEPHAKASLMEATSGSPGSRATTELMVRTMSKVTLGRVENLFRSCHAIAKTGRPLKDFLWMCSLDDMKGVDIGPVFRTSKSARTFTYFIAEVERRALREKLEKSQFFSVLSDGIAASSVEEAELVYVQFARAGRVHCQIVGVQTVEKKEPRAIKHAIEKTLERNLQLRLSNQDWAKKLVGFGSDGAPGSEGENSSEVALLLREIQPGVLPVYCFAHHLELSYQAVFRNVPLYNHVKDLLHSMYCFYHDSPAHRSALLTAFKGLHLRPAMPSQVSGQRWLQGLQTALQNFLKGYPAIVQQLHSAEESRSDSSHQKAKELLESLLQADVVKFVHFLLDVVNVLSILSHVSQNRNSSIADIFATLESTLEMLQIYQTRPGPKERGVDSVTHFHGNCLGGKGNISDVRNMVLTHLIKKLRGCFRDANQDVVKATMIGSFKLWPAKINQEFGEKEVAILIAHYEPVLEAAKVKIDQVDTEWSMLKLEIYSRFQNIRKLTWDFVNSVYLHKYPNILTLIDLVLSLPASSAEAGRGFSQMKRIRSQMHAKVKADSMTDLLIIQLNSPDINNFDPRKAIHLWNTRTPSSTEDTRPNSDCSSNSESLGESD", "length": 2110, "header": "tr|A0AAA9T2E1-1|A0AAA9T2E1_BOVIN Isoform 1 of Sperm flagellar 2 OS=Bos taurus OX=9913 GN=SPEF2 PE=4 SV=1 CANONICAL=A0AAA9T2E1-1" }, "locus": { "chromosome": "20", "start_pos": 38571999, "end_pos": 38403333, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090801.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090801.1" } ] } }, { "isoform_ac": "F1MUD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1/entry#F1MUD3-1", "sequence": { "sequence": "MSEILCQWLNQELKVSQTVSPKSFAKAFSSGYLIGEVLHKFALQDDFADFSESRISSAKLNNFSRLEPTLHLLGVQFDQNVAHNIITEKPGAATKLLYQLYIALQRKKKGVQTGVEMPTVQPLMSTKVQNMKSEAFRDQRLSRRRQNEIMAKIQAAIIQIPKPTSNRTLKTLDAQKLMKKKKEAEDVANEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQYEERRLKDFQDALDREAALARQAKIDFEEQALRDKEIHEQIAIERAQARYEKHYSICAEILDQILDLSTKVADYRLLTNNLIPYKLMHDWKELFFHGKPIYEQASLRHLPTKLSAEHLIELEKRNLLDNNDYEEYKNMVGEWALPEEMVENLPPSNNCILGHVIHRLIESSLPPQVESTVPELPSFAIKGCLLGKTFSGKTTALKALEKSFPIQVLSIDTLVQEAIQAFHDKESVSGAHGLQKAPEEKALPVRQESDEDNQAIHEVISSQALPKKEDKTRLDTDARKAAKAEEVVASDSFSELTVRAQLGAKSERLLKKGKSISDILLVSIMVNAINQIPMYKGWILDGFPMTLNQAKLLEEALTGYNRNLIELEGKKSHTSTLAVDPTASKEVPLPPSAFDFVMLLDISDNSSLNRMNDIMAEAFSSETPLEDINQRVAAKNKDTDEDQNLRDQIQHRIVGFLDNWPSLEQWFTEPENILIKINAEVDKQSLCQKVKEMFMTEIMKKENKVKKKLEEKEAERKEEVSLTEKTSPPPPPPPPPEPEKEKEVHLPQERSKTPAAKGKQASEPPHGNREPLQEGKGKKSETSLKRKGSPRGKSLGGKIPLKKSPAESTDVSPVPVVPAPSKPGSEEWVYVNEPIPEEIPSFLVPYWKLIENSYINSIKTVLRQLREDQHAVLAYLYDIRTGFQQFLRRPDHKQDFVSQWQADFNSLPDDLWDDEETKAELHQRVNDFRDRLWDICDARKEEAEQERLDIINESWLQDSTGIAMNHFFSLMQAELNRFQDTKRLLQDYYRAMECKIPMDDTKRFTRVPLVQLDSKDILESQLRIPLVPRRSISPESALSKPKTKSILKGKIDYMLESVELNFEADEKMVMDTWQQSSLAISHMVAAEIHQRLMEEEKENQPAETKEKLPQAAANKKVKKEPPPPPPPPKKKKEDKKGKGKSPPMTEAAPVVLPAEETEEVEVKNELKLRIKEEHLAALQFEEIATQFRLELIKVKALAFLEELVIKAVDVYRLMEKWLGERYLNEMASVEKLTGVARYHIETSTKIQNELYLDQEDFFINGDIKVFPDPPPPVRPPPVEKEENGTLTIEQLDNLRDQFLDIAPKGIIGNKAFADLLLDLVTLNLGTNNFPSSWMNLTQPEAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADCEKDPPQLDYTQMLLYFACHPDSTEGVYRALSVAIGTHVFQPIEMPHPVAEKTSSFTDMSPIEEYPELEDNFMSEERELQEDGEEKEEEIPENANTEMISMQTLLQVFRGGNEVLDANRFASHQKLENTYLENFIKVFQDLGSKNLEPIEVAVLLKHPFIQDLISSYPDYKIPDVKIILQRSEHVQGSDEERSPSRLTEEKK", "length": 1703, "header": "tr|F1MUD3-1|A0AAA9T2E1_BOVIN Computationally mapped isoform of Sperm flagellar 2 OS=Bos taurus OX=9913 GN=SPEF2 PE=4 SV=3 CANONICAL=A0AAA9T2E1-1" }, "locus": { "chromosome": "20", "start_pos": 38571999, "end_pos": 38369658, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009967.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009967.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009967.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009967.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 704, "start_aa": "Thr", "end_pos": 704, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr704", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sperm axoneme assembly", "id": "GO:0007288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007288", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1074, "end_pos": 1076, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1399, "end_pos": 1401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1701, "end_pos": 1703, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1860, "end_pos": 1862, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1907, "end_pos": 1909, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 727, "end_pos": 729, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E1" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 105, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 704 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1074, "end_pos": 1076 }, { "start_pos": 1399, "end_pos": 1401 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 1701, "end_pos": 1703 }, { "start_pos": 1860, "end_pos": 1862 }, { "start_pos": 1907, "end_pos": 1909 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 727, "end_pos": 729 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2A7-1", "uniprot_ac": "A0AAA9T2A7", "uniprot_id": "A0AAA9T2A7_BOVIN", "mass": { "chemical_mass": 27514.0, "monoisotopic_mass": 27514.0 }, "refseq": {}, "gene_names": [ { "name": "POU2AF3", "type": "recommended", "evidence": [ { "id": "A0AAA9T2A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ] } ], "protein_names": [ { "name": "POU class 2 homeobox associating factor 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T2A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POU2AF3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7", "locus": { "chromosome": "15", "start_pos": 21581919, "end_pos": 21571351, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052702", "url": "https://www.ensembl.org/id/ENSBTAG00000052702" } ] } } ], "crossref": [ { "id": "A0AAA9T2A7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2A7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052702", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052702", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR043265", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043265", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HGYPQED", "url": "https://omabrowser.org/oma/group/HGYPQED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR36689", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36689", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36689:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36689:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIY2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIY2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTQSGGNSVHLSDPVPPSSAGLYFEPEPIPSTPNYFQPREFSSCVSCEENPGFLDQIFDSYLQPETHPDPSLSSMQSTPHYFPDSFQAAPFCFNQSLTPESPSDSSTLSGSLDYNYCPAQLPSYTAESHTALPQLDTRNCGHPSEDYTYSHPPAHAQYDSFSPASICCCASCEAERLDAFRASDCFSYPSTDYVNFAPSAAASSDLYKRETNWDICYS", "length": 250, "header": "tr|A0AAA9T2A7-1|A0AAA9T2A7_BOVIN Isoform 1 of POU class 2 homeobox associating factor 3 OS=Bos taurus OX=9913 GN=POU2AF3 PE=4 SV=1 CANONICAL=A0AAA9T2A7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7/entry#A0A3Q1LIY2-1", "sequence": { "sequence": "PWDLSAERTLRAQQRRRGELEARDEPGTRAGRPEPGRGGSCADPGPHSLPLGPRTRGGSLRETVDGGKEKPKVYQGVRVKITVKELLQQRRAHQAASGGTQSGGNSVHLSDPVPPSSAGLYFEPEPIPSTPNYFQPREFSSCVSCEENPGFLDQIFDSYLQPETHPDPSLSSMQSTPHYFPDSFQAAPFCFNQSLTPESPSDSSTLSGSLDYNYCPAQLPSYTAESHTALPQLDTRNCGHPSEDYTYSHPPAHAQYDSFSPASICCCASCEAERLDAFRASDCFSYPSTDYVNFAPSAAASSDLYKRETNWDICYS", "length": 316, "header": "tr|A0A3Q1LIY2-1|A0AAA9T2A7_BOVIN Computationally mapped isoform of POU class 2 homeobox associating factor 3 OS=Bos taurus OX=9913 GN=POU2AF3 PE=4 SV=1 CANONICAL=A0AAA9T2A7-1" }, "locus": { "chromosome": "15", "start_pos": 21581216, "end_pos": 21572017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071149.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071149.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059191.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059191.1" } ] } }, { "isoform_ac": "A0AAA9T2A7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7/entry#A0AAA9T2A7-1", "sequence": { "sequence": "MSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTQSGGNSVHLSDPVPPSSAGLYFEPEPIPSTPNYFQPREFSSCVSCEENPGFLDQIFDSYLQPETHPDPSLSSMQSTPHYFPDSFQAAPFCFNQSLTPESPSDSSTLSGSLDYNYCPAQLPSYTAESHTALPQLDTRNCGHPSEDYTYSHPPAHAQYDSFSPASICCCASCEAERLDAFRASDCFSYPSTDYVNFAPSAAASSDLYKRETNWDICYS", "length": 250, "header": "tr|A0AAA9T2A7-1|A0AAA9T2A7_BOVIN Isoform 1 of POU class 2 homeobox associating factor 3 OS=Bos taurus OX=9913 GN=POU2AF3 PE=4 SV=1 CANONICAL=A0AAA9T2A7-1" }, "locus": { "chromosome": "15", "start_pos": 21581216, "end_pos": 21571737, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093531.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093531.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091860.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AHK0-1", "protein_name": "POU class 2 homeobox associating factor 3", "gene_name": "POU2AF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTLSGGTSVHLADPDSPSPSGLYFEPEPIPSMPNYFQPREFSSCVSCEENPSCLDQIFDSYLQAETHPDPSLTSMQSTPHCFPDSFQAAPFCFNQSLTPGSPSDSSTLSGSLDCSYSPAQLPACAPENYGSPPSLDPRNCGYPSEDYLYPPLPVHAQYDCFSTAPASVCCCASCEAEHLDPLRASEYFSYPSTDCVTFAPSATAGSDFYKRETNWDTCYS", "length": 252 }, "evidence": [ { "id": "A0AAA9T2A7", "url": "https://omabrowser.org/oma/group/A0AAA9T2A7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LN29-1", "protein_name": "POU class 2 homeobox associating factor 3", "gene_name": "Pou2af3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEKPKVYQGVRVKMTVKELLQQRRAHQAASGATLTGSSSIHLPDTTMPSPAGLYFEPEPTSSTPSYFQAREFSTCVSCEENPSCLDQIFESYLQTDTPPEPLLNSAQIAPHYFPESCPVASFCHNLMPGSPSDSSSLSGSYDCSYSPAQLPAYTPENYTFPPSLDSLYSSLPEEGYFCQHWPSHPQYNHSSPTTPSSVCYYASCEAEHLDALRTTELFSYPGMDCMDFAPSAATTGDFYKRETSCDACYS", "length": 251 }, "evidence": [ { "id": "A0AAA9T2A7", "url": "https://omabrowser.org/oma/group/A0AAA9T2A7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8K830-5", "protein_name": "POU class 2 homeobox associating factor 3", "gene_name": "POU2AF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEKPKVYQGVRVKITVKELLQQRRAHQAASGGTRSGGSSVHLSDPVAPSSAGLYFEPEPISSTPNYLQRGEFSSCVSCEENSSCLDQIFDSYLQTEMHPEPLLNSTQSAPHHFPDSFQATPFCFNQSLIPGSPSNSSILSGSLDYSYSPVQLPSYAPENYNSPASLDTRTCGYPPEDHSYQHLSSHAQYSCFSSATTSICYCASCEAEDLDALQAAEYFYPSTDCVDFAPSAAATSDFYKRETNCDICYS", "length": 251 }, "evidence": [ { "id": "A0AAA9T2A7", "url": "https://omabrowser.org/oma/group/A0AAA9T2A7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F8VPY8-1", "protein_name": "POU Class 2 homeobox-associating factor 3", "gene_name": "Pou2af3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEKPKVYQGVRVKMTVKELLQQRRAHQATSGANLSGSSGLHLPDTTMPSSAGLYFEPEPTSSTPSYFQTREFSTCVSCEEIPSCLDQIFESYLQTDTLPEPLLNSAQIAPHYFPESCQVAPFCHNQSLIPGSPSDSSSLSGSFDCSYSPTQLPSYTPENYSSPPSLDSLHSSLPEEGYFCQHWPSHPQYNHSSPATPSSVCYYASCEAEHLDALRTTEFFSYSGMDCADFAPPVATTGDFYKRETSCDACYS", "length": 253 }, "evidence": [ { "id": "A0AAA9T2A7", "url": "https://omabrowser.org/oma/group/A0AAA9T2A7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" }, { "name": "POU domain binding", "id": "GO:0070974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070974", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A7" }, { "id": "PS52003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OCA", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 27, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1Y3-1", "uniprot_ac": "A0AAA9T1Y3", "uniprot_id": "A0AAA9T1Y3_BOVIN", "mass": { "chemical_mass": 94645.0, "monoisotopic_mass": 94645.0 }, "refseq": {}, "gene_names": [ { "name": "PTBP3", "type": "recommended", "evidence": [ { "id": "A0AAA9T1Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ] } ], "protein_names": [ { "name": "Polypyrimidine tract-binding protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9T1Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#names_and_taxonomy" } ] }, { "name": "Regulator of differentiation 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T1Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LLD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLD4#function" }, { "database": "UniProtKB", "id": "ARBA00055436", "url": "https://www.uniprot.org/uniprotkb/ARBA00055436#function" }, { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3#function" }, { "database": "UniProtKB", "id": "F1MPG6", "url": "https://www.uniprot.org/uniprotkb/F1MPG6#function" } ] }, { "annotation": "RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LLD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLD4#function" }, { "database": "UniProtKB", "id": "ARBA00059066", "url": "https://www.uniprot.org/uniprotkb/ARBA00059066#function" }, { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3#function" }, { "database": "UniProtKB", "id": "F1MPG6", "url": "https://www.uniprot.org/uniprotkb/F1MPG6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTBP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3", "locus": { "chromosome": "8", "start_pos": 101634404, "end_pos": 101722224, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016750", "url": "https://www.ensembl.org/id/ENSBTAG00000016750" } ] } } ], "crossref": [ { "id": "A0AAA9T1Y3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1Y3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016750", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016750", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12703", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12703", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12779", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12779", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12784", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12784", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "104968451", "url": "https://www.ncbi.nlm.nih.gov/gene/104968451", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038511", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038511", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104968451", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968451", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VIFQKSG", "url": "https://omabrowser.org/oma/group/VIFQKSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLD4", "url": "https://www.orthodb.org/?gene=A0A3Q1LLD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPG6", "url": "https://www.orthodb.org/?gene=F1MPG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04177", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13893", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13893", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22976", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22976", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LLD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLD4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPG6", "url": "https://www.uniprot.org/uniprotkb/F1MPG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPG6-1", "url": "https://www.uniprot.org/uniprotkb/F1MPG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAEDELLLPRLPELFETSKQLLDEVEIAAEPTSSQIIQDKVFKGLDLLKKAAEMLSQLDLFSQNEDLEEIASTDLKYLMVPAFQGAFTMKQVSPSKRLDHLQWAREHFLNFLTQCQYYHVAKFELPKTKTNLAGNNTANSSMAYPSIIAMASQRQAKKERYKQKKEVEHRLSALKSAVESGQADDEHVREYYLLHLRRWIGISLEEIESIDQEIKILREKDSTHEASTSQSSHQDRPPMKPFVLTQNMAQAKVFGAGYPSLASMTVNDWYEQHRKFGALPDQGIATTMSEFKRAAQQQEDQEHEEEEDDEQAVCRAREWDDWKDTHPRGYGNRQNMANGNDNKKFKGDRPLCSPSRVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSTVQSGSLALPGAPTNEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGMPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 853, "header": "tr|A0AAA9T1Y3-1|A0AAA9T1Y3_BOVIN Isoform 1 of Polypyrimidine tract-binding protein 3 OS=Bos taurus OX=9913 GN=PTBP3 PE=3 SV=1 CANONICAL=A0AAA9T1Y3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#A0A3Q1LLD4-1", "sequence": { "sequence": "MDGVVTDLIAVGLKRGSDELLSSGIINGPFTMNNSTPAGVYANGNDNKKFKGDRPLCSPSRVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSTVQSGSLALPGAPTNEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGMPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 556, "header": "tr|A0A3Q1LLD4-1|A0AAA9T1Y3_BOVIN Computationally mapped isoform of Polypyrimidine tract-binding protein 3 OS=Bos taurus OX=9913 GN=PTBP3 PE=3 SV=1 CANONICAL=A0AAA9T1Y3-1" }, "locus": { "chromosome": "8", "start_pos": 101721847, "end_pos": 101635408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080429.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080429.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057353.1" } ] } }, { "isoform_ac": "A0AAA9S8D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#A0AAA9S8D4-1", "sequence": { "sequence": "TAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSTVQSGSLALPGAPTNEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGMPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 459, "header": "tr|A0AAA9S8D4-1|A0AAA9T1Y3_BOVIN Computationally mapped isoform of Polypyrimidine tract-binding protein 3 OS=Bos taurus OX=9913 GN=PTBP3 PE=3 SV=1 CANONICAL=A0AAA9T1Y3-1" }, "locus": { "chromosome": "8", "start_pos": 101699927, "end_pos": 101635408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134583.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134583.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078414.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078414.1" } ] } }, { "isoform_ac": "A0AAA9T1Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#A0AAA9T1Y3-1", "sequence": { "sequence": "MAAAEDELLLPRLPELFETSKQLLDEVEIAAEPTSSQIIQDKVFKGLDLLKKAAEMLSQLDLFSQNEDLEEIASTDLKYLMVPAFQGAFTMKQVSPSKRLDHLQWAREHFLNFLTQCQYYHVAKFELPKTKTNLAGNNTANSSMAYPSIIAMASQRQAKKERYKQKKEVEHRLSALKSAVESGQADDEHVREYYLLHLRRWIGISLEEIESIDQEIKILREKDSTHEASTSQSSHQDRPPMKPFVLTQNMAQAKVFGAGYPSLASMTVNDWYEQHRKFGALPDQGIATTMSEFKRAAQQQEDQEHEEEEDDEQAVCRAREWDDWKDTHPRGYGNRQNMANGNDNKKFKGDRPLCSPSRVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSTVQSGSLALPGAPTNEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGMPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 853, "header": "tr|A0AAA9T1Y3-1|A0AAA9T1Y3_BOVIN Isoform 1 of Polypyrimidine tract-binding protein 3 OS=Bos taurus OX=9913 GN=PTBP3 PE=3 SV=1 CANONICAL=A0AAA9T1Y3-1" }, "locus": { "chromosome": "8", "start_pos": 101689455, "end_pos": 101635408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099147.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099147.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090584.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090584.1" } ] } }, { "isoform_ac": "F1MPG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3/entry#F1MPG6-1", "sequence": { "sequence": "MNNSTPAGVYANGNDNKKFKGDRPLCSPSRVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSTVQSGSLALPGAPTNEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGMPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 499, "header": "tr|F1MPG6-1|A0AAA9T1Y3_BOVIN Computationally mapped isoform of Polypyrimidine tract-binding protein 3 OS=Bos taurus OX=9913 GN=PTBP3 PE=3 SV=4 CANONICAL=A0AAA9T1Y3-1" }, "locus": { "chromosome": "8", "start_pos": 101699955, "end_pos": 101635408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022272.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022272.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022272.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022272.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104968451", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968451", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XPG4-1", "protein_name": "Polypyrimidine tract binding protein 3", "gene_name": "PTBP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQEEMTSEDETKQTTEEGEEDLVTDVSDDGFKMCLSIYVVLGRVLGQNIAVCLFSSDSLSQHGPDNLLSSSVSGKPLTVSNSTPAKGGGNDNKKLKGGRLPCLPSRVLHLRQIPDNATEADVISLGLPFGKVTNVLILRGKSQAFLEMASEENAVSMVNYCSTAIPHIHNQPVYVQYSNHRELKTDSLPSQASAQAALQVVNTVQCGNVGVTSTFAAESGLPPGHSSVLRIIIENLFYPVSLEVLYQIFSKFGFVLKIVTFTRNNQFQALIQYAEPVNAYYAKMALNGRNIYNACCTLHIDFSKLTSLKVKYNNEKSRDFTRFDLPAADGQLPLDPAIIAAFGSQGIIFQPYVGTGGIGPVTYFPQGAVTTSVASVRMSNPGVPGNSVLLVSNLNPEAITPHGLFILFGAYGDVLRVKIMFKNKENALVQMADATQAQIAISNLNGQKLYGKFIRATLSKHQNIQLPREGEEDNGLTKDYSNSPLHRFKNPGSKNFQNIFPPSATLHLSNIPPSVSFDDLKSLFARTGSTVKAFRFFQRDCKMALIQLGSVEEAVHALIELHNYDLGENHHLRVSFSKSTI", "length": 581 }, "evidence": [ { "id": "A0AAA9T1Y3", "url": "https://omabrowser.org/oma/group/A0AAA9T1Y3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FB37-1", "protein_name": "Polypyrimidine tract-binding protein 1", "gene_name": "ptbp3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSSTPSTTANGTDSKQYKGDRSPCAPSRVLHVRKVPIEVSEAEVVSLGVPFGKVTNLLMLKGKNQAFIEMASEEAAMTMVNYYTTATPHVRNQPVYIQYSNHRELKTDNLPNQGRAQAALQAVNAVHTGNMSLSGTATASDGGMMPGQSPVLRIIVENLYYPVSLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPMNAHHAKVALDGQNIYNGCCTLRVEFSKLTSLNVKYNNDKSRDFTRLDLPSGDGQPTLDPTMQTAFGAPGIISSPYPGAAGFAPAIGFPQAGLSMQAMPGALGPLTIPSSAMTGRMAIHGMTPTAIHSVLLVSNLNPDSISPHELFILFGVYGDVHRVKILFNKKENALIQMADATQAQLAMSHLNGQRLYGKVIRVTISKHQTVQLPREGQEDQGLTKDFSGSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSTTDDFLKDLFASSGYTVKAFKFFQKDRKMALIQLGSVEEAIQALIHLHNHDLGENHHLRVSFSKSTI", "length": 522 }, "evidence": [ { "id": "A0AAA9T1Y3", "url": "https://omabrowser.org/oma/group/A0AAA9T1Y3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O95758-3", "protein_name": "Polypyrimidine tract-binding protein 3", "gene_name": "PTBP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 552 }, "evidence": [ { "id": "A0AAA9T1Y3", "url": "https://omabrowser.org/oma/group/A0AAA9T1Y3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BHD7-1", "protein_name": "Polypyrimidine tract-binding protein 3", "gene_name": "Ptbp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAIAFPQAAGLSVPAVPGALGPLTLTSSAVSGRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 523 }, "evidence": [ { "id": "A0AAA9T1Y3", "url": "https://omabrowser.org/oma/group/A0AAA9T1Y3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Z118-1", "protein_name": "Polypyrimidine tract-binding protein 3", "gene_name": "Ptbp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATSNEGTLLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAIAFPQAAGLSVSAVPGALGPLTLTSSAVSGRMAIPGASGIPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI", "length": 523 }, "evidence": [ { "id": "A0AAA9T1Y3", "url": "https://omabrowser.org/oma/group/A0AAA9T1Y3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "erythrocyte maturation", "id": "GO:0043249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "regulation of cell differentiation", "id": "GO:0045595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045595", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1Y3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Y3" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 358, "end_pos": 442, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 141, "end_pos": 143 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T218-1", "uniprot_ac": "A0AAA9T218", "uniprot_id": "A0AAA9T218_BOVIN", "mass": { "chemical_mass": 52525.0, "monoisotopic_mass": 52525.0 }, "refseq": {}, "gene_names": [ { "name": "LIPI", "type": "recommended", "evidence": [ { "id": "A0AAA9T218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ] } ], "protein_names": [ { "name": "Lipase I", "type": "synonym", "evidence": [ { "id": "A0AAA9T218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218#function" }, { "database": "UniProtKB", "id": "ARBA00049600", "url": "https://www.uniprot.org/uniprotkb/ARBA00049600#function" }, { "database": "UniProtKB", "id": "A0AAA9SZE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE1#function" }, { "database": "UniProtKB", "id": "F6R8Y6", "url": "https://www.uniprot.org/uniprotkb/F6R8Y6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LIPI", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218", "locus": { "chromosome": "1", "start_pos": 23047283, "end_pos": 22966713, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038512", "url": "https://www.ensembl.org/id/ENSBTAG00000038512" } ] } } ], "crossref": [ { "id": "A0AAA9T218", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T218", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048954", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048954", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00707", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00707", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033906", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033906", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11610", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11610", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11610:SF103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11610:SF103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00151", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00151", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "40943", "url": "https://www.rhea-db.org/rhea/40943", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LME3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LME3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LME3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2G6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T218-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8Y6", "url": "https://www.uniprot.org/uniprotkb/F6R8Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8Y6-1", "url": "https://www.uniprot.org/uniprotkb/F6R8Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVYIFLCLMCWARSENKAPCLEFSHLSLKDSFRDLFNPQMEISLMLYTRKNPTCAESLFEKNDSLNINFNTSKKAVWLIHGYRPLGSTPSWLQNFVRILLNQDDMNIIVVDWNRGATTFLYVRAVKNTRKVAVSLSRYIQNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGRVGRITGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLGIKQPLGHIDFYPNGGKKQPGCPKSIFSGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCTYYFVLSIIVLDKNMKDGYVTFKLLNQLGIVEEPRLYERHKIFYKLQEFKILGQFLNDVANISSIGLAYFQSSNQQCSMCKYTIQLLKLKSLTYPERPPLCIYNFVLKESKELFLTPSTCKPREI", "length": 460, "header": "tr|A0AAA9T218-1|A0AAA9T218_BOVIN Isoform 1 of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=1 CANONICAL=A0AAA9T218-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LME3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#A0A3Q1LME3-1", "sequence": { "sequence": "MRVYIFLCLMCWARSGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLGIKQPLGHIDFYPNGGKKQPGCPKSIFSGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCTYYFVLSIIVLDKNMKDGYVTFKLLNQLGIVEEPRLYERHKIFYKLQEFKILGQFLNDVANISSIGLAYFQSSNQQCSMCKYTIQLLKLKSLTYPERPPLCIYNFVLKESKELFLTPSTCKPREI", "length": 295, "header": "tr|A0A3Q1LME3-1|A0AAA9T218_BOVIN Computationally mapped isoform of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=2 CANONICAL=A0AAA9T218-1" }, "locus": { "chromosome": "1", "start_pos": 23047064, "end_pos": 22975444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075560.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075560.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057833.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057833.2" } ] } }, { "isoform_ac": "A0AAA9S2G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#A0AAA9S2G6-1", "sequence": { "sequence": "MRVYIFLCLMCWARSENKAPCLEFSHLSLKDSFRDLFNPQMEISLMLYTRKNPTCAESLFEKNDSLNINFNTSKKAVWLIHGYRPLGSTPSWLQNFVRILLNQDDMNIIVVDWNRGATTFLYVRAVKNTRKVAVSLSRYIQNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGRVGRITGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCTYYFVLSIIVLDKNMKDGYVTFKLLNQLGIVEEPRLYERHKIFYKLQEFKILGQFLNDVANISSIGLAYFQSSNQQCSMCKYTIQLLKLKSLTYPERPPLCIYNFVLKESKELFLTPSTCKPREI", "length": 430, "header": "tr|A0AAA9S2G6-1|A0AAA9T218_BOVIN Computationally mapped isoform of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=1 CANONICAL=A0AAA9T218-1" }, "locus": { "chromosome": "1", "start_pos": 23047064, "end_pos": 22975444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122873.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122873.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077498.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077498.1" } ] } }, { "isoform_ac": "A0AAA9SZE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#A0AAA9SZE1-1", "sequence": { "sequence": "MRVYIFLCLMCWARSENKAPCLEFSHLSLKDSFRDLFNPQMEISLMLYTRKNPTCAESLFEKNDSLNINFNTSKKAVWLIHGYRPLGSTPSWLQNFVRILLNQDDMNIIVVDWNRGATTFLYVRAVKNTRKVAVSLSRYIQNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGRVGRITGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLGIKQPLGHIDFYPNGGKKQPGCPKSIFSGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCNHHYASIILYLKKARNYFSLQAHANHVKYKMPSSIKCNSLL", "length": 376, "header": "tr|A0AAA9SZE1-1|A0AAA9T218_BOVIN Computationally mapped isoform of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=1 CANONICAL=A0AAA9T218-1" }, "locus": { "chromosome": "1", "start_pos": 23047101, "end_pos": 22975444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094883.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094883.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089666.1" } ] } }, { "isoform_ac": "A0AAA9T218-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#A0AAA9T218-1", "sequence": { "sequence": "MRVYIFLCLMCWARSENKAPCLEFSHLSLKDSFRDLFNPQMEISLMLYTRKNPTCAESLFEKNDSLNINFNTSKKAVWLIHGYRPLGSTPSWLQNFVRILLNQDDMNIIVVDWNRGATTFLYVRAVKNTRKVAVSLSRYIQNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGRVGRITGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLGIKQPLGHIDFYPNGGKKQPGCPKSIFSGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCTYYFVLSIIVLDKNMKDGYVTFKLLNQLGIVEEPRLYERHKIFYKLQEFKILGQFLNDVANISSIGLAYFQSSNQQCSMCKYTIQLLKLKSLTYPERPPLCIYNFVLKESKELFLTPSTCKPREI", "length": 460, "header": "tr|A0AAA9T218-1|A0AAA9T218_BOVIN Isoform 1 of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=1 CANONICAL=A0AAA9T218-1" }, "locus": { "chromosome": "1", "start_pos": 23047064, "end_pos": 22975444, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102214.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102214.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091772.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091772.1" } ] } }, { "isoform_ac": "F6R8Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218/entry#F6R8Y6-1", "sequence": { "sequence": "MSRIRPGPWEKNKAPCLEFSHLSLKDSFRDLFNPQMEISLMLYTRKNPTCAESLFEKNDSLNINFNTSKKAVWLIHGYRPLGSTPSWLQNFVRILLNQDDMNIIVVDWNRGATTFLYVRAVKNTRKVAVSLSRYIQNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGRVGRITGLDPAGPQFSGKPSTGRLDYTDADFVDVIHTDTNGLGIKQPLGHIDFYPNGGKKQPGCPKSIFSGLEFIKCDHQRAVYLFMAALETSCNFISFSCRSYKDYKTGLCADCADFKGKSCPKLGYQTELWKDILKERIENTTLRTTVFLDTVGTNPFCTYYFVLSIIVLDKNMKDGYVTFKLLNQLGIVEEPRLYERHKIFYKLQEFKILGQFLNDVANISSIGLAYFQSSNQQCSMCKYTIQLLKLKSLTYPERPPLCIYNFVLKESKELFLTPSTCKPREI", "length": 455, "header": "tr|F6R8Y6-1|F6R8Y6_BOVIN Computationally mapped isoform of Lipase I OS=Bos taurus OX=9913 GN=LIPI PE=3 SV=1 CANONICAL=A0AAA9T218-1" }, "locus": { "chromosome": "1", "start_pos": 23047064, "end_pos": 22966961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053236.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053236.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051892.2", "url": "https://www.ensembl.org/id/ENSBTAP00000051892.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 89, "start_aa": "Thr", "end_pos": 89, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr89", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "lipase activity", "id": "GO:0016298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016298", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "carboxylic ester hydrolase activity", "id": "GO:0052689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "phospholipase activity", "id": "GO:0004620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004620", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" }, { "name": "phosphatidic acid biosynthetic process", "id": "GO:0006654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T218", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T218" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "40943", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O46606-1" ], "evidence": [ { "id": "40943", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40943" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O46606", "gene_name": "DDHD1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O46606", "database": "UniProtKB", "url": 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"Zinc finger protein 287", "type": "recommended", "evidence": [ { "id": "A0AAA9T3L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LNF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNF1#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF287", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1", "locus": { "chromosome": "19", "start_pos": 33143488, "end_pos": 33124716, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049358", "url": "https://www.ensembl.org/id/ENSBTAG00000049358" } ] } } ], "crossref": [ { "id": "A0AAA9T3L1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3L1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049358", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049358", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M274", "url": "https://www.orthodb.org/?gene=A0A3Q1M274", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23234:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23234:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LNF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M274", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M274", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M274-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M274-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSPSRRTTSSSRAQVLLTWKTDKAQSGPRNAEKEILALRLLRDTETCRQNFRNFPYPDLAGPRKALNQLRELCLKWLRPEIHSKEQILELLVLEQFLSILPGEVRTWVKSQYPRNSEEVVTLVEDLTQILKEEAAPQNFTLSQETPEDDPKGRQAFQAGWFNDLVTKESVTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGERLSVPPNHTHARVCLSSALKSGLGLEVNMLICSGTETANFCSLFPDERFQSERSSGTTMHGPPRPPPHALPSACLPHSLCTRILQGGGRFLSLLQKGSDLIHEIVSESFFSCKRSVLMGLTVYRPTVIPMLEEPWMVLKEILEGPSPEWETKAQECTLVENVSKLKKDGIKLIKLEEPSDYDDRMEGQVAETFRRIPTKRRHFGVKKSVLSQEDGPVEDYKYDIYRSDFEKHSNLIMQFGTQSDNKTFMYDEDKTFIPGVVHRKIYPGEKPYKCKVCGKKFRKYPSLIAHQNSHAKEKSYECEECGKEFRHVSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICSICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNACNKDFSQRTCLIQHQRIHTGEKPYACRICGKSFTQSTNLIQHQRVHTGAKNRN", "length": 877, "header": "tr|A0AAA9T3L1-1|A0AAA9T3L1_BOVIN Isoform 1 of Zinc finger protein 287 OS=Bos taurus OX=9913 GN=ZNF287 PE=3 SV=1 CANONICAL=A0AAA9T3L1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1/entry#A0A3Q1LNF1-1", "sequence": { "sequence": "MFSPSRRTTSSSRAQVLLTWKTDKAQSGPRNAEKEILALRLLRDTETCRQNFRNFPYPDLAGPRKALNQLRELCLKWLRPEIHSKEQILELLVLEQFLSILPGEVRTWVKSQYPRNSEEVVTLVEDLTQILKEEAAPQNFTLSQETPEDDPKGRQAFQAGWFNDLVTKESVTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPMLEEPWMVLKEILEGPSPEWETKAQECTLVENVSKLKKDGIKLIKLEEPSDYDDRMEGQVAETFRRIPTKRRHFGVKKSVLSQEDGPVEDYKYDIYRSDFEKHSNLIMQFGTQSDNKTFMYDEDKTFIPGVVHRKIYPGEKPYKCKVCGKKFRKYPSLIAHQNSHAKEKSYECEECGKEFRHVSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICSICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNACNKDFSQRTCLIQHQRIHTGEKPYACRICGKSFTQSTNLIQHQRVHTGHREVVPRHRVLPSRSENAK", "length": 771, "header": "tr|A0A3Q1LNF1-1|A0AAA9T3L1_BOVIN Computationally mapped isoform of Zinc finger protein 287 OS=Bos taurus OX=9913 GN=ZNF287 PE=3 SV=1 CANONICAL=A0AAA9T3L1-1" }, "locus": { "chromosome": "19", "start_pos": 33142634, "end_pos": 33126011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084056.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084056.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058498.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058498.2" } ] } }, { "isoform_ac": "A0A3Q1M274-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1/entry#A0A3Q1M274-1", "sequence": { "sequence": "MFSPSRRTTSSSRAQVLLTWKTDKAQSGPRNAEKEILALRLLRDTETCRQNFRNFPYPDLAGPRKALNQLRELCLKWLRPEIHSKEQILELLVLEQFLSILPGEVRTWVKSQYPRNSEEVVTLVEDLTQILKEEAAPQNFTLSQETPEDDPKGRQAFQAGWFNDLVTKESVTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLDERFQSERSSGTTMHGPPRPPPHALPSACLPHSLCTRILQGGGRFLSLLQKGSDLIHEIVSESFFSCKRSVLMGLTVYRPTVIPMLEEPWMVLKEILEGPSPEWETKAQECTLVENVSKLKKDGIKLIKLEEPSDYDDRMEGQVAETFRRIPTKRRHFGVKKSVLSQEDGPVEDYKYDIYRSDFEKHSNLIMQFGTQSDNKTFMYDEDKTFIPGVVHRKIYPGEKPYKCKVCGKKFRKYPSLIAHQNSHAKEKSYECEECGKEFRHVSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICSICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNACNKDFSQRTCLIQHQRIHTGEKPYACRICGKSFTQSTNLIQHQRVHTGAKNRN", "length": 830, "header": "tr|A0A3Q1M274-1|A0AAA9T3L1_BOVIN Computationally mapped isoform of Zinc finger protein 287 OS=Bos taurus OX=9913 GN=ZNF287 PE=3 SV=2 CANONICAL=A0AAA9T3L1-1" }, "locus": { "chromosome": "19", "start_pos": 33136710, "end_pos": 33126011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079222.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079222.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064104.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064104.2" } ] } }, { "isoform_ac": "A0AAA9T3L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1/entry#A0AAA9T3L1-1", "sequence": { "sequence": "MFSPSRRTTSSSRAQVLLTWKTDKAQSGPRNAEKEILALRLLRDTETCRQNFRNFPYPDLAGPRKALNQLRELCLKWLRPEIHSKEQILELLVLEQFLSILPGEVRTWVKSQYPRNSEEVVTLVEDLTQILKEEAAPQNFTLSQETPEDDPKGRQAFQAGWFNDLVTKESVTFKDVAVDITQEDWELMRPVQKELYKTVTLQNYWNMVSLGERLSVPPNHTHARVCLSSALKSGLGLEVNMLICSGTETANFCSLFPDERFQSERSSGTTMHGPPRPPPHALPSACLPHSLCTRILQGGGRFLSLLQKGSDLIHEIVSESFFSCKRSVLMGLTVYRPTVIPMLEEPWMVLKEILEGPSPEWETKAQECTLVENVSKLKKDGIKLIKLEEPSDYDDRMEGQVAETFRRIPTKRRHFGVKKSVLSQEDGPVEDYKYDIYRSDFEKHSNLIMQFGTQSDNKTFMYDEDKTFIPGVVHRKIYPGEKPYKCKVCGKKFRKYPSLIAHQNSHAKEKSYECEECGKEFRHVSSLIAHQRMHTGEKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPYKCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNECWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICSICGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQGANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNACNKDFSQRTCLIQHQRIHTGEKPYACRICGKSFTQSTNLIQHQRVHTGAKNRN", "length": 877, "header": "tr|A0AAA9T3L1-1|A0AAA9T3L1_BOVIN Isoform 1 of Zinc finger protein 287 OS=Bos taurus OX=9913 GN=ZNF287 PE=3 SV=1 CANONICAL=A0AAA9T3L1-1" }, "locus": { "chromosome": "19", "start_pos": 33136710, "end_pos": 33126011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112837.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112837.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092359.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092359.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 778, "end_pos": 780, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3L1" }, { "id": "PS50157", "database": "PROSITE", "url": 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"start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 139, "end_pos": 141 }, { "start_pos": 219, "end_pos": 221 }, { "start_pos": 373, "end_pos": 375 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 722, "end_pos": 724 }, { "start_pos": 778, "end_pos": 780 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3P5-1", "uniprot_ac": "A0AAA9T3P5", "uniprot_id": "A0AAA9T3P5_BOVIN", "mass": { "chemical_mass": 167104.0, "monoisotopic_mass": 167104.0 }, "refseq": { "ac": "XP_010819158", "name": "remodeling and spacing factor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819158" }, "gene_names": [ { "name": "RSF1", "type": "recommended", "evidence": [ { "id": "A0AAA9T3P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ] }, { "name": "RSF1", "type": "synonym", "evidence": [ { "id": "XP_010819158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819158" } ] } ], "protein_names": [ { "name": "Remodeling and spacing factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T3P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5/entry#names_and_taxonomy" } ] }, { "name": "remodeling and spacing factor 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010819158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819158" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RSF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5", "locus": { "chromosome": "29", "start_pos": 18331621, "end_pos": 18188732, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020268", "url": "https://www.ensembl.org/id/ENSBTAG00000020268" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020268", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15543", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15543", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541248", "url": "https://www.ncbi.nlm.nih.gov/gene/541248", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541248", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541248", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCDNTHG", "url": "https://omabrowser.org/oma/group/SCDNTHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LP30", "url": "https://www.orthodb.org/?gene=A0A3Q1LP30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MLK1", "url": "https://www.orthodb.org/?gene=F1MLK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14296", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14296", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14296:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14296:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010819158", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010819158", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP30", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3P5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLK1", "url": "https://www.uniprot.org/uniprotkb/F1MLK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLK1-1", "url": "https://www.uniprot.org/uniprotkb/F1MLK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDSSSRESPSLEEEETKKEEETTKQGIVCRLWTERRGKGRRHRSTEPCNSCLESLQVCQGTLLLHCDFEEEQKGSAKMKSEERPIDSEKCSTPSALEETTVKIEKEDEKELVKLPVIVKLEKPFPESEEKKIIKEESDSFKENVKPVKVEMKECKADPRDIKGSMEKLEPERLEFVGNVKSSQEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPIKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDEKVTPHFKTEQMETKFYDSKEDSCSPSKDRSVIMEGNGAESVNSVIPSVKIGDLEKEVVPLGKDTDNSISVLETPSQKEYIDETGPSEMETSLETAEVAKDLCLKTALSATESYSMRVEEKSPKSKKDKRPPVLECLEKSKKTFLDKDIQRLSPIPEEVPKTTVESEKAGSPEAAETYPSSNVTVHCEKLASEVECQNTSSLEGHSLEKVDPEILKVDSESTKVEVDNLDNAQTSGTGDPSETKGSMQKSKLKYKLIPEEENTASENTEITSERQKEGIKLTIRISSRKKKSDSPPKILEPETKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEEDEVEEESAALQKTDKKENLKKAEKDTNSKVAKVKPKGKVRWTGSRTRGRWKYSSNDESEGSDSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDHEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKRKCSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSDSEESYMSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEGKPSRKRLHRIETDEEESCDNAHGDADQPAHDRQPRVLPSEQDSTKKPYRIDSDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPAEKPQTPKDSSTASASLAPNGTSGGQEAGAPEEDEDELLRVTDLVDYVCNSEQL", "length": 1473, "header": "tr|A0AAA9T3P5-1|A0AAA9T3P5_BOVIN Isoform 1 of Remodeling and spacing factor 1 OS=Bos taurus OX=9913 GN=RSF1 PE=4 SV=1 CANONICAL=A0AAA9T3P5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5/entry#A0A3Q1LP30-1", "sequence": { "sequence": 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"length": 1411, "header": "tr|A0A3Q1LP30-1|A0AAA9T3P5_BOVIN Computationally mapped isoform of Remodeling and spacing factor 1 OS=Bos taurus OX=9913 GN=RSF1 PE=4 SV=2 CANONICAL=A0AAA9T3P5-1" }, "locus": { "chromosome": "29", "start_pos": 18330617, "end_pos": 18188931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083436.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083436.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058640.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058640.2" } ] } }, { "isoform_ac": "A0AAA9T3P5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5/entry#A0AAA9T3P5-1", "sequence": { "sequence": "MAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDSSSRESPSLEEEETKKEEETTKQGIVCRLWTERRGKGRRHRSTEPCNSCLESLQVCQGTLLLHCDFEEEQKGSAKMKSEERPIDSEKCSTPSALEETTVKIEKEDEKELVKLPVIVKLEKPFPESEEKKIIKEESDSFKENVKPVKVEMKECKADPRDIKGSMEKLEPERLEFVGNVKSSQEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPIKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDEKVTPHFKTEQMETKFYDSKEDSCSPSKDRSVIMEGNGAESVNSVIPSVKIGDLEKEVVPLGKDTDNSISVLETPSQKEYIDETGPSEMETSLETAEVAKDLCLKTALSATESYSMRVEEKSPKSKKDKRPPVLECLEKSKKTFLDKDIQRLSPIPEEVPKTTVESEKAGSPEAAETYPSSNVTVHCEKLASEVECQNTSSLEGHSLEKVDPEILKVDSESTKVEVDNLDNAQTSGTGDPSETKGSMQKSKLKYKLIPEEENTASENTEITSERQKEGIKLTIRISSRKKKSDSPPKILEPETKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEEDEVEEESAALQKTDKKENLKKAEKDTNSKVAKVKPKGKVRWTGSRTRGRWKYSSNDESEGSDSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDHEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKRKCSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSDSEESYMSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEGKPSRKRLHRIETDEEESCDNAHGDADQPAHDRQPRVLPSEQDSTKKPYRIDSDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPAEKPQTPKDSSTASASLAPNGTSGGQEAGAPEEDEDELLRVTDLVDYVCNSEQL", "length": 1473, "header": "tr|A0AAA9T3P5-1|A0AAA9T3P5_BOVIN Isoform 1 of Remodeling and spacing factor 1 OS=Bos taurus OX=9913 GN=RSF1 PE=4 SV=1 CANONICAL=A0AAA9T3P5-1" }, "locus": { "chromosome": "29", "start_pos": 18330617, "end_pos": 18188931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111229.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111229.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092396.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092396.1" } ] } }, { "isoform_ac": "F1MLK1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5/entry#F1MLK1-1", "sequence": { "sequence": "MAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDSSSRESPSLEEEETKKEEETTKQGNSCLESLQVCQGTLLLHCDFEEEQKGSAKMKSEERPIDSEKCSTPSALEETTVKIEKEDEKELVKLPVIVKLEKPFPESEEKKIIKEESDSFKENVKPVKVEMKECKADPRDIKGSMEKLEPERLEFVGNVKSSQEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPIKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDEKVTPHFKTEQMETKFYDSKEDSCSPSKDRSVIMEGNGAESVNSVIPSVKIGDLEKEVVPLGKDTDNSISVLETPSQKEYIDETGPSEMETSLETAEVAKDLCLKTALSATESYSMRVEEKSPKSKKDKRPPVLECLEKSKKTFLDKDIQRLSPIPEEVPKTTVESEKAGSPEAAETYPSSNVTVHCEKLASEVECQNTSSLEGHSLEKVDPEILKVDSESTKVEVDNLDNAQTSGTGDPSETKGSMQKSKLKYKLIPEEENTASENTEITSERQKEGIKLTIRISSRKKKSDSPPKILEPETKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEEDEVEEESAALQKTDKKENLKKAEKDTNSKVAKVKPKGKVRWTGSRTRGRWKYSSNDESEGSDSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDHEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKRKCSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSDSEESYMSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEGKPSRKRLHRIETDEEESCDNAHGDADQPAHDRQPRVLPSEQDSTKKPYRIDSDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPAEKPQTPKDSSTASASLAPNGTSGGQEAGAPEEDEDELLRVTDLVDYVCNSEQL", "length": 1451, "header": "tr|F1MLK1-1|A0AAA9T3P5_BOVIN Computationally mapped isoform of Remodeling and spacing factor 1 OS=Bos taurus OX=9913 GN=RSF1 PE=4 SV=4 CANONICAL=A0AAA9T3P5-1" }, "locus": { "chromosome": "29", "start_pos": 18330617, "end_pos": 18188931, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061202.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061202.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053604.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053604.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541248", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541248", "resource": "KEGG Pathway" }, { "id": "R-BTA-606279", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "resource": "Reactome", "description": "Deposition of new CENPA-containing nucleosomes at the centromere" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XDX9-1", "protein_name": "Remodeling and spacing factor 1", "gene_name": "RSF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"length": 1424 }, "evidence": [ { "id": "A0AAA9T3P5", "url": "https://omabrowser.org/oma/group/A0AAA9T3P5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZGQ8-1", "protein_name": "Remodeling and spacing factor 1", "gene_name": "Rsf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1448 }, "evidence": [ { "id": "A0AAA9T3P5", "url": "https://omabrowser.org/oma/group/A0AAA9T3P5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9PWW9-1", "protein_name": "Remodeling and spacing factor 1", "gene_name": "Rsf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAAAAAAAAAAAMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDIGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQEDSSRESPTLEDEETKKDEETPKQEASKENEKTGADERSVDSGKCSAASALEEPAVKTEKADEKELAKLPVIVKLEKPLPETEEKKIIREESDSFKENVKPIKVEAKECRADPKDLKGSLERLGSQEPERADFGSNIKSQDIIEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSATPTKEVLKDDIKQEEETCKRVSTISALSHEGKQLVNGEINDDKVIPNFKTEQMEIQLCDTKEDSASIPAKDGNACMEGNGTECLNSVITSTKTSELEKEAPLGKGIDSSVPDIESLSQKARLEEPGLLNMDMPLEPSEKATDLSLKPTLSATEPCSTKVEEKAPRSKSENHTPGIECLERVEKAKKTSIDKDIQKLSPIPEEVVRGALESEKSGPCEVAETPLPLSMAGAKEKQTSEKKDVDCSRGSSESQSLENASPEILKEDSESSREEVAKLDNAQTSGMEDTSETKGSVQKNKFKYKLVSERNSTASENTEITSERKKEGIKLTIRISSRKKKPDCPPQTVDSESKEEKAGKEEEKASVGRTLRRSPRISRPTAKVAEIRVQKADKRRADGEDGVEGEPASLQTADKKDHLKKAEKDTNSKASKVKPKGKVRWTGSRTRGRWKYSSNDESEGSESDKSSAALEEEEGKEGEEAVLPDDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPEFSEEQEEKKKDAKKSKANALERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEEPPSNEDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESFMSKNSEDDELTKESKRSVRKRGRSTDDYSEADEDDEEEGKPSRKRLHRIETDEESCDNAHGDADQPARDSQPSALPSEQESSKKPYRIESDEEEDFENKVGSPLDYSLVDLPSTNGQSPGKAIENLMGKATEKSQTPKDNGTASASLAPNGTSGGQEVGAPEEDEDELLRVTDLVDYVCNSEQL", "length": 1441 }, "evidence": [ { "id": "A0AAA9T3P5", "url": "https://omabrowser.org/oma/group/A0AAA9T3P5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96T23-1", "protein_name": "Remodeling and spacing factor 1", "gene_name": "RSF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQL", "length": 1441 }, "evidence": [ { "id": "A0AAA9T3P5", "url": "https://omabrowser.org/oma/group/A0AAA9T3P5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "histone octamer slider activity", "id": "GO:0140751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140751", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" }, { "name": "positive regulation of viral transcription", "id": "GO:0050434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050434", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3P5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3P5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 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{ "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T157-1", "uniprot_ac": "A0AAA9T157", "uniprot_id": "A0AAA9T157_BOVIN", "mass": { "chemical_mass": 54078.0, "monoisotopic_mass": 54078.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC174", "type": "recommended", "evidence": [ { "id": "A0AAA9T157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 174", "type": "synonym", "evidence": [ { "id": "A0AAA9T157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T157", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC174", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157", "locus": { "chromosome": "22", "start_pos": 57604495, "end_pos": 57627476, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038298", "url": "https://www.ensembl.org/id/ENSBTAG00000038298" } ] } } ], "crossref": [ { "id": "A0AAA9T157", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T157", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR025066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15885", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15885", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15885:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15885:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25449", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25449", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LQR8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T157", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T157-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDAGVLGKPKPTNKKPSIWSKQNAGVSNRAEKDAEQKIEEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKMIDKQKEMEAIGASRGYRKTEERDDDEGALSEKDIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPDLLEMDKNLQGRLFVSPANEKTLLSEDMRKELQRQQWEEEEREALRRPMGPVHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRTKRENIKEKRKAILEARLAKLRQKKMKKSKEDGAEEENRDGDVIGPLPPEPEVTPAPRTAAQSSKVEVIVQERKDTRPGVPHVREWDRGKDFSFGYWSKRQSDLRAERDPEFAPPSYYFVDQKRTESLSSQAWSRPAPAQRDPGQHSDQSHDPCASQTSSAPAPSSPPQAPTVTFETLDDMISYYKQVG", "length": 467, "header": "tr|A0AAA9T157-1|A0AAA9T157_BOVIN Isoform 1 of Coiled-coil domain containing 174 OS=Bos taurus OX=9913 GN=CCDC174 PE=4 SV=1 CANONICAL=A0AAA9T157-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157/entry#A0A3Q1LQR8-1", "sequence": { "sequence": "MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDAGVLGKPKPTNKKPSIWSKQNAGVSNRAEKDAEQKIEEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKMIDKQKEMEAIGASRGYRKTEERDDDEGALSEKDIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPDLLEMDKNLQGRLFVSPANEKTLLSEDMRKELQRQQWEEEEREALRRPMGPVHYEDIRENDGDVIGPLPPEPEVTPAPRTAAQSSKVEVIVQERKDTRPGVPHVREWDRGKDFSFGYWSKRQSDLRAERDPEFAPPSYYFVDQKRTESLSSQAWSRPAPAQRDPGQHSDQSHDPCASQTSSAPAPSSPPQAPTVTFETLDDMISYYKQVT", "length": 391, "header": "tr|A0A3Q1LQR8-1|A0AAA9T157_BOVIN Computationally mapped isoform of Coiled-coil domain containing 174 OS=Bos taurus OX=9913 GN=CCDC174 PE=4 SV=1 CANONICAL=A0AAA9T157-1" }, "locus": { "chromosome": "22", "start_pos": 57627468, "end_pos": 57606366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085984.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085984.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057347.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057347.2" } ] } }, { "isoform_ac": "A0AAA9T157-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157/entry#A0AAA9T157-1", "sequence": { "sequence": "MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDAGVLGKPKPTNKKPSIWSKQNAGVSNRAEKDAEQKIEEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKMIDKQKEMEAIGASRGYRKTEERDDDEGALSEKDIPPPQDPSEEWVDYVDSLGRSRRCMRKDLPDLLEMDKNLQGRLFVSPANEKTLLSEDMRKELQRQQWEEEEREALRRPMGPVHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRTKRENIKEKRKAILEARLAKLRQKKMKKSKEDGAEEENRDGDVIGPLPPEPEVTPAPRTAAQSSKVEVIVQERKDTRPGVPHVREWDRGKDFSFGYWSKRQSDLRAERDPEFAPPSYYFVDQKRTESLSSQAWSRPAPAQRDPGQHSDQSHDPCASQTSSAPAPSSPPQAPTVTFETLDDMISYYKQVG", "length": 467, "header": "tr|A0AAA9T157-1|A0AAA9T157_BOVIN Isoform 1 of Coiled-coil domain containing 174 OS=Bos taurus OX=9913 GN=CCDC174 PE=4 SV=1 CANONICAL=A0AAA9T157-1" }, "locus": { "chromosome": "22", "start_pos": 57627468, "end_pos": 57605499, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089383.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T157", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T157" }, { "id": "PF25449", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25449" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCDC174 alpha/beta GRSR", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 191, "start_aa": "Trp", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2Q2-1", "uniprot_ac": "A0AAA9T2Q2", "uniprot_id": "A0AAA9T2Q2_BOVIN", "mass": { "chemical_mass": 92839.0, "monoisotopic_mass": 92839.0 }, "refseq": {}, "gene_names": [ { "name": "EFR3A", "type": "recommended", "evidence": [ { "id": "A0AAA9T2Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ] } ], "protein_names": [ { "name": "Protein EFR3 homolog A", "type": "recommended", "evidence": [ { "id": "A0AAA9T2Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2/entry#names_and_taxonomy" } ] }, { "name": "Protein EFR3-like", "type": "synonym", "evidence": [ { "id": "A0AAA9T2Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2#function" }, { "database": "UniProtKB", "id": "ARBA00057442", "url": "https://www.uniprot.org/uniprotkb/ARBA00057442#function" }, { "database": "UniProtKB", "id": "F1MLD7", "url": "https://www.uniprot.org/uniprotkb/F1MLD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFR3A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2", "locus": { "chromosome": "14", "start_pos": 9114601, "end_pos": 9201975, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047834", "url": "https://www.ensembl.org/id/ENSBTAG00000047834" } ] } } ], "crossref": [ { "id": "A0AAA9T2Q2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2Q2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047834", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047834", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QMCHANP", "url": "https://omabrowser.org/oma/group/QMCHANP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12444", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12444", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12444:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12444:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLD7", "url": "https://www.uniprot.org/uniprotkb/F1MLD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLD7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRTGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSYHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEADSRIGPPPSPSAADKEENPAVLAENCFRELLGRASFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDACKKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRFSVELEANDLQAGSTGNANVDTSSKDSDEKMVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVHKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILPNSIPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTITSGHAQYQSVPVYEMKFPDLCVY", "length": 821, "header": "tr|A0AAA9T2Q2-1|A0AAA9T2Q2_BOVIN Isoform 1 of Protein EFR3 homolog A OS=Bos taurus OX=9913 GN=EFR3A PE=3 SV=1 CANONICAL=A0AAA9T2Q2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2/entry#A0AAA9T2Q2-1", "sequence": { "sequence": "MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRTGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSYHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEADSRIGPPPSPSAADKEENPAVLAENCFRELLGRASFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDACKKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRFSVELEANDLQAGSTGNANVDTSSKDSDEKMVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVHKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILPNSIPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTITSGHAQYQSVPVYEMKFPDLCVY", "length": 821, "header": "tr|A0AAA9T2Q2-1|A0AAA9T2Q2_BOVIN Isoform 1 of Protein EFR3 homolog A OS=Bos taurus OX=9913 GN=EFR3A PE=3 SV=1 CANONICAL=A0AAA9T2Q2-1" }, "locus": { "chromosome": "14", "start_pos": 9201764, "end_pos": 9116430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102543.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102543.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089937.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089937.1" } ] } }, { "isoform_ac": "F1MLD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2/entry#F1MLD7-1", "sequence": { "sequence": "MKDYVQVPAAELEKPYELTSTGESPTLLCLRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRTGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSYHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEADSRIGPPPSPSAADKEENPAVLAENCFRELLGRASFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDACKKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRFSVELEANDLQAGSTGNANVDTSSKDSDEKMVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVHKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILPNSIPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTITSGHAQYQSVPVYEMKFPDLCVY", "length": 848, "header": "tr|F1MLD7-1|A0AAA9T2Q2_BOVIN Computationally mapped isoform of Protein EFR3 homolog A OS=Bos taurus OX=9913 GN=EFR3A PE=3 SV=4 CANONICAL=A0AAA9T2Q2-1" }, "locus": { "chromosome": "14", "start_pos": 9174530, "end_pos": 9116430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010169.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010169.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010169.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010169.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 333, "start_aa": "Thr", "end_pos": 333, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr333", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y447-1", "protein_name": "Protein EFR3 homolog A", "gene_name": "EFR3A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPARVCCCCAALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGAYLAERLSRDVVRHRYGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCDHDPETQTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEDVDSRTGPPSSPTGGEKEENPALLAENCFRELLGRATYGNMNNAVRPVFAHLDHHKLWDPNEFAVSCFKIIMYSIQAQYSHHVIQEILGHLDGCKKDPPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRISVDFELGDRRSSAGSATFSTSSKENDERIVQNAIIQTIGFFGSNLPDYQRSEIMMFIMGKVPVLGATSQSLDTSHLGDLGTRRIQIMLLRSLLMVTSGYKAMTITNALPAPFLDPLLSPSLMEDSELRQLVLEILHNLIDRHDNRAKLRGIRIIPDVSDLKIKRDKISRQDVSFMKKHGQQLYRHIYLGCKEEDNVQKNFELLYTSLALITIELANEEVVIDLIRLAIALQDVAIINEDNLPMFNRCGIMALVAAYLNFLSQMIAVPSFCQHVSKVIETRSLEASYFLPETIFKDKCNLPKSLEKHEKNLFFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILPGNNTEDKIDNTEEITFEALKKAIDNNGLEEQEKEKRRLVIEKFQKAPFEEIAAQCETKANLLHDRLAQILELTIRPPPSPSGTMTITAGHAHYQSVPVYEMKFPDLF", "length": 817 }, "evidence": [ { "id": "A0AAA9T2Q2", "url": "https://omabrowser.org/oma/group/A0AAA9T2Q2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4ADS9-1", "protein_name": "Protein EFR3 homolog A", "gene_name": "Efr3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGAYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRLGPPSSPSAADKEENPAVLAESCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARKKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRLSVELEASDSQKGSVGSVSLSSKDNDEKIVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIETRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILSNSVPSDDVVSNTEEITFEALKKAIDTNGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTVTSGHAQYQSVPVYEMKFPDLCVY", "length": 819 }, "evidence": [ { "id": "A0AAA9T2Q2", "url": "https://omabrowser.org/oma/group/A0AAA9T2Q2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14156-1", "protein_name": "Protein EFR3 homolog A", "gene_name": "EFR3A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKTDMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRIGPPSSPSATDKEENPAVLAENCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARKKDAPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRLSVEFEANDLQGGSVGSVNLNTSSKDNDEKIVQNAIIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHEKDLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILSNNVPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTITSGHAQYQSVPVYEMKFPDLCVY", "length": 821 }, "evidence": [ { "id": "A0AAA9T2Q2", "url": "https://omabrowser.org/oma/group/A0AAA9T2Q2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BG67-1", "protein_name": "Protein EFR3 homolog A", "gene_name": "Efr3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKADMEKLTFYAVSAPEKLDRIGAYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRLGPPSSPSAADKEENPAVLAESCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARRKDSPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRLSVELEANDSQKGSVGSVTVSSKDNDEKIVQNAVIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLSMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIETRTMEAPYFLPEHIFRDKCMLPKSLEKHDKNLYFLTNKIAESLGGSGYSVERLTVPYVPQVTDEDRLSRRKSIVDTVSIQVDILSNSVPSDDVVSNTEEITFEALKKAIDTNGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTVTSGHTQYQSVPVYEMKFPDLCVY", "length": 819 }, "evidence": [ { "id": "A0AAA9T2Q2", "url": "https://omabrowser.org/oma/group/A0AAA9T2Q2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" }, { "name": "synaptic vesicle priming", "id": "GO:0016082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 333 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T328-1", "uniprot_ac": "A0AAA9T328", "uniprot_id": "A0AAA9T328_BOVIN", "mass": { "chemical_mass": 33764.0, "monoisotopic_mass": 33764.0 }, "refseq": {}, "gene_names": [ { "name": "PHYHD1", "type": "recommended", "evidence": [ { "id": "A0AAA9T328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328" } ] } ], "protein_names": [ { "name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MFV0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFV0#function" }, { "database": "UniProtKB", "id": "ARBA00045487", "url": "https://www.uniprot.org/uniprotkb/ARBA00045487#function" }, { "database": "UniProtKB", "id": "A0AAA9T328", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328#function" }, { "database": "UniProtKB", "id": "F1MSW9", "url": "https://www.uniprot.org/uniprotkb/F1MSW9#function" }, { "database": "UniProtKB", "id": "A0ABI0P639", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P639#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T328", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHYHD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328", "locus": { "chromosome": "11", "start_pos": 99445102, "end_pos": 99423973, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038831", "url": "https://www.ensembl.org/id/ENSBTAG00000038831" } ] } } ], "crossref": [ { "id": "A0AAA9T328", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T328", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038831", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038831", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR008775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KYSEDNW", "url": "https://omabrowser.org/oma/group/KYSEDNW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFV0", "url": "https://www.orthodb.org/?gene=A0A3Q1MFV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSW9", "url": "https://www.orthodb.org/?gene=F1MSW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20883", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20883", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20883:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20883:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05721", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05721", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MFV0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T328", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T328-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P639", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P639", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P639-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P639-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSW9", "url": "https://www.uniprot.org/uniprotkb/F1MSW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSW9-1", "url": "https://www.uniprot.org/uniprotkb/F1MSW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACLIPSQLQKFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHSHKVQALARSLGLQMPVVVQSMYIFKQPHFGGEVAPHQDASFLYTEPLGRVLGLWIALEDAMLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWPANLPHGAAEYGGHSVTHTNGQDACIGH", "length": 305, "header": "tr|A0AAA9T328-1|A0AAA9T328_BOVIN Isoform 1 of Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=3 SV=1 CANONICAL=A0AAA9T328-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328/entry#A0A3Q1MFV0-1", "sequence": { "sequence": "MACLIPSQLQKFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHSHKVQQPHFGGEVAPHQDASFLYTEPLGRVLGLWIALEDAMLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWLQPTPELPFPPLYT", "length": 270, "header": "tr|A0A3Q1MFV0-1|A0AAA9T328_BOVIN Computationally mapped isoform of Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=3 SV=2 CANONICAL=A0AAA9T328-1" }, "locus": { "chromosome": "11", "start_pos": 99440984, "end_pos": 99424478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077279.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077279.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073098.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073098.2" } ] } }, { "isoform_ac": "A0AAA9T328-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328/entry#A0AAA9T328-1", "sequence": { "sequence": "MACLIPSQLQKFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHSHKVQALARSLGLQMPVVVQSMYIFKQPHFGGEVAPHQDASFLYTEPLGRVLGLWIALEDAMLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWPANLPHGAAEYGGHSVTHTNGQDACIGH", "length": 305, "header": "tr|A0AAA9T328-1|A0AAA9T328_BOVIN Isoform 1 of Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=3 SV=1 CANONICAL=A0AAA9T328-1" }, "locus": { "chromosome": "11", "start_pos": 99444098, "end_pos": 99424478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131265.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131265.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091023.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091023.1" } ] } }, { "isoform_ac": "A0ABI0P639-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328/entry#A0ABI0P639-1", "sequence": { "sequence": "VGCLSPFLDQFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHSHKVQALARSLGLQMPVVVQSMYIFKVSGPAAVAPHQDASFLYTEPLGRVLGLWIALEDAMLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWLQPTPELPFPPLYT", "length": 289, "header": "tr|A0ABI0P639-1|A0ABI0P639_BOVIN Computationally mapped isoform of Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=3 SV=1 CANONICAL=A0AAA9T328-1" }, "locus": { "chromosome": "11", "start_pos": 99440984, "end_pos": 99431387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138506.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138506.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106874.1" } ] } }, { "isoform_ac": "F1MSW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328/entry#F1MSW9-1", "sequence": { "sequence": "MACLIPSQLQKFQEDGFLVLEGFLSADECEAMQRRIDEIVAKMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDKQGNFLVPPEKSINKIGHALHALDPIFRCVTHSHKVQALARSLGLQMPVVVQSMYIFKQPHFGGEVAPHQDASFLYTEPLGRVLGLWIALEDAMLENGCLWFIPGSHTGGVSRRMVRTPAGSVPGTSFLGSEPIRDNSLFVPTPVLRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMEAAGTIWSPDNWLQPTPELPFPPLYT", "length": 291, "header": "tr|F1MSW9-1|A0AAA9T328_BOVIN Computationally mapped isoform of Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PHYHD1 PE=3 SV=1 CANONICAL=A0AAA9T328-1" }, "locus": { "chromosome": "11", "start_pos": 99440984, "end_pos": 99424478, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055396.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055396.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000048693.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1RR60-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "PHYHD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANLSPSQLQKFQEDGFLVLEGFLSAAECVAMQQRIGELVAEMDVPRHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKAINKIGHALHAHDPVFRCITHSPKVQALARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGMWMALEDATLENGCLWFIPGSHTGGVSRRMVRAPAGSAPGTSFLGSEPARDNNLFVPTPVRRGALVLIHGEVVHKSEQNLSDRSRQAYTFHLMDAADTVWSPENWLQPTAELPFPPLYT", "length": 291 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54XH6-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog", "gene_name": "phyhd1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLTEEQVAQYKKDGFLIIRNFNTTEEIDIVRGEMKKLIDELDTPSTISIFTTSEQERKVDDYFLGSGDKIRYFFEKGSIEDGKLIVPKDMAFNKVGHALHDLNPKFEEFSYSQKIHDLIYSLGIYNKALSGIMYIFKNQKIGGEVDIHQDSTFLHTTPLTTHAIWFAFEDSTIENGCLRGLPGSHTEGITRRFITDPNSESGCSFIKLAEDKQYNKSDFVALECKKGDIILLDGSVVHYSEPNTSPNSRHAYTLHFIEGDNGVIYENDNWLQSAKPFRVL", "length": 281 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5BJP9-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "Phyhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACLSPSQLKKFQEDGFLLLEGFFTADECVVMQQRIGEIVAEMDVPLHCRTEFSTQEDEQLQTQGNTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFRSITHSPKVQALVRSLGLQIPVVVQSMYIFKQPHFGGEVSPHQDATFLYTEPLGRVLGLWIATEDAMLENGCLWFIPGSHTSGVSRRMIRAPSDSGPGTSFLGSEPAWDNNLFVPLPVRRGGLVLIHGEVVHKSEQNLSDHSRQAYTFHLMEAAGTVWSPGNWLQPTTELPFPPLYI", "length": 291 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SRE7-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "PHYHD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACLSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLYT", "length": 291 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5U3U0-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "phyhd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDVLTDQDVQKFRDEGYLVLEGLLSPEECDALRRRMSEIIESMDVPEHCRTQFSTDHDEQLKTQGNADYFITSGDKIRFFFEKGVFDDKGEFVVPKEQSLNKIGHALHAYEPLFKRVTHSPKVQNICKKLELINPVILQSMYIFKQPGIGGEVTPHQDATFLYTQPLGRVMGVWVALEDAMQENGCLWFIPGSHNDGITRRMVRTPKGTFPLTDFIGREKDYDDKLFVPAPVKKGGAVLIHGEVVHRSAANTSDASRHVYTFHIMESENTVWSPENWLQATEELPFPSLYT", "length": 291 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9DB26-1", "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "Phyhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACLSPSQLKKFQEDGFLLLEGFFTADECVAMQQRIGEIVAEMDVPLHCRTEFSTQEDEQLQTQGKTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFRSITHSPKVQALVRSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDATFLYTEPLGRVLGLWIAMEDAMLENGCLWFIPGSHTRGVSRRMIRAPSDSGPGTSFLGSDPAWASNLFVPLPVRRGGLVLIHGEVVHKSEQNHSDHSRQAYTVHLMEAAGTVWSPGNWLQPTPELPFPPLYS", "length": 291 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VGY8-1", "protein_name": "1.14.11.-", "gene_name": "Phyhd1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHSKLLDELNENGYIVIEDFLTAEEVDSLYQAGRALCLDAPQNNRKIFSTIKQEDAQGKELYFMESGDKVRYFFEKGAVGDEGQLLVDPMIALNKVGHALHVEHPAFNAITFSNRVREICWQLNYNKPAVCQSMYIYKNPGVGGEVTPHQDSWFLHTDPNSAVGFWLALEDCTLQNGCLQFIKGSHKSGVHRRYLRNPDKDASELMVYDRAAPIYPQSSFTPMQVSKGTCILIHGNVVHKSEPNRSQKSRHAYTFHVIETENNVKYSEDNWLQAPKDKPFPVLFERKA", "length": 288 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZVF6-1", "protein_name": "Phytanoyl-CoA dioxygenase", "gene_name": "PAHX", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGITGSLTPDQLDFFHSQGYLVIESFASEDEIRGLRKRMDELLNQFDCSVSSIFSTKNQKHTTDNYFFESAEKISFFFEEKAFGDDGKLKQPKQLSINKVGHALHELDPLYKDFTYSSKFSSLASSLGYRRPVVMQSMYIFKQPGIGGEVVPHQDNSFVYTDPQSCTGLWIALEDSTLVNGCLWAIPGSHKNGLVRRFIRGDNGITFDQPSPSYEQKDFVSIEMKAGSLIAIHGDLIHQSFENLSSKSRHAYSLHVVESDGCKWAKDNWIQRAKMPEPLYVLP", "length": 283 }, "evidence": [ { "id": "A0AAA9T328", "url": "https://omabrowser.org/oma/group/A0AAA9T328/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T328", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328" } ], "pmid": "" }, { "name": "2-oxoglutarate-dependent dioxygenase activity", "id": "GO:0016706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T328", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T328" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4K6-1", "uniprot_ac": "A0AAA9T4K6", "uniprot_id": "A0AAA9T4K6_BOVIN", "mass": { "chemical_mass": 53720.0, "monoisotopic_mass": 53720.0 }, "refseq": { "ac": "XP_005204146", "name": "DENN domain-containing protein 2D isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204146" }, "gene_names": [ { "name": "DENND2D", "type": "recommended", "evidence": [ { "id": "A0AAA9T4K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" } ] }, { "name": "DENND2D", "type": "synonym", "evidence": [ { "id": "XP_005204146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204146" } ] } ], "protein_names": [ { "name": "DENN domain containing 2D", "type": "synonym", "evidence": [ { "id": "A0AAA9T4K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6/entry#names_and_taxonomy" } ] }, { "name": "DENN domain-containing protein 2D isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005204146", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204146" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND2D", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6", "locus": { "chromosome": "3", "start_pos": 32224612, "end_pos": 32204928, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020172", "url": "https://www.ensembl.org/id/ENSBTAG00000020172" } ] } } ], "crossref": [ { "id": "A0AAA9T4K6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4K6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020172", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020172", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504595", "url": "https://www.ncbi.nlm.nih.gov/gene/504595", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SEEFNTH", "url": "https://omabrowser.org/oma/group/SEEFNTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M253", "url": "https://www.orthodb.org/?gene=A0A3Q1M253", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1V1", "url": "https://www.orthodb.org/?gene=F1N1V1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15288:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15288:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005204146", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204146", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M253", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M253", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M253-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M253-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1V1", "url": "https://www.uniprot.org/uniprotkb/F1N1V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1V1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1V1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGLGRRLRASLRLKRGRWGPPQENLGEVVKEPERALEHCLPNFAGGQHFFEYLLVVSLKRKHSGEDYEPRIIYQFPKRENLLRGQQEEEDRLLGAIPLFCFPDGNERAPLTECPRETFSFVLTNVDGSRKIGYCRRLLPDGHGPRLPRVYCIISCIGCFGLFSKILDEVEKRHQISMAIIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFRSLMRCLSFEQILQIFASAVLERRIIFLAEGLSTLSQCIHATAALLYPFSWAHTYIPVVPESLLGTVCCPTPFMVGVQMRFRQEVLDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILESLSQGIKESQTSEQINEHVSRPFVQFFVKTVGHYASYIKREANGQGRFQERAFYKALTSKANRRFVKKFVKTQLFSLFIQEAEKSKNPPADYFQKKIREYEEQKKQKKPKEKTVK", "length": 468, "header": "tr|A0AAA9T4K6-1|A0AAA9T4K6_BOVIN Isoform 1 of DENN domain containing 2D OS=Bos taurus OX=9913 GN=DENND2D PE=4 SV=1 CANONICAL=A0AAA9T4K6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M253-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6/entry#A0A3Q1M253-1", "sequence": { "sequence": "MDGLGRRLRASLRLKRGRWGPPQENLGEVVKEPERALEHCLPNFAGGQHFFEYLLVVSLKRKHSGEDYEPRIIYQFPKRENLLRGQQEEEDRLLGAIPLFCFPDGNERAPLTECPRETFSFVLTNVDGSRKIGYCRRLLPDGHGPRLPRVYCIISCIGCFGLFSKILDEVEKRHQISMAIIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFRSLMRCLSFEQILQIFASAVLERRIIFLAEGLSTLSQCIHATAALLYPFSWAHTYIPVVPESLLGTVCCPTPFMVGVQMRFRQEVLDSPMEEVGDEKDILPPKLQDDILESLSQGIKESQTSEQINEHVSRPFVQFFVKTVGHYASYIKREANGQGRFQERAFYKALTSKANRRFVKKFVKTQLFSLFIQEAEKSKNPPADYFQKKIREYEEQKKQKKPKEKTVK", "length": 454, "header": "tr|A0A3Q1M253-1|A0AAA9T4K6_BOVIN Computationally mapped isoform of DENN domain containing 2D OS=Bos taurus OX=9913 GN=DENND2D PE=4 SV=2 CANONICAL=A0AAA9T4K6-1" }, "locus": { "chromosome": "3", "start_pos": 32224169, "end_pos": 32205127, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070142.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070142.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064076.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064076.2" } ] } }, { "isoform_ac": "A0AAA9T4K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6/entry#A0AAA9T4K6-1", "sequence": { "sequence": "MDGLGRRLRASLRLKRGRWGPPQENLGEVVKEPERALEHCLPNFAGGQHFFEYLLVVSLKRKHSGEDYEPRIIYQFPKRENLLRGQQEEEDRLLGAIPLFCFPDGNERAPLTECPRETFSFVLTNVDGSRKIGYCRRLLPDGHGPRLPRVYCIISCIGCFGLFSKILDEVEKRHQISMAIIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFRSLMRCLSFEQILQIFASAVLERRIIFLAEGLSTLSQCIHATAALLYPFSWAHTYIPVVPESLLGTVCCPTPFMVGVQMRFRQEVLDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILESLSQGIKESQTSEQINEHVSRPFVQFFVKTVGHYASYIKREANGQGRFQERAFYKALTSKANRRFVKKFVKTQLFSLFIQEAEKSKNPPADYFQKKIREYEEQKKQKKPKEKTVK", "length": 468, "header": "tr|A0AAA9T4K6-1|A0AAA9T4K6_BOVIN Isoform 1 of DENN domain containing 2D OS=Bos taurus OX=9913 GN=DENND2D PE=4 SV=1 CANONICAL=A0AAA9T4K6-1" }, "locus": { "chromosome": "3", "start_pos": 32224169, "end_pos": 32205127, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097161.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097161.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092739.1" } ] } }, { "isoform_ac": "F1N1V1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6/entry#F1N1V1-1", "sequence": { "sequence": "MPDRPKKMERQAGGGILSRFRKRLPLHRAGPPQENLGEVVKEPERALEHCLPNFAGGQHFFEYLLVVSLKRKHSGEDYEPRIIYQFPKRENLLRGQQEEEDRLLGAIPLFCFPDGNERAPLTECPRETFSFVLTNVDGSRKIGYCRRLLPDGHGPRLPRVYCIISCIGCFGLFSKILDEVEKRHQISMAIIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFRSLMRCLSFEQILQIFASAVLERRIIFLAEGLSTLSQCIHATAALLYPFSWAHTYIPVVPESLLGTVCCPTPFMVGVQMRFRQEVLDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILESLSQGIKESQTSEQINEHVSRPFVQFFVKTVGHYASYIKREANGQGRFQERAFYKALTSKANRRFVKKFVKTQLFSLFIQEAEKSKNPPADYFQKKIREYEEQKKQKKPKEKTVK", "length": 478, "header": "tr|F1N1V1-1|A0AAA9T4K6_BOVIN Computationally mapped isoform of DENN domain containing 2D OS=Bos taurus OX=9913 GN=DENND2D PE=4 SV=2 CANONICAL=A0AAA9T4K6-1" }, "locus": { "chromosome": "3", "start_pos": 32224169, "end_pos": 32209085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026865.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026865.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026865.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026865.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [ { "uniprot_canonical_ac": "Q91VV4-1", "protein_name": "DENN domain-containing protein 2D", "gene_name": "Dennd2d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGQGVGRTLRLLRNRLPRLRAGQSQNNPGEAVTEPERIQEHSPSSFAGGQHFFEYLLVVSLKKKRLGDDYEPTITYQFPKRENLLRGQQEEEDRLLSAIPLFCFPDGNEWAPLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPQLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSVLLHCLHLEQIIQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFLQEVMDSPMEEVLLVNLCEGTFLLSVGDEKDILPPKLQDDILDSLGQGINELKTSEQINEHVSGPFVQFFVKTVGHYASYIKREASGQGHFQERSFCKAVTSKTKRRFVKKFVKTQLFSLFIQEAEKSRNPPAGYFQKKILEYEEQKKQKKSRERL", "length": 469 }, "evidence": [ { "id": "A0AAA9T4K6", "url": "https://omabrowser.org/oma/group/A0AAA9T4K6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H6A0-1", "protein_name": "DENN domain-containing protein 2D", "gene_name": "DENND2D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK", "length": 471 }, "evidence": [ { "id": "A0AAA9T4K6", "url": "https://omabrowser.org/oma/group/A0AAA9T4K6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4K6" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 442, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4P8-1", "uniprot_ac": "A0AAA9T4P8", "uniprot_id": "A0AAA9T4P8_BOVIN", "mass": { "chemical_mass": 62674.0, "monoisotopic_mass": 62674.0 }, "refseq": {}, "gene_names": [ { "name": "PDE7A", "type": "recommended", "evidence": [ { "id": "A0AAA9T4P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ] } ], "protein_names": [ { "name": "Phosphodiesterase", "type": "recommended", "evidence": [ { "id": "A0AAA9T4P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.-", "type": "synonym", "evidence": [ { "id": "A0AAA9T4P8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDE7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8", "locus": { "chromosome": "14", "start_pos": 30104450, "end_pos": 30213098, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011614", "url": "https://www.ensembl.org/id/ENSBTAG00000011614" } ] } } ], "crossref": [ { "id": "A0AAA9T4P8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4P8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100849042", "url": "https://www.ncbi.nlm.nih.gov/gene/100849042", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100849042", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100849042", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00233", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00233", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "25277", "url": "https://www.rhea-db.org/rhea/25277", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SAX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGIQGGKHGGDPAVRAERCDWAACLGFPKRKGRNRASRVGGAHPTPSARAPTLEFSDKGEYPHTVGPRAHAPWPGWWSAAGRGPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 552, "header": "tr|A0AAA9T4P8-1|A0AAA9T4P8_BOVIN Isoform 1 of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9SAX6-1", "sequence": { "sequence": "MVSEPRGAAPGEGGSTPPPLARLPRRCGGAGPAARRRDVTVAAAVVGAGSAAAKCELRRARAGGGVKPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 536, "header": "tr|A0AAA9SAX6-1|A0AAA9T4P8_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30212624, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132767.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132767.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083253.1" } ] } }, { "isoform_ac": "A0AAA9SC79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9SC79-1", "sequence": { "sequence": "MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 455, "header": "tr|A0AAA9SC79-1|A0AAA9T4P8_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30211919, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113474.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113474.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081130.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081130.1" } ] } }, { "isoform_ac": "A0AAA9SXI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9SXI8-1", "sequence": { "sequence": "MGITLIWCLALVLIKWVASKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 457, "header": "tr|A0AAA9SXI8-1|A0AAA9T4P8_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30162307, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091186.1" } ] } }, { "isoform_ac": "A0AAA9T4P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9T4P8-1", "sequence": { "sequence": "MGIQGGKHGGDPAVRAERCDWAACLGFPKRKGRNRASRVGGAHPTPSARAPTLEFSDKGEYPHTVGPRAHAPWPGWWSAAGRGPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 552, "header": "tr|A0AAA9T4P8-1|A0AAA9T4P8_BOVIN Isoform 1 of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30212902, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090034.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090034.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090699.1" } ] } }, { "isoform_ac": "A0AAA9TLH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9TLH1-1", "sequence": { "sequence": "MRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 438, "header": "tr|A0AAA9TLH1-1|A0AAA9TLH1_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30181526, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119420.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119420.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098055.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098055.1" } ] } }, { "isoform_ac": "A0AAA9TNN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9TNN3-1", "sequence": { "sequence": "MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQPSSEDADAAFEELSSQLLPQENRLP", "length": 483, "header": "tr|A0AAA9TNN3-1|A0AAA9TNN3_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30211919, "end_pos": 30107417, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100153.1" } ] } }, { "isoform_ac": "A0AAA9TSX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9TSX2-1", "sequence": { "sequence": "MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIGRSPWEAKLQSAGYLRMDSEPGKQGPSRIL", "length": 444, "header": "tr|A0AAA9TSX2-1|A0AAA9TSX2_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30211919, "end_pos": 30104565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105741.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105741.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101709.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101709.1" } ] } }, { "isoform_ac": "A0AAA9TXL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8/entry#A0AAA9TXL3-1", "sequence": { "sequence": "MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHAQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTTVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDVLLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHMPLESRQQMEAQIGALILATDISRQNEYLSLFRAHLDKGDLHLEDARHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRQTESIANIQIEHSSWQAHLDYSLLSPGQPKAVLGIE", "length": 440, "header": "tr|A0AAA9TXL3-1|A0AAA9TXL3_BOVIN Computationally mapped isoform of Phosphodiesterase OS=Bos taurus OX=9913 GN=PDE7A PE=3 SV=1 CANONICAL=A0AAA9T4P8-1" }, "locus": { "chromosome": "14", "start_pos": 30211919, "end_pos": 30109095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113760.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113760.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103397.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 45, "start_aa": "Thr", "end_pos": 45, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr45", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100849042", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100849042", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ], "pmid": "" }, { "name": "3',5'-cyclic-AMP phosphodiesterase activity", "id": "GO:0004115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4P8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25277", "name": "", "equation": "3',5'-cyclic AMP + H2O = AMP + H(+)", "summary": "", 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"LQQLLQQDPAYDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKLMHQAALLGQALTDSRKFGWEYMRHSWATMTEAIQSHIGSLSWGHRLALREKAVTYVNSFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLFSLPYCPGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQQLGVRFLRKFVPVEQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGLEKIGVNVSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRSEKCDYVNVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDNNTCYAKIICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVRPLGLRGRGGPSLGRSLFPPKQTPQPHAQGSRRQCGPGLPSSHWPTGPLVRTSFLKKL", "length": 531, "header": "tr|A0AAA9T4F0-1|A0AAA9T4F0_BOVIN Isoform 1 of thioredoxin-disulfide reductase (NADPH) OS=Bos taurus OX=9913 GN=TXNRD3 PE=3 SV=1 CANONICAL=A0AAA9T4F0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F0/entry#A0AAA9T4F0-1", "sequence": { "sequence": "LQQLLQQDPAYDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKLMHQAALLGQALTDSRKFGWEYMRHSWATMTEAIQSHIGSLSWGHRLALREKAVTYVNSFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLFSLPYCPGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQQLGVRFLRKFVPVEQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGLEKIGVNVSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRSEKCDYVNVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDNNTCYAKIICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVRPLGLRGRGGPSLGRSLFPPKQTPQPHAQGSRRQCGPGLPSSHWPTGPLVRTSFLKKL", "length": 531, "header": "tr|A0AAA9T4F0-1|A0AAA9T4F0_BOVIN Isoform 1 of thioredoxin-disulfide reductase (NADPH) OS=Bos taurus OX=9913 GN=TXNRD3 PE=3 SV=1 CANONICAL=A0AAA9T4F0-1" }, "locus": { "chromosome": "22", "start_pos": 60442843, "end_pos": 60422224, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114407.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114407.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092681.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 469, "start_aa": "Thr", "end_pos": 469, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr469", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thioredoxin-disulfide reductase (NADPH) activity", "id": "GO:0004791", "url": 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Process", "total": 2, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F0" } ], "pmid": "" }, { "name": "cell redox homeostasis", "id": "GO:0045454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4F0", "database": "UniProtKB", "url": 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+ NADPH + H(+).", "evidence": [ { "id": "1.8.1.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9" }, { "id": "1.8.1.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.1.9" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 469 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 413, "end_pos": 415 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T406-1", "uniprot_ac": "A0AAA9T406", "uniprot_id": "A0AAA9T406_BOVIN", "mass": { "chemical_mass": 19904.0, "monoisotopic_mass": 19904.0 }, "refseq": {}, "gene_names": [ { "name": "SNCA", "type": "recommended", "evidence": [ { "id": "A0AAA9T406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ] } ], "protein_names": [ { "name": "Alpha-synuclein", "type": "recommended", "evidence": [ { "id": "A0AAA9T406", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TJD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD0#function" }, { "database": "UniProtKB", "id": "ARBA00056203", "url": "https://www.uniprot.org/uniprotkb/ARBA00056203#function" }, { "database": "UniProtKB", "id": "A0AAF6Z2F7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2F7#function" }, { "database": "UniProtKB", "id": "A0AAF7A1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A1L9#function" }, { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406#function" }, { "database": "UniProtKB", "id": "A0AAA9SQE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE3#function" }, { "database": "UniProtKB", "id": "A0AAA9TGJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ4#function" }, { "database": "UniProtKB", "id": "A0AAA9TI69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI69#function" }, { "database": "UniProtKB", "id": "A0AAA9S1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S7#function" }, { "database": "UniProtKB", "id": "A0AAA9SEJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEJ8#function" }, { "database": "UniProtKB", "id": "A0AAA9TAD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNCA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406", "locus": { "chromosome": "6", "start_pos": 35032295, "end_pos": 34853388, "strand": "-", "evidence": [ { "database": 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"Protein Classification", "Other" ] }, { "id": "A0AAA9S1S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQE3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T406-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2F7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A1L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF7A1L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF7A1L9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKIEKGTPPAASAFCARMTALKCVSSARNVTVFSCKKIRGRERLPAEEQCVVSHHLDSSAMCNSEWYWLRQQASSLISSGILQQYRCH", "length": 188, "header": "tr|A0AAA9T406-1|A0AAA9T406_BOVIN Isoform 1 of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9S1S7-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGEEGASQEGILEDMPVDPDNEAYEMPSEMHKLARSRTSSVWTTCK", "length": 147, "header": "tr|A0AAA9S1S7-1|A0AAA9T406_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=2 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34997713, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119870.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119870.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076039.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076039.2" } ] } }, { "isoform_ac": "A0AAA9SEJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9SEJ8-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKAETQETDVVRTLTFYQSFQDLSAIAAMEHRMSSQRRAPHWVPDYWGGNIFLLFIIGSLVGLVTKF", "length": 167, "header": "tr|A0AAA9SEJ8-1|A0AAA9T406_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34993049, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113306.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113306.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082030.1" } ] } }, { "isoform_ac": "A0AAA9SQE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9SQE3-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGLPTWLSGKKSACQCRRLRRHNFGPWVWKIPGGRSGNPLQNSFLETHYRGTWWSTVHGVAESDMT", "length": 167, "header": "tr|A0AAA9SQE3-1|A0AAA9T406_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34943672, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130135.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130135.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088553.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088553.1" } ] } }, { "isoform_ac": "A0AAA9T406-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9T406-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKIEKGTPPAASAFCARMTALKCVSSARNVTVFSCKKIRGRERLPAEEQCVVSHHLDSSAMCNSEWYWLRQQASSLISSGILQQYRCH", "length": 188, "header": "tr|A0AAA9T406-1|A0AAA9T406_BOVIN Isoform 1 of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34888262, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110660.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110660.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091232.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091232.1" } ] } }, { "isoform_ac": "A0AAA9TAD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9TAD5-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGEEGASQEGILEDMPVDPDNEAYEMPSEADETIKKKIVLDVGE", "length": 145, "header": "tr|A0AAA9TAD5-1|A0AAA9TAD5_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=2 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34999591, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132354.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132354.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092954.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092954.2" } ] } }, { "isoform_ac": "A0AAA9TGJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9TGJ4-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKLTGLCLCTAAAAAKLLQSCPTLCDPRDSSPPGSPVPGILQARTLEWVAISFSNALK", "length": 158, "header": "tr|A0AAA9TGJ4-1|A0AAA9TGJ4_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34880030, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101166.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101166.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096169.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096169.1" } ] } }, { "isoform_ac": "A0AAA9TI69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9TI69-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKFSRSFPPHAHLRLKEILLLLSHFSRVRLCATP", "length": 134, "header": "tr|A0AAA9TI69-1|A0AAA9TI69_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34937976, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099317.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099317.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097982.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097982.1" } ] } }, { "isoform_ac": "A0AAA9TJD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAA9TJD0-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKHTMESPHAHGDKSHNILVVETQEHKKTCT", "length": 131, "header": "tr|A0AAA9TJD0-1|A0AAA9T406_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34877817, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091206.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091206.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097028.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097028.1" } ] } }, { "isoform_ac": "A0AAF6Z2F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAF6Z2F7-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGEEGASQEGILEDMPVDPDNEAYEMPSEPPCCEEAGTRRAICKCCH", "length": 148, "header": "tr|A0AAF6Z2F7-1|A0AAF6Z2F7_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 35032292, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021300.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021300.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021300.4", "url": "https://www.ensembl.org/id/ENSBTAP00000021300.4" } ] } }, { "isoform_ac": "A0AAF7A1L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406/entry#A0AAF7A1L9-1", "sequence": { "sequence": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGRTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGEAVVTGVTAVAQKTVEGAGSIAAATGFGKKDHMGKGEEGASQEGILEDMPVDPDNEAYEMPSEVRIYTHKTPNRKVEI", "length": 145, "header": "tr|A0AAF7A1L9-1|A0AAF7A1L9_BOVIN Computationally mapped isoform of Alpha-synuclein OS=Bos taurus OX=9913 GN=SNCA PE=3 SV=1 CANONICAL=A0AAA9T406-1" }, "locus": { "chromosome": "6", "start_pos": 34998011, "end_pos": 34854945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066780.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066780.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061053.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061053.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 20, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "supramolecular fiber", "id": "GO:0099512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "platelet alpha granule membrane", "id": "GO:0031092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031092", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "Lewy body", "id": "GO:0097413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097413", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 24, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "enzyme activator activity", "id": "GO:0008047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T406" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T406", "url": 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"UniProtKB", "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDKN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455", "locus": { "chromosome": "10", "start_pos": 66942924, "end_pos": 66925160, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019496", "url": "https://www.ensembl.org/id/ENSBTAG00000019496" } ] } } ], "crossref": [ { "id": "A0AAA9T455", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T455", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019496", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019496", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14505", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14505", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615282", "url": "https://www.ncbi.nlm.nih.gov/gene/615282", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022778", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022778", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEV5", "url": "https://www.orthodb.org/?gene=A0A3Q1MEV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23339", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23339", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05706", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05706", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MEV5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEV5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3F7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3F7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3F7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T455-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERNRPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRNSLSRSVSR", "length": 215, "header": "tr|A0AAA9T455-1|A0AAA9T455_BOVIN Isoform 1 of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=1 CANONICAL=A0AAA9T455-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0A3Q1MEV5-1", "sequence": { "sequence": "MKPPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKDPPFQFHSVLGMNSVTW", "length": 201, "header": "tr|A0A3Q1MEV5-1|A0A3Q1MEV5_BOVIN Computationally mapped isoform of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=2 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66938448, "end_pos": 66925264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068984.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068984.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069040.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069040.2" } ] } }, { "isoform_ac": "A0AAA9S3F7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0AAA9S3F7-1", "sequence": { "sequence": "VEGLARLGAEAEIPVLPKRGGGRSGRGVARNEAGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRNSLSRSVSR", "length": 196, "header": "tr|A0AAA9S3F7-1|A0AAA9T455_BOVIN Computationally mapped isoform of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=2 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66941848, "end_pos": 66925173, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132741.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132741.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080471.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080471.2" } ] } }, { "isoform_ac": "A0AAA9T455-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0AAA9T455-1", "sequence": { "sequence": "MAERNRPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRNSLSRSVSR", "length": 215, "header": "tr|A0AAA9T455-1|A0AAA9T455_BOVIN Isoform 1 of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=1 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66941848, "end_pos": 66925431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117666.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117666.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091288.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091288.1" } ] } }, { "isoform_ac": "A0AAA9TL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0AAA9TL15-1", "sequence": { "sequence": "MKPPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHSCLSPPIPVGHSITTASHRQPEGPERIWSDTDHKTI", "length": 175, "header": "tr|A0AAA9TL15-1|A0AAA9T455_BOVIN Computationally mapped isoform of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=1 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66941769, "end_pos": 66925264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096322.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096322.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099135.1" } ] } }, { "isoform_ac": "A0AAA9TRU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0AAA9TRU6-1", "sequence": { "sequence": "MKPPSSMQTSCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRNSLSRSVSR", "length": 172, "header": "tr|A0AAA9TRU6-1|A0AAA9T455_BOVIN Computationally mapped isoform of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=2 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66941848, "end_pos": 66925264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128796.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128796.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101097.2", "url": "https://www.ensembl.org/id/ENSBTAP00000101097.2" } ] } }, { "isoform_ac": "A0AAA9TT12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455/entry#A0AAA9TT12-1", "sequence": { "sequence": "MKPPSSMQTSEFDSSDEEPIEDEQTPIQISWLPLSRVNCSQFLGLCALPGCKFKDVRRNIQKDTEELKSYGIQDIFVFCTRGELSKYRVPNLLDLYHQYGIITHHHPIPDGGTPDITSCCEIMEELEICLKNNRKTLIHCYGGLGRSCLVAACLLLYLSDTVSPQQAIDSLRDLRGSGAIQTIKQCPKDITDL", "length": 193, "header": "tr|A0AAA9TT12-1|A0AAA9T455_BOVIN Computationally mapped isoform of Cyclin-dependent kinase inhibitor 3 OS=Bos taurus OX=9913 GN=CDKN3 PE=3 SV=1 CANONICAL=A0AAA9T455-1" }, "locus": { "chromosome": "10", "start_pos": 66938702, "end_pos": 66925264, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126410.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126410.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101748.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 116, "start_aa": "Thr", "end_pos": 116, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr116", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T455", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 41, "end_pos": 43, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], 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H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", 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"url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": 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"url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQP9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGSLQAWASSLCPPENPPGLSSSQDTASPHRNLWVPGQPLQHCPWPAGLPYQAWRPSSLEAGTPGKALNEEGLSPAGGRKPSSVNPNLCHPDGTVDRKPVCTDSPQPSPSR", "length": 426, "header": "tr|A0AAA9T2Q5-1|A0AAA9T2Q5_BOVIN Isoform 1 of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=1 CANONICAL=A0AAA9T2Q5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0A3Q1LZ47-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLQVVQADIASIDSDAVVHPTNTDFYTGGEVGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN", "length": 369, "header": "tr|A0A3Q1LZ47-1|A0A3Q1LZ47_BOVIN Computationally mapped isoform of Core histone macro-H2A OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=2 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46801264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085829.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085829.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060958.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060958.2" } ] } }, { "isoform_ac": "A0AAA9SEI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAA9SEI5-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRSGAKPPICSILTAIPQGTVFRSRRQLS", "length": 344, "header": "tr|A0AAA9SEI5-1|A0AAA9T2Q5_BOVIN Computationally mapped isoform of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=2 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46801395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104003.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104003.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082259.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082259.2" } ] } }, { "isoform_ac": "A0AAA9T2Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAA9T2Q5-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGSLQAWASSLCPPENPPGLSSSQDTASPHRNLWVPGQPLQHCPWPAGLPYQAWRPSSLEAGTPGKALNEEGLSPAGGRKPSSVNPNLCHPDGTVDRKPVCTDSPQPSPSR", "length": 426, "header": "tr|A0AAA9T2Q5-1|A0AAA9T2Q5_BOVIN Isoform 1 of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=1 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46805596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089942.1" } ] } }, { "isoform_ac": "A0AAA9TLZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAA9TLZ5-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN", "length": 372, "header": "tr|A0AAA9TLZ5-1|A0AAA9T2Q5_BOVIN Computationally mapped isoform of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=1 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46801264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108319.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108319.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098266.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098266.1" } ] } }, { "isoform_ac": "A0AAA9TQP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAA9TQP9-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRSGAKPPICSILTAIPQGISGSLVSLFSTAPGLQACLTRPGGQAHWKQGRLAKP", "length": 370, "header": "tr|A0AAA9TQP9-1|A0AAA9TQP9_BOVIN Computationally mapped isoform of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=1 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46805727, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099635.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099635.1" } ] } }, { "isoform_ac": "A0AAA9TQX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAA9TQX5-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKLDAN", "length": 200, "header": "tr|A0AAA9TQX5-1|A0AAA9TQX5_BOVIN Computationally mapped isoform of Histone H2A OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=1 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46801264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128132.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128132.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099728.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099728.1" } ] } }, { "isoform_ac": "A0AAF6DLJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5/entry#A0AAF6DLJ4-1", "sequence": { "sequence": "MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVSKKTGGKKGARKSKKQGEVSKAASADSTTEGTPADGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPIWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRYQSLGHPAHTESLAGSLPSVPPNT", "length": 341, "header": "tr|A0AAF6DLJ4-1|A0AAF6DLJ4_BOVIN Computationally mapped isoform of MacroH2A.1 histone OS=Bos taurus OX=9913 GN=MACROH2A1 PE=1 SV=2 CANONICAL=A0AAA9T2Q5-1" }, "locus": { "chromosome": "7", "start_pos": 46871830, "end_pos": 46808802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021436.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021436.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021436.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021436.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "Barr body", "id": "GO:0001740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "structural constituent of chromatin", "id": "GO:0030527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "rDNA binding", "id": "GO:0000182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000182", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "double-stranded methylated DNA binding", "id": "GO:0010385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010385", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "nucleosomal DNA binding", "id": "GO:0031492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031492", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "ADP-D-ribose modification-dependent protein binding", "id": "GO:0160002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160002", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "regulation of lipid metabolic process", "id": "GO:0019216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019216", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "regulation of oxidative phosphorylation", "id": "GO:0002082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "negative regulation of cell cycle G2/M phase transition", "id": "GO:1902750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "positive regulation of keratinocyte differentiation", "id": "GO:0045618", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045618", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "establishment of protein localization to chromatin", "id": "GO:0071169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "negative regulation of transcription of nucleolar large rRNA by RNA polymerase I", "id": "GO:1901837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q5" } ], "pmid": "" }, { "name": "positive regulation of maintenance of mitotic sister chromatid 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"database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012346", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012346", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013711", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013711", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027384", "url": 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0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2T0-1", "uniprot_ac": "A0AAA9T2T0", "uniprot_id": "A0AAA9T2T0_BOVIN", "mass": { "chemical_mass": 83689.0, "monoisotopic_mass": 83689.0 }, "refseq": { "ac": "XP_010812389", "name": "activating signal cointegrator 1 complex subunit 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812389" }, "gene_names": [ { "name": "ASCC2", "type": "recommended", "evidence": [ { "id": "A0AAA9T2T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ] }, { "name": "ASCC2", "type": "synonym", "evidence": [ { "id": "XP_010812389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812389" } ] } ], "protein_names": [ { "name": "Activating signal cointegrator 1 complex subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T2T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#names_and_taxonomy" } ] }, { "name": "activating signal cointegrator 1 complex subunit 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010812389", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812389" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASCC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0", "locus": { "chromosome": "17", "start_pos": 68906701, "end_pos": 68942865, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002452", "url": "https://www.ensembl.org/id/ENSBTAG00000002452" } ] } } ], "crossref": [ { "id": "A0AAA9T2T0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2T0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002452", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002452", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14364", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14364", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505503", "url": "https://www.ncbi.nlm.nih.gov/gene/505503", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MNT9", "url": "https://www.orthodb.org/?gene=F1MNT9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2K6", "url": "https://www.orthodb.org/?gene=F1N2K6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21494", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21494", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21494:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21494:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02845", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02845", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010812389", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812389", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZD3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZD3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNT9", "url": "https://www.uniprot.org/uniprotkb/F1MNT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNT9-1", "url": "https://www.uniprot.org/uniprotkb/F1MNT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2K6", "url": "https://www.uniprot.org/uniprotkb/F1N2K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2K6-1", "url": "https://www.uniprot.org/uniprotkb/F1N2K6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPAVLPASLRRAAQHNARLASGSTPGHPRGPEDRKAEDFACAVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDRQVKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEESARSLLNDKREVQAQRQRFEQYSVVVEEVPLQPGEGSPYRGDDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTRVPGEGQEDEEEEEEEATVEAPKPDHFVQDPAVLREKAEARRVAFLARKGYRHDSSTVVAGSPRGHGQSRETMQERRKKEASKATRANHNRRTMADRKRSKGMIPS", "length": 739, "header": "tr|A0AAA9T2T0-1|A0AAA9T2T0_BOVIN Isoform 1 of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=1 CANONICAL=A0AAA9T2T0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#A0A3Q1LZD3-1", "sequence": { "sequence": "MPALPLDRLQVTHEDLKTGKLRTSPALVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDRQVKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEESARSLLNDKREVQAQRQRFEQYSVVVEEVPLQPGEGSPYRGDDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTRVPGEGQEDEEEEEEEATVEAPKPDHFVQDPAVLREKAEARRVAFLARKGYRHDSSTVVAGSPRGHGQSRETMQERRKKEASKATRANHNRRTMADRKRSKGMIPS", "length": 694, "header": "tr|A0A3Q1LZD3-1|A0AAA9T2T0_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=1 CANONICAL=A0AAA9T2T0-1" }, "locus": { "chromosome": "17", "start_pos": 68937922, "end_pos": 68907065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081841.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081841.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062998.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062998.2" } ] } }, { "isoform_ac": "A0AAA9S0F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#A0AAA9S0F0-1", "sequence": { "sequence": "MANKHPEQKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDRQVKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEESARSLLNDKREVQAQRQRFEQYSVVVEEVPLQPGEGSPYRGDDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTRVPGEGQEDEEEEEEEATVEAPKPDHFVQDPAVLREKAEARRVAFLARKGYRHDSSTVVAGSPRGHGQSRETMQERRKKEASKATRANHNRRTMADRKRSKGMIPS", "length": 724, "header": "tr|A0AAA9S0F0-1|A0AAA9T2T0_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=1 CANONICAL=A0AAA9T2T0-1" }, "locus": { "chromosome": "17", "start_pos": 68933754, "end_pos": 68907065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115598.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115598.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079321.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079321.1" } ] } }, { "isoform_ac": "A0AAA9T2T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#A0AAA9T2T0-1", "sequence": { "sequence": "MFPAVLPASLRRAAQHNARLASGSTPGHPRGPEDRKAEDFACAVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDRQVKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEESARSLLNDKREVQAQRQRFEQYSVVVEEVPLQPGEGSPYRGDDYEDEYDDTYDGNQVGANDADSDDELISRRPFTIPQVLRTRVPGEGQEDEEEEEEEATVEAPKPDHFVQDPAVLREKAEARRVAFLARKGYRHDSSTVVAGSPRGHGQSRETMQERRKKEASKATRANHNRRTMADRKRSKGMIPS", "length": 739, "header": "tr|A0AAA9T2T0-1|A0AAA9T2T0_BOVIN Isoform 1 of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=1 CANONICAL=A0AAA9T2T0-1" }, "locus": { "chromosome": "17", "start_pos": 68940336, "end_pos": 68907065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123373.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123373.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090757.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090757.1" } ] } }, { "isoform_ac": "F1MNT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#F1MNT9-1", "sequence": { "sequence": "MPALPLDRLQVTHEDLKTGKLRTSPALHPEQKADRYFVLYKPPPKDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDRQVKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGRRKEESARSLLNDKREVQAQRQRFEQYSVVVEEVPLQPGEGSPYRGDDYEDEYDDTYDGNQVGANDADSDDELISRSPTTLCRTLRCYGRKRKPDVWPSWPGRGTGMTAPQWWPAAPGATGRAERPCRNAGRRKPARPPEPTTTGGPWLTAREVKA", "length": 710, "header": "tr|F1MNT9-1|A0AAA9T2T0_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=2 CANONICAL=A0AAA9T2T0-1" }, "locus": { "chromosome": "17", "start_pos": 68937922, "end_pos": 68907076, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003186.4", "url": "https://www.ensembl.org/id/ENSBTAT00000003186.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003186.3", "url": "https://www.ensembl.org/id/ENSBTAP00000003186.3" } ] } }, { "isoform_ac": "F1N2K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0/entry#F1N2K6-1", "sequence": { "sequence": "MPALPLDRLQVTHEDLKTGKLRTSPALVIFDETLQKCLDSYLRYVPRKFDEWVAPAPEVVDMQRRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPKILDLCVLFGKGNSPLLQKMIGNIFIQQPSYYNDLDETMPTILQVFSNILQHCGLRGDGASATPQKLEERGRLTPSDMPLPELKDVVLYLCDTCTTLWAFLDIFPLACPTFQKHDFCYRLASFYEIAVPELESAIKKRRLEDSKLLGDLWQRLSHSKKKLLEILHILLNQTCLLPVLENSCDNIQGFIEDFLQIFSSLLQEKRFLRDYDSLFPVADDVSLLEQASSALDETRTAYILQAVESAWEGVDRKKATRARDSATAENPNGVGAEAEVLSGPSSLPQEEKCLGAAAAPGPTVCGVELDSLISQVKDLLPDLGEGFILACLEHYSYEPEQVINNILEGRLAPTLSQLDRGLDSLQDLGSLSRD", "length": 473, "header": "tr|F1N2K6-1|A0AAA9T2T0_BOVIN Computationally mapped isoform of Activating signal cointegrator 1 complex subunit 2 OS=Bos taurus OX=9913 GN=ASCC2 PE=4 SV=1 CANONICAL=A0AAA9T2T0-1" }, "locus": { "chromosome": "17", "start_pos": 68937922, "end_pos": 68915536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044508.2", "url": "https://www.ensembl.org/id/ENSBTAT00000044508.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042000.1", "url": "https://www.ensembl.org/id/ENSBTAP00000042000.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 447, "start_aa": "Thr", "end_pos": 447, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr447", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin 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"A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ], "pmid": "" }, { "name": "ribosome-associated ubiquitin-dependent protein catabolic process", "id": "GO:1990116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2T0" } ], "pmid": "" }, { "name": "RQC-trigger complex", "id": "GO:0180022", "url": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T443-1", "uniprot_ac": "A0AAA9T443", "uniprot_id": "A0AAA9T443_BOVIN", "mass": { "chemical_mass": 15762.0, "monoisotopic_mass": 15762.0 }, "refseq": {}, "gene_names": [ { "name": "TAFA4", "type": "recommended", "evidence": [ { "id": "A0AAA9T443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ] } ], "protein_names": [ { "name": "TAFA chemokine like family member 4", "type": "synonym", "evidence": [ { "id": "A0AAA9T443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAFA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443", "locus": { "chromosome": "22", "start_pos": 32790440, "end_pos": 32581888, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003110", "url": "https://www.ensembl.org/id/ENSBTAG00000003110" } ] } } ], "crossref": [ { "id": "A0AAA9T443", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T443", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003110", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003110", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR020350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31770", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31770:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31770:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M021", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M021", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M021-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M021-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T443-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N024", "url": "https://www.uniprot.org/uniprotkb/F1N024", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N024-1", "url": "https://www.uniprot.org/uniprotkb/F1N024-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLAFKITSFEGQIEWRLHEGRNLYLCFSLYPHCLEEGLEHSHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSGWSCSSGNKVKTTKVTR", "length": 138, "header": "tr|A0AAA9T443-1|A0AAA9T443_BOVIN Isoform 1 of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=1 CANONICAL=A0AAA9T443-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M021-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#A0A3Q1M021-1", "sequence": { "sequence": "RMRACARSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHTGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEADTLLDTSVSPQGNTHRR", "length": 109, "header": "tr|A0A3Q1M021-1|A0AAA9T443_BOVIN Computationally mapped isoform of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=2 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32761404, "end_pos": 32668460, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072643.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072643.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062954.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062954.3" } ] } }, { "isoform_ac": "A0A3Q1MPJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#A0A3Q1MPJ1-1", "sequence": { "sequence": "MKSPRMRACARSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHTGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSGNTVAEREVPPRWRRDGRQRSPVGPAVLDSAGNCLRFYPRHVGIPVL", "length": 170, "header": "tr|A0A3Q1MPJ1-1|A0AAA9T443_BOVIN Computationally mapped isoform of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=2 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32789436, "end_pos": 32663367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073427.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073427.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073844.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073844.2" } ] } }, { "isoform_ac": "A0AAA9SWX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#A0AAA9SWX8-1", "sequence": { "sequence": "LFATPWTVACQGPLSTGFPRQIPDPAKTEAEAAVLVRWRDSEEGGCCWEPHTETWRPGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSGNTVAEREVPPRWRRDGRQRSPVGPAVLDSAGNCLRFYPRHVGIPVL", "length": 184, "header": "tr|A0AAA9SWX8-1|A0AAA9T443_BOVIN Computationally mapped isoform of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=1 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32789436, "end_pos": 32723496, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092081.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092081.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088752.1" } ] } }, { "isoform_ac": "A0AAA9T443-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#A0AAA9T443-1", "sequence": { "sequence": "MKLAFKITSFEGQIEWRLHEGRNLYLCFSLYPHCLEEGLEHSHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSGWSCSSGNKVKTTKVTR", "length": 138, "header": "tr|A0AAA9T443-1|A0AAA9T443_BOVIN Isoform 1 of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=1 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32789305, "end_pos": 32704987, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123289.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123289.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091425.1" } ] } }, { "isoform_ac": "A0AAA9TE93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#A0AAA9TE93-1", "sequence": { "sequence": "MKSPRMRACARSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHTGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSAPSRADLK", "length": 131, "header": "tr|A0AAA9TE93-1|A0AAA9TE93_BOVIN Computationally mapped isoform of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=1 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32782435, "end_pos": 32663367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100868.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100868.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096919.1" } ] } }, { "isoform_ac": "F1N024-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443/entry#F1N024-1", "sequence": { "sequence": "MKSPRMRACARSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHTGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMDPCLEGEDCRVLPDYSGWSCSSGNKVKTTKASIDRAQLYLAASASCNLPPPFHPAAKREGNVTLVKFRGQCPSTTRAL", "length": 185, "header": "tr|F1N024-1|A0AAA9T443_BOVIN Computationally mapped isoform of TAFA chemokine like family member 4 OS=Bos taurus OX=9913 GN=TAFA4 PE=3 SV=3 CANONICAL=A0AAA9T443-1" }, "locus": { "chromosome": "22", "start_pos": 32782310, "end_pos": 32663367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004045.8", "url": "https://www.ensembl.org/id/ENSBTAT00000004045.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004045.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004045.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" }, { "name": "macrophage chemotaxis", "id": "GO:0048246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T443", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T443" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3N2-1", "uniprot_ac": "A0AAA9T3N2", "uniprot_id": "A0AAA9T3N2_BOVIN", "mass": { "chemical_mass": 39035.0, "monoisotopic_mass": 39035.0 }, "refseq": {}, "gene_names": [ { "name": "KLF8", "type": "recommended", "evidence": [ { "id": "A0AAA9T3N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ] } ], "protein_names": [ { "name": "KLF transcription factor 8", "type": "synonym", "evidence": [ { "id": "A0AAA9T3N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2", "locus": { "chromosome": "X", "start_pos": 93446156, "end_pos": 93104296, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005852", "url": "https://www.ensembl.org/id/ENSBTAG00000005852" } ] } } ], "crossref": [ { "id": "A0AAA9T3N2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3N2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005852", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005852", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525558", "url": "https://www.ncbi.nlm.nih.gov/gene/525558", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525558", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525558", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KMTSPPF", "url": "https://omabrowser.org/oma/group/KMTSPPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2T6", "url": "https://www.orthodb.org/?gene=A0A3Q1M2T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G5E575", "url": "https://www.orthodb.org/?gene=G5E575", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M2T6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2T6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2T6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E575", "url": "https://www.uniprot.org/uniprotkb/G5E575", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E575-1", "url": "https://www.uniprot.org/uniprotkb/G5E575-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDMDQLINNWEVQLNSEGGSMHMFKQVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEPAAMTQMQEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTV", "length": 356, "header": "tr|A0AAA9T3N2-1|A0AAA9T3N2_BOVIN Isoform 1 of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=2 CANONICAL=A0AAA9T3N2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2T6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#A0A3Q1M2T6-1", "sequence": { "sequence": "MSLEDCMSSEHFRSPQLVTWVVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEREAL", "length": 249, "header": "tr|A0A3Q1M2T6-1|A0AAA9T3N2_BOVIN Computationally mapped isoform of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=2 CANONICAL=A0AAA9T3N2-1" }, "locus": { "chromosome": "X", "start_pos": 93444986, "end_pos": 93269040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071858.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071858.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067755.2" } ] } }, { "isoform_ac": "A0AAA9SRH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#A0AAA9SRH6-1", "sequence": { "sequence": "MDQLINNWEVQLNSEGGSMHMFKQVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEPAAMTQMQEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTV", "length": 353, "header": "tr|A0AAA9SRH6-1|A0AAA9T3N2_BOVIN Computationally mapped isoform of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=1 CANONICAL=A0AAA9T3N2-1" }, "locus": { "chromosome": "X", "start_pos": 93445152, "end_pos": 93319403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098932.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098932.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087954.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087954.1" } ] } }, { "isoform_ac": "A0AAA9T3N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#A0AAA9T3N2-1", "sequence": { "sequence": "MGDMDQLINNWEVQLNSEGGSMHMFKQVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEPAAMTQMQEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTV", "length": 356, "header": "tr|A0AAA9T3N2-1|A0AAA9T3N2_BOVIN Isoform 1 of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=2 CANONICAL=A0AAA9T3N2-1" }, "locus": { "chromosome": "X", "start_pos": 93445152, "end_pos": 93269099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118335.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118335.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091252.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091252.1" } ] } }, { "isoform_ac": "A0AAA9TG16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#A0AAA9TG16-1", "sequence": { "sequence": "MPLEAQNPKVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEPAAMTQMQEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTV", "length": 338, "header": "tr|A0AAA9TG16-1|A0AAA9TG16_BOVIN Computationally mapped isoform of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=1 CANONICAL=A0AAA9T3N2-1" }, "locus": { "chromosome": "X", "start_pos": 93445152, "end_pos": 93104637, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110833.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110833.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095788.1" } ] } }, { "isoform_ac": "G5E575-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2/entry#G5E575-1", "sequence": { "sequence": "MGDMDQLINNWEVQLNSEGGSMHMFKQVTGPVQIRDSLKRADRGNMTSPPLLDANSMKNPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQSPIRSPKPQPASQTLVVSTSTSDTGSSASIRTVLTPGSILASSQGTGGHQILHVIHTIPSVNLPNKMGSLKAIPVVVQSLPMVYTTLPADGNPAAITVPLIGGDGKNVGSVKVEPTSLSPLEIPSDNEENAIESGSLQGIQGLQQEREAL", "length": 255, "header": "tr|G5E575-1|G5E575_BOVIN Computationally mapped isoform of KLF transcription factor 8 OS=Bos taurus OX=9913 GN=KLF8 PE=4 SV=4 CANONICAL=A0AAA9T3N2-1" }, "locus": { "chromosome": "X", "start_pos": 93444986, "end_pos": 93269099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007694.6", "url": "https://www.ensembl.org/id/ENSBTAT00000007694.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007694.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007694.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:525558", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525558", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YJL9-1", "protein_name": "KLF transcription factor 8", "gene_name": "KLF8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRMEPSVLLVPSKRGLWIWSVIQSSTGPCSKMVGTDPLCQAPYGCMNSLAQLDCGLPTHGCFHRASSCPILPFLCPTQPSSCQGRVLLGLKHDGAVPWSSWVKATEGTLEDHHVFRRTGQSQGSAVFWQAGGSGRGKAAPRMSSSSLLAEAPLEPPVLLSDIKTEPPEELLASDCSQPQAEPVDLSLNKSKAPPPPPPVQSSPLLVAPPVPASTISIASSGLGTTSAIPAVLSPGSILASSQGSGGQQILHVIHTIPSVNLPSKMGNLQTIPVVVQSLPVVYTTMPTDGVTAITVPLIGGDGKNTGSVKMDPGAMYPMDMPSDSEDSASESGPAPFQDLQRESATPRLPRSDSPDLKKRRIHQCDFEGCNKVYTKSSHLKAHRRIHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFRCSDCDRSFSRSDHLALHRRRHIMM", "length": 448 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M341-1", "protein_name": "KLF transcription factor 8", "gene_name": "Klf8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDKFINNMDVRIKTESDSMEVFKQVTGPVPTRDPSVRGDRRNMTSPPFLAASPMENPALFNDIKIEPPEELLESDFNTPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPPTAPQAIMVSTSADTVTSAAIPTVLTPGSILASSQGTGGQPILHVIHTIPSVSLPNKMSGLKTIPLVVQSLPMVYTSLPADGSPAAITVPLIGGDGKSAGSVKVDPASMCPLEFPSDSDESAIESGSSALQSLQGFHHEPATMVHMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM", "length": 355 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RTR0-1", "protein_name": "KLF transcription factor 8", "gene_name": "KLF8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGDMDQLINNLEVQLNSETGSMHVFKQVTGSVQIRDSLKTTGRGDMTSPPLLDINPMENPALLNDIKIEPPEELLANDFNLPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPEPVSQTLVESTSTSNTGTSANIPTVLTSGSILASSQGTGGQQILHVIHTIPSVSLPNKMSGLKAIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKVDPTSMSPLEIPSDSEENAIESGSSALQGIQGLQQEPAVMTQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCADCNRSFSRSDHLSLHRRRHDTM", "length": 359 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HWU8-1", "protein_name": "Krueppel-like factor 8", "gene_name": "Klf8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDRFINNLEAQLNSESDSMQVYKQVTGPVQTRNRSVTADRSNMTSPLLDASSMENPALFNDIKIEPPEELLASDFNLPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPPSAAQAIVVSTSSDTGTSATIPTVLTPGSILASSQGTGGQPILHVIHTIPSVGLPNKMGGLKTIPLVVQSLPMVYTSLPADGSPAAITVPLIGGDGKNAGSVKVDPTSMSPLEFPSDSDESAIESGSSALQGLHGLHQEPATMAQMQGEDSLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM", "length": 354 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95600-1", "protein_name": "Krueppel-like factor 8", "gene_name": "KLF8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVDMDKLINNLEVQLNSEGGSMQVFKQVTASVRNRDPPEIEYRSNMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGSQQILHVIHTIPSVSLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM", "length": 359 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BLM0-1", "protein_name": "Krueppel-like factor 8", "gene_name": "Klf8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDKFIDNMDVRIKSESGSMQVFKQVTGPVPTRDPSARADRRNMTSPSFLAASPMENPALFNDIKIEPPEELLESDFNMPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPPTAPQAIMVPTSADTVTSAAIPTVLTPGSILASSQGTGGQPILHVIHTIPSVSLPNKMSGLKTIPLVVQSLPMVYTSLPTDGSPAAITVPLIGGDGKSAGSVKVDPASMCPLEFPSDSDESAIESGSSALQSLQGFHHEPATMVHMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM", "length": 355 }, "evidence": [ { "id": "A0AAA9T3N2", "url": "https://omabrowser.org/oma/group/A0AAA9T3N2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 271, "end_pos": 300, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 337, "end_pos": 339 }, { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4M0-1", "uniprot_ac": "A0AAA9T4M0", "uniprot_id": "A0AAA9T4M0_BOVIN", "mass": { "chemical_mass": 107959.0, "monoisotopic_mass": 107959.0 }, "refseq": {}, "gene_names": [ { "name": "MYO19", "type": "recommended", "evidence": [ { "id": "A0AAA9T4M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ] } ], "protein_names": [ { "name": "Unconventional myosin-XIX", "type": "recommended", "evidence": [ { "id": "A0AAA9T4M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments. Required for mitochondrial inheritance during mitosis. May be involved in mitochondrial transport or positioning.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M5A8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5A8#function" }, { "database": "UniProtKB", "id": "ARBA00054433", "url": "https://www.uniprot.org/uniprotkb/ARBA00054433#function" }, { "database": "UniProtKB", "id": "F1MVD8", "url": "https://www.uniprot.org/uniprotkb/F1MVD8#function" }, { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0#function" }, { "database": "UniProtKB", "id": "G3MZU4", "url": "https://www.uniprot.org/uniprotkb/G3MZU4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYO19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0", "locus": { "chromosome": "19", "start_pos": 12848946, "end_pos": 12884004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012675", "url": "https://www.ensembl.org/id/ENSBTAG00000012675" } ] } } ], "crossref": [ { "id": "A0AAA9T4M0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4M0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012675", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012675", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14880", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14880", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508229", "url": "https://www.ncbi.nlm.nih.gov/gene/508229", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013419", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013419", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013425", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013425", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M5A8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5A8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVD8", "url": "https://www.uniprot.org/uniprotkb/F1MVD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVD8-1", "url": "https://www.uniprot.org/uniprotkb/F1MVD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZU4", "url": "https://www.uniprot.org/uniprotkb/G3MZU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZU4-1", "url": "https://www.uniprot.org/uniprotkb/G3MZU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQQVNGHGSGSAAHSGESLREDLKELLGGEVPPQQLNDLTKVNPVTLETVLRCLQARYMADTFYTNAGCTLVAMNPFKPVPQLYSPELMREYHAASQPQTLKPHIFTVGEQTYRNVKSLIEPVNQSVVVSGESGAGKTWTSRCLMKFYAVVAASPMSWESHKVAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNGAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIYKGAHAEERVRWRLPEGAAFSWLPHPERTLEEDCFEVTREAMLHLGIDAPTQNNIFQALAGLLHLGNTRFADSGNEAQPCPLVDDAQCSVGTSALLLGLPEDHLLETLQIRTIRAGRGQQVFQKPCSQAECNTRRDCLAKLVYARLFDWLVSVINSSICAAPDSWTTFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAMEGLAWSFVSYQDNQPCLDLIEGSPVSICSLINEECRLNRPSSAAQLQTRIESALTGHPRLGRDRLSPEPSFIVLHYAGPVRYRTAGLVEKNKDPVPPELTSLLQQSQDPLLKVLFPADPEDKSPEEPSGQNRAPVLTVVSKFKASLEQLLQVLHGTTPHYIRCIKPNSQAQAQIFHREEVLSQLEACGLVETIHISAAGFPIRVSHRNFMERYQLLRRLRPAITPSPHGPCPDGGRSECPPCTEPATLQGLLQEILHTLPAPLHCGRTKVFMTDSTLELLERGRAQVLEQCARHIQRGWRRHRCRTQARRRRAAVLIQAAVRSWLTRKHIQQLHAAATVIKRAWREWRIRMAFLASEELDGVEEKHSPHAPCSPGSSPLPPAQTRLQGAITRLWPLGLALANAAVGVHGFQRKLVVFACLQLPVGSPRSCAVQTAQEQAGVLSIRALPQAFSCQQPRQRHVINTRLPDNSHRDSECTQGAMAPACRRASGCTSGLGQQSTHPLPPHPDGYQGWQ", "length": 970, "header": "tr|A0AAA9T4M0-1|A0AAA9T4M0_BOVIN Isoform 1 of Unconventional myosin-XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=1 CANONICAL=A0AAA9T4M0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#A0A3Q1M5A8-1", "sequence": { "sequence": 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"tr|A0A3Q1M5A8-1|A0AAA9T4M0_BOVIN Computationally mapped isoform of Unconventional myosin-XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=1 CANONICAL=A0AAA9T4M0-1" }, "locus": { "chromosome": "19", "start_pos": 12881729, "end_pos": 12849156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069871.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069871.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063463.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063463.2" } ] } }, { "isoform_ac": "A0AAA9T4M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#A0AAA9T4M0-1", "sequence": { "sequence": "MLQQVNGHGSGSAAHSGESLREDLKELLGGEVPPQQLNDLTKVNPVTLETVLRCLQARYMADTFYTNAGCTLVAMNPFKPVPQLYSPELMREYHAASQPQTLKPHIFTVGEQTYRNVKSLIEPVNQSVVVSGESGAGKTWTSRCLMKFYAVVAASPMSWESHKVAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNGAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIYKGAHAEERVRWRLPEGAAFSWLPHPERTLEEDCFEVTREAMLHLGIDAPTQNNIFQALAGLLHLGNTRFADSGNEAQPCPLVDDAQCSVGTSALLLGLPEDHLLETLQIRTIRAGRGQQVFQKPCSQAECNTRRDCLAKLVYARLFDWLVSVINSSICAAPDSWTTFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAMEGLAWSFVSYQDNQPCLDLIEGSPVSICSLINEECRLNRPSSAAQLQTRIESALTGHPRLGRDRLSPEPSFIVLHYAGPVRYRTAGLVEKNKDPVPPELTSLLQQSQDPLLKVLFPADPEDKSPEEPSGQNRAPVLTVVSKFKASLEQLLQVLHGTTPHYIRCIKPNSQAQAQIFHREEVLSQLEACGLVETIHISAAGFPIRVSHRNFMERYQLLRRLRPAITPSPHGPCPDGGRSECPPCTEPATLQGLLQEILHTLPAPLHCGRTKVFMTDSTLELLERGRAQVLEQCARHIQRGWRRHRCRTQARRRRAAVLIQAAVRSWLTRKHIQQLHAAATVIKRAWREWRIRMAFLASEELDGVEEKHSPHAPCSPGSSPLPPAQTRLQGAITRLWPLGLALANAAVGVHGFQRKLVVFACLQLPVGSPRSCAVQTAQEQAGVLSIRALPQAFSCQQPRQRHVINTRLPDNSHRDSECTQGAMAPACRRASGCTSGLGQQSTHPLPPHPDGYQGWQ", "length": 970, "header": "tr|A0AAA9T4M0-1|A0AAA9T4M0_BOVIN Isoform 1 of Unconventional myosin-XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=1 CANONICAL=A0AAA9T4M0-1" }, "locus": { "chromosome": "19", "start_pos": 12881729, "end_pos": 12850902, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124661.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124661.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092749.1" } ] } }, { "isoform_ac": "A0AAA9TT99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#A0AAA9TT99-1", "sequence": { "sequence": "MLQQTWTSRCLMKFYAVVAASPMSWESHKVAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNGAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIYKGAHAEERVRWRLPEGAAFSWLPHPERTLEEDCFEVTREAMLHLGIDAPTQNNIFQVRGKATPLTCGGGDGQPPS", "length": 183, "header": "tr|A0AAA9TT99-1|A0AAA9TT99_BOVIN Computationally mapped isoform of Myosin XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=1 CANONICAL=A0AAA9T4M0-1" }, "locus": { "chromosome": "19", "start_pos": 12881729, "end_pos": 12866131, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132907.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132907.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101582.1" } ] } }, { "isoform_ac": "F1MVD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#F1MVD8-1", "sequence": { "sequence": "MLQQVNGHGSGSAAHSGESLREDLKELLGGEVPPQQLNDLTKVNPVTLETVLRCLQARYMADTFYTNAGCTLVAMNPFKPVPQLYSPELMREYHAASQPQTLKPHIFTVGEQTYRNVKSLIEPVNQSVVVSGESGAGKTWTSRCLMKFYAVVAASPMSWESHKVAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNGAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIYKGAHAEERVRWRLPEGAAFSWLPHPERTLEEDCFEVTREAMLHLGIDAPTQNNIFQALAGLLHLGNTRFADSGNEAQPCPLVDDAQCSVGTSALLLGLPEDHLLETLQIRTIRAGRGQQVFQKPCSQAECNTRRDCLAKLVYARLFDWLVSVINSSICAAPDSWTTFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQTPTALHPQEEYAMEGLAWSFVSYQDNQPCLDLIEGSPVSICSLINEECRLNRPSSAAQLQTRIESALTGHPRLGRDRLSPEPSFIVLHYAGPVRYRTAGLVEKNKDPVPPELTSLLQQSQDPLLKVLFPADPEDKSPEEPSGQNRAPVLTVVSKFKASLEQLLQVLHGTTPHYIRCIKPNSQAQAQIFHREEGSMARITALW", "length": 653, "header": "tr|F1MVD8-1|F1MVD8_BOVIN Computationally mapped isoform of Unconventional myosin-XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=3 CANONICAL=A0AAA9T4M0-1" }, "locus": { "chromosome": "19", "start_pos": 12881729, "end_pos": 12858692, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016840.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016840.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016840.6", "url": "https://www.ensembl.org/id/ENSBTAP00000016840.6" } ] } }, { "isoform_ac": "G3MZU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0/entry#G3MZU4-1", "sequence": { "sequence": "MLQQVNGHGSGSAAHSGESLREDLKELLGGEVPPQQLNDLTKVNPVTLETVLRCLQARYMADTFYTNAGCTLVAMNPFKPVPQLYSPELMREYHAASQPQTLKPHIFTVGEQTYRNVKSLIEPVNQSVVVSGESGAGKTWTSRCLMKFYAVVAASPMSWESHKVAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFIQLQLNGAQQMTGAAVQTYLLEKTRVACQAPSERNFHIFYQIYKGAHAEERVRWRLPEGAAFSWLPHPERTLEGLWLGFLYRGLFRGDQGGHASFGHRCPHPEQHLSGSVGTSALLLGLPEDHLLETLQIRTIRAGRGQQVFQKPCSQAECNTRRDCLAKLVYARLFDWLVSVINSSICAAPDSWTTFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAMEGLAWSFVSYQDNQPCLDLIEGSPVSICSLINEECRLNRPSSAAQLQTRIESALTGHPRLGRDRLSPEPSFIVLHYAGPVRYRTAGLVEKNKDPVPPELTSLLQQSQDPLLKVLFPADPEDKSPEEPSGQNRAPVLTVVSKFKASLEQLLQVLHGTTPHYIRCIKPNSQAQAQIFHREEVLSQLEACGLVETIHISAAGFPIRVSHRNFMERYQLLRRLRPAITPSPHGPCPDGGRSECPPCTEPATLQGLLQEILHTLPAPLHCGRTKVFMTDSTLELLERGRAQVLEQCARHIQRGWRRHRCRTQARRRRAAVLIQAAVRSWLTRKHIQQLHAAATVIKRAWREWRIRMAFLASEELDGVEEKHSPHAPCSPGSSPLPPAQTRLQGAITRLWPLGLALANAAVGVHGFQRKLVVFACLQLPVGSPRSCAVQTAQEQAGVLSIRALPQGSIRFHCRKSPLRYADTCPGPSPDSVTGFNQILLERHRPGHV", "length": 925, "header": "tr|G3MZU4-1|G3MZU4_BOVIN Computationally mapped isoform of Unconventional myosin-XIX OS=Bos taurus OX=9913 GN=MYO19 PE=3 SV=2 CANONICAL=A0AAA9T4M0-1" }, "locus": { "chromosome": "19", "start_pos": 12881729, "end_pos": 12851160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064679.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064679.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055097.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055097.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 680, "start_aa": "Thr", "end_pos": 680, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr680", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9013419", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013419", "resource": "Reactome", "description": "RHOT2 GTPase cycle" }, { "id": "R-BTA-9013425", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013425", "resource": "Reactome", "description": "RHOT1 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "myosin light chain binding", "id": "GO:0032027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032027", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "plus-end directed microfilament motor activity", "id": "GO:0060002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060002", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M0" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": 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"uniprotkb_annotation": "Myosin motor", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 741, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 680 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 192, "end_pos": 194 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 423, "end_pos": 425 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T420-1", "uniprot_ac": "A0AAA9T420", "uniprot_id": "A0AAA9T420_BOVIN", "mass": { "chemical_mass": 93507.0, "monoisotopic_mass": 93507.0 }, "refseq": {}, "gene_names": [ { "name": "SHLD2", "type": "recommended", "evidence": [ { "id": "A0AAA9T420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ] } ], "protein_names": [ { "name": "Shieldin complex subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHLD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420", "locus": { "chromosome": "28", "start_pos": 41771062, "end_pos": 41649210, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019194", "url": "https://www.ensembl.org/id/ENSBTAG00000019194" } ] } } ], "crossref": [ { "id": "A0AAA9T420", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T420", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019194", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019194", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508335", "url": "https://www.ncbi.nlm.nih.gov/gene/508335", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508335", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508335", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M7H1", "url": "https://www.orthodb.org/?gene=A0A3Q1M7H1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBC8", "url": "https://www.orthodb.org/?gene=E1BBC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14495", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14495", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14495:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14495:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M7H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7H1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5D7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMW0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T420-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC8", "url": "https://www.uniprot.org/uniprotkb/E1BBC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBC8-1", "url": "https://www.uniprot.org/uniprotkb/E1BBC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 837, "header": "tr|A0AAA9T420-1|A0AAA9T420_BOVIN Isoform 1 of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=2 CANONICAL=A0AAA9T420-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M7H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#A0A3Q1M7H1-1", "sequence": { "sequence": "MLCNKRSHRSEKPAHHNYRKACAETRTAQPKNKQIKLFLKNTEAVIDCAYRLKIETMSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNCILENLELHTTPWSSCECLFDDDRRAITFKAKFQKNTPSFVKMSDLATHLEEKRSGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 926, "header": "tr|A0A3Q1M7H1-1|A0AAA9T420_BOVIN Computationally mapped isoform of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=2 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41763325, "end_pos": 41726600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071993.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071993.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069761.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069761.2" } ] } }, { "isoform_ac": "A0AAA9S5D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#A0AAA9S5D7-1", "sequence": { "sequence": "MEVIGDLEICCSVECFGPMLDRSGFKRKWETMSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNCILENLELHTTPWSSCECLFDDDRRAITFKAKFQKNTPSFVKMSDLATHLEEKRSGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 937, "header": "tr|A0AAA9S5D7-1|A0AAA9T420_BOVIN Computationally mapped isoform of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=1 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41763325, "end_pos": 41724567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133336.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133336.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077374.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077374.1" } ] } }, { "isoform_ac": "A0AAA9SJX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#A0AAA9SJX0-1", "sequence": { "sequence": "MLCNKRSHRSEKPAHHNYRKACAETRTAQPKNKQIKLFLKNTEAVIDCAYRLKIETMSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNCILENLELHTTPWSSCECLFDDDRRAITFKAKFQKNTPSFVKMSDLATHLEEKRSGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 962, "header": "tr|A0AAA9SJX0-1|A0AAA9T420_BOVIN Computationally mapped isoform of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=1 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41763325, "end_pos": 41726600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117725.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117725.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086601.1" } ] } }, { "isoform_ac": "A0AAA9SMW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#A0AAA9SMW0-1", "sequence": { "sequence": "MSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNCILENLELHTTPWSSCECLFDDDRRAITFKAKFQKNTPSFVKMSDLATHLEEKRSGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 906, "header": "tr|A0AAA9SMW0-1|A0AAA9T420_BOVIN Computationally mapped isoform of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=2 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41763325, "end_pos": 41727603, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093502.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093502.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085311.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085311.2" } ] } }, { "isoform_ac": "A0AAA9T420-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#A0AAA9T420-1", "sequence": { "sequence": "MSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIAPPSDVTYGMAAADLLHALLAGSGAPCVLKVQSLFVLDENSYPLQQDFSLLDFYLNDLKHASHALL", "length": 837, "header": "tr|A0AAA9T420-1|A0AAA9T420_BOVIN Isoform 1 of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=2 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41763325, "end_pos": 41727603, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134495.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134495.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093548.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093548.2" } ] } }, { "isoform_ac": "E1BBC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420/entry#E1BBC8-1", "sequence": { "sequence": "MARLGSEELGFKPRYSRLQFGNNCCCCCCCKVASVVSDSVQPHRRQPTRLSRPWDSQDKNTGVGCHFLLQCMKVKSESEVVSDSYRPHGLQPTRLLHPWDFPETMSGGSQVHIFWGAPVSPLEMTVSQEPTSVASTAETWKEIQVLYNHHSLYLKDEKCRHKNLEDCQALEPLGLPDLPHGHFPANSMNRSVHMKDDTTHRISEAQTVKSQKAYPLGMSDRTSSSEQVRGFKGGVQHFTEEEKYQKLSSELKKTRNEQHDQSNMCGQNIPKNPFHLAHKCAAILDAVCGAEQTNTPEAIKINSAPAEHHEIQNQCLEFFLANTGDKPRPEGTVGKASGVKISTDTEFLSIMTSSQVAFLAQRKYKGQKSINKGTINMEIEPEANYGEIRITEDNLIQSKDDSAGGNEDGQNQACSLELFSPVCPETKSSHTLLNTDKDLEENIGSQGLFNCDDKFQPNEILIESCNSGILCSQLNTFCKSSGKRSWTSEDKSGHPQALSEVPHVAKKIKLFSNERDHTVTVDRRNMFGFKGIKKTSLIKNCDSEHQKYNCLVMVLSPCHMKEINIKSGPNSGSKVPLATIVVTDQSEIKKKVFLWRTAAFWALTVFLGDIILLTDVTIHEDHWVGETVLQSTFTSQLLNLGSYSSVQPEEYSSMISNVVLQDLLAYVSSKHSYLRDLPQRHPQKMSSIEFIELEQLQPDILVHAILRVVDITVLTEALYSYRGQKQRKVMLTVEQTQGQHYVLVLWGPGAAWYPQLQRKKGYIWEFKYLFVQRNCILENLELHTTPWSSCECLFDDDRRAITFKAKFQKNTPSFVKMSDLATHLEEKRSGVILMKAQILELVFPIAAVQKIALNARSSLKSIFCSLPNIIYTGCAKCGLELQTDENKIYKQCFSCLPFTMKKIYYRPALMTIVDGKYKVCIHVGSKLIEKILLNISPDWLNRVIGHICREGLQSRGRTKGGRRCKLESILAEMCPHTRAKYGDDWPEKKKSPENCHYISNLSCP", "length": 1004, "header": "tr|E1BBC8-1|E1BBC8_BOVIN Computationally mapped isoform of Shieldin complex subunit 2 OS=Bos taurus OX=9913 GN=SHLD2 PE=4 SV=3 CANONICAL=A0AAA9T420-1" }, "locus": { "chromosome": "28", "start_pos": 41770780, "end_pos": 41687256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025542.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025542.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025542.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025542.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508335", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508335", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via nonhomologous end joining", "id": "GO:2001034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001034", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" }, { "name": "positive regulation of isotype switching", "id": "GO:0045830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045830", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" }, { "name": "regulation of double-strand break repair via homologous recombination", "id": "GO:0010569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010569", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T420", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" }, { "id": "PF15793", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15793" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shieldin complex subunit 2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 662, "end_pos": 825, "start_aa": "Lys", "end_aa": "Tyr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" }, { "id": "PF21669", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21669" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shieldin complex subunit 2 first OB fold", "eco_id": "ECO_0000259", "start_pos": 426, "end_pos": 561, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T420" }, { "id": "PF22779", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22779" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Shieldin complex subunit 2 second OB fold", "eco_id": "ECO_0000259", "start_pos": 593, "end_pos": 659, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 761, "end_pos": 763 }, { "start_pos": 85, "end_pos": 87 } ] }, 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"glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T161-1", "uniprot_ac": "A0AAA9T161", "uniprot_id": "A0AAA9T161_BOVIN", "mass": { "chemical_mass": 36042.0, "monoisotopic_mass": 36042.0 }, "refseq": {}, "gene_names": [ { "name": "GOLGA7B", "type": "recommended", "evidence": [ { "id": "A0AAA9T161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161" } ] } ], "protein_names": [ { "name": "Golgin A7 family member B", "type": "synonym", "evidence": [ { "id": "A0AAA9T161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T161", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLGA7B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161", "locus": { "chromosome": "26", "start_pos": 19008049, "end_pos": 18970478, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008100", "url": "https://www.ensembl.org/id/ENSBTAG00000008100" } ] } } ], "crossref": [ { "id": "A0AAA9T161", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T161", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008100", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767832", "url": "https://www.ncbi.nlm.nih.gov/gene/767832", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEI3", "url": "https://www.orthodb.org/?gene=A0A3Q1MEI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13254:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13254:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MEI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T161", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T161-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TII4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TII4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TII4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TII4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RR32", "url": "https://www.uniprot.org/uniprotkb/F6RR32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RR32-1", "url": "https://www.uniprot.org/uniprotkb/F6RR32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNERVKGPSMGMCARVCVCERERPREKRIWVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSASLPTPPEKDPSPSNRECPSCMVLDSKSHIHQDSLPRGPTPRGCLPVCMLSDATTGPLPVCDPASTDSRSGETGVVSPLLTSSRLLASLSSTQSLEVILDSLRSVQLLRLGRPGAGGGGAHGLASGRLYGGPERCFMERCSLGGLEPPKREPTS", "length": 328, "header": "tr|A0AAA9T161-1|A0AAA9T161_BOVIN Isoform 1 of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#A0A3Q1MEI3-1", "sequence": { "sequence": "MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSASLPTPPEKDPSPSNRECPSCMDLPSLRLSAASLPPRQWGVRSTPQDHGEGM", "length": 200, "header": "tr|A0A3Q1MEI3-1|A0AAA9T161_BOVIN Computationally mapped isoform of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=2 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19006626, "end_pos": 18993661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086524.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086524.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068905.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068905.2" } ] } }, { "isoform_ac": "A0AAA9SDZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#A0AAA9SDZ6-1", "sequence": { "sequence": "MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKAGSLPLVPPGKPAFNQWLISIHARCHMDPDSEPPSQRPPEPRSELRPTLHCPCI", "length": 166, "header": "tr|A0AAA9SDZ6-1|A0AAA9T161_BOVIN Computationally mapped isoform of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19003833, "end_pos": 18993661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124435.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124435.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081813.1" } ] } }, { "isoform_ac": "A0AAA9T161-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#A0AAA9T161-1", "sequence": { "sequence": "MNERVKGPSMGMCARVCVCERERPREKRIWVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSASLPTPPEKDPSPSNRECPSCMVLDSKSHIHQDSLPRGPTPRGCLPVCMLSDATTGPLPVCDPASTDSRSGETGVVSPLLTSSRLLASLSSTQSLEVILDSLRSVQLLRLGRPGAGGGGAHGLASGRLYGGPERCFMERCSLGGLEPPKREPTS", "length": 328, "header": "tr|A0AAA9T161-1|A0AAA9T161_BOVIN Isoform 1 of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19005450, "end_pos": 19000786, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092369.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092369.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090300.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090300.1" } ] } }, { "isoform_ac": "A0AAA9TII4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#A0AAA9TII4-1", "sequence": { "sequence": "MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSASLPTPPEKDPSPSNRECPSCMVLDSKSHIHQDSLPRGPTPRGCLPVCMLSDATTGPLPVCDPASTDSRSGETGVVSPLLTSSRLLASLSSTQSLEVILDSLRSVQLLRLGRPGAGGGGAHGLASGRLYGGPERCFMERCSLGGLEPPKREPTS", "length": 302, "header": "tr|A0AAA9TII4-1|A0AAA9TII4_BOVIN Computationally mapped isoform of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19005450, "end_pos": 18993661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096032.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096032.1" } ] } }, { "isoform_ac": "A0AAA9TTE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#A0AAA9TTE2-1", "sequence": { "sequence": "MATEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSASLPTPPEKDPSPSNRECPSCMIKRLRLTEVK", "length": 180, "header": "tr|A0AAA9TTE2-1|A0AAA9TTE2_BOVIN Computationally mapped isoform of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19007898, "end_pos": 18993661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121868.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121868.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101901.1" } ] } }, { "isoform_ac": "F6RR32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161/entry#F6RR32-1", "sequence": { "sequence": "MEVHNLQELRRSASLATKVFIQRDYSDGTICQFQTKFPPELDSRIERQLFEETVKTLNSFYAEAEKIGGSSYLEGCLACATAYFIFLCMETHYEKVLKKISRYIQEQNEKVFAPRGLLLTDPVERGMRVIEISIYEDRCSSGSSSSGSSSGSGSSSGGGGGAGGR", "length": 165, "header": "tr|F6RR32-1|F6RR32_BOVIN Computationally mapped isoform of Golgin A7 family member B OS=Bos taurus OX=9913 GN=GOLGA7B PE=3 SV=1 CANONICAL=A0AAA9T161-1" }, "locus": { "chromosome": "26", "start_pos": 19004670, "end_pos": 18970498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010654.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010654.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010654.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010654.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 179, "start_aa": "Thr", "end_pos": 179, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 214, "start_aa": "Thr", "end_pos": 214, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr214", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T161", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T161" }, { "id": "PF10256", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10256" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Golgin subfamily A member 7/ERF4", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 159, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 179, 214 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2F6-1", "uniprot_ac": "A0AAA9T2F6", "uniprot_id": "A0AAA9T2F6_BOVIN", "mass": { "chemical_mass": 43949.0, "monoisotopic_mass": 43949.0 }, "refseq": {}, "gene_names": [ { "name": "MEST", "type": "recommended", "evidence": [ { "id": "A0AAA9T2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ] } ], "protein_names": [ { "name": "Mesoderm specific transcript", "type": "synonym", "evidence": [ { "id": "A0AAA9T2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6#function" }, { "database": "UniProtKB", "id": "ARBA00094336", "url": "https://www.uniprot.org/uniprotkb/ARBA00094336#function" }, { "database": "UniProtKB", "id": "F1MZU5", "url": "https://www.uniprot.org/uniprotkb/F1MZU5#function" }, { "database": "UniProtKB", "id": "A0A3Q1MPI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI9#function" }, { "database": "UniProtKB", "id": "A0AAA9SL35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL35#function" }, { "database": "UniProtKB", "id": "A0AAA9TTD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD2#function" }, { "database": "UniProtKB", "id": "A0AAA9U172", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U172#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEST", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6", "locus": { "chromosome": "4", "start_pos": 94263779, "end_pos": 94216025, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017223", "url": "https://www.ensembl.org/id/ENSBTAG00000017223" } ] } } ], "crossref": [ { "id": "A0AAA9T2F6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017223", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017223", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000639", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000639", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CDMLGFG", "url": "https://omabrowser.org/oma/group/CDMLGFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPI9", "url": "https://www.orthodb.org/?gene=A0A3Q1MPI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MZU5", "url": "https://www.orthodb.org/?gene=F1MZU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43798", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43798", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43798:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43798:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MPI9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPI9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U172", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U172", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U172-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U172-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZU5", "url": "https://www.uniprot.org/uniprotkb/F1MZU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MZU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPEQGNCLLQIEGSKMNSRYFGGKLKRRGKEEGGSRELARICTQGCLPFSPIPSGDRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 384, "header": "tr|A0AAA9T2F6-1|A0AAA9T2F6_BOVIN Isoform 1 of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=1 CANONICAL=A0AAA9T2F6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MPI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#A0A3Q1MPI9-1", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 301, "header": "tr|A0A3Q1MPI9-1|A0AAA9T2F6_BOVIN Computationally mapped isoform of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=3 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94262621, "end_pos": 94251074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066894.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066894.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073380.3", "url": "https://www.ensembl.org/id/ENSBTAP00000073380.3" } ] } }, { "isoform_ac": "A0AAA9SL35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#A0AAA9SL35-1", "sequence": { "sequence": "MVGPLWAPRVGICGAEFSGERNSAIMVVLVSGALLKLLQKYRERDSRWLQGLRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 379, "header": "tr|A0AAA9SL35-1|A0AAA9T2F6_BOVIN Computationally mapped isoform of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=1 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94262621, "end_pos": 94216224, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084593.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084593.1" } ] } }, { "isoform_ac": "A0AAA9T2F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#A0AAA9T2F6-1", "sequence": { "sequence": "MKPEQGNCLLQIEGSKMNSRYFGGKLKRRGKEEGGSRELARICTQGCLPFSPIPSGDRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 384, "header": "tr|A0AAA9T2F6-1|A0AAA9T2F6_BOVIN Isoform 1 of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=1 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94262621, "end_pos": 94244470, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105550.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105550.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092975.1" } ] } }, { "isoform_ac": "A0AAA9TTD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#A0AAA9TTD2-1", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYSLFSLSWLSVYMCHSTCSTVYR", "length": 318, "header": "tr|A0AAA9TTD2-1|A0AAA9TTD2_BOVIN Computationally mapped isoform of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=2 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94261857, "end_pos": 94251074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135844.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135844.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099792.2" } ] } }, { "isoform_ac": "A0AAA9U172-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#A0AAA9U172-1", "sequence": { "sequence": "MDGGAWMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 332, "header": "tr|A0AAA9U172-1|A0AAA9U172_BOVIN Computationally mapped isoform of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=1 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94262621, "end_pos": 94244951, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127569.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127569.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103782.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103782.1" } ] } }, { "isoform_ac": "F1MZU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6/entry#F1MZU5-1", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQSRRINLLSHDYGDTVAQELLYRFKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGMLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 335, "header": "tr|F1MZU5-1|A0AAA9T2F6_BOVIN Computationally mapped isoform of Mesoderm specific transcript OS=Bos taurus OX=9913 GN=MEST PE=3 SV=1 CANONICAL=A0AAA9T2F6-1" }, "locus": { "chromosome": "4", "start_pos": 94262621, "end_pos": 94251074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044831.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044831.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042286.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042286.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XVV5-1", "protein_name": "Mesoderm specific transcript", "gene_name": "MEST", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERLVKGAWLVRGRAGLSGEGVGLSGGVRMKEWWVQVGLLSVPLLAVYLHIPPPRLSPALLSWKASGAFFTYKHQSIFYRDSTGAVGSSDVVILLHGFPTSSYDWSKIWEGLTQRFHRVIALDFVGFGFSDKPRPHHYSIFEQASIVERLVRHLGLHHQRINLLSHDYGDTVAQELLHRYEHNKTGSILINSLCLSNGGIFPETYYPRFIQKVLKDGGLLSPIITRLMNFFFFSRGLGAVFGPYTQPSQAEYWDMWTAVRTNDGNLVVDSILQYINQRKKHRDRWVGALMSTSVPLHLIYGPLDPVNPHPEFLQLYKKVLPMSTVSVLDDHISHYPQLEDPTGFLNAYLNFINSF", "length": 355 }, "evidence": [ { "id": "A0AAA9T2F6", "url": "https://omabrowser.org/oma/group/A0AAA9T2F6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q07646-1", "protein_name": "Mesoderm-specific transcript protein", "gene_name": "Mest", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVESLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAVIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVSIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 335 }, "evidence": [ { "id": "A0AAA9T2F6", "url": "https://omabrowser.org/oma/group/A0AAA9T2F6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q1L8N7-1", "protein_name": "Mesoderm-specific transcript homolog protein isoform 1", "gene_name": "mest", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGDSPQNDSECGSARRVSREWWLHVGLLCVPLLAVYLHIPPPQLSPALNSWRTSGHFFTFRGNDIFYKESVGVVGSSDVLVLLHGFPTSSYDWYKIWDSLTQRFNRVIALDFLGFGFSDKPRPHRYSIFEQASVVEALVAHLGLSEQRINILSHDYGDTVALELLYRSDHNRSGHIIVNSLCLSNGGIFPETHHPRFLQKVLKDSGFISPVLTRLMNFQLFSRGIKEVFGPYTQPTEAEVWDMWTGIRFNDGNLVMDSLLQYINQRLKHRERWVGALTSTLTPLHMIYGPLDPVNPHPQFLQLYQKLVQRSTVSVLDEHVSHYPQLEDPTGFFNAYLSFINSF", "length": 344 }, "evidence": [ { "id": "A0AAA9T2F6", "url": "https://omabrowser.org/oma/group/A0AAA9T2F6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5EB52-1", "protein_name": "Mesoderm-specific transcript homolog protein", "gene_name": "MEST", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 335 }, "evidence": [ { "id": "A0AAA9T2F6", "url": "https://omabrowser.org/oma/group/A0AAA9T2F6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P5P5-1", "protein_name": "Mesoderm-specific transcript homolog protein", "gene_name": "Mest", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVESLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF", "length": 335 }, "evidence": [ { "id": "A0AAA9T2F6", "url": "https://omabrowser.org/oma/group/A0AAA9T2F6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "response to retinoic acid", "id": "GO:0032526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "negative regulation of protein localization to plasma membrane", "id": "GO:1903077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "regulation of lipid storage", "id": "GO:0010883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010883", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "radial glia-guided pyramidal neuron migration", "id": "GO:0140650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" }, { "name": "negative regulation of glycoprotein biosynthetic process", "id": "GO:0010561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010561", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F6" }, { "id": "PF00561", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00561" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AB hydrolase-1", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 370, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4I2-1", "uniprot_ac": "A0AAA9T4I2", "uniprot_id": "A0AAA9T4I2_BOVIN", "mass": { "chemical_mass": 82597.0, "monoisotopic_mass": 82597.0 }, "refseq": { "ac": "XP_002695131", "name": "zinc finger protein 235 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695131" }, "gene_names": [ { "name": "ZNF235", "type": "recommended", "evidence": [ { "id": "A0AAA9T4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ] }, { "name": "ZNF235", "type": "synonym", "evidence": [ { "id": "XP_002695131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695131" } ] } ], "protein_names": [ { "name": "Zinc finger protein 235", "type": "recommended", "evidence": [ { "id": "A0AAA9T4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 235 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_002695131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695131" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RXM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM4#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2#function" }, { "database": "UniProtKB", "id": "A0AAA9TJ99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ99#function" }, { "database": "UniProtKB", "id": "F1MLE7", "url": "https://www.uniprot.org/uniprotkb/F1MLE7#function" }, { "database": "UniProtKB", "id": "A0AAA9TQN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQN7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF235", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2", "locus": { "chromosome": "18", "start_pos": 52210529, "end_pos": 52234085, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007714", "url": "https://www.ensembl.org/id/ENSBTAG00000007714" } ] } } ], "crossref": [ { "id": "A0AAA9T4I2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4I2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007714", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007714", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051250", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051250", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504436", "url": "https://www.ncbi.nlm.nih.gov/gene/504436", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504436", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504436", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MLE7", "url": "https://www.orthodb.org/?gene=F1MLE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23232:SF156", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23232:SF156", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF132", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF132", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF114", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF114", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002695131", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695131", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MU21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE7", "url": "https://www.uniprot.org/uniprotkb/F1MLE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 733, "header": "tr|A0AAA9T4I2-1|A0AAA9T4I2_BOVIN Isoform 1 of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=1 CANONICAL=A0AAA9T4I2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MU21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#A0A3Q1MU21-1", "sequence": { "sequence": "MTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGFHCCIFS", "length": 86, "header": "tr|A0A3Q1MU21-1|A0AAA9T4I2_BOVIN Computationally mapped isoform of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=3 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52225570, "end_pos": 52182246, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073000.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073000.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073999.3", "url": "https://www.ensembl.org/id/ENSBTAP00000073999.3" } ] } }, { "isoform_ac": "A0AAA9RXM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#A0AAA9RXM4-1", "sequence": { "sequence": "MTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 702, "header": "tr|A0AAA9RXM4-1|A0AAA9T4I2_BOVIN Computationally mapped isoform of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=1 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52225570, "end_pos": 52211533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077293.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077293.1" } ] } }, { "isoform_ac": "A0AAA9T4I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#A0AAA9T4I2-1", "sequence": { "sequence": "MTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 733, "header": "tr|A0AAA9T4I2-1|A0AAA9T4I2_BOVIN Isoform 1 of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=1 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52225570, "end_pos": 52211533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088145.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088145.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093684.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093684.1" } ] } }, { "isoform_ac": "A0AAA9TJ99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#A0AAA9TJ99-1", "sequence": { "sequence": "MTEDEMVGWHHQLDGHEFQQALRVGDRQGSLACFSPWSCKQSDSTELEGVTDPSAPGPGPHFYLPRTRPFPRRKREKKMTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 811, "header": "tr|A0AAA9TJ99-1|A0AAA9TJ99_BOVIN Computationally mapped isoform of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=1 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52232079, "end_pos": 52211533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091582.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091582.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096998.1" } ] } }, { "isoform_ac": "A0AAA9TQN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#A0AAA9TQN7-1", "sequence": { "sequence": "MTKLQEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 705, "header": "tr|A0AAA9TQN7-1|A0AAA9TQN7_BOVIN Computationally mapped isoform of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=1 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52225570, "end_pos": 52211533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113205.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113205.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100898.1" } ] } }, { "isoform_ac": "F1MLE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2/entry#F1MLE7-1", "sequence": { "sequence": "MWDLFPHQGSNWSPLHCKEALTFKDVAVTFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQSSKPDMISELEREEFWMTEIQPQRGGCSGGGNHEMATVQDTGVRCLSRVELSCWQIRRHVVSKSTKSQDSVINTQKKSSQSPKQHNSPAGVSAQASMEGSCFVTLIEDHSDIIENQAFPAGRALNSWSKLCLSETQNYQRGCQLTSMKNKICMFAPCVDFFPRISPHHDDHTVPQREKAQGTRECGKDLLKASPLAQRSIVEAGPKAYPSNEGERGLGDRTSLELHQRLHLGGKSPTHRTPKKDPAHGSARPTPPGALPGTKRYWCRECGKGFSQSSNLQTHQRVHTGEKPYSCHECGKSFNQTSHLYAHLPIHTGEKPYRCESCGKGFSRSTDLNIHCRVHTGEKPYKCEACGKGFTQRSHLQAHERIHTGEKPYRCADCGKRFSCSSNLHTHQRVHTEEKPYKCEECGKRFSLSFNLHSHRRVHTGEKPYKCQECGKGFSSASSFQSHQRVHTGEKPFRCSECGKGFSQSSYFQAHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQSVHTGEKPFKCAACQKRFSQASHLQAHQRVHTGEKPFKCGTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGEKPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDICCKGFSQRSHLVYHQRVHAGGNL", "length": 746, "header": "tr|F1MLE7-1|A0AAA9T4I2_BOVIN Computationally mapped isoform of Zinc finger protein 235 OS=Bos taurus OX=9913 GN=ZNF235 PE=3 SV=3 CANONICAL=A0AAA9T4I2-1" }, "locus": { "chromosome": "18", "start_pos": 52225260, "end_pos": 52211533, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010143.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010143.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010143.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010143.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 303, "start_aa": "Thr", "end_pos": 303, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr303", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504436", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504436", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 314, "end_pos": 341, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 78, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 303 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 }, { "start_pos": 548, "end_pos": 550 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2L7-1", "uniprot_ac": "A0AAA9T2L7", "uniprot_id": "A0AAA9T2L7_BOVIN", "mass": { "chemical_mass": 109969.0, "monoisotopic_mass": 109969.0 }, "refseq": {}, "gene_names": [ { "name": "DDX11", "type": "recommended", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ], "protein_names": [ { "name": "ATP-dependent DNA helicase DDX11", "type": "recommended", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#names_and_taxonomy" } ] }, { "name": "5.6.2.3", "type": "synonym", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#names_and_taxonomy" } ] }, { "name": "DEAD/H-box protein 11", "type": "synonym", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#names_and_taxonomy" } ] }, { "name": "DNA 5'-3' helicase DDX11", "type": "synonym", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7", "locus": { "chromosome": "5", "start_pos": 106998807, "end_pos": 106967130, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007093", "url": "https://www.ensembl.org/id/ENSBTAG00000007093" } ] } } ], "crossref": [ { "id": "A0AAA9T2L7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007093", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007093", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000050785", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050785", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18788", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18788", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014013", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014013", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11472", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11472", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11472:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11472:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06733", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06733", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N5S6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5S6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5S6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL06", "url": "https://www.uniprot.org/uniprotkb/E1BL06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BL06-1", "url": "https://www.uniprot.org/uniprotkb/E1BL06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METEPGTSLPRKRSGATRGPAPPSPGVRMRNAGWVGERAARRAALEDADTGEEPEFQVQRRPPGLLAGLASAEQPSRRGRIMADETQEAGGIHFPFPFTPYAIQKDFMAALYQVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKRQEEERLLGAGAPASHNGLAPALGLPSSCQGSPGTPGATGEPDWITQFVQKKEERDLVDRLKEEQVRRKKREERLQQIRHNAKLRFAAKRMRQEDEETERLLRLSSEMLATGTEPEQVASGEEELVLAEYESDEEKGVPSGVDMDEDDLDEEHVTKIYYCSRTHSQLAQFVHEVQKSPFGQDTRLVSLGSRQNLCVNGDVRKLGSVQLINDRCVEMQRSKHERKSITEEEEPTRRRRRQEPRATCPFYSYERLQLLRDEVLVGVKDVEQLVALGEEAQACPYYGGRFAIPAAQLVVLPYQMLLHAPTRQAAGIRLQGQVVVIDEAHNLIDTITNIHSVEVRGSQLCQAHSQLLQYTERYGKRLKAKNLMYIKQLLYLLEKFVAVLGGNIKQNPNTQSLSQAGTELKTINDFLFQSKIDNINLFKVRRYCEKSKISRKLLGFTERYGAVLVPSMEQPKLSGFQDFLQSLQPGAMAAPAAPVEVGEDRSPRPASPLMHVEGFLEALTTANQDGRVILSRQGSLSQSSLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFREQLLAGAGVEAERVVEFSCGHVIPPDHILPLIICSGPSNQMLDFTYQKRGLPQMMDETGRILCNLCNVVPGGVVCFFPSYEYQHQVCTHWEKSGLLARLTIRKKIFQEPRKANRVEQVLLEYSRCIKHCGQAQGTETGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIMSPELQEKMAYLDQTLPRGPGQARPGKVLVENLCMKAVNQSIGRAIRHQKDFASIVLLDQRYASPAIQAKLPAWIRDRVEVKATFGPAFAALRKFHREKAGLC", "length": 987, "header": "tr|A0AAA9T2L7-1|A0AAA9T2L7_BOVIN Isoform 1 of ATP-dependent DNA helicase DDX11 OS=Bos taurus OX=9913 GN=DDX11 PE=3 SV=1 CANONICAL=A0AAA9T2L7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N5S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#A0A3Q1N5S6-1", "sequence": { "sequence": "MADETQEAGGIHFPFPFTPYAIQKDFMAALYQVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKRQEEERLLGAGAPASHNGLAPALGLPSSCQGSPGTPGATGEPDWITQFVQKKEERDLVDRLKEEQVRRKKREERLQQIRHNAKLRFAAKRMRQEDEETERLLRLSSEMLATGTEPEQVASGEEELVLAEYESDEEKGVPSGVDMDEDDLDEEHVTKIYYCSRTHSQLAQFVHEVQKSPFGQDTRLVSLGSRQNLCVNGDVRKLGSVQLINDRCVEMQRSKHERKSITEEEEPTRRRRRQEPRATCPFYSYERLQLLRDEVLVGVKDVEQLVALGEEAQACPYYGGRFAIPAAQLVVLPYQMLLHAPTRQAAGIRLQGQVVVIDEAHNLIDTITNIHSVEVRGSQLCQAHSQLLQYTERYGKRLKAKNLMYIKQLLYLLEKFVAVLGGNIKQNPNTQSLSQAGTELKTINDFLFQSKIDNINLFKVRRYCEKSKISRKLLGFTERYGAVLVPSMEQPKLSGFQDFLQSLQPGAMAAPAAPVEVGEDRSPRPASPLMHVEGFLEALTTANQDGRVILSRQGSLSQSSLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFREQLLAGAGVEAERVVEFSCGHVIPPDHILPLIICSGPSNQMLDFTYQKRGLPQMIFQEPRKANRVEQVLLEYSRCIKHCGQAQGTETGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIMSPELQEKMAYLDQTLPRGPGQARPGKVLVENLCMKAVNQSIGRAIRHQKDFASIVLLDQRYASPAIQAKLPAWIRDRVEVKATFGPAFAALRKFHREKAGLC", "length": 856, "header": "tr|A0A3Q1N5S6-1|A0AAA9T2L7_BOVIN Computationally mapped isoform of ATP-dependent DNA helicase DDX11 OS=Bos taurus OX=9913 GN=DDX11 PE=3 SV=3 CANONICAL=A0AAA9T2L7-1" }, "locus": { "chromosome": "5", "start_pos": 106997803, "end_pos": 106973047, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073527.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073527.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065618.3", "url": "https://www.ensembl.org/id/ENSBTAP00000065618.3" } ] } }, { "isoform_ac": "A0AAA9T2L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#A0AAA9T2L7-1", "sequence": { "sequence": "METEPGTSLPRKRSGATRGPAPPSPGVRMRNAGWVGERAARRAALEDADTGEEPEFQVQRRPPGLLAGLASAEQPSRRGRIMADETQEAGGIHFPFPFTPYAIQKDFMAALYQVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKRQEEERLLGAGAPASHNGLAPALGLPSSCQGSPGTPGATGEPDWITQFVQKKEERDLVDRLKEEQVRRKKREERLQQIRHNAKLRFAAKRMRQEDEETERLLRLSSEMLATGTEPEQVASGEEELVLAEYESDEEKGVPSGVDMDEDDLDEEHVTKIYYCSRTHSQLAQFVHEVQKSPFGQDTRLVSLGSRQNLCVNGDVRKLGSVQLINDRCVEMQRSKHERKSITEEEEPTRRRRRQEPRATCPFYSYERLQLLRDEVLVGVKDVEQLVALGEEAQACPYYGGRFAIPAAQLVVLPYQMLLHAPTRQAAGIRLQGQVVVIDEAHNLIDTITNIHSVEVRGSQLCQAHSQLLQYTERYGKRLKAKNLMYIKQLLYLLEKFVAVLGGNIKQNPNTQSLSQAGTELKTINDFLFQSKIDNINLFKVRRYCEKSKISRKLLGFTERYGAVLVPSMEQPKLSGFQDFLQSLQPGAMAAPAAPVEVGEDRSPRPASPLMHVEGFLEALTTANQDGRVILSRQGSLSQSSLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFREQLLAGAGVEAERVVEFSCGHVIPPDHILPLIICSGPSNQMLDFTYQKRGLPQMMDETGRILCNLCNVVPGGVVCFFPSYEYQHQVCTHWEKSGLLARLTIRKKIFQEPRKANRVEQVLLEYSRCIKHCGQAQGTETGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIMSPELQEKMAYLDQTLPRGPGQARPGKVLVENLCMKAVNQSIGRAIRHQKDFASIVLLDQRYASPAIQAKLPAWIRDRVEVKATFGPAFAALRKFHREKAGLC", "length": 987, "header": "tr|A0AAA9T2L7-1|A0AAA9T2L7_BOVIN Isoform 1 of ATP-dependent DNA helicase DDX11 OS=Bos taurus OX=9913 GN=DDX11 PE=3 SV=1 CANONICAL=A0AAA9T2L7-1" }, "locus": { "chromosome": "5", "start_pos": 106997803, "end_pos": 106967329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122164.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122164.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093039.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093039.1" } ] } }, { "isoform_ac": "E1BL06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7/entry#E1BL06-1", "sequence": { "sequence": "MADETQEAGGIHFPFPFTPYAIQKDFMAALYQVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKRQEEERLLGAGAPASHNGLAPALGLPSSCQGSPGTPGATGEPDWITQFVQKKEERDLVDRLKEEQVRRKKREERLQQIRHNAKLRFAAKRMRQEDEETERLLRLSSEMLATGTEPEQVASGEEELVLAEYESDEEKGVPSGVDMDEDDLDEEHVTKIYYCSRTHSQLAQFVHEVQKSPFGQDTRLVSLGSRQNLCVNGDVRKLGSVQLINDRCVEMQRSKHERKSITEEEEPTRRRRRQEPRATCPFYSYERLQLLRDEVLVGVKDVEQLVALGEEAQACPYYGGRFAIPAAQLVVLPYQMLLHAPTRQAAGIRLQGQVVVIDEAHNLIDTITNIHSVEVRGSQLCQAHSQLLQYTERYGKRLKAKNLMYIKQLLYLLEKFVAVLGGNIKQNPNTQSLSQAGTELKTINDFLFQSKIDNINLFKVRRYCEKSKISRKLLGFTERYGAVLVPSMEQPKLSGFQDFLQSLQPGAMAAPAAPVEVGEDRSPRPASPLMHVEGFLEALTTANQDGRVILSRQGSLSQSSLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPVSDFREQLLAGAGVEAERVVEFSCGHVIPPDHILPLIICSGPSNQMLDFTYQKRGLPQMMDETGRILCNLCNVVPGGVVCFFPSYEYQHQVCTHWEKSGLLARLTIRKKIFQEPRKANRVEQVLLEYSRCIKVCGHGGHALPQHHVSRAAGEDGLSGPDTSQRPRPGPPWEGAGGEPVHEGCQPVHRQGHQAPEGLCQHSAPGPTVRLPSHPGQAAGLDPGPRGGQSHLWPCLCCSAEVPSRESWPLLTGGHTAAWSPGPPFTCPWATSS", "length": 895, "header": "tr|E1BL06-1|E1BL06_BOVIN Computationally mapped isoform of DEAD/H-box helicase 11 OS=Bos taurus OX=9913 GN=DDX11 PE=3 SV=4 CANONICAL=A0AAA9T2L7-1" }, "locus": { "chromosome": "5", "start_pos": 106997871, "end_pos": 106973047, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009329.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009329.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009329.7", "url": "https://www.ensembl.org/id/ENSBTAP00000009329.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 185, "start_aa": "Thr", "end_pos": 185, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr185", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "id": "GO:0016818", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016818", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "iron-sulfur cluster binding", "id": "GO:0051536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051536", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "5'-3' DNA helicase activity", "id": "GO:0043139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "nucleobase-containing compound metabolic process", "id": "GO:0006139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" }, { "name": "establishment of sister chromatid cohesion", "id": "GO:0034085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 865, "end_pos": 867, "annotation": "n_glycosylation_sequon" }, { "start_pos": 923, "end_pos": 925, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O 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"https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": 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"activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": 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"evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": 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} ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", 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"id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": 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"evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": 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{ "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": 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"gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": 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"ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { 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"uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": 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"MCPETSKLAVVAADDESSHSSVSSVPLTLGLLREEGLEPWPTVSTMILRLLLALNFFPSIQVAENKILVKQSPMLVVNDNEVNLSCKYTYNLFSKEFRASLYKGADSAVEVCAVNGNHSHPLQSTNKEFNCTVKVGNETVTFYLQDLYVNQTDIYFCKLEVLYPPPYIDNEKSNGTIIHVKEKHLCPSPRSPESSKPFWALVVVNGVLVFYSLLVTVALSNCWMKNKRNRMLQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS", "length": 265, "header": "tr|A0AAA9T3U9-1|A0AAA9T3U9_BOVIN Isoform 1 of T-cell-specific surface glycoprotein CD28 OS=Bos taurus OX=9913 GN=CD28 PE=4 SV=1 CANONICAL=A0AAA9T3U9-1" }, "locus": { "chromosome": "2", "start_pos": 91939646, "end_pos": 91906199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116493.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116493.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091322.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091322.1" } ] } }, { "isoform_ac": "A0AAA9TZV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9/entry#A0AAA9TZV7-1", "sequence": { "sequence": 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"ILRLLLALNFFPSIQVAEKHLCPSPRSPESSKPFWALVVVNGVLVFYSLLVTVALSNCWMKNKRNRMLQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS", "length": 101, "header": "tr|A0ABI0NU78-1|A0ABI0NU78_BOVIN Computationally mapped isoform of CD28 molecule OS=Bos taurus OX=9913 GN=CD28 PE=4 SV=1 CANONICAL=A0AAA9T3U9-1" }, "locus": { "chromosome": "2", "start_pos": 91939646, "end_pos": 91906337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150016.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150016.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104669.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104669.1" } ] } }, { "isoform_ac": "A0ABI0P3T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9/entry#A0ABI0P3T0-1", "sequence": { "sequence": "MPWEDRSSCHHSTAGPHHLQERAQALNCAHFANLVFNNSGAANGENKILVKQSPMLVVNDNEVNLSCKYTYNLFSKEFRASLYKGADSAVEVCAVNGNHSHPLQSTNKEFNCTVKVGNETVTFYLQDLYVNQTDIYFCKLEVLYPPPYIDNEKSNGTIIHVKEKHLCPSPRSPESSKPFWALVVVNGVLVFYSLLVTVALSNCWMKNKRNRMLQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS", "length": 246, "header": "tr|A0ABI0P3T0-1|A0ABI0P3T0_BOVIN Computationally mapped isoform of T-cell-specific surface glycoprotein CD28 OS=Bos taurus OX=9913 GN=CD28 PE=4 SV=1 CANONICAL=A0AAA9T3U9-1" }, "locus": { "chromosome": "2", "start_pos": 91939646, "end_pos": 91912381, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136781.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136781.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105307.1" } ] } }, { "isoform_ac": "F1MXF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9/entry#F1MXF4-1", "sequence": { "sequence": "MLSSPLLSLLPSPSLSPSLSFLKNKILVKQSPMLVVNDNEVNLSCKYTYNLFSKEFRASLYKGADSAVEVCAVNGNHSHPLQSTNKEFNCTVKVGNETVTFYLQDLYVNQTDIYFCKLEVLYPPPYIDNEKSNGTIIHVKEKHLCPSPRSPESSKPFWALVVVNGVLVFYSLLVTVALSNCWMKNKRNRMLQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS", "length": 224, "header": "tr|F1MXF4-1|A0AAA9T3U9_BOVIN Computationally mapped isoform of T-cell-specific surface glycoprotein CD28 OS=Bos taurus OX=9913 GN=CD28 PE=4 SV=3 CANONICAL=A0AAA9T3U9-1" }, "locus": { "chromosome": "2", "start_pos": 91939646, "end_pos": 91932631, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009792.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009792.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009792.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009792.5" } ] } }, { "isoform_ac": "F1N4W3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9/entry#F1N4W3-1", "sequence": { "sequence": "MFPPTTRFLGTLKRVLVSYSSLKCLLLLMPWEDRSSCHHSTENKILVKQSPMLVVNDNEVNLSCKYTYNLFSKEFRASLYKGADSAVEVCAVNGNHSHPLQSTNKEFNCTVKVGNETVTFYLQDLYVNQTDIYFCKLEVLYPPPYIDNEKSNGTIIHVKEKHLCPSPRSPESSKPFWALVVVNGVLVFYSLLVTVALSNCWMKNKRNRMLQSDYMNMTPRRPGPTRRHYQPYAPARDFAAYRS", "length": 243, "header": "tr|F1N4W3-1|F1N4W3_BOVIN Computationally mapped isoform of T-cell-specific surface glycoprotein CD28 OS=Bos taurus OX=9913 GN=CD28 PE=4 SV=3 CANONICAL=A0AAA9T3U9-1" }, "locus": { "chromosome": "2", "start_pos": 91939646, "end_pos": 91912297, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054530.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054530.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052588.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052588.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": 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involved in cell adhesion", "id": "GO:0098636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098636", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "T cell activation", "id": "GO:0042110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042110", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "positive regulation of T cell proliferation", "id": "GO:0042102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U9" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3U9", "url": 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"MLFYPCVLDHLFFGPNPEGGKRGVDGRGKRAGENRGWEKDGPFWKEARIPECLRVCVCVCVRVCGVFWPGAGCTVAGCFCVPASMCLFVPWSQSSILRPQGVQPGAQAWATMALPAWPATLPHTLLLLPALLSSGWGELAPQIDGQTWAERALRENERHAFTCRVAGGLGTPRLAWYLDGQLQEASTSRLLSVGREAFSGGTSTFTVTAQRAQHELNCSLQDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVILFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLPHNLSVVATNDVGVTSSSLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKVSNVRLPRENMSLPSNLQLNDLAPGCRGTPSKLFAPALSSEVLLRKKKTLDLRRPRPHRAHASSRAPPPLPPHRETSGPADGSGQQPARPSGPGAWWPPHQPRFHPPSNAGLHLPGVQCEQ", "length": 517, "header": "tr|A0AAA9T141-1|A0AAA9T141_BOVIN Isoform 1 of Transmembrane protein 25 OS=Bos taurus OX=9913 GN=TMEM25 PE=4 SV=2 CANONICAL=A0AAA9T141-1" }, "isoforms": [ { "isoform_ac": "A0A452DJG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T141/entry#A0A452DJG5-1", "sequence": { "sequence": "MRQQPIKLSVRPTPACVRVRSPSLSGMGAQGSPAREAAPDQQPWKKGPSGRDRASIGPAWRSPGPCGGLRCSAGLSSRSGCARGVSQPGAQAWATMALPAWPATLPHTLLLLPALLSSGWGELAPQIDGQTWAERALRENERHAFTCRVAGGLGTPRLAWYLDGQLQEASTSRLLSVGREAFSGGTSTFTVTAQRAQHELNCSLQDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVILFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLPHNLSVVATNDVGVTSSSLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKVSNVRLPRENMSLPSNLQLNDLAPGCRGKPADRQMAQDNSRPDLLDPEPGGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL", "length": 460, "header": "tr|A0A452DJG5-1|A0AAA9T141_BOVIN Computationally mapped isoform of Transmembrane protein 25 OS=Bos taurus OX=9913 GN=TMEM25 PE=4 SV=2 CANONICAL=A0AAA9T141-1" }, "locus": { "chromosome": "15", "start_pos": 29201914, "end_pos": 29198390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019835.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019835.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019835.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019835.4" } ] } }, { "isoform_ac": "A0AAA9T141-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T141/entry#A0AAA9T141-1", "sequence": { "sequence": "MLFYPCVLDHLFFGPNPEGGKRGVDGRGKRAGENRGWEKDGPFWKEARIPECLRVCVCVCVRVCGVFWPGAGCTVAGCFCVPASMCLFVPWSQSSILRPQGVQPGAQAWATMALPAWPATLPHTLLLLPALLSSGWGELAPQIDGQTWAERALRENERHAFTCRVAGGLGTPRLAWYLDGQLQEASTSRLLSVGREAFSGGTSTFTVTAQRAQHELNCSLQDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVILFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLPHNLSVVATNDVGVTSSSLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKVSNVRLPRENMSLPSNLQLNDLAPGCRGTPSKLFAPALSSEVLLRKKKTLDLRRPRPHRAHASSRAPPPLPPHRETSGPADGSGQQPARPSGPGAWWPPHQPRFHPPSNAGLHLPGVQCEQ", "length": 517, "header": "tr|A0AAA9T141-1|A0AAA9T141_BOVIN Isoform 1 of Transmembrane protein 25 OS=Bos taurus OX=9913 GN=TMEM25 PE=4 SV=2 CANONICAL=A0AAA9T141-1" }, "locus": { "chromosome": "15", "start_pos": 29201898, "end_pos": 29198691, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096018.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096018.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090279.2", "url": "https://www.ensembl.org/id/ENSBTAP00000090279.2" } ] } }, { "isoform_ac": "A0AAA9T7F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T141/entry#A0AAA9T7F6-1", "sequence": { "sequence": "ENPGPSGTGPHPGHNSTNPPPALPRLHYVLGWGELAPQIDGQTWAERALRENERHAFTCRVAGGLGTPRLAWYLDGQLQEASTSRLLSVGREAFSGGTSTFTVTAQRAQHELNCSLQDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVILFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLPHNLSVVATNDVGVTSSSLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKVSNVRLPRENMSLPSNLQLNDLAPGCRGKPADRQMAQDNSRPDLLDPEPGGLLTSRAMPFRSLVSGTGIEPGLWE", "length": 367, "header": "tr|A0AAA9T7F6-1|A0AAA9T7F6_BOVIN Computationally mapped isoform of Transmembrane protein 25 OS=Bos taurus OX=9913 GN=TMEM25 PE=4 SV=1 CANONICAL=A0AAA9T141-1" }, "locus": { "chromosome": "15", "start_pos": 29208586, "end_pos": 29199442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097765.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097765.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092537.1" } ] } }, { "isoform_ac": "F6R3D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T141/entry#F6R3D6-1", "sequence": { "sequence": "MGEGSGQEKTGVGRKTVPFGKRRVYPSVCVCVCACACVCVVYFGLVRAARLLVVSVYLRACACLFLGVRAQFCARRVYRLHYVLGWGELAPQIDGQTWAERALRENERHAFTCRVAGGLGTPRLAWYLDGQLQEASTSRLLSVGREAFSGGTSTFTVTAQRAQHELNCSLQDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVILFALVRANPPANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLPHNLSVVATNDVGVTSSSLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLISSDSNNLKVSNVRLPRENMSLPSNLQLNDLAPGCRGKPADRQMAQDNSRPDLLDPEPGGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL", "length": 426, "header": "tr|F6R3D6-1|F6R3D6_BOVIN Computationally mapped isoform of Transmembrane protein 25 OS=Bos taurus OX=9913 GN=TMEM25 PE=4 SV=1 CANONICAL=A0AAA9T141-1" }, "locus": { "chromosome": "15", "start_pos": 29201914, "end_pos": 29198764, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017194.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017194.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017194.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017194.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T141", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T141" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T141", "url": 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"Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 230, "end_pos": 232 }, { "start_pos": 273, "end_pos": 275 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 303, "end_pos": 305 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 406, "end_pos": 408 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ 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"UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.52", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] }, { "name": "Beta-N-acetylhexosaminidase", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] }, { "name": "Beta-hexosaminidase D", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] }, { "name": "Hexosaminidase domain-containing protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] }, { "name": "N-acetyl-beta-galactosaminidase", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates.", "evidence": [ { "database": "UniProtKB", "id": "F1MED7", "url": "https://www.uniprot.org/uniprotkb/F1MED7#function" }, { "database": "UniProtKB", "id": "ARBA00056985", "url": "https://www.uniprot.org/uniprotkb/ARBA00056985#function" }, { "database": "UniProtKB", "id": "A0AAA9RSV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSV2#function" }, { "database": "UniProtKB", "id": "A0AAA9SCS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS2#function" }, { "database": "UniProtKB", "id": "A0AAA9STT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT5#function" }, { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEXD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8", "locus": { "chromosome": "19", "start_pos": 50123881, "end_pos": 50146056, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018175", "url": "https://www.ensembl.org/id/ENSBTAG00000018175" } ] } } ], "crossref": [ { "id": "A0AAA9T1D8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1D8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018175", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018175", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06565", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06565", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR015883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR21040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21040:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21040:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00728", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00728", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1D8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MED7", "url": "https://www.uniprot.org/uniprotkb/F1MED7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MED7-1", "url": "https://www.uniprot.org/uniprotkb/F1MED7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRSEGAGSFPGSDILALVTQVSLHLCSSVDALLERDRYVTGWFSPYHRRRKLIHPVMIEHIQPQALSLLARWNALAGELEAALQRIFYPDTVEEWLEENVHPSLQRLQALLQDLGSSADRGTRKRNLMWVSPTDTTLCGMKTRLQVKSPDPA", "length": 503, "header": "tr|A0AAA9T1D8-1|A0AAA9T1D8_BOVIN Isoform 1 of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=1 CANONICAL=A0AAA9T1D8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#A0AAA9RSV2-1", "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRSEGAGSFPGSDILALVTQVSLHLCSSVDALLERDRYVTGWFSPYHRRRKLIHPVMIEHIQPQALSLLARWNALAGELEAALQRIFYPDTVEEWLEENVHPSLQRLQALLQDLGEAASPRQDSAGTRI", "length": 480, "header": "tr|A0AAA9RSV2-1|A0AAA9T1D8_BOVIN Computationally mapped isoform of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=1 CANONICAL=A0AAA9T1D8-1" }, "locus": { "chromosome": "19", "start_pos": 50143855, "end_pos": 50124213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119859.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119859.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074784.1" } ] } }, { "isoform_ac": "A0AAA9SCS2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#A0AAA9SCS2-1", "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRSEGAGSFPGSDILALVTQVSLHLCSSVDALLERDRYVTGWFSPYHRRRKLIHPVMIEHIQPQALRCHEKLGHFLPERVEGHQMP", "length": 437, "header": "tr|A0AAA9SCS2-1|A0AAA9T1D8_BOVIN Computationally mapped isoform of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=1 CANONICAL=A0AAA9T1D8-1" }, "locus": { "chromosome": "19", "start_pos": 50143855, "end_pos": 50130879, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109016.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109016.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080093.1" } ] } }, { "isoform_ac": "A0AAA9STT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#A0AAA9STT5-1", "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRSEGAGSFPGSDILALVTQVSLHLCSSVDALLERDRYVTGWFSPYHRRRKLIHPVMIEHIQPQALRP", "length": 419, "header": "tr|A0AAA9STT5-1|A0AAA9T1D8_BOVIN Computationally mapped isoform of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=1 CANONICAL=A0AAA9T1D8-1" }, "locus": { "chromosome": "19", "start_pos": 50143855, "end_pos": 50124503, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124955.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124955.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088756.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088756.1" } ] } }, { "isoform_ac": "A0AAA9T1D8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#A0AAA9T1D8-1", "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRSEGAGSFPGSDILALVTQVSLHLCSSVDALLERDRYVTGWFSPYHRRRKLIHPVMIEHIQPQALSLLARWNALAGELEAALQRIFYPDTVEEWLEENVHPSLQRLQALLQDLGSSADRGTRKRNLMWVSPTDTTLCGMKTRLQVKSPDPA", "length": 503, "header": "tr|A0AAA9T1D8-1|A0AAA9T1D8_BOVIN Isoform 1 of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=1 CANONICAL=A0AAA9T1D8-1" }, "locus": { "chromosome": "19", "start_pos": 50143855, "end_pos": 50124697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095057.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095057.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091515.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091515.1" } ] } }, { "isoform_ac": "F1MED7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8/entry#F1MED7-1", "sequence": { "sequence": "MSGSSPFKMRLVHLDLKGAPPKVCYLSEIFPLFRALGANGILIEYEDMFPYEGHLRLLRAKHAYSPSEIKEILHLATLNELEVIPLVQTFGHMEFVLKHEALAHLREVARFPNTLNPHKEESLALVTAMIDQVMELHPGARWFHVGCDEVYYLGEGETSRQWLQQEPNSKAKLCLSHMEAVASHMRARYPTTTPLMWDDMLRDIPEDQLSGSRVPQLVEPVLWDYGADLDLHGKALLVEKYRKSGFSWLWAASAFKGATGVNQSLTPIEHHLRNHLQWLQVAGSVPADTLRGIILTGWQRYDHFSVLCELLPVGIPSLAVCLQALLHGDFAENVKARVENFLGISSLEEMSFRRYVTGWFSPYHRRRKLIHPVMIEHIQPQALSLLARWNALAGELEAALQRIFYPDTVEEWLEENVHPSLQRLQALLQDLGEAASPRQDSGQDP", "length": 445, "header": "tr|F1MED7-1|F1MED7_BOVIN Computationally mapped isoform of Hexosaminidase D OS=Bos taurus OX=9913 GN=HEXD PE=3 SV=4 CANONICAL=A0AAA9T1D8-1" }, "locus": { "chromosome": "19", "start_pos": 50143855, "end_pos": 50130291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024186.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024186.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024186.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024186.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" }, { "name": "extracellular vesicle", "id": "GO:1903561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903561", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "beta-N-acetylhexosaminidase activity", "id": "GO:0004563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004563", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" }, { "name": "hexosaminidase activity", "id": "GO:0015929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D8" }, { "id": "PF00728", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00728" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Glycoside hydrolase family 20 catalytic", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 205, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.52", "ec_name": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "3.2.1.52", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.52" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE7", "url": "https://www.uniprot.org/uniprotkb/F1MBE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE7-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDGGEWAGRVTGGSAFSLPSVADPQGRQTRSSRCVALIQVHHSHPAPFVRLVSSPFIKEKPKTRKARVGLPRTHRRVGLRRLEPATPHPWSSLQCFLVKLPVLPSVNPLQPARNCGLKGSRQPAEASGNTQTTSGPSDTPHTPCVQMRDQALRYRSIHTQLMEMVLTLQQTVEDHIMQLTTRPQQRDLALEEQWHGQAIREQEALLGRLLFQIVSFLPAGAPGDQSVQPPCTSTDSRGDVGGGQPVQANRQTGQMFYQESDFENTVISYDLSNRGIDISALYHLSFRDYDTYQGNKYHKDKNTLGYINLGTSENKLCTDLLAERLSQSDMTYVDEDLLQYTDWRGQPFLRKEVARFLTFYCKTPKPLDPENVVILNGCSAVFSALAMVLCDPGEAFLVPTPAYGGFAFSTHLYAKVKLVPVHLESQVTEANGYPFQLTVDKLEHTLLRAKIEGKKVRGLVLINPQNPLGDVYSQDSMMEYLEFAKKYNLHVIVDEMYMLSVFDEAITFHSVLSMKSLPDPNKTHVIWGASKDFCISGFRFGALYTHNREVASAMSCFGYLHSISGIAQYKLRQLLQDREWIDNIYLPSYHFRLQEAHRYVTRKLKASKVPFLNRGSGLYVWINLKQYLDPCTFEEELLLHRRFLDHKLILSPGKTFMCKEPGWFRLVFAARPHLLRNAMRRFQQVLVEQAQERTVKQLEDAMKEEVSTPQPEAPASPALRKS", "length": 723, "header": "tr|A0AAA9T1J8-1|A0AAA9T1J8_BOVIN Isoform 1 of 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like OS=Bos taurus OX=9913 GN=ACCSL PE=4 SV=1 CANONICAL=A0AAA9T1J8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWY0-1", "url": 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74173156, "end_pos": 74154004, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135064.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135064.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076987.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076987.1" } ] } }, { "isoform_ac": "A0AAA9T1J8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8/entry#A0AAA9T1J8-1", "sequence": { "sequence": "MRDGGEWAGRVTGGSAFSLPSVADPQGRQTRSSRCVALIQVHHSHPAPFVRLVSSPFIKEKPKTRKARVGLPRTHRRVGLRRLEPATPHPWSSLQCFLVKLPVLPSVNPLQPARNCGLKGSRQPAEASGNTQTTSGPSDTPHTPCVQMRDQALRYRSIHTQLMEMVLTLQQTVEDHIMQLTTRPQQRDLALEEQWHGQAIREQEALLGRLLFQIVSFLPAGAPGDQSVQPPCTSTDSRGDVGGGQPVQANRQTGQMFYQESDFENTVISYDLSNRGIDISALYHLSFRDYDTYQGNKYHKDKNTLGYINLGTSENKLCTDLLAERLSQSDMTYVDEDLLQYTDWRGQPFLRKEVARFLTFYCKTPKPLDPENVVILNGCSAVFSALAMVLCDPGEAFLVPTPAYGGFAFSTHLYAKVKLVPVHLESQVTEANGYPFQLTVDKLEHTLLRAKIEGKKVRGLVLINPQNPLGDVYSQDSMMEYLEFAKKYNLHVIVDEMYMLSVFDEAITFHSVLSMKSLPDPNKTHVIWGASKDFCISGFRFGALYTHNREVASAMSCFGYLHSISGIAQYKLRQLLQDREWIDNIYLPSYHFRLQEAHRYVTRKLKASKVPFLNRGSGLYVWINLKQYLDPCTFEEELLLHRRFLDHKLILSPGKTFMCKEPGWFRLVFAARPHLLRNAMRRFQQVLVEQAQERTVKQLEDAMKEEVSTPQPEAPASPALRKS", "length": 723, "header": "tr|A0AAA9T1J8-1|A0AAA9T1J8_BOVIN Isoform 1 of 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like OS=Bos taurus OX=9913 GN=ACCSL PE=4 SV=1 CANONICAL=A0AAA9T1J8-1" }, "locus": { "chromosome": "15", "start_pos": 74173073, "end_pos": 74152302, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135565.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135565.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091593.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091593.1" } ] } }, { "isoform_ac": "F1MBE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8/entry#F1MBE7-1", "sequence": { "sequence": "MSGNKESGSRQPAEASGNTQTTSGPSDTPHTPCVQMRDQALRYRSIHTQLMEMVLTLQQTVEDHIMQLTTRPQQRDLALEEQWHGQAIREQEALLGRLLFQIVSFLPAGAPGDQSVQPPCTSTDSRGDVGGGQPVQANRQTGQMFYQESDFENTVISYDLSNRGIDISALYHLSFRDYDTYQGNKYHKDKNTLGYINLGTSENKLCTDLLAERLSQSDMTYVDEDLLQYTDWRGQPFLRKEVARFLTFYCKTPKPLDPENVVILNGCSAVFSALAMVLCDPGEAFLVPTPAYGGFAFSTHLYAKVKLVPVHLESQVTEANGYPFQLTVDKLEHTLLRAKIEGKKVRGLVLINPQNPLGDVYSQDSMMEYLEFAKKYNLHVIVDEMYMLSVFDEAITFHSVLSMKSLPDPNKTHVIWGASKDFCISGFRFGALYTHNREVASAMSCFGYLHSISGIAQYKLRQLLQDREWIDNIYLPSYHFRLQEAHRYVTRKLKASKVPFLNRGSGLYVWINLKQYLDPCTFEEELLLHRRFLDHKLILSPGKTFMCKEPGWFRLVFAARPHLLRNAMRRFQQVLVEQAQERTVKQLEDAMKEEVSTPQPEAPASPALRKS", "length": 611, "header": "tr|F1MBE7-1|A0AAA9T1J8_BOVIN Computationally mapped isoform of 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like OS=Bos taurus OX=9913 GN=ACCSL PE=4 SV=3 CANONICAL=A0AAA9T1J8-1" }, "locus": { "chromosome": "15", "start_pos": 74173073, "end_pos": 74154004, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015998.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015998.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015998.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015998.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1J8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8" } ], "pmid": "" }, { "name": "transaminase activity", "id": "GO:0008483", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008483", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1J8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid metabolic process", "id": "GO:0006520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006520", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1J8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1J8" }, { "id": "PF00155", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00155" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminotransferase class I/classII large", "eco_id": "ECO_0000259", "start_pos": 308, "end_pos": 679, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 522, "end_pos": 524 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T102-1", "uniprot_ac": "A0AAA9T102", "uniprot_id": "A0AAA9T102_BOVIN", "mass": { "chemical_mass": 67836.0, "monoisotopic_mass": 67836.0 }, "refseq": { "ac": "XP_005201966", "name": "centrosomal protein of 70 kDa isoform X7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201966" }, "gene_names": [ { "name": "CEP70", "type": "recommended", "evidence": [ { "id": "A0AAA9T102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ] }, { "name": "CEP70", "type": "synonym", "evidence": [ { "id": "XP_005201966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201966" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 70 kDa", "type": "recommended", "evidence": [ { "id": "A0AAA9T102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 70 kDa isoform X7", "type": "synonym", "evidence": [ { "id": "XP_005201966", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201966" } ] } ], "function": [ { "annotation": "Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RX53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX53#function" }, { "database": "UniProtKB", "id": "ARBA00025273", "url": "https://www.uniprot.org/uniprotkb/ARBA00025273#function" }, { "database": "UniProtKB", "id": "A0AAA9S6D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6D1#function" }, { "database": "UniProtKB", "id": "A0AAA9S9C4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C4#function" }, { "database": "UniProtKB", "id": "A0AAA9SER1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SER1#function" }, { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102#function" }, { "database": "UniProtKB", "id": "A0AAA9TFF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF1#function" }, { "database": "UniProtKB", "id": "A0AAA9TJY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJY8#function" }, { "database": "UniProtKB", "id": "A0AAA9U2J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2J3#function" }, { "database": "UniProtKB", "id": "F1ME79", "url": "https://www.uniprot.org/uniprotkb/F1ME79#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102", "locus": { "chromosome": "1", "start_pos": 130600562, "end_pos": 130518825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018538", "url": "https://www.ensembl.org/id/ENSBTAG00000018538" } ] } } ], "crossref": [ { "id": "A0AAA9T102", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T102", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018538", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018538", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100301027", "url": "https://www.ncbi.nlm.nih.gov/gene/100301027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100301027", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100301027", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR14594", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14594", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14594:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14594:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27977", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27977", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005201966", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201966", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RX53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9C4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SER1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SER1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SER1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SER1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T102-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2J3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2J3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2J3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME79", "url": "https://www.uniprot.org/uniprotkb/F1ME79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME79-1", "url": "https://www.uniprot.org/uniprotkb/F1ME79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 578, "header": "tr|A0AAA9T102-1|A0AAA9T102_BOVIN Isoform 1 of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=2 CANONICAL=A0AAA9T102-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RX53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9RX53-1", "sequence": { "sequence": "MGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 616, "header": "tr|A0AAA9RX53-1|A0AAA9T102_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130598372, "end_pos": 130523613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087847.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087847.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078072.1" } ] } }, { "isoform_ac": "A0AAA9S6D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9S6D1-1", "sequence": { "sequence": "MDYSPPGSSVHGIFPGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 611, "header": "tr|A0AAA9S6D1-1|A0AAA9T102_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130598372, "end_pos": 130526517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129589.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129589.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080757.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080757.1" } ] } }, { "isoform_ac": "A0AAA9S9C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9S9C4-1", "sequence": { "sequence": "MGFPHDSDGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 604, "header": "tr|A0AAA9S9C4-1|A0AAA9T102_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130598372, "end_pos": 130522760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113665.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113665.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080530.1" } ] } }, { "isoform_ac": "A0AAA9SER1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9SER1-1", "sequence": { "sequence": "MTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILE", "length": 559, "header": "tr|A0AAA9SER1-1|A0AAA9T102_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=2 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130597315, "end_pos": 130531449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120553.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120553.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084624.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084624.2" } ] } }, { "isoform_ac": "A0AAA9T102-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9T102-1", "sequence": { "sequence": "MTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 578, "header": "tr|A0AAA9T102-1|A0AAA9T102_BOVIN Isoform 1 of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=2 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130598372, "end_pos": 130531449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125954.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125954.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092479.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092479.2" } ] } }, { "isoform_ac": "A0AAA9TFF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9TFF1-1", "sequence": { "sequence": "MERIISSHYLLVSKVAVKKSAGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILE", "length": 598, "header": "tr|A0AAA9TFF1-1|A0AAA9TFF1_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130597315, "end_pos": 130523613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112191.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112191.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096860.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096860.1" } ] } }, { "isoform_ac": "A0AAA9TJY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9TJY8-1", "sequence": { "sequence": "MGFPHDSDERIISSHYLLVSKVAVKKSAGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPAVRKLKILSY", "length": 643, "header": "tr|A0AAA9TJY8-1|A0AAA9TJY8_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130598372, "end_pos": 130522760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096413.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096413.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097490.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097490.1" } ] } }, { "isoform_ac": "A0AAA9U2J3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#A0AAA9U2J3-1", "sequence": { "sequence": "MERIISSHYLLVSKVAVKKSAGNSIFYCQSQLLLTLQKKLYLQQPLKPRSPANHQIRLMTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILGKIFVGGG", "length": 624, "header": "tr|A0AAA9U2J3-1|A0AAA9U2J3_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=1 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130596487, "end_pos": 130523613, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102456.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102456.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103764.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103764.1" } ] } }, { "isoform_ac": "F1ME79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102/entry#F1ME79-1", "sequence": { "sequence": "MTEKQREEAEWENINVLLMMHGLKPLSLVKRTDMKDLIIFDKQSSQTMRENLKTMMEETSRQQNMIQELIETNKQLKNELQQQQSRAADQEQRANDLEQIMESVKSKIGEMEDESVNRVCQQQNKIKELQKEHKVLQAKCEHYKIKRKEQQETIAALQKDIYRLTQEEEERIITQNRVFSYLCKRVPHTVLDKQLLCLIDYYESKIRKFHKQRLYKEDESQSEEEDYRSLSASPTYNGLLMSLQNQLKESKTKIDVLLSEKLNLQKELETRPTQHELRLYKQQVKKLEKALKKNIKLQNIISQKKAEDKEGKDEPSKDNQQQALIDQRYFQVLSSINSIIHNPRAPVIIYKQSKGTAQHFNRDLVQDCGFEHLVPIIEMWADQLASLKDLYKSLKILSTELVPWHNLKKQDENEGVRVEDLLFIVDTMLEEVENKAKDSNMPDFHILRAIVSHFQKLFDVPSLTGVYPRMNEVYTRLGELNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEKIMQVLGPEDLQSIIHKLEEHEEFFPAFQAFTNDLLKILEIDDLDAIVPALRW", "length": 572, "header": "tr|F1ME79-1|F1ME79_BOVIN Computationally mapped isoform of Centrosomal protein of 70 kDa OS=Bos taurus OX=9913 GN=CEP70 PE=4 SV=4 CANONICAL=A0AAA9T102-1" }, "locus": { "chromosome": "1", "start_pos": 130600219, "end_pos": 130531449, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050229.6", "url": "https://www.ensembl.org/id/ENSBTAT00000050229.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046962.5", "url": "https://www.ensembl.org/id/ENSBTAP00000046962.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100301027", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100301027", "resource": "KEGG Pathway" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" }, { "name": "regulation of microtubule cytoskeleton organization", "id": "GO:0070507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T102", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T102" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], 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"sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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Classification" ] }, { "id": "IPR050889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MSK0", "url": "https://www.orthodb.org/?gene=F1MSK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24166:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24166:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010814669", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T541", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T541-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSK0", "url": "https://www.uniprot.org/uniprotkb/F1MSK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSK0-1", "url": "https://www.uniprot.org/uniprotkb/F1MSK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSPTLTSAQKLDVDAYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYNMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTSATAKDGSYGAVTSPTSTLESRDSGIIATLTSYSENMERTKYVGESSKDLGSGGNLKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMAGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLAAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIDGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQQPPVQQQPPQQQLPEEAEPEPQHEDIYSVQDILEEEFLEQDVENVSIGLQTEARPSQGLPIIQSPPSSPAPRDSAYISGSPLGSHQVFDFRSSSSVGSPTRQSYQSSSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGPGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQPGLRLQPAKAQIVRSNQPSSAVHSSTVISTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPSEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSASSLTPTFRPPSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGGLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLTNGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV", "length": 2073, "header": "tr|A0AAA9T541-1|A0AAA9T541_BOVIN Isoform 1 of Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 OS=Bos taurus OX=9913 GN=TANC2 PE=3 SV=1 CANONICAL=A0AAA9T541-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541/entry#A0AAA9RXD7-1", "sequence": { "sequence": "MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSPTLTSAQKLDVDAYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYNMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTSATAKDGSYGAVTSPTSTLESRDSGIIATLTSYSENMERTKYVGESSKDLGSGGNLKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMAGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLAAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIDGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQQPPVQQQPPQQQLPEEAEPEPQHEDIYSVQDILEEEFLEQDVENVSIGLQTEARPSQGLPIIQSPPSSPAPRDSAYISGSPLGSHQVFDFRSSSSVGSPTRQSYQSSSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGPGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQPGLRLQPAKAQIVRSNQPSSAVHSSTVISTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPSEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSASSLTPTFRPPSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGGLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLTNGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV", "length": 2063, "header": "tr|A0AAA9RXD7-1|A0AAA9T541_BOVIN Computationally mapped isoform of Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 OS=Bos taurus OX=9913 GN=TANC2 PE=3 SV=1 CANONICAL=A0AAA9T541-1" }, "locus": { "chromosome": "19", "start_pos": 47758822, "end_pos": 47441495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089117.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089117.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075862.1" } ] } }, { "isoform_ac": "A0AAA9T541-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541/entry#A0AAA9T541-1", "sequence": { "sequence": "MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTAPLRKAKFVESPRIPESELGSPTLTSAQKLDVDAYCPGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYNMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTSATAKDGSYGAVTSPTSTLESRDSGIIATLTSYSENMERTKYVGESSKDLGSGGNLKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMAGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLAAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIDGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGCQTLPSRPRGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQQPPVQQQPPQQQLPEEAEPEPQHEDIYSVQDILEEEFLEQDVENVSIGLQTEARPSQGLPIIQSPPSSPAPRDSAYISGSPLGSHQVFDFRSSSSVGSPTRQSYQSSSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGPGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQPGLRLQPAKAQIVRSNQPSSAVHSSTVISTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPSEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSASSLTPTFRPPSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGGLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLTNGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV", "length": 2073, "header": "tr|A0AAA9T541-1|A0AAA9T541_BOVIN Isoform 1 of Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 OS=Bos taurus OX=9913 GN=TANC2 PE=3 SV=1 CANONICAL=A0AAA9T541-1" }, "locus": { "chromosome": "19", "start_pos": 47758822, "end_pos": 47441495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091649.1" } ] } }, { "isoform_ac": "F1MSK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541/entry#F1MSK0-1", "sequence": { "sequence": "MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQGGISTESDCAFEPDYAVPPLPVSEGMQHIRIMEGMSRSLPSSPLLTHQSISVRLQPVKKLTGDAEQELGPPPSVDEAANTLMTRLGFLLGEKVTEVQPGDQYNMEVQDENQTSAITQRISPCSTLTSSTASPPASSPCSTLPPVSTSATAKDGSYGAVTSPTSTLESRDSGIIATLTSYSENMERTKYVGESSKDLGSGGNLKPWQSQKSSMDSCLYRVDENMTASTYSLNKIPERNLETVLSQSVQSIPLYLMPRPNSVAATSSAHLEDLAYLDEQRHTPLRTSLRMPRQSMAGARTQQDLRVRFAPYRPPDISLKPLLFEVPSITTESVFVGRDWVFHEIDAQLQSSNASVNQGVVIVGNIGFGKTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTPEMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLAAYREQLLREPHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEAEFHKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLPFHRIFLDRLEENEAIDQDLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGYLVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAINAGSIDGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRSGHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGFLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKVSLLLNLSRCRRKMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNNREIQRLLLRVEEECRQMQQQPPVQQQPPQQQLPEEAEPEPQHEDIYSVQDILEEEFLEQDVENVSIGLQTEARPSQGLPIIQSPPSSPAPRDSAYISGSPLGSHQVFDFRSSSSVGSPTRQSYQSSSPALSPTHQNSHYRPSPPHTSPAHQGGSYRFSPPPVGGPGKEYPSPPPSPLRRGPQYRASPPAESMSVYRSQSGSPVRYQQETNVSQLPGRPKSPLSKMAQRPYQMPQLPVAVPQPGLRLQPAKAQIVRSNQPSSAVHSSTVISTGAYGQVAHSMASKYQSSQGDIGVSQSRLVYQGSIGGIVGDGRPVQHVQASLSAGAICQHGGLAKEDLPQRPSSAYRGGMRYSQTPQIGRSQSASYYPVCHSKLDLERSSSQLGSPDVSHLIRRPISVNPSEIKPHPPTPRPLLHSQSVGLRFSPSSNSISSASSLTPTFRPPSSIQQMEIPLKPAYDRSCDELSPVSPTQGGYPSEPTRSRTTPFMGIIDKTARTQQYPHLHQQNRTWAVSSVDTVLSPTSPGGLPQPESFSPPSSISNIAFYNKTNNAQNGHLLEDDYYSPHGMLTNGSRGDLLERVSQASSYPDVKVARTLPVAQAYQDNLYRQLSRDSRQGQTSPIKPKRPFVESNV", "length": 2026, "header": "tr|F1MSK0-1|A0AAA9T541_BOVIN Computationally mapped isoform of Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 OS=Bos taurus OX=9913 GN=TANC2 PE=3 SV=4 CANONICAL=A0AAA9T541-1" }, "locus": { "chromosome": "19", "start_pos": 47758822, "end_pos": 47441495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005565.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005565.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005565.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005565.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1912, "start_aa": "Thr", "end_pos": 1912, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1912", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T541", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T541", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of dendritic spine morphogenesis", "id": "GO:0061001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061001", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T541", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of postsynaptic density", "id": "GO:0098919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098919", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T541", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1285, "end_pos": 1287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1380, "end_pos": 1382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1505, "end_pos": 1507, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1652, "end_pos": 1654, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1948, "end_pos": 1950, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1987, "end_pos": 1989, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2011, "end_pos": 2013, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 701, "end_pos": 703, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 821, "end_pos": 823, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" }, { "id": "PF25520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TANC1/2-like AAA+ ATPase lid", "eco_id": "ECO_0000259", "start_pos": 672, "end_pos": 766, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T541" }, { "id": "PF25521", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25521" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TANC1/2-like winged helix", "eco_id": "ECO_0000259", "start_pos": 768, "end_pos": 920, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1912 ], "snv_sites": [], 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"https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ] } ], "protein_names": [ { "name": "Adenylyl cyclase-associated protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T3I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1", "locus": { "chromosome": "23", "start_pos": 39867516, "end_pos": 40002509, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016924", "url": "https://www.ensembl.org/id/ENSBTAG00000016924" } ] } } ], "crossref": [ { "id": "A0AAA9T3I1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3I1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016924", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016924", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013912", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013912", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PISDHIH", "url": "https://omabrowser.org/oma/group/PISDHIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MG38", "url": "https://www.orthodb.org/?gene=A0A3Q1MG38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N715", "url": "https://www.orthodb.org/?gene=F1N715", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10652:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10652:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MG38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N715", "url": "https://www.uniprot.org/uniprotkb/F1N715", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N715-1", "url": "https://www.uniprot.org/uniprotkb/F1N715-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 486, "header": "tr|A0AAA9T3I1-1|A0AAA9T3I1_BOVIN Isoform 1 of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MG38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0A3Q1MG38-1", "sequence": { "sequence": "MEHCEIVMAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 493, "header": "tr|A0A3Q1MG38-1|A0A3Q1MG38_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=2 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39982332, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076932.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076932.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069509.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069509.2" } ] } }, { "isoform_ac": "A0AAA9RZI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0AAA9RZI7-1", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 422, "header": "tr|A0AAA9RZI7-1|A0AAA9T3I1_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39979275, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121422.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121422.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076752.1" } ] } }, { "isoform_ac": "A0AAA9S3X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0AAA9S3X2-1", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 226, "header": "tr|A0AAA9S3X2-1|A0AAA9T3I1_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39979275, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131534.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131534.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077973.1" } ] } }, { "isoform_ac": "A0AAA9SIP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0AAA9SIP2-1", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQEGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 374, "header": "tr|A0AAA9SIP2-1|A0AAA9T3I1_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39979275, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122956.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122956.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086116.1" } ] } }, { "isoform_ac": "A0AAA9STF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0AAA9STF6-1", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHNDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 460, "header": "tr|A0AAA9STF6-1|A0AAA9T3I1_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39979275, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109393.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109393.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089707.1" } ] } }, { "isoform_ac": "A0AAA9T3I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#A0AAA9T3I1-1", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 486, "header": "tr|A0AAA9T3I1-1|A0AAA9T3I1_BOVIN Isoform 1 of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=1 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39979275, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108539.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108539.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090251.1" } ] } }, { "isoform_ac": "F1N715-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1/entry#F1N715-1", "sequence": { "sequence": "MWRICRMAEMQGLMERLERAVGRLELLSAGSHRPPGDCGEINGVNGGVAPSVEAFDKLMNSMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSTMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPLLFESEGIKEPSSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPNLRAHGGQSPSPTKSHTPGPKSPQSHPSKKHTPVLELEGKKWRVEYQEDRNDLVISETALRQVAYIFKCGKSTLQIKGKINSIIIDNCKKFGLVFDNVVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGAKLITEPTEIMVSERPPKPLT", "length": 492, "header": "tr|F1N715-1|F1N715_BOVIN Computationally mapped isoform of Adenylyl cyclase-associated protein OS=Bos taurus OX=9913 GN=CAP2 PE=3 SV=3 CANONICAL=A0AAA9T3I1-1" }, "locus": { "chromosome": "23", "start_pos": 39982784, "end_pos": 39867878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022510.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022510.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022510.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022510.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IXA9-1", "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "cap2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEALVGRLERAVVRLEAVAVKLQSCPGGLINGDISAVINGGESQSMEAFDRLLSGSVSEYVQSSAAIGGDVAKHAEMVNNALQVQRTLLKMAMTHQEPAKTELADLLRPLSDQIQAVQNFREKNRGSSLFNHLSAVSESIPALGWVAVCQKPGPYVKEMNDAAMFYTNRVLKDFKDTDARHVEWVRSYLSIWTDLQTFIREHHCTGLIWSKTGPKAPPSLLSAPLLPPPPPPPPPMMIDSCSSPADASSVQHAALFAQLNQGEEITKGLKHVCDEQKTHKNPNLRSQSGKTHHDSPSKTQSSSSSNPARKHPPVLELEGKKWRVEYQDQCAELLIEDTELRQVVYVFSCSGSTLQVKGKVNSIIVDNCKKLGLVFDNVVGIVEIINSRDIQLQVMGKVPTISINKTEGCHVYLSKDSLDCEIVSAKSSEMNILVPEGEDDYREFPVPEQFKTVWDGSSLVTEPTKIAG", "length": 468 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8C2MYE4-1", "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "Cap2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MADMLGLVERLECAVNRLEQLSAGPCGPPGDCGEVNGVNGGVAPSVEAFDKLVNSMVAEFLKKSRVLSGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENEVAVLLKPISEKIQEIQTFRERNRGSSMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSQLQAYIKEHHTTGLTWSKTGPVASTASVFSVFSSGPGLPPPPPPPPPPGPPPLFENEGKNEESSPSRSALFAQLNQGEAITKGLRHVTDDQKIYKNPSLRAQGQTRSPTKTYTPSPTSPKSNSPQKHAPVLELEGKKWRVEYHEDKNDLVISETELKQVAYIFKCEKSTLQIKGKINSITVDNCKKFGLVFDNVVGIVEVINSKDIQIQVIGRVPTISINKTEGCHLYLSEDALDCEIVSAKSSEMNVLIPQGDDYREFPIPEQFKTVWDGSKLVTEPAEIMA", "length": 476 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BZ03-1", "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "CAP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAENHGLMERLEKAVTRLESLFSDSQRSGGMECDAMNGVNGSIAPYVEAFDRLLNGSVAEFLRYSKILEGDVKTHAEMVRAAFQAQRSFLVLASQCQEPQENEVAVLLKPISEKIQEIQNFRERNRGSKMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDTRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASPTSMRSVLTSGSCLSSPPPPPPPPPGPPPIFDTETPPKDEGTASRSALFAQLNQGEAITKGLRHVSDDQKTHKNPSLRAQGPPARSPTKSHTPSPTSPKNSPQQSHAPVLELEGKKWRVEYQEDKNDLVITNTELKQVAYIFKCNKSTLQIKGKINSITIDNCKKFGLVFDNVVGIVEVINSRDIQIQVMGKVPTISINKTEGCHIYLSEESLDCEIVSAKSSEMNILIPQDGDYKEFPVPEQFKTAWDGSKLVTEPAEIVG", "length": 480 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RUJ0-1", "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "CAP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEMQGLMERLERAVGRLELLSAGSHQPPGDCGGINGVNGGVAPSVEAFDKLMNGMVAEFLKKSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENDVAALLKPISEKIQEIQTFRERNRGSKMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTASALSVLSLGPGLPPPPPPPPPPGPPPLFESEGRREEPSPSRSALFAQLNQGEAITRGLRHVTDDQKTYKNPSLRAPGGQTPSPTKSHSPGPKSPHSHPPKKHAPMLELEGKKWRIEYQEDRNDLVISETELRQVAYIFKCNKSTLQIKGKINSIIVDNCKKFGLVFDNAVGIVEVINSKDIQMQVMGKVPTISINKTEGCHIYLSEDALDCDIVSAKSSEMNILIPRDGDYREFPVPEQFKTAWDGSKLVTEPTEIMVSERPPKPLN", "length": 486 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P40123-1", "protein_name": "Adenylyl cyclase-associated protein 2", "gene_name": "CAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA", "length": 477 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P52481-1", "protein_name": "Adenylyl cyclase-associated protein 2", "gene_name": "Cap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADMLGLMQRLEFAVSRLERLSSGLHEPPGGCGEVNSLSRGIVAPSVEAFDKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQHQQPQENEVAVLLKPISEKIQEIQTFRERNRGSDMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDLRHVDWVRSYLKIWSELQAYIKEHHTTGLTWSKTGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEGGKEEPSPSRSALFAQLNQGEAITKGLRHVTDDKKIYKNPSLRAQGQIRSPTKTRTPSPTSSKSNSPQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITVDNCKKFGLVFDHVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHLYLSKDALDCEIVSAKSSEMNVLVPQGDDYREFPIPEQFKTIWDGSKLITEPAEIMA", "length": 477 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9CYT6-1", "protein_name": "Adenylyl cyclase-associated protein 2", "gene_name": "Cap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTDMAGLMERLERAVIRLEQLSAGLDGPPRGCGEVNGVNGGVAPSVEAFDKLINSMVAEFLKNSRVLAGDVETHAEMVHGAFQAQRAFLLMVSQYQQPQENEVAVLLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIAALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVRSYLNIWSELQAYIREHHTTGLTWSKTGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEDKKEEPSPSRSALFAQLNQGEAITKGLRHVTDDKKTYKNPSLRAQGQIRSPTKTHTPSPTSPKSNSPQKHTPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITVDNCKKFGLVFDHVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHLYLSEDALDCEIVSAKSSEMNVLVPQDDDYREFPIPEQFKTIWDGSKLVTEPAEIMA", "length": 476 }, "evidence": [ { "id": "A0AAA9T3I1", "url": "https://omabrowser.org/oma/group/A0AAA9T3I1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "adenylate cyclase binding", "id": "GO:0008179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "presynaptic actin cytoskeleton organization", "id": "GO:0099140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099140", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" }, { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3I1" }, { "id": "PS51329", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51329" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-CAP/cofactor C-like", "eco_id": "ECO_0000259", "start_pos": 317, "end_pos": 455, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4S2-1", "uniprot_ac": "A0AAA9T4S2", "uniprot_id": "A0AAA9T4S2_BOVIN", "mass": { "chemical_mass": 338832.0, "monoisotopic_mass": 338832.0 }, "refseq": {}, "gene_names": [ { "name": "FRY", "type": "recommended", "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ] } ], "protein_names": [ { "name": "FRY microtubule binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FRY", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2", "locus": { "chromosome": "12", "start_pos": 28747721, "end_pos": 29077105, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006771", "url": "https://www.ensembl.org/id/ENSBTAG00000006771" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006771", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006771", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507622", "url": "https://www.ncbi.nlm.nih.gov/gene/507622", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025614", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025614", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MYQ7", "url": "https://www.orthodb.org/?gene=F1MYQ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12295", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12295", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12295:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12295:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14222", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14222", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14228", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14228", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZK3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYQ7", "url": "https://www.uniprot.org/uniprotkb/F1MYQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYQ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MYQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQQDSGFFEISIKYLLKSWSNTSPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEELQGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3016, "header": "tr|A0AAA9T4S2-1|A0AAA9T4S2_BOVIN Isoform 1 of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#A0AAA9RZK3-1", "sequence": { "sequence": "MVSYGGHPWLESLLCEDQLASPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 2846, "header": "tr|A0AAA9RZK3-1|A0AAA9T4S2_BOVIN Computationally mapped isoform of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 29013591, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120210.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120210.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078086.1" } ] } }, { "isoform_ac": "A0AAA9SF41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#A0AAA9SF41-1", "sequence": { "sequence": "MRTPESGVETEAAAPGTKNKLNSSQNDYKSRRSSLPPELLIGNDIKARLQRNFRNLEPIHLRRPKKRPSIFPASPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3062, "header": "tr|A0AAA9SF41-1|A0AAA9T4S2_BOVIN Computationally mapped isoform of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 29076067, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113534.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113534.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082225.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082225.1" } ] } }, { "isoform_ac": "A0AAA9SHJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#A0AAA9SHJ1-1", "sequence": { "sequence": "MNAKSGRQRKQAWDRSSRNLVNAAFSQTTKPVGHVSCEPGGIPAETSGSFPLAEWRVPSVVGHSSLVRPLTSPCQTADLSQKPSSRTKNKLNSSQNDYKSRRSSLPPELLIGNDIKARLQRNFRNLEPIHLRRPKKRPSIFPASPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3132, "header": "tr|A0AAA9SHJ1-1|A0AAA9T4S2_BOVIN Computationally mapped isoform of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 29076906, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100144.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100144.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085668.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085668.1" } ] } }, { "isoform_ac": "A0AAA9T4S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#A0AAA9T4S2-1", "sequence": { "sequence": "MASQQDSGFFEISIKYLLKSWSNTSPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEELQGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3016, "header": "tr|A0AAA9T4S2-1|A0AAA9T4S2_BOVIN Isoform 1 of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 28997274, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123312.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123312.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090726.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090726.1" } ] } }, { "isoform_ac": "A0AAA9THL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#A0AAA9THL7-1", "sequence": { "sequence": "MVSYGGHPWLESLLCEDQLASPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQMESLAQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3015, "header": "tr|A0AAA9THL7-1|A0AAA9THL7_BOVIN Computationally mapped isoform of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=1 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 29013591, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089102.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089102.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097745.1" } ] } }, { "isoform_ac": "F1MYQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2/entry#F1MYQ7-1", "sequence": { "sequence": "MEITTACWRRSSVISFIKGLASPVGNGYIKPPVPPVSGTQKEKGPPTMLPISVDPDSKPGEYVLKSLFVNFTTQAERKIRIIMAEPLEKPLTKSLQRGEDPQFDQVISSMSSLSEYCLPSILRTLFDWYKRQNGIEDESHEYRPRTSNKSKSDEQQRDYLMERRDLAIDFIFSLVLIEVLKQIPLHPVIDSLIHDVINLAFKHFKYKEGYLGPNTGNMHIVADLYAEVIGVLAQAKFPAVKKKFMAELKELRHKEQSPYIVQSIISLIMGMKFFRIKMYPVEDFEASLQFMQECAHYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLRNFVESLYDTTLELSSRKKHSLALYPLVTCLLCVSQKQLFLNRWHVFLNNCLSNLKNKDPKMARVALESLYRLLWVYMIRIKCESNTATQSRLITIITTLFPKGSRGVVPRDMPLNIFVKIIQFIAQERLDFAMKEIIFDFLCVGKPAKAFSLNPERMNIGLRAFLVIADSLQQKDGEPPMPVTGAVLPSGNTLRVKKTYLSKTLTEEEAKMIGMSLYYSQVRKAVDNILRHLDKEVGRCMMLTNVQMLNKEPEDMITGERKPKIDLFRTCVAAIPRLLPDGMSKLELIDLLARLSIHMDDELRHIAQNSLQGLLVDFSDWREDVLFGFTNFLLREVNDMHHTLLDSSLKLLLQLLTQWKLVIQTQGKVYEQANKIRNAELIANGSSHRIQSERGPHCSVLHAVEGFALVLLCSFQVATRKLSVLILKEIRALFVALGQPEDDDRPMIDVMDQLSSSILESFIHVAVSDSATLPLTHSVDLQWLVEWNAVLVNSHYDVKSPSHVWIFAQSVKDPWVLCLFSFLRQENLPKHCPTALSYAWPYAFTRLQSVMPLVDPNSPINAKKTSTAGSGDNYVMLWRNYLILCFGVAKPSIMSPGHLRASTPEIMATTPDGTVSYDNKAIGTPSVGVLLKQLVPLMRLEGIEITESLVLGFGRTNSLVFRELVEELHPLMKEALERRPENKKRRERRDLLRLQLLRIFELLADAGVISDSTNGALERDTLALGALFLEYVDLTRMLLEAENDKEVEILKDIRAHFSAMVANLIQRVPVHHRRFLFPQQSLRHHLFILFSQWAGPFSIMFTPLDRYSDRNHQITRYQYCALKAMSAVLCCGPVFDNVGLSPDGYLYKWLDNILACQDLRVHQLGCEVVVLLLELNPDQINLFNWAIDRCYTGSYQLASGCFKAIATVCGSRNYPFDIVTLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYSVSLAFLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNIELVDSRLLLPGSSPSSPEDEAKDREGDVTASQGLKGSGWGSPEATSLVLNNLMYMTAKYGDEVPGPEMENAWNALANNEKWSNNLRITLQFLISLCGVSSDTLLLPYIKKVAIYLCRNNTIQTMEELLFELQQTEPVNPIVQHCDNPPFYRFTASSKASAAASGTTSSSNTVVAGQDSFPDAEESKILKESDERFSNVIRAHTRLESRYSNSSGGSYDEDKNDPISPYTGWLLTITETKQPQPLPMPCTGGCWAPLVDYLPETITPRGPLHRCNVAVIFMTEMVVDHSVREDWALHLPLLLHAVFLGLDHYRPEVFEHSKKLLLHLLIALSCNSNFHAIASVLLQTREMGEAKTLTVQPAYQPEYLYTGGFDFLREDQSSPVPDSGLSSSSTSSSISLGGSSGNLPQMTQEVEDADAAADSDEKANKLIEFLTTRAFGPLWCHEDITPKNQNSKSAEQLTNFLRHVVSVFRDSKSGFHLEQHLSEVALQTALASSSRHYAGRSFQIFRALKQPLSAHALSDLLSRLVEVIGEHGDEIQGYVMEALLTLEAAVDNLSDCLKNTDLLTVLSRSSSPDLSSNTKLTASRKSTGQLNVNPGAASGNTATAERSRHQRSFSVPKKFGVVDRSSDPPRSATLDRIQACTQQGLSSKTRSSSSLKDSLTDPSHINHPTNLLATIFWVTVALMESDFEFEYLMALRLLNRLLAHMPLDKAENREKLEKLQAQLKWADFSGLQQLLLKGFTSLTTTDLTLQLFSLLTPVSRVSMVDSSQAIGFPLNVLCLLPQLIQHFENPNQFCKDVAERIAQVCLEEKNPKLSNLAHVMTLYKTHSYTRDCATWVNVVCRYLHEAYADVTLNMVTYLAELLEKGLPSMQQPLLQVIHSLLSYMDLSVVPVKQFNVEVLKTIEKYVQSIHWREALNILKLVVSRSASLVLPSYQHSDLSKIEIHRVWTSSSKELPGKTLDFHFDISETPIIGRRYDELQNSSGRDGKPRAMAVTRSASSTSSGSNSNVLVPVSWKRPQYSQKRTKEKLVHVLSLCGQEVGLSKNPSVIFSSCGDLDLLEHQTSLVSSEDGAREQENMDDTNSEQQFRVFRDFDFLDVELEDGEGESMDNFNWGVRRRSLDSLDKCDLQLLEERQLSGSSPSLNKMNHEDSDESSEEEDLTTSQILEHSDLIMNLSPSEETNPMESLTTACDLTPADPHSFNTRMASFDAALPDMNNLHISEGSKADAVQEEEDATVQEDDLSSSINELPATFECSDSFSLDTTDAEEKGNRALDHFTLASFGEGERGVSPPPSPFFSAILAAFQPTACDDAEEAWRSHINQLMCDSDGSCAVYTFHVFSSLFKNIQKRFCFLTCDAASYLGDNLRGIGSKFVSSSQMLTSCSECPTLFVDAETLLSCGLLDKLKFSVLELQEYLDTYNNRKEATLSWLANCKATFAGGSRDGVITCQPGDSEEKQLELCQRLYKLHFQLLLLFQSYCKLIGQVHEVSSTPELLNMSRELSDLKKNLKEATAAIAADPLYVEGVWSEPTFTSTEAAIQSMLECLKNNELGKALRQIRECRSLWPNDIFGSSSDDEVQTLLNIYFRHQTLGQTGTYALVGSNQSLTEICTKLMELNMEIRDMIRRAQSYRVLTAFLPDSSVSGTSL", "length": 3010, "header": "tr|F1MYQ7-1|A0AAA9T4S2_BOVIN Computationally mapped isoform of FRY microtubule binding protein OS=Bos taurus OX=9913 GN=FRY PE=4 SV=4 CANONICAL=A0AAA9T4S2-1" }, "locus": { "chromosome": "12", "start_pos": 28964817, "end_pos": 28748928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035734.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035734.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035604.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035604.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell morphogenesis", "id": "GO:0000902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" }, { "name": "negative regulation of tubulin deacetylation", "id": "GO:1904428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904428", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" }, { "name": "site of polarized growth", "id": "GO:0030427", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030427", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1485, "end_pos": 1487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1578, "end_pos": 1580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1921, "end_pos": 1923, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2349, "end_pos": 2351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2545, "end_pos": 2547, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2866, "end_pos": 2868, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2972, "end_pos": 2974, "annotation": "n_glycosylation_sequon" }, { "start_pos": 721, "end_pos": 723, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" }, { "id": "PF14228", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14228" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cell morphogenesis central region", "eco_id": "ECO_0000259", "start_pos": 1209, "end_pos": 1369, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" }, { "id": "PF14225", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cell morphogenesis protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 2042, "end_pos": 2294, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" }, { "id": "PF14222", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cell morphogenesis protein N-terminal", "eco_id": "ECO_0000259", "start_pos": 165, "end_pos": 697, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S2" }, { "id": "PF19421", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19421" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein furry C-terminal", "eco_id": "ECO_0000259", "start_pos": 2319, "end_pos": 3016, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1485, "end_pos": 1487 }, { "start_pos": 151, "end_pos": 153 }, { "start_pos": 1578, "end_pos": 1580 }, { "start_pos": 1921, "end_pos": 1923 }, { "start_pos": 2349, "end_pos": 2351 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 2545, "end_pos": 2547 }, { "start_pos": 2866, "end_pos": 2868 }, { "start_pos": 2972, "end_pos": 2974 }, { "start_pos": 721, "end_pos": 723 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1L7-1", "uniprot_ac": "A0AAA9T1L7", "uniprot_id": "A0AAA9T1L7_BOVIN", "mass": { "chemical_mass": 85580.0, "monoisotopic_mass": 85580.0 }, "refseq": {}, "gene_names": [ { "name": "SLC6A16", "type": "recommended", "evidence": [ { "id": "A0AAA9T1L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ] } ], "protein_names": [ { "name": "Solute carrier family 6 member 16", "type": "synonym", "evidence": [ { "id": "A0AAA9T1L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC6A16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7", "locus": { "chromosome": "18", "start_pos": 55770379, "end_pos": 55813238, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030543", "url": "https://www.ensembl.org/id/ENSBTAG00000030543" } ] } } ], "crossref": [ { "id": "A0AAA9T1L7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030543", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030543", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785362", "url": "https://www.ncbi.nlm.nih.gov/gene/785362", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785362", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785362", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YEKVQMT", "url": "https://omabrowser.org/oma/group/YEKVQMT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFB9", "url": "https://www.orthodb.org/?gene=F1MFB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616:SF327", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616:SF327", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFB9", "url": "https://www.uniprot.org/uniprotkb/F1MFB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSTHKIKSSLAKVGAAPESLPEITTDAQASGTSLAKVSSAESSPGSHALEDKGTATWSLTAWVSEVQAFEARAVRAQAWETQAFEAQSRASHPKATPVTEAEAAPVLKQRLLPEKVQVPEKEKSEVLITRPFWSNKAEYLLAQMGYTMRPASLWSFCYLWLHSGGGIFLIIYIFLLFLIGIPLLFLEMAAGQRMRQGNIGVWKVISPWIGGVGYTSFMVCFINGLFLNVVTAWILFYLSQSFQYPVPWEKCPLLENASGFDPECARTTPTLYFWYRMTLKASDSIEDDGPPVFSLCLPLFLSVCLLGVFMLNGLKWTGKVMCVLVSSSGLIMLCFVVRSIMLEGAVFGLHYMTIVKISAIYNVNVWRGAGNQVLCSLGLGFGSIISIASHIQSSSSCLNDAVIVALANLISMMLVTPFIFSVLGFWATQLTHRCNEKNTETLLNLVNMGILPPEAQPPQNLIGNPTSIFTSWFNSLSNPIKKEVLSHVPECNLEEQFLKIKESTNFAFLAFVEAMSFIPGSVFWSFLFFLMLLNLEMSTMIGIMDSIITSLQDIFISVQKYTKLFTVVVLMIMFLCGLFFTRPSGSYYIRLLTDYWTILPIIIVIIFENLAVKWAREASSFFADMANLWGHPMYSIIRWLWSYLIPVVLLALSVTTVFQLSLKNITYLAWDSSTSKEIVRQYPSWGLFTLFALLLIVILPIPIYFVYCFTHGIPFNSTSWDKPVISSKSLPLSFQLTPIKEVENEEILQGDIEISISNCNCLCL", "length": 765, "header": "tr|A0AAA9T1L7-1|A0AAA9T1L7_BOVIN Isoform 1 of Solute carrier family 6 member 16 OS=Bos taurus OX=9913 GN=SLC6A16 PE=4 SV=1 CANONICAL=A0AAA9T1L7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7/entry#A0AAA9RZR7-1", "sequence": { "sequence": "ITTDAQASGTSLAKVSSAESSPGSHALEDKGTATWSLTAWVSEVQAFEARAVRAQARASHPKATPVTEAEAAPVLKQRLLPEKVQVPEKEKSEVLITRPFWSNKAEYLLAQMGYTMRPASLWSFCYLWLHSGGGIFLIIYIFLLFLIGIPLLFLEMAAGQRMRQGNIGVWKVISPWIGGVGYTSFMVCFINGLFLNVVTAWILFYLSQSFQYPVPWEKCPLLENASGFDPECARTTPTLYFWYRMTLKASDSIEDDGPPVFSLCLPLFLSVCLLGVFMLNGLKWTGKVMCVLVSSSGLIMLCFVVRSIMLEGAVFGLHYMTIVKISAIYNVNVWRGAGNQVLCSLGLGFGSIISIASHIQSSSSCLNDAVIVALANLISMMLVTPFIFSVLGFWATQLTHRCNEKNTETLLNLVNMGILPPEAQPPQNLIGNPTSIFTSWFNSLSNPIKKEVLSHVPECNLEEQFLKIKESTNFAFLAFVEAMSFIPGSVFWSFLFFLMLLNLEMSTMIGIMDSIITSLQDIFISVQKYTKLFTVVVLMIMFLCGLFFTRPSGSYYIRLLTDYWTILPIIIVIIFENLAVKWAREASSFFADMANLWGHPMYSIIRWLWSYLIPVVLLALSVTTVFQLSLKNITYLAWDSSTVSHPPQTPDLHREWGARFFNPLLV", "length": 666, "header": "tr|A0AAA9RZR7-1|A0AAA9T1L7_BOVIN Computationally mapped isoform of Solute carrier family 6 member 16 OS=Bos taurus OX=9913 GN=SLC6A16 PE=4 SV=1 CANONICAL=A0AAA9T1L7-1" }, "locus": { "chromosome": "18", "start_pos": 55796393, "end_pos": 55771118, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079094.1" } ] } }, { "isoform_ac": "A0AAA9T1L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7/entry#A0AAA9T1L7-1", "sequence": { "sequence": "MRSTHKIKSSLAKVGAAPESLPEITTDAQASGTSLAKVSSAESSPGSHALEDKGTATWSLTAWVSEVQAFEARAVRAQAWETQAFEAQSRASHPKATPVTEAEAAPVLKQRLLPEKVQVPEKEKSEVLITRPFWSNKAEYLLAQMGYTMRPASLWSFCYLWLHSGGGIFLIIYIFLLFLIGIPLLFLEMAAGQRMRQGNIGVWKVISPWIGGVGYTSFMVCFINGLFLNVVTAWILFYLSQSFQYPVPWEKCPLLENASGFDPECARTTPTLYFWYRMTLKASDSIEDDGPPVFSLCLPLFLSVCLLGVFMLNGLKWTGKVMCVLVSSSGLIMLCFVVRSIMLEGAVFGLHYMTIVKISAIYNVNVWRGAGNQVLCSLGLGFGSIISIASHIQSSSSCLNDAVIVALANLISMMLVTPFIFSVLGFWATQLTHRCNEKNTETLLNLVNMGILPPEAQPPQNLIGNPTSIFTSWFNSLSNPIKKEVLSHVPECNLEEQFLKIKESTNFAFLAFVEAMSFIPGSVFWSFLFFLMLLNLEMSTMIGIMDSIITSLQDIFISVQKYTKLFTVVVLMIMFLCGLFFTRPSGSYYIRLLTDYWTILPIIIVIIFENLAVKWAREASSFFADMANLWGHPMYSIIRWLWSYLIPVVLLALSVTTVFQLSLKNITYLAWDSSTSKEIVRQYPSWGLFTLFALLLIVILPIPIYFVYCFTHGIPFNSTSWDKPVISSKSLPLSFQLTPIKEVENEEILQGDIEISISNCNCLCL", "length": 765, "header": "tr|A0AAA9T1L7-1|A0AAA9T1L7_BOVIN Isoform 1 of Solute carrier family 6 member 16 OS=Bos taurus OX=9913 GN=SLC6A16 PE=4 SV=1 CANONICAL=A0AAA9T1L7-1" }, "locus": { "chromosome": "18", "start_pos": 55797839, "end_pos": 55770627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089555.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089555.1" } ] } }, { "isoform_ac": "F1MFB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7/entry#F1MFB9-1", "sequence": { "sequence": "MRSTHKIKSSLAKVGAAPESLPEITTDAQASGTSLAKVSSAESSPGSHALEDKGTATWSLTAWVSEVQAFEARAVRAQAWETQAFEAQSRASHPKATPVTEAEAAPVLKQRLLPEKVQVPEKEKSEVLITRPFWSNKAEYLLAQMGYTMRPASLWSFCYLWLHSGGGIFLIIYIFLLFLIGIPLLFLEMAAGQRMRQGNIGVWKVISPWIGGVGYTSFMVCFINGLFLNVVTAWILFYLSQSFQYPVPWEKCPLLENASGFDPECARTTPTLYFWYRMTLKASDSIEDDGPPVFSLCLPLFLSVCLLGVFMLNGLKWTGKVMCVLVSSSGLIMLCFVVRSIMLEGAVFGLHYMTIVKISAIYNVNVWRGAGNQVLCSLGLGFGSIISIASHIQSSSSCLNDAVIVALANLISMMLVTPFIFSVLGFWATQLTHRCNEKNTETLLNLVNMGILPPEAQPPQNLIGNPTSIFTSWFNSLSNPIKKEVLSHVPECNLEEQFLKIKESTNFAFLAFVEAMSFIPGSVFWSFLFFLMLLNLEMSTMIGIMDSIITSLQDIFISVQKYTKLFTVVVLMIMFLCGLFFTRPSGSYYIRLLTDYWTILPIIIVIIFENLAVKWAREASSFFADMANLWGHPMYSIIRWLWSYLIPVVLLALSVTTVFQLSLKNITYLAWDSSTSKEIVRQYPSWGLFTLFALLLIVILPIPIYFVYCFTHGIPFNSTSWDKPVISSKSLPLSFQLTPIKEVENEEILQGDIEIADQPVV", "length": 761, "header": "tr|F1MFB9-1|A0AAA9T1L7_BOVIN Computationally mapped isoform of Solute carrier family 6 member 16 OS=Bos taurus OX=9913 GN=SLC6A16 PE=4 SV=3 CANONICAL=A0AAA9T1L7-1" }, "locus": { "chromosome": "18", "start_pos": 55797839, "end_pos": 55770722, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017256.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017256.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017256.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017256.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785362", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785362", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1SR47-1", "protein_name": "Solute carrier family 6, member 16", "gene_name": "Slc6a16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRSTKEGENEPSKSRASPSDVPQASESNMEESVSWDSKLTDMDSHLGAWEVGMLTWSPSTWIAQAQVSETRMAKAQAWETLALARITLQPKPSVTELATVTTLEQESSELVNRMSRESSEGYPPRQLWASKVEYMLAIMSYLLMPSGVLRFASGWVHKGSCSFFIAYILMLLGIGIPLLFLEMAVGQRAQQSSADMWKNLSPWFGGVGYSMVMVCFITNTYLNVFNSWILFYMSHIFYFVVPWDQCPLQRNSSNFDPECEQATSYTYFWYRKTLKASDRIEDGGQPSFSLGMSLFLSFCLICAFLVNGIKSIGKVLFVLLLVPYSIIVCFLIRTLSMDGAEYGLKHLLILKVASISDLTIWCHAGIQVLFDIGLGFGPIVSLASHVPDFNNCMADAFLMALFKIITLLMTTPFLLSILGFWATTTTHHCCKKNQETLLRLVAQGILPPDAQPPDLSGNPTSNYNSWLSSLPPPLRSAVLSVVPECSVQKQFLKIKDNPRFLFLIFTEVISLLPGSGFWIVLFFLLLLTLGLCSNLMFMLGNVLTLQDTFPFCRRQPRLLIVCVSMAMFLCGLIFIQPSGIYYFSLLSECWVAVPVIIIIICENLAVAWAYGADRFLADMVALLGRPIFSGCGWLWCYISPMVVLGLLTSVFVYLVKGPLVYFAWDSSTSKEVVRVFPEWSKILIAGLTVFVLMPIPAYFVYCLTLGIPFRSTPSSKLPLGSGQLQSTKEASKDILQDYKTES", "length": 742 }, "evidence": [ { "id": "A0AAA9T1L7", "url": "https://omabrowser.org/oma/group/A0AAA9T1L7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M3H9-1", "protein_name": "Solute carrier family 6, member 16", "gene_name": "Slc6a16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSSKESEDAFFLAKSRASASDRPEESSLVKTSGSSLDKNVSIETTKLSEMDSNLLVWEDGTLATWSTSAWIAQAQVSESRVAKAQAWETLALEAQARGALQFNKPSTTEYSMETTPKQESPIELNKTSKENSNVFPPWLLWSSKAEYILALMGYLVMPSGLLRFVTCWVHKGSWSFFIAYLLMLFGLGIPLLFLEMAVGQRAQQSSIDLWKTLSPWFGGLGYSMVMVCLITNTYLNVFNSWILFYMSHIFHFVVPWDRCPLQKNSSDFDPECEQATSYTYFWYRQTLKASDSIEDGGQPSFNLAMFLFLAWCLICVFMVNGIKSLGKVLCVLLQVPYFIIICFLVRTLSMGNGIGYGLNYLLILEVARISDLTMWCQAGIQVLFDIGLGFGPVISLSSHMSDFNNCLKDAFLMGLFKIVTLLITTPFFLSILGFWATITTHHCCKKNTNKLLMLIAQGILPPEVEPPDLNDDPISIYNSWLNSLPPPLRSAVLSMVPECNIQKQFMRIEDSPRFLFLIFTEVISLLPGSAFWTVLFFLALLGLGLCTNLMYMLGNILTLQDTFPFCRRQPRLLTVGVSMTTFLCGLIFIQPSGIYYFSLLSEYWVAVPIITIILCETLAVAWAYGAKRFLADMMALLSRPIFPGCSWLWRYVSPVVLLGLLLFICIYLVQGPLVYMAWDSSTSKEVVRYFPMWSLMLIAGLSAVVLMPIPAYFAYCLNLGIPFRSAPSCKLPLGSGQLLTTKEASKDILQGYKPES", "length": 757 }, "evidence": [ { "id": "A0AAA9T1L7", "url": "https://omabrowser.org/oma/group/A0AAA9T1L7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9GZN6-1", "protein_name": "Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5", "gene_name": "SLC6A16", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTEAQPSTSLLANTSWTGTVISDSVPGSQTWEDKGSLTRSATSWTSEAQVSAARVAEAQARTSQPKQISVLEALTASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLNSGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFILGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMNSSGFDPECERTTPSIYFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFIIVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYMPQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGFWATVITHRCCERNAEILLKLINLGKLPPDAKPPVNLLYNPTSIYNAWLSGLPQHIKSMVLREVTECNIETQFLKASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSFFRKHTKLLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIVFPIIVVVVFETMAVSWAYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSSTSKEVLRPYPPWALLLMITLFAIVILPIPAYFVYCRIHRIPFRPKSGDGPMTASTSLPLSHQLTPSKEVQKEEILQVDETKYPSTCNVTS", "length": 736 }, "evidence": [ { "id": "A0AAA9T1L7", "url": "https://omabrowser.org/oma/group/A0AAA9T1L7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 665, "end_pos": 667, "annotation": "n_glycosylation_sequon" }, { "start_pos": 717, "end_pos": 719, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 665, "end_pos": 667 }, { "start_pos": 717, "end_pos": 719 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4A8-1", "uniprot_ac": "A0AAA9T4A8", "uniprot_id": "A0AAA9T4A8_BOVIN", "mass": { "chemical_mass": 71125.0, "monoisotopic_mass": 71125.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC148", "type": "recommended", "evidence": [ { "id": "A0AAA9T4A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 148", "type": "synonym", "evidence": [ { "id": "A0AAA9T4A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8/entry#names_and_taxonomy" } ] } ], 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"614176", "url": "https://www.ncbi.nlm.nih.gov/gene/614176", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614176", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MSD5", "url": "https://www.orthodb.org/?gene=F1MSD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21549", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21549", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21549:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21549:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27813", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27813", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RZV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSD5", "url": "https://www.uniprot.org/uniprotkb/F1MSD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSD5-1", "url": "https://www.uniprot.org/uniprotkb/F1MSD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TCAPSASPDNLIFHMKNEIRSTKYKPVDYQQLHALTEAKKLASASTELKIRKTVQTSKLSKEQTLIKQHKQVWWQEHQRLNEVRYKMESEIKSLFSEENIGNECLSDLMNFEQELSEQWCTYLKNVINPIQQLREDLKYRQHHISQYSHSHSESNSMKVLEEVDFVKKQLKAVYEQLRLEQQEIENYLSDWSMKILDHSSEERSNLLSQLPMELETLECPYPDLKSSILNEFYNFTEKYQKKLQDFDLQLEDIYRNFQLSDEDHWIYQAVLDQYPGDLCGRRTLYLDMLQRCLPHKSRHDLVEHEKYCNQYRFAKEQRRILILSWNKNRRDFIQKAVLTLAEACATHEMESMLAKDRKKQQEVCADLKAKVLQWRARQEEITRLEMEISARRREKEEEKEKLWKKKELLQREEKKKEIRKYRADKEQKWQEMEMRGLRRLEELKKLMAEQSVKDRERVKYRQELLEKRLMEKKEVALQEALEEEEREKRLEALRKQVAIVAQFDPVRMMSDTVASKARMGIGTEEEFILQKPLFTLNTYNEQQIISDPRLRFELALREAGLHKTFYAKEILPKISPQKPPRKDMESTVFKI", "length": 591, "header": "tr|A0AAA9T4A8-1|A0AAA9T4A8_BOVIN Isoform 1 of Coiled-coil domain containing 148 OS=Bos taurus OX=9913 GN=CCDC148 PE=4 SV=1 CANONICAL=A0AAA9T4A8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8/entry#A0AAA9RZV5-1", "sequence": { "sequence": "MSSKGAVLLKRSSMENMNKRDQLFMTIQKNDSSDNLIFHMKNEIRSTKYKPVDYQQLHALTEAKKLASASTELKIRKTVQTSKLSKEQTLIKQHKQVWWQEHQRLNEVRYKMESEIKSLFSEENIGNECLSDLMNFEQELSEQWCTYLKNVINPIQQLREDLKYRQHHISQYSHSHSESNSMKVLEEVDFVKKQLKAVYEQLRLEQQEIENYLSDWSMKILDHSSEERSNLLSQLPMELETLECPYPDLKSSILNEFYNFTEKYQKKLQDFDLQLEDIYRNFQLSDEDHWIYQAVLDQYPGDLCGRRTLYLDMLQRCLPHKSRHDLVEHEKYCNQYRFAKEQRRILILSWNKNRRDFIQKAVLTLAEACATHEMESMLAKDRKKQQEVCADLKAKVLQWRARQEEITRLEMEISARRREKEEEKEKLWKKKELLQREEKKKEIRKYRADKEQKWQEMEMRGLRRLEELKKLMAEQSVKDRERVKYRQELLEKRLMEKKEVALQEALEEEEREKRLEALRKQVAIVAQFDPVRMMSDTVASKARMGIGTEEEFILQKPLFTLNTYNEQQIISDPRLRFELALREAGLHKTFYAKEILPKISPQKPPRKDMESTVFKI", "length": 616, "header": "tr|A0AAA9RZV5-1|A0AAA9T4A8_BOVIN Computationally mapped isoform of Coiled-coil domain containing 148 OS=Bos taurus OX=9913 GN=CCDC148 PE=4 SV=1 CANONICAL=A0AAA9T4A8-1" }, "locus": { "chromosome": "2", "start_pos": 38200514, "end_pos": 37990059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125610.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125610.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075348.1" } ] } }, { "isoform_ac": "A0AAA9T4A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8/entry#A0AAA9T4A8-1", "sequence": { "sequence": "TCAPSASPDNLIFHMKNEIRSTKYKPVDYQQLHALTEAKKLASASTELKIRKTVQTSKLSKEQTLIKQHKQVWWQEHQRLNEVRYKMESEIKSLFSEENIGNECLSDLMNFEQELSEQWCTYLKNVINPIQQLREDLKYRQHHISQYSHSHSESNSMKVLEEVDFVKKQLKAVYEQLRLEQQEIENYLSDWSMKILDHSSEERSNLLSQLPMELETLECPYPDLKSSILNEFYNFTEKYQKKLQDFDLQLEDIYRNFQLSDEDHWIYQAVLDQYPGDLCGRRTLYLDMLQRCLPHKSRHDLVEHEKYCNQYRFAKEQRRILILSWNKNRRDFIQKAVLTLAEACATHEMESMLAKDRKKQQEVCADLKAKVLQWRARQEEITRLEMEISARRREKEEEKEKLWKKKELLQREEKKKEIRKYRADKEQKWQEMEMRGLRRLEELKKLMAEQSVKDRERVKYRQELLEKRLMEKKEVALQEALEEEEREKRLEALRKQVAIVAQFDPVRMMSDTVASKARMGIGTEEEFILQKPLFTLNTYNEQQIISDPRLRFELALREAGLHKTFYAKEILPKISPQKPPRKDMESTVFKI", "length": 591, "header": "tr|A0AAA9T4A8-1|A0AAA9T4A8_BOVIN Isoform 1 of Coiled-coil domain containing 148 OS=Bos taurus OX=9913 GN=CCDC148 PE=4 SV=1 CANONICAL=A0AAA9T4A8-1" }, "locus": { "chromosome": "2", "start_pos": 38200514, "end_pos": 37903126, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098112.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098112.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092629.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092629.1" } ] } }, { "isoform_ac": "A0AAA9TLQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8/entry#A0AAA9TLQ2-1", "sequence": { "sequence": "MATHSSILAWRIPWTEESGGLQAMAGCKESDVAEWLTLSLTFRYKMESEIKSLFSEENIGNECLSDLMNFEQELSEQWCTYLKNVINPIQQLREDLKYRQHHISQYSHSHSESNSMKVLEEVDFVKKQLKAVYEQLRLEQQEIENYLSDWSMKILDHSSEERSNLLSQLPMELETLECPYPDLKSSILNEFYNFTEKYQKKLQDFDLQLEDIYRNFQLSDEDHWIYQAVLDQYPGDLCGRRTLYLDMLQRCLPHKSRHDLVEHEKYCNQYRFAKEQRRILILSWNKNRRDFIQKAVLTLAEACATHEMESMLAKDRKKQQEVCADLKAKVLQWRARQEEITRLEMEISARRREKEEEKEKLWKKKELLQREEKKKEIRKYRADKEQKWQEMEMRGLRRLEELKKLMAEQSVKDRERVKYRQELLEKRLMEKKEVALQEALEEEEREKRLEALRKQVAIVAQFDPVRMMSDTVASKARMGIGTEEEFILQKPLFTLNTYNEQQIISDPRLRFELALREAGLHKTFYAKEILPKISPQKPPRKDMESTVFKI", "length": 550, "header": "tr|A0AAA9TLQ2-1|A0AAA9TLQ2_BOVIN Computationally mapped isoform of Coiled-coil domain containing 148 OS=Bos taurus OX=9913 GN=CCDC148 PE=4 SV=1 CANONICAL=A0AAA9T4A8-1" }, "locus": { "chromosome": "2", "start_pos": 38200514, "end_pos": 38001567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097869.1" } ] } }, { "isoform_ac": "F1MSD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A8/entry#F1MSD5-1", "sequence": { "sequence": "MIAQIRKTVQTSKLSKEQTLIKQHKQVWWQEHQRLNEVRYKMESEIKSLFSEENIGNECLSDLMNFEQELSEQWCTYLKNVINPIQQLREDLKYRQHHISQYSHSHSESNSMKVLEEVDFVKKQLKAVYEQLRLEQQEIENYLSDWSMKILDHSSEERSNLLSQLPMELETLECPYPDLKSSILNEFYNFTEKYQKKLQDFDLQLEDIYRNFQLSDEDHWIYQAVLDQYPGDLCGRRTLYLDMLQRCLPHKSRHDLVEHEKYCNQYRFAKEQRRILILSWNKNRRDFIQKAVLTLAEACATHEMESMLAKDRKKQQEVCADLKAKVLQWRARQEEITRLEMEISARRREKEEEKEKLWKKKELLQREEKKKEIRKYRADKEQKWQEMEMRGLRRLEELKKLMAEQSVKDRERVKYRQELLEKRLMEKKEVALQEALEEEEREKRLEALRKQVAIVAQFDPVRMMSDTVASKARMGIGTEEEFILQKPLFTLNTYNEQQIISDPRLRFELALREAGLHKTFYAKEILPKISPQKPPRKDMESTVFKI", "length": 546, "header": "tr|F1MSD5-1|A0AAA9T4A8_BOVIN Computationally mapped isoform of Coiled-coil domain containing 148 OS=Bos taurus OX=9913 GN=CCDC148 PE=4 SV=4 CANONICAL=A0AAA9T4A8-1" }, "locus": { "chromosome": "2", "start_pos": 38200514, "end_pos": 37990500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005591.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005591.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005591.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005591.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614176", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 234, "end_pos": 236 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2D5-1", "uniprot_ac": "A0AAA9T2D5", "uniprot_id": "A0AAA9T2D5_BOVIN", "mass": { "chemical_mass": 16841.0, "monoisotopic_mass": 16841.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "tRNA selenocysteine 1-associated protein 1 C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T2D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5", "locus": {} } ], "crossref": [ { "id": "A0AAA9T2D5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2D5", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR040434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37457", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37457", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37457:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37457:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17654", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17654", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGQESFAGLGSTQQDTYYWYWQRVKPDFPSCQPHPFSSRYEQQQGGYPPGYSSGRGAGGNGPNLYSACETSGHPSETSLPPKETTSLAENQVEDSLEDPNLHLNIEELNKEFMVKSEELYQSLMNSHWQPLDTVYSEIPDKTPQEQDAD", "length": 150, "header": "tr|A0AAA9T2D5-1|A0AAA9T2D5_BOVIN Isoform 1 of tRNA selenocysteine 1-associated protein 1 C-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T2D5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5/entry#A0AAA9S0F2-1", "sequence": { "sequence": "PPKETTSLAENQVEDSLEDPNLHLNIEELNKEFMVKSEELYQSLMNSHWQPLDTVYSEIPDKTPQEQDAD", "length": 70, "header": "tr|A0AAA9S0F2-1|A0AAA9T2D5_BOVIN Computationally mapped isoform of tRNA selenocysteine 1-associated protein 1 C-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T2D5-1" }, "locus": { "chromosome": "23", "start_pos": 45443218, "end_pos": 45441438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124088.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124088.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077116.1" } ] } }, { "isoform_ac": "A0AAA9T2D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5/entry#A0AAA9T2D5-1", "sequence": { "sequence": "MAGQESFAGLGSTQQDTYYWYWQRVKPDFPSCQPHPFSSRYEQQQGGYPPGYSSGRGAGGNGPNLYSACETSGHPSETSLPPKETTSLAENQVEDSLEDPNLHLNIEELNKEFMVKSEELYQSLMNSHWQPLDTVYSEIPDKTPQEQDAD", "length": 150, "header": "tr|A0AAA9T2D5-1|A0AAA9T2D5_BOVIN Isoform 1 of tRNA selenocysteine 1-associated protein 1 C-terminal domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T2D5-1" }, "locus": { "chromosome": "23", "start_pos": 45443218, "end_pos": 45440984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123106.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123106.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092955.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D5" }, { "id": "PF17654", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17654" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "tRNA selenocysteine 1-associated protein 1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 140, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3H0-1", "uniprot_ac": "A0AAA9T3H0", "uniprot_id": "A0AAA9T3H0_BOVIN", "mass": { "chemical_mass": 73418.0, "monoisotopic_mass": 73418.0 }, "refseq": {}, "gene_names": [ { "name": "TDP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0" } ] } ], "protein_names": [ { "name": "Tyrosyl-DNA phosphodiesterase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T3H0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR5#function" }, { "database": "UniProtKB", "id": "ARBA00054472", "url": "https://www.uniprot.org/uniprotkb/ARBA00054472#function" }, { "database": "UniProtKB", "id": "A0AAA9T7W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7W1#function" }, { "database": "UniProtKB", "id": "F1MST1", "url": "https://www.uniprot.org/uniprotkb/F1MST1#function" }, { "database": "UniProtKB", "id": "A0AAA9S122", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S122#function" }, { "database": "UniProtKB", "id": "A0AAA9S356", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S356#function" }, { "database": "UniProtKB", "id": "A0AAA9T3H0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3H0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TDP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0", "locus": { "chromosome": "10", "start_pos": 101708726, "end_pos": 101636795, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013138", "url": "https://www.ensembl.org/id/ENSBTAG00000013138" } ] } } ], "crossref": [ { "id": "A0AAA9T3H0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3H0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013138", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013138", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09193", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09193", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09195", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09195", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517053", "url": "https://www.ncbi.nlm.nih.gov/gene/517053", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MST1", "url": "https://www.orthodb.org/?gene=F1MST1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12415:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12415:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5693571", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693571", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S122", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S122", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S122-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S122-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S356", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S356", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S356-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S356-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3H0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3H0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7W1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST1", "url": "https://www.uniprot.org/uniprotkb/F1MST1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST1-1", "url": "https://www.uniprot.org/uniprotkb/F1MST1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTSANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFIPRFTAGLLHTLRNPHTTTVSSSGFFPSGQMAMSFSESSLTGYLTSPPKGLTVELIKDVVAVKQMPCVREAPGISWLLRHMRRLERRPGLRLAVRHPGHRLAVGHVRR", "length": 659, "header": "tr|A0AAA9T3H0-1|A0AAA9T3H0_BOVIN Isoform 1 of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=1 CANONICAL=A0AAA9T3H0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S122-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#A0AAA9S122-1", "sequence": { "sequence": "MMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTSANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFIDHGFGTSLMSKHLIHMGTCGFPPESRKAL", "length": 581, "header": "tr|A0AAA9S122-1|A0AAA9T3H0_BOVIN Computationally mapped isoform of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=2 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101708487, "end_pos": 101640032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134384.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134384.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077357.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077357.2" } ] } }, { "isoform_ac": "A0AAA9S356-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#A0AAA9S356-1", "sequence": { "sequence": "MLSSHLILCRPLLPEDVGVQSCKEPNILEVNRTRSMMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTSANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFSGSSQEPTASFPVPYDLPPEVYGDRDRPWIWNIPYVKAPDTHGNMWVPS", "length": 647, "header": "tr|A0AAA9S356-1|A0AAA9T3H0_BOVIN Computationally mapped isoform of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=1 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101708468, "end_pos": 101636802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134536.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134536.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076535.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076535.1" } ] } }, { "isoform_ac": "A0AAA9SSR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#A0AAA9SSR5-1", "sequence": { "sequence": "MMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTSANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFVLLLCAPRPRKPGLVPGALCCHC", "length": 574, "header": "tr|A0AAA9SSR5-1|A0AAA9T3H0_BOVIN Computationally mapped isoform of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=1 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101694584, "end_pos": 101640032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126154.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126154.2" 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Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=1 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101693267, "end_pos": 101640032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105216.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105216.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091018.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091018.1" } ] } }, { "isoform_ac": "A0AAA9T7W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#A0AAA9T7W1-1", "sequence": { "sequence": "MMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTSANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFLNIS", "length": 555, "header": "tr|A0AAA9T7W1-1|A0AAA9T7W1_BOVIN Computationally mapped isoform of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=1 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101700844, "end_pos": 101640032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092874.1" } ] } }, { "isoform_ac": "F1MST1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H0/entry#F1MST1-1", "sequence": { "sequence": "MMSQEGNYGKWTISSSDESEEEKPQPDKPSASLLPDAGQGAAGQLKYTCSEARKAAHRRKLEPMKFSSTDSVSEASPCKRQKTGSQEDLGWCLSSSEDELPQELQQEQAKDSRVKEEQGPPSPRDRTARGAGPHGPPTSCGLPEEEDEQETSGEGQDVWDLLDKGNPFQFYLTRVSGIKPKYNTGALHIKDILSPLFGTLVSSAQFNYCFDVDWLIRQYPPEFRKKPVLLVHGDKREAKAHLLAEAKPYGNVTLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIVHGTHGSGESATNFKADLISYLAAYNAAPLKEWIDTIQEHDLSETNVYLIASTPGRFQGNQKDNWGHFRLRKLLKEHASPMPKAESWPVIGQFSSIGSMGADESKWLCSEFKESLVTLGKESRTLGSAAPLHLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSADTSGRSNAMPHIKTYLRPSPDFSQIAWFLVTRIRRPEWTCLLENASACANLSKAAWGALEKSGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFSGSSQEPTASFPVPYDLPPEVYGDRDRPWIWNIPYVKAPDTHGNMWVPS", "length": 628, "header": "tr|F1MST1-1|F1MST1_BOVIN Computationally mapped isoform of Tyrosyl-DNA phosphodiesterase 1 OS=Bos taurus OX=9913 GN=TDP1 PE=3 SV=3 CANONICAL=A0AAA9T3H0-1" }, "locus": { "chromosome": "10", "start_pos": 101708468, "end_pos": 101640032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017463.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017463.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017463.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017463.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5693571", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693571", "resource": "Reactome", "description": "Nonhomologous End-Joining (NHEJ)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3H0", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9S1M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U053", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U053", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U053-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U053-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLB1", "url": "https://www.uniprot.org/uniprotkb/F1MLB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLB1-1", "url": "https://www.uniprot.org/uniprotkb/F1MLB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQQQALAGTLVAAAGSAIETDPFKRQQAGPPAGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKAAAAPFQTSQASTGAPRHQPTSTFSTAPSPAHPAKLRAQTTVPASAPGPPQPQPQAPSHPAGQSALPQGLVLTSQAQARLPSGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQLPQQAPPAQAPAGPPQPTAQVQVQPPQPTQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", "length": 3095, "header": "tr|A0AAA9T2W4-1|A0AAA9T2W4_BOVIN Isoform 1 of E1A binding protein p400 OS=Bos taurus OX=9913 GN=EP400 PE=4 SV=1 CANONICAL=A0AAA9T2W4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4/entry#A0AAA9S1M0-1", "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEQALAGTLVAAAGSAIETDPFKRQQAGPPAGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKGGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQLPQQAPPAQAPAGPPQPTAQVQVQPPQPTQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", "length": 2976, "header": "tr|A0AAA9S1M0-1|A0AAA9T2W4_BOVIN Computationally mapped isoform of E1A binding protein p400 OS=Bos taurus OX=9913 GN=EP400 PE=4 SV=1 CANONICAL=A0AAA9T2W4-1" }, "locus": { "chromosome": "17", "start_pos": 45134100, "end_pos": 45048650, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106310.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106310.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075981.1" } ] } }, { "isoform_ac": "A0AAA9T2W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4/entry#A0AAA9T2W4-1", "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQQQALAGTLVAAAGSAIETDPFKRQQAGPPAGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKAAAAPFQTSQASTGAPRHQPTSTFSTAPSPAHPAKLRAQTTVPASAPGPPQPQPQAPSHPAGQSALPQGLVLTSQAQARLPSGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQLPQQAPPAQAPAGPPQPTAQVQVQPPQPTQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", "length": 3095, "header": "tr|A0AAA9T2W4-1|A0AAA9T2W4_BOVIN Isoform 1 of E1A binding protein p400 OS=Bos taurus OX=9913 GN=EP400 PE=4 SV=1 CANONICAL=A0AAA9T2W4-1" }, "locus": { "chromosome": "17", "start_pos": 45134100, "end_pos": 45048650, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090802.1" } ] } }, { "isoform_ac": "A0AAA9T4M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4/entry#A0AAA9T4M6-1", "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQQALAGTLVAAAGSAIETDPFKRQQAGPPAEQSKRPRLEVGHQGVVFQHPGVNTGVPLQQLMPTVQGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKAAAAPFQTSQASTGAPRHQPTSTFSTAPSPAHPAKLRAQTTVPASAPGPPQPQPQAPSHPAGQSALPQGLVLTSQAQARLPSGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", "length": 3057, "header": "tr|A0AAA9T4M6-1|A0AAA9T4M6_BOVIN Computationally mapped isoform of E1A binding protein p400 OS=Bos taurus OX=9913 GN=EP400 PE=4 SV=1 CANONICAL=A0AAA9T2W4-1" }, "locus": { "chromosome": "17", "start_pos": 45134100, "end_pos": 45048650, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122275.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122275.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091648.1" } ] } }, { "isoform_ac": "A0AAA9U053-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4/entry#A0AAA9U053-1", "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQQALAGTLVAAAGSAIETDPFKRQQAGPPAEQSKRPRLEVGHQGVVFQHPGVNTGVPLQQLMPTVQGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKAAAAPFQTSQASTGAPRHQPTSTFSTAPSPAHPAKLRAQTTVPASAPGPPQPQPQAPSHPAGQSALPQGLVLTSQAQARLPSGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQLPQQAPPAQAPAGPPQPTAQVQVQPPQPTQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", "length": 3130, "header": "tr|A0AAA9U053-1|A0AAA9U053_BOVIN Computationally mapped isoform of E1A binding protein p400 OS=Bos taurus OX=9913 GN=EP400 PE=4 SV=1 CANONICAL=A0AAA9T2W4-1" }, "locus": { "chromosome": "17", "start_pos": 45134100, "end_pos": 45048650, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132339.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132339.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102958.1" } ] } }, { "isoform_ac": "F1MLB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2W4/entry#F1MLB1-1", "sequence": { "sequence": "MHHGSGPQNVQHQLQRSRAFAGSEEEQQAHPNPPQSPATPFAPAVSPSAPQSPGYQVSQLMNRSPVAGQNVNIALQNVGPVVGGNPQITLAPLPLPSPTSPGFQFSAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPAPGPGLQSVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQEGSGLAQMAPGTQVQLQHAGAPITVSRERRLSQPHAQSGGTVHHLGPQSPAAAGGAGLQPLSSPGHITTTSLPPQISSIIQGQLIQQQQVLQGPPLTRPLLPGVGVGVGGTSAFGMTSPPPPTSPSRTAVPPGLSSLPLSSAGSTGVRKAPRKLEEIPPASQELAQMRKQCLDYHYREMEALKEAFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDLEEEEEEEEEEEEEKSEVINDEQALAGTLVAAAGSAIETDPFKRQQAGPPAEQSKRPRLEVGHQGVVFQHPGVNTGVPLQQLMPTVQGGMPPAPQATQLAGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPSRLPQAGLPAAPLPPALQFPPQPQMAEPQTQLPVPVKTQPPNAPAPAPPPGPLPTAPPQPTPPTLHIPMPGKAQMQAPPLPAQPQTVAPTRPPVDPTQSCLRPPPSTSTTSTVAPASGSGLGPSPARASPVNRPSLATNKSLSPVTARAPGAAVSAPPKPQSPAQNAAPPQDSSQDKLAEQIALENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVARHHEEKKLREERGKKEEQNRLRRIAASTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRKGKELRPKGLDVLPENFLDSGISGRKRKASTSLTDDEVEDEEETIEEEEANEGVVDHQTELSNLAKEAELPLIDLMKLYEGAFLPNFQWPQPKPDSEETSEEEDMEDCPGDRESRKDVVLIDSLFIMDQFKAAERVIVGKPHTRDIAEVTAVAEAILPKGSARISTAVKLNAPALLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVIVRSCNILKWELELKRWCPGLKTLLYVGSHRELKAKRQEWTEPNSFNICITSYKQFFKGFASFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDAPLHNTFLELWTMVHFLIPGISRPYLHFPLKAPNEENQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVDVLSILLRLQRICNHPGLVAPRLPESSYTAGPLQYRSASLVLKALDRDFWKETDLSIFDLLGLENKMTRHEAELLGKKKVTRKLFEELFTAPPPSSRPAAVRLKPSRLFQAVQYGQKPEGRTVAFPNTHPPRTATPATATATPQGHVRGRPPIATFSANPDAKAAAAPFQTSQASTGAPRHQPTSTFSTAPSPAHPAKLRAQTTVPASAPGPPQPQPQAPSHPAGQSALPQGLVLTSQAQARLPSGEVVKIAQLASLAGPPSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQSYLRPPGPVVMQTVSQAGALNALGSKPPASGPSPTPVTPPVGVPGRVAVSPLAAGEPGAASKPASPVAGPTQEEKSRLLKERLDQIYFVNERRCSRSPIYGRDLLGICSLPGREQVPWFRASDRGHGKGAGPASRHTSPSKSHRDLILTLTQRQESLQDVIDRVVCVIPPVVAAPPHLWVARPPSLYSHRMRLFRHCLREHTAPYAQQLQRMTALHSLRFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYIRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGVSLVEADAVVFYDHDLNPVMDAKAQEWCDRIGRRKDVHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYPPMDDTGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEEDAQKPAEEAVPGSPDSSGSRWDEEPSQLEELADFMGQLTPIEKYALNYLELFHTSIDQEKERSSEGAVMTAVREWEARNAQSLREQEARARLEQEQEQLLTYTREDAYSAEFVCEGADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPESKLPPVYVRKERRRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRTTPGMLKIRREGKEQKKNILLKQQTQFAKPLPTFAKPTTESGPDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVLIPREEGKSKNNRPLRTGQMYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPPPPQPQPPPPQQPPPPLPQPSAAGSQQPAGPPAVQPQAQAQPPAQPAPPPPKAPPAITTVGSAAVLQAGAIKTSVTGTSMPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQPRAVGSPATATSDLVSLAPTQGVRAVTSVTASAVVTTSLTPVQTPTRSLVTQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQAASQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQLPQQAPPAQAPAGPPQPTAQVQVQPPQPTQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQAPAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHVQQLLKLKQQAVQQQKAIQPQAAPGPATVQQKITAQQIAAQGQPQKVTYATQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKIPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPAVTATAQVVQQKLMQQQVVTTAAAQLQTPGVPTPAQVPAASDSPNQQPKLQMRVPAVRLKTPTKPPCP", 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2Q0-1", "uniprot_ac": "A0AAA9T2Q0", "uniprot_id": "A0AAA9T2Q0_BOVIN", "mass": { "chemical_mass": 51580.0, "monoisotopic_mass": 51580.0 }, "refseq": { "ac": "XP_005225304", "name": "zinc finger protein 789 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225304" }, "gene_names": [ { "name": "ZNF789", "type": "recommended", "evidence": [ { "id": "A0AAA9T2Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ] }, { "name": "ZNF789", "type": "synonym", "evidence": [ { "id": "XP_005225304", "database": "RefSeq", "url": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HKQCHPQ", "url": "https://omabrowser.org/oma/group/HKQCHPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3MZC9", "url": "https://www.orthodb.org/?gene=G3MZC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14196:SF12", "url": 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"url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225304", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225304", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Z0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZC9", "url": "https://www.uniprot.org/uniprotkb/G3MZC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZC9-1", "url": "https://www.uniprot.org/uniprotkb/G3MZC9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARIQPHFGDQAMEAMFLPVPWKGLLSFEDVALYFTREEWDMLDWAQKALYRDVMLDNYRDVVSLGFQFPKPEVICQLEQWEEPWILDLPRAGTRKASGSACPDSEARFQTKELTPMENTSEDLMLWKMSALKQKTAKEPSEELCEYNELVDIYGFSLPATGDECCKDFLQSLNLIHSRRAQTWTQQGKYDEYGKPCHQRSQLLRHKRTLTNAKSYECHECGRAFQRQANFVRHQRLHSSENPFECDICGQAFKQKSTLIIHKQCHSQKKPYKCHDCGKCFRQMAYLVEHKRIHTKEKPYKCSKCERTFSQNSTLIRHQLIHSGEKPHKCTKCGKAFGRHSTLMSHQQIHSKQNAHKCSECGESFGRNVDLIQHQRIHTKEEFFECRECGKTFSFKANLHRHEVIHTGERPYRCDKCGKSFSWRTSFIKHQGTHREQVSA", "length": 440, "header": "tr|A0AAA9T2Q0-1|A0AAA9T2Q0_BOVIN Isoform 1 of Zinc finger protein 789 OS=Bos taurus OX=9913 GN=ZNF789 PE=3 SV=1 CANONICAL=A0AAA9T2Q0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0/entry#A0AAA9S1Z0-1", "sequence": { "sequence": "MARIQPHFGDQAMEAMFLPVPWKGLLSFEDVALYFTREEWDMLDWAQKALYRDVMLDNYRDVVSLDSEARFQTKELTPMENTSEDLMLWKMSALKQKTAKEPSEELCEYNELVDIYGFSLPATGDECCKDFLQSLNLIHSRRAQTWTQQGKYDEYGKPCHQRSQLLRHKRTLTNAKSYECHECGRAFQRQANFVRHQRLHSSENPFECDICGQAFKQKSTLIIHKQCHSQKKPYKCHDCGKCFRQMAYLVEHKRIHTKEKPYKCSKCERTFSQNSTLIRHQLIHSGEKPHKCTKCGKAFGRHSTLMSHQQIHSKQNAHKCSECGESFGRNVDLIQHQRIHTKEEFFECRECGKTFSFKANLHRHEVIHTGERPYRCDKCGKSFSWRTSFIKHQGTHREQVSA", "length": 402, "header": "tr|A0AAA9S1Z0-1|A0AAA9T2Q0_BOVIN Computationally mapped isoform of Zinc finger protein 789 OS=Bos taurus OX=9913 GN=ZNF789 PE=3 SV=2 CANONICAL=A0AAA9T2Q0-1" }, "locus": { "chromosome": "25", "start_pos": 36879531, "end_pos": 36872481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094415.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094415.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076090.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076090.2" } ] } }, { "isoform_ac": "A0AAA9T2Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0/entry#A0AAA9T2Q0-1", "sequence": { "sequence": "MARIQPHFGDQAMEAMFLPVPWKGLLSFEDVALYFTREEWDMLDWAQKALYRDVMLDNYRDVVSLGFQFPKPEVICQLEQWEEPWILDLPRAGTRKASGSACPDSEARFQTKELTPMENTSEDLMLWKMSALKQKTAKEPSEELCEYNELVDIYGFSLPATGDECCKDFLQSLNLIHSRRAQTWTQQGKYDEYGKPCHQRSQLLRHKRTLTNAKSYECHECGRAFQRQANFVRHQRLHSSENPFECDICGQAFKQKSTLIIHKQCHSQKKPYKCHDCGKCFRQMAYLVEHKRIHTKEKPYKCSKCERTFSQNSTLIRHQLIHSGEKPHKCTKCGKAFGRHSTLMSHQQIHSKQNAHKCSECGESFGRNVDLIQHQRIHTKEEFFECRECGKTFSFKANLHRHEVIHTGERPYRCDKCGKSFSWRTSFIKHQGTHREQVSA", "length": 440, "header": "tr|A0AAA9T2Q0-1|A0AAA9T2Q0_BOVIN Isoform 1 of Zinc finger protein 789 OS=Bos taurus OX=9913 GN=ZNF789 PE=3 SV=1 CANONICAL=A0AAA9T2Q0-1" }, "locus": { "chromosome": "25", "start_pos": 36879531, "end_pos": 36872481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113062.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113062.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093076.1" } ] } }, { "isoform_ac": "G3MZC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0/entry#G3MZC9-1", "sequence": { "sequence": "MKVKSESEVPQSCPTLSDPMDCSLPGSSVQGIFQLSLMARIQPHFGDQAMEAMFLPVPWKGLLSFEDVALYFTREEWDMLDWAQKALYRDVMLDNYRDVVSLGFQFPKPEVICQLEQWEEPWILDLPRAGTRKASGSACPDSEARFQTKELTPMENTSEDLMLWKMSALKQKTAKEPSEELCEYNELVDIYGFSLPATGDECCKDFLQSLNLIHSRRAQTWTQQGKYDEYGKPCHQRSQLLRHKRTLTNAKSYECHECGRAFQRQANFVRHQRLHSSENPFECDICGQAFKQKSTLIIHKQCHSQKKPYKCHDCGKCFRQMAYLVEHKRIHTKEKPYKCSKCERTFSQNSTLIRHQLIHSGEKPHKCTKCGKAFGRHSTLMSHQQIHSKQNAHKCSECGESFGRNVDLIQHQRIHTKEEFFECRECGKTFSFKANLHRHEVIHTGERPYRCDKCGKSFSWRTSFIKHQGTHREQVSA", "length": 477, "header": "tr|G3MZC9-1|G3MZC9_BOVIN Computationally mapped isoform of Zinc finger protein 789 OS=Bos taurus OX=9913 GN=ZNF789 PE=3 SV=3 CANONICAL=A0AAA9T2Q0-1" }, "locus": { "chromosome": "25", "start_pos": 36879531, "end_pos": 36871508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063489.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063489.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054925.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054925.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q5FWF6-1", "protein_name": "Zinc finger protein 789", "gene_name": "ZNF789", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFPPARGKELLSFEDVAMYFTREEWGHLNWGQKDLYRDVMLENYRNMVLLGFQFPKPEMICQLENWDEQWILDLPRTGNRKASGSACPGSEARHKMKKLTPKQKFSEDLESYKISVVMQESAEKLSEKLHKCKEFVDSCRLTFPTSGDEYSRGFLQNLNLIQDQNAQTRWKQGRYDEDGKPFNQRSLLLGHERILTRAKSYECSECGKVIRRKAWFDQHQRIHFLENPFECKVCGQAFRQRSALTVHKQCHLQNKPYRCHDCGKCFRQLAYLVEHKRIHTKEKPYKCSKCEKTFSQNSTLIRHQVIHSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPNTHKCSECGQSFGRNVDLIQHQRIHTKEEFFQCGECGKTFSFKRNLFRHQVIHTGSQPYQCVICGKSFKWHTSFIKHQGTHKGQIST", "length": 425 }, "evidence": [ { "id": "A0AAA9T2Q0", "url": "https://omabrowser.org/oma/group/A0AAA9T2Q0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 216, "end_pos": 243, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T2Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Q0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 97, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 312, "end_pos": 314 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T364-1", "uniprot_ac": "A0AAA9T364", "uniprot_id": "A0AAA9T364_BOVIN", "mass": { "chemical_mass": 29629.0, "monoisotopic_mass": 29629.0 }, "refseq": { "ac": "NP_001192622", "name": "BTB/POZ domain-containing protein KCTD21", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192622" }, "gene_names": [ { "name": "KCTD21", "type": "recommended", "evidence": [ { "id": "A0AAA9T364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ] }, { "name": "KCTD21", "type": "synonym", "evidence": [ { "id": "NP_001192622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192622" } ] } ], "protein_names": [ { "name": "BTB/POZ domain-containing protein KCTD21", "type": "synonym", "evidence": [ { "id": "NP_001192622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192622" } ] }, { "name": "Potassium channel tetramerization domain containing 21", "type": "synonym", "evidence": [ { "id": "A0AAA9T364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364/entry#names_and_taxonomy" } ] }, { "name": "potassium channel tetramerisation domain containing 21", "type": "synonym", "evidence": [ { "id": "NP_001192622", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192622" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCTD21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364", "locus": { "chromosome": "29", "start_pos": 17881793, "end_pos": 17859880, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054429", "url": "https://www.ensembl.org/id/ENSBTAG00000054429" } ] } } ], "crossref": [ { "id": "ENSBTAG00000054429", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054429", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18395", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18395", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539645", "url": "https://www.ncbi.nlm.nih.gov/gene/539645", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539645", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539645", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ANIFCTS", "url": "https://omabrowser.org/oma/group/ANIFCTS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MH86", "url": "https://www.orthodb.org/?gene=A0A3Q1MH86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14499:SF57", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14499:SF57", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19329", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19329", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192622", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S294", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S294", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S294-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S294-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T364-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHAVDFMNNKIIRLIRYR", "length": 260, "header": "tr|A0AAA9T364-1|A0AAA9T364_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 21 OS=Bos taurus OX=9913 GN=KCTD21 PE=4 SV=1 CANONICAL=A0AAA9T364-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MH86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364/entry#A0A3Q1MH86-1", "sequence": { "sequence": "MKFDARNAELQRAYWRTTSPREQRAGPGPPRPWAGLRPSAPLAKLRWPPAEGRLLSEGRRTIFLHPSLPAMSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHAVDFMNNKIIRLIRYR", "length": 330, "header": "tr|A0A3Q1MH86-1|A0A3Q1MH86_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 21 OS=Bos taurus OX=9913 GN=KCTD21 PE=4 SV=2 CANONICAL=A0AAA9T364-1" }, "locus": { "chromosome": "29", "start_pos": 17879155, "end_pos": 17860289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075746.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075746.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073603.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073603.2" } ] } }, { "isoform_ac": "A0AAA9S294-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364/entry#A0AAA9S294-1", "sequence": { "sequence": "MRECFAVQARTIFLHPSLPAMSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHAVDFMNNKIIRLIRYR", "length": 280, "header": "tr|A0AAA9S294-1|A0AAA9T364_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 21 OS=Bos taurus OX=9913 GN=KCTD21 PE=4 SV=1 CANONICAL=A0AAA9T364-1" }, "locus": { "chromosome": "29", "start_pos": 17879155, "end_pos": 17861517, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077819.1" } ] } }, { "isoform_ac": "A0AAA9T364-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364/entry#A0AAA9T364-1", "sequence": { "sequence": "MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHAVDFMNNKIIRLIRYR", "length": 260, "header": "tr|A0AAA9T364-1|A0AAA9T364_BOVIN Isoform 1 of Potassium channel tetramerization domain containing 21 OS=Bos taurus OX=9913 GN=KCTD21 PE=4 SV=1 CANONICAL=A0AAA9T364-1" }, "locus": { "chromosome": "29", "start_pos": 17879155, "end_pos": 17878376, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090657.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090657.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076993.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076993.1" } ] } }, { "isoform_ac": "A0AAA9TA87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364/entry#A0AAA9TA87-1", "sequence": { "sequence": "MRRTIFLHPSLPAMSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHAVDFMNNKIIRLIRYR", "length": 273, "header": "tr|A0AAA9TA87-1|A0AAA9TA87_BOVIN Computationally mapped isoform of Potassium channel tetramerization domain containing 21 OS=Bos taurus OX=9913 GN=KCTD21 PE=4 SV=1 CANONICAL=A0AAA9T364-1" }, "locus": { "chromosome": "29", "start_pos": 17879155, "end_pos": 17861331, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124940.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124940.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092881.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539645", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539645", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X454-1", "protein_name": "Potassium channel tetramerization domain containing 21", "gene_name": "KCTD21", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSEPITLNVGGKLYTTSLSTLTSFPDSMLGAMFSGKMPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQIQPLIEALQEKEVELSKAEKNAMLNISLDQKTQTVHFTVREAPQIYSLSSSNMEVFSAHIFSTSCLFLKLLGSKLYYCFNGNLSSISSYLQDPNHLTLDWVASVEGLPEEEYTKQNLKRLWVVPDNKQINSFQVFVEEMLKIAVSDGFCIDSSHPHTSDFMNNKIIRLIRYK", "length": 260 }, "evidence": [ { "id": "A0AAA9T364", "url": "https://omabrowser.org/oma/group/A0AAA9T364/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JKZ7-1", "protein_name": "BTB/POZ domain-containing protein KCTD21 isoform X1", "gene_name": "Kctd21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPELFPDTQPPAMSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEIELSKAEKNAMLNITLKQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR", "length": 272 }, "evidence": [ { "id": "A0AAA9T364", "url": "https://omabrowser.org/oma/group/A0AAA9T364/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4ADH5-1", "protein_name": "Potassium channel tetramerization domain containing 21", "gene_name": "Kctd21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEIELSKAEKNAMLNITLKQHVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQAFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR", "length": 260 }, "evidence": [ { "id": "A0AAA9T364", "url": "https://omabrowser.org/oma/group/A0AAA9T364/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4G0X4-1", "protein_name": "BTB/POZ domain-containing protein KCTD21", "gene_name": "KCTD21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR", "length": 260 }, "evidence": [ { "id": "A0AAA9T364", "url": "https://omabrowser.org/oma/group/A0AAA9T364/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" }, { "name": "negative regulation of smoothened signaling pathway", "id": "GO:0045879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" }, { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T364" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 72, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 170, "end_pos": 172 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T0Y5-1", "uniprot_ac": "A0AAA9T0Y5", "uniprot_id": "A0AAA9T0Y5_BOVIN", "mass": { "chemical_mass": 87483.0, "monoisotopic_mass": 87483.0 }, "refseq": {}, "gene_names": [ { "name": "POT1", "type": "recommended", "evidence": [ { "id": "A0AAA9T0Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5" } ] } ], "protein_names": [ { "name": "Protection of telomeres protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T0Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#names_and_taxonomy" } ] }, { "name": "POT1-like telomere end-binding protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T0Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5", "locus": { "chromosome": "4", "start_pos": 89092422, "end_pos": 89190579, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013180", "url": "https://www.ensembl.org/id/ENSBTAG00000013180" } ] } } ], "crossref": [ { "id": "A0AAA9T0Y5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T0Y5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013180", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013180", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04497", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04497", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04498", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04498", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511292", "url": "https://www.ncbi.nlm.nih.gov/gene/511292", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028389", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028389", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511292", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511292", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BGK3", "url": "https://www.orthodb.org/?gene=E1BGK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14513", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14513", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14513:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14513:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21375", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21375", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110330", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110330", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110331", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110331", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171306", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171306", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171319", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174414", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174414", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174417", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174417", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174437", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174437", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559586", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9670095", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9670095", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S2Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGK3", "url": "https://www.uniprot.org/uniprotkb/E1BGK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGK3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLELIKEVNGVPEVDLLNKLHKVDIRSLQPGSDYDKKYIQGKLSLISSLICGENRRAVLKIGLQEQDNSNSEISKINILFFGSLAKDCAKVFYEGDTIAVAGFVVLSASSSPSRDGKHCLFLKASENFKSTVYVYVKSVRDCSTESMSLAPATHYVYTPLNQLKGGMIVNVYGVVKFFKPPYLSRGTDYCSVVTIVDQTNVKLTCLFFSGNYEALPMIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTASKCFNFTAEDQKMVEALRIWASTHISPSSILVKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLMQDLALEGDLSRIHQLQNLTADILVYDNHVQVAKSLKVGSFLRIYSLHTKLQSVSSENLATSLALEFHLHGGTSYGRGIRVLPENNSDVDQLKKILESAHLPPNQSFGGVCQSEQEDSFSSSGSVSLYEVERCQQLSATILTDHQYLEKTPLCAILKQNAPQQYRIRAKLRSYKPRRLFQSVKLYCPKCHLLQEVPHEIDLDKILQEGTSKTPDTTLQNTSLYNSKVWTTKDQGERKVAIHFVKNNGILPLSNDCLILIEGGTLSEICKLSDKFHSVIPVRSGHEDLEILDLSAPFLIQGKIHHYGCKHCSSLRPIKNLNSLVNKTSWIPSSVAEALGIVPLQQVFVMTFTLDDGTGVLEAYLMDSENFFQIPASEVLNNDNLQHSMEMIMDMFCPPGAKIDAYPWLEFFIRSYNVTSGKEQQICYQIFDTTIADDVI", "length": 782, "header": "tr|A0AAA9T0Y5-1|A0AAA9T0Y5_BOVIN Isoform 1 of Protection of telomeres protein 1 OS=Bos taurus OX=9913 GN=POT1 PE=3 SV=2 CANONICAL=A0AAA9T0Y5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2Q7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#A0AAA9S2Q7-1", "sequence": { "sequence": "MPLELIKEVNGVPEVDLLNKLHKVDIRSLQPGSDYDKKYIQDTIAVAGFVVLSASSSPSRDGKHCLFLKASENFKSTVYVYVKSVRDCSTESMSLAPATHYVYTPLNQLKGGMIVNVYGVVKFFKPPYLSRGTDYCSVVTIVDQTNVKLTCLFFSGNYEALPMIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTASKCFNFTAEDQKMVEALRIWASTHISPSSILVKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLMQDLALEGDLSRIHQLQNLTADILVYDNHVQVAKSLKVGSFLRIYSLHTKLQSVSSENLATSLALEFHLHGGTSYGRGIRVLPENNSDVDQLKKILESAHLPPNQSFGGVCQSEQEDSFSNISSSGSVSLYEVERCQQLSATILTDHQYLEKTPLCAILKQNAPQQYRIRAKLRSYKPRRLFQSVKLYCPKCHLLQEVPHEIDLDKILQEGTSKTPDTTLQNTSLYNSKVWTTKDQGERKVAIHFVKNNGILPLSNDCLILIEGGTLSEICKLSDKFHSVIPVRSGHEDLEILDLSAPFLIQGKIHHYGCKHCSSLRPIKNLNSLVNKTSWIPSSVAEALGIVPLQQVFVMTFTLDDGTGVLEAYLMDSENFFQIPASEVLNNDNLQHSMEMIMDMFCPPGAKIDAYPWLEFFIRSYNVTSGKEQQICYQIFDTTIADDVI", "length": 730, "header": "tr|A0AAA9S2Q7-1|A0AAA9T0Y5_BOVIN Computationally mapped isoform of Protection of telomeres protein 1 OS=Bos taurus OX=9913 GN=POT1 PE=3 SV=1 CANONICAL=A0AAA9T0Y5-1" }, "locus": { "chromosome": "4", "start_pos": 89189372, "end_pos": 89093426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091007.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091007.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080205.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080205.1" } ] } }, { "isoform_ac": "A0AAA9T0Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#A0AAA9T0Y5-1", "sequence": { "sequence": "MPLELIKEVNGVPEVDLLNKLHKVDIRSLQPGSDYDKKYIQGKLSLISSLICGENRRAVLKIGLQEQDNSNSEISKINILFFGSLAKDCAKVFYEGDTIAVAGFVVLSASSSPSRDGKHCLFLKASENFKSTVYVYVKSVRDCSTESMSLAPATHYVYTPLNQLKGGMIVNVYGVVKFFKPPYLSRGTDYCSVVTIVDQTNVKLTCLFFSGNYEALPMIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTASKCFNFTAEDQKMVEALRIWASTHISPSSILVKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLMQDLALEGDLSRIHQLQNLTADILVYDNHVQVAKSLKVGSFLRIYSLHTKLQSVSSENLATSLALEFHLHGGTSYGRGIRVLPENNSDVDQLKKILESAHLPPNQSFGGVCQSEQEDSFSSSGSVSLYEVERCQQLSATILTDHQYLEKTPLCAILKQNAPQQYRIRAKLRSYKPRRLFQSVKLYCPKCHLLQEVPHEIDLDKILQEGTSKTPDTTLQNTSLYNSKVWTTKDQGERKVAIHFVKNNGILPLSNDCLILIEGGTLSEICKLSDKFHSVIPVRSGHEDLEILDLSAPFLIQGKIHHYGCKHCSSLRPIKNLNSLVNKTSWIPSSVAEALGIVPLQQVFVMTFTLDDGTGVLEAYLMDSENFFQIPASEVLNNDNLQHSMEMIMDMFCPPGAKIDAYPWLEFFIRSYNVTSGKEQQICYQIFDTTIADDVI", "length": 782, "header": "tr|A0AAA9T0Y5-1|A0AAA9T0Y5_BOVIN Isoform 1 of Protection of telomeres protein 1 OS=Bos taurus OX=9913 GN=POT1 PE=3 SV=2 CANONICAL=A0AAA9T0Y5-1" }, "locus": { "chromosome": "4", "start_pos": 89189372, "end_pos": 89093426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091358.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091358.2" } ] } }, { "isoform_ac": "A0AAA9TQZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#A0AAA9TQZ6-1", "sequence": { "sequence": "MPLELIKEVNGVPEVDLLNKLHKVDIRSLQPGSDYDKKYIQGKLSLISSLICGENRRAVLKIGLQEQDNSNSEISKINILFFGSLAKDCAKVFYEGDTIAVAGFVVLSASSSPSRDGKHCLFLKASENFKSTVYAPATHYVYTPLNQLKGGMIVNVYGVVKFFKPPYLSRGTDYCSVVTIVDQTNVKLTCLFFSGNYEALPMIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTASKCFNFTAEDQKMVEALRIWASTHISPSSILVKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLMQDLALEGDLSRIHQLQNLTADILVYDNHVQVAKSLKVGSFLRIYSLHTKLQSVSSENLATSLALEFHLHGGTSYGRGIRVLPENNSDVDQLKKILESAHLPPNQSFGGVCQSEQEDSFSNISSSGSVSLYEVERCQQLSATILTDHQYLEKTPLCAILKQNAPQQYRIRAKLRSYKPRRLFQSVKLYCPKCHLLQEVPHEIDLDKILQEGTSKTPDTTLQNTSLYNSKVWTTKDQGERKVAIHFVKNNGILPLSNDCLILIEGGTLSEICKLSDKFHSVIPVRSGHEDLEILDLSAPFLIQGKIHHYGCKHCSSLRPIKNLNSLVNKTSWIPSSVAEALGIVPLQQVFVMTFTLDDGTGVLEAYLMDSENFFQIPASEVLNNDNLQHSMEMIMDMFCPPGAKIDAYPWLEFFIRSYNVTSGKEQQICYQIFDTTIADDVI", "length": 769, "header": "tr|A0AAA9TQZ6-1|A0AAA9TQZ6_BOVIN Computationally mapped isoform of Protection of telomeres protein 1 OS=Bos taurus OX=9913 GN=POT1 PE=3 SV=1 CANONICAL=A0AAA9T0Y5-1" }, "locus": { "chromosome": "4", "start_pos": 89189372, "end_pos": 89093426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104106.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104106.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099433.1" } ] } }, { "isoform_ac": "E1BGK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Y5/entry#E1BGK3-1", "sequence": { "sequence": 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"url": "https://www.uniprot.org/uniprotkb/F1MDE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILRCSLSTLTPRTRVSLYSVLATPWIPRTSSSGYTLGRSTPPALPFLAEPDLEKPQRSGRSLRISGGNRPVFLRNLHPAFYSTCNNLHCTWDSFECIGLHGQVTAIHADLCRPDAENAFKVRLSIRTALGDKAYAWDANEEYLFKAMVAFSMRKVPNRETTEISHVLLCNVTQRVSFWFVVTDPSRNHTLPAVEVQSAIRMNRNRINNAFFLNDQTLEFLRIPSTLAPPTDPSVPIWIIIFGVIFCIVLVATMLLIISGIRQHRRKNKGPSEMEDSEDKCENVITIENGIPCDPLDMKGGHINDAFVTEDERLTPL", "length": 317, "header": "tr|A0AAA9T400-1|A0AAA9T400_BOVIN Isoform 1 of Collectrin, amino acid transport regulator OS=Bos taurus OX=9913 GN=CLTRN PE=4 SV=1 CANONICAL=A0AAA9T400-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S353-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400/entry#A0AAA9S353-1", "sequence": { "sequence": "MILRCSLSTLTPRTRVSLYSVLATPWIPRTSSSGYTLGRSTPPALPFLAEPDLEKPQRSGRSLRISGGNRPVFLRNLHPAFYSTCNNLHCTWDSFECIGLHGQDAENAFKVRLSIRTALGDKAYAWDANEEYLFKAMVAFSMRKVPNRETTEISHVLLCNVTQRVSFWFVVTDPSRNHTLPAVEVQSAIRMNRNRINNAFFLNDQTLEFLRIPSTLAPPTDPSVPIWIIIFGVIFCIVLVATMLLIISGIRQHRRKNKGPSEMEDSEDKCENVITIENGIPCDPLDMKGGHINDAFVTEDERLTPL", "length": 306, "header": "tr|A0AAA9S353-1|A0AAA9T400_BOVIN Computationally mapped isoform of Collectrin, amino acid transport regulator OS=Bos taurus OX=9913 GN=CLTRN PE=4 SV=1 CANONICAL=A0AAA9T400-1" }, "locus": { "chromosome": "X", "start_pos": 127877586, "end_pos": 127831244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111789.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111789.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078185.1" } ] } }, { "isoform_ac": "A0AAA9T400-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400/entry#A0AAA9T400-1", "sequence": { "sequence": "MILRCSLSTLTPRTRVSLYSVLATPWIPRTSSSGYTLGRSTPPALPFLAEPDLEKPQRSGRSLRISGGNRPVFLRNLHPAFYSTCNNLHCTWDSFECIGLHGQVTAIHADLCRPDAENAFKVRLSIRTALGDKAYAWDANEEYLFKAMVAFSMRKVPNRETTEISHVLLCNVTQRVSFWFVVTDPSRNHTLPAVEVQSAIRMNRNRINNAFFLNDQTLEFLRIPSTLAPPTDPSVPIWIIIFGVIFCIVLVATMLLIISGIRQHRRKNKGPSEMEDSEDKCENVITIENGIPCDPLDMKGGHINDAFVTEDERLTPL", "length": 317, "header": "tr|A0AAA9T400-1|A0AAA9T400_BOVIN Isoform 1 of Collectrin, amino acid transport regulator OS=Bos taurus OX=9913 GN=CLTRN PE=4 SV=1 CANONICAL=A0AAA9T400-1" }, "locus": { "chromosome": "X", "start_pos": 127877586, "end_pos": 127831244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117853.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117853.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090425.1" } ] } }, { "isoform_ac": "A0AAF6ZQV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400/entry#A0AAF6ZQV9-1", "sequence": { "sequence": "MTWMDPREVFLRNLHPAFYSTCNNLHCTWDSFECIGLHGQDAENAFKVRLSIRTALGDKAYAWDANEEYLFKAMVAFSMRKVPNRETTEISHVLLCNVTQRVSFWFVVTDPSRNHTLPAVEVQSAIRMNRNRINNAFFLNDQTLEFLRIPSTLAPPTDPSVPIWIIIFGVIFCIVLVATMLLIISGIRQHRRKNKGPSEMEDSEDKCENVITIENGIPCDPLDMKGGHINDAFVTEDERLTPL", "length": 243, "header": "tr|A0AAF6ZQV9-1|A0AAF6ZQV9_BOVIN Computationally mapped isoform of Collectrin, amino acid transport regulator OS=Bos taurus OX=9913 GN=CLTRN PE=4 SV=1 CANONICAL=A0AAA9T400-1" }, "locus": { "chromosome": "X", "start_pos": 127877586, "end_pos": 127828547, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063008.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063008.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055619.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055619.3" } ] } }, { "isoform_ac": "F1MDE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400/entry#F1MDE7-1", "sequence": { "sequence": "MIKRNAEETWTYSVCKAIHHFVHSYAWDANEEYLFKAMVAFSMRKVPNRETTEISHVLLCNVTQRVSFWFVVTDPSRNHTLPAVEVQSAIRMNRNRINNAFFLNDQTLEFLRIPSTLAPPTDPSVPIWIIIFGVIFCIVLVATMLLIISGIRQHRRKNKGPSEMEDSEDKCENVITIENGIPCDPLDMKGGHINDAFVTEDERLTPL", "length": 207, "header": "tr|F1MDE7-1|A0AAA9T400_BOVIN Computationally mapped isoform of Collectrin, amino acid transport regulator OS=Bos taurus OX=9913 GN=CLTRN PE=4 SV=3 CANONICAL=A0AAA9T400-1" }, "locus": { "chromosome": "X", "start_pos": 127877586, "end_pos": 127843007, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044234.6", "url": "https://www.ensembl.org/id/ENSBTAT00000044234.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041744.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041744.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T400", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T400", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400" } ], "pmid": "" }, { "name": "brush border membrane", "id": "GO:0031526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031526", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T400", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T400", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:1905737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T400", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T400", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T400" }, { "id": "PS52010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Collectrin-like", "eco_id": "ECO_0000259", "start_pos": 116, "end_pos": 317, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], 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"database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XAKERSE", "url": "https://omabrowser.org/oma/group/XAKERSE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGR2", "url": "https://www.orthodb.org/?gene=F1MGR2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10126", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10126", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690959", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR2", "url": "https://www.uniprot.org/uniprotkb/F1MGR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR2-1", "url": "https://www.uniprot.org/uniprotkb/F1MGR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGWVRSSATPSLVHHLFPPAICGSVDVGDQARPPARPLVPCSQPWPRPRLATSSRGPINGFCAPHAWPTQPQLHSLWLFPPFPTSQLPTVSPPPMEETYLELYLDQCSAQDALTPSRSPLLSPAVPYDVDMLTSSNPETAFNPQLEEVTEASGSFSAVDLSFLPDELSQENKDQTVIRSKHEVEENCKTQSRQIRLPLPSQLDAGLALNSSSGSGSHSHLHPADGNSAQPSPEKPHSMPLASITPMTPMAPISECSGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFTIQNMVASCDVRFPISLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKKRSDIYEAFENIYPILKGFKKA", "length": 435, "header": "tr|A0AAA9T1L9-1|A0AAA9T1L9_BOVIN Isoform 1 of TATA-box binding protein like 2 OS=Bos taurus OX=9913 GN=TBPL2 PE=3 SV=1 CANONICAL=A0AAA9T1L9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9/entry#A0AAA9S3V8-1", "sequence": { "sequence": "MGWVRSSATPSLVHHLFPPAICGSVDVGDQARPPARPLVPCSQPWPRPRLATSSRGPINGFCAPHAWPTQPQLHSLWLFPPFPTSQLPTVSPPPMEETYLELYLDQCSAQDALTPSRSPLLSPAVPYDVDMLTSSNPETAFNPQLEEVTEASGSFSAVDLSFLPDELSQENKDQTVIRSKHEVEENCKTQSRQIRLPLPSQLDAGLALNSSSGSGSHSHLHPADGNSAQPSPEKPHSMPLASITPMTPMAPISECSGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFTIQNMVASCDVRFPISLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTERNLE", "length": 415, "header": "tr|A0AAA9S3V8-1|A0AAA9T1L9_BOVIN Computationally mapped isoform of TATA-box binding protein like 2 OS=Bos taurus OX=9913 GN=TBPL2 PE=3 SV=1 CANONICAL=A0AAA9T1L9-1" }, "locus": { "chromosome": "10", "start_pos": 67907898, "end_pos": 67879706, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110095.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076796.1" } ] } }, { "isoform_ac": "A0AAA9SY86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9/entry#A0AAA9SY86-1", "sequence": { "sequence": "MGWVRSSATPSLVHHLFPPAICGSVDVGDQARPPARPLVPCSQPWPRPRLATSSRGPINGFCAPHAWPTQPQLHSLWLFPPFPTSQLPTVSPPPMEETYLELYLDQCSAQDALTPSRSPLLSPAVPYDVDMLTSSNPETAFNPQLEEVTEASGSFSAVDLSFLPDELSQENKDQTVIRSKHEVEENCKTQSRQIRLPLPSQLDAGLALNSSSGSGSHSHLHPADGNSAQPSPEKPHSMPLASITPMTPMAPISECSGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFTIQNMVASCDVRFPISLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGDGSKVQCCKKQYCIGTWNVRSMNQGKLEVVKQKMARVNINILGISELKWTGMGKFNSDDHYIYYCGQESLRRNEVALIVNKRVRNAVLECKLKNDRMISVCFQGKPFNITVIQVYAPTSNTEEAEVEWFYEDLQDLLELIPKRDVLFIIGDWNAKVGSQEIPVVTGKFGLEIQNEAGQRLTEFCQENTLVIANTLFQQHKRRFYTWTSPDGQH", "length": 624, "header": "tr|A0AAA9SY86-1|A0AAA9T1L9_BOVIN Computationally mapped isoform of TATA-box binding protein like 2 OS=Bos taurus OX=9913 GN=TBPL2 PE=3 SV=1 CANONICAL=A0AAA9T1L9-1" }, "locus": { "chromosome": "10", "start_pos": 67907898, "end_pos": 67886240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098234.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098234.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089215.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089215.1" } ] } }, { "isoform_ac": "A0AAA9T1L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9/entry#A0AAA9T1L9-1", "sequence": { "sequence": "MGWVRSSATPSLVHHLFPPAICGSVDVGDQARPPARPLVPCSQPWPRPRLATSSRGPINGFCAPHAWPTQPQLHSLWLFPPFPTSQLPTVSPPPMEETYLELYLDQCSAQDALTPSRSPLLSPAVPYDVDMLTSSNPETAFNPQLEEVTEASGSFSAVDLSFLPDELSQENKDQTVIRSKHEVEENCKTQSRQIRLPLPSQLDAGLALNSSSGSGSHSHLHPADGNSAQPSPEKPHSMPLASITPMTPMAPISECSGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFTIQNMVASCDVRFPISLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKKRSDIYEAFENIYPILKGFKKA", "length": 435, "header": "tr|A0AAA9T1L9-1|A0AAA9T1L9_BOVIN Isoform 1 of TATA-box binding protein like 2 OS=Bos taurus OX=9913 GN=TBPL2 PE=3 SV=1 CANONICAL=A0AAA9T1L9-1" }, "locus": { "chromosome": "10", "start_pos": 67907898, "end_pos": 67880966, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130473.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130473.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092680.1" } ] } }, { "isoform_ac": "F1MGR2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9/entry#F1MGR2-1", "sequence": { "sequence": "MGWVRSSATPSLVHHLFPPAICGSVDVGDQARPPARPLVPCSQPWPRPRLATSSRGPINGFCAPHAWPTQPQLHSLWLFPPFPTSQLPTVSPPPMEETYLELYLDQCSAQDALTPSRSPLLSPAVPYDVDMLTSSNPETAFNPQLEEVTEASGSFSAVDLSFLPDELSQENKDQTVIRSKHEVEENCKTQSRQIRLPLPSQLDAGLALNSSSGSGSHSHLHPADGNSAQPSPEKPHSMPLASITPMTPMAPISECSGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFTIQNMVASCDVRFPISLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKAAVSTSKATTE", "length": 424, "header": "tr|F1MGR2-1|F1MGR2_BOVIN Computationally mapped isoform of TATA-box binding protein like 2 OS=Bos taurus OX=9913 GN=TBPL2 PE=3 SV=4 CANONICAL=A0AAA9T1L9-1" }, "locus": { "chromosome": "10", "start_pos": 67907898, "end_pos": 67889519, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024325.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024325.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024325.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024325.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 9, "start_aa": "Thr", "end_pos": 9, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr9", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615096", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615096", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6H909-1", "protein_name": "TATA box-binding protein-like 2", "gene_name": "Tbpl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEEDMYVDIFLDPYTFQDDFPPATSQLFSPGAPLDVHPLNPSNPETVFHSHLGAVKKAPSDFSSVDLSFLPDELTQENKDRTVTGNKVTNEESFRTQDWQSQLQLPDEQGSGLNLNSNSSPDTQSCLCSHDADSNQLSSETPNSNALPVVLISSMTPMNPVTECSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEDESRLAARKYARVVQKLGFPVRFFNFKIQNMVASCDVKFPIRLEILALTHRQFSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV", "length": 344 }, "evidence": [ { "id": "A0AAA9T1L9", "url": "https://omabrowser.org/oma/group/A0AAA9T1L9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6SJ95-1", "protein_name": "TATA box-binding protein-like 2", "gene_name": "Tbpl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGSLIMEEDIYLDLFLDPYTIQDDFPPAMSQLFSPGVPLDMHSLPSNPETVFHPHLGGVKKASTDFSSVDLSFLPDELTQENRDQTVTGNKLASEESCRTRDRQSQLQLPDEHGSELNLNSNSSPDPQSCLCFDDAHSNQPSPETPNSNALPVALIASMMPMNPVPGFSGIVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKKV", "length": 350 }, "evidence": [ { "id": "A0AAA9T1L9", "url": "https://omabrowser.org/oma/group/A0AAA9T1L9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6SJ96-1", "protein_name": "TATA box-binding protein-like 2", "gene_name": "TBPL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQEETYLELYLDQCAAQDGLAPPRSPLFSPVVPYDMYILNASNPDTAFNSNPEVKETSGDFSSVDLSFLPDEVTQENKDQPVISKHETEENSESQSPQSRLPSPSEQDVGLGLNSSSLSNSHSQLHPGDTDSVQPSPEKPNSDSLSLASITPMTPMTPISECCGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKKA", "length": 343 }, "evidence": [ { "id": "A0AAA9T1L9", "url": "https://omabrowser.org/oma/group/A0AAA9T1L9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9" } ], "pmid": "" }, { "name": "catalytic activity", "id": "GO:0003824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription initiation", "id": "GO:0006352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 9 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 209, "end_pos": 211 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4S3-1", "uniprot_ac": "A0AAA9T4S3", "uniprot_id": "A0AAA9T4S3_BOVIN", "mass": { "chemical_mass": 133924.0, "monoisotopic_mass": 133924.0 }, "refseq": {}, "gene_names": [ { "name": "LOC520016", "type": "recommended", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] } ], "protein_names": [ { "name": "Multidrug resistance-associated protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.3", "type": "synonym", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MCF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF0#function" }, { "database": "UniProtKB", "id": "ARBA00094206", "url": "https://www.uniprot.org/uniprotkb/ARBA00094206#function" }, { "database": "UniProtKB", "id": "A0A3Q1N659", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N659#function" }, { "database": "UniProtKB", "id": "A0AAA9S4U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U5#function" }, { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC520016", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3", "locus": {} } ], "crossref": [ { "id": "A0AAA9T4S3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4S3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045751", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045751", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCF0", "url": "https://www.orthodb.org/?gene=A0A3Q1MCF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR23", "url": "https://www.orthodb.org/?gene=A0A3Q1MR23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N659", "url": "https://www.orthodb.org/?gene=A0A3Q1N659", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "66424", "url": "https://www.rhea-db.org/rhea/66424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MCF0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCF0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N659", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N659", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N659-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N659-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S582", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S582", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S582-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S582-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSKALEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKIQLFQCQASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLCTQVNVQSDLYSGVLVKEDEFIVFILNWYLGVYSGLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEVQLKDTIEHLPGKMNTELAESGLNLSVGQRQLVCLARAILKKNQILIIDKATSNVDPSTDKLIQRKIHEKFAQCTVITITHRLSNVIDCEWILVLDSGIYREAGEPHNLMQNENSLFYKMVQQLGQAEVSSLRGVVIKVCLQGSVFTISTGGLITKLGPVFPSMLPVPSRR", "length": 1192, "header": "tr|A0AAA9T4S3-1|A0AAA9T4S3_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=2 CANONICAL=A0AAA9T4S3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0A3Q1MCF0-1", "sequence": { "sequence": "MTSKALEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKNFLLLDETSQCYPQLPSDGRTIVDVQAFTAFGEKASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLCTQVNVQSDLYSGVLVKEDEFIVFILNWYLGVYSGLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEVQLKDTIEHLPGKMNTELAESGLNLSVGQRQLVCLARAILKKNQILIIDKATSNVDPSTDKLIQRKIHEKFAQCTVITITHRLSNVIDCEWILVLDSGIYREAGEPHNLMQNENSLFYKMVQQLGQAEVTALTERAK", "length": 1185, "header": "tr|A0A3Q1MCF0-1|A0A3Q1MCF0_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=2 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 140625, "end_pos": 2104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069831.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069831.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068499.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068499.2" } ] } }, { "isoform_ac": "A0A3Q1MR23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0A3Q1MR23-1", "sequence": { "sequence": "MTSKALEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKIQLFQCQASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLCTQVNVQSDLYSGVLVKEDEFIVFILNWYLGVYSGLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEMGKQWKQWLTLFFWAPKSLQMVTAAMKLRHLLLGRKL", "length": 1058, "header": "tr|A0A3Q1MR23-1|A0AAA9T4S3_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=3 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 124268, "end_pos": 2104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086789.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086789.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056827.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056827.3" } ] } }, { "isoform_ac": "A0A3Q1N659-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0A3Q1N659-1", "sequence": { "sequence": "MCQLEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKNFLLLDETSQCYPQLPSDGRTIVDVQAFTAFGEKASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKDLQLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLWLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEVQLKDTIEHLPGKMNTELAESGLNLSVGQRQLVCLARAILKKNQILIIDKATSNVDPSTDKLIQRKIHEKFAQCTVITITHRLSNVIDCEWILVLDSGIYREAGEPHNLMQNENSLFYKMVQQLGQAEVTALTERPDVTHSNLVVMNISSGQPSALTIFESTLILP", "length": 1181, "header": "tr|A0A3Q1N659-1|A0AAA9T4S3_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=3 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 147530, "end_pos": 1574, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069590.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069590.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065890.3", "url": "https://www.ensembl.org/id/ENSBTAP00000065890.3" } ] } }, { "isoform_ac": "A0AAA9S4U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0AAA9S4U5-1", "sequence": { "sequence": "GSALRSTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKNFLLLDETSQCYPQLPSDGRTIVDVQAFTAFGEKASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKDLQLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLWLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEVQLKDTIEHLPGKMNTELAESGLNLSVGQRQLVCLARAILKKNQILIIDKATSNVDPSTDKLIQRKIHEKFAQCTVITITHRLSNVIDCEWILVLDSGIYREAGEPHNLMQNENSLFYKMVQQLGQAEVTALTERPDVTHSNLVVMNISSGQPSALTIFESTLILP", "length": 1181, "header": "tr|A0AAA9S4U5-1|A0AAA9T4S3_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=2 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 147530, "end_pos": 1757, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080955.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080955.2" } ] } }, { "isoform_ac": "A0AAA9S582-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0AAA9S582-1", "sequence": { "sequence": "MTSKALEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLREVITDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKIQLFQCQASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLCTQVNVQSDLYSGVLVKEDEFIVFILNWYLGVYSGLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEETVACQASLSMEFSRQEYWSGLPFPCPGDLLNPGIEP", "length": 1027, "header": "tr|A0AAA9S582-1|A0AAA9T4S3_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=2 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 123874, "end_pos": 2104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108709.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108709.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080338.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080338.2" } ] } }, { "isoform_ac": "A0AAA9T4S3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3/entry#A0AAA9T4S3-1", "sequence": { "sequence": "MTSKALEGTRVVQPIFLGKMISYVENYDPTDSAALHEACGYAAGLSACVLLWAVLHHLCFYHMQRVGMRLRVAVCHMIYRKALRLSSSAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAIAVTALLWMEIGMSCLAGMVVLIILLLLQSCFGMLFSSLRSKTAALTDKRIRTISEVITGIRTIKMNAWEKSFIDLITRLRKKEISKILRSSYLRGMNLATFFAVSKIMIFVTFIANELLDNLITASQVFVVVTLFEALRFSSTLYFPMAVEKVSEAVVSIRRIKIQLFQCQASETPTLQGLSFTVRPGELLAVIGPVGAGKSSLLRALLGELPRSQGQVHVHGRVAYVPQQPWEFPGTVKSNILFGKKYEKERYEKVIEACALKKLLEEGDLTEIGDRGIPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDAIVSRHLFEQCVRQALKEKITILVTHQLQYLKYASQILILKDGKMVERGTYSEFLKSRVDIFSLFEKVNEQSEPSAVPGTPTVISESLVQSLQSPRPSLKDAAPEDQESENIQVTLPLEDHLGGKVGFKTYKNYFTGGADWLVIIFLILVNIAAQVRKGVYFDLCTQVNVQSDLYSGVLVKEDEFIVFILNWYLGVYSGLTVSTVLFGITKSLLIFYILVNSSLTLHNRMLETILRAPVLFFHRNPIGRILNRFSKDIGHMDDLLPLIFQDFIQAFLLVIGVVGMMVAAVPWTAIPVIPLGIIFFFLRRYFLETSRDVKRLECTTRSLVFSHLASSIRGLWTIRAYKAEQKFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVTCAIFVTLVAFGALILAETLDLGQVGLVLSLTLTLTGMFQWCVRQSAEIENMMVSVERGIEYTDLEKEAPWELEYRPPPFWPPNGRISFSSVNFRYNSDSPLVLRNLEEIINSGEKYGIVGRTGAGKSSLIAALFRLSEPEGDICIDDILTTYIGLHDLRKKMSVAPQEPVLFTGRMRNNLDPFNEHTDEELWNVLEEVQLKDTIEHLPGKMNTELAESGLNLSVGQRQLVCLARAILKKNQILIIDKATSNVDPSTDKLIQRKIHEKFAQCTVITITHRLSNVIDCEWILVLDSGIYREAGEPHNLMQNENSLFYKMVQQLGQAEVSSLRGVVIKVCLQGSVFTISTGGLITKLGPVFPSMLPVPSRR", "length": 1192, "header": "tr|A0AAA9T4S3-1|A0AAA9T4S3_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC520016 PE=3 SV=2 CANONICAL=A0AAA9T4S3-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 141208, "end_pos": 2104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092812.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092812.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "ABC-type glutathione S-conjugate transporter activity", "id": "GO:0015431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4S3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "66424", "name": "", "equation": "leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZT1-1", "A0AAA9T569-1", "A0AAA9SJG6-1", "A0AAA9TUR1-1", "A0AAA9S3M4-1", "G3MW08-1", "A0AAA9TZ11-1", "A0A3Q1LXZ2-1", "A0AAA9T4S3-1", "A0A3Q1LPI1-1", "A0AAA9TR50-1", "A0A3Q1ML89-1", "A0AAA9SMB4-1" ], "evidence": [ { "id": "66424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66424" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LPI1", "gene_name": "LOC107131247", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] } ] }, { "uniprot_ac": "A0A3Q1LXZ2", "gene_name": "LOC521568", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] } ] }, { "uniprot_ac": "A0A3Q1ML89", "gene_name": "LOC100299180", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] } ] }, { "uniprot_ac": "A0AAA9RZT1", "gene_name": "LOC100337390", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] } ] }, { "uniprot_ac": "A0AAA9S3M4", "gene_name": "LOC100848700", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] } ] }, { "uniprot_ac": "A0AAA9SJG6", "gene_name": "LOC101906567", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] } ] }, { "uniprot_ac": "A0AAA9SMB4", "gene_name": "LOC100847574", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SMB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMB4" } ] } ] }, { "uniprot_ac": "A0AAA9T4S3", "gene_name": "LOC520016", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" } ] } ] }, { "uniprot_ac": "A0AAA9T569", "gene_name": "ABCC4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] } ] }, { "uniprot_ac": "A0AAA9TR50", "gene_name": "LOC509854", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR50" } ] } ] }, { "uniprot_ac": "A0AAA9TUR1", "gene_name": "LOC528412", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TUR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUR1" } ] } ] }, { "uniprot_ac": "A0AAA9TZ11", "gene_name": "", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9TZ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ11" } ] } ] }, { "uniprot_ac": "G3MW08", "gene_name": "LOC100337076", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "G3MW08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MW08" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" }, { "id": "PS50929", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50929" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transmembrane type-1", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 262, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4S3" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 287, "end_pos": 507, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.6.2.2", "ec_name": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2" }, { "id": "7.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.2" } ] }, { "ec_number": "7.6.2.3", "ec_name": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "7.6.2.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3" }, { "id": "7.6.2.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1045, "end_pos": 1047 }, { "start_pos": 661, "end_pos": 663 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T234-1", "uniprot_ac": "A0AAA9T234", "uniprot_id": "A0AAA9T234_BOVIN", "mass": { "chemical_mass": 113183.0, "monoisotopic_mass": 113183.0 }, "refseq": {}, "gene_names": [ { "name": "KIF28", "type": "recommended", "evidence": [ { "id": "A0AAA9T234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ] } ], "protein_names": [ { "name": "Kinesin-like protein 6", "type": "recommended", "evidence": [ { "id": "A0AAA9T234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MN62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN62#function" }, { "database": "UniProtKB", "id": "ARBA00054688", "url": "https://www.uniprot.org/uniprotkb/ARBA00054688#function" }, { "database": "UniProtKB", "id": "A0AAA9S589", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S589#function" }, { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], 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"id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HMVITIH", "url": "https://omabrowser.org/oma/group/HMVITIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MN62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MN62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MN62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S589", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S589", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S589-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S589-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T234-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ95", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SARCNQGRVSVPCREKNSGSKCVISMHSRTTTIIQDPKNPGHTKTFTFDLAYWSHSGFQKDKDGVFISADRGSKFAGQKEVFHDLGRGILDSAWQGYNTTLLAYGQTGSGKSYSMIGFGANKGIIPNVCEELFQAIENRDKNQEYQVTFSMLEIYNEQVRDLLSRIKKPGGLKVREDQQLGFYVDGLQSVPCENYAQIERLMEQGAKIRTTASTNMNASSSRSHMVITIQFKQVFPDRGLTKQSSINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTNLGNVISALADAAMGKKVLHVPYRDSVLTKLLQSALGGNSRTTLIAAISPADICYEETLSTLRYAERYDYEYLLSIVVLKRAMSQPHFAISIFWVMRSLEDWEQWIGRNFALCAVLPRLVRIPSLFLLQEQQMIKTFPHLLNVNEDPQLTGVLKHFIQAGSCDAGKAASNAITLQGLGISEKHASFTNSGGKVTVTPYGKCKVIVNGVPITTKTKLQHLDRIILGSNSAYLYIGFPSERGSEDLSRFDYDFFQLERAAAEGVSTDKLGAVNSGDGKADPSVLAVFQDYVKLMPLVAEANQMSEELKKGLNMELKVKNLASSDSRGCDLQKEVTVKVTHQRTHQVWIWSKAKFINRKFLMEELYQRFLDGEDSQVAQEDDPFWDPVEVVHLGSAHIWLQSLAYCMKFEEQVEFLNCDGLEEAVLHIHIKPCSPTGQARGEEDVVTDPVDLLGKRMDFQIRLVQCLGTKWLKEDAERGVQMGYRIYDLPNTLYTKPVWKIVNPQIDETVQFTTLNASQEFLNYLQTNALIVDLWGLQEGCAELSCSRLDLMVTGEGHILVDTKKISTSTSNQIPELYLKLLKLEQETELLRNINRVLREENVLLKESIERTSSSQQGERPTGASITRMTAQGPLARDINQICTTQQVSYDREFARALKVFYQSINVARGQFLKLRHYKPPEDDQMLRPFVHQQSQMLKDFGDLLESSLWKLKNDVALIVKQKKECLLHAE", "length": 1006, "header": "tr|A0AAA9T234-1|A0AAA9T234_BOVIN Isoform 1 of Kinesin-like protein 6 OS=Bos taurus OX=9913 GN=KIF28 PE=3 SV=1 CANONICAL=A0AAA9T234-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MN62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234/entry#A0A3Q1MN62-1", "sequence": { "sequence": "MHSRTTTIIQDPKNPGHTKTFTFDLAYWSHSGFQKDKDGVFISADRGSKFAGQKEVFHDLGRGILDSAWQGYNTTLLAYGQTGSGKSYSMIGFGANKGIIPNVCEELFQAIENRDKNQEYQFALLVLPQVRDLLSRIKKPGGLKVREDQQLGFYVDGLQSVPCENYAQIERLMEQGAKIRTTASTNMNASSSRSHMVITIQFKQVFPDRGLTKQSSINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTNLGNVISALADAAMGKKVLHVPYRDSVLTKLLQSALGGNSRTTLIAAISPADICYEETLSTLRYAERYDYEYLLSIVRAMSQPHFAISIFWVMRSLEDWEQWIGRNFALCAVLPRLVRIPSLFLLQEQQMIKTFPHLLNVNEDPQLTGVLKHFIQAGSCDAGKAASNAITLQGLGISEKHASFTNSGGKVTVTPYGKCKVIVNGVPITTKTKLQHLDRIILGSNSAYLYIGFPSERGSEDLSRFDYDFFQLERAAAEGVSTDKLGAVNSGDGKADPSVLAVFQDYVKLMPLVAEANQMSEELKKGLNMELKVKNLASSDSRGCDLQKEVTVKVTHQRTHQVWIWSKAKFINRKFLMEELYQRFLDGEDSQVAQEDDPFWDPVEVVHLGSAHIWLQSLAYCMKFEEQVEFLNCDGLEEAVLHIHIKPCSPTGQARGEEDVVTDPVDLLGKRMDFQIRLVQCLGTKWLKEDAERGVQMGYRIYDLPNTLYTKPVWKIVNPQIDETVQFTTLNASQEFLNYLQTNALIVDLWGLQEGCAELSCSRLDLMVTGEGHILVDTKKISTSTSNQIPELYLKLLKLEQETELLRNINRVLREENVLLKESIERTSSSQQGERPDINQICTTQQVSYDREFARALKVFYQSINVARGQFLKLRHYKPPEDDQMLRPFVHQQSQMLKDFGDLLESSLWKLKNDVALIVKQKKECLLHAE", "length": 958, "header": "tr|A0A3Q1MN62-1|A0A3Q1MN62_BOVIN Computationally mapped isoform of Kinesin-like protein OS=Bos taurus OX=9913 GN=KIF28 PE=3 SV=1 CANONICAL=A0AAA9T234-1" }, "locus": { "chromosome": "16", "start_pos": 30586904, "end_pos": 30514461, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073325.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073325.1" } ] } }, { "isoform_ac": "A0AAA9S589-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234/entry#A0AAA9S589-1", "sequence": { "sequence": "SARCNQGRVSVPCREKNSGSKCVISMHSRTTTIIQDPKNPGHTKTFTFDLAYWSHSGFQKDKDGVFISADRGSKFAGQKEVFHDLGRGILDSAWQGYNTTLLAYGQTGSGKSYSMIGFGANKGIIPNVCEELFQAIENRDKNQEYQVTFSMLEIYNEQVRDLLSRIKKPGGLKVREDQQLGFYVDGLQSVPCENYAQIERLMEQGAKIRTTASTNMNASSSRSHMVITIQFKQVFPDRGLTKQSSINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTNLGNVISALADAAMGKKVLHVPYRDSVLTKLLQSALGGNSRTTLIAAISPADICYEETLSTLRYAERYDYEYLLSIVVLKRAMSQPHFAISIFWVMRSLEDWEQWIGRNFALCAVLPRLVRIPSLFLLQEQQMIKTFPHLLNVNEDPQLTGVLKHFIQAGSCDAGKAASNAITLQGLGISEKHASFTNSGGKVTVTPYGKCKVIVNGVPITTKTKLQHLDRIILGSNSAYLYIGFPSERGSEDLSRFDYDFFQLERAAAEGVSTDKLGAVNSGDGKADPSVLAVFQDYVKLMPLVAEANQMSEELKKGLNMELKVKNLASSDSRGCDLQKEVTVKVTHQRTHQVWIWSKAKFINRKFLMEELYQRFLDGEDSQVAQEDDPFWDPVEVVHLGSAHIWLQSLAYCMKFEEQVEFLNCDGLEEAVLHIHIKPCSPTGQARGEEDVVTDPVDLLGKRMDFQIRLVQCLGTKWLKEDAERGVQMGYRIYDLPNTLYTKPVWKIVNPQIDETVQFTTLNASQEFLNYLQTNALIVDLWGLQEGCAELSCSRLDLMVTGEGHILVDTKKISTSTSNQIPELYLKLLKLEQETELLRNINRVLREENVLLKESIERTSSSQQGERPTRKITRMTAQGPLARDINQICTTQQVSYDREFARALKVFYQSINVARGQFLKLRHYKPPEDDQMLRPFVHQQSQMLKDFGDLLESSLWKLKNDVALIVKQKKECLLHAE", "length": 1005, "header": "tr|A0AAA9S589-1|A0AAA9T234_BOVIN Computationally mapped isoform of Kinesin-like protein 6 OS=Bos taurus OX=9913 GN=KIF28 PE=3 SV=1 CANONICAL=A0AAA9T234-1" }, "locus": { "chromosome": "16", "start_pos": 30586904, "end_pos": 30513687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079024.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079024.1" } ] } }, { "isoform_ac": "A0AAA9T234-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234/entry#A0AAA9T234-1", "sequence": { "sequence": "SARCNQGRVSVPCREKNSGSKCVISMHSRTTTIIQDPKNPGHTKTFTFDLAYWSHSGFQKDKDGVFISADRGSKFAGQKEVFHDLGRGILDSAWQGYNTTLLAYGQTGSGKSYSMIGFGANKGIIPNVCEELFQAIENRDKNQEYQVTFSMLEIYNEQVRDLLSRIKKPGGLKVREDQQLGFYVDGLQSVPCENYAQIERLMEQGAKIRTTASTNMNASSSRSHMVITIQFKQVFPDRGLTKQSSINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTNLGNVISALADAAMGKKVLHVPYRDSVLTKLLQSALGGNSRTTLIAAISPADICYEETLSTLRYAERYDYEYLLSIVVLKRAMSQPHFAISIFWVMRSLEDWEQWIGRNFALCAVLPRLVRIPSLFLLQEQQMIKTFPHLLNVNEDPQLTGVLKHFIQAGSCDAGKAASNAITLQGLGISEKHASFTNSGGKVTVTPYGKCKVIVNGVPITTKTKLQHLDRIILGSNSAYLYIGFPSERGSEDLSRFDYDFFQLERAAAEGVSTDKLGAVNSGDGKADPSVLAVFQDYVKLMPLVAEANQMSEELKKGLNMELKVKNLASSDSRGCDLQKEVTVKVTHQRTHQVWIWSKAKFINRKFLMEELYQRFLDGEDSQVAQEDDPFWDPVEVVHLGSAHIWLQSLAYCMKFEEQVEFLNCDGLEEAVLHIHIKPCSPTGQARGEEDVVTDPVDLLGKRMDFQIRLVQCLGTKWLKEDAERGVQMGYRIYDLPNTLYTKPVWKIVNPQIDETVQFTTLNASQEFLNYLQTNALIVDLWGLQEGCAELSCSRLDLMVTGEGHILVDTKKISTSTSNQIPELYLKLLKLEQETELLRNINRVLREENVLLKESIERTSSSQQGERPTGASITRMTAQGPLARDINQICTTQQVSYDREFARALKVFYQSINVARGQFLKLRHYKPPEDDQMLRPFVHQQSQMLKDFGDLLESSLWKLKNDVALIVKQKKECLLHAE", "length": 1006, "header": "tr|A0AAA9T234-1|A0AAA9T234_BOVIN Isoform 1 of Kinesin-like protein 6 OS=Bos taurus OX=9913 GN=KIF28 PE=3 SV=1 CANONICAL=A0AAA9T234-1" }, "locus": { "chromosome": "16", "start_pos": 30586904, "end_pos": 30513687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107614.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107614.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089716.1" } ] } }, { "isoform_ac": "A0AAA9TZ95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234/entry#A0AAA9TZ95-1", "sequence": { "sequence": "SARCNQGRVSVPCREKNSGSKCVISMHSRTTTIIQDPKNPGHTKTFTFDLAYWSHSGFQKDKDGVFISADRGSKFAGQKEVFHDLGRGILDSAWQGYNTTLLAYGQTGSGKSYSMIGFGANKGIIPNVCEELFQAIENRDKNQEYQVTFSMLEIYNEQVRDLLSRIKKPGGLKVREDQQLGFYVDGLQSVPCENYAQIERLMEQGAKIRTTASTNMNASSSRSHMVITIQFKQVFPDRGLTKQSSINLVDLAGSERQKSSGSEGDRLREGSRVNLSLTNLGNVISALADAAMGKKVLHVPYRDSVLTKLLQSALGGNSRTTLIAAISPADICYEETLSTLRYAERYDYEYLLSIVTHSCPFRISEKHASFTNSGGKVTVTPYGKCKVIVNGVPITTKTKLQHLDRIILGSNSAYLYIGFPSERGSEDLSRFDYDFFQLERAAAEGVSTDKLGAVNSGDGKADPSVLAVFQDYVKLMPLVAEANQMSEELKKGLNMELKVKNLASSDSRGCDLQKEVTVKVTHQRTHQVWIWSKAKFINRKFLMEELYQRFLDGEDSQVAQEDDPFWDPVEVVHLGSAHIWLQSLAYCMKFEEQVEFLNCDGLEEAVLHIHIKPCSPTGQARGEEDVVTDPVDLLGKRMDFQIRLVQCLGTKWLKEDAERGVQMGYRIYDLPNTLYTKPVWKIVNPQIDETVQFTTLNASQEFLNYLQTNALIVDLWGLQGTMLTSPFAWWPLARDINQICTTQQVSYDREFARALKVFYQSINVARGQFLKLRHYKPPEDDQMLRPFVHQQSQMLKDFGDLLESSLWKLKNDVALIVKQKKECLLHAE", "length": 828, "header": "tr|A0AAA9TZ95-1|A0AAA9TZ95_BOVIN Computationally mapped isoform of Kinesin-like protein OS=Bos taurus OX=9913 GN=KIF28 PE=3 SV=1 CANONICAL=A0AAA9T234-1" }, "locus": { "chromosome": "16", "start_pos": 30586904, "end_pos": 30513687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103593.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103593.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103640.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 897, "start_aa": "Thr", "end_pos": 897, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr897", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3YXS5-1", "protein_name": "Kinesin-like protein KIF28", "gene_name": "Kif28", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRVPVPRSDSVRVAVRVRPFSQREKNSGSQCVISMHSGNISIRDPKNEERVKTFTFDLTYWSHDGFQKDEDGVLIPSDPASKFAGQSDVFHDIGRGILDSAWRGYNATLLAYGQTGSGKSYSMIGFGTNKGLIPRVCEELFQAIEKQKENLEPQVMFSMLEIYNEQIRDLLSRTKAPGGLRVREDQQLGFFVEGLKWVPCENYAQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIQFKQVFLDTALTKRSSINMVDLAGSERQRSSGSEGDRLREGSRVNLSLTSLGNVISALADLAMGKKVLHIPYRDSVLTKLLQSALGGNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVINTCPLARASRAENALLLGFRGAGAAEHPACFWAEQQLGNQGTWAQLLEQARREWEEQYEALTQEQKMVRILPHLLNVNEDPQLTGVLKFFIHNGSCDVGRAASNAICLQGLGISDKHASFVNLDGKVTVAPHSKCKVIVNGVPVTGRTKLQHLDRIILGSNSAFLYVGFPSERGAEDLSRFDYDFFQLERAAAEGVSVATLGCVSPGDDQADPSILAVFQDYVKLMPLVVEANQMSEELKKGLTMELKVKNLASSDSRGYDLQKEVMVKVTKQGTHEVWIWSKAKFINRKFLMEELYQRFLESRDSHVAQEDDPFWDPLEVVHLGSAHVWLQPLAHCMMLEEQVEFLNCDGLEEAVLHIRITPCSPEGWAHGEEDMVIDPLELLGKRIDFQTHIVRCLGVKWLKEDGSRGIQMGYGIYDLPNTLYTKPVWKSVNPRIEETVHFAALGASREFLDYLLTNALIVDLWGLQEGCAPLGVSQLDVLLTGEGHIMVDTKTFSSVKDVSQITSNQVPELYQKLLKLEQETELLRDVNRALRGENVFLKASLENAGSAPQAQKLDNPEGATRTAAREAKQVCAQQASSDAQLARALKVFYQGMGVARGQLLRLRRCRPPEDDQMLRPFVHQQSQMLKDLEDLLESSLHKLKADVAFIVKKRKEYLLPSQQ", "length": 1028 }, "evidence": [ { "id": "A0AAA9T234", "url": "https://omabrowser.org/oma/group/A0AAA9T234/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F8WLE0-1", "protein_name": "Kinesin-like protein KIF28", "gene_name": "Kif28", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDCEKMGKLPVPRTDSVRVAVRVRPFSQREKNSGSQCVISMHARSITIRDPKDAELVKTFTFDLAYWSHDGFQKDEDGVLIPSDPTSKFAGQSDVFHDIGRGILDSAWQGYNATLLAYGQTGSGKSYSMIGYGANKGIIPRVCEELFQAIEKQKESLEAQVMFSMLEIYNEQIRDLLSRTKAPGGLRVREDQRLGFFVEGLKWVPCEDSVQIEKLVEQGSKIRMTASTNMNASSSRSHMLIAIRFKQVFLDTALTKQSSINMVDLAGSERQRSSGSEGDRLREGSRVNLSLTNLGNVISALADLAMGKKVLHIPYRDSVLTKLLQSALGGNSRTTLIAALSPADICYEETLSTLRYAERAKKVRNRAVINTCPLVRASRAENALLLGFGGAGAAEHSACFWAEQQLGTWGTWAQLLEQARREWEQQYMALAQEQQMVKILPHLLNVNEDPQLTGVLKFFIHNGSCEVGRAASNAICLQSLGISDKHASFTNMDGKVTVAPHITGKVIVNGVPVSSRTKLQHLDRIILGSNSAFLYIGFPSERGAEDLGRFDYDFFQMERAAAEGVSVDMLGTASPGDDQADPSILAVFQDYIKLMPLVVEANQMSEELKKGLKMELKVKNLASSDSRGCDLQKEVMVKVTKQGTHEVWIWSKAKFINRKFLMEELYQRFLESRDSHVAQEDDPFWDPVEVLHLGSAHVWLQSLAHRMMLEEQVEFLNCEGLEEAVLHIQITPCSPEGWAHGEEDTVIDPLELLGKRIDFQIHIVQCLGVKWLKEDATRGIQLGYKVYDLPNTLYTKPVWQSVNPRVEESVHFAALGVSREFLNYLLTNALVVDLWGLQEGCAHLGVSQPDVLFTGEGYIMVDTKTFSSVKDITSNQVPELYQKLLKLEQETELLRDINRALRGENVYLKAALENAGSAPQGERRYHKPDNPEGATVTAAGEAKQMCAQRASSDSQLARALKVFYGGMSVARGQLLRLRQCRPPEDDQMLRPFVHQQSQMLKDLEDLLESSLQKLKSDVAFIVKKKKEYLLPRGR", "length": 1034 }, "evidence": [ { "id": "A0AAA9T234", "url": "https://omabrowser.org/oma/group/A0AAA9T234/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "kinesin complex", "id": "GO:0005871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule-based movement", "id": "GO:0007018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" }, { "name": "vesicle transport along microtubule", "id": "GO:0047496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T234", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 791, "end_pos": 793, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T234" }, { "id": "PS50067", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50067" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kinesin motor", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 349, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 897 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 217, "end_pos": 219 }, { "start_pos": 274, "end_pos": 276 }, { "start_pos": 791, "end_pos": 793 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4C9-1", "uniprot_ac": "A0AAA9T4C9", "uniprot_id": "A0AAA9T4C9_BOVIN", "mass": { "chemical_mass": 76023.0, "monoisotopic_mass": 76023.0 }, "refseq": {}, "gene_names": [ { "name": "SLC44A1", "type": "recommended", "evidence": [ { "id": "A0AAA9T4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ] } ], "protein_names": [ { "name": "Choline transporter-like protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Choline transporter.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S7S9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S9#function" }, { "database": "UniProtKB", "id": "RU368066", "url": "https://www.uniprot.org/uniprotkb/RU368066#function" }, { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC44A1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9", "locus": { "chromosome": "8", "start_pos": 95266177, "end_pos": 95034654, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007163", "url": "https://www.ensembl.org/id/ENSBTAG00000007163" } ] } } ], "crossref": [ { "id": "A0AAA9T4C9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4C9", "database": "AlphaFoldDB", "categories": [] }, { "id": "538887", "url": "https://www.ncbi.nlm.nih.gov/gene/538887", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12385", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12385:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12385:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04515", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04515", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S7S9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCCSSASSAAQLKNWDCIMITNRIVLKIKAVDLEQVKSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSVATGAAARLVSGYDSYGNICGQKNAELEAIPNSGMDHTHRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTISDVQKFAEINGSALCSYDLKPSEYASSKAKGLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRILVWILTFLLILGSLAGTGVLWWLYAKQRKSPKETVIPDQPQVAEANLRALLIYAISATVFTVILFLVMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTAGSAVQNEQGFVEFKMSGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVAAINTVGDFMLFLGKVLIVCSTGLAGVMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAVDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADARELKPMASGASSA", "length": 682, "header": "tr|A0AAA9T4C9-1|A0AAA9T4C9_BOVIN Isoform 1 of Choline transporter-like protein OS=Bos taurus OX=9913 GN=SLC44A1 PE=3 SV=1 CANONICAL=A0AAA9T4C9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9/entry#A0AAA9S7S9-1", "sequence": { "sequence": "MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSVATGAAARLVSGYDSYGNICGQKNAELEAIPNSGMDHTHRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTISDVQKFAEINGSALCSYDLKPSEYASSKAKGLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRILVWILTFLLILGSLAGTGVLWWLYAKQRKSPKETVIPDQPQVAEANLRALLIYAISATVFTVILFLVMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTAGSAVQNEQGFVEFKMSGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVAAINTVGDFMLFLGKVLIVCSTGLAGVMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAVDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADARELKPMLRRR", "length": 653, "header": "tr|A0AAA9S7S9-1|A0AAA9T4C9_BOVIN Computationally mapped isoform of Choline transporter-like protein OS=Bos taurus OX=9913 GN=SLC44A1 PE=3 SV=1 CANONICAL=A0AAA9T4C9-1" }, "locus": { "chromosome": "8", "start_pos": 95265173, "end_pos": 95034853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112575.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112575.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079991.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079991.1" } ] } }, { "isoform_ac": "A0AAA9T4C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9/entry#A0AAA9T4C9-1", "sequence": { "sequence": "MGCCSSASSAAQLKNWDCIMITNRIVLKIKAVDLEQVKSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSVATGAAARLVSGYDSYGNICGQKNAELEAIPNSGMDHTHRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTISDVQKFAEINGSALCSYDLKPSEYASSKAKGLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRILVWILTFLLILGSLAGTGVLWWLYAKQRKSPKETVIPDQPQVAEANLRALLIYAISATVFTVILFLVMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTAGSAVQNEQGFVEFKMSGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVAAINTVGDFMLFLGKVLIVCSTGLAGVMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAVDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADARELKPMASGASSA", "length": 682, "header": "tr|A0AAA9T4C9-1|A0AAA9T4C9_BOVIN Isoform 1 of Choline transporter-like protein OS=Bos taurus OX=9913 GN=SLC44A1 PE=3 SV=1 CANONICAL=A0AAA9T4C9-1" }, "locus": { "chromosome": "8", "start_pos": 95213933, "end_pos": 95034853, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103341.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103341.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091511.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "organic cation transport", "id": "GO:0015695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015695", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" }, { "name": "choline transmembrane transporter activity", "id": "GO:0015220", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015220", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" }, { "name": "ethanolamine transmembrane transporter activity", "id": "GO:0034228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4C9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 161, "end_pos": 163 }, { "start_pos": 205, "end_pos": 207 }, { "start_pos": 532, "end_pos": 534 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2N7-1", "uniprot_ac": "A0AAA9T2N7", "uniprot_id": "A0AAA9T2N7_BOVIN", "mass": { "chemical_mass": 78271.0, "monoisotopic_mass": 78271.0 }, "refseq": {}, "gene_names": [ { "name": "CDT1", "type": "recommended", "evidence": [ { "id": "A0AAA9T2N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ] } ], "protein_names": [ { "name": "DNA replication factor Cdt1", "type": "recommended", "evidence": [ { "id": "A0AAA9T2N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#names_and_taxonomy" } ] }, { "name": "Double parked homolog", "type": "synonym", 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DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LIW5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIW5#function" }, { "database": "UniProtKB", "id": "ARBA00060007", "url": "https://www.uniprot.org/uniprotkb/ARBA00060007#function" }, { "database": "UniProtKB", "id": "F1MCJ1", "url": "https://www.uniprot.org/uniprotkb/F1MCJ1#function" }, { "database": "UniProtKB", "id": "A0AAA9S8C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C7#function" }, { "database": "UniProtKB", "id": "A0AAA9SDY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY8#function" }, { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7#function" }, { "database": "UniProtKB", "id": "A0AAA9U2P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7", "locus": { "chromosome": "18", "start_pos": 14020966, "end_pos": 14008461, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000638", "url": "https://www.ensembl.org/id/ENSBTAG00000000638" } ] } } ], "crossref": [ { "id": "A0AAA9T2N7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2N7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000638", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000638", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08674", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08674", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08767", "url": 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Classification" ] }, { "id": "F1MCJ1", "url": "https://www.orthodb.org/?gene=F1MCJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28637", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28637", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28637:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28637:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-68867", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68949", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-68962", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69052", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69052", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LIW5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LIW5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U2P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCJ1", "url": "https://www.uniprot.org/uniprotkb/F1MCJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCJ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MCJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLQLLASGVPEPQQGLRGSPTLKKVTQPQTSSSASLSSHVHYNHSGSTGVHGFPFGNARSTEAPPGLLTFPYSNAYEAHTVGPGSFPRLRMRMQPKPSSWARDGPNRKPRHMASWAPGERPTPPIHFGDVDRFPYHPRTAVCWRARGSSRICCCCCC", "length": 708, "header": "tr|A0AAA9T2N7-1|A0AAA9T2N7_BOVIN Isoform 1 of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=2 CANONICAL=A0AAA9T2N7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#A0A3Q1LIW5-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLQLLASGVPEPQQGLRGSPTLKKVTQPQTRWLGAGVTRTAGGRRRAQPPASPCPSVRSAPPGLHTPAPQPAAGPAAHRLRTWFLVGEERDHGDSP", "length": 647, "header": "tr|A0A3Q1LIW5-1|A0A3Q1LIW5_BOVIN Computationally mapped isoform of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=2 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14013464, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067336.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067336.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059144.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059144.2" } ] } }, { "isoform_ac": "A0AAA9S8C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#A0AAA9S8C7-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLRQLLASGVPEPQQGLRGSPTLKKVTQPQTRWMPRCGTTCLISTWPGSSSAPEAGTGDTALRRPGINMACLSLKGTVC", "length": 630, "header": "tr|A0AAA9S8C7-1|A0AAA9T2N7_BOVIN Computationally mapped isoform of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=1 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14017485, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131358.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131358.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080182.1" } ] } }, { "isoform_ac": "A0AAA9SDY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#A0AAA9SDY8-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLRQLLASGVPEPQQGLRGSPTLKKVTQPQTR", "length": 583, "header": "tr|A0AAA9SDY8-1|A0AAA9T2N7_BOVIN Computationally mapped isoform of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=1 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14015374, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080593.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080593.1" } ] } }, { "isoform_ac": "A0AAA9T2N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#A0AAA9T2N7-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLQLLASGVPEPQQGLRGSPTLKKVTQPQTSSSASLSSHVHYNHSGSTGVHGFPFGNARSTEAPPGLLTFPYSNAYEAHTVGPGSFPRLRMRMQPKPSSWARDGPNRKPRHMASWAPGERPTPPIHFGDVDRFPYHPRTAVCWRARGSSRICCCCCC", "length": 708, "header": "tr|A0AAA9T2N7-1|A0AAA9T2N7_BOVIN Isoform 1 of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=2 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14014644, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123294.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123294.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089916.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089916.2" } ] } }, { "isoform_ac": "A0AAA9U2P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#A0AAA9U2P2-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQRECTRPQAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETL", "length": 526, "header": "tr|A0AAA9U2P2-1|A0AAA9U2P2_BOVIN Computationally mapped isoform of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=1 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14012512, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103125.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103125.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103883.1" } ] } }, { "isoform_ac": "F1MCJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7/entry#F1MCJ1-1", "sequence": { "sequence": "MAQRRLTDFFARRRPGGSATLPRAKPAWRTPSPAKSAPCAAAPGPGSSRKRTRPPAEPTRDERVPPARKRLKLSADAVSGPSSPAARGSPEHPSPQSKETKKAARSAGGRPCLAAQENKVPSKVTLSELKSCLQRAQELGARFQELKASAQKDAGEPSAPEDEGRLEEPCGEQMPAYQRFHALAQPGLPGLVLPYKYQVLSEMFRSMDTIVGMLYNRSETVTFAKVKQGVQDMMRKRFEERNVGQIKTVYPGSYHFRQERFVPTFKDGIKRSDYQLTIEPLLDQQAGSAAPQLTASRLLQRRQVFSQNLVARVREHHRAFLASLNPPMEVPEDQLTRWHPRFNVDGVPDIEPAELPQPPAVEKLTTAQEVLARARSLMSPRMEKALSDLAQRTAEPSSPRSPSLAQPATPPATPPAAPPSALKGVSQALLERIRAKEAQKQLAQMTRRPEQEQRLQRLERLPELARVLRGVFVSERKPALTMEVACARMVGSYRAAMSPGEMEKHLQLLSELLPDWLSLHRIRTDTYVKLDKAADLAGVMEQLAHLARAEETLQLLASGVPEPQQGLRGSPTLKKVTQPQTRTKLLTSTL", "length": 590, "header": "tr|F1MCJ1-1|F1MCJ1_BOVIN Computationally mapped isoform of DNA replication factor Cdt1 OS=Bos taurus OX=9913 GN=CDT1 PE=3 SV=4 CANONICAL=A0AAA9T2N7-1" }, "locus": { "chromosome": "18", "start_pos": 14020864, "end_pos": 14008645, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054406.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054406.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048486.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048486.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 409, "start_aa": "Thr", "end_pos": 409, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr409", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 413, "start_aa": "Thr", "end_pos": 413, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr413", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 673, "start_aa": "Thr", "end_pos": 673, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr673", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-68867", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68867", "resource": "Reactome", "description": "Assembly of the pre-replicative complex" }, { "id": "R-BTA-68949", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68949", "resource": "Reactome", "description": "Orc1 removal from chromatin" }, { "id": "R-BTA-68962", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-68962", "resource": "Reactome", "description": "Activation of the pre-replicative complex" }, { "id": "R-BTA-69052", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69052", "resource": "Reactome", "description": "Switching of origins to a post-replicative state" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "DNA replication checkpoint signaling", "id": "GO:0000076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "regulation of DNA-templated DNA replication initiation", "id": "GO:0030174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030174", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "DNA replication preinitiation complex assembly", "id": "GO:0071163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "attachment of mitotic spindle microtubules to kinetochore", "id": "GO:0051315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "response to sorbitol", "id": "GO:0072708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072708", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated DNA replication", "id": "GO:2000104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "mitotic DNA replication initiation", "id": "GO:1902975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "mitotic pre-replicative complex assembly", "id": "GO:1902985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902985", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N7" } ], "pmid": "" }, { "name": "DNA polymerase binding", "id": "GO:0070182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070182", "evidence": [ { "database": "UniProtKB", 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"MSNLKMKEAALIYLDRSGGLQKFIDDCKYYNDSKQSYAVYRFNVLINPSDIVELDAELGNHILHQPLKAAQVFQSVCYIAVKTLSLIGQLQTETQINIVLKLTHLPPLPSYYLDLCEFPRDYTSQRFYTMQGIVIAMTTVTKYTQGARFLCSDEACPLSKGFQYIRVHVPGATESATVRNDFLCNLCSSSLQEDRKFRVLGDKQIVEIITAESLHAFQGYCNNQPFRFQSLTVFLRDESVNKMNIGNEYKVIGIPTCVKTSQTAVCVEANSITFCIPKVPSGISDNFRCLLSLTSSSCWKFTAILANIFASQIVPPGTYNLLKLCLLMSLVQTSDRNKELENFLDILIVTSDTLLIDRLLNFSISLVPRGIRHSVSTEIFPTVSRNKYGTGAVSIQAGSALLAKGGICFIGDLASHKKDKLEQLQSAVESRSITVYISGKKFGDDVDQQMTFPVQCSFWSFLDMDSPSRRNIQKTNMLIGQMDCSLIPANLVEAFALLINCSESSPCHPLLPTVQHTLKKAIDPEGLLYLASKQFTTEDFEKLLAFAKNLNVEFSLEAERMIHGYYLASRRIRTDSICGSKLSASALKYLVSLSEAHARLNLRNKVLKEDVLIAALLFETSLTLKYGAAVFCVAPNAVFPFEQYNEDYLEQRDVYLTECQQQLQQFIATYGPGTAIFASDE", "length": 681, "header": "tr|A0AAA9T4P9-1|A0AAA9T4P9_BOVIN Isoform 1 of Minichromosome maintenance domain-containing protein 2 OS=Bos taurus OX=9913 GN=MCMDC2 PE=3 SV=1 CANONICAL=A0AAA9T4P9-1" }, "locus": { "chromosome": "14", "start_pos": 31102413, "end_pos": 31063678, "strand": "-", "evidence": [ { "database": 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"https://www.ebi.ac.uk/interpro/entry/IPR002404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336967", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336967", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FQIFRRC", "url": "https://omabrowser.org/oma/group/FQIFRRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3N3X9", "url": "https://www.orthodb.org/?gene=G3N3X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697712", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697712", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T243", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T243-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8S0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8S0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8S0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3X9", "url": "https://www.uniprot.org/uniprotkb/G3N3X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3X9-1", "url": "https://www.uniprot.org/uniprotkb/G3N3X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGHGFGPSKMSRAQTFPSYASEQSEETQPALSRSSSYGFSYSSSLIQ", "length": 331, "header": "tr|A0AAA9T243-1|A0AAA9T243_BOVIN Isoform 1 of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=1 CANONICAL=A0AAA9T243-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#A0AAA9S9Q4-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGFLKNAIFYGYDYAIQK", "length": 302, "header": "tr|A0AAA9S9Q4-1|A0AAA9T243_BOVIN Computationally mapped isoform of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=1 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7428624, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117942.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117942.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080146.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080146.1" } ] } }, { "isoform_ac": "A0AAA9SN33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#A0AAA9SN33-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGLLTSPHHPWDAVLPVQPACRFAKEKQLRDLT", "length": 317, "header": "tr|A0AAA9SN33-1|A0AAA9T243_BOVIN Computationally mapped isoform of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=2 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7437312, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124214.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124214.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085302.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085302.2" } ] } }, { "isoform_ac": "A0AAA9T243-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#A0AAA9T243-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGHGFGPSKMSRAQTFPSYASEQSEETQPALSRSSSYGFSYSSSLIQ", "length": 331, "header": "tr|A0AAA9T243-1|A0AAA9T243_BOVIN Isoform 1 of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=1 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7406098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092057.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092057.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092866.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092866.1" } ] } }, { "isoform_ac": "A0AAA9T8S0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#A0AAA9T8S0-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGDRELAAIRPPAVGLFQTRTPKATHLSLLHF", "length": 316, "header": "tr|A0AAA9T8S0-1|A0AAA9T8S0_BOVIN Computationally mapped isoform of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=1 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7419340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093218.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093218.1" } ] } }, { "isoform_ac": "A0AAA9TNG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#A0AAA9TNG8-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGVLCIFLIEVVCQVCC", "length": 301, "header": "tr|A0AAA9TNG8-1|A0AAA9TNG8_BOVIN Computationally mapped isoform of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=1 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7452230, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100076.1" } ] } }, { "isoform_ac": "G3N3X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243/entry#G3N3X9-1", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQSSVGEIYSLQGPDMTEGLCRGHSVKDMNW", "length": 304, "header": "tr|G3N3X9-1|G3N3X9_BOVIN Computationally mapped isoform of Docking protein 6 OS=Bos taurus OX=9913 GN=DOK6 PE=3 SV=2 CANONICAL=A0AAA9T243-1" }, "locus": { "chromosome": "24", "start_pos": 7815350, "end_pos": 7437265, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064953.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064953.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056642.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056642.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336967", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336967", "resource": "KEGG Pathway" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X4D3-1", "protein_name": "Docking protein 6", "gene_name": "DOK6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMMEMEQKARLQTSLSEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHSLGSTKVSRAQTFPSYPAEQGEEHQQSLSLASSYTFSYGSGLVQ", "length": 331 }, "evidence": [ { "id": "A0AAA9T243", "url": "https://omabrowser.org/oma/group/A0AAA9T243/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M038-1", "protein_name": "Docking protein 6", "gene_name": "Dok6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQPPLSRSSSYGFSYSSSLIQ", "length": 331 }, "evidence": [ { "id": "A0AAA9T243", "url": "https://omabrowser.org/oma/group/A0AAA9T243/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2MHE5-1", "protein_name": "Docking protein 6", "gene_name": "Dok6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQPPLSRSSSYGFSYSSSLIQ", "length": 331 }, "evidence": [ { "id": "A0AAA9T243", "url": "https://omabrowser.org/oma/group/A0AAA9T243/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PKX4-1", "protein_name": "Docking protein 6", "gene_name": "DOK6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ", "length": 331 }, "evidence": [ { "id": "A0AAA9T243", "url": "https://omabrowser.org/oma/group/A0AAA9T243/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T243", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 67, "end_pos": 69, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T243" }, { "id": "PS51064", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRS-type PTB", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 237, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 67, "end_pos": 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"database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CWAAIHA", "url": "https://omabrowser.org/oma/group/CWAAIHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12566", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12566", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12566:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12566:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010818081", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010818081", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL3", "url": "https://www.uniprot.org/uniprotkb/E1BGL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGL3-1", "url": "https://www.uniprot.org/uniprotkb/E1BGL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDYGFALQLASSGGTGFSQLKHPPAPASSINEHTGNNAFLFFPISAAQTMQDDLLMDKSKTQPQPQQQRQQQQQPQPEPSTAEAPSTPLSSETPKPEDSSAVPALSPAAAPPAPNGPDKMQMESPLLPGLGFHQPPQQPPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPAQPAQPPQAQPSQQRRSPASPSQAPYAQRGATAAYGHQPIMTSKPSSSSAAAAVAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGRMGINFHHPGTDNIMALNSRSSLFPFEDAFLDDSHGDQSLSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 733, "header": "tr|A0AAA9T4F8-1|A0AAA9T4F8_BOVIN Isoform 1 of Cytoplasmic polyadenylation element binding protein 3 OS=Bos taurus OX=9913 GN=CPEB3 PE=3 SV=1 CANONICAL=A0AAA9T4F8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8/entry#A0AAA9SCS5-1", "sequence": { "sequence": "MGDYGFALQLASSGGTGFSQLKHPPAPASSINEHTGNNAFLFFPISAAQTMQDDLLMDKSKTQPQPQQQRQQQQQPQPEPSTAEAPSTPLSSETPKPEDSSAVPALSPAAAPPAPNGPDKMQMESPLLPGLGFHQPPQQPPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPAQPAQPPQAQPSQQRRSPASPSQAPYAQRGATAAYGHQPIMTSKPSSSSAAAAVAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGRMGINFHHPGTDNIMALNSRSSLFPFEDAFLDDSHGDQSLSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRQGSPPSRPWTSTSCHISSGIKLETKCTINVMYLNHPKSISLTSVHGTINFYKTGPRCQKRWRPLSYRSGLLP", "length": 730, "header": "tr|A0AAA9SCS5-1|A0AAA9T4F8_BOVIN Computationally mapped isoform of Cytoplasmic polyadenylation element binding protein 3 OS=Bos taurus OX=9913 GN=CPEB3 PE=3 SV=1 CANONICAL=A0AAA9T4F8-1" }, "locus": { "chromosome": "26", "start_pos": 13728498, "end_pos": 13601855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083926.1" } ] } }, { "isoform_ac": "A0AAA9SVW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8/entry#A0AAA9SVW4-1", "sequence": { "sequence": "MQDDLLMDKSKTQPQPQQQRQQQQQPQPEPSTAEAPSTPLSSETPKPEDSSAVPALSPAAAPPAPNGPDKMQMESPLLPGLGFHQPPQQPPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPAQPAQPPQAQPSQQRRSPASPSQAPYAQRGATAAYGHQPIMTSKPSSSSAAAAVAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNNAFLDDSHGDQSLSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 697, "header": "tr|A0AAA9SVW4-1|A0AAA9T4F8_BOVIN Computationally mapped isoform of Cytoplasmic polyadenylation element binding protein 3 OS=Bos taurus OX=9913 GN=CPEB3 PE=3 SV=1 CANONICAL=A0AAA9T4F8-1" }, "locus": { "chromosome": "26", "start_pos": 13728348, "end_pos": 13581472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099493.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099493.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090627.1" } ] } }, { "isoform_ac": "A0AAA9T4F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8/entry#A0AAA9T4F8-1", "sequence": { "sequence": "MGDYGFALQLASSGGTGFSQLKHPPAPASSINEHTGNNAFLFFPISAAQTMQDDLLMDKSKTQPQPQQQRQQQQQPQPEPSTAEAPSTPLSSETPKPEDSSAVPALSPAAAPPAPNGPDKMQMESPLLPGLGFHQPPQQPPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPAQPAQPPQAQPSQQRRSPASPSQAPYAQRGATAAYGHQPIMTSKPSSSSAAAAVAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGRMGINFHHPGTDNIMALNSRSSLFPFEDAFLDDSHGDQSLSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 733, "header": "tr|A0AAA9T4F8-1|A0AAA9T4F8_BOVIN Isoform 1 of Cytoplasmic polyadenylation element binding protein 3 OS=Bos taurus OX=9913 GN=CPEB3 PE=3 SV=1 CANONICAL=A0AAA9T4F8-1" }, "locus": { "chromosome": "26", "start_pos": 13728498, "end_pos": 13581472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092691.1" } ] } }, { "isoform_ac": "E1BGL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8/entry#E1BGL3-1", "sequence": { "sequence": "MQDDLLMDKSKTQPQPQQQRQQQQQPQPEPSTAEAPSTPLSSETPKPEDSSAVPALSPAAAPPAPNGPDKMQMESPLLPGLGFHQPPQQPPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPAQPAQPPQAQPSQQRRSPASPSQAPYAQRGATAAYGHQPIMTSKPSSSSAAAAVAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGRMGINFHHPGTDNIMALNSRSSLFPFEDAFLDDSHGDQSLSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 683, "header": "tr|E1BGL3-1|E1BGL3_BOVIN Computationally mapped isoform of Cytoplasmic polyadenylation element binding protein 3 OS=Bos taurus OX=9913 GN=CPEB3 PE=3 SV=4 CANONICAL=A0AAA9T4F8-1" }, "locus": { "chromosome": "26", "start_pos": 13728348, "end_pos": 13581472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013178.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013178.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013178.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013178.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537016", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537016", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AD99-1", "protein_name": "Cytoplasmic polyadenylation element binding protein 3", "gene_name": "Cpeb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTLLTVVKVLFQSGHIINPKEEINTIHFFSILSIFKNWTLKAAQTMQDDLLMDKSKTQPQSQQQQQQQQQQQQQQQQQQQQRQQQQQQQQQLQPEPGAAEAPSTPLSSETPKPEDSSAVPALSPASAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPPQPAQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMTSKPSSSSAAAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRQVPFRWS", "length": 779 }, "evidence": [ { "id": "A0AAA9T4F8", "url": "https://omabrowser.org/oma/group/A0AAA9T4F8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TN99-1", "protein_name": "Cytoplasmic polyadenylation element-binding protein 3", "gene_name": "Cpeb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQDDLLMDKSKTQPQSQQQQRQQQQQQQQLQPEPGAAEAPSTPLSSEIPKPEDSSAVPALSPASAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPTAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPPQPAQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPNSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 716 }, "evidence": [ { "id": "A0AAA9T4F8", "url": "https://omabrowser.org/oma/group/A0AAA9T4F8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NE35-1", "protein_name": "Cytoplasmic polyadenylation element-binding protein 3", "gene_name": "CPEB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQDDLLMDKSKTQPQPQQQQRQQQQPQPESSVSEAPSTPLSSETPKPEENSAVPALSPAAAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPAPQPAQPAQPPQAQPPQQRRSPASPSQAPYAQRSAAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNNAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS", "length": 698 }, "evidence": [ { "id": "A0AAA9T4F8", "url": "https://omabrowser.org/oma/group/A0AAA9T4F8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "translation regulator activity", "id": "GO:0045182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045182", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "translation factor activity, RNA binding", "id": "GO:0008135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008135", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "mRNA regulatory element binding translation repressor activity", "id": "GO:0000900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "CCR4-NOT complex", "id": "GO:0030014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030014", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "id": "GO:0060213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060213", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "id": "GO:1900153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900153", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "3'-UTR-mediated mRNA destabilization", "id": "GO:0061158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "long-term memory", "id": "GO:0007616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4F8" } ], "pmid": "" }, { "name": "negative regulation of cytoplasmic translation", "id": "GO:2000766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000766", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4F8", "url": 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"url": "https://www.ensembl.org/id/ENSBTAP00000093046.1" } ] } }, { "isoform_ac": "E1B7T3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520/entry#E1B7T3-1", "sequence": { "sequence": "MTASVEPRGRRPGVGVGVVVTSGRHPRCVLLGKRKGSFGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNVRFASVVNSFIEKENYHYVTILMKGEVDLTHDSEPKNVEPEKNESWEWVPWEEFPPLDQLFWGLRCLKEQGYDPFKEDLDHLVGYKGSHLESHCCCLRSPLT", "length": 176, "header": "tr|E1B7T3-1|E1B7T3_BOVIN Computationally mapped isoform of Nucleotide triphosphate diphosphatase NUDT15 OS=Bos taurus OX=9913 GN=NUDT15 PE=3 SV=2 CANONICAL=A0AAA9T520-1" }, "locus": { "chromosome": "12", "start_pos": 17897301, "end_pos": 17883601, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025978.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025978.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025978.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025978.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], 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"https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "purine deoxyribonucleoside triphosphate catabolic process", "id": "GO:0009217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009217", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "dGTP catabolic process", "id": "GO:0006203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "DNA protection", "id": "GO:0042262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "xenobiotic catabolic process", "id": "GO:0042178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "regulation of proteasomal protein catabolic process", "id": "GO:0061136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T520", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23996", "name": "", "equation": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P15396-1", "F1MNS5-1", "A0AAA9T520-1" ], "evidence": [ { "id": "23996", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23996" } ] }, { "id": "28362", "name": "", "equation": "dGTP + H2O = dGMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "28362", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/28362" } ] }, { "id": "44644", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "44644", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44644" } ] }, { "id": "47944", "name": "", "equation": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DI5-1", "A0AAA9T520-1" ], "evidence": [ { "id": "47944", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47944" } ] }, { "id": "48128", "name": "", "equation": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58DI5-1", "A0AAA9T520-1" ], "evidence": [ { "id": "48128", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48128" } ] }, { "id": "67592", "name": "", "equation": "a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZFU3-1", "A0A3Q1M899-1", "A1A4Q9-1", "Q29RJ1-1", "A0AAA9T520-1" ], "evidence": [ { "id": "67592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67592" } ] }, { "id": "70503", "name": "", "equation": "isopentenyl diphosphate + H2O = isopentenyl phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "70503", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70503" } ] }, { "id": "70507", "name": "", "equation": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "70507", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70507" } ] }, { "id": "R-BTA-2395869", "name": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "R-BTA-2395869", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2395869" } ] }, { "id": "R-BTA-2395876", "name": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9731300" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "R-BTA-2395876", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2395876" } ] }, { "id": "R-BTA-9750555", "name": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9749032" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9T520-1" ], "evidence": [ { "id": "R-BTA-9750555", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9750555" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9731300", "participant_name": "8-oxo-dGDP(3-) [cytosol]", "crossref": [ { "id": "63715", "database": "ChEBI", "url": "" }, { "id": "ZINC000058638349", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-9749032", "participant_name": "6TdGTP [cytosol]", "crossref": [ { "id": "180691", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M899", "gene_name": "NUDT19", "activity": [ { "ec_number": "3.6.1.77", "activity": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1M899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M899" } ] }, { "ec_number": "3.6.1.77", "activity": "", "evidence": [ { "id": "A0A3Q1M899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M899" } ] } ] }, { "uniprot_ac": "A0AAA9T520", "gene_name": "NUDT15", "activity": [ { "ec_number": "3.6.1.9", "activity": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.68", "activity": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.76", "activity": "dimethylallyl diphosphate + H2O = dimethylallyl phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.76", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.9", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] }, { "ec_number": "3.6.1.68", "activity": "", "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" } ] } ] }, { "uniprot_ac": "A0AAF6ZFU3", "gene_name": "NUDT2", "activity": [ { "ec_number": "3.6.1.17", "activity": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+).", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ] }, { "ec_number": "3.6.1.17", "activity": "", "evidence": [ { "id": "A0AAF6ZFU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZFU3" } ] } ] }, { "uniprot_ac": "A1A4Q9", "gene_name": "NUDT16", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.64", "activity": "dIDP + H2O = dIMP + phosphate + H(+).", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] }, { "ec_number": "3.6.1.62", "activity": "", "evidence": [ { "id": "A1A4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4Q9" } ] } ] }, { "uniprot_ac": "F1MNS5", "gene_name": "ENPP1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "F1MNS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNS5" } ] }, { "ec_number": "3.6.1.9", "activity": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "F1MNS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNS5" } ] }, { "ec_number": "3.1.4.1", "activity": "", "evidence": [ { "id": "F1MNS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNS5" } ] }, { "ec_number": "3.6.1.9", "activity": "", "evidence": [ { "id": "F1MNS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNS5" } ] } ] }, { "uniprot_ac": "P15396", "gene_name": "ENPP3", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.6.1.9", "activity": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.1.4.1", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] }, { "ec_number": "3.6.1.9", "activity": "", "evidence": [ { "id": "P15396", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15396" } ] } ] }, { "uniprot_ac": "Q29RJ1", "gene_name": "NUDT2", "activity": [ { "ec_number": "3.6.1.17", "activity": "P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+).", "evidence": [ { "id": "Q29RJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ1" } ] }, { "ec_number": "3.6.1.17", "activity": "", "evidence": [ { "id": "Q29RJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RJ1" } ] } ] }, { "uniprot_ac": "Q58DI5", "gene_name": "PLPP6", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q58DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI5" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q58DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI5" } ] }, { "ec_number": "3.6.1.68", "activity": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+).", "evidence": [ { "id": "Q58DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI5" } ] }, { "ec_number": "3.6.1.68", "activity": "", "evidence": [ { "id": "Q58DI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DI5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T520" }, { "id": "PS51462", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51462" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nudix hydrolase", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 145, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.6.1.9", "ec_name": "dTTP + H2O = dTMP + diphosphate + H(+).", "evidence": [ { "id": "3.6.1.9", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9" }, { "id": "3.6.1.9", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.9" } ] }, { "ec_number": "3.6.1.68", "ec_name": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+).", "evidence": [ { "id": "3.6.1.68", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68" }, { "id": "3.6.1.68", "database": 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}, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3T4-1", "uniprot_ac": "A0AAA9T3T4", "uniprot_id": "A0AAA9T3T4_BOVIN", "mass": { "chemical_mass": 119536.0, "monoisotopic_mass": 119536.0 }, "refseq": {}, "gene_names": [ { "name": "UNC45A", "type": "recommended", "evidence": [ { "id": "A0AAA9T3T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4" } ] } ], "protein_names": [ { "name": "Protein unc-45 homolog A", "type": "recommended", "evidence": [ { "id": "A0AAA9T3T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3T4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UNC45A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4", "locus": { "chromosome": "21", "start_pos": 21714626, "end_pos": 21731139, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018639", "url": "https://www.ensembl.org/id/ENSBTAG00000018639" } ] } } ], "crossref": [ { "id": "A0AAA9T3T4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3T4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018639", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535692", "url": "https://www.ncbi.nlm.nih.gov/gene/535692", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LDQKHED", "url": "https://omabrowser.org/oma/group/LDQKHED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F6PRQ6", "url": "https://www.orthodb.org/?gene=F6PRQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45994:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45994:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJR8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3T4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRQ6", "url": "https://www.uniprot.org/uniprotkb/F6PRQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRQ6-1", "url": "https://www.uniprot.org/uniprotkb/F6PRQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFQRRSGSLLTGLSVGLLLFFSWMMPAQPASLSALAHHPHLCQTTWDADGHRYPGFFCPRLSDTPEEAYCCHTQAAGGFCCTLAEFEALNQVNLSALRPPPIFRGPGPLLALSLYSLLLVALMTADLVHFCRVRGRGRDQCRDLSPSSDRRPSRSSTARPLQASSVEQLRKDGNELFKCGDYEGALTAYTQALGLGATPQDQAILHRNRAACHLKLEDYEKAETEATKAIEKDGGDIKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIAGQIQEKVRYMSSTDAKVEQMFQILLDPQEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGEPDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSMLGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEVGVSGQGRDNALTLLIKVVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVQDPPGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELNGVMESVIALCASEQEEEQLVAVETLIHAAGKAKRASFITANGVSLLKDLYKRSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQMDVGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSKSEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMLRRAATECMCNLAMSKEVQDLFEATGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPSQELQHRGAVVVLNMVEASREIASTLMESEVLEILSVLAKDEETPVTRAATACLGKAVEYGLIKPSQDGR", "length": 1090, "header": "tr|A0AAA9T3T4-1|A0AAA9T3T4_BOVIN Isoform 1 of Protein unc-45 homolog A OS=Bos taurus OX=9913 GN=UNC45A PE=4 SV=1 CANONICAL=A0AAA9T3T4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4/entry#A0AAA9SJR8-1", "sequence": { "sequence": "MTASSVEQLRKDGNELFKCGDYEGALTAYTQALGLGATPQDQAILHRNRAACHLKLEDYEKAETEATKAIEKDGGDIKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIAGQIQEKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGEPDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSMLGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEVGVSGQGRDNALTLLIKVVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVQDPPGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELNGVMESVIALCASEQEEEQLVAVETLIHAAGKAKRASFITANGVSLLKDLYKRSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQMDVGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSKSEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMLRRAATECMCNLAMSKEVQDLFEATGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPSQELQHRGAVVVLNMVEASREIASTLMESEVLEILSVLAKDEETPVTRAATACLGKAVEYGLIKPSQDGR", "length": 898, "header": "tr|A0AAA9SJR8-1|A0AAA9T3T4_BOVIN Computationally mapped isoform of Protein unc-45 homolog A OS=Bos taurus OX=9913 GN=UNC45A PE=4 SV=1 CANONICAL=A0AAA9T3T4-1" }, "locus": { "chromosome": "21", "start_pos": 21729273, "end_pos": 21714985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097585.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097585.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082825.1" } ] } }, { "isoform_ac": "A0AAA9T3T4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4/entry#A0AAA9T3T4-1", "sequence": { "sequence": "MGFQRRSGSLLTGLSVGLLLFFSWMMPAQPASLSALAHHPHLCQTTWDADGHRYPGFFCPRLSDTPEEAYCCHTQAAGGFCCTLAEFEALNQVNLSALRPPPIFRGPGPLLALSLYSLLLVALMTADLVHFCRVRGRGRDQCRDLSPSSDRRPSRSSTARPLQASSVEQLRKDGNELFKCGDYEGALTAYTQALGLGATPQDQAILHRNRAACHLKLEDYEKAETEATKAIEKDGGDIKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIAGQIQEKVRYMSSTDAKVEQMFQILLDPQEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGEPDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSMLGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEVGVSGQGRDNALTLLIKVVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVQDPPGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELNGVMESVIALCASEQEEEQLVAVETLIHAAGKAKRASFITANGVSLLKDLYKRSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQMDVGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSKSEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMLRRAATECMCNLAMSKEVQDLFEATGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPSQELQHRGAVVVLNMVEASREIASTLMESEVLEILSVLAKDEETPVTRAATACLGKAVEYGLIKPSQDGR", "length": 1090, "header": "tr|A0AAA9T3T4-1|A0AAA9T3T4_BOVIN Isoform 1 of Protein unc-45 homolog A OS=Bos taurus OX=9913 GN=UNC45A PE=4 SV=1 CANONICAL=A0AAA9T3T4-1" }, "locus": { "chromosome": "21", "start_pos": 21730940, "end_pos": 21714985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132721.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132721.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091307.1" } ] } }, { "isoform_ac": "F6PRQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3T4/entry#F6PRQ6-1", "sequence": { "sequence": "MTVSGPGNPEPQSVGPGASSVEQLRKDGNELFKCGDYEGALTAYTQALGLGATPQDQAILHRNRAACHLKLEDYEKAETEATKAIEKDGGDIKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIAGQIQEKVRYMSSTDAKVEQMFQILLDPQEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGEPDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSMLGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEVGVSGQGRDNALTLLIKVVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVQDPPGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELNGVMESVIALCASEQEEEQLVAVETLIHAAGKAKRASFITANGVSLLKDLYKRSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQMDVGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSKSEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMLRRAATECMCNLAMSKEVQDLFEATGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPSQELQHRGAVVVLNMVEASREIASTLMESEVLEILSVLAKDEETPVTRAATACLGKAVEYGLIKPSQDGR", "length": 944, "header": "tr|F6PRQ6-1|F6PRQ6_BOVIN Computationally mapped isoform of Protein unc-45 homolog A OS=Bos taurus OX=9913 GN=UNC45A PE=4 SV=1 CANONICAL=A0AAA9T3T4-1" }, "locus": { "chromosome": "21", "start_pos": 21729273, "end_pos": 21714985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024799.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024799.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024799.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024799.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q32PZ3-1", "protein_name": "Protein unc-45 homolog A", "gene_name": "Unc45a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVSGPGTPEPRPSDPGASSAEELRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEIGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVPEAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIRSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVALLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPNPELQHRGTVVVLNMMESSKEIASTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE", "length": 944 }, "evidence": [ { "id": "A0AAA9T3T4", "url": "https://omabrowser.org/oma/group/A0AAA9T3T4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99KD5-1", "protein_name": "Protein unc-45 homolog A", "gene_name": "Unc45a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTVSGPETPEPRPSDPGASSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTEETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVIFDALKEGVKKGFRGKEGAIIVDPARELKVLINSLLELLTEVGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSLQDAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIRNWFEGHGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEREEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPALCSRIPQVTTHWLEILQALLLSPNQELQHRGTVVVLNMMQSSKEIAGTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE", "length": 944 }, "evidence": [ { "id": "A0AAA9T3T4", "url": "https://omabrowser.org/oma/group/A0AAA9T3T4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H3U1-1", "protein_name": "Protein unc-45 homolog A", "gene_name": "UNC45A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLDLLTEVGVSGQGRDNALTLLIKAVPRKSLKDPNNSLTLWVIDQGLKKILEVGGSLQDPPGELAVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIKSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKCSEKDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDAAALKALFQLSRLEERSVLFAVASALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMVCMVKTESPVLTSSCRELLSRVFLALVEEVEDRGTVVAQGGGRALIPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLNCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLQRAAAGGLAMLTSMRPTLCSRIPQVTTHWLEILQALLLSSNQELQHRGAVVVLNMVEASREIASTLMESEMMEILSVLAKGDHSPVTRAAAACLDKAVEYGLIQPNQDGE", "length": 944 }, "evidence": [ { "id": "A0AAA9T3T4", "url": "https://omabrowser.org/oma/group/A0AAA9T3T4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHW4-1", "protein_name": "Uncoordinated 45, isoform B", "gene_name": "unc-45", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"id": "A0AAA9SKV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2K7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2K7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N733", "url": "https://www.uniprot.org/uniprotkb/F1N733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N733-1", "url": "https://www.uniprot.org/uniprotkb/F1N733-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1F9", "url": "https://www.uniprot.org/uniprotkb/G3N1F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1F9-1", "url": "https://www.uniprot.org/uniprotkb/G3N1F9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPDSFCWLSQQEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 526, "header": "tr|A0AAA9T2A3-1|A0AAA9T2A3_BOVIN Isoform 1 of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0A3Q1MTW8-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKQEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 527, "header": "tr|A0A3Q1MTW8-1|A0A3Q1MTW8_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076657.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076657.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058209.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058209.1" } ] } }, { "isoform_ac": "A0AAA9SKV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0AAA9SKV8-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 445, "header": "tr|A0AAA9SKV8-1|A0AAA9T2A3_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115744.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115744.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084514.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084514.1" } ] } }, { "isoform_ac": "A0AAA9SWD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0AAA9SWD7-1", "sequence": { "sequence": "MPGSGRLPGGRHSHPLQYTYLENPHGQRSLAGYSLRGRTEYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTGKQPMADLSHTLKTVLEAAGSHTGVNGFEEGFNHCVSAPSHVIVMFCKLQVFELMYFLKMREEGHTFCLKNNYSESCSLLLPRLL", "length": 528, "header": "tr|A0AAA9SWD7-1|A0AAA9T2A3_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64629837, "end_pos": 64608079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097967.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097967.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088352.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088352.1" } ] } }, { "isoform_ac": "A0AAA9T2A3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0AAA9T2A3-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPDSFCWLSQQEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 526, "header": "tr|A0AAA9T2A3-1|A0AAA9T2A3_BOVIN Isoform 1 of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089789.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089789.1" } ] } }, { "isoform_ac": "A0AAA9T2K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0AAA9T2K7-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 490, "header": "tr|A0AAA9T2K7-1|A0AAA9T2K7_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123420.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123420.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093029.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093029.1" } ] } }, { "isoform_ac": "A0AAA9TFL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#A0AAA9TFL2-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLSPGQKGKEEPKEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 481, "header": "tr|A0AAA9TFL2-1|A0AAA9TFL2_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=1 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117458.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117458.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094965.1" } ] } }, { "isoform_ac": "F1N733-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#F1N733-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEETSLESDIPAPPSSSAPGRPQLKPQQEIKLSVPKSYTLKVHYKYTVVMETQFRLPYSQVRDMVAKKLDLLPEHTKLSYRRQDSNELVPLSEFSMKDAWAQVKNYCLTLWCENTVGDQGFPDEPEESKKSDANNQTTEPELKEGSKVVALFSYEATQPEDLEFLEGDVILVISTVNEEWLEGECKGKVGIFPKAFVEQHPTTDLESTPGRV", "length": 519, "header": "tr|F1N733-1|F1N733_BOVIN Computationally mapped isoform of Neutrophil cytosol factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=3 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64606145, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010525.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010525.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010525.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010525.4" } ] } }, { "isoform_ac": "G3N1F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3/entry#G3N1F9-1", "sequence": { "sequence": "MSLAEAISLWNEGVLAADKKDWKGALDAFTGVQDPHSRICFNVGCIYTILGNLPEAEKAFTKSINRDKHLAVSYFQRGMLYYQMEKYDSAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKREEWKKAEEHLALAVSMKSEPRHSKIDRAMESVWKQKLYEPVVIPVGRLFRPNEKQVAQLVKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFR", "length": 238, "header": "tr|G3N1F9-1|G3N1F9_BOVIN Computationally mapped isoform of Neutrophil cytosolic factor 2 OS=Bos taurus OX=9913 GN=NCF2 PE=3 SV=3 CANONICAL=A0AAA9T2A3-1" }, "locus": { "chromosome": "16", "start_pos": 64638644, "end_pos": 64619070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063771.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063771.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055702.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055702.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1222556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1222556", "resource": "Reactome", "description": "ROS and RNS production in phagocytes" }, { "id": "R-BTA-1236973", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1236973", "resource": "Reactome", "description": "Cross-presentation of particulate exogenous antigens (phagosomes)" }, { "id": "R-BTA-3299685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3299685", "resource": "Reactome", "description": "Detoxification of Reactive Oxygen Species" }, { "id": "R-BTA-4420097", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4420097", "resource": "Reactome", "description": "VEGFA-VEGFR2 Pathway" }, { "id": "R-BTA-5668599", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668599", "resource": "Reactome", "description": "RHO GTPases Activate NADPH Oxidases" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YDM1-1", "protein_name": "Neutrophil cytosolic factor 2", "gene_name": "NCF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLVETIRLWQEGVCAADGKEWGAALKAFTAVQNPPAKICFNIGCTHLVLGQLAEAEEAFTQSISCDKHLAVAYFQRGTVFYKRHNHEMALKDFKEALAQLRGNQLIDYKILGLRYRLFACEILYNIALVYATMENWKKAEEHLTLAMSSKSEPQHNKIDRAMEAILKQKLYEPVAIPTGKLFRPNEKQVAQLEKKDYLGKAMVVASVVDKDSFSGFAPLQPQASGPPPRPKTPEILRALEGQPHRVLYEFIPETAEELQVLPGNIVFVLKKEKDNWATVMFNGKKGIVPCNFLEPMELQHKLHVQDEAPLEPDIPEPPSSTAPRPRRPAPDCVPVTSTQQREASKESEPDIPKPYVLKVHYKYTVAMQVKPDLSYKELLGLVCDKLELQPEHTMLRYKSAASGELVTLSAQNLEEAWSHSKDQCLTVWCDCTEGEGFLPDSKPEEPQQAAAETGPTQVVAQYSYEATQPEDLEFQAGDVILVLSKVNEDWLEGQCNGKIGIFPSAFVRDGNTKDP", "length": 516 }, "evidence": [ { "id": "A0AAA9T2A3", "url": "https://omabrowser.org/oma/group/A0AAA9T2A3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O70145-1", "protein_name": "Neutrophil cytosol factor 2", "gene_name": "Ncf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLAEAIRLWNEGVLAADKKDWKGALEAFSEVQDPHSRICFNIGCVNTILENLQAAEQAFTKSINRDKHSAVAYFQRGMLYYRMEKYDLAIKDLKEALTQLRGNQLIDYKILGLQFKLFACEVLYNIALMHAKKEEWKKAEEQLALATNMKSEPRHSKIDKAMESIWKQKLFEPVVIPVGRLFRPNERQVAQLAKKDYLGKATVVASVVHQDNFSGFAPLQPQSAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGSDNWATVMFNGQKGLVPCNYLEPVELRIHPQSQPQEDTSPESDIPPPPNSSPPGRLQLSPGHKQKEPKELKLSVPMPYMLKVHYKYTVVMETRLGLPYSQLRNMVSKKLALSPEHTKLSYRRRDSHELLLLSEESMKDAWGQVKNYCLTLWCEHTVGDQGLIDEPIQRENSDASKQTTEPQPKEGTQVVAIFSYEAAQPEDLEFVEGDVILVLSHVNEEWLEGECKGKVGIFPKAFVEGCAAKNLEGIPREV", "length": 525 }, "evidence": [ { "id": "A0AAA9T2A3", "url": "https://omabrowser.org/oma/group/A0AAA9T2A3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P19878-1", "protein_name": "Neutrophil cytosol factor 2", "gene_name": "NCF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV", "length": 526 }, "evidence": [ { "id": "A0AAA9T2A3", "url": "https://omabrowser.org/oma/group/A0AAA9T2A3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "NADPH oxidase complex", "id": "GO:0043020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2A3", 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"MKYSLSPDNYSEDGIMNMATFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHYNGKSHRKRVKQLSDGQPSSPAQGSGPPPPASPSTHTSTGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSNSAVGLFPNFNTKRRGLFGTNKFCQMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALEATKNKPKMVSSKDSAKANPSCSITPITGNNSDKSEEKGKLKGSISNQVSSSEGGLFLPKPGTAALPPAAATSPSKSTNGAPGTVSESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPPRPSASLFQAAAIPPALLRPGHGPIRATPASILFAPY", "length": 506, "header": "tr|A0AAA9T3N7-1|A0AAA9T3N7_BOVIN Isoform 1 of Zinc finger protein 385B OS=Bos taurus OX=9913 GN=ZNF385B PE=4 SV=1 CANONICAL=A0AAA9T3N7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7/entry#A0AAA9SVV5-1", "sequence": { "sequence": "MWSGLPSRGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSNSAVGLFPNFNTMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALEATKNKPKMVSSKDSAKANPSCSITPITGNNSDKSEEKGKLKGSISNQVSSSEGGLFLPKPGTAALPPAAATSPSKSTNGAPGTVSESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPPRPSASLFQAAAIPPALLRPGHGPIRATPASILFAPY", "length": 395, "header": "tr|A0AAA9SVV5-1|A0AAA9T3N7_BOVIN Computationally mapped isoform of Zinc finger protein 385B OS=Bos taurus OX=9913 GN=ZNF385B PE=4 SV=1 CANONICAL=A0AAA9T3N7-1" }, "locus": { "chromosome": "2", "start_pos": 17440977, "end_pos": 17104008, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104078.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104078.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088336.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088336.1" } ] } }, { "isoform_ac": "A0AAA9T3N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7/entry#A0AAA9T3N7-1", "sequence": { "sequence": "MKYSLSPDNYSEDGIMNMATFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHYNGKSHRKRVKQLSDGQPSSPAQGSGPPPPASPSTHTSTGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSNSAVGLFPNFNTKRRGLFGTNKFCQMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALEATKNKPKMVSSKDSAKANPSCSITPITGNNSDKSEEKGKLKGSISNQVSSSEGGLFLPKPGTAALPPAAATSPSKSTNGAPGTVSESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPPRPSASLFQAAAIPPALLRPGHGPIRATPASILFAPY", "length": 506, "header": "tr|A0AAA9T3N7-1|A0AAA9T3N7_BOVIN Isoform 1 of Zinc finger protein 385B OS=Bos taurus OX=9913 GN=ZNF385B PE=4 SV=1 CANONICAL=A0AAA9T3N7-1" }, "locus": { "chromosome": "2", "start_pos": 17440977, "end_pos": 17076676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091257.1" } ] } }, { "isoform_ac": "F6Q0S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7/entry#F6Q0S9-1", "sequence": { "sequence": "MKYSLSPDNYSEDGIMNMATFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHYNGKSHRKRVKQLSDGQPSSPAQGSGPPPPASPSTHTSTGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDSNSAVGLFPNFNTMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSKHAKKVKALEATKNKPKMVSSKDSAKANPSCSITPITGNNSDKSEEKGKLKGSISNQVSSSEGGLFLPKPGTAALPPAAATSPSKSTNGAPGTVSESEEEKAKKLLYCSLCKVAVNSLSQLEAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSEIQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSPLAAAAAVSSALSLPPRPSASLFQAAAIPPALLRPGHGPIRATPASILFAPY", "length": 493, "header": "tr|F6Q0S9-1|F6Q0S9_BOVIN Computationally mapped isoform of Zinc finger protein 385B OS=Bos taurus OX=9913 GN=ZNF385B PE=4 SV=1 CANONICAL=A0AAA9T3N7-1" }, "locus": { "chromosome": "2", "start_pos": 17440977, "end_pos": 17076676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030828.4", "url": "https://www.ensembl.org/id/ENSBTAT00000030828.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030798.3", "url": "https://www.ensembl.org/id/ENSBTAP00000030798.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 497, "start_aa": "Thr", "end_pos": 497, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr497", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3N7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N7" }, { "id": "PS00028", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 216, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 497 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T249-1", "uniprot_ac": "A0AAA9T249", "uniprot_id": "A0AAA9T249_BOVIN", "mass": { "chemical_mass": 19951.0, "monoisotopic_mass": 19951.0 }, "refseq": {}, "gene_names": [ { "name": "C10H15orf62", "type": "recommended", "evidence": [ { "id": "A0AAA9T249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ] } ], "protein_names": [ { "name": "Chromosome 10 C15orf62 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9T249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C10H15orf62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249", "locus": { "chromosome": "10", "start_pos": 36322187, "end_pos": 36318264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047281", "url": "https://www.ensembl.org/id/ENSBTAG00000047281" } ] } } ], "crossref": [ { "id": "ENSBTAG00000047281", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047281", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100297536", "url": "https://www.ncbi.nlm.nih.gov/gene/100297536", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297536", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297536", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HKKLGNQ", "url": "https://omabrowser.org/oma/group/HKKLGNQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR15344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15344:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15344:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14957", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14957", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SWN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T249-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX09", "url": "https://www.uniprot.org/uniprotkb/G3MX09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX09-1", "url": "https://www.uniprot.org/uniprotkb/G3MX09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METWRKGSFRSPSFFKRLSLGRPRRLRRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESFSCPNILEAPSAEYTAAYSATLPSALSVADNLHRSSEEDLTDTPPFQRTPAPDLSDPFFSFKVDLGISLLEEVLQMLREQFPSELSF", "length": 176, "header": "tr|A0AAA9T249-1|A0AAA9T249_BOVIN Isoform 1 of Chromosome 10 C15orf62 homolog OS=Bos taurus OX=9913 GN=C10H15orf62 PE=4 SV=1 CANONICAL=A0AAA9T249-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249/entry#A0AAA9SWN0-1", "sequence": { "sequence": "METWRKGSFRSPSFFKRLSLGRPRRLRRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESFSCPNILEAPSAEYTAAYSATLPSALSVADNLHRSSEEDLTDTPPFQRTPAPDLSDPFFSFKVDLGISLLEEVLQMLREQFPKYGRSDQGMDTKLKAVTLKRHSWSPESPPRPRSLAQSL", "length": 209, "header": "tr|A0AAA9SWN0-1|A0AAA9T249_BOVIN Computationally mapped isoform of Chromosome 10 C15orf62 homolog OS=Bos taurus OX=9913 GN=C10H15orf62 PE=4 SV=1 CANONICAL=A0AAA9T249-1" }, "locus": { "chromosome": "10", "start_pos": 36320762, "end_pos": 36319225, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113933.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113933.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087644.1" } ] } }, { "isoform_ac": "A0AAA9T249-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249/entry#A0AAA9T249-1", "sequence": { "sequence": "METWRKGSFRSPSFFKRLSLGRPRRLRRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESFSCPNILEAPSAEYTAAYSATLPSALSVADNLHRSSEEDLTDTPPFQRTPAPDLSDPFFSFKVDLGISLLEEVLQMLREQFPSELSF", "length": 176, "header": "tr|A0AAA9T249-1|A0AAA9T249_BOVIN Isoform 1 of Chromosome 10 C15orf62 homolog OS=Bos taurus OX=9913 GN=C10H15orf62 PE=4 SV=1 CANONICAL=A0AAA9T249-1" }, "locus": { "chromosome": "10", "start_pos": 36319752, "end_pos": 36319225, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123830.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123830.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091805.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091805.1" } ] } }, { "isoform_ac": "G3MX09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249/entry#G3MX09-1", "sequence": { "sequence": "METWRKGSFRSPSFFKRLSLGRPRRLRRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESFSCPNILEAPSAEYTAAYSATLPSALSVADNLHRSSEEDLTDTPPFQRTPAPDLSDPFFSFKVDLGISLLEEVLQMLREQFPKRTKTSTLILQAKWSSLCAMVC", "length": 193, "header": "tr|G3MX09-1|G3MX09_BOVIN Computationally mapped isoform of Chromosome 10 C15orf62 homolog OS=Bos taurus OX=9913 GN=C10H15orf62 PE=4 SV=3 CANONICAL=A0AAA9T249-1" }, "locus": { "chromosome": "10", "start_pos": 36322162, "end_pos": 36319225, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066167.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066167.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054067.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054067.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297536", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297536", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PHX7-1", "protein_name": "Chromosome 15 open reading frame 62", "gene_name": "C15orf62", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDTWRRGSIKSTTFFRRFSLRRHKKLGNQVIILNKNSHTLDSDGQCQKRECLRDLKDKSDYLSCQSEQNLAKAQAPPKPPRLYLDSSSCPNIIDHTDSHSDVSFSDSSHQYNKATQTQFHKDQATDCVTSEPGSQNGTTLSDLSDPFLSFKVDLGLSLLEDVLQTLRKQNPRDYAI", "length": 176 }, "evidence": [ { "id": "A0AAA9T249", "url": "https://omabrowser.org/oma/group/A0AAA9T249/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A287BFH1-1", "protein_name": "Chromosome 1 C15orf62 homolog", "gene_name": "C15orf62", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METWRKGSFRSASFFKRLSLGRPRRLRRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEQPRVTLLAPPKPPRLYRESSSCPNILEPPSAYTAAYSATLPSALSLAEALHQYTEEELLDTPPCQRTPAPDLSDPFFSFQVDLGISLLEEVLQMLREQFPSESSF", "length": 175 }, "evidence": [ { "id": "A0AAA9T249", "url": "https://omabrowser.org/oma/group/A0AAA9T249/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A1S9-1", "protein_name": "Similar to human chromosome 15 open reading frame 62", "gene_name": "C3h15orf62", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLRNSMETWRKGSFRNASFFKRITLGRPRRLQRQGSVLSQASTAGGDHEEYSNREVIRELRGRPDGRRLPLWGDEHPRATLLAPPKPPRLYRESSSCPNILEPPATYTTAYSATLPSAISLTGPLHQCSEEGLLDTPHFPRTPTPDLSDPFFSFKVDLGLSLLEEVLQILKEQFPSEPHF", "length": 181 }, "evidence": [ { "id": "A0AAA9T249", "url": "https://omabrowser.org/oma/group/A0AAA9T249/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8K5M9-1", "protein_name": "Uncharacterized protein C15orf62, mitochondrial", "gene_name": "C15orf62", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METWRKGSFRNASFFKQLSLGRPRRLRRQSSVLSQASTAGGDHEEYSNREVIRELQGRPDGRRLPLWGDEQPRATLLAPPKPPRLYRESSSCPNILEPPPAYTAAYSATLPSALSLSSALHQHSEKGLVDTPCFQRTPTPDLSDPFLSFKVDLGISLLEEVLQMLREQFPSEPSF", "length": 175 }, "evidence": [ { "id": "A0AAA9T249", "url": "https://omabrowser.org/oma/group/A0AAA9T249/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "Rho protein signal transduction", "id": "GO:0007266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" }, { "name": "positive regulation of pseudopodium assembly", "id": "GO:0031274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031274", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T249", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T249" }, { "id": "PF14957", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14957" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cdc42 effector-like", "eco_id": "ECO_0000259", "start_pos": 78, "end_pos": 166, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4I3-1", "uniprot_ac": "A0AAA9T4I3", "uniprot_id": "A0AAA9T4I3_BOVIN", "mass": { "chemical_mass": 23445.0, "monoisotopic_mass": 23445.0 }, "refseq": { "ac": "XP_005224824", "name": "ADP-ribosylation factor-like protein 6-interacting protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224824" }, "gene_names": [ { "name": "ARL6IP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T4I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ] }, { "name": "ARL6IP1", "type": "synonym", "evidence": [ { "id": "XP_005224824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224824" } ] } ], "protein_names": [ { "name": "ADP ribosylation factor like GTPase 6 interacting protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T4I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3/entry#names_and_taxonomy" } ] }, { "name": "ADP-ribosylation factor-like protein 6-interacting protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005224824", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224824" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARL6IP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3", "locus": { "chromosome": "25", "start_pos": 16433450, "end_pos": 16442049, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049516", "url": "https://www.ensembl.org/id/ENSBTAG00000049516" } ] } } ], "crossref": [ { "id": "A0AAA9T4I3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4I3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22559", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22559", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "777773", "url": "https://www.ncbi.nlm.nih.gov/gene/777773", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR052114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR20952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20952:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20952:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224824", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224824", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLTIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIISLAAVAWVGQQVHNLLLTYLIVIFFLLLPGLNQHGIISKYIGMAKREINKLLKQKEKKNE", "length": 203, "header": "tr|A0AAA9T4I3-1|A0AAA9T4I3_BOVIN Isoform 1 of ADP ribosylation factor like GTPase 6 interacting protein 1 OS=Bos taurus OX=9913 GN=ARL6IP1 PE=4 SV=1 CANONICAL=A0AAA9T4I3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3/entry#A0AAA9SWN8-1", "sequence": { "sequence": "MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMVIFFLLLPGLNQHGIISKYIGMAKREINKLLKQKEKKNE", "length": 88, "header": "tr|A0AAA9SWN8-1|A0AAA9T4I3_BOVIN Computationally mapped isoform of ADP ribosylation factor like GTPase 6 interacting protein 1 OS=Bos taurus OX=9913 GN=ARL6IP1 PE=4 SV=1 CANONICAL=A0AAA9T4I3-1" }, "locus": { "chromosome": "25", "start_pos": 16441980, "end_pos": 16434831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129143.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129143.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088478.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088478.1" } ] } }, { "isoform_ac": "A0AAA9T4I3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3/entry#A0AAA9T4I3-1", "sequence": { "sequence": "MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLTIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIISLAAVAWVGQQVHNLLLTYLIVIFFLLLPGLNQHGIISKYIGMAKREINKLLKQKEKKNE", "length": 203, "header": "tr|A0AAA9T4I3-1|A0AAA9T4I3_BOVIN Isoform 1 of ADP ribosylation factor like GTPase 6 interacting protein 1 OS=Bos taurus OX=9913 GN=ARL6IP1 PE=4 SV=1 CANONICAL=A0AAA9T4I3-1" }, "locus": { "chromosome": "25", "start_pos": 16441980, "end_pos": 16434831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126688.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126688.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091583.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" }, { "name": "Sec61 translocon complex", "id": "GO:0005784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005784", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" }, { "name": "positive regulation of L-glutamate import across plasma membrane", "id": "GO:0002038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I3" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network formation", "id": "GO:0071787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4I3", 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"strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017031", "url": "https://www.ensembl.org/id/ENSBTAG00000017031" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017031", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017031", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027962", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027962", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GQDIWED", "url": "https://omabrowser.org/oma/group/GQDIWED/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23034", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23034", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23034:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23034:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T0X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B840", "url": "https://www.uniprot.org/uniprotkb/E1B840", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B840-1", "url": "https://www.uniprot.org/uniprotkb/E1B840-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1507, "header": "tr|A0AAA9T0X5-1|A0AAA9T0X5_BOVIN Isoform 1 of Glutamate rich 3 OS=Bos taurus OX=9913 GN=ERICH3 PE=4 SV=1 CANONICAL=A0AAA9T0X5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0X5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5/entry#A0AAA9T0X5-1", "sequence": { "sequence": 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"length": 1507, "header": "tr|A0AAA9T0X5-1|A0AAA9T0X5_BOVIN Isoform 1 of Glutamate rich 3 OS=Bos taurus OX=9913 GN=ERICH3 PE=4 SV=1 CANONICAL=A0AAA9T0X5-1" }, "locus": { "chromosome": "3", "start_pos": 70178060, "end_pos": 70061630, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135333.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135333.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091348.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091348.1" } ] } }, { "isoform_ac": "E1B840-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5/entry#E1B840-1", "sequence": { "sequence": "MFAKGKKAMMKFRNSMDNSQGMNRYQFPSINRYIMPIPPPLPPTSGKITRENRPETWRRRRFRPTTAPNGLEPVFTKDSRRIHKTPLHSNAAITMIYLGKSVHLAYDHSDFRDEIKVYQQHCGGENLCVYTGKLLEKETFQFISKRHQGFPFSLTFFLNGIQVNRLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKTTSPKPRKEKNAEKKEGQKKGEGKLRKDREYLIPRRREMEGSKASASAIVSAQELHAGLSEVRTAVEEMECKEKPGQDVWEDDQENIFKYEYEEDFEADEEKQDGKANEEGQADDQMNEMSKSPSEDEKDHLDPERESETSLWKAPDADDNVKDEGDGCSESELEDDKQDGKTASSTSSRSHPYSSSSEDESAVGDQETNAENSPDESVRSPSSQELSENDKPGKTHLPTEDSPEIEEQEIIKTDVETKPLLIEENLENVLEQEAEKGTGMIAESLFEKSREHVSKEEKEKRKSKLWEESTAKVKDKKAGPHRVDKGGKYGL", "length": 532, "header": "tr|E1B840-1|E1B840_BOVIN Computationally mapped isoform of Glutamate rich 3 OS=Bos taurus OX=9913 GN=ERICH3 PE=4 SV=3 CANONICAL=A0AAA9T0X5-1" }, "locus": { "chromosome": "3", "start_pos": 70160142, "end_pos": 70108633, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037666.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037666.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037492.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037492.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 149, "start_aa": "Thr", "end_pos": 149, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr149", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5" } ], "pmid": "" }, { "name": "non-motile cilium", "id": "GO:0097730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T0X5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0X5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1108, "end_pos": 1110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1157, "end_pos": 1159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], 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115, "end_pos": 117 }, { "start_pos": 26, "end_pos": 28 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T159-1", "uniprot_ac": "A0AAA9T159", "uniprot_id": "A0AAA9T159_BOVIN", "mass": { "chemical_mass": 38689.0, "monoisotopic_mass": 38689.0 }, "refseq": {}, "gene_names": [ { "name": "C13H20orf96", "type": "recommended", "evidence": [ { "id": "A0AAA9T159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159" } ] } ], "protein_names": [ { "name": "Chromosome 13 C20orf96 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9T159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T159", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C13H20orf96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159", "locus": { "chromosome": "13", "start_pos": 60744561, "end_pos": 60720562, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002115", "url": "https://www.ensembl.org/id/ENSBTAG00000002115" } ] } } ], "crossref": [ { "id": "A0AAA9T159", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T159", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR029236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CNHEDFL", "url": "https://omabrowser.org/oma/group/CNHEDFL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR28574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28574:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28574:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T159", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T159-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVFSRPNTLQTQPLWDRLHSPPVPGSGWQSKPTLWMTSQPRNPLELRRGKLDSGKTQATIRLMRTMLRNRRTSYQELCDHEEFLTNHCGELIKTIQDTEDSAALKVRMLLQQQDVYMTITDILEYSNKKKLHQMKCELQEWEEKEEAKIRNLEQQVEQLDAQIEKVREQVSFVSTYKDHEYPIKLVQVGNLVRQLQQVKDSQLDELDELSEMCRMVLASMSNQIQNKKKNLLRSLVVKIQRANQETLLQKTWNTRVILKYMDKFQEFIDRFEEEIPRLRAEMEQLEFQIWEPREIVFADVLLRRSKCTPDMDVVLNIPVEEPLPF", "length": 326, "header": "tr|A0AAA9T159-1|A0AAA9T159_BOVIN Isoform 1 of Chromosome 13 C20orf96 homolog OS=Bos taurus OX=9913 GN=C13H20orf96 PE=4 SV=1 CANONICAL=A0AAA9T159-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T159-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T159/entry#A0AAA9T159-1", "sequence": { "sequence": "MGVFSRPNTLQTQPLWDRLHSPPVPGSGWQSKPTLWMTSQPRNPLELRRGKLDSGKTQATIRLMRTMLRNRRTSYQELCDHEEFLTNHCGELIKTIQDTEDSAALKVRMLLQQQDVYMTITDILEYSNKKKLHQMKCELQEWEEKEEAKIRNLEQQVEQLDAQIEKVREQVSFVSTYKDHEYPIKLVQVGNLVRQLQQVKDSQLDELDELSEMCRMVLASMSNQIQNKKKNLLRSLVVKIQRANQETLLQKTWNTRVILKYMDKFQEFIDRFEEEIPRLRAEMEQLEFQIWEPREIVFADVLLRRSKCTPDMDVVLNIPVEEPLPF", "length": 326, "header": "tr|A0AAA9T159-1|A0AAA9T159_BOVIN Isoform 1 of Chromosome 13 C20orf96 homolog OS=Bos taurus OX=9913 GN=C13H20orf96 PE=4 SV=1 CANONICAL=A0AAA9T159-1" }, "locus": { "chromosome": "13", "start_pos": 60743557, "end_pos": 60724269, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123956.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123956.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090108.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090108.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QVU6-1", "protein_name": "Chromosome 17 C20orf96 homolog", "gene_name": "C17H20orf96", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARVFPKPDHDGICSTVHQFQILDYVPWQRSKPKAKTSSLPPISQTTDTKKSKMKILTTVQPGVQARPTLWMTSQPRNPLELRRGKLDSGKTHNKIRLLRTMLRHRQASHQELCNHEDFLTQLNRELIKAIQDTEDSSALKVRVMLQQHDVFMTIISILEYSNKKRLQQMEHELQEWEEKEESKMHSLEQQVEQLNAKIEKVHEKVSFVSTYKDHEYPIKSVQVASLVRQLQQTKDSQQDELDDLGEMCRMVLASISSQIQKKKKALLGSLVLKIQHAHQETLLQKTLDSQAMLTYMDKVQKFMDQFEEEIPLLRAQMEQLQFQIWEPREIVFADVLLRRSKCTPDTDVILNIPVEELLPF", "length": 361 }, "evidence": [ { "id": "A0AAA9T159", "url": "https://omabrowser.org/oma/group/A0AAA9T159/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YP54-1", "protein_name": "Uncharacterized protein", "gene_name": "C20orf96", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDAKGPGPSAAAEAKRRVGSTWQKAAAERKLAAHELVLPPITDGAKKKGQKNKSAVFVSSKTTPLVLKASPQEKYRTYTERKSALKEAELAEMLEEIRVTTHLTKLKTKAIEELKQCSDHLAKTNCWLMKDIQHTDDSTAKQARDLLHQYEVYQMIEAMTQTVSQNQLDMARAELQEMEKTMEKNVGKLQQQLDEVTSKVQVLQDELSTLRAYTEVQYLNQAMQIVLLLSNIQNLKKQQQDEIEQTEKMGQAILEELEKKAQLEQEEILQKVVEEVLLHQDGLKQMVINNHVLRREIIRQKEIIKDLEEEISELKRSVQTLRQSARDPREMIFADVFLHRPKCTPDTEVVLRIPTEKTPLPRCPQRSDEEPTNAALPSPAALLPPGPARLL", "length": 391 }, "evidence": [ { "id": "A0AAA9T159", "url": "https://omabrowser.org/oma/group/A0AAA9T159/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M1F2-1", "protein_name": "Similar to human chromosome 20 open reading frame 96", "gene_name": "C3h20orf96", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQKRINSRTQFAGHKLQVHMSSGAEKNLKPSTLPPLRQAKGHSKRKTKSVTKIQPVAQSQVSVDMTTATKTPRALRRRDQPHHGKVQAKVRLMKSMLRNQRTSLQELYSHEGYLSKLNQELIKTILETEDSTALSVREMLQQQNILGNIIDILEYSNKKRVQELRSEFQEWKEKEESKTNTLQWEVEQLNSEIRKANEEVNLLSTYMDHEYPIRLVQIANHVRLVQQAKDSQQDELDNLREMREKVLAFFSNIIQEKKRRILKSLVVKTQEPHENRLLLKTRDSRRLQRCVLWFEELIKQLKEEIPMLISEVEQMYAEIWNPREAVFKDVLLQRPKCTPDMAVELNIPTQELFPF", "length": 356 }, "evidence": [ { "id": "A0AAA9T159", "url": "https://omabrowser.org/oma/group/A0AAA9T159/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NUD7-1", "protein_name": "Uncharacterized protein C20orf96", "gene_name": "C20orf96", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAHVLQKPKHSGTHSIVQEFQVPDYVPWQQSKQETKPSTLPPVQQANSLHTSKMKTLTRVQPVFHFKPTTVVTSCQPKNPRELHRRRKLDPGKMHAKIWLMKTSLRSGRAALRELRSRENFLSKLNRELIETIQEMENSTTLHVRALLQQQDTLATIIDILEYSNKKRLQQLKSELQEWEEKKKCKMSYLEQQAEQLNAKIEKTQEEVNFLSTYMDHEYSIKSVQISTLMRQLQQVKDSQQDELDDLGEMRRKVLESLSDKIQKKKKKILSSVVAETQRPYEEALLQKMWESQDFLKCMQRFREIIDQFEENMPVLRAEVEELQAQTREPREVIFEDVLLRRPKCTPDMDVILNIPVEEPLPF", "length": 363 }, "evidence": [ { "id": "A0AAA9T159", "url": "https://omabrowser.org/oma/group/A0AAA9T159/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T176-1", "uniprot_ac": "A0AAA9T176", "uniprot_id": "A0AAA9T176_BOVIN", "mass": { "chemical_mass": 16960.0, "monoisotopic_mass": 16960.0 }, "refseq": {}, "gene_names": [ { "name": "SPA17", "type": "recommended", "evidence": [ { "id": "A0AAA9T176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176" } ] } ], "protein_names": [ { "name": "Sperm surface protein Sp17", "type": "recommended", "evidence": [ { "id": "A0AAA9T176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176/entry#names_and_taxonomy" } ] }, { "name": "Sperm autoantigenic protein 17", "type": "synonym", "evidence": [ { "id": "A0AAA9T176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T176", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176#function" }, { "database": "UniProtKB", "id": "ARBA00025518", "url": "https://www.uniprot.org/uniprotkb/ARBA00025518#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T176", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPA17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T176", "locus": { "chromosome": "29", "start_pos": 28168618, "end_pos": 28154322, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033464", "url": "https://www.ensembl.org/id/ENSBTAG00000033464" } ] } } ], "crossref": 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"publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T194", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T194" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T194", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T194" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T194" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 89, "start_aa": "Gln", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1D0-1", "uniprot_ac": "A0AAA9T1D0", "uniprot_id": "A0AAA9T1D0_BOVIN", "mass": { "chemical_mass": 47964.0, "monoisotopic_mass": 47964.0 }, "refseq": { "ac": "XP_005209198", "name": "RING finger protein 44 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209198" }, "gene_names": [ { "name": "RNF44", "type": "recommended", "evidence": [ { "id": "A0AAA9T1D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0" } ] }, { "name": "RNF44", "type": "synonym", "evidence": [ { "id": "XP_005209198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209198" } ] } ], "protein_names": [ { "name": "RING finger protein 44 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005209198", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209198" } ] }, { "name": "Ring finger protein 44", "type": "synonym", "evidence": [ { "id": "A0AAA9T1D0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0", "locus": { "chromosome": "7", "start_pos": 37999775, "end_pos": 38023195, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017748", "url": "https://www.ensembl.org/id/ENSBTAG00000017748" } ] } } ], "crossref": [ { "id": "A0AAA9T1D0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1D0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017748", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017748", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531968", "url": "https://www.ncbi.nlm.nih.gov/gene/531968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531968", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531968", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MSSEHFV", "url": "https://omabrowser.org/oma/group/MSSEHFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N0G7", "url": "https://www.orthodb.org/?gene=F1N0G7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46171:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46171:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209198", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209198", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0G7", "url": "https://www.uniprot.org/uniprotkb/F1N0G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0G7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0G7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPWALAVTRWAPSAPGGQRRFPAGPSSSPGQLWGSPSHEGPLASLPAQDERFPSQQLPPRPAHLPVEERRASAPAGGSPRMLHPVSQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPAGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPQLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPHPQPAHMAPLGQFMSLQTQHPRMPLQRLDNDVDLRGDQHPLGSFTYSTSAPGPTLSASVPMHYLPHDTLHHELSFGVPYSHVMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFHPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE", "length": 433, "header": "tr|A0AAA9T1D0-1|A0AAA9T1D0_BOVIN Isoform 1 of Ring finger protein 44 OS=Bos taurus OX=9913 GN=RNF44 PE=4 SV=1 CANONICAL=A0AAA9T1D0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0/entry#A0AAA9T1D0-1", "sequence": { "sequence": "MQPWALAVTRWAPSAPGGQRRFPAGPSSSPGQLWGSPSHEGPLASLPAQDERFPSQQLPPRPAHLPVEERRASAPAGGSPRMLHPVSQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPAGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPQLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPHPQPAHMAPLGQFMSLQTQHPRMPLQRLDNDVDLRGDQHPLGSFTYSTSAPGPTLSASVPMHYLPHDTLHHELSFGVPYSHVMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFHPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE", "length": 433, "header": "tr|A0AAA9T1D0-1|A0AAA9T1D0_BOVIN Isoform 1 of Ring finger protein 44 OS=Bos taurus OX=9913 GN=RNF44 PE=4 SV=1 CANONICAL=A0AAA9T1D0-1" }, "locus": { "chromosome": "7", "start_pos": 38005292, "end_pos": 38002081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090716.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090716.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090390.1" } ] } }, { "isoform_ac": "F1N0G7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0/entry#F1N0G7-1", "sequence": { "sequence": "MQPWALAVTRWAPSAPGGQRRFPAGPSSSPGQLWGSPSHEGPLASLPAQDERFPSQQLPPRPAHLPVEERRASAPAGGSPRMLHPVSQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPAGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPHPQPAHMAPLGQFMSLQTQHPRMPLQRLDNDVDLRGDQHPLGSFTYSTSAPGPTLSASVPMHYLPHDTLHHELSFGVPYSHVMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFHPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE", "length": 432, "header": "tr|F1N0G7-1|A0AAA9T1D0_BOVIN Computationally mapped isoform of Ring finger protein 44 OS=Bos taurus OX=9913 GN=RNF44 PE=4 SV=2 CANONICAL=A0AAA9T1D0-1" }, "locus": { "chromosome": "7", "start_pos": 38005292, "end_pos": 38002081, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023598.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023598.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023598.5", "url": "https://www.ensembl.org/id/ENSBTAP00000023598.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 245, "start_aa": "Thr", "end_pos": 245, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr245", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531968", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531968", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B8W4-1", "protein_name": "Ring finger protein 44", "gene_name": "RNF44", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQPWALAVTRWPPSAPVGQRRFSAGTSSHPGQLRGSPSREGPLASPPAQDERLPSQQPPPRPAHLPVEERRALAPAGGSPRMLHPTSQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPTGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPHPQPTHMAPLGQFVSLQTQHPRMPLQRLDNDVDLRGDQHPLGSFTYSTSAPGPTLSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFHPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE", "length": 432 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08CG8-1", "protein_name": "RING finger protein 44", "gene_name": "rnf44", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRPWEVAVSRRPTTAPLNQRRLVGEPCITPLHLRRSPPVRHQWGQRDRPALHTSLHQDENFHHAVFSQHQQVPLDESRQYSHSGAAPRMLHTANQPPQQSSIMVDLHEQMHQGSVPISYTVTTVTTHGFPIHTGQPIPACNAQQLPACSVMFSGQLSLLCCLPPPLIQACTMQHLPVSYQAFPPLISSEHFILHPSPAVAPHQPPPHPPHPPPPHLPPINQFVPIQPQHPRMPLQRVENEVDLRGDQHPLGTFSYPPAHHPPALTPSVPLQYLPQETLHQELPYPVPYPHMLPRRITGQRYRLQQPLPPPPPPPPYYPGFLPYFLSMLPVPPTAVGPAISLDLDVDDVEMENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNLENHQSEQTLCVVCFSDFESRQLLRVLPCNHEFHAKCVDKWLKTNRTCPICRADASEVHRDVE", "length": 448 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3UHJ8-1", "protein_name": "RING finger protein 44", "gene_name": "Rnf44", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPWTLAVTKWPPSAPVGHWRVSTRLSSSPGQLWGRPSNLSVEEHRASAPAGRSPRMLHPATQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPTSQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPQLIQACTMQQLPGPYHTYPHLISSDHYILHPPPPAPPPQPTHMAPLGQFVSLQTQHPRMPLQRLDNEMDLRGDQHPLGSFTYSTSATGPALSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPSYYPSFLPYFLSMLPMSPTTVGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFEVRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVPREAE", "length": 407 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4V7B8-1", "protein_name": "RING finger protein 44", "gene_name": "Rnf44", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLHPATQQSPFMVDLHDQVHQGPVPLSYTVTTVTTQGFPLPASQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYHTYPHLISSDHYILHPPPPAPPPQPTHMAPLGQFVSLQTQHPRMPLQRLDNEMDLRGDQHPLGSFTYSTSATGPTLSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPSYYPSFLPYFLSMLPMSPTTVGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFEVRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVPREAE", "length": 350 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7L0R7-1", "protein_name": "RING finger protein 44", "gene_name": "RNF44", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPWALAVTRWPPSAPVGQRRFSAGPGSTPGQLWGSPGLEGPLASPPARDERLPSQQPPSRPPHLPVEERRASAPAGGSPRMLHPATQQSPFMVDLHEQVHQGPVPLSYTVTTVTTQGFPLPTGQHIPGCSAQQLPACSVMFSGQHYPLCCLPPPLIQACTMQQLPVPYQAYPHLISSDHYILHPPPPAPPPQPTHMAPLGQFVSLQTQHPRMPLQRLDNDVDLRGDQPSLGSFTYSTSAPGPALSPSVPLHYLPHDPLHQELSFGVPYSHMMPRRLSTQRYRLQQPLPPPPPPPPPPPYYPSFLPYFLSMLPMSPTAMGPTISLDLDVDDVEMENYEALLNLAERLGDAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVDKWLKANRTCPICRADASEVPREAE", "length": 432 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GIU9-1", "protein_name": "Ring finger protein 44", "gene_name": "RNF44", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPWELAVNRRPPSAPFNQRRFSGGPCSSPDHLRRSPPARRQWGRRDRPLATLLGQDDTQLHPAFPQQPHIPVDEPRAYALPSTPPRMLHPAAHPPHQNPFMVDLHDQVHQGPVPLSYTVTTVTTQGFPIHTSQHIPGCSTQQLPACSVMFSGQHYPLCCLPPPLIQACAMQQLPVSYQTFPPIISSDHYILHPPPPPVPPHQPPHMAPLGQFVPLQAQHPRMPLQRIDNDVDLRGEQHPIAGFTYPPSHHAPTLSPSVPLHYLPHDPLHQELPFGVPYPHMMPRRLNTQRYRLQQALPPPPPPPPPPPYYPSFLPYFLSMLPVSPTAVGPTISLDLDVDDVEMENYEALLNLAERLGEAKPRGLTKADIEHLPSYRFNPESHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVQREAD", "length": 442 }, "evidence": [ { "id": "A0AAA9T1D0", "url": "https://omabrowser.org/oma/group/A0AAA9T1D0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1D0" } ], "pmid": "" }, { "name": "ubiquitin protein 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"database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 381, "end_pos": 422, "start_aa": "Cys", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 245 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 415, "end_pos": 417 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1H1-1", "uniprot_ac": "A0AAA9T1H1", "uniprot_id": "A0AAA9T1H1_BOVIN", "mass": { "chemical_mass": 31210.0, "monoisotopic_mass": 31210.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T1H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1", "locus": {} } ], "crossref": [ { "id": "A0AAA9T1H1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1H1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANERNVTVFILVGLTQNPQMQKIVFVVFLVLYMVTLSGNLLIVVTITTSQALNSPMYFFLTHLSLIDTIYSSSSAPKLIVDSLQEIKTISFNGCMAQVYAEHIFGATEIILLTEMAYDHYVAICKPLHYTAIMSHRLCVLLLGVAWTGGFLHATIQVLFTVWLPFCGPNVIDHFMCDLYPLLKLVCVDTHILGLFVAANSGFICLLNFLLLLVSYVVILHSLRAYSLEGRHRALSTCVSHITVVVLSFVPCIFVYLAQSPLCPLIKLLLSFTLWWPLC", "length": 279, "header": "tr|A0AAA9T1H1-1|A0AAA9T1H1_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T1H1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H1/entry#A0AAA9T1H1-1", "sequence": { "sequence": "MANERNVTVFILVGLTQNPQMQKIVFVVFLVLYMVTLSGNLLIVVTITTSQALNSPMYFFLTHLSLIDTIYSSSSAPKLIVDSLQEIKTISFNGCMAQVYAEHIFGATEIILLTEMAYDHYVAICKPLHYTAIMSHRLCVLLLGVAWTGGFLHATIQVLFTVWLPFCGPNVIDHFMCDLYPLLKLVCVDTHILGLFVAANSGFICLLNFLLLLVSYVVILHSLRAYSLEGRHRALSTCVSHITVVVLSFVPCIFVYLAQSPLCPLIKLLLSFTLWWPLC", "length": 279, "header": "tr|A0AAA9T1H1-1|A0AAA9T1H1_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T1H1-1" }, "locus": { "chromosome": "15", "start_pos": 78135888, "end_pos": 78135052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110800.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110800.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090250.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090250.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1H1", "url": 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"MGLDKQCLSIPLLVLLFGFFPENSYPVFQLPAVLLGTMTTLDDKLLGEKLQYYYSSSEEEDSDHEDKDRGRGALAGSSMPADADLAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSLSCRSHLDEEEEQRKQKDLQEKISGKMTLKDLAVMNEDQDDEEFLQQYRKQRMEEMRQQLYQGPQFKQVFEIPSGEGFLDMIDKEQRSTLIMVHIYEDGIPGTEAMNGCMLCLAAEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLLRTSVRNSATCHSEDSDLEID", "length": 338, "header": "tr|A0AAA9T1I5-1|A0AAA9T1I5_BOVIN Isoform 1 of Phosducin-like protein OS=Bos taurus OX=9913 GN=PDCL PE=3 SV=1 CANONICAL=A0AAA9T1I5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1I5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5/entry#A0AAA9T1I5-1", "sequence": { "sequence": "MGLDKQCLSIPLLVLLFGFFPENSYPVFQLPAVLLGTMTTLDDKLLGEKLQYYYSSSEEEDSDHEDKDRGRGALAGSSMPADADLAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSLSCRSHLDEEEEQRKQKDLQEKISGKMTLKDLAVMNEDQDDEEFLQQYRKQRMEEMRQQLYQGPQFKQVFEIPSGEGFLDMIDKEQRSTLIMVHIYEDGIPGTEAMNGCMLCLAAEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLLRTSVRNSATCHSEDSDLEID", "length": 338, "header": "tr|A0AAA9T1I5-1|A0AAA9T1I5_BOVIN Isoform 1 of Phosducin-like protein OS=Bos taurus OX=9913 GN=PDCL PE=3 SV=1 CANONICAL=A0AAA9T1I5-1" }, "locus": { "chromosome": "11", "start_pos": 93993656, "end_pos": 93988287, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135214.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135214.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091576.1" } ] } }, { "isoform_ac": "A0AAA9TPS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5/entry#A0AAA9TPS9-1", "sequence": { "sequence": "MFKGRHAGVTAPSGEILRQTCTMTTLDDKLLGEKLQYYYSSSEEEDSDHEDKDRGRGALAGSSMPADADLAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSLSCRSHLDEEEEQRKQKDLQEKISGKMTLKDLAVMNEDQDDEEFLQQYRKQRMEEMRQQLYQGPQFKQVFEIPSGEGFLDMIDKEQRSTLIMVHIYEDGIPGTEAMNGCMLCLAAEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLLRTSVRNSATCHSEDSDLEID", "length": 323, "header": "tr|A0AAA9TPS9-1|A0AAA9TPS9_BOVIN Computationally mapped isoform of Phosducin-like protein OS=Bos taurus OX=9913 GN=PDCL PE=3 SV=1 CANONICAL=A0AAA9T1I5-1" }, "locus": { "chromosome": "11", "start_pos": 93994092, "end_pos": 93988287, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099289.1" } ] } }, { "isoform_ac": "A0AAF6ZER0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5/entry#A0AAF6ZER0-1", "sequence": { "sequence": "MTTLDDKLLGEKLQYYYSSSEEEDSDHEDKDRGRGALAGSSMPADADLAGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSLSCRSHLDEEEEQRKQKDLQEKISGKMTLKDLAVMNEDQDDEEFLQQYRKQRMEEMRQQLYQGPQFKQVFEIPSGEGFLDMIDKEQRSTLIMVHIYEDGIPGTEAMNGCMLCLAAEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLLRTSVRNSATCHSEDSDLEID", "length": 293, "header": "tr|A0AAF6ZER0-1|A0AAF6ZER0_BOVIN Computationally mapped isoform of Phosducin like OS=Bos taurus OX=9913 GN=PDCL PE=3 SV=1 CANONICAL=A0AAA9T1I5-1" }, "locus": { "chromosome": "11", "start_pos": 93993118, "end_pos": 93988287, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043370.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043370.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040945.2", "url": "https://www.ensembl.org/id/ENSBTAP00000040945.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" }, { "name": "regulation of G protein-coupled receptor signaling pathway", "id": "GO:0008277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1I5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1I5" }, { "id": "PF02114", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02114" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosducin", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 336, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1K1-1", "uniprot_ac": "A0AAA9T1K1", "uniprot_id": "A0AAA9T1K1_BOVIN", "mass": { "chemical_mass": 36842.0, "monoisotopic_mass": 36842.0 }, "refseq": {}, "gene_names": [ { "name": "PIH1D2", "type": "recommended", "evidence": [ { "id": "A0AAA9T1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ] } ], "protein_names": [ { "name": "PIH1 domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9T1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIH1D2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1", "locus": { "chromosome": "15", "start_pos": 22370256, "end_pos": 22382689, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005156", "url": "https://www.ensembl.org/id/ENSBTAG00000005156" } ] } } ], "crossref": [ { "id": "A0AAA9T1K1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1K1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005156", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005156", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06464", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06464", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR012981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MNJ0", "url": "https://www.orthodb.org/?gene=F1MNJ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22997:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22997:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18201", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18201", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNJ0", "url": "https://www.uniprot.org/uniprotkb/F1MNJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MNJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSSKGLLTQVTQFWNLLDDLAESNPESYQKFIQQQLKEGKELCAAPEPQLCLQTRILKPKEKLLFINLCQWKRIPAPESATHPVPLSIGRPEDISETSDVYTVIDVAYHPDVLQAAEKDQVKKDQLIRMAMRCIEEQFQFTLSNCYYITKFRIKGSIQRMKQNLMGIQTNPADLREKMRNELTLEKIRSSTVSNSDQFPQLLLPEDQVSSKTACLIEEISSTEIKVEMKRPAYELKIVADQNEKPLKIELKVELPGVNSVSLCDLSVSEDDILIEVSEKYRLYLNLPESVDTEMTTAKFIKEKATLIVTMPLVLAHFKNE", "length": 322, "header": "tr|A0AAA9T1K1-1|A0AAA9T1K1_BOVIN Isoform 1 of PIH1 domain-containing protein 2 OS=Bos taurus OX=9913 GN=PIH1D2 PE=3 SV=1 CANONICAL=A0AAA9T1K1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1/entry#A0AAA9T1K1-1", "sequence": { "sequence": "MESSSKGLLTQVTQFWNLLDDLAESNPESYQKFIQQQLKEGKELCAAPEPQLCLQTRILKPKEKLLFINLCQWKRIPAPESATHPVPLSIGRPEDISETSDVYTVIDVAYHPDVLQAAEKDQVKKDQLIRMAMRCIEEQFQFTLSNCYYITKFRIKGSIQRMKQNLMGIQTNPADLREKMRNELTLEKIRSSTVSNSDQFPQLLLPEDQVSSKTACLIEEISSTEIKVEMKRPAYELKIVADQNEKPLKIELKVELPGVNSVSLCDLSVSEDDILIEVSEKYRLYLNLPESVDTEMTTAKFIKEKATLIVTMPLVLAHFKNE", "length": 322, "header": "tr|A0AAA9T1K1-1|A0AAA9T1K1_BOVIN Isoform 1 of PIH1 domain-containing protein 2 OS=Bos taurus OX=9913 GN=PIH1D2 PE=3 SV=1 CANONICAL=A0AAA9T1K1-1" }, "locus": { "chromosome": "15", "start_pos": 22381605, "end_pos": 22370608, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112800.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112800.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089540.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089540.1" } ] } }, { "isoform_ac": "F1MNJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1/entry#F1MNJ0-1", "sequence": { "sequence": "MESSSKGLLTQVTQFWNLLDDLAESNPESYQKFIQQQLKEGKELCAAPEPQLCLQTRILKPKEKLLFINLCQWKRIPAPESATHPVPLSIGRPEDISETSDVYTVIDVAYHPDVLQAAEKDQVKKDQLIRMAMRCIEEQFQFTLSNCYYITKFRIKGSIQRMKQNLMGIQTNPADLREKMRNELTLEKIRSSTVSNSDQFPQLLLPEDQVSSKTACLIEEISSTEIKVEMKRPAYELKIVADQNEKPLKIELKVELPGVNSVSLCDLSVSEGTTEPTLPNNELSLKFH", "length": 288, "header": "tr|F1MNJ0-1|A0AAA9T1K1_BOVIN Computationally mapped isoform of PIH1 domain-containing protein 2 OS=Bos taurus OX=9913 GN=PIH1D2 PE=3 SV=3 CANONICAL=A0AAA9T1K1-1" }, "locus": { "chromosome": "15", "start_pos": 22381605, "end_pos": 22374693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006791.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006791.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006791.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006791.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "R2TP complex", "id": "GO:0097255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097255", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1K1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1K1", "url": 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{ "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1L5-1", "uniprot_ac": "A0AAA9T1L5", "uniprot_id": "A0AAA9T1L5_BOVIN", "mass": { "chemical_mass": 104340.0, "monoisotopic_mass": 104340.0 }, "refseq": { "ac": "XP_010811859", "name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811859" }, "gene_names": [ { "name": "EDEM3", "type": "recommended", "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ] }, { "name": "EDEM3", "type": "synonym", "evidence": [ { "id": "XP_010811859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811859" } ] } ], "protein_names": [ { "name": "alpha-1,2-Mannosidase", "type": "recommended", "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.-", "type": "synonym", "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#names_and_taxonomy" } ] }, { "name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010811859", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811859" } ] } ], "function": [ { "annotation": "Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD. 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"start_pos": 65719553, "end_pos": 65792337, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019264", "url": "https://www.ensembl.org/id/ENSBTAG00000019264" } ] } } ], "crossref": [ { "id": "A0AAA9T1L5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1L5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019264", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019264", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02126", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02126", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519058", "url": "https://www.ncbi.nlm.nih.gov/gene/519058", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RRWDRRE", "url": "https://omabrowser.org/oma/group/RRWDRRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3M5", "url": "https://www.orthodb.org/?gene=A0A3Q1M3M5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B789", "url": "https://www.orthodb.org/?gene=E1B789", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45679:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45679:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010811859", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811859", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "56008", "url": "https://www.rhea-db.org/rhea/56008", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56028", "url": "https://www.rhea-db.org/rhea/56028", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3M5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3M5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B789", "url": "https://www.uniprot.org/uniprotkb/E1B789", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B789-1", "url": "https://www.uniprot.org/uniprotkb/E1B789-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEAGGGRGSGSSVPQRAPWSLVAATAALCLVSATSVWTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQRVSKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVREESLRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGPDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDITIPMLFLFSKEGGIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQSAEQIASRSQEIDLVDQESPEESSVNSHPEALSPVDTDSAASVSSSEQDSNPMENLETTSLDGECTDLDNQLQEQPETEEDSNPNVSWGKKAQPIDSILADWNEDIEAFEMMDKDEL", "length": 932, "header": "tr|A0AAA9T1L5-1|A0AAA9T1L5_BOVIN Isoform 1 of alpha-1,2-Mannosidase OS=Bos taurus OX=9913 GN=EDEM3 PE=3 SV=1 CANONICAL=A0AAA9T1L5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#A0A3Q1M3M5-1", "sequence": { "sequence": "MEPGGGDGRAVPGVGHVRVDGGGRAHESRGEAEAWEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQRVSKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESLRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGPDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDITIPMLFLFSKEGGIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQSAEQIASRSQEIDLVDQESPEESSVNSHPEALSPVDTDSAASVSSSEQDSNPMENLETTSLDGECTDLDNQLQEQPETEEDSNPNVSWGKKAQPIDSILADWNEDIEAFEMMDKDEL", "length": 897, "header": "tr|A0A3Q1M3M5-1|A0A3Q1M3M5_BOVIN Computationally mapped isoform of alpha-1,2-Mannosidase OS=Bos taurus OX=9913 GN=EDEM3 PE=3 SV=2 CANONICAL=A0AAA9T1L5-1" }, "locus": { "chromosome": "16", "start_pos": 65792082, "end_pos": 65723213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073089.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073089.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064383.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064383.2" } ] } }, { "isoform_ac": "A0AAA9T1L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#A0AAA9T1L5-1", "sequence": { "sequence": "MSEAGGGRGSGSSVPQRAPWSLVAATAALCLVSATSVWTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQRVSKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVREESLRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGPDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDITIPMLFLFSKEGGIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQSAEQIASRSQEIDLVDQESPEESSVNSHPEALSPVDTDSAASVSSSEQDSNPMENLETTSLDGECTDLDNQLQEQPETEEDSNPNVSWGKKAQPIDSILADWNEDIEAFEMMDKDEL", "length": 932, "header": "tr|A0AAA9T1L5-1|A0AAA9T1L5_BOVIN Isoform 1 of alpha-1,2-Mannosidase OS=Bos taurus OX=9913 GN=EDEM3 PE=3 SV=1 CANONICAL=A0AAA9T1L5-1" }, "locus": { "chromosome": "16", "start_pos": 65792138, "end_pos": 65723213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091608.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091608.1" } ] } }, { "isoform_ac": "A0AAA9TRR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#A0AAA9TRR4-1", "sequence": { "sequence": "MSEAGGGRGSGSSVPQRAPWSLVAATAALCLVSATSVWTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQRVSKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESLRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQTRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDITIPMLFLFSKEGGIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQSAEQIASRSQEIDLVDQESPEESSVNSHPEALSPVDTDSAASVSSSEQDSNPMENLETTSLDGECTDLDNQLQEQPETEEDSNPNVSWGKKAQPIDSILADWNEDIEAFEMMDKDEL", "length": 867, "header": "tr|A0AAA9TRR4-1|A0AAA9TRR4_BOVIN Computationally mapped isoform of alpha-1,2-Mannosidase OS=Bos taurus OX=9913 GN=EDEM3 PE=3 SV=1 CANONICAL=A0AAA9T1L5-1" }, "locus": { "chromosome": "16", "start_pos": 65792138, "end_pos": 65723213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092974.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092974.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100004.1" } ] } }, { "isoform_ac": "E1B789-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5/entry#E1B789-1", "sequence": { "sequence": "MSEAGGGRGSGSSVPQRAPWSLVAATAALCLVSATSVWTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQRVSKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESLRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGPDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDITIPMLFLFSKEGGIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPNYIINSNPEMENEEQPSSENDSQSAEQIASRSQEIDLVDQESPEESSVNSHPEALSPVDTDSAASVSSSEQDSNPMENLETTSLDGECTDLDNQLQEQPETEEDSNPNVSWGKKAQPIDSILADWNEDIEAFEMMDKDEL", "length": 947, "header": "tr|E1B789-1|E1B789_BOVIN Computationally mapped isoform of alpha-1,2-Mannosidase OS=Bos taurus OX=9913 GN=EDEM3 PE=3 SV=3 CANONICAL=A0AAA9T1L5-1" }, "locus": { "chromosome": "16", "start_pos": 65792138, "end_pos": 65723213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025655.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025655.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025655.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025655.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PEI6-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "EDEM3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGAAGCRGGGGERGPRWRRPWKLLALGLLSASSVLAAAPGAGAMSKEEKRRLGNQVLEMFDHAYSNYMDHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDTLDTLVVLNKTKEFEEAVKKVIKDVNLDNDIVVSVFETNIRVLGGLLGGHSVAIMLKDKGEYMQWYNGELLHMAKELGYKLLPAFNTTSGLPYPRVNLKFGVRHPEARTGTETDTCTACAGTLILEFAALSRFTGTSIFEEYARKALDFIWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMKYISQPPLLLDVHIHKPMLNARTWMDSLLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDMIFDIEDYIFTTEAHLLPLWLSTTNQTISKKNTTTEYTELDDSNFDWTCPNTQILFPNDPMFAQSIREPLKNVVDKSCPRSISRAEESLGTGPKPPLRARDFMASNPEHLEILKKMGVSLIHLKDGRVQLVQHAVQAASSLDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGMDLSKHKSGTRGFVATIKPYNGCSEITNPEAVKEKIALMQRGQCMFAEKARNIQKAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKNTDDITIPMLFLFNKEGNIILDAIREYEAVEVLLSDKAKDRDLEMENMDQKLSENDSHKQNSEEASSASQDVGAVSEEPEEGESSDVSDLDSLPPAQADTDSVSTSDQDSSIPGPGEAGAPEPACTQGDEQPQEQQTETESDSKVNWDNKVQPMESILADWNEDIEAFEMMEKDEL", "length": 933 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6AKY3-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "Edem3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEAGGGRGCGCRVPQRASWSLVAATAALYLMLATTVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATVFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRNISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSVDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRAAILKGKRIPSYIINSNPEVENEDQPSSENDSQNQSAEQMLPLPQTVGLADQESPGNPLESPSEPPSPADSEEAAGFAPSEQISSPTETQETAGLDGECTDLDNQLQDQPETEEDPSPNVSWGTKAQPMDSILADWNEDIEAFEMMEKDEL", "length": 948 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M2BEF7-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "edem3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MWMLHSATMLPAFWLLFFMGTCIRLSETMSRDEKSKLRIQVLEMFDHAYRNYMDHAYPADELMPLTCRGRVRGLEPSRGDVDDALGKFSLTLIDTLDTLALLNKTVEFEEAVRRVVKDVRLDNDIVVSVFETNIRVLGGLLGGHSMAVMLKENGQMVWYQNELLHMAKDLGLRLLPAFNTSSGLPYPRVNLRHGVHGPETRTGTETETCTACAGTIILEFAALSRFTGDPTFEAHARRALDFLWEKRQRNSNLVGTTINIHSGEWVRRDSGVGAGIDSYYEYLMKAYILLGDDQLLLRFNTHYASIMKYISQPPLLLDVHIHKPLLPARTWMDSLLAFFPGLQVLKGDIRPAIETHEMLYQVTKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATRDPYYLEVGRTVLENLNRFARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLFLLFAEEEDLPFNVEDYVFTTEAHLLPLSLSTASNSPAPPVINSVVIEELDDLNFEWTCPNTRLLFPDPAFPRNFREPIRSAVDKSCLRPIAHREPGMGRPPLRAQDFMANNPEHLELLRRMGVSLIHLKDGRVQLVQHATQAVSAVAAEDGMRFMQEMMELSSQQQKEQLPPRAVQIVSHPFFGRVVLTAGPAQFGMDLSKSSSGVRGFVTVAEPYNGCSELSNGEIVAGRIALLQRGQCMFAEKARHVQKAGAIGGIVIDDNEGSSSDTAPLFQMAGDGRNTDDVTLPLLFLFHKEGNILLEALKEYKEVEVLLSDKARDREAIFKGKALPGALLDGTTDGAEEEDCSTEERDHSSPAPSEPVDQSQVTTQEQTAGDSESVQPAEGLGSYVSVDAGEEPPADEDSNNQSVDSLMADWQEDLEAFKQMEKDEL", "length": 888 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q2HXL6-1", "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 3", "gene_name": "Edem3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKAGGCRGCGCRVPQRASWSLVAATAALCLVLATSVCTAGAAPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEHMQWYNDELLHMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNRSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIISHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPYNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREHEQVEVLLSDKARDRDPEMENEDQPSSENDSQNQSAEQMLSLSQTVDLADKESPEHPADSHSEASPSDSEEAAGFAPSEQISGSTENHETTSLDGECTDLDNQVQEQSETEEDSSPNVSWGTKAQPIDSILADWNEDIEAFEMMEKDEL", "length": 931 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZQ6-1", "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 3", "gene_name": "EDEM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL", "length": 932 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VK27-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "Edem2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTTSSESFVRGQRLMLIFLVAMCIVVACVLSTETTMPTQNMSNKERAELREEARDMFYHAYNAYMQNAYPADELMPLSCKGRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDSDIIVSVFETNIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSRELGYRLLPAFNTSTGIPHARVNLRLGMKDPMLKKSRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLGDDKYLARFNRHYNAVMKYVSEGPMLLDVLMHRPHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMHTFIPEAFTVDFQIHWGQHPLRPEFIESTYFLYRATGDHHYLQVGKKALKTLQQHAKVSCGYAAVNDVRTGKHEDRMDSFVLSETIKYLFLLFSDPQDLIINVDEFVFTTEAHLLPLSIAQLGNATFSFRQTDEHNVLDFMRTCPSSNRLFPEKVRKPLRNFITGSCPRTTAGKRLSALDFQASNADHLRAVYDMGITMVSVGDRSQGKVRLFHSFYNAKSHEEGEMGLQFMQEMLELTKMQSINQLAQLQAVAYATDENSQDWIALMAGPSHFSPELTGDQFVEGDVILAKPLRACDESLENAEEAKGKVLVAERGDCTFVSKARLAQKVGAAALIVCDNVPGSSGETQPMFAMSGDGKDDVLIPVVFMYSMEFGKLSAVMQRRKQPLRVRVMQMVEFKRWQLAKEQRQNQTASVAQKPEKEL", "length": 801 }, "evidence": [ { "id": "A0AAA9T1L5", "url": "https://omabrowser.org/oma/group/A0AAA9T1L5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "endoplasmic reticulum mannose trimming", "id": "GO:1904380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "ubiquitin-dependent glycoprotein ERAD pathway", "id": "GO:0097466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097466", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" }, { "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "id": "GO:0004571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004571", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 900, "end_pos": 902, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "56008", "name": "", "equation": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9U0J9-1", "G3MXQ8-1", "A0AAA9T1L5-1", "E1BI49-1", "E1BNG2-1", "E1B7B0-1" ], "evidence": [ { "id": "56008", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56008" } ] }, { "id": "56028", "name": "", "equation": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9U0J9-1", "G3MXQ8-1", "A0AAA9T1L5-1", "E1BI49-1", "E1BNG2-1", "E1B7B0-1" ], "evidence": [ { "id": "56028", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56028" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T1L5", "gene_name": "EDEM3", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" } ] } ] }, { "uniprot_ac": "A0AAA9U0J9", "gene_name": "LOC100336900", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "A0AAA9U0J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J9" } ] } ] }, { "uniprot_ac": "E1B7B0", "gene_name": "MAN1C1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B7B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7B0" } ] } ] }, { "uniprot_ac": "E1BI49", "gene_name": "MAN1A2", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1BI49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI49" } ] } ] }, { "uniprot_ac": "E1BNG2", "gene_name": "MAN1A1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1BNG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG2" } ] } ] }, { "uniprot_ac": "G3MXQ8", "gene_name": "MAN1B1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "G3MXQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXQ8" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" }, { "id": "PF02225", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PA", "eco_id": "ECO_0000259", "start_pos": 689, "end_pos": 774, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [ { "evidence": [ { "id": "A0A3Q1M3M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3M5#function" }, { "id": "A0A3Q1M3M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3M5" }, { "id": "PIRSR601382-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601382-2" } ], "binding_site_uniprot": 458, "amino_acid": "Arg", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 458, "end_pos": 458, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5#function" }, { "id": "A0AAA9T1L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1L5" }, { "id": "PIRSR601382-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601382-2" }, { "id": "A0AAA9TRR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR4#function" }, { "id": "A0AAA9TRR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR4" }, { "id": "E1B789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B789#function" }, { "id": "E1B789", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B789" } ], "binding_site_uniprot": 492, "amino_acid": "Thr", "chebi_lig_id": "CHEBI_29108", "ligand": "Ca(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 492, "end_pos": 492, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 812, "end_pos": 814 }, { "start_pos": 900, "end_pos": 902 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1N2-1", "uniprot_ac": "A0AAA9T1N2", "uniprot_id": "A0AAA9T1N2_BOVIN", "mass": { "chemical_mass": 16489.0, "monoisotopic_mass": 16489.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Large ribosomal subunit protein uL23", "type": "recommended", "evidence": [ { "id": "A0AAA9T1N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2/entry#names_and_taxonomy" } ] }, { "name": "60S ribosomal protein L23a", "type": "synonym", "evidence": [ { "id": "A0AAA9T1N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2#function" }, { "database": "UniProtKB", "id": "ARBA00045456", "url": "https://www.uniprot.org/uniprotkb/ARBA00045456#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2", "locus": {} } ], "crossref": [ { "id": "A0AAA9T1N2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1N2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00276", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00276", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03939", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03939", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII", "length": 146, "header": "tr|A0AAA9T1N2-1|A0AAA9T1N2_BOVIN Isoform 1 of Large ribosomal subunit protein uL23 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T1N2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2/entry#A0AAA9T1N2-1", "sequence": { "sequence": "MKMAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII", "length": 146, "header": "tr|A0AAA9T1N2-1|A0AAA9T1N2_BOVIN Isoform 1 of Large ribosomal subunit protein uL23 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T1N2-1" }, "locus": { "chromosome": "X", "start_pos": 80601774, "end_pos": 80601301, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110546.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110546.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092696.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092696.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "rRNA binding", "id": "GO:0019843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1N2" }, { "id": "PF03939", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03939" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL23 N-terminal", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 59, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1Q1-1", "uniprot_ac": "A0AAA9T1Q1", "uniprot_id": "A0AAA9T1Q1_BOVIN", "mass": { "chemical_mass": 36492.0, "monoisotopic_mass": 36492.0 }, "refseq": {}, "gene_names": [ { "name": "BLVRA", "type": "recommended", "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ] } ], "protein_names": [ { "name": "Biliverdin reductase A", "type": "recommended", "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1/entry#names_and_taxonomy" } ] }, { "name": "1.3.1.24", "type": "synonym", "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1/entry#names_and_taxonomy" } ] }, { "name": "Biliverdin-IX alpha-reductase", "type": "synonym", "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1#function" }, { "database": "UniProtKB", "id": "ARBA00058120", "url": "https://www.uniprot.org/uniprotkb/ARBA00058120#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BLVRA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1", "locus": { "chromosome": "4", "start_pos": 77284046, "end_pos": 77335575, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013414", "url": "https://www.ensembl.org/id/ENSBTAG00000013414" } ] } } ], "crossref": [ { "id": "A0AAA9T1Q1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1Q1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43377:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43377:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01408", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09166", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09166", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCCLAYFRPEATLFCKELLQKETKMNTEPERKFGVVVVGVGRAGSVRMRDLRNPHASSAFLNLIGFVSRRELGSIDEVPQISLEDALSSQEVEVAFICSESSSHEDYIRQFLNAGKHVLVEYPMTLSWVAAKDLWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAAPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETENKSPLTWIEEKAPGLKRNRRLSFHFRSGSLENMPNVGINKNIFLKDQNIFVQKLLGQFSEEELAAEKKRILHCLWLAGEIQKHCCSKQ", "length": 320, "header": "tr|A0AAA9T1Q1-1|A0AAA9T1Q1_BOVIN Isoform 1 of Biliverdin reductase A OS=Bos taurus OX=9913 GN=BLVRA PE=3 SV=1 CANONICAL=A0AAA9T1Q1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1Q1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1/entry#A0AAA9T1Q1-1", "sequence": { "sequence": "MCCLAYFRPEATLFCKELLQKETKMNTEPERKFGVVVVGVGRAGSVRMRDLRNPHASSAFLNLIGFVSRRELGSIDEVPQISLEDALSSQEVEVAFICSESSSHEDYIRQFLNAGKHVLVEYPMTLSWVAAKDLWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAAPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETENKSPLTWIEEKAPGLKRNRRLSFHFRSGSLENMPNVGINKNIFLKDQNIFVQKLLGQFSEEELAAEKKRILHCLWLAGEIQKHCCSKQ", "length": 320, "header": "tr|A0AAA9T1Q1-1|A0AAA9T1Q1_BOVIN Isoform 1 of Biliverdin reductase A OS=Bos taurus OX=9913 GN=BLVRA PE=3 SV=1 CANONICAL=A0AAA9T1Q1-1" }, "locus": { "chromosome": "4", "start_pos": 77331429, "end_pos": 77285502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092999.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092999.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091652.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "biliberdin reductase (NADH) activity", "id": "GO:0106276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106276", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "heme catabolic process", "id": "GO:0042167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042167", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1Q1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" }, { "id": "PF09166", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09166" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Biliverdin reductase catalytic", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 267, "start_aa": "Phe", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T1Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Q1" }, { "id": "PF01408", "database": "Pfam", "url": 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[provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377513" }, "gene_names": [ { "name": "OR52E1", "type": "recommended", "evidence": [ { "id": "A0AAA9T206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206" } ] }, { "name": "OR52E1", "type": "synonym", "evidence": [ { "id": "NP_001377513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377513" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 52E1", "type": "synonym", "evidence": [ { "id": "NP_001377513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377513" } ] }, { "name": "olfactory receptor family 52 subfamily E member 1", "type": "synonym", "evidence": [ { "id": "NP_001377513", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377513" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T206", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377513" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T206", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T206", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T206", "locus": { "chromosome": "15", "start_pos": 49835829, "end_pos": 49836773, 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"MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSIFQKLYDLYIEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNRQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQLKLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYIFECEAGNQYQKTKLTILQSLGDPLYYGKIQPCKEDEESDSPMSPSQFIIGSKTDAERVVSQYQELVQNEAKCPVKMSHSSSGSASLSQLSPGKETEQPETVSVQSSVLGKGVKHRPPPIKLPSTSGNSSSGNYFTPQQASSFLKSPTPPPASKPPSLSRKSSVDLNQVSMLSPAALSPASSSQRHES", "length": 525, "header": "tr|A0ABI0P684-1|A0ABI0P684_BOVIN Computationally mapped isoform of SPT20 homolog, SAGA complex component OS=Bos taurus OX=9913 GN=SUPT20H PE=3 SV=1 CANONICAL=A0AAA9T230-1" }, "locus": { "chromosome": "12", "start_pos": 24671440, "end_pos": 24648694, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152289.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152289.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106955.1" } ] } }, { "isoform_ac": "F1MFY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T230/entry#F1MFY8-1", "sequence": { "sequence": "MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSIFQKLYDLYIEECEKEPEVKQKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNRQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQLKLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYIFECEAGNQYQKTKLTILQSLGDPLYYGKIQPCKEDEESDSPMSPSHFSTDDHSNWFIIGSKTDAERVVSQYQELVQNEAKCPVKMSHSSSGSASLSQLSPGKETEQPETVSVQSSVLGKGVKHRPPPIKLPSTSGNSSSGNYFTPQQASSFLKSPTPPPASKPPSLSRKSSVDLNQVSMLSPAALSPASSSQRSGTPKPSTPTPTPSSTPHPPDAQSSTPITPSATPTPQDSGFTPQPTLLTQFAQQQKSLSQAMPVTTIPLSTMVTSITTGTTATQVMANSAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGVNLSGLLPSGGLLPNALPGAMQTASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQQQQQLSQFTPQQPQQPQQPTTSSPQQPGEQGSEQSLTSQEQALSAQHAAVINLAGVGSFMHSQAAAVTILAASNGYGSSSSTNSSATSSSAYRQPVKK", "length": 819, "header": "tr|F1MFY8-1|A0AAA9T230_BOVIN Computationally mapped isoform of SPT20 homolog, SAGA complex component OS=Bos taurus OX=9913 GN=SUPT20H PE=3 SV=2 CANONICAL=A0AAA9T230-1" }, "locus": { "chromosome": "12", "start_pos": 24685337, "end_pos": 24648694, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015749.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015749.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015749.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015749.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 494, "start_aa": "Thr", "end_pos": 494, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr494", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { 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"glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T230", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T230" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SAGA complex", "id": "GO:0000124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T230", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T230" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T230", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T230" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T230", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T230" }, { "id": "PF12090", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12090" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spt20-like SEP", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 216, "start_aa": "Cys", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 494, 541, 543, 560, 654 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 474, "end_pos": 476 }, { "start_pos": 659, "end_pos": 661 }, { "start_pos": 692, "end_pos": 694 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. 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"summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262" }, "gene_names": [ { "name": "OR51A5", "type": "recommended", "evidence": [ { "id": "A0AAA9T294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294" } ] }, { "name": "OR51A5", "type": "synonym", "evidence": [ { "id": "NP_001377262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 51A4", "type": "synonym", "evidence": [ { "id": "NP_001377262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262" } ] }, { "name": "olfactory receptor family 51 subfamily A member 5", "type": "synonym", "evidence": [ { "id": "NP_001377262", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T294", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T294", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294", "locus": { "chromosome": "15", "start_pos": 49985633, "end_pos": 49984692, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065883", "url": "https://www.ensembl.org/id/ENSBTAG00000065883" } ] } } ], "crossref": [ { "id": "A0AAA9T294", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T294", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782658", "url": "https://www.ncbi.nlm.nih.gov/gene/782658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782658", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782658", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377262", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T294", "url": 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"pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T294", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T294", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T294" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein 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Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. 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"start_pos": 25187052, "end_pos": 25144012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102588.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102588.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091149.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:519541", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519541", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q96EQ8-1", "protein_name": "E3 ubiquitin-protein ligase RNF125", "gene_name": "RNF125", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2C1-1", "uniprot_ac": "A0AAA9T2C1", "uniprot_id": "A0AAA9T2C1_BOVIN", "mass": { "chemical_mass": 20767.0, "monoisotopic_mass": 20767.0 }, "refseq": { "ac": "XP_005208776", "name": "trafficking protein particle complex subunit 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208776" }, "gene_names": [ { "name": "TRAPPC5", "type": "recommended", "evidence": [ { "id": "A0AAA9T2C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ] }, { "name": "TRAPPC5", "type": "synonym", "evidence": [ { "id": 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"ENSBTAG00000004268", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14943", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14943", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504874", "url": "https://www.ncbi.nlm.nih.gov/gene/504874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YMVKFDD", "url": "https://omabrowser.org/oma/group/YMVKFDD/", "database": "OMA", "categories": [ "Protein 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"header": "tr|A0AAA9T2C1-1|A0AAA9T2C1_BOVIN Isoform 1 of Trafficking protein particle complex subunit 5 OS=Bos taurus OX=9913 GN=TRAPPC5 PE=3 SV=1 CANONICAL=A0AAA9T2C1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2C1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1/entry#A0AAA9T2C1-1", "sequence": { "sequence": "MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188, "header": "tr|A0AAA9T2C1-1|A0AAA9T2C1_BOVIN Isoform 1 of Trafficking protein particle complex subunit 5 OS=Bos taurus OX=9913 GN=TRAPPC5 PE=3 SV=1 CANONICAL=A0AAA9T2C1-1" }, "locus": { "chromosome": "7", "start_pos": 16528234, "end_pos": 16527671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105499.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105499.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093790.1" } ] } }, { "isoform_ac": "A0AAA9TVN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1/entry#A0AAA9TVN3-1", "sequence": { "sequence": "MDGSQPGSSVLGILQGGGMEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 206, "header": "tr|A0AAA9TVN3-1|A0AAA9TVN3_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 5 OS=Bos taurus OX=9913 GN=TRAPPC5 PE=3 SV=1 CANONICAL=A0AAA9T2C1-1" }, "locus": { "chromosome": "7", "start_pos": 16528234, "end_pos": 16527299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102675.1" } ] } }, { "isoform_ac": "F1MSD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1/entry#F1MSD6-1", "sequence": { "sequence": "MEVLLAQSCRDSATPWMVASQAPLSLGFSRQSLYHLSHQGSPPLASLPSPLLDKGISLIREGGGMEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 252, "header": "tr|F1MSD6-1|A0AAA9T2C1_BOVIN Computationally mapped isoform of Trafficking protein particle complex subunit 5 OS=Bos taurus OX=9913 GN=TRAPPC5 PE=3 SV=2 CANONICAL=A0AAA9T2C1-1" }, "locus": { "chromosome": "7", "start_pos": 16528234, "end_pos": 16527255, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005590.5", "url": "https://www.ensembl.org/id/ENSBTAT00000005590.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005590.3", "url": "https://www.ensembl.org/id/ENSBTAP00000005590.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0KWV8-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "Trappc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEARFTRGKSALLERALVRPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SCJ1-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "TRAPPC5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HWW9-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "Trappc5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEARFTRGKSALLERALVRPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q03337-1", "protein_name": "Trafficking protein particle complex subunit 31", "gene_name": "TRS31", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQRIIQPSASDQQFPGKSDGYEYTVGPKQAITSEASTTYIPSRIYSESLLFKRQEASLSAMAFLFQEMISQLHRTCKTAGDFETKLSDYGHNIGIRLLELLNFRASVSPSSLPRASAFLSQNESSSKLSNASNSPGMLANSSTATSASANERLQEKQTESLSNYITKMRRRDLKILDILQFIHGTLWSYLFNHVSDDLVKSSERDNEYMIVDNFPTLTQFIPGENVSCEYFVCGIIKGFLFNAGFPCGVTAHRMPQGGHSQRTVYLIQFDRQVLDREGLRFG", "length": 283 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54YG5-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "trappc5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKAPVNIVDRPLSKGKGEINISSFAFLFSEMIQYCQDRIKAGHELEKKLSDMGYSIGPRLLELLCVREKNSKRETKLLGILSFIHTTVWKSLFGKPADSLEKSTEADDEYMISDNNMVVNKFISLPKHLSSLNCAAFVAGIIEGILCSAEFPARVTAHNVAVEGKRFPKTVILIKFNPEVIERNA", "length": 186 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8IUR0-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "TRAPPC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQSRLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQA1-1", "protein_name": "Trafficking protein particle complex subunit 5", "gene_name": "Trappc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEARFTRGKSALLERALVRPRTEVSLSAFALLFSELVQHCQSRVFSVAELQARLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR", "length": 188 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FGU1-1", "protein_name": "Trafficking protein particle complex subunit", "gene_name": "TRAPPC5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIGVGKMKQYSNVLDKPLSKGKQEVSLTAFAFLFSELVQYNQTQVDNIAELERRLEDAGYAVGSRVLELLCNREKGNRRETRLLGILSFVHSTVWKVLFGKVADSLEKGTEHEDEYMISEKELLVNRFISIPKDMGTFNCGAFVAGIVKGVLDNAGFPAVVTAHFVPIEGQQRPRTTILIKFADEVLKREARLSQ", "length": 195 }, "evidence": [ { "id": "A0AAA9T2C1", "url": "https://omabrowser.org/oma/group/A0AAA9T2C1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" }, { "name": "TRAPP complex", "id": "GO:0030008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" }, { "name": "TRAPPIII protein complex", "id": "GO:1990072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990072", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" }, { "name": "TRAPPI protein complex", "id": "GO:1990070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" }, { "name": "TRAPPII protein complex", "id": "GO:1990071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990071", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2C1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Golgi vesicle transport", "id": "GO:0048193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048193", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2C1", "url": 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"start_pos": 249, "end_pos": 251 }, { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2L5-1", "uniprot_ac": "A0AAA9T2L5", "uniprot_id": "A0AAA9T2L5_BOVIN", "mass": { "chemical_mass": 334362.0, "monoisotopic_mass": 334362.0 }, "refseq": {}, "gene_names": [ { "name": "SRCAP", "type": "recommended", "evidence": [ { "id": "A0AAA9T2L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ] } ], "protein_names": [ { "name": "Snf2 related CREBBP activator protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T2L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRCAP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5", "locus": { "chromosome": "25", "start_pos": 26861125, "end_pos": 26832559, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013917", "url": "https://www.ensembl.org/id/ENSBTAG00000013917" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013917", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013917", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18003", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18003", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18793", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18793", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45685", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45685", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45685:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45685:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N326", "url": "https://www.uniprot.org/uniprotkb/G3N326", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N326-1", "url": "https://www.uniprot.org/uniprotkb/G3N326-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSCPSPAHPQLPILQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGPPGPPDGATVPLEGLSLPQPTDLANRGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASAMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLASSKAGSSPCLGSSSAASSPPPPGSRMDDEDGDFQPQEEEEEDDEETIEVEEQQEGNDAETQRREIELLRREGELPLEELLRSLPPQLLGGPSSPSGTPSSHESDTRDGPEEGGEEEPSQVLKVKPPPSVTQRNKQPWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQRYAGAYASDASAPGSGSSEEEDEDEVEANSSDCEPEGATEAEEAPQEDSSSQSDSAEEQSEDEDEEHSEEEETSESSESEESESEESEESQSQSQADEEEEEDDDFGVEYLLARDEEQSEADGGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPQYRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNSPRTPLGPVPVRPPPGPELSAQPTPGPTPPVLPAPLMVSASPSGPPLIPASRPPGPVLLPPLQPNSGPLPQVLPSPLGVLSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSNLLKPLTVPPGYAFPNAAATTTSTSTVTAPTTAVPAPASAPQRLILSPDMQARLPSGEVVSIGQLASLTQRPVASTGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLTPRPTLPPGRLPTPSLGTARAPIPTSTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLPVPSSLPGPASSPVPVPNSSPLASPVSSTVSVPVSSSLPISVSTTLPSPASAPLTIPISAPLPVSASGPTLLTNVTPTLAPVVSAAPGPPSLAPVGASPSASALTLGLASTPSLSPSQAPGHPLLLAPASSHVPGLNSAVAPACSPVLVPASALANPFPATPNPAPAQASLLAPAPTASQALATSLAPMVAPQTAILAPSPAPPLAPLPVLAPSPGPTSVLASSQTSVPVLASSSTPGTPLASASSLGPAPAAALAPSSAQTMVPAPVPSPLPSPASTQTLALPPALASTLGGSSPSQTLSLGTGNPQSPFSAQTLSLTPASSLVPAPAQTLSLAPGPPLGPSQTLSLAPAPTLAPVSPMGPAPAHTLTLAPVSSSASLLAPASVQTLTLSPAQVPVPTLGPAAAQTLALAPASTQSPASQASSLVVSSSGAAPLPVTMVSRLPVSKDEPETLTLRSGPPSPPSTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAARQAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLARELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSGSSVPSAPDDEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFTAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDEVSCGTGGGSHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVTSTHHTRSTSTPPRCSPARERVPRPAPRPRPPPASAPAAIPAPIPVPISAPIPISAPNPVTMLPVHILPSPPLPSAQIPPSCSSACTPPPACTPPPAQTPPPAQTSLLTPSSPLLLGLPSVPMSPPVTNLPLGLGPEAELCAQAMASTESLELAMASSETSPITLVPPKDLLPVAVEILPVSEKNLSLTSSAPSPTLAAGSVPNGQEQEVPEPAEATILSVLPDGEEMPTCLSESNRLELPPSAASDEPLPEPLETDKNSEELVEAQTPTSTPEKPQELVSAEATAPSTSSSATSTPEGSSPARPPRRRTSADVEIRGQGAGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGTASTLVPGVSETGTSPGSPSARSMSGPESSPPTSGPCEVASPSTLPTPTQQPFIARRRIELGLTGGGSSENGEGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPLSTSKGKTNGADPVPGAETLIVSEPVLAPQLIPGPQPLGPQPVHRPEPIILSPVEKRRRGRPPKARDLPLPGTTSSPGDGNLESRTQPLPLPPPLPPLPSLLSCPTAAAASTVTTLTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSSSVLESCGLGKQRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGVRGRKSEGSMVVAVIQDDLDLADSGPGGFRIDISRGLIGSKTALDSAASRVSSSPSRD", "length": 3143, "header": "tr|A0AAA9T2L5-1|A0AAA9T2L5_BOVIN Isoform 1 of Snf2 related CREBBP activator protein OS=Bos taurus OX=9913 GN=SRCAP PE=3 SV=1 CANONICAL=A0AAA9T2L5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5/entry#A0AAA9T2L5-1", "sequence": { "sequence": "MQSCPSPAHPQLPILQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGPPGPPDGATVPLEGLSLPQPTDLANRGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASAMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLASSKAGSSPCLGSSSAASSPPPPGSRMDDEDGDFQPQEEEEEDDEETIEVEEQQEGNDAETQRREIELLRREGELPLEELLRSLPPQLLGGPSSPSGTPSSHESDTRDGPEEGGEEEPSQVLKVKPPPSVTQRNKQPWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQRYAGAYASDASAPGSGSSEEEDEDEVEANSSDCEPEGATEAEEAPQEDSSSQSDSAEEQSEDEDEEHSEEEETSESSESEESESEESEESQSQSQADEEEEEDDDFGVEYLLARDEEQSEADGGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPQYRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNSPRTPLGPVPVRPPPGPELSAQPTPGPTPPVLPAPLMVSASPSGPPLIPASRPPGPVLLPPLQPNSGPLPQVLPSPLGVLSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSNLLKPLTVPPGYAFPNAAATTTSTSTVTAPTTAVPAPASAPQRLILSPDMQARLPSGEVVSIGQLASLTQRPVASTGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLTPRPTLPPGRLPTPSLGTARAPIPTSTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLPVPSSLPGPASSPVPVPNSSPLASPVSSTVSVPVSSSLPISVSTTLPSPASAPLTIPISAPLPVSASGPTLLTNVTPTLAPVVSAAPGPPSLAPVGASPSASALTLGLASTPSLSPSQAPGHPLLLAPASSHVPGLNSAVAPACSPVLVPASALANPFPATPNPAPAQASLLAPAPTASQALATSLAPMVAPQTAILAPSPAPPLAPLPVLAPSPGPTSVLASSQTSVPVLASSSTPGTPLASASSLGPAPAAALAPSSAQTMVPAPVPSPLPSPASTQTLALPPALASTLGGSSPSQTLSLGTGNPQSPFSAQTLSLTPASSLVPAPAQTLSLAPGPPLGPSQTLSLAPAPTLAPVSPMGPAPAHTLTLAPVSSSASLLAPASVQTLTLSPAQVPVPTLGPAAAQTLALAPASTQSPASQASSLVVSSSGAAPLPVTMVSRLPVSKDEPETLTLRSGPPSPPSTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAARQAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLARELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSGSSVPSAPDDEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFTAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDEVSCGTGGGSHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVTSTHHTRSTSTPPRCSPARERVPRPAPRPRPPPASAPAAIPAPIPVPISAPIPISAPNPVTMLPVHILPSPPLPSAQIPPSCSSACTPPPACTPPPAQTPPPAQTSLLTPSSPLLLGLPSVPMSPPVTNLPLGLGPEAELCAQAMASTESLELAMASSETSPITLVPPKDLLPVAVEILPVSEKNLSLTSSAPSPTLAAGSVPNGQEQEVPEPAEATILSVLPDGEEMPTCLSESNRLELPPSAASDEPLPEPLETDKNSEELVEAQTPTSTPEKPQELVSAEATAPSTSSSATSTPEGSSPARPPRRRTSADVEIRGQGAGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGTASTLVPGVSETGTSPGSPSARSMSGPESSPPTSGPCEVASPSTLPTPTQQPFIARRRIELGLTGGGSSENGEGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPLSTSKGKTNGADPVPGAETLIVSEPVLAPQLIPGPQPLGPQPVHRPEPIILSPVEKRRRGRPPKARDLPLPGTTSSPGDGNLESRTQPLPLPPPLPPLPSLLSCPTAAAASTVTTLTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSSSVLESCGLGKQRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGVRGRKSEGSMVVAVIQDDLDLADSGPGGFRIDISRGLIGSKTALDSAASRVSSSPSRD", "length": 3143, "header": "tr|A0AAA9T2L5-1|A0AAA9T2L5_BOVIN Isoform 1 of Snf2 related CREBBP activator protein OS=Bos taurus OX=9913 GN=SRCAP PE=3 SV=1 CANONICAL=A0AAA9T2L5-1" }, "locus": { "chromosome": "25", "start_pos": 26860121, "end_pos": 26832768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135042.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135042.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089901.1" } ] } }, { "isoform_ac": "G3N326-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5/entry#G3N326-1", "sequence": { "sequence": "MQSCPSPAHPQLPILQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGPPGPPDGATVPLEGLSLPQPTDLANRGPKWEKSHAEIAEQAKHEAEIETRIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAKLRRIASAMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLNQPLASSKAGSSPCLGSSSAASSPPPPGSRMDDEDGDFQPQEEEEEDDEETIEVEEQQEGNDAETQRREIELLRREGELPLEELLRSLPPQLLGGPSSPSGTPSSHESDTRDGPEEGGEEEPSQVLKVKPPPSVTQRNKQPWHPDEDDEEFTANEDEAEDEEDTIAAEEQLEGEVDHAMELSELAREGELSMEELLQRYAGAYASDASAPGSGSSEEEDEDEVEANSSDCEPEGATEAEEAPQEDSSSQSDSAEEQSEDEDEEHSEEEETSESSESEESESEESEESQSQSQADEEEEEDDDFGVEYLLARDEEQSEADGGSGPPTPGPTTTLGPKKEITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATGHFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPQYRLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNSPRTPLGPVPVRPPPGPELSAQPTPGPTPPVLPAPLMVSASPSGPPLIPASRPPGPVLLPPLQPNSGPLPQVLPSPLGVLSGTSRPPTPTLSLKPAPPAPVRLSPAPPPGSSNLLKPLTVPPGYAFPNAAATTTSTSTVTAPTTAVPAPASAPQRLILSPDMQARLPSGEVVSIGQLASLTQRPVASTGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQMPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLTPRPTLPPGRLPTPSLGTARAPIPTSTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLPVPSSLPGPASSPVPVPNSSPLASPVSSTVSVPVSSSLPISVSTTLPSPASAPLTIPISAPLPVSASGPTLLTNVTPTLAPVVSAAPGPPSLAPVGASPSASALTLGLASTPSLSPSQAPGHPLLLAPASSHVPGLNSAVAPACSPVLVPASALANPFPATPNPAPAQASLLAPAPTASQALATSLAPMVAPQTAILAPSPAPPLAPLPVLAPSPGPTSVLASSQTSVPVLASSSTPGTPLASASSLGPAPAAALAPSSAQTMVPAPVPSPLPSPASTQTLALPPALASTLGGSSPSQTLSLGTGNPQSPFSAQTLSLTPASSLVPAPAQTLSLAPGPPLGPSQTLSLAPAPTLAPVSPMGPAPAHTLTLAPVSSSASLLAPASVQTLTLSPAQVPVPTLGPAAAQTLALAPASTQSPASQASSLVVSSSGAAPLPVTMVSRLPVSKDEPETLTLRSGPPSPPSTATSFSGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHPTFWTYTEAARQAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLARELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSGSSVPSAPDDEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFTAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDEVSCGTGGGSHRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVTSTHHTRSTSTPPRCSPARERVPRPAPRPRPPPASAPAAIPAPIPVPISAPIPISAPNPVTMLPVHILPSPPLPSAQIPPSCSSACTPPPACTPPPAQTPPPAQTSLLTPSSPLLLGLPSVPMSPPVTNLPLGLGPEAELCAQAMASTESLELAMASSETSPITLVPPKDLLPVAVEILPVSEKNLSLTSSAPSPTLAAGSVPNGQEQEVPEPAEATILSVLPDGEEMPTCLSESNRLELPPSAASDEPLPEPLETDKNSEELVEAQTPTSTPEKPQELVSAEATAPSTSSSATSTPEGSSPARPPRRRTSADVEIRGQGAGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGTASTLVPGVSETGTSPGSPSARSMSGPESSPPTSGPCEVASPSTLPTPTQQPFIARRRIELGLTGGGSSENGEGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPLSTSKGKTNGADPVPGAETLIVSEPVLAPQLIPGPQPLGPQPVHRPEPIILSPVEKRRRGRPPKARDLPLPGTTSSPGDGNLESRTQPLPLPPPLPPLPSLLSCPTAAAASTVTTLTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSSSVLESCGLGKQRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAEGVRGRKSEGSMVVAVIQDDLDLADSGPGGFRIDISRGLIGSKTALDSAASRVSSSPSRD", "length": 3081, "header": "tr|G3N326-1|G3N326_BOVIN Computationally mapped isoform of Snf2 related CREBBP activator protein OS=Bos taurus OX=9913 GN=SRCAP PE=3 SV=3 CANONICAL=A0AAA9T2L5-1" }, "locus": { "chromosome": "25", "start_pos": 26860121, "end_pos": 26832768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063921.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063921.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056298.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056298.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1043, "start_aa": "Thr", "end_pos": 1043, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1043", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1047, "start_aa": "Thr", "end_pos": 1047, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1047", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1272, "start_aa": "Thr", "end_pos": 1272, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1272", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1276, "start_aa": "Thr", "end_pos": 1276, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1276", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1361, "start_aa": "Thr", "end_pos": 1361, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1361", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1518, "start_aa": "Thr", "end_pos": 1518, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1518", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1584, "start_aa": "Thr", "end_pos": 1584, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1584", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1625, "start_aa": "Thr", "end_pos": 1625, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1625", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1643, "start_aa": "Thr", "end_pos": 1643, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1643", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 353, "start_aa": "Thr", "end_pos": 353, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr353", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 577, "start_aa": "Thr", "end_pos": 577, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr577", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 581, "start_aa": "Thr", "end_pos": 581, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr581", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 924, "start_aa": "Thr", "end_pos": 924, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr924", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "catalytic activity, acting on a protein", "id": "GO:0140096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "ATP-dependent chromatin remodeler activity", "id": "GO:0140658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140658", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "cAMP/PKA signal transduction", "id": "GO:0141156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": 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"expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8", "locus": { "chromosome": "10", "start_pos": 54365426, "end_pos": 54223817, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000565", "url": "https://www.ensembl.org/id/ENSBTAG00000000565" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000565", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000565", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541058", "url": "https://www.ncbi.nlm.nih.gov/gene/541058", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541058", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541058", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QCQENPD", "url": "https://omabrowser.org/oma/group/QCQENPD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFW7", "url": "https://www.orthodb.org/?gene=E1BFW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179749", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFW7", "url": "https://www.uniprot.org/uniprotkb/E1BFW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFW7-1", "url": "https://www.uniprot.org/uniprotkb/E1BFW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHRIKNSICKTIQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPPGIKGITQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKSEGSASNGVTNLSNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPASTSALTIRSPTTVLFTSSPIKTAVVPTSHMSSLNVVKMTAISLTPSSSSTPLKHSASANSATGTTEEARTIPQIKNGSVVSLQSPGSKTSSTGGPSAVEVKMEPETSSDEPPIQCQENSDGTDVPKTAPGALSGQKSNIDGAVQKPSNEGVVEIKATKVCDQRTKCKNRCNEILPGTSTGNNQSTVTLSVATQNFTFTSTSSPSNGDSINKDPKVCTKSPRKRLSSAMQESQVPPIKKPIVEQLSAVIPEGQKPGSVKKDPKVPHSGKTESSAAGAQISSKVSTHVNSHIVASQPLDPSALVTSDSALEQQTTPSSSPDIKVKLEGSVFLLDNDSKSDGSFNPNEWQQVTKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHGQIQESSLNQIQAQSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHASSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDSHFCRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILETSTVFPSANPQNMIDSSTSIYEFQAPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFSSTVKDLLSGDSLQTSQQLVGQVAPDLTNPASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEPTLEELKNDPLFQQICSDSMSSMTSSGFEWIESKDHPTVEMLG", "length": 1461, "header": "tr|A0AAA9T2M8-1|A0AAA9T2M8_BOVIN Isoform 1 of Regulatory factor X7 OS=Bos taurus OX=9913 GN=RFX7 PE=3 SV=1 CANONICAL=A0AAA9T2M8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2M8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8/entry#A0AAA9T2M8-1", "sequence": { "sequence": "MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHRIKNSICKTIQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPPGIKGITQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKSEGSASNGVTNLSNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPASTSALTIRSPTTVLFTSSPIKTAVVPTSHMSSLNVVKMTAISLTPSSSSTPLKHSASANSATGTTEEARTIPQIKNGSVVSLQSPGSKTSSTGGPSAVEVKMEPETSSDEPPIQCQENSDGTDVPKTAPGALSGQKSNIDGAVQKPSNEGVVEIKATKVCDQRTKCKNRCNEILPGTSTGNNQSTVTLSVATQNFTFTSTSSPSNGDSINKDPKVCTKSPRKRLSSAMQESQVPPIKKPIVEQLSAVIPEGQKPGSVKKDPKVPHSGKTESSAAGAQISSKVSTHVNSHIVASQPLDPSALVTSDSALEQQTTPSSSPDIKVKLEGSVFLLDNDSKSDGSFNPNEWQQVTKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHGQIQESSLNQIQAQSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHASSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDSHFCRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILETSTVFPSANPQNMIDSSTSIYEFQAPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFSSTVKDLLSGDSLQTSQQLVGQVAPDLTNPASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEPTLEELKNDPLFQQICSDSMSSMTSSGFEWIESKDHPTVEMLG", "length": 1461, "header": "tr|A0AAA9T2M8-1|A0AAA9T2M8_BOVIN Isoform 1 of Regulatory factor X7 OS=Bos taurus OX=9913 GN=RFX7 PE=3 SV=1 CANONICAL=A0AAA9T2M8-1" }, "locus": { "chromosome": "10", "start_pos": 54362535, "end_pos": 54224948, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103941.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103941.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091988.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091988.1" } ] } }, { "isoform_ac": "E1BFW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8/entry#E1BFW7-1", "sequence": { "sequence": "MSPRRQAKATHSSPGRWQRNNNSRHHSSLMPISSFPPAPPTRGWLCQPLCPGCQGQRPARCNTGSRTPSAKLYNLRWTAFCDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPPGIKGITQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKSEGSASNGVTNLSNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPASTSALTIRSPTTVLFTSSPIKTAVVPTSHMSSLNVVKMTAISLTPSSSSTPLKHSASANSATGTTEEARTIPQIKNGSVVSLQSPGSKTSSTGGPSAVEVKMEPETSSDEPPIQCQENSDGTDVPKTAPGALSGQKSNIDGAVQKPSNEGVVEIKATKVCDQRTKCKNRCNEILPGTSTGNNQSTVTLSVATQNFTFTSTSSPSNGDSINKDPKVCTKSPRKRLSSAMQESQVPPIKKPIVEQLSAVIPEGQKPGSVKKDPKVPHSGKTESSAAGAQISSKVSTHVNSHIVASQPLDPSALVTSDSALEQQTTPSSSPDIKVKLEGSVFLLDNDSKSDGSFNPNEWQQVTKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHGQIQESSLNQIQAQSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHASSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDSHFCRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILETSTVFPSANPQNMIDSSTSIYEFQAPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFSSTVKDLLSGDSLQTSQQLVGQVAPDLTNPASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEPTLEELKNDPLFQQICSDSMSSMTSSGFEWIESKDHPTVEMLG", "length": 1449, "header": "tr|E1BFW7-1|A0AAA9T2M8_BOVIN Computationally mapped isoform of Regulatory factor X7 OS=Bos taurus OX=9913 GN=RFX7 PE=3 SV=3 CANONICAL=A0AAA9T2M8-1" }, "locus": { "chromosome": "10", "start_pos": 54362535, "end_pos": 54224753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000738.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000738.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000738.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000738.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 921, "start_aa": "Thr", "end_pos": 921, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr921", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 952, "start_aa": "Thr", "end_pos": 952, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr952", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 954, "start_aa": "Thr", "end_pos": 954, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr954", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 956, "start_aa": "Thr", "end_pos": 956, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr956", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 958, "start_aa": "Thr", "end_pos": 958, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr958", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 960, "start_aa": "Thr", "end_pos": 960, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr960", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 962, "start_aa": "Thr", "end_pos": 962, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr962", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 964, "start_aa": "Thr", "end_pos": 964, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr964", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:541058", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541058", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9PT49-1", "protein_name": "Regulatory factor X, 7", "gene_name": "Rfx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEEQQQPPPQQLDAHQQLPLSAPNPGVALPALVPGLPGTEASALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSSAEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGVEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELAHFLVKSHYIGTKSMAALTVMAAAPAGLKGISQPSAFIPTAESNSFQPQVKTLSSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKTEGTTANGVANLPNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMNSSDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNAPLKHSASVSNATGTTEDSRSIPQIKNGSVVSLQSPGSRASSTGGTSAVEVKMEPEGSSDEHPLQCQENAEGTKAPLATSSALWGQKSNTDGTVSKPSNEGVTEVKTTKVCDQRAKCKSRCNETLPGISAGNNQSTVTLSVATQNLPFTSTSSPSNGDSVNKDPKLCTKSPRKRLSATLQESQVPPVKKPIVEQLSAVTTEGQKPGTVKKDQKVPHSGKTESSTAGAQPPNKVSLSVSSHIVEDQPLNPTLVASESALEQQTTPSSSPDVKVKLEGSVFLLDRESNSDGSFNRNEWQQVTKDSDFISASCEQQQDISVMTIPEHPDIHDLEKSVWELEGMPQDTYSQQLHSQIPESSLNEIQAQSSDQLPLQSELKEFESSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHGSSSHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYGGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNVPSNYTARMNLTQILETSPVFPSANSQNMIDSSTSVYEFQTPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDNLQTSQQLGGQVASDLTNTASDFPSDIRLSSDLSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG", "length": 1459 }, "evidence": [ { "id": "A0AAA9T2M8", "url": "https://omabrowser.org/oma/group/A0AAA9T2M8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8VPJ6-1", "protein_name": "DNA-binding protein RFX7", "gene_name": "Rfx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEEQQQPPPQQLDAPQQLPLSAPNPGVALPALVPGLPGTEANALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSSAEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGVEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELAHFLVKSHYIGTKSMAALTVMAAAPAGLKGIPQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESSAKKPEGTTANGVANLPNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMNSPDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNAPLKHSASVSSATGTTEESRIVPQIKNGSVVSLQSPGSRASSTGGTSAVEVKMEPEGSSDEHPLQCQENSEETKAPLTTSSALWGQKSNTDGTVPKPSNEGVTEVKTTKVCDQRTKCKNRCNEILSGISAGNNQSTVTLSVATQNLPFTSTSSPSNGDSVNKDPKICTKSPRKRLSATLQESQVPPVKKPIVEQLSAVTIEGQKPGTVKKDQKVPHSGKTESSTAGAQIPNKVSISVSSQIIEDQPVNPALVTSEPVLEQQTTPSSSPDVKVKLEGSVFLLDRESKSDGSFNRNEWQQVTKDSDFIAASCEHQQDISVMTIAEHPDIHDLEKSVWELEGMPQDTYSQQLHSQIPESSLNEIQAQSSDQLPLQSELKEFESSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMSLQNQSVTPGAPMSSHASSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYGGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNTNKQEGFAVPAPLDNKGTNSSAGSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDSVRGLGINNVPSNYTARMNLTQILETSPVFPSANSQNMIDSSTSVYEFQTPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDNLQTSQQLVGQVASDLTNTASDFSSDIRLSSDLSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG", "length": 1459 }, "evidence": [ { "id": "A0AAA9T2M8", "url": "https://omabrowser.org/oma/group/A0AAA9T2M8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3GRK9-1", "protein_name": "DNA-binding protein RFX7 isoform X1", "gene_name": "Rfx7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEEQQQPPPQQPDAHQQLPLSAPNPGVALPALVPGLPGTEANALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSSAEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGVEPSAQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELAHFLVKSHYIGTKSMAALTVMAAAPAGLKGIPQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGDASAKKTEGTTANGVSNLPNGNPAILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSPDGKVLPLNVQVVTQHMQSVKQTPKTPQNVPASPGGDRSARHRYPQILPKPANSSALTIRSPTTVLFTSSPIKTAVVPASHVSSLNVVKMTTISLTPSNNNAPLKQSASASSASGTTEESKSIPQIKNGSVVSLQSPGSRASNAGGTSAVEVKMEPEGSSDEHPLQCQENSEESKAPLTTPSALWGQKSNTDGAVPKPSNEGVIEVKATKVCDQRTKCKSRCNEILPGIPAGNNQSTVTLSVATQNLPFTSTSSPSNGDSVNKDSKLCTKSPRKRLSATLQESQVPPVKKPIVEQLSAVTIEGQKPGTVKKDQKVPHSGKTESSTAGAQIPNKVSISVSSHILEDQPLNPTLVASESVLEQQTTPSSSPDVKVKLEGSVFLLDHESKSDGSFNPSEWQQVTKDSDFIAASCEQQQDVSVMTIPEHSDIHDLEKSVWELEGMPQDTYSQQLHSRIPESSLNQIQAQSSDQLPLQSELKEFESSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMSLQSQSVTPGAPMSSHASSAHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYGGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNTNKQEGFAVPAPLDNKGTNSSASNTFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQTNSKKITNVLLSKLDSDNDDAVRGLGMNNMPSNYTARMNLTQILETSPVFPSANSQNMIDSSTSVYEFQTPSYLTKSNSTDQISFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDNLQTSQQLGGQVASDLTNTASDFPSDIRLSTDLSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDQPTVEMLG", "length": 1459 }, "evidence": [ { "id": "A0AAA9T2M8", "url": "https://omabrowser.org/oma/group/A0AAA9T2M8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q2KHR2-3", "protein_name": "DNA-binding protein RFX7", "gene_name": "RFX7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEQQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHKIKNSICKTVQSKVDCILQEVEKFTDLEKLYLYLQLPSGLSNGEKSDQNAMSSSRAQQMHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRGKSKYCYSGLRKKAFVHMPTLPNLDFHKTGDGLEGAEPSGQLQNIDEEVISSACRLVCEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGITQPSAFIPTAESNSFQPQVKTLPSPIDAKQQLQRKIQKKQQEQKLQSPLPGESAAKKSESATSNGVTNLPNGNPSILSPQPIGIVVAAVPSPIPVQRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQAPKTPQNVPASPGGDRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVVKMTTISLTPSNSNTPLKHSASVSSATGTTEESRSVPQIKNGSVVSLQSPGSRSSSAGGTSAVEVKVEPETSSDEHPVQCQENSDEAKAPQTPSALLGQKSNTDGALQKPSNEGVIEIKATKVCDQRTKCKSRCNEMLPGTSTGNNQSTITLSVASQNLTFTSSSSPPNGDSINKDPKLCTKSPRKRLSSTLQETQVPPVKKPIVEQLSAATIEGQKQGSVKKDQKVPHSGKTEGSTAGAQIPSKVSVNVSSHIGANQPLNSSALVISDSALEQQTTPSSSPDIKVKLEGSVFLLDSDSKSVGSFNPNGWQQITKDSEFISASCEQQQDISVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHSQIQESSLNQIQAHSSDQLPLQSELKEFEPSVSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPMSSHTSSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPVDSALGSSRHTPIGTPHSNCSSSVPPSPVECRNPFAFTPISSSMAYHDASIVSSSPVKPMQRPMATHPDKTKLEWMNNGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVPGQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNKGTNSSASSNFRCRSVSPAVHRQRNLSGSTLYPVSNIPRSNVTPFGSPVTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQANSKKITNVLLSKLDSDNDDAVRGLGMNNLPSNYTARMNLTQILEPSTVFPSANPQNMIDSSTSVYEFQTPSYLTKSNSTGQINFSPGDNQAQSEIGEQQLDFNSTVKDLLSGDSLQTNQQLVGQGASDLTNTASDFSSDIRLSSELSGSINDLNTLDPNLLFDPGRQQGQDDEATLEELKNDPLFQQICSESMNSMTSSGFEWIESKDHPTVEMLG", "length": 1460 }, "evidence": [ { "id": "A0AAA9T2M8", "url": "https://omabrowser.org/oma/group/A0AAA9T2M8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" }, { "name": "RNA polymerase II core promoter sequence-specific DNA binding", "id": "GO:0000979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000979", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2M8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1009, "end_pos": 1011, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1075, "end_pos": 1077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1136, "end_pos": 1138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1156, "end_pos": 1158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1177, "end_pos": 1179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1193, "end_pos": 1195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1277, "end_pos": 1279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1283, "end_pos": 1285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1322, "end_pos": 1324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" }, { "start_pos": 770, "end_pos": 772, "annotation": "n_glycosylation_sequon" }, { "start_pos": 873, "end_pos": 875, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" }, { "start_pos": 942, "end_pos": 944, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2M8" }, { "id": "PS51526", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51526" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RFX-type winged-helix", "eco_id": "ECO_0000259", "start_pos": 108, "end_pos": 183, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 921, 952, 954, 956, 958, 960, 962, 964 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1009, "end_pos": 1011 }, { "start_pos": 1075, "end_pos": 1077 }, { "start_pos": 1136, "end_pos": 1138 }, { "start_pos": 1156, "end_pos": 1158 }, { "start_pos": 1177, "end_pos": 1179 }, { "start_pos": 1193, "end_pos": 1195 }, { "start_pos": 1277, "end_pos": 1279 }, { "start_pos": 1283, "end_pos": 1285 }, { "start_pos": 1322, "end_pos": 1324 }, { "start_pos": 343, "end_pos": 345 }, { "start_pos": 513, "end_pos": 515 }, { "start_pos": 619, "end_pos": 621 }, { "start_pos": 631, "end_pos": 633 }, { "start_pos": 770, "end_pos": 772 }, { "start_pos": 873, "end_pos": 875 }, { "start_pos": 902, "end_pos": 904 }, { "start_pos": 942, "end_pos": 944 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T2N9-1", "uniprot_ac": "A0AAA9T2N9", "uniprot_id": "A0AAA9T2N9_BOVIN", "mass": { "chemical_mass": 69867.0, "monoisotopic_mass": 69867.0 }, "refseq": { "ac": "XP_005222648", "name": "EPM2A-interacting protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222648" }, "gene_names": [ { "name": "EPM2AIP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T2N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" } ] }, { "name": "EPM2AIP1", "type": "synonym", "evidence": [ { "id": "XP_005222648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222648" } ] } ], "protein_names": [ { "name": "EPM2A interacting protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T2N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9/entry#names_and_taxonomy" } ] }, { "name": "EPM2A-interacting protein 1", "type": "synonym", "evidence": [ { "id": "XP_005222648", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222648" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPM2AIP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9", "locus": { "chromosome": "22", "start_pos": 10559027, "end_pos": 10550292, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055342", "url": "https://www.ensembl.org/id/ENSBTAG00000055342" } ] } } ], "crossref": [ { "id": "A0AAA9T2N9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T2N9", "database": "AlphaFoldDB", "categories": [] }, { "id": "540067", "url": "https://www.ncbi.nlm.nih.gov/gene/540067", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540067", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540067", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HGERING", "url": "https://omabrowser.org/oma/group/HGERING/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45913:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45913:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18658", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18658", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005222648", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWMTPKRSKMEIDESRAFRAEWTQRYLVVEPPEGEGALCLVCRRLVAATGELDVKQHYEAEHEYYERYVTEDERAALVERLRRGDFPEAAPLTPEQRIARAGLGLARLLALKGCGWGEGDFVHRCMAVMLRDVLPDHVGIMDGIDLSPETTRQRVLDIHQNLRSQLFNRAKDFKAYSLALDDQAFVAYENYLLVFVRGVGHDLEVHEELLTIINLTHHFSVGALMAAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINAVSEWIVLIKTRGVRRPEFQALLTESESEHGERVNGRCLNNWLRKGKTLKLIFSLRKEIETFLVSIGATTVHFTDKEWLCDFGFLVDIMDHLREISELLRVSKVFAAAAFDHICAFEVKLNLLQRQVEEKNLTHFASLSQVVDELKENLQEDEKVLDLERYRAVICRLQKEFERHFKDLKFIKKDLELFANPFSFKPEYAPISVRVELTKLQASANLWEEYRTKDLGQFYAGLPAESYPIIKGVACKVASLFDSSKICEKAFSYLTRNQHTLSQPLTDEHLHALFRIATTEIEPRWDDLVRGRNESHP", "length": 608, "header": "tr|A0AAA9T2N9-1|A0AAA9T2N9_BOVIN Isoform 1 of EPM2A interacting protein 1 OS=Bos taurus OX=9913 GN=EPM2AIP1 PE=4 SV=1 CANONICAL=A0AAA9T2N9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9/entry#A0AAA9T2N9-1", "sequence": { "sequence": "MWMTPKRSKMEIDESRAFRAEWTQRYLVVEPPEGEGALCLVCRRLVAATGELDVKQHYEAEHEYYERYVTEDERAALVERLRRGDFPEAAPLTPEQRIARAGLGLARLLALKGCGWGEGDFVHRCMAVMLRDVLPDHVGIMDGIDLSPETTRQRVLDIHQNLRSQLFNRAKDFKAYSLALDDQAFVAYENYLLVFVRGVGHDLEVHEELLTIINLTHHFSVGALMAAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINAVSEWIVLIKTRGVRRPEFQALLTESESEHGERVNGRCLNNWLRKGKTLKLIFSLRKEIETFLVSIGATTVHFTDKEWLCDFGFLVDIMDHLREISELLRVSKVFAAAAFDHICAFEVKLNLLQRQVEEKNLTHFASLSQVVDELKENLQEDEKVLDLERYRAVICRLQKEFERHFKDLKFIKKDLELFANPFSFKPEYAPISVRVELTKLQASANLWEEYRTKDLGQFYAGLPAESYPIIKGVACKVASLFDSSKICEKAFSYLTRNQHTLSQPLTDEHLHALFRIATTEIEPRWDDLVRGRNESHP", "length": 608, "header": "tr|A0AAA9T2N9-1|A0AAA9T2N9_BOVIN Isoform 1 of EPM2A interacting protein 1 OS=Bos taurus OX=9913 GN=EPM2AIP1 PE=4 SV=1 CANONICAL=A0AAA9T2N9-1" }, "locus": { "chromosome": "22", "start_pos": 10559027, "end_pos": 10558388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124081.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124081.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089921.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089921.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540067", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540067", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1U2E1-1", "protein_name": "EPM2A interacting protein 1", "gene_name": "EPM2AIP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWMTPKRSKMEIEEPRGFQAEWTQRYLVVEPPEGEGALCLVCRRLVVANGEPDVRHHYEAEHDYYERYVAEGERAALVERLRQGDLPDAAPLTPEERAARAGLGLTRLLALKGRGWGEGDFVYRCMEVMLRDVLPDHVGVMDGIDLSPEITQQRVLDINQNLRSQLFNRAKDFKAYSLALDDQAFVAYENYLLVFVRGVGHDLEVQEELLTIINLTQHFSVGALMAAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINAISEWIVLIKTRGVRRPEFQALLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEIKTFLVSIGATTVHFTDKQWLCDFGFLVDIMDHLRELSELLRVSKVFAAAAFDHICTFEVKLNLLQRHIEEKNLTHFAALREVVDELKEHLQEDEKILDPERYQVVICRLQKEFERHFKDLKFIKKDLELFANPFSFKAEYAPISVRVELTKLQANTNLWNEYRTKDLGQFYAGLSAESYPIIKGVACKVASLFDSSKICEKAFSYLTRNQHTLSHPLTDEHLHALFRIATTEIEPQWDDLVRGRNESNP", "length": 608 }, "evidence": [ { "id": "A0AAA9T2N9", "url": "https://omabrowser.org/oma/group/A0AAA9T2N9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1M471-1", "protein_name": "EPM2A interacting protein 1", "gene_name": "Epm2aip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRRLVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLAAVLTPEERATRAGLGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDSNLRSQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGRDLEVQEDLLTIINLTHHFSVGALMSAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQSLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYLREISEELQISKVFAAAAFERICTFEDKLSSLQRHMEEVNLTDFPAFSIIVDELKQQFKEDQKIFDPDRYQMVISRLQKDFERHFKDLRFIKKDLELFSNPFSFKPEYAPISVRVELTKLQGNTDLWNEYRVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFAYLTRNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS", "length": 606 }, "evidence": [ { "id": "A0AAA9T2N9", "url": "https://omabrowser.org/oma/group/A0AAA9T2N9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HTA6-1", "protein_name": "EPM2A-interacting protein 1", "gene_name": "Epm2aip1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRRLVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLASVLTPEERATRAGLGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDSNLRGQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGHDLQVQEDLLTIINLTHHFSVGALMAAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQPLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYLREISEELQISKVFAAAAFDRICTFEAKLSSLQRHMEEVNLEDFPAFSIIVDELKQQFKEDQKIFDPDRYQMVISRLLKDFERHFKDLRFIKKDLELFANPFSFKPEYAPISVRVELTKLQGNTDLWNEYQVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFSYLTRNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS", "length": 606 }, "evidence": [ { "id": "A0AAA9T2N9", "url": "https://omabrowser.org/oma/group/A0AAA9T2N9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7L775-1", "protein_name": "EPM2A-interacting protein 1", "gene_name": "EPM2AIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWMTPKRSKMEVDEALVFRPEWTQRYLVVEPPEGDGALCLVCRRLIVATRERDVRRHYEAEHEYYERYVADGERAALVERLRQGDLPVASFTPEERAARAGLGLCRLLALKGRGWGEGDFVYQCMEVLLREVLPEHVSVLQGVDLSPDITRQRILSIDRNLRNQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGPELEVQEDLLTIINLTHHFSVGALMSAILESLQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDVNQIINTISEWIVLIKTRGVRRPEFQTLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEMEAFLVSVGATTVHFSDKQWLCDFGFLVDIMEHLRELSEELRVSKVFAAAAFDHICTFEVKLNLFQRHIEEKNLTDFPALREVVDELKQQNKEDEKIFDPDRYQMVICRLQKEFERHFKDLRFIKKDLELFSNPFNFKPEYAPISVRVELTKLQANTNLWNEYRIKDLGQFYAGLSAESYPIIKGVACKVASLFDSNQICEKAFSYLTRNQHTLSQPLTDEHLQALFRVATTEMEPGWDDLVRERNESNP", "length": 607 }, "evidence": [ { "id": "A0AAA9T2N9", "url": "https://omabrowser.org/oma/group/A0AAA9T2N9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VEH5-1", "protein_name": "EPM2A-interacting protein 1", "gene_name": "Epm2aip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWMTPKRIRMEVDEALVFRPEWTQRYLVVEPAEGDGALCLVCRRLVASTRERDVRRHYEAEHEFYERFVGDEERAALVERLRQGDMSLAAVLTPEERATRAGLGLCRFLALKGRGWGEGDFVHQCMEVLLREVLPDHVGVLEGIDLSPEITRQRILSIDSNLRSQLFNRARDFKAYSLALDDQAFVAYENYLLVFIRGVGRDLEVQEDLLTIINLTHHFSVGALMSAILEALQTAGLSLQRMVGLTTTHTLRMIGENSGLVSYMREKAVSPNCWNVIHYSGFLHLELLSSYDVDINQIINTISEWVVMIKTRGVRRPEFQPLLTESESEHGERVNGRCLNNWLRRGKTLKLIFSLRKEIEAFLVSVGATTVHFSDKQWLCDFGFLVDIMDYLREISEELQISKVFAAAAFERICTFEGKLSSLQRHMEEVNLTDFPAFSIIVDELKQQFKEDQKIFDPDRYQMVISRLQKDFERHFKDLRFIKKDLELFSNPFSFKPEYAPISVRVELTKLQANTDLWNEYRVKDLGQFYAGLSGEAYPIIKGVAYKVASLFDSNQICDKAFAYLTRNQHTLSQPLTDEHLQALFRVATTEMDPRWDDLVRERNDS", "length": 606 }, "evidence": [ { "id": "A0AAA9T2N9", "url": "https://omabrowser.org/oma/group/A0AAA9T2N9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasmic side of endoplasmic reticulum membrane", "id": "GO:0098554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2N9" }, { "id": "PF18658", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18658" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SPIN-DOC-like zinc-finger", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 75, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 604, "end_pos": 606 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF24857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214362", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214362", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE1", "url": "https://www.uniprot.org/uniprotkb/F1MBE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE1-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHFKRCQLLKQIAQKCLSRIHVKTDKHPQLFLSRTFALAELRKSWHSIYSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDIVSRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDTRVFCESGASPEEVANKVLSAVKRYQDVASETFISTRHIWPKDCEQKIPAKFFSEAVIEGLASDGGLFVPEKEFPKLNCGEWKSLVGATYIERAQILLEKCIHPADIPAAKLGEMIETAYGENFTCSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPHLFAHCIPPSCNFMILVATSGDTGSAVLNGFSRLNKNDKQRIAVATFFPEDGVSDFQKAQIIGSQNENGWAVGVKSDFDFCQTSIKRIFQDSDFTGFLAVEYGTVLSSANSINWGRLLPQVVYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKTMGVPIRKFICASNQNHVLTDFIKTGHYDIRERKLARTFSPAIDILKSSNLERHLHLMANKDGQLMRRLFNQLEEEHHFQIEKILVEKLQQDFVADWCSEGECLAAIHSTYNTSGYILDPHTAIAKVVADRMQDKTCPVIVSSTAHYSKFAPAIMQALKIREINQTSSSQVYLLSSYNALPPPHEALLERTKQQEKMEHQVCVADVNVLKNYVEKLAQNQFIGKFSE", "length": 748, "header": "tr|A0AAA9T2U9-1|A0AAA9T2U9_BOVIN Isoform 1 of Threonine synthase like 1 OS=Bos taurus OX=9913 GN=THNSL1 PE=3 SV=1 CANONICAL=A0AAA9T2U9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9/entry#A0AAA9T2U9-1", "sequence": { "sequence": "MLHFKRCQLLKQIAQKCLSRIHVKTDKHPQLFLSRTFALAELRKSWHSIYSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDIVSRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDTRVFCESGASPEEVANKVLSAVKRYQDVASETFISTRHIWPKDCEQKIPAKFFSEAVIEGLASDGGLFVPEKEFPKLNCGEWKSLVGATYIERAQILLEKCIHPADIPAAKLGEMIETAYGENFTCSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPHLFAHCIPPSCNFMILVATSGDTGSAVLNGFSRLNKNDKQRIAVATFFPEDGVSDFQKAQIIGSQNENGWAVGVKSDFDFCQTSIKRIFQDSDFTGFLAVEYGTVLSSANSINWGRLLPQVVYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKTMGVPIRKFICASNQNHVLTDFIKTGHYDIRERKLARTFSPAIDILKSSNLERHLHLMANKDGQLMRRLFNQLEEEHHFQIEKILVEKLQQDFVADWCSEGECLAAIHSTYNTSGYILDPHTAIAKVVADRMQDKTCPVIVSSTAHYSKFAPAIMQALKIREINQTSSSQVYLLSSYNALPPPHEALLERTKQQEKMEHQVCVADVNVLKNYVEKLAQNQFIGKFSE", "length": 748, "header": "tr|A0AAA9T2U9-1|A0AAA9T2U9_BOVIN Isoform 1 of Threonine synthase like 1 OS=Bos taurus OX=9913 GN=THNSL1 PE=3 SV=1 CANONICAL=A0AAA9T2U9-1" }, "locus": { "chromosome": "13", "start_pos": 25853832, "end_pos": 25851589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135686.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135686.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100833.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100833.1" } ] } }, { "isoform_ac": "F1MBE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9/entry#F1MBE1-1", "sequence": { "sequence": "MLHFKRCQLLKQIAQKCLSRIHVKTDKHPQLFLSRTFALAELRKSWHSIYSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDIVSRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDTRVFCESGASPEEVANKVLSAVKRYQDVASETFISTRHIWPKDCEQKIPAKFFSEAVIEGLASDGGLFVPEKEFPKLNCGEWKSLVGATYIERAQILLEKCIHPADIPAAKLGEMIETAYGENFTCSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPHLFAHCIPPSCNFMILVATSGDTGSAVLNGFSRLNKNDKQRIAVATFFPEDGVSDFQKAQIIGSQNENGWAVGVKSDFDFCQTSIKRIFQDSDFTGFLAVEYGTVLSSANSINWGRLLPQVVYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKTMGVPIRKFICASNQNHVLTDFIKTGHYDIRERKLARTFSPAIDILKSSNLERHLHLMANKDGQLMRRLFNQLEEEHHFQIEKILVEKLQQDFVADWCSEGECLAAIHSTYNTSGYILDPHTAIAKVVADRMQDKTCPVIVSSTAHYSKFAPAIMQALKIREINQTSSSQVYLLSSYNALPPPHEALLERTKQQEKMEHQSTS", "length": 724, "header": "tr|F1MBE1-1|A0AAA9T2U9_BOVIN Computationally mapped isoform of Threonine synthase like 1 OS=Bos taurus OX=9913 GN=THNSL1 PE=3 SV=4 CANONICAL=A0AAA9T2U9-1" }, "locus": { "chromosome": "13", "start_pos": 25857820, "end_pos": 25851589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012015.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012015.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012015.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012015.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788561", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788561", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XEU1-1", "protein_name": "Threonine synthase like 1", "gene_name": "THNSL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFHIVQYRPLRLITQNSLSKICLKLMFSRLVTFEWIPKSWFSSHSLVGNKNIILMGPPGAGKTTVGRIVGQKLDCPVIDIDDDVLETTWNMSVSEKLQDVGNEQFLEEEGKALLKFSASGSVISLTGSNPMHTAGMQHVKRNGIVVYLDVPTVVIMSRLKSMKVDRIVGQGPATSLKDILQFRKQFYKRWYDVRVLCGGNMAAEIVAEKVLDAVKRYQNSEVETYVSTRSTQKNSHKYFSDVVVEGLASDGGLFVPERGLPEFTAEEWQTLIEATYAERAQVILERCIHPADIPASKLREIIGTAYGENFTCSKIAPVRHLTGNQFLLELFHGPTASFKDFALQMMPHIFAYCIPRSCNYLVLVATSGDTGSAVLDGFSRLHGADKQRIAVLSFFPEDGVSPIQKSQMIGCQKENAWSVGVKSDFDFCQTAMKKIFTNSDYTGYLTVEYGTALAAANSINWARLLPQIVYHASAYLDLVHQGIIAFGDPVDVCIPTGNFGNILAALYAKMMGIPIRKCICASNENNVLTDFIRTGIYDLRGRKLVPTFSPAIDILKSSNLERYLHLIADGDGQLVTQLYDQLENQGHFQLRKDLLEKLQQDLVAGWCSEEDCLAAIHSVYSTTGYILDTHTAVAKVVADRLQDRTCPIIISSTAHYSKFAPAILRALRITEIKQNPLSQLHLLSSYSPLPPVHWGLLETLKKNENEGHRVCAADLNMLMSCIETLIQKHFMKVF", "length": 734 }, "evidence": [ { "id": "A0AAA9T2U9", "url": "https://omabrowser.org/oma/group/A0AAA9T2U9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9PTK4-1", "protein_name": "Threonine synthase-like 1", "gene_name": "Thnsl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSFTRCHHLKRITQKCFSSALVKVQTPTQLSLPRALACAESGKSWHSTHSLVGDKNIVLMGPPGAGKTTVGRILGDKLGCCVIDVDADVLEKTWNMSVSEKLQDVGNERFLEEEGKAVLNLFASGSVISLSGSNPMHDASMWHLKKNGIVVYLDVPLTDIISRLKSMRVDRIVGRNTGTSLRDLLKHGKLHYRKWYDARVFCESGASAEEVADKVLDVVKRYQDVDSETFISTRHVCLKDHDKKFPPKYFSEAVVEGLASDGGLFVPEKGFPKLSLGEWTNLIGATYIERAQVLLERCIHPADIPAAKLGEMIETAYGESFACSKVAPVRHLSGNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVLLVATSGDTGSAVLNGFSRLNRSDKERIAVLTFFPENGVSDFQRAEIVGSQRENGWAIGVKSDFDFCQAAIRKIFNDSDFTGFLTVEYGVVLSSANSINWARLLPQVVYHASAYLELVSQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRRLAQTFSPSINILKSSNLERHLYLMANKDGQLMADLYNQLESQLHFQIEELLVEKLQQDFVADWCSEGECLEAISTTYNTSGYILDPHTAVAKVVADKMQDKSCPVVIASTAHYSKFAPVVLQALRIKELNQTSASQLYLLSSYNALPPPHEALLERMKQKGKMDYQACVADVDVLKSHVEKLIQSWFREV", "length": 745 }, "evidence": [ { "id": "A0AAA9T2U9", "url": "https://omabrowser.org/oma/group/A0AAA9T2U9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3ICY2-1", "protein_name": "Threonine synthase-like 1", "gene_name": "Thnsl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLNFTRCQHLKQITQKCFSSAPVKVQTCTQLLLSRTFARSELGKSWHSTHSLVGDKNIILMGPPGAGKTTVGRIIGHKLGCCVIDVDDDILEKTWNMSASEKLQDVGNEQFLEEEGKAILNLSASGSVISLSGSNPMHDASMWHLKKNGIVVYLDVPLVDIISRLKSMKIDRIVGQNSGTPMRDLLKHRRLCYKKWYDARVFCESGASPEEVADKVLDVVKRYQDVDSETFISTRYFCPKDHDKRFPPKYFTEAVIEGLASDGGLFVPEKEFPKLSCGEWKSLIGANYVERAQILLERCIHPADIPATKLGEMIETAYGDNFACSKIAPVRHLSGNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVILVATSGDTGSAVLNGFSHLNKNDKQRIAVVTFFPENGVSDFQKAQIVSSQRENGWAIGVKSDFDFCQTTIKKIFNDSDFTGFLAVEYGTILSSANSINWARLLPQVVYHASAYLDLVGQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRKLAQTFSPSIDILKSSNLERHLYLMANKDGQLMSNLFNQLESQLHFQIEKILVEKLQQDFVADWCSEGECLEAISTTYNTSGYILDPHTAVAKVVADRMQDKTCPVIISSTAHYSKFAPAVMQALKIKELNQTSSSQLYLLGSYNALPPPHEALLERMKQQGKMDYQVCAADVSVLKGHVEKLIQNWFIKKSE", "length": 747 }, "evidence": [ { "id": "A0AAA9T2U9", "url": "https://omabrowser.org/oma/group/A0AAA9T2U9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8BH55-1", "protein_name": "Threonine synthase-like 1", "gene_name": "Thnsl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLTLTRCHHLKQIAQECLSSLLVKVQSRTQLLLPRASARAESGKSWHSTHSLVGDKNIVLMGPPGSGKTTVGRILGDKLGCCVIDVDSDVLEKAWNMSASEKLQDVGNERFLEEEGKTVLNLSASGSVISLSGSNPMHDASMWHLKKNGIVVYLDVPLTDIISRLKSMRIDRIVGQNTGASLRDSLKHVRLYYKKWYDARVFCESGASAEEVADKVLDVVKRYQDVDSETFISTRHVCLKDHDKKFPPKYFSEAVVEGLASDGGLFVPEKEFPKLSPGEWNNLIGATYIERAQVLLERCIHPADIPAAKLGEMIETAYGENFACSKVAPVRHLSGNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVILVATSGDTGSAVLNGFSHLNKNDKERIAVVTFFPENGVSDFQKAEIIGSQRENGWAIGVRSDFDFCQTAIRKIFNDSDFTGFLAVEYGTILSSANSINWARLLPQIVYHASAYLELVNQRFISFGSPVDVCVPTGNFGNVLAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRKLAQTFSPSIDILKSSNLERHLYLMANKDGQLMANLYHQLESQLHFRIEKMLVEKLQQEFVADWCSEGECLAAISTTYNASGYILDPHTAVAKVVADKMQDKSCPVLIASTAHYSKFAPAIMQALGIKELNQTSSSQLYLLSSYNALPPPHEALLERMKQKEKMDYQVCVADVDVLKSHAEKLIQNWFVRKSE", "length": 747 }, "evidence": [ { "id": "A0AAA9T2U9", "url": "https://omabrowser.org/oma/group/A0AAA9T2U9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYQ7-1", "protein_name": "Threonine synthase-like 1", "gene_name": "THNSL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLHFNRCHHLKKITQKCFSSIHVKTDKHAQRFLSRTFALAELRKSWYSTHSLVGDKNIILMGPPGAGKTTVGRIIGQKLGCCVIDVDDDILEKTWNMSVSEKLQDVGNEQFLEEEGKAVLNFSASGSVISLTGSNPMHDASMWHLKKNGIIVYLDVPLLDLICRLKLMKTDRIVGQNSGTSMKDLLKFRRQYYKKWYDARVFCESGASPEEVADKVLNAIKRYQDVDSETFISTRHVWPEDCEQKVSAKFFSEAVIEGLASDGGLFVPAKEFPKLSCGEWKSLVGATYVERAQILLERCIHPADIPAARLGEMIETAYGENFACSKIAPVRHLSGNQFILELFHGPTGSFKDLSLQLMPHIFAHCIPPSCNYMILVATSGDTGSAVLNGFSRLNKNDKQRIAVVAFFPENGVSDFQKAQIIGSQRENGWAVGVESDFDFCQTAIKRIFNDSDFTGFLTVEYGTILSSANSINWGRLLPQVVYHASAYLDLVSQGFISFGSPVDVCIPTGNFGNILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRERKLAQTFSPSIDILKSSNLERHLHLMANKDGQLMTELFNRLESQHHFQIEKALVEKLQQDFVADWCSEGECLAAINSTYNTSGYILDPHTAVAKVVADRVQDKTCPVIISSTAHYSKFAPAIMQALKIKEINETSSSQLYLLGSYNALPPLHEALLERTKQQEKMEYQVCAADMNVLKSHVEQLVQNQFI", "length": 743 }, "evidence": [ { "id": "A0AAA9T2U9", "url": "https://omabrowser.org/oma/group/A0AAA9T2U9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 685, "end_pos": 687, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2U9" }, { "id": "PF14821", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14821" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Threonine synthase N-terminal", "eco_id": "ECO_0000259", "start_pos": 247, "end_pos": 318, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 121, "end_pos": 123 }, { "start_pos": 321, "end_pos": 323 }, { "start_pos": 633, "end_pos": 635 }, { "start_pos": 685, "end_pos": 687 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"MGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQGEEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK", "length": 180, "header": "tr|A0AAA9T325-1|A0AAA9T325_BOVIN Isoform 1 of PDGFA associated protein 1 OS=Bos taurus OX=9913 GN=PDAP1 PE=4 SV=1 CANONICAL=A0AAA9T325-1" }, "locus": { "chromosome": "25", "start_pos": 37003143, "end_pos": 36990476, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108151.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108151.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092149.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092149.1" } ] } }, { "isoform_ac": "A0AAA9TKV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T325/entry#A0AAA9TKV8-1", "sequence": { "sequence": "MERGDCVTLGVRSPACVEFQRRCLLSSALPGGVGWQAPAPPAAGVGRGSVAQQRAASLGSGGAWARPASLRAAVLAAARRAEKGPGGGAGGRETGLAEEVEPEEFPVPVSARGAAAAAAGAAMPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQGEEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK", "length": 304, "header": "tr|A0AAA9TKV8-1|A0AAA9TKV8_BOVIN Computationally mapped isoform of PDGFA associated protein 1 OS=Bos taurus OX=9913 GN=PDAP1 PE=4 SV=1 CANONICAL=A0AAA9T325-1" }, "locus": { "chromosome": "25", "start_pos": 37003143, "end_pos": 36991040, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131228.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131228.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097821.1" } ] } }, { "isoform_ac": "A0ABI0NSE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T325/entry#A0ABI0NSE9-1", "sequence": { "sequence": "MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKARIAHF", "length": 39, "header": "tr|A0ABI0NSE9-1|A0ABI0NSE9_BOVIN Computationally mapped isoform of PDGFA associated protein 1 OS=Bos taurus OX=9913 GN=PDAP1 PE=4 SV=1 CANONICAL=A0AAA9T325-1" }, "locus": { "chromosome": "25", "start_pos": 36996133, "end_pos": 36991406, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146400.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146400.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105819.1" } ] } }, { "isoform_ac": "F1MNS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T325/entry#F1MNS8-1", "sequence": { "sequence": "MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQGEEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKDGGGRSCLPPPRILEGSSSRRIESQQSNVHSI", "length": 195, "header": "tr|F1MNS8-1|A0AAA9T325_BOVIN Computationally mapped isoform of PDGFA associated protein 1 OS=Bos taurus OX=9913 GN=PDAP1 PE=4 SV=4 CANONICAL=A0AAA9T325-1" }, "locus": { "chromosome": "25", "start_pos": 37000674, "end_pos": 36991406, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061310.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061310.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053400.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053400.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T325", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T325" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T325" }, { "id": "PF10252", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10252" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Casein kinase substrate phosphoprotein PP28", "eco_id": "ECO_0000259", "start_pos": 84, "end_pos": 161, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T330-1", "uniprot_ac": "A0AAA9T330", "uniprot_id": "A0AAA9T330_BOVIN", "mass": { "chemical_mass": 32326.0, "monoisotopic_mass": 32326.0 }, "refseq": { "ac": "XP_005214993", "name": "protein phosphatase 1 regulatory subunit 3D", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214993" }, "gene_names": [ { "name": "PPP1R3D", "type": "recommended", "evidence": [ { "id": "A0AAA9T330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330" } ] }, { "name": "PPP1R3D", "type": "synonym", "evidence": [ { "id": "XP_005214993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214993" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit", "type": "recommended", "evidence": [ { "id": "A0AAA9T330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase 1 regulatory subunit 3D", "type": "synonym", "evidence": [ { "id": "XP_005214993", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214993" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T330", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R3D", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330", "locus": { "chromosome": "13", "start_pos": 56612008, "end_pos": 56592889, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000061854", "url": "https://www.ensembl.org/id/ENSBTAG00000061854" } ] } } ], "crossref": [ { "id": "782160", "url": "https://www.ncbi.nlm.nih.gov/gene/782160", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050782", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050782", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782160", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782160", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLEQVVC", "url": "https://omabrowser.org/oma/group/CLEQVVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12307:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12307:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214993", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T330", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T330-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGGPGSAVLPATVGFRKPAPRSLSCLSDLDGGAAREPRPCRPPGSPGSAPPPPPAPSGCDPHLRPIILRRARSLPSSPERRQKGAGAPGAACRPGCSRQHRVRFADALGLELAQVKVFNAGEDPSVPLHVLSRLAINSDLCCSSQDLEFTLQCLVPDFPPPVEAPDFGERLGRQLVCLERVTCSDLGISGTVRVRNVAFEKQVAVRYTFSDWRSAHEVAARWRGPAGSGGSEDVFAFGFPVPPFLLELGSRVHFALRYRVAGAEHWDNNDGRDYSLTCRNHALHMPRGECEESWIHFI", "length": 299, "header": "tr|A0AAA9T330-1|A0AAA9T330_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit OS=Bos taurus OX=9913 GN=PPP1R3D PE=4 SV=1 CANONICAL=A0AAA9T330-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T330-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T330/entry#A0AAA9T330-1", "sequence": { "sequence": "MSGGPGSAVLPATVGFRKPAPRSLSCLSDLDGGAAREPRPCRPPGSPGSAPPPPPAPSGCDPHLRPIILRRARSLPSSPERRQKGAGAPGAACRPGCSRQHRVRFADALGLELAQVKVFNAGEDPSVPLHVLSRLAINSDLCCSSQDLEFTLQCLVPDFPPPVEAPDFGERLGRQLVCLERVTCSDLGISGTVRVRNVAFEKQVAVRYTFSDWRSAHEVAARWRGPAGSGGSEDVFAFGFPVPPFLLELGSRVHFALRYRVAGAEHWDNNDGRDYSLTCRNHALHMPRGECEESWIHFI", "length": 299, "header": "tr|A0AAA9T330-1|A0AAA9T330_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit OS=Bos taurus OX=9913 GN=PPP1R3D PE=4 SV=1 CANONICAL=A0AAA9T330-1" }, "locus": { "chromosome": "13", "start_pos": 56609270, "end_pos": 56608374, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105310.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105310.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076709.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076709.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782160", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782160", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RJ12-1", "protein_name": "Protein phosphatase 1 regulatory subunit", "gene_name": "PPP1R3D", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGDPGSAVPPAAPAFRKPAPRSLSCLSDLYGGAAPEPRPCRPPGSPGRAPPPPTPPSGCDPRLRPIILRRARSLPSSPERRQKGAGAPGAACRPGCSRQHRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLQCLVPDFPPPVEAPDFGERLGRQLVCLERVTCSDLGISGTVRVRNVAFEKQVAVRYTFSDWQSAHEAGARWRGPAGAEGAEDVFAFGFPVPPFLLALGSRVHFALRYRVAGAEYWDNNDGRDYSLTCRNHALHMPRGECEESWIHFI", "length": 299 }, "evidence": [ { "id": "A0AAA9T330", "url": "https://omabrowser.org/oma/group/A0AAA9T330/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95685-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3D", "gene_name": "PPP1R3D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRGPSSAVLPSALGSRKLGPRSLSCLSDLDGGVALEPRACRPPGSPGRAPPPTPAPSGCDPRLRPIILRRARSLPSSPERRQKAAGAPGAACRPGCSQKLRVRFADALGLELAQVKVFNAGDDPSVPLHVLSRLAINSDLCCSSQDLEFTLHCLVPDFPPPVEAADFGERLQRQLVCLERVTCSDLGISGTVRVCNVAFEKQVAVRYTFSGWRSTHEAVARWRGPAGPEGTEDVFTFGFPVPPFLLELGSRVHFAVRYQVAGAEYWDNNDHRDYSLTCRNHALHMPRGECEESWIHFI", "length": 299 }, "evidence": [ { "id": "A0AAA9T330", "url": "https://omabrowser.org/oma/group/A0AAA9T330/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WFN1-1", "protein_name": "Protein phosphatase 1, regulatory subunit 3Db", "gene_name": "ppp1r3db", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESHPYVSGPALQLTSAFGELSKPNKTFHLRNIYNPKPPPQRPPVAIRPPSPKAGSVPPPQDAVIRRRLSCEPEPKPIMRRRAKSLSSSSDRQTCRNIQVRFVDSLGLQLEDVKFFKSSEDPLVPVHVITRLLASSELASKKNLELSLPYFQPSFPDNMTTDVSAFSRRLCRQRVCLEQVFCSELGITGTAQVLNLCFQKEVIVRYSFTDWRSSADCRAGWVCSVRRGDLESDVFRFLLPVPPFIMQPGAVLQFAICFRVPGSEFWDNNDGCNYKLTCQTYKLTVPRECEDSLVHFI", "length": 297 }, "evidence": [ { "id": "A0AAA9T330", "url": "https://omabrowser.org/oma/group/A0AAA9T330/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycogen metabolic process", "id": 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domain-containing protein 17 OS=Bos taurus OX=9913 GN=TXNDC17 PE=1 SV=1 CANONICAL=A0AAA9T355-1" }, "locus": { "chromosome": "19", "start_pos": 25238233, "end_pos": 25236278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093946.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093946.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:404159", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404159", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZZM7-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "TXNDC17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARYEEVSVSGYEEFIQAVKQHNGKTIFAYFSGSKDAEGKSWCPDCVQAEPVVREGLKHTVEGCVFIYCQVGERLYWKDPNNDFRKKLKLTAVPTLLKYGTPQKLVESECLQTNLVEMLFSEE", "length": 123 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7GM56-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "Txndc17", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATCKEVNVSGFEEFDQAVKEHKGKTIFAYFSGSKDAEGKSWCPDCVEAEPVVREGLKSVTEDCVFIYCQVGDKSYWKDPNNDFRQQLQVTAVPTLLKYGTPQKLVESECSQANLVEMIFSED", "length": 123 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0G106-1", "protein_name": "Thioredoxin fold domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGLVNKIVVTNADGFDKTLQDSLKSNETVFVQFISSIDKTTCSLWCRDCQVSEPIVNSVFENLPKNITYIECQIEREGGNPNHPYRTNPTLKLTAIPTLIVLLTKDGPKPKTLVEEDLAKEENVKQFVNEYL", "length": 132 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6DBT3-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "txndc17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKYEEVAVHGYEEFCKAVSDRKGKEIFAYFSGDKDEHGKSWCPDCVKAEPVVRAELPHLPEGTVFIYCQVGDRPYWKDSNNDFKKTLKLTGVPTLLRYGTPQKLVEEECFKADLVRMMFTED", "length": 123 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BRA2-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "TXNDC17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED", "length": 123 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CQM5-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "Txndc17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATFEEVSVLGFEEFDKAVKEHEGKTIFAYFSGSKDTEGKSWCPDCVEAEPVIREGLKHVTEDCVFIYCQVGDKPYWKDPNNDFRQKLKITAVPTLLKYGTPQKLVESECCQSSLVEMIFSED", "length": 123 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VMQ9-1", "protein_name": "Thioredoxin domain-containing protein 17", "gene_name": "cl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVVTHNVKGYDEFTKKMEELENGDEPVHVLFSGGKDEKGESWCPYCVKAEPVIHDALKKAPGNSHFVHVDVGERAYWKDLNCPFRKDPNTHLIFLPTLLRWKRPQRLDGERCSNQDLVEMMFEDED", "length": 126 }, "evidence": [ { "id": "A0AAA9T355", "url": "https://omabrowser.org/oma/group/A0AAA9T355/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T355", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T355" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tumor necrosis factor-mediated signaling pathway", "id": "GO:0033209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T355", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T355" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peroxidase activity", "id": "GO:0004601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T355", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T355" } ], "pmid": "" }, { "name": "protein-disulfide reductase [NAD(P)H] activity", "id": "GO:0047134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047134", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T355", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T355" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T355" }, { "id": "PF06110", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06110" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 122, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T391-1", "uniprot_ac": "A0AAA9T391", "uniprot_id": "A0AAA9T391_BOVIN", "mass": { "chemical_mass": 54204.0, "monoisotopic_mass": 54204.0 }, "refseq": {}, "gene_names": [ { "name": "TMCO6", "type": "recommended", "evidence": [ { "id": "A0AAA9T391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391" } ] } ], "protein_names": [ { "name": "Transmembrane and coiled-coil domains 6", "type": "synonym", "evidence": [ { "id": "A0AAA9T391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T391", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMCO6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391", "locus": { "chromosome": "7", "start_pos": 51778631, "end_pos": 51765289, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030589", "url": "https://www.ensembl.org/id/ENSBTAG00000030589" } ] } } ], "crossref": [ { "id": "A0AAA9T391", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T391", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030589", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030589", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N358", "url": "https://www.orthodb.org/?gene=F1N358", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16356", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16356", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16356:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16356:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9T391", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T391-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N358", "url": "https://www.uniprot.org/uniprotkb/F1N358", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N358-1", "url": "https://www.uniprot.org/uniprotkb/F1N358-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SCRHNGNRRRPARRVLLCPQTHAAVTAAAAAAALRKARREQQLVSKRLLRDEATEEAEGGCVVVILGEAEIQEFLRLAQRGTEEKERERALVSLRRGLQHPETQQTFIRLEGSIRTLVGLLTSNQALLQLEAARCLHELSHSEQSAVAEACLPATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHLTVLEALGYALSQLLQAKEAPEKIIPLVLGSTLPQHILQLLQPGPKLNLGVAVEFAWCLHYIICSQVNNALLITQGALTTLGLLLLDLAAAVQRTEDAGLELLVCPVVRCLSNLLTEAAAETVGGPMQLRDERVLAALFILLQFFLHKQPSLLPEGLWLLNNLTANSPSFCTSLISLDLIEPLLHLLSVSNVVSVLVLTVLCNIAEKGPAYCQHLWPGLLLPTLLDTLALSDTEVVGQSLELLQLLFLYQPGAAQAFLQQSGLQALQRHEEVAQLQDRVHALQQTALHG", "length": 497, "header": "tr|A0AAA9T391-1|A0AAA9T391_BOVIN Isoform 1 of Transmembrane and coiled-coil domains 6 OS=Bos taurus OX=9913 GN=TMCO6 PE=4 SV=1 CANONICAL=A0AAA9T391-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T391-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391/entry#A0AAA9T391-1", "sequence": { "sequence": "SCRHNGNRRRPARRVLLCPQTHAAVTAAAAAAALRKARREQQLVSKRLLRDEATEEAEGGCVVVILGEAEIQEFLRLAQRGTEEKERERALVSLRRGLQHPETQQTFIRLEGSIRTLVGLLTSNQALLQLEAARCLHELSHSEQSAVAEACLPATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHLTVLEALGYALSQLLQAKEAPEKIIPLVLGSTLPQHILQLLQPGPKLNLGVAVEFAWCLHYIICSQVNNALLITQGALTTLGLLLLDLAAAVQRTEDAGLELLVCPVVRCLSNLLTEAAAETVGGPMQLRDERVLAALFILLQFFLHKQPSLLPEGLWLLNNLTANSPSFCTSLISLDLIEPLLHLLSVSNVVSVLVLTVLCNIAEKGPAYCQHLWPGLLLPTLLDTLALSDTEVVGQSLELLQLLFLYQPGAAQAFLQQSGLQALQRHEEVAQLQDRVHALQQTALHG", "length": 497, "header": "tr|A0AAA9T391-1|A0AAA9T391_BOVIN Isoform 1 of Transmembrane and coiled-coil domains 6 OS=Bos taurus OX=9913 GN=TMCO6 PE=4 SV=1 CANONICAL=A0AAA9T391-1" }, "locus": { "chromosome": "7", "start_pos": 51778134, "end_pos": 51765488, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105912.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105912.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092227.1" } ] } }, { "isoform_ac": "A0AAA9TJR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391/entry#A0AAA9TJR5-1", "sequence": { "sequence": "SCWLSSSCRIFPLLSCGADGGASSGRQAAEWRSYALRKARREQQLVSKRLLRDEATEEAEGGCVVVILGEAEIQEFLRLAQRGTEEKERERALVSLRRGLQHPETQQTFIRLEGSIRTLVGLLTSNQALLQLEAARCLHELSHSEQSAVAEACLPATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQSPHLTVLEALGYALSQLLQAKEAPEKIIPLVLGSTLPQHILQLLQPGPKLNLGVAVEFAWCLHYIICSQVNNALLITQGALTTLGLLLLDLAAAVQRTEDAGLELLVCPVVRCLSNLLTEAAAETVGGPMQLRDERVLAALFILLQFFLHKQPSLLPEGLWLLNNLTANSPSFCTSLISLDLIEPLLHLLSVSNVVSVLVLTVLCNIAEKGPAYCQHLWPGLLLPTLLDTLALSDTEVVGQSLELLQLLFLYQPGAAQAFLQQSGLQALQRHEEVAQLQDRVHALQQTALHG", "length": 499, "header": "tr|A0AAA9TJR5-1|A0AAA9TJR5_BOVIN Computationally mapped isoform of Transmembrane and coiled-coil domains 6 OS=Bos taurus OX=9913 GN=TMCO6 PE=4 SV=1 CANONICAL=A0AAA9T391-1" }, "locus": { "chromosome": "7", "start_pos": 51778134, "end_pos": 51772678, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091695.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091695.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098600.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098600.1" } ] } }, { "isoform_ac": "F1N358-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T391/entry#F1N358-1", "sequence": { "sequence": "MWSGRRGLLRSSGCGVEELRCRRREREAALRKARREQQLVSKRLLRDEATEEAEGGCVVVILGEAEIQEFLRLAQRGTEEKERERALVSLRRGLQHPETQQTFIRLEGSIRTLVGLLTSNQALLQLEAARCLHELSHSEQSAVAEACLPATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAACIQLGPGLYSPPAHTATVTAWPKAEPWGSCGVCLVPSLHHLQVNNALLITQGALTTLGLLLLDLAAAVQRTEDAGLELLVCPVVRCLSNLLTEAAAETVGGPMQLRDERVLAALFILLQFFLHKQPSLLPEGLWLLNNLTANSPSFCTSLISLDLIEPLLHLLSVSNVVSVLVLTVLCNIAEKGPAYCQHLWPGLLLPTLLDTLALSDTEVVGQSLELLQLLFLYQPGAAQAFLQQSGLQALQRHEEVAQLQDRVHALQQTALHG", "length": 463, "header": "tr|F1N358-1|F1N358_BOVIN Computationally mapped isoform of Transmembrane and coiled-coil domains 6 OS=Bos taurus OX=9913 GN=TMCO6 PE=4 SV=3 CANONICAL=A0AAA9T391-1" }, "locus": { "chromosome": "7", "start_pos": 51778134, "end_pos": 51772722, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043202.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043202.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040790.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040790.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 26, "start_aa": "Thr", "end_pos": 26, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr26", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", 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"MAPLGYFIFLYGLKQALGNYPIWWSLAVGPQYSSLGTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKISIQECQHQFRGRRWNCTTINNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRHQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTEQRREKCHCVFHWCCYERSKASCSRLAVAALMASAPLSSTLIHSPL", "length": 366, "header": "tr|F1MDZ7-1|F1MDZ7_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT3A PE=3 SV=3 CANONICAL=A0AAA9T3A6-1" }, "locus": { "chromosome": "7", "start_pos": 3107320, "end_pos": 3036581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056888.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056888.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048402.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048402.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": 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activity" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 28, "go_terms": [ { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "cardiac muscle cell fate commitment", "id": "GO:0060923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "positive regulation of receptor internalization", "id": "GO:0002092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002092", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "negative regulation of neurogenesis", "id": "GO:0050768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "cell proliferation in forebrain", "id": "GO:0021846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021846", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3A6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3A6" } ], "pmid": "" }, { "name": "COP9 signalosome assembly", "id": "GO:0010387", "url": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377104" }, "gene_names": [ { "name": "OR10H4I", "type": "recommended", "evidence": [ { "id": "A0AAA9T3X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X3" } ] }, { "name": "OR10H4I", "type": "synonym", "evidence": [ { "id": "NP_001377104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377104" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 10 subfamily H member 4I", "type": "synonym", "evidence": [ { "id": "A0AAA9T3X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10H3", "type": "synonym", "evidence": [ { "id": "NP_001377104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377104" } ] }, { "name": "olfactory receptor family 10 subfamily H member 4I", "type": "synonym", "evidence": [ { "id": "NP_001377104", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377104" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X3#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"MYLFTLLGNLLIMGTIWREHSLHTPMYLFLCALSISEILFTVTITPEMLVDMLSTHHSITFVACASQMFFSFMFGYTHSFLLMIMGYDRYVAICHPLHYNVLMSTRDCARLVSWCWAGGSVMGMMVTLIVFLLTFCGSNEIHHFFCHIFSLLKLACGRDTASLTLAVILVCVTALIGCLFLIVLSYVFIVAAILRIPSTEGRHKTFSTCVSHLTIVVVHYGFASIIYLKPKGPRSMDSNILMTTTYTVFTPFLSPIIFSLRNKELKNAIKRSFRRTFCPLNS", "length": 282, "header": "tr|A0AAA9T3X3-1|A0AAA9T3X3_BOVIN Isoform 1 of Olfactory receptor family 10 subfamily H member 4I OS=Bos taurus OX=9913 GN=OR10H4I PE=3 SV=1 CANONICAL=A0AAA9T3X3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3X3/entry#A0AAA9T3X3-1", "sequence": { "sequence": "MYLFTLLGNLLIMGTIWREHSLHTPMYLFLCALSISEILFTVTITPEMLVDMLSTHHSITFVACASQMFFSFMFGYTHSFLLMIMGYDRYVAICHPLHYNVLMSTRDCARLVSWCWAGGSVMGMMVTLIVFLLTFCGSNEIHHFFCHIFSLLKLACGRDTASLTLAVILVCVTALIGCLFLIVLSYVFIVAAILRIPSTEGRHKTFSTCVSHLTIVVVHYGFASIIYLKPKGPRSMDSNILMTTTYTVFTPFLSPIIFSLRNKELKNAIKRSFRRTFCPLNS", "length": 282, "header": "tr|A0AAA9T3X3-1|A0AAA9T3X3_BOVIN Isoform 1 of Olfactory 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"XP_024841410", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841410", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T421-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSCYDPGLDGIIEYDDFKFNPSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGGSLGFFPSSLAYSPYQSGAAPMGCYPGGGGGAQMAAETPSVDAGEEAAEPSAPPGTPQREQQTPELLHRAREYNARLFGLAQRSARALLDYGVTADARSLLAGQRHLLTAQDENGDTPLHLAIIHGQTTVIEQIAHVIYHAPHLGVVNITNHLHQTPLHLAVITGQTKVVSFLLQVGADPALLDRHGDSAVHLALRAGASAPDMLCALLRSGVPAMPQLLHVPDFEGLYPVHLAVRARSPECLDLLVESGAEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADVHAENEEPLCPLPSPPTSGSDSDSESPERDTRGSFRGHTPLDLTRSSKVKTLLLNAAQDTMAPPLTPPSPAGPEIPLEDTVLQNLEHLLDGPGAQGSWVELAERLGLRSLVDTYRRTASPSGSLLRSYQLAGGDWTGLLNALSDMGLEEGVRLLKGPETQEKLPSTAEVKEDSAYGSQSVEQETEKLGPPPEPPGGLCHGRPQPQVH", "length": 901, "header": "tr|A0AAA9T421-1|A0AAA9T421_BOVIN Isoform 1 of Nuclear factor NF-kappa-B p100 subunit OS=Bos taurus OX=9913 GN=NFKB2 PE=4 SV=1 CANONICAL=A0AAA9T421-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T421-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421/entry#A0AAA9T421-1", "sequence": { "sequence": "MDSCYDPGLDGIIEYDDFKFNPSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGGSLGFFPSSLAYSPYQSGAAPMGCYPGGGGGAQMAAETPSVDAGEEAAEPSAPPGTPQREQQTPELLHRAREYNARLFGLAQRSARALLDYGVTADARSLLAGQRHLLTAQDENGDTPLHLAIIHGQTTVIEQIAHVIYHAPHLGVVNITNHLHQTPLHLAVITGQTKVVSFLLQVGADPALLDRHGDSAVHLALRAGASAPDMLCALLRSGVPAMPQLLHVPDFEGLYPVHLAVRARSPECLDLLVESGAEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADVHAENEEPLCPLPSPPTSGSDSDSESPERDTRGSFRGHTPLDLTRSSKVKTLLLNAAQDTMAPPLTPPSPAGPEIPLEDTVLQNLEHLLDGPGAQGSWVELAERLGLRSLVDTYRRTASPSGSLLRSYQLAGGDWTGLLNALSDMGLEEGVRLLKGPETQEKLPSTAEVKEDSAYGSQSVEQETEKLGPPPEPPGGLCHGRPQPQVH", "length": 901, "header": "tr|A0AAA9T421-1|A0AAA9T421_BOVIN Isoform 1 of Nuclear factor NF-kappa-B p100 subunit OS=Bos taurus OX=9913 GN=NFKB2 PE=4 SV=1 CANONICAL=A0AAA9T421-1" }, "locus": { "chromosome": "26", "start_pos": 23025934, "end_pos": 23019830, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135447.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135447.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091405.1" } ] } }, { "isoform_ac": "A0AAF6DLJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421/entry#A0AAF6DLJ2-1", "sequence": { "sequence": "MDSCYDPGLDGIIEYDDFKFNPSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSRPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEGGSLGFFPSSLAYSPYQSGAAPMGCYPGGGGGAQMAAETPSVDAGEEAAEPSAPPGTPQREQQTPELLHRAREYNARLFGLAQRSARALLDYGVTADARSLLAGQRHLLTAQDENGDTPLHLAIIHGQTTVIEQIAHVIYHAPHLGVVNITNHLHQTPLHLAVITGQTKVVSFLLQVGADPALLDRHGDSAVHLALRAGASAPDMLCALLRSGVPAMPQLLHVPDFEGLYPVHLAVRARSPECLDLLVESGAEVEAAERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADVHAENEEPLCPLPSPPTSGSDSDSESPERDTRGSFRGHTPLDLTRSSKVKTLLLNAAQDTMAPPLTPPSPAGPEIPLEDTVLQNLEHLLDGPGAQGSWVELAERLGLRSLVDTYRRTASPSGSLLRSYQLAGGDWTGLLNALSDMGLEEGVRLLKGPETQEKLPSTEVKEDSAYGSQSVEQETEKLGPPPEPPGGLCHGRPQPQVH", "length": 857, "header": "tr|A0AAF6DLJ2-1|A0AAF6DLJ2_BOVIN Computationally mapped isoform of Nuclear factor NF-kappa-B p100 subunit OS=Bos taurus OX=9913 GN=NFKB2 PE=4 SV=1 CANONICAL=A0AAA9T421-1" }, "locus": { "chromosome": "26", "start_pos": 23025934, "end_pos": 23019830, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007904.8", "url": "https://www.ensembl.org/id/ENSBTAT00000007904.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007904.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007904.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "Bcl3/NF-kappaB2 complex", "id": "GO:0033257", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033257", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "canonical NF-kappaB signal transduction", "id": "GO:0007249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "non-canonical NF-kappaB signal transduction", "id": "GO:0038061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "intracellular signaling cassette", "id": "GO:0141124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T421", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T421" }, { "id": "PS50254", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50254" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RHD", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 224, "start_aa": "Ala", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 522, "end_pos": 524 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T429-1", "uniprot_ac": "A0AAA9T429", "uniprot_id": "A0AAA9T429_BOVIN", "mass": { "chemical_mass": 14746.0, "monoisotopic_mass": 14746.0 }, "refseq": { "ac": "XP_002688796", "name": "relaxin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688796" }, "gene_names": [ { "name": "RLN3", "type": "recommended", "evidence": [ { "id": "A0AAA9T429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429" } ] }, { "name": "RLN3", "type": "synonym", "evidence": [ { "id": "XP_002688796", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688796" } ] } ], "protein_names": [ { "name": "Relaxin-3", "type": "recommended", "evidence": [ { "id": "A0AAA9T429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429/entry#names_and_taxonomy" } ] }, { "name": "relaxin-3", "type": "synonym", "evidence": [ { "id": "XP_002688796", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688796" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T429", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RLN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429", "locus": { "chromosome": "7", "start_pos": 11665211, "end_pos": 11667810, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055930", "url": "https://www.ensembl.org/id/ENSBTAG00000055930" } ] } } ], "crossref": [ { "id": "A0AAA9T429", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T429", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd04365", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04365", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100300034", "url": "https://www.ncbi.nlm.nih.gov/gene/100300034", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300034", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300034", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGCSKRE", "url": "https://omabrowser.org/oma/group/WGCSKRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR20968", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20968", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20968:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20968:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688796", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688796", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T429", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T429-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRHLVLLLLALGVLTGELLPRTEARATAYGVKLCGREFIRAVIFTCGGSRWRRAHDAVEDTFPEVDTDSESELDEAVASSEWLALTKSPQAFYGGRQDWQGTPGSLRGRRDVLAGLSSSCCKRGCSKSEIGRLC", "length": 135, "header": "tr|A0AAA9T429-1|A0AAA9T429_BOVIN Isoform 1 of Relaxin-3 OS=Bos taurus OX=9913 GN=RLN3 PE=3 SV=1 CANONICAL=A0AAA9T429-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T429-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T429/entry#A0AAA9T429-1", "sequence": { "sequence": "MVRHLVLLLLALGVLTGELLPRTEARATAYGVKLCGREFIRAVIFTCGGSRWRRAHDAVEDTFPEVDTDSESELDEAVASSEWLALTKSPQAFYGGRQDWQGTPGSLRGRRDVLAGLSSSCCKRGCSKSEIGRLC", "length": 135, "header": "tr|A0AAA9T429-1|A0AAA9T429_BOVIN Isoform 1 of Relaxin-3 OS=Bos taurus OX=9913 GN=RLN3 PE=3 SV=1 CANONICAL=A0AAA9T429-1" }, "locus": { "chromosome": "7", "start_pos": 11667611, "end_pos": 11665839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090451.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100300034", "name": "", "url": 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}, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T436-1", "uniprot_ac": "A0AAA9T436", "uniprot_id": "A0AAA9T436_BOVIN", "mass": { "chemical_mass": 24632.0, "monoisotopic_mass": 24632.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Ribonuclease A-domain domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T436", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436", "locus": {} } ], "crossref": [ { "id": "A0AAA9T436", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T436", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11437", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11437", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11437:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11437:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00074", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00074", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T436", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T436-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSQ0", "url": "https://www.uniprot.org/uniprotkb/F1MSQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSQ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MSQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVISQIFVSVLLESHPQKTSVLFSRSRSEGTAVRRYPSSKEPLLEKMVMGLSPLFLVFMLGLGLTPLTLAEDDHRYRHFLIQHYDRSPKGRDNKYCETMMEKRHLTKPCKSINTFVHGNKNDIKDICKDKNGKPYGGNLRISKSPFQVTICKHKGGSTRPPCHYKATKDYRVIVIGCEKGWPVHFMSPLSLHTSSPELVLLFLRSISPLHRGNIHC", "length": 216, "header": "tr|A0AAA9T436-1|A0AAA9T436_BOVIN Isoform 1 of Ribonuclease A-domain domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T436-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T436-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436/entry#A0AAA9T436-1", "sequence": { "sequence": "MVISQIFVSVLLESHPQKTSVLFSRSRSEGTAVRRYPSSKEPLLEKMVMGLSPLFLVFMLGLGLTPLTLAEDDHRYRHFLIQHYDRSPKGRDNKYCETMMEKRHLTKPCKSINTFVHGNKNDIKDICKDKNGKPYGGNLRISKSPFQVTICKHKGGSTRPPCHYKATKDYRVIVIGCEKGWPVHFMSPLSLHTSSPELVLLFLRSISPLHRGNIHC", "length": 216, "header": "tr|A0AAA9T436-1|A0AAA9T436_BOVIN Isoform 1 of Ribonuclease A-domain domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T436-1" }, "locus": { "chromosome": "10", "start_pos": 26319741, "end_pos": 26288850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128651.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128651.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091420.1" } ] } }, { "isoform_ac": "F1MSQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436/entry#F1MSQ0-1", "sequence": { "sequence": "MVMGLSPLFLVFMLGLGLTPLTLAEDDHRYRHFLIQHYDRSPKGRDNKYCETMMEKRHLTKPCKSINTFVHGNKNDIKDICKDKNGKPYGGNLRISKSPFQVTICKHKGGSTRPPCHYKATKDYRVIVIGCEKGWPVHFMSPLSLHTSSPELVLLFLRSISPLHRGNIHC", "length": 170, "header": "tr|F1MSQ0-1|F1MSQ0_BOVIN Computationally mapped isoform of Ribonuclease A-domain domain-containing protein OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=A0AAA9T436-1" }, "locus": { "chromosome": "10", "start_pos": 26289359, "end_pos": 26288850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046671.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046671.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043945.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043945.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T436", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T436", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T436", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T436" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T473-1", "uniprot_ac": "A0AAA9T473", "uniprot_id": "A0AAA9T473_BOVIN", "mass": { "chemical_mass": 138337.0, "monoisotopic_mass": 138337.0 }, "refseq": {}, "gene_names": [ { "name": "RPGRIP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ] } ], "protein_names": [ { "name": "X-linked retinitis pigmentosa GTPase regulator-interacting protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T473", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.", "evidence": [ { "database": "UniProtKB", "id": "F1MII7", "url": "https://www.uniprot.org/uniprotkb/F1MII7#function" }, { "database": "UniProtKB", "id": "ARBA00055830", "url": "https://www.uniprot.org/uniprotkb/ARBA00055830#function" }, { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPGRIP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473", "locus": { "chromosome": "10", "start_pos": 25807381, "end_pos": 25869090, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004694", "url": "https://www.ensembl.org/id/ENSBTAG00000004694" } ] } } ], "crossref": [ { "id": "A0AAA9T473", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T473", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004694", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004694", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031139", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031139", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041091", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041091", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MII7", "url": "https://www.orthodb.org/?gene=F1MII7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14240", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14240", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14240:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14240:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11618", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11618", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18111", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18111", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T473-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T836", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T836", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T836-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T836-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MII7", "url": "https://www.uniprot.org/uniprotkb/F1MII7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MII7-1", "url": "https://www.uniprot.org/uniprotkb/F1MII7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIPTSKGKNTKTQPPLSRMTRDELEDSLFRLREEHMLVKELFWKQQDEIKRMRTALLRLTASGQGLRAEAAAAESSGSPLNGGGTQSGGSAPSSTSVPRCPGSSCSSSAWAPLLPAAPSLASTRDTDSSTPPGHRAEKPKRESRDRLSYTAPPTFKEHVTNEKARGEVASEPSELGHLMTSDTMQVEEPPKSPEKMWSKDENFAQRSSLESTQKATELRASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAAYETLLHKNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEEQLKDVAYGTRQLPLCLKPLPAHENEDKVDISPWHQSENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLVVGPQPLYDFTSQYVVEIDSLFLHYLQGASAQLDLHQAIASEHHTLAAGWICFDRVLETVERVHGSATLTGTGGEVFGVLEYWMRLRFPIRSSLQAYNKRKKAQAYLAANVLGAWEAQKDEPRSGTWKNQNELRVEIIRCCGLRSRSLGAQPSPYVMYRFFTFSDHDTTIIPASSNPYFRDLARFPVLVTSDLDQYLRREALSVYVFDDEDSEPGSYLGRVQVPLLPLAQNKSIQGDFNLTDPVGEPNGSVQVQLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPQDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS", "length": 1221, "header": "tr|A0AAA9T473-1|A0AAA9T473_BOVIN Isoform 1 of X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=3 SV=1 CANONICAL=A0AAA9T473-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T473-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473/entry#A0AAA9T473-1", "sequence": { "sequence": "MIPTSKGKNTKTQPPLSRMTRDELEDSLFRLREEHMLVKELFWKQQDEIKRMRTALLRLTASGQGLRAEAAAAESSGSPLNGGGTQSGGSAPSSTSVPRCPGSSCSSSAWAPLLPAAPSLASTRDTDSSTPPGHRAEKPKRESRDRLSYTAPPTFKEHVTNEKARGEVASEPSELGHLMTSDTMQVEEPPKSPEKMWSKDENFAQRSSLESTQKATELRASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAAYETLLHKNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEEQLKDVAYGTRQLPLCLKPLPAHENEDKVDISPWHQSENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLVVGPQPLYDFTSQYVVEIDSLFLHYLQGASAQLDLHQAIASEHHTLAAGWICFDRVLETVERVHGSATLTGTGGEVFGVLEYWMRLRFPIRSSLQAYNKRKKAQAYLAANVLGAWEAQKDEPRSGTWKNQNELRVEIIRCCGLRSRSLGAQPSPYVMYRFFTFSDHDTTIIPASSNPYFRDLARFPVLVTSDLDQYLRREALSVYVFDDEDSEPGSYLGRVQVPLLPLAQNKSIQGDFNLTDPVGEPNGSVQVQLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPQDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS", "length": 1221, "header": "tr|A0AAA9T473-1|A0AAA9T473_BOVIN Isoform 1 of X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=3 SV=1 CANONICAL=A0AAA9T473-1" }, "locus": { "chromosome": "10", "start_pos": 25862286, "end_pos": 25807463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132599.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132599.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091308.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091308.1" } ] } }, { "isoform_ac": "A0AAA9T836-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473/entry#A0AAA9T836-1", "sequence": { "sequence": "TSYLLEDHTAKDLRDIDSIALMIPTSKGKNTKTQPPLSRMTRDELEDSLFRLREEHMLVKELFWKQQDEIKRMRTALLRLTASGQGLRAEAAAAEPELREPAKRRRNAEWRQRPLKHQRAPLPGLQLQFQRVGPPAPRRTQPRVHAGHRQLHTAGAPEAEKPKRESRDRLSYTAPPTFKEHVTNEKARGEVASEPSELGHLMTSDTMQVEEPPKSPEKMWSKDENFAQRSSLESTQKATELRASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAAYETLLHKNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEGILRSHGLPVSGDFNLTDPVGEPNGSVQVQLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS", "length": 938, "header": "tr|A0AAA9T836-1|A0AAA9T836_BOVIN Computationally mapped isoform of RPGR interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=4 SV=1 CANONICAL=A0AAA9T473-1" }, "locus": { "chromosome": "10", "start_pos": 25862351, "end_pos": 25807463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134697.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134697.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092001.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092001.1" } ] } }, { "isoform_ac": "A0AAA9TFD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473/entry#A0AAA9TFD4-1", "sequence": { "sequence": "MPKLCNKDVLSPNFECPSDNLLPVFSMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEGILRSHGLPVSGDFNLTDPVGEPNGSVQVQLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS", "length": 605, "header": "tr|A0AAA9TFD4-1|A0AAA9TFD4_BOVIN Computationally mapped isoform of RPGR interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=4 SV=1 CANONICAL=A0AAA9T473-1" }, "locus": { "chromosome": "10", "start_pos": 25842844, "end_pos": 25807463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120298.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120298.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096830.1" } ] } }, { "isoform_ac": "F1MII7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473/entry#F1MII7-1", "sequence": { "sequence": "VIPKSKNTKTQPPLSRMTRDELEDSLFRLREEHMLVKELFWKQQDEIKRMRTALLRLTASGQGLSGSPLNGGGTQSGGSAPSSTSVPRCPGSSCSSSAWAPLLPAAPSLASTRDTDSSTPPGHRRQRNPKESRDRLSYTAPPTFKEHVTNEKARGEVASEPSELGHLMTSDTMQVEEPPKSPEKMWSKDENFAQRSSLESTQKATELRASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAVSSTFLLPQNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEEQLKDVAYGTRQLPLCLKPLPAHENEDKVDISPWHQSENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLVVGPQPLYDFTSQYVVEIDSLFLHYLQGASAQLDLHQAIASEHHTLAAGWICFDRVLETVERVHGSATLTGTGGEVFGVLEYWMRLRFPIRSSLQAYNKRKKAQAYLAANVLGAWEAQKDEPRSGTWKNQNELRVEIIRCCGLRSRSLGAQPSPYVMYRFFTFSDHDTTIIPASSNPYFRDLARFPVLVTSDLDQYLRREALSVYVFDDEDSEPGSYLGRVQVPLLPLAQNKSIQGDFNLTDPVGEPNGSVQVQLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPQDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS", "length": 1211, "header": "tr|F1MII7-1|F1MII7_BOVIN Computationally mapped isoform of X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 OS=Bos taurus OX=9913 GN=RPGRIP1 PE=3 SV=4 CANONICAL=A0AAA9T473-1" }, "locus": { "chromosome": "10", "start_pos": 25856567, "end_pos": 25807463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006160.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006160.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006160.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006160.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ], "pmid": "" }, { "name": "retinal rod cell development", "id": "GO:0046548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046548", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T473", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T473" } ], "pmid": "" }, { "name": "ciliary tip", "id": "GO:0097542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097542", "evidence": [ { "database": 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"summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127" }, "gene_names": [ { "name": "OR9S39", "type": "recommended", "evidence": [ { "id": "A0AAA9T4A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0" } ] }, { "name": "OR9S39", "type": "synonym", "evidence": [ { "id": "NP_001377127", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T4A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 12", "type": "synonym", "evidence": [ { "id": "NP_001377127", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127" } ] }, { "name": "olfactory receptor family 9 subfamily S member 39", "type": "synonym", "evidence": [ { "id": "NP_001377127", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9S39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0", "locus": { "chromosome": "3", "start_pos": 119309529, "end_pos": 119308579, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055603", "url": "https://www.ensembl.org/id/ENSBTAG00000055603" } ] } } ], "crossref": [ { "id": "A0AAA9T4A0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4A0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15419", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15419", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615009", "url": "https://www.ncbi.nlm.nih.gov/gene/615009", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615009", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615009", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377127", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPQGNGNLSVMPLQEFVLDGFAGGLQTQSLLFALFLALYVVAVLGNLTMIMIITLDASLHSPMYFFLKNLSFVDLCYLSVIYPKALANTVSSSKVITFEGCIIQFFFFSLMGATEAFLLAVMAYDRFVAICSPLHYPISMCPSICARLVLGCYCGGCLNSILQASFTFTLPFCSSNHIDHFFCDVPPLLKLACADTTINELVMFGICGLIIVGTTLVVLTSYGYITVAILRMRSGGGRHKLFSTCGSHMTAVCLFYGTLFVMYAQPGAVQSMEQGKVVSVFYTLVIPMLNPLIYSLRNKDVKDALWRLGQRHTAT", "length": 316, "header": "tr|A0AAA9T4A0-1|A0AAA9T4A0_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9S39 PE=3 SV=1 CANONICAL=A0AAA9T4A0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0/entry#A0AAA9T4A0-1", "sequence": { "sequence": "MSPQGNGNLSVMPLQEFVLDGFAGGLQTQSLLFALFLALYVVAVLGNLTMIMIITLDASLHSPMYFFLKNLSFVDLCYLSVIYPKALANTVSSSKVITFEGCIIQFFFFSLMGATEAFLLAVMAYDRFVAICSPLHYPISMCPSICARLVLGCYCGGCLNSILQASFTFTLPFCSSNHIDHFFCDVPPLLKLACADTTINELVMFGICGLIIVGTTLVVLTSYGYITVAILRMRSGGGRHKLFSTCGSHMTAVCLFYGTLFVMYAQPGAVQSMEQGKVVSVFYTLVIPMLNPLIYSLRNKDVKDALWRLGQRHTAT", "length": 316, "header": 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"UniProtKB", "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4A0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], 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"sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4R5-1", "uniprot_ac": "A0AAA9T4R5", "uniprot_id": "A0AAA9T4R5_BOVIN", "mass": { "chemical_mass": 61736.0, "monoisotopic_mass": 61736.0 }, "refseq": { "ac": "XP_005215992", "name": "histone H4 transcription factor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215992" }, "gene_names": [ { "name": "HINFP", "type": "recommended", "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ] }, { "name": "HINFP", "type": "synonym", "evidence": [ { "id": "XP_005215992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215992" } ] }, { "name": "MIZF", "type": "synonym", "evidence": [ { "id": "XP_005215992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215992" } ] } ], "protein_names": [ { "name": "Histone H4 transcription factor", "type": "recommended", "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5/entry#names_and_taxonomy" } ] }, { "name": "Histone nuclear factor P", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5/entry#names_and_taxonomy" } ] }, { "name": "MBD2-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5/entry#names_and_taxonomy" } ] }, { "name": "Methyl-CpG-binding protein 2-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5/entry#names_and_taxonomy" } ] }, { "name": "histone H4 transcription factor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005215992", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215992" } ] } ], "function": [ { "annotation": "Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5#function" }, { "database": "UniProtKB", "id": "ARBA00055361", "url": "https://www.uniprot.org/uniprotkb/ARBA00055361#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HINFP", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5", "locus": { "chromosome": "15", "start_pos": 29709232, "end_pos": 29699175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015015", "url": "https://www.ensembl.org/id/ENSBTAG00000015015" } ] } } ], "crossref": [ { "id": "A0AAA9T4R5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T4R5", "database": "AlphaFoldDB", "categories": [] }, { "id": "511965", "url": "https://www.ncbi.nlm.nih.gov/gene/511965", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24391:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24391:SF26", "database": 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"MSRNQFPSVSEDCSRQSKQVKAMPPPGKVPRKENLGLQCEWGSCSFVCSAMEEFCEHVTQHLQQHLQGSGEEEEEEEDLLEEEFSCLWRECGFCSPDNSADLIRHVYFHCYHTKLKQWGLQALQSQADLSPCILDFQSRNLIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSLCCEYQVVGKDNNVVLCGWKGCTCTFKDRFKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHIRRQSSLDQQHFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRFRHSEARPFKCDCCDYSCKNLIDLRKHLDTHSKEPAYSCDFENCTFSARSLYSIKSHYRKVHEGDSEPRYRCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQLVRYESVELTQQLLRQPQEGSGLGASLNESSLQDIILETVPGEPGPQEEAEEEGGGGEGIALPASQGTSSPIIHVVNQTNAQGEREVVYYVLFEAPGEPPPASEPPSGGVMGELQGAAEEPEVQMV", "length": 538, "header": "tr|A0AAA9T4R5-1|A0AAA9T4R5_BOVIN Isoform 1 of Histone H4 transcription factor OS=Bos taurus OX=9913 GN=HINFP PE=4 SV=1 CANONICAL=A0AAA9T4R5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4R5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5/entry#A0AAA9T4R5-1", "sequence": { "sequence": 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"ENSBTAP00000093774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093774.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "G1/S transition of mitotic cell cycle", "id": "GO:0000082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "myoblast differentiation", "id": "GO:0045445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045445", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" }, { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R5" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 189, "end_pos": 218, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 230, "end_pos": 232 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 379, "end_pos": 381 }, { "start_pos": 440, "end_pos": 442 }, { "start_pos": 489, "end_pos": 491 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4R9-1", "uniprot_ac": "A0AAA9T4R9", "uniprot_id": "A0AAA9T4R9_BOVIN", "mass": { "chemical_mass": 275040.0, "monoisotopic_mass": 275040.0 }, "refseq": { "ac": "XP_015330755", "name": "nucleoprotein TPR isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330755" }, "gene_names": [ { "name": "TPR", "type": "recommended", "evidence": [ { "id": "A0AAA9T4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9" } ] }, { "name": "TPR", "type": "synonym", "evidence": [ { "id": "XP_015330755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330755" } ] } ], "protein_names": [ { "name": "Nucleoprotein TPR", "type": "recommended", "evidence": [ { "id": "A0AAA9T4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#names_and_taxonomy" } ] }, { "name": "Megator", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#names_and_taxonomy" } ] }, { "name": "NPC-associated intranuclear protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#names_and_taxonomy" } ] }, { "name": "Translocated promoter region protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#names_and_taxonomy" } ] }, { "name": "nucleoprotein TPR isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015330755", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330755" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TPR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9", "locus": { "chromosome": "16", "start_pos": 67386667, "end_pos": 67461860, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000060237", "url": "https://www.ensembl.org/id/ENSBTAG00000060237" } ] } } ], "crossref": [ { "id": "507869", "url": "https://www.ncbi.nlm.nih.gov/gene/507869", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012929", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012929", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR18898", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18898", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18898:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18898:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25481", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25481", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25785", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25785", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015330755", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T4R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSSGSVSRNRQRGRPMTSRSFDGSRRGSLRRAGARELPSEEVEAAARTSGSSVSSPFFDVSAASTAAAAVPGPVDMAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNSQLKALTEKNKELEVSQDRSVAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYITEDFKRLNEKLKESNATKGELQLKLDELQASDVSVKYREKRLEQEKELLHNQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRMEEQMNGLKASNENLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVDQLHRLLKSTGEASKGFQEHIIEVEESKDRMEKEMLEKIRKLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSIKLEQAMKEIQRLQEDTDKANKHSSVLERDNQRMEVQIKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKISELQVKLENALTELEQLRESRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLQASSLDDISLVSTPKRSSTSQTASTPAPVIEPAEAIEAKAALKQLQEIFENYKKEKADNEKMQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIASLKQHLSNMEVQLASQSSQRTGKGQPSNKEDMDDLLSQLRQAEEQVNDLKERLKTSTSNVEQYRAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRKAIESMEQQLSELKKTLNSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETAQKAESQLLECKASWEERERMLKDEVSKSVSRCEDLEKQNRLLHDQIEKLSDKVVSSMKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVNQQKDPDTEEYRKLLSEKEVHTKRIQQLTEELGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKENIQKELDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLSQAETKSKSLENQVENLQKTLSEKEIEARSLQEQTLELQSELARLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRMTALKSQYEGRISRLERELREHQERHLEQRDEPQEPTNKVPEQQRQITLKTTPASGERGIASMSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSIPQPILTVQQQTQATAFVQPTQQSHPQIEPTNQELSPNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQISDDTVEMPLPKKLKSVIPVGTEEEVMAEESTDGEVETQVYTQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTASSQDGQGKGDDVIVIDSDDEEEEEDENDGEHEDYEEDEDDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGESNQRAADSQNSGEGNTGTAESSFSQEISREQQPSSASERQTPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTASDASEHASQSVPMVTTSTGTLSTTNETAAGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN", "length": 2436, "header": "tr|A0AAA9T4R9-1|A0AAA9T4R9_BOVIN Isoform 1 of Nucleoprotein TPR OS=Bos taurus OX=9913 GN=TPR PE=3 SV=1 CANONICAL=A0AAA9T4R9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#A0AAA9T4R9-1", "sequence": { "sequence": "MPSSGSVSRNRQRGRPMTSRSFDGSRRGSLRRAGARELPSEEVEAAARTSGSSVSSPFFDVSAASTAAAAVPGPVDMAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNSQLKALTEKNKELEVSQDRSVAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYITEDFKRLNEKLKESNATKGELQLKLDELQASDVSVKYREKRLEQEKELLHNQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRMEEQMNGLKASNENLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVDQLHRLLKSTGEASKGFQEHIIEVEESKDRMEKEMLEKIRKLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSIKLEQAMKEIQRLQEDTDKANKHSSVLERDNQRMEVQIKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKISELQVKLENALTELEQLRESRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLQASSLDDISLVSTPKRSSTSQTASTPAPVIEPAEAIEAKAALKQLQEIFENYKKEKADNEKMQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIASLKQHLSNMEVQLASQSSQRTGKGQPSNKEDMDDLLSQLRQAEEQVNDLKERLKTSTSNVEQYRAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRKAIESMEQQLSELKKTLNSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETAQKAESQLLECKASWEERERMLKDEVSKSVSRCEDLEKQNRLLHDQIEKLSDKVVSSMKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVNQQKDPDTEEYRKLLSEKEVHTKRIQQLTEELGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKENIQKELDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLSQAETKSKSLENQVENLQKTLSEKEIEARSLQEQTLELQSELARLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRMTALKSQYEGRISRLERELREHQERHLEQRDEPQEPTNKVPEQQRQITLKTTPASGERGIASMSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRSTSPNVQPSIPQPILTVQQQTQATAFVQPTQQSHPQIEPTNQELSPNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQISDDTVEMPLPKKLKSVIPVGTEEEVMAEESTDGEVETQVYTQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTASSQDGQGKGDDVIVIDSDDEEEEEDENDGEHEDYEEDEDDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGGESNQRAADSQNSGEGNTGTAESSFSQEISREQQPSSASERQTPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTASDASEHASQSVPMVTTSTGTLSTTNETAAGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHAMGGRGGINRGNIN", "length": 2436, "header": "tr|A0AAA9T4R9-1|A0AAA9T4R9_BOVIN Isoform 1 of Nucleoprotein TPR OS=Bos taurus OX=9913 GN=TPR PE=3 SV=1 CANONICAL=A0AAA9T4R9-1" }, "locus": { "chromosome": "16", "start_pos": 67461661, "end_pos": 67398034, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133886.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133886.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091500.1" } ] } }, { "isoform_ac": "A0AAA9TLC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4R9/entry#A0AAA9TLC7-1", "sequence": { "sequence": 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"length": 2367, "header": "tr|A0AAA9TLC7-1|A0AAA9TLC7_BOVIN Computationally mapped isoform of Nucleoprotein TPR OS=Bos taurus OX=9913 GN=TPR PE=3 SV=1 CANONICAL=A0AAA9T4R9-1" }, "locus": { "chromosome": "16", "start_pos": 67461061, "end_pos": 67387671, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124479.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124479.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099240.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099240.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1746, "start_aa": "Thr", "end_pos": 1746, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1746", "evidence": [ { "id": "", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377505" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Y3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Y3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Y3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8B1AE", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Y3", "locus": { "chromosome": "29", "start_pos": 27621423, "end_pos": 27622352, 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"LRRC52", "type": "recommended", "evidence": [ { "id": "A0AAA9T502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ] }, { "name": "LRRC52", "type": "synonym", "evidence": [ { "id": "NP_001193028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193028" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 52", "type": "synonym", "evidence": [ { "id": "A0AAA9T502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat-containing protein 52 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193028", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193028" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9T502-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW3", "url": "https://www.uniprot.org/uniprotkb/E1BBW3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBW3-1", "url": "https://www.uniprot.org/uniprotkb/E1BBW3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLASDPRPGWLLFSFGMVLVSGSKCPNNCQCQDQEVICTGIQLTEYPSDIPLNTRRLYLNDNKIRFLPAMNLGLLSDLVYLDCQKNRIQEVMDYTFVGVFRLIYLDLSFNNLTFISPYSFSMLSNLLQLNISNNPHLLSLNKYTFANTSSLRYLDLRNTGLQTLDEAAFQNLITLQTLYLSGNPWKCNCFFLDFTIYLIVSHLNYPDEQNATCVEPTELAGWPITKVGNPLRYMCITNLDLQDYIFLLLISFCIFCAGTVAAWLTGVCAVLYQNACRKSSEDEVEEEEAENEDEQRVEVSRRIFHSRVDSGHDGFPQLI", "length": 320, "header": "tr|A0AAA9T502-1|A0AAA9T502_BOVIN Isoform 1 of Leucine rich repeat containing 52 OS=Bos taurus OX=9913 GN=LRRC52 PE=4 SV=1 CANONICAL=A0AAA9T502-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T502-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502/entry#A0AAA9T502-1", "sequence": { "sequence": "MSLASDPRPGWLLFSFGMVLVSGSKCPNNCQCQDQEVICTGIQLTEYPSDIPLNTRRLYLNDNKIRFLPAMNLGLLSDLVYLDCQKNRIQEVMDYTFVGVFRLIYLDLSFNNLTFISPYSFSMLSNLLQLNISNNPHLLSLNKYTFANTSSLRYLDLRNTGLQTLDEAAFQNLITLQTLYLSGNPWKCNCFFLDFTIYLIVSHLNYPDEQNATCVEPTELAGWPITKVGNPLRYMCITNLDLQDYIFLLLISFCIFCAGTVAAWLTGVCAVLYQNACRKSSEDEVEEEEAENEDEQRVEVSRRIFHSRVDSGHDGFPQLI", "length": 320, "header": "tr|A0AAA9T502-1|A0AAA9T502_BOVIN Isoform 1 of Leucine rich repeat containing 52 OS=Bos taurus OX=9913 GN=LRRC52 PE=4 SV=1 CANONICAL=A0AAA9T502-1" }, "locus": { "chromosome": "3", "start_pos": 3416012, "end_pos": 3394159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115543.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115543.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090809.1" } ] } }, { "isoform_ac": "E1BBW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502/entry#E1BBW3-1", "sequence": { "sequence": "MSLASDPRPGWLLFSFGMVLVSGSKCPNNCQCQDQEVICTGIQLTEYPSDIPLNTRRLYLNDNKIRFLPAMNLGLLSDLVYLDCQKNRIQEVMDYTFVGVFRLIYLDLSFNNLTFISPYSFSMLSNLLQLNISNNPHLLSLNKYTFANTSSLRYLDLRNTGLQTLDEAAFQNLITLQTLYLSGNPWKCNCFFLDFTIYLIVSHLNYPEIANLPGGPPAEKCEGAWLLPQSQSLPLHLPDEQNATCVEPTELAGWPITKVGNPLRYMCITNLDLQDYIFLLLISFCIFCAGTVAAWLTGVCAVLYQNACRKSSEDEVEEEEAENEDEQRVEVSRRIFHSRVDSGHDGFPQLI", "length": 351, "header": "tr|E1BBW3-1|E1BBW3_BOVIN Computationally mapped isoform of Leucine rich repeat containing 52 OS=Bos taurus OX=9913 GN=LRRC52 PE=4 SV=2 CANONICAL=A0AAA9T502-1" }, "locus": { "chromosome": "3", "start_pos": 3416012, "end_pos": 3394159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002199.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002199.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002199.3", "url": "https://www.ensembl.org/id/ENSBTAP00000002199.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536513", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536513", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M9I3-1", "protein_name": "Leucine-rich repeat-containing protein 52", "gene_name": "Lrrc52", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLASGPGPQLLLFSLGMGLVSGSKCPNNCLCQDQEVFCTNMQLMEYPLDIPLNTRRLFLSNNKITSLPALQLGLLSDLVYLDCQNNRIRELMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVRLNISNNPHLLYLNKYIFANTSSLRHLDLRNTGLQTIDHNALHHLMVLQTLYLSGNPWKCNCSFLDFTIHLLVSEIDQPDGQNATCMEPTELSGWPVAQVGNPLQYMCLTHLDHQDYIFLLLIGFCIFAAGTVAAWLTGVGAVLYQNARRKSGGDDTEDESGNRVTNQIFRSKANFSQGRFPHLI", "length": 313 }, "evidence": [ { "id": "A0AAA9T502", "url": "https://omabrowser.org/oma/group/A0AAA9T502/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YEC0-1", "protein_name": "Leucine rich repeat containing 52", "gene_name": "LRRC52", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSPAGKWQPLSLVFLLGMGMAAGDSSCPSGCSCRYLEVNCTGRQLQEFPTAIPLDTRQLILAANNVSYLPAVELSFLADLVYLDCQKNLLGDDLDFTFIGVVKLVYLDLSFNNLTQVTFSTFSQLLSLVVLKISDNPNLVAIEKDAFANNTWLRHLDVSRTGLTFLDASTVQDLPNLRFLGLSDNLWHCNCSFLDFITWMTESSVHFPARWGCATACQPCIPSSGVAQSTDRSGWAAHFSTLSHTCSHPQDTKGGTKRLAAASGDADNITCYTPEALRALKMPAAEVQLDSSCQTHLHKQDYIFLCFIGFCIFFAGTVVAWLAGICAVIYQIHSSKQEEEEEEEEKDAVT", "length": 350 }, "evidence": [ { "id": "A0AAA9T502", "url": "https://omabrowser.org/oma/group/A0AAA9T502/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5M8M9-1", "protein_name": "Leucine-rich repeat-containing protein 52", "gene_name": "Lrrc52", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHLTEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFRLIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNTGLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPAELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI", "length": 314 }, "evidence": [ { "id": "A0AAA9T502", "url": "https://omabrowser.org/oma/group/A0AAA9T502/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N7C0-1", "protein_name": "Leucine-rich repeat-containing protein 52", "gene_name": "LRRC52", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQLTEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNTRHKSSEEDEDEAGTRVEVSRRIFQTQTSSVQEFPQLI", "length": 313 }, "evidence": [ { "id": "A0AAA9T502", "url": "https://omabrowser.org/oma/group/A0AAA9T502/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" }, { "name": "potassium channel activator activity", "id": "GO:0099104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T502", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T502" }, { "id": "SM00013", "database": "SMART", "url": 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"https://www.ncbi.nlm.nih.gov/protein/XP_005219027" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T506", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C18H19orf47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506", "locus": { "chromosome": "18", "start_pos": 49679209, "end_pos": 49704734, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018859", "url": "https://www.ensembl.org/id/ENSBTAG00000018859" } ] } } ], "crossref": [ { "id": "A0AAA9T506", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T506", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018859", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018859", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09531", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09531", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531855", "url": "https://www.ncbi.nlm.nih.gov/gene/531855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DHRIQKN", "url": "https://omabrowser.org/oma/group/DHRIQKN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21359:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21359:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17740", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17740", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005219027", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T506", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T506-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX1", "url": "https://www.uniprot.org/uniprotkb/F1MTX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MTX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCSPSPLPSEIRRGASSAASRMITNSLNRDSPPGTPPRRPDTSTSKISVTVSNKMAAKSAKAAALAHREEESLSVPTKRRRVTAEMEGKYIINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGNKPTGVFSRLGATPETDEDLAWDSDNDSSSSSVLQYAGVLKKLGRAPAKASPQPALTVKAKATSSAPTAAAPTLRRLALSSRPAPERKPEALSKVSIIQRLGKPALVPEAQDSQVTSTKSKSSAEVKVTIKRTLVGPRGSSSTEGLGAQMDHAGTVSVFKRLGRRTF", "length": 386, "header": "tr|A0AAA9T506-1|A0AAA9T506_BOVIN Isoform 1 of Chromosome 18 C19orf47 homolog OS=Bos taurus OX=9913 GN=C18H19orf47 PE=4 SV=1 CANONICAL=A0AAA9T506-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T506-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506/entry#A0AAA9T506-1", "sequence": { "sequence": "MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCSPSPLPSEIRRGASSAASRMITNSLNRDSPPGTPPRRPDTSTSKISVTVSNKMAAKSAKAAALAHREEESLSVPTKRRRVTAEMEGKYIINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGNKPTGVFSRLGATPETDEDLAWDSDNDSSSSSVLQYAGVLKKLGRAPAKASPQPALTVKAKATSSAPTAAAPTLRRLALSSRPAPERKPEALSKVSIIQRLGKPALVPEAQDSQVTSTKSKSSAEVKVTIKRTLVGPRGSSSTEGLGAQMDHAGTVSVFKRLGRRTF", "length": 386, "header": "tr|A0AAA9T506-1|A0AAA9T506_BOVIN Isoform 1 of Chromosome 18 C19orf47 homolog OS=Bos taurus OX=9913 GN=C18H19orf47 PE=4 SV=1 CANONICAL=A0AAA9T506-1" }, "locus": { "chromosome": "18", "start_pos": 49704652, "end_pos": 49690168, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091508.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091508.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092905.1" } ] } }, { "isoform_ac": "F1MTX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506/entry#F1MTX1-1", "sequence": { "sequence": "MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCSPSPLPSEIRRGASSAASRMITNSLNRDSPPGTPPRRPDTSTSKISVTVSNKMAAKSAKAAALAHREEESLSVPTKRRRVTAEMEGKYIINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGNKPTGVFSRLGATPETDEDLAWDSDNDSSSSSVLQYAGVLKKLGRAPAKASPQPALTVKAKATSSAPTAAAPTLRRLALSSRPAPERKPEALSKVSIIQRLGKPALVPEAQDSQVTSTKSPTVRCVLPDPPAPPASQRRPRRRWRRASRDC", "length": 370, "header": "tr|F1MTX1-1|A0AAA9T506_BOVIN Computationally mapped isoform of Chromosome 18 C19orf47 homolog OS=Bos taurus OX=9913 GN=C18H19orf47 PE=4 SV=2 CANONICAL=A0AAA9T506-1" }, "locus": { "chromosome": "18", "start_pos": 49704652, "end_pos": 49689552, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025109.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025109.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025109.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025109.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 119, "start_aa": "Thr", "end_pos": 119, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr119", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BD09-1", "protein_name": "Chromosome 6 C19orf47 homolog", "gene_name": "C19orf47", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCGPSPLPGETRRGTSSAASRMITNSLNRDSPPGTPPRRPDTSTSKISVTVPNKMAAKSAKAAAALARCEEESLAVPTKRRRVTAEMEGKYIINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGNKPTGVFSRLGATPEMDEDLAWDSDNDSSSSVLQYAGVLKKLGRAPAKASHQPTLTVKAKATSSAPTAATPTLRRLALSSRPGLEKKPEPLSKVSVIQRLGKTALVPEAQDSQVTSTKSKSSAEVKVTIKRTLVGPRGNSSSEGLGAQMDHAGTVSVFKRLGRRTF", "length": 386 }, "evidence": [ { "id": "A0AAA9T506", "url": "https://omabrowser.org/oma/group/A0AAA9T506/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0JPQ7-1", "protein_name": "Uncharacterized protein C19orf47 homolog", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFRIRESLLLNLRKVPGSRVKARETMVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATASVPCTPSPLQGELRRGASSAASRMIANSLNHDSPPHTPARRSDNSTSKISVTVSNKVAVKNAKAAALAHREEESLVVPTKRRRVTAEMEGKYIIHMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGTKPTGVFSRLGATPEMDEELAWDSDNDSSSSSVLQYAGVLKKLGRGPTKASPQPALTVKAKATSSATTLASTPKLRRLALPSRPGPEKKPESLPKVSILKRLGKAAVVSEAQDSQVTSTKSPTVRCIVPDPPAPLASQRPPRRRWRRTCKDC", "length": 397 }, "evidence": [ { "id": "A0AAA9T506", "url": "https://omabrowser.org/oma/group/A0AAA9T506/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N9M1-1", "protein_name": "Uncharacterized protein C19orf47", "gene_name": "C19orf47", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVMAALSLVAACWGRAAADESVQLPAAPGSSVRARETMVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCSPSPLAGEIRRGTSAASRMITNSLNHDSPPSTPPRRPDTSTSKISVTVSNKMAAKSAKATAALARREEESLAVPAKRRRVTAEMEGKYVINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTTGSKPTGVFSRLGATPETDEDLAWDSDNDSSSSVLQYAGVLKKLGRGPAKASPQPALTVKAKATSSATTAAAPTLRRLALSSRSGLERKPESLSKVSIIKRLGAAALVPEAQDSQVTSTKSKSSAEVKVTIKRTLVGPRGSSSSEGLGAQMDHAGTVSVFKRLGRRTF", "length": 422 }, "evidence": [ { "id": "A0AAA9T506", "url": "https://omabrowser.org/oma/group/A0AAA9T506/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R3Y5-1", "protein_name": "Uncharacterized protein C19orf47 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFRIGKNLLFNLRKAPGSRVKARKTMVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCNPSPLQGELRRGASSAASRMIANSLNHDSPPHTPTRRSDNSTSKISVTVSNKMAAKSAKAAALAHREEESLVVPTKRRRVTAEMEGKYIIHMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAESKADTTTGTKPTGVFSRLGATPEMDEDLAWDSDNDSSSSSVLQYAGVLKKLGRGPTKASAQPALTVKAKAASSATSTATTPKLRRLALPSRPGLQKKPDSLPKVSILQRLGKAAVVSEAQDSQVTSTKSKSSAEVKFAIKRTLVGPRGSSSSESLGAQMDHAGTVSVFKRLGQRTF", "length": 413 }, "evidence": [ { "id": "A0AAA9T506", "url": "https://omabrowser.org/oma/group/A0AAA9T506/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T506", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T506" }, { "id": "PF17740", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17740" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF5577", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 382, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 119 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T509-1", "uniprot_ac": "A0AAA9T509", "uniprot_id": "A0AAA9T509_BOVIN", "mass": { "chemical_mass": 29841.0, "monoisotopic_mass": 29841.0 }, "refseq": {}, "gene_names": [ { "name": "OLAH", "type": "recommended", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ] } ], "protein_names": [ { "name": "S-acyl fatty acid synthase thioesterase, medium chain", "type": "recommended", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.14", "type": "synonym", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#names_and_taxonomy" } ] }, { "name": "Oleoyl-ACP hydrolase", "type": "synonym", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#names_and_taxonomy" } ] }, { "name": "Thioesterase II", "type": "synonym", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#names_and_taxonomy" } ] }, { "name": "Thioesterase domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509#function" }, { "database": "UniProtKB", "id": "ARBA00053731", "url": "https://www.uniprot.org/uniprotkb/ARBA00053731#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OLAH", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509", "locus": { "chromosome": "13", "start_pos": 29653202, "end_pos": 29624936, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057441", "url": "https://www.ensembl.org/id/ENSBTAG00000057441" } ] } } ], "crossref": [ { "id": "A0AAA9T509", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T509", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11487", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11487", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11487:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11487:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00975", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00975", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "15057", "url": "https://www.rhea-db.org/rhea/15057", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16645", "url": "https://www.rhea-db.org/rhea/16645", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30135", "url": "https://www.rhea-db.org/rhea/30135", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40059", "url": "https://www.rhea-db.org/rhea/40059", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40119", "url": "https://www.rhea-db.org/rhea/40119", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T509-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERRNKAETIRNEKVVNCLYQNRNALFRLVCFPWGGGDSTYFAKWGQDIPNSVEVHAIRLAGRESRLEEPFASDMNQIVDEIACALLPIIQGEYFAFFGHSMGSFTAFFTALHLKEKYNLEPVHLFVSSLSPPHSKARIHLHKDDLCKEEIFYVMKKVGGIPDKFFDKKMSPEFVTRLLADLHILNDVTSDIPSKTRLSCDITCFSGSEDIPLDMEAWKDVTSGSFDSFVLPGNHFYLMEPSNTSFIKKYITKTLEISAFTS", "length": 262, "header": "tr|A0AAA9T509-1|A0AAA9T509_BOVIN Isoform 1 of S-acyl fatty acid synthase thioesterase, medium chain OS=Bos taurus OX=9913 GN=OLAH PE=3 SV=1 CANONICAL=A0AAA9T509-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T509-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509/entry#A0AAA9T509-1", "sequence": { "sequence": "MERRNKAETIRNEKVVNCLYQNRNALFRLVCFPWGGGDSTYFAKWGQDIPNSVEVHAIRLAGRESRLEEPFASDMNQIVDEIACALLPIIQGEYFAFFGHSMGSFTAFFTALHLKEKYNLEPVHLFVSSLSPPHSKARIHLHKDDLCKEEIFYVMKKVGGIPDKFFDKKMSPEFVTRLLADLHILNDVTSDIPSKTRLSCDITCFSGSEDIPLDMEAWKDVTSGSFDSFVLPGNHFYLMEPSNTSFIKKYITKTLEISAFTS", "length": 262, "header": "tr|A0AAA9T509-1|A0AAA9T509_BOVIN Isoform 1 of S-acyl fatty acid synthase thioesterase, medium chain OS=Bos taurus OX=9913 GN=OLAH PE=3 SV=1 CANONICAL=A0AAA9T509-1" }, "locus": { "chromosome": "13", "start_pos": 29652198, "end_pos": 29626082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111295.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111295.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090815.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090815.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "medium-chain fatty acid biosynthetic process", "id": "GO:0051792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051792", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "fatty acyl-[ACP] hydrolase activity", "id": "GO:0016297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T509", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15057", "name": "", "equation": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T509-1" ], "evidence": [ { "id": "15057", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15057" } ] }, { "id": "16645", "name": "", "equation": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4L1-1", "A5PJT0-1", "Q3T0R7-1", "A0ABI0P2S3-1", "Q3SWX2-1", "P45478-1", "F6RWU6-1", "A0A3Q1M171-1", "F6QGE6-1", "Q1JQA0-1", "A0AAA9T509-1", "E1BB89-1", "A0AAA9SCF5-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "30135", "name": "", "equation": "dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4L1-1", "A5PJT0-1", "Q3T0R7-1", "A0ABI0P2S3-1", "F6RWU6-1", "A0A3Q1M171-1", "F6QGE6-1", "A0AAA9T509-1" ], "evidence": [ { "id": "30135", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30135" } ] }, { "id": "40059", "name": "", "equation": "decanoyl-CoA + H2O = decanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4L1-1", "Q3T0R7-1", "A0ABI0P2S3-1", "Q3SWX2-1", "F6RWU6-1", "F6QGE6-1", "A0AAA9T509-1" ], "evidence": [ { "id": "40059", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40059" } ] }, { "id": "40119", "name": "", "equation": "tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4L1-1", "A5PJT0-1", "Q3T0R7-1", "A0ABI0P2S3-1", "Q3SWX2-1", "F6RWU6-1", "A0A3Q1M171-1", "F6QGE6-1", "A0AAA9T509-1" ], "evidence": [ { "id": "40119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40119" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M171", "gene_name": "ACOT11", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0A3Q1M171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1M171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M171" } ] } ] }, { "uniprot_ac": "A0AAA9SCF5", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] } ] }, { "uniprot_ac": "A0AAA9T509", "gene_name": "OLAH", "activity": [ { "ec_number": "3.1.2.14", "activity": "hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+).", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "A0AAA9T509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T509" } ] } ] }, { "uniprot_ac": "A0ABI0P2S3", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0ABI0P2S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2S3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0ABI0P2S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2S3" } ] } ] }, { "uniprot_ac": "A1A4L1", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A1A4L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4L1" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A1A4L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4L1" } ] } ] }, { "uniprot_ac": "A5PJT0", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A5PJT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJT0" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "F6QGE6", "gene_name": "ACOT13", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6QGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGE6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6QGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QGE6" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "P45478", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] } ] }, { "uniprot_ac": "Q1JQA0", "gene_name": "PPT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q1JQA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q1JQA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA0" } ] } ] }, { "uniprot_ac": "Q3SWX2", "gene_name": "ACOT9", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3SWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWX2" } ] } ] }, { "uniprot_ac": "Q3T0R7", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q3T0R7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0R7" } ] }, { "ec_number": "2.3.1.16", 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"MGLPLLNISHTWNQTEPVAGEAAEQGQAGPCPSGRPSPSPAPAPGSPPGSPAGPAMTSEPTPPAVVPPLHSPKSPVWPTFPFHREGSRVWERGSVSSRDLPSPLPTKRTRTYSATARASAGPVFKGICKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKVCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS", "length": 208, "header": "tr|G3X6D8-1|G3X6D8_BOVIN Computationally mapped isoform of Cold shock domain containing C2 OS=Bos taurus OX=9913 GN=CSDC2 PE=4 SV=2 CANONICAL=A0AAA9T513-1" }, "locus": { "chromosome": "5", "start_pos": 112652767, "end_pos": 112646766, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005226.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005226.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005226.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005226.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 49, "start_aa": "Thr", "end_pos": 49, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr49", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P545-1", "protein_name": "Cold shock domain containing C2", "gene_name": "CSDC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSEPGAPPAVPPLHSPKSPVWPTFPFQREGSRVWERGNLLLRDLPSPLPTKRTRTYSATARASAGPIYKGVCKQFSRSQGHGFITPENGTEDIFVHVSDIEGEYVPVEGDEVTYKVCPIPPKNQKFQAVEVVLTNLAPHTKHETWSGQIIGS", "length": 153 }, "evidence": [ { "id": "A0AAA9T513", "url": "https://omabrowser.org/oma/group/A0AAA9T513/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1W4K0-1", "protein_name": "Cold shock domain containing C2", "gene_name": "CSDC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSEPTPPPVVPPLHSPKSPVWPTFPFHREGSRVWERGGVSSRDLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS", "length": 153 }, "evidence": [ { "id": "A0AAA9T513", "url": "https://omabrowser.org/oma/group/A0AAA9T513/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FIC6-1", "protein_name": "Cold shock domain-containing protein C2 isoform X1", "gene_name": "Csdc2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPEDFETTTESIPGEATEQGKAGPCPKGRQSPSPAPVSQSPPGSRAGATMTSEPTSPPVVPPLHSPKSPVWPTFPFHREGSRIWERGGGISPRDLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS", "length": 203 }, "evidence": [ { "id": "A0AAA9T513", "url": "https://omabrowser.org/oma/group/A0AAA9T513/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q63430-1", "protein_name": "Cold shock domain-containing protein C2", "gene_name": "Csdc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSESTSPPVVPPLHSPKSPVWPTFPFHRESSRIWERGGGVSPRDLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS", "length": 154 }, "evidence": [ { "id": "A0AAA9T513", "url": "https://omabrowser.org/oma/group/A0AAA9T513/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91YQ3-1", "protein_name": "Cold shock domain-containing protein C2", "gene_name": "Csdc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSESTLPPVVPPLHSPKSPVWPTFPFHREGSRIWERGGGIAPRDLPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIEGEYVPVEGDEVTYKICPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS", "length": 154 }, "evidence": [ { 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"MVQKERPGRERFDIYRKVPKDLTQPTYTGAIISVCCCLFILFLFLSELTGFITTEIVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVHNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQQFSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH", "length": 294, "header": "tr|A0AAA9T3D4-1|A0AAA9T3D4_BOVIN Isoform 1 of Endoplasmic reticulum-Golgi intermediate compartment protein OS=Bos taurus OX=9913 GN=ERGIC1 PE=3 SV=1 CANONICAL=A0AAA9T3D4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4/entry#A0AAA9RZC4-1", "sequence": { "sequence": "MPFDFRRFDIYRKVPKDLTQPTYTGAIISVCCCLFILFLFLSELTGFITTEIVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVHNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQQFSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTTVPFPRALQAGLPAGAK", "length": 272, "header": "tr|A0AAA9RZC4-1|A0AAA9T3D4_BOVIN Computationally mapped isoform of Endoplasmic reticulum-Golgi intermediate compartment protein OS=Bos taurus OX=9913 GN=ERGIC1 PE=3 SV=1 CANONICAL=A0AAA9T3D4-1" }, "locus": { "chromosome": "20", "start_pos": 4703099, "end_pos": 4596633, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101889.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101889.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075141.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075141.1" } ] } }, { "isoform_ac": "A0AAA9T3D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4/entry#A0AAA9T3D4-1", "sequence": { "sequence": "MVQKERPGRERFDIYRKVPKDLTQPTYTGAIISVCCCLFILFLFLSELTGFITTEIVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVHNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQQFSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH", "length": 294, "header": "tr|A0AAA9T3D4-1|A0AAA9T3D4_BOVIN Isoform 1 of Endoplasmic reticulum-Golgi intermediate compartment protein OS=Bos taurus OX=9913 GN=ERGIC1 PE=3 SV=1 CANONICAL=A0AAA9T3D4-1" }, "locus": { "chromosome": "20", "start_pos": 4707687, "end_pos": 4629097, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126083.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126083.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092281.1" } ] } }, { "isoform_ac": "A0AAA9TMY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4/entry#A0AAA9TMY7-1", "sequence": { "sequence": "MPFDFRRFDIYRKVPKDLTQPTYTGAIISVCCCLFILFLFLSELTGFITTEIVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVHNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQQFSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH", "length": 290, "header": "tr|A0AAA9TMY7-1|A0AAA9T3D4_BOVIN Computationally mapped isoform of Endoplasmic reticulum-Golgi intermediate compartment protein OS=Bos taurus OX=9913 GN=ERGIC1 PE=3 SV=2 CANONICAL=A0AAA9T3D4-1" }, "locus": { "chromosome": "20", "start_pos": 4707687, "end_pos": 4596633, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132014.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132014.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099877.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099877.2" } ] } }, { "isoform_ac": "F6QNX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4/entry#F6QNX4-1", "sequence": { "sequence": "MGRSVSVCCCLFILFLFLSELTGFITTEIVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGVGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHIIHKLSFGDTLQVHNVHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQQFSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH", "length": 267, "header": "tr|F6QNX4-1|F6QNX4_BOVIN Computationally mapped isoform of Endoplasmic reticulum-Golgi intermediate compartment protein OS=Bos taurus OX=9913 GN=ERGIC1 PE=3 SV=3 CANONICAL=A0AAA9T3D4-1" }, "locus": { "chromosome": "20", "start_pos": 4707687, "end_pos": 4656898, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021218.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021218.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021218.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021218.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" }, { "name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "id": "GO:0006890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006890", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" }, { "id": "PF07970", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07970" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Endoplasmic reticulum vesicle transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 275, "start_aa": "Asn", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T3D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3D4" }, { "id": "PF13850", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Endoplasmic reticulum vesicle transporter N-terminal", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 101, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T3W0-1", "uniprot_ac": "A0AAA9T3W0", "uniprot_id": "A0AAA9T3W0_BOVIN", "mass": { "chemical_mass": 40277.0, "monoisotopic_mass": 40277.0 }, "refseq": {}, "gene_names": [ { "name": "SPO11", "type": "recommended", "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ] } ], "protein_names": [ { "name": "DNA topoisomerase (ATP-hydrolyzing)", "type": "recommended", "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0/entry#names_and_taxonomy" } ] }, { "name": "5.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.", "evidence": [ { "database": "UniProtKB", "id": "E1BMM6", "url": "https://www.uniprot.org/uniprotkb/E1BMM6#function" }, { "database": "UniProtKB", "id": "ARBA00059173", "url": "https://www.uniprot.org/uniprotkb/ARBA00059173#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPO11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0", "locus": { "chromosome": "13", "start_pos": 58812692, "end_pos": 58828236, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044210", "url": "https://www.ensembl.org/id/ENSBTAG00000044210" } ] } } ], "crossref": [ { "id": "A0AAA9T3W0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T3W0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044210", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044210", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00223", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00223", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BMM6", "url": "https://www.orthodb.org/?gene=E1BMM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10848", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10848", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10848:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10848:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03533", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03533", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04406", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04406", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21180", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21180", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3W0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMM6", "url": "https://www.uniprot.org/uniprotkb/E1BMM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMM6-1", "url": "https://www.uniprot.org/uniprotkb/E1BMM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFTPRGPEASFFEVLDRHRASLLAALRRGGEEPAGGGMRLASRFEDSVGLHMVSHCTTRKIKSDSPKSVKNFALILKIFSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVPRRSLHILSTSKGLIAGDLKYLEEDGTKVNCTRATAVAVPSNIQGIQNLITDAKFLLIVEKDATFQRLLDDNFCNKMSPCIMVTGKGVPDVNTRLLIKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMAMSFEAHNLTVPAIRWLGLLPSDIKRLNIPKGTLIPLTKRDQMKLDSILKRPYITCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI", "length": 357, "header": "tr|A0AAA9T3W0-1|A0AAA9T3W0_BOVIN Isoform 1 of DNA topoisomerase (ATP-hydrolyzing) OS=Bos taurus OX=9913 GN=SPO11 PE=3 SV=1 CANONICAL=A0AAA9T3W0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3W0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0/entry#A0AAA9T3W0-1", "sequence": { "sequence": "MAFTPRGPEASFFEVLDRHRASLLAALRRGGEEPAGGGMRLASRFEDSVGLHMVSHCTTRKIKSDSPKSVKNFALILKIFSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVPRRSLHILSTSKGLIAGDLKYLEEDGTKVNCTRATAVAVPSNIQGIQNLITDAKFLLIVEKDATFQRLLDDNFCNKMSPCIMVTGKGVPDVNTRLLIKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMAMSFEAHNLTVPAIRWLGLLPSDIKRLNIPKGTLIPLTKRDQMKLDSILKRPYITCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI", "length": 357, "header": "tr|A0AAA9T3W0-1|A0AAA9T3W0_BOVIN Isoform 1 of DNA topoisomerase (ATP-hydrolyzing) OS=Bos taurus OX=9913 GN=SPO11 PE=3 SV=1 CANONICAL=A0AAA9T3W0-1" }, "locus": { "chromosome": "13", "start_pos": 58828073, "end_pos": 58813696, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132668.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132668.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093488.1" } ] } }, { "isoform_ac": "E1BMM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0/entry#E1BMM6-1", "sequence": { "sequence": "MAFTPRGPEASFFEVLDRHRASLLAALRRGGEEPAGGGMRLASSSEVLSSIEKIIQDIVTSLARNEAPAFTIDNRSSWENIKFEDSVGLHMVSHCTTRKIKSDSPKSVKNFALILKIFSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVPRRSLHILSTSKGLIAGDLKYLEEDGTKVNCTRATAVAVPSNIQGIQNLITDAKFLLIVEKDATFQRLLDDNFCNKMSPCIMVTGKGVPDVNTRLLIKKLWDTFHIPVFTLVDADPHGIEIMCIYKYGSMAMSFEAHNLTVPAIRWLGLLPSDIKRLNIPKGTLIPLTKRDQMKLDSILKRPYITCQPFWRKEMAAHQASPSLGFSRQEHWSGYLHHILKLFFLNFYITSNCYVHCLAVNCC", "length": 405, "header": "tr|E1BMM6-1|E1BMM6_BOVIN Computationally mapped isoform of Meiotic recombination protein SPO11 OS=Bos taurus OX=9913 GN=SPO11 PE=3 SV=3 CANONICAL=A0AAA9T3W0-1" }, "locus": { "chromosome": "13", "start_pos": 58828073, "end_pos": 58814148, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061470.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061470.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053612.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053612.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "id": "GO:0003918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003918", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "nuclear chromosome", "id": "GO:0000228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "meiotic DNA double-strand break formation", "id": "GO:0042138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042138", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "meiotic DNA double-strand break processing", "id": "GO:0000706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000706", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" }, { "name": "female gamete generation", "id": "GO:0007292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007292", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T3W0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" }, { "id": "PF03533", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03533" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Meiosis-specific protein Spo11", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 43, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" }, { "id": "PF04406", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spo11/DNA topoisomerase VI subunit A N-terminal", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 132, "start_aa": "Lys", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T3W0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3W0" }, { "id": "PF21180", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Topoisomerase 6 subunit A/Spo11 TOPRIM", "eco_id": "ECO_0000259", "start_pos": 180, "end_pos": 351, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "5.6.2.2", "ec_name": "ATP-dependent breakage, passage and rejoining of double-stranded DNA.", "evidence": [ { "id": "5.6.2.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.6.2.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 263, "end_pos": 265 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4E5-1", "uniprot_ac": "A0AAA9T4E5", "uniprot_id": "A0AAA9T4E5_BOVIN", "mass": { "chemical_mass": 164921.0, "monoisotopic_mass": 164921.0 }, "refseq": {}, "gene_names": [ { "name": "LTBP4", "type": "recommended", "evidence": [ { "id": "A0AAA9T4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ] } ], "protein_names": [ { "name": "Latent-transforming growth factor beta-binding protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9T4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. 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[9913]" } ], "gene": [ { "name": "LTBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5", "locus": { "chromosome": "18", "start_pos": 49925139, "end_pos": 49894671, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004757", "url": "https://www.ensembl.org/id/ENSBTAG00000004757" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004757", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004757", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050751", "database": "InterPro", "categories": [ "Protein 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"Other" ] }, { "id": "R-BTA-2129379", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2129379", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173789", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA44", "url": "https://www.uniprot.org/uniprotkb/E1BA44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA44-1", "url": "https://www.uniprot.org/uniprotkb/E1BA44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZT8", "url": "https://www.uniprot.org/uniprotkb/G3MZT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZT8-1", "url": "https://www.uniprot.org/uniprotkb/G3MZT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGGARLLWVSLLVLLALLRPQPGLGRPRERLRVRFTPAVCGLSCVHGPTGPRCTPTCAPRNTTSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAMPGFTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARSEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQSCSELLGNTHQGGAPDGPCPTGFERVNGSCEDVDECATRGRCQHGECANTHGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRAPPSTSRPPSGFLPTHRPEPRPEPRPGPELPLPSIPAWTGPGIPESGPSAGECQRNPQVCGRGRCIPRPSGYTCACDSGFRLSPQGTHCIDVDECRRVPTPCAPGRCENTPGSFRCVCGPGFRAGPRGTECLDVDECHRVPPPCDRGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECIQSPGLCGRGVCENLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTVGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCAYGRCENTEGGFQCVCPTGFQPNAAGSECEDVDECENHLACPGQECVNSPGSFQCRACPAGHHLHHGRCTDVDECSSGASCGPHGHCTNTEGSFHCSCEPGYRAPVGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDIDECQEYGPAICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPRTSAGTFPGAQPHAPASPSLPARPPPPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPSTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHAQRLECIDNDECADEEPACEGGRCVNTIGSYHCTCEPPLVLDGSRRRCVSNESQSLDDNLGVCWQEVGADLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYGPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPVLPYDPYPPPPGPFARREAPYGTPPFDMPDFEDDGGPYGESEAPAPSGPGTRWRYRSRDTRGSFPEPEESPEGGSYAGAQAGRYEGLEAEECGILDGCAHGRCVRVPEGFTCDCFDGYRLDMTRMSCVDINECDEAEAAAPLCVNARCVNTDGSFRCICRPGFAPSHEPHHCTPARPRA", "length": 1551, "header": "tr|A0AAA9T4E5-1|A0AAA9T4E5_BOVIN Isoform 1 of Latent-transforming growth factor beta-binding protein 4 OS=Bos taurus OX=9913 GN=LTBP4 PE=3 SV=1 CANONICAL=A0AAA9T4E5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5/entry#A0AAA9T4E5-1", "sequence": { "sequence": "MAGGARLLWVSLLVLLALLRPQPGLGRPRERLRVRFTPAVCGLSCVHGPTGPRCTPTCAPRNTTSVDSGAPGGAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAMPGFTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARSEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQSCSELLGNTHQGGAPDGPCPTGFERVNGSCEDVDECATRGRCQHGECANTHGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRAPPSTSRPPSGFLPTHRPEPRPEPRPGPELPLPSIPAWTGPGIPESGPSAGECQRNPQVCGRGRCIPRPSGYTCACDSGFRLSPQGTHCIDVDECRRVPTPCAPGRCENTPGSFRCVCGPGFRAGPRGTECLDVDECHRVPPPCDRGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECIQSPGLCGRGVCENLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTVGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCAYGRCENTEGGFQCVCPTGFQPNAAGSECEDVDECENHLACPGQECVNSPGSFQCRACPAGHHLHHGRCTDVDECSSGASCGPHGHCTNTEGSFHCSCEPGYRAPVGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDIDECQEYGPAICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPRTSAGTFPGAQPHAPASPSLPARPPPPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPSTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHAQRLECIDNDECADEEPACEGGRCVNTIGSYHCTCEPPLVLDGSRRRCVSNESQSLDDNLGVCWQEVGADLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYGPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPVLPYDPYPPPPGPFARREAPYGTPPFDMPDFEDDGGPYGESEAPAPSGPGTRWRYRSRDTRGSFPEPEESPEGGSYAGAQAGRYEGLEAEECGILDGCAHGRCVRVPEGFTCDCFDGYRLDMTRMSCVDINECDEAEAAAPLCVNARCVNTDGSFRCICRPGFAPSHEPHHCTPARPRA", "length": 1551, "header": "tr|A0AAA9T4E5-1|A0AAA9T4E5_BOVIN Isoform 1 of Latent-transforming growth factor beta-binding protein 4 OS=Bos taurus OX=9913 GN=LTBP4 PE=3 SV=1 CANONICAL=A0AAA9T4E5-1" }, "locus": { "chromosome": "18", "start_pos": 49924386, "end_pos": 49901622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103701.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103701.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093654.1" } ] } }, { "isoform_ac": "E1BA44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5/entry#E1BA44-1", "sequence": { "sequence": "ALKVLLLVAAVQADRPGEAAALESLAVSEASCRVRSCRPEKCAGLQRCLAPGPPELQSASPSVRKRQVSLNWQPLTLQEARALLRRRRPRGPGARALLRRRPPQRAPAGQSRVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAMPGFTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARSEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQSCSELLGNTHQGGAPDGPCPTGFERVNGSCEDVDECATRGRCQHGECANTHGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRAPPSTSRPPSGFLPTHRPEPRPEPRPGPELPLPSIPAWTGPGIPESGPSAGECQRNPQVCGRGRCIPRPSGYTCACDSGFRLSPQGTHCIDVDECRRVPTPCAPGRCENTPGSFRCVCGPGFRAGPRGTECLDVDECHRVPPPCDRGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECIQSPGLCGRGVCENLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTVGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCAYGRCENTEGGFQCVCPTGFQPNAAGSECEDVDECENHLACPGQECVNSPGSFQCRACPAGHHLHHGRCTDVDECSSGASCGPHGHCTNTEGSFHCSCEPGYRAPVGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDIDECQEYGPAICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPRTSAGTFPGAQPHAPASPSLPARPPPPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPSTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHAQRLECIDNDECADEEPACEGGRCVNTIGSYHCTCEPPLVLDGSRRRCVSNESQSLDDNLGVCWQEVGADLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYGPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPVLPYDPYPPPPGPFARREAPYGTPPFDMPDFEDDGGPYGESEAPAPSGPGTRWRYRSRDTRGSFPEPEESPEGGSYAGAQAGRYEGLEAEECGILDGCAHGRCVRVPEGFTCDCFDGYRLDMTRMSCVDINECDEAEAAAPLCVNARCVNTDGSFRCICRPGFAPSHEPHHCTPARPRA", "length": 1580, "header": "tr|E1BA44-1|E1BA44_BOVIN Computationally mapped isoform of Latent-transforming growth factor beta-binding protein 4 OS=Bos taurus OX=9913 GN=LTBP4 PE=3 SV=4 CANONICAL=A0AAA9T4E5-1" }, "locus": { "chromosome": "18", "start_pos": 49924386, "end_pos": 49894671, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006244.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006244.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006244.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006244.6" } ] } }, { "isoform_ac": "G3MZT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5/entry#G3MZT8-1", "sequence": { "sequence": "MRLPGPSGRRPLLLVLLLPLLAAAATAASAAGPSTSQAVEVAAIPGRPAGAPACRCCPSRSPRRSRCFRASCRVRSCRPEKCAGLQRCLAPGPPELQSASPSVRKRQVSLNWQPLTLQEARALLRRRRPRGPGARALLRRRPPQRAPAGQSRVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAMPGFTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARSEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQSCSELLGNTHQGGAPDGPCPTGFERVNGSCEDVDECATRGRCQHGECANTHGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRAPPSTSRPPSGFLPTHRPEPRPEPRPGPELPLPSIPAWTGPGIPESGPSAGECQRNPQVCGRGRCIPRPSGYTCACDSGFRLSPQGTHCIDVDECRRVPTPCAPGRCENTPGSFRCVCGPGFRAGPRGTECLDVDECHRVPPPCDRGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECIQSPGLCGRGVCENLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTVGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCAYGRCENTEGGFQCVCPTGFQPNAAGSECEDVDECENHLACPGQECVNSPGSFQCRACPAGHHLHHGRCTDVDECSSGASCGPHGHCTNTEGSFHCSCEPGYRAPVGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDIDECQEYGPAICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPRTSAGTFPGAQPHAPASPSLPARPPPPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPSTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHAQRLECIDNDECADEEPACEGGRCVNTIGSYHCTCEPPLVLDGSRRRCVSNESQSLDDNLGVCWQEVGADLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYGPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPVLPYDPYPPPPGPFARREAPYGTPPFDMPDFEDDGGPYGESEAPAPSGPGTRWRYRSRDTRGSFPEPEESPEGGSYAGAQAGRYEGLEAEECGILDGCAHGRCVRVPEGFTCDCFDGYRLDMTRMSCVDINECDEAEAAAPLCVNARCVNTDGSFRCICRPGFAPSHEPHHCTPARPRA", "length": 1620, "header": "tr|G3MZT8-1|G3MZT8_BOVIN Computationally mapped isoform of Latent-transforming growth factor beta-binding protein 4 OS=Bos taurus OX=9913 GN=LTBP4 PE=3 SV=3 CANONICAL=A0AAA9T4E5-1" }, "locus": { "chromosome": "18", "start_pos": 49924386, "end_pos": 49897503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065855.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065855.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055091.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055091.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 970, "start_aa": "Thr", "end_pos": 970, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr970", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2129379", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2129379", "resource": "Reactome", "description": "Molecules associated with elastic fibres" }, { "id": "R-BTA-2173789", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "resource": "Reactome", "description": "TGF-beta receptor signaling activates SMADs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "growth factor binding", "id": "GO:0019838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019838", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" }, { "name": "transforming growth factor beta binding", "id": "GO:0050431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" }, { "name": "microfibril", "id": "GO:0001527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001527", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1127, "end_pos": 1129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1266, "end_pos": 1268, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 983, "end_pos": 985, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 82, "end_pos": 114, "start_aa": "Arg", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T4E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4E5" }, { "id": "PS51364", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51364" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TB", "eco_id": "ECO_0000259", "start_pos": 220, "end_pos": 260, "start_aa": "Gly", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 970 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1127, "end_pos": 1129 }, { "start_pos": 1266, "end_pos": 1268 }, { "start_pos": 285, "end_pos": 287 }, { "start_pos": 358, "end_pos": 360 }, { "start_pos": 62, "end_pos": 64 }, { "start_pos": 983, "end_pos": 985 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T1U3-1", "uniprot_ac": "A0AAA9T1U3", "uniprot_id": "A0AAA9T1U3_BOVIN", "mass": { "chemical_mass": 52079.0, "monoisotopic_mass": 52079.0 }, "refseq": {}, "gene_names": [ { "name": "DOK1", "type": "recommended", "evidence": [ { "id": "A0AAA9T1U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ] } ], "protein_names": [ { "name": "Docking protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T1U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.", "evidence": [ { "database": "UniProtKB", "id": "F1MRT5", "url": "https://www.uniprot.org/uniprotkb/F1MRT5#function" }, { "database": "UniProtKB", "id": "ARBA00060309", "url": "https://www.uniprot.org/uniprotkb/ARBA00060309#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DOK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3", "locus": { "chromosome": "11", "start_pos": 10085663, "end_pos": 10103196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018579", "url": "https://www.ensembl.org/id/ENSBTAG00000018579" } ] } } ], "crossref": [ { "id": "A0AAA9T1U3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T1U3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018579", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018579", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14676", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14676", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037751", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037751", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFFDCKE", "url": "https://omabrowser.org/oma/group/EFFDCKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MRT5", "url": "https://www.orthodb.org/?gene=F1MRT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21258:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21258:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8849469", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849469", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRT5", "url": "https://www.uniprot.org/uniprotkb/F1MRT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MRT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASWGNQPAETAAPGSQPSSQRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST", "length": 484, "header": "tr|A0AAA9T1U3-1|A0AAA9T1U3_BOVIN Isoform 1 of Docking protein 1 OS=Bos taurus OX=9913 GN=DOK1 PE=3 SV=1 CANONICAL=A0AAA9T1U3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3/entry#A0AAA9T1U3-1", "sequence": { "sequence": "MASWGNQPAETAAPGSQPSSQRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST", "length": 484, "header": "tr|A0AAA9T1U3-1|A0AAA9T1U3_BOVIN Isoform 1 of Docking protein 1 OS=Bos taurus OX=9913 GN=DOK1 PE=3 SV=1 CANONICAL=A0AAA9T1U3-1" }, "locus": { "chromosome": "11", "start_pos": 10091175, "end_pos": 10086124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130927.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130927.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090524.1" } ] } }, { "isoform_ac": "F1MRT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3/entry#F1MRT5-1", "sequence": { "sequence": "MGTPPASPAPPRPAPPPGPPGQEARKEPPGAMDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSAAWVQTLCQNAFPKGSWALAPAENPPKLSALEMLENSLYSPSWEGSQFWVTVQKTEAAERCGLHGSYVLRVEAERLTLLAPGAQRQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKIQGKAGQGQDVLRADSHEGEVADGKLASLAAPLELPGSPPALYSEPLDSLRIPPGPSQDSLYSDPLDSTPARAGEGTQLKKALYWDLCEHVQQKLIKAKLTDPKEDPIYDEPEGLAPATLRGLYDLPQEPKDAWWCQARVKEEGYELPYNPAMDDYAVPPPRSTKPFPAPKPQGLALSESGAATGSGSQGHSSDTALYSQVQKSGASGSWDCGLSGVVTDRTGAKSEGST", "length": 514, "header": "tr|F1MRT5-1|F1MRT5_BOVIN Computationally mapped isoform of Docking protein 1 OS=Bos taurus OX=9913 GN=DOK1 PE=3 SV=2 CANONICAL=A0AAA9T1U3-1" }, "locus": { "chromosome": "11", "start_pos": 10088615, "end_pos": 10086124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024727.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024727.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024727.4", "url": "https://www.ensembl.org/id/ENSBTAP00000024727.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 323, "start_aa": "Thr", "end_pos": 323, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8849469", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849469", "resource": "Reactome", "description": "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZ39-1", "protein_name": "Docking protein 1", "gene_name": "DOK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPPAKEGQLFVQHSNKFGTKRWKRGWFALFPASQHGVARLEFFDCKEAAGPAGRLGTRRLDKTVVRLADCTSVTPAPAESGPRAGTAAFRLETSGRSYLLAAEQQQSEEWVAKLCEIAFPGNGPRNAAVAVQCGGEGSGEAPVLEMAVNSIYYSRDEVNAFWVTVQRTEAAERCELRGSYVLKAERDSLILKDPRTREILYVWPYRLLRRYGRDKVMFSFEAGRRCDSGPGNFTFETKQGNEIFRLVEASIREQKAQVEENQQSCDSLESDSPSVVLIRQALADALSLEQPTEGDDAAAPKAGLAPRPSAAAEERDAISLLKTRMLPEPPVLQAKPPITSTPPRSPLPKAPRAVLPDKDPSSLYSEPLDSVKGFRPRLDPLYADPIDSKATGAVDGVKLRVPFPGTCEQVRAEGCGPARKEHIYDEPEGCAPRVLPAATSIYDEARPIGEAWRTQGHDGKSGYEYPYNPSTDDYSVPAFKAKGPKPVPAPKPPATFISKCAERSEDPGRWRGNLAPEKPAIKPGLNSSNNNNNTEVLYCRVVKPQRGQRKEQCVDECSLSPVYEDLGEI", "length": 570 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SNV8-1", "protein_name": "Docking protein 1", "gene_name": "DOK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGPSSGGGRGGSRRLDCKVIRLAECVSVAPVAVESPPEPGAAAFRLDTAQRSHLLAADAPSSVAWVQTLCRNAFPKGSWALAPAENPPKLSALEMLENSLYSPAWEGSQFWVTAQRTEAAERCGLHGSYVLRVEAEKLTLLAVAAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVENAIHRQKAQGKAVQGQDVLRADSHEGEVAEGTLASPPGPQELPGNPPAVYAEPLDSLRVPPRPSRDSLYSDPLDSTPARAGEGAQLKKPLYWDLYEHVQQQLLKTKLTDPKEDPIYDEPEGLAPAALRGLYDLPQEPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRNTKPFPAPKPQGPAFSEARAATGSGSKGHSSDTALYSQVQKSGASGSWDCGLSGVGTDKMGVKSEDST", "length": 483 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I7U7-1", "protein_name": "Docking protein 1 isoform X1", "gene_name": "Dok1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSGGGRGGSRRLDCKMIRLAECVSVAPVSVESPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQSLCRNAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTTQKTEASERCGLQGSYILRVEAEKLTLLTLGTQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGAGTFTFQTTQGNDIFQAVEAAIQKQKAQGKVGQAQDILRTESHEGEAEVKVTSPPAPQEPLDSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPARAGEGMHSKKPLYWDLYGHVQQRLLKAKLTDSKEDPIYDEPEGLAPAPPRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRNSKPVPAPKPQGLVLPEPGTTGGSGSKDHSSDMALYSQVQKSGTSGGWDCGFSRVGNDRTGVKSEGST", "length": 480 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P97465-1", "protein_name": "Docking protein 1", "gene_name": "Dok1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSRGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGAVAFRLDTAQRSHLLAADAVSSTAWVQTLCRTAFPKGGWALAQTENQPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKAQGKVGQAQDILRTDSHDGETEGKTVPPPVPQDPLGSPPALYAEPLDSLRIPPGPSQDSVYSDPLGSTPAGAGEGVHSKKPLYWDLYGHVQQQLLKTKLTDSKEDPIYDEPEGLAPAPPRGLYDLPQEPRDAWWCQARLKEEGYELPYNPATDDYAVPPPRSPKPAPAPKPQGLILPESGTTRGSGSKGFSSDTALYSQVQKSGTSGAWDCGLSKVGNDRAGVKSEGST", "length": 482 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4QQV2-1", "protein_name": "Docking protein 1", "gene_name": "Dok1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDGALMEGPLFLQSQRFGTKRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAADAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKPLYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQVQKSGTPGRWDCGLSRVGNDRVGVKSEGST", "length": 480 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99704-1", "protein_name": "Docking protein 1", "gene_name": "DOK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST", "length": 481 }, "evidence": [ { "id": "A0AAA9T1U3", "url": "https://omabrowser.org/oma/group/A0AAA9T1U3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T1U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1U3" }, { "id": "PS51064", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51064" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IRS-type PTB", "eco_id": "ECO_0000259", "start_pos": 152, "end_pos": 260, "start_aa": "Glu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": 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"id": "A0AAA9T2L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVRKPKHEKL", "length": 294, "header": "tr|A0AAA9T2L1-1|A0AAA9T2L1_BOVIN Isoform 1 of Alpha/beta hydrolase domain-containing protein 17B OS=Bos taurus OX=9913 GN=ABHD17B PE=3 SV=1 CANONICAL=A0AAA9T2L1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1/entry#A0AAA9SKP7-1", "sequence": { "sequence": "MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELLSKNYAAVQ", "length": 294, "header": "tr|A0AAA9SKP7-1|A0AAA9T2L1_BOVIN Computationally mapped isoform of Alpha/beta hydrolase domain-containing protein 17B OS=Bos taurus OX=9913 GN=ABHD17B PE=3 SV=1 CANONICAL=A0AAA9T2L1-1" }, "locus": { "chromosome": "8", "start_pos": 48117102, "end_pos": 48101086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134555.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134555.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083198.1" } ] } }, { "isoform_ac": "A0AAA9T2L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1/entry#A0AAA9T2L1-1", "sequence": { "sequence": "MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVRKPKHEKL", "length": 294, "header": "tr|A0AAA9T2L1-1|A0AAA9T2L1_BOVIN Isoform 1 of Alpha/beta hydrolase domain-containing protein 17B OS=Bos taurus OX=9913 GN=ABHD17B PE=3 SV=1 CANONICAL=A0AAA9T2L1-1" }, "locus": { "chromosome": "8", "start_pos": 48117102, "end_pos": 48106502, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090874.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of protein localization to endosome", "id": "GO:1905668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905668", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" }, { "name": "regulation of protein localization to synapse", "id": "GO:1902473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902473", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" }, { "name": "regulation of dendritic spine maintenance", "id": "GO:1902950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902950", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" }, { "name": "negative regulation of protein localization to microtubule", "id": "GO:1902817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19233", "name": "", "equation": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T2L1-1", "A0AAA9SCF5-1", "A0AAA9SFH2-1", "A0A3Q1M5Z8-1", "G3MWX2-1", "A0AAF6YMI2-1", "A5PKD9-1", "P45478-1", "Q3MHR0-1", "Q1ZYR0-1", "Q5E9H9-1", "F1MNH5-1", "Q2HJ19-1", "A0AAA9S0E0-1", "F1MYM8-1", "F6RC73-1", "F1N587-1" ], "evidence": [ { "id": "19233", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19233" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M5Z8", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] } ] }, { "uniprot_ac": "A0AAA9S0E0", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] } ] }, { "uniprot_ac": "A0AAA9SCF5", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SCF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF5" } ] } ] }, { "uniprot_ac": "A0AAA9SFH2", "gene_name": "DESI1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9SFH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFH2" } ] } ] }, { "uniprot_ac": "A0AAA9T2L1", "gene_name": "ABHD17B", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" } ] } ] }, { "uniprot_ac": "A0AAF6YMI2", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.1.93", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAF6YMI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMI2" } ] } ] }, { "uniprot_ac": "A5PKD9", "gene_name": "ABHD17C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A5PKD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKD9" } ] } ] }, { "uniprot_ac": "F1MNH5", "gene_name": "DESI2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MNH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNH5" } ] } ] }, { "uniprot_ac": "F1MYM8", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1MYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM8" } ] } ] }, { "uniprot_ac": "F1N587", "gene_name": "CPT1C", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1N587", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N587" } ] } ] }, { "uniprot_ac": "F6RC73", "gene_name": "LYPLAL1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F6RC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RC73" } ] } ] }, { "uniprot_ac": "G3MWX2", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "G3MWX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWX2" } ] } ] }, { "uniprot_ac": "P45478", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P45478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P45478" } ] } ] }, { "uniprot_ac": "Q1ZYR0", "gene_name": "CLN5", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q1ZYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1ZYR0" } ] } ] }, { "uniprot_ac": "Q2HJ19", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q2HJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ19" } ] } ] }, { "uniprot_ac": "Q3MHR0", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q3MHR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHR0" } ] } ] }, { "uniprot_ac": "Q5E9H9", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.1.93", "activity": "mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+).", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5E9H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9H9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L1" }, { "id": "PF12146", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12146" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Serine aminopeptidase S33", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 196, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.22", "ec_name": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "3.1.2.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22" }, { "id": "3.1.2.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T4Q9-1", "uniprot_ac": "A0AAA9T4Q9", "uniprot_id": "A0AAA9T4Q9_BOVIN", "mass": { "chemical_mass": 175325.0, "monoisotopic_mass": 175325.0 }, "refseq": { "ac": "XP_059735134", "name": "bromodomain adjacent to zinc finger domain protein 1A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735134" }, "gene_names": [ { "name": "BAZ1A", "type": "recommended", "evidence": [ { "id": "A0AAA9T4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ] }, { "name": "BAZ1A", "type": "synonym", "evidence": [ { "id": "XP_059735134", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735134" } ] } ], "protein_names": [ { "name": "Bromodomain adjacent to zinc finger domain protein 1A", "type": "recommended", "evidence": [ { "id": "A0AAA9T4Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9/entry#names_and_taxonomy" } ] }, { "name": "bromodomain adjacent to zinc finger domain protein 1A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059735134", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735134" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BAZ1A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9", "locus": { "chromosome": "21", "start_pos": 45116282, "end_pos": 45202931, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020164", "url": "https://www.ensembl.org/id/ENSBTAG00000020164" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05504", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05504", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15627", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15627", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540621", "url": "https://www.ncbi.nlm.nih.gov/gene/540621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047171", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047171", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BN25", "url": "https://www.orthodb.org/?gene=E1BN25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46510", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46510", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46510:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46510:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02791", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02791", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10537", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10537", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059735134", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735134", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN25", "url": "https://www.uniprot.org/uniprotkb/E1BN25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN25-1", "url": "https://www.uniprot.org/uniprotkb/E1BN25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESERKARQNLQSFPEPLIVPVLYLTNLTHRSRLHEICDDIFAYIKDRYFVEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVSSVDGETIVISDSDDSETQNSSFQNGKKKDAIDPLLFKYKVQPTKKELYECAIVKATQISRRKHLFSRDKLKLFLKQHCEPQDGVIKIKASSLSTYKIAEQDFSYFFPDDPPTFIFSPANRRRGRPPKRISVSQEDSIASKQTIAGYRNKTTKERDKLLKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKEKKKEELKKIVEKERLKKKEEKERLKIEREKEREKLREEKKKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEIFGDALMVLEFLNAFGELFDLQDEFPEGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQITDADTKGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSIADISVGEEEREDFDTSTESKEIEQKEQDQDTVSEDEDDPGPHKRGRRGKRGQNGFKEFTRQEEVNCITREPLTAEEEEALKQEHQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFQDNVQSQAPQVSTKTGDSLMSESTSSIDHGPYDDTVQLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHRESALKETLLQEKSRICAQLSRFSEEKFHFSDKPQTDSKPTYSRGRSSSVYDPSQMSAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHLWRSALENGQYELLNEENKENGIIKTVNEDAEEMEIDEQAKVIVKDRLLGIKTESPSTVSTNASTPQSVSNVVHHLAMALFQIEQGIERRFLKAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRLSSRQRPSLESDDEMEGSMEGEDDEVDDDEEEGQSEEEEYEVEQDEDDSQEEEEVSPPKRGRPQVRLPIKTRGRLSSSFSSRGQRQDPGRYTSRSQQSTPKTTASSKTTGRSLRKIKSAPPTETKSLRIASRSTRQSHGALQADVFVELLSPRRKRRGRKSANNTPENSPSFPNFRVIAAKSSEQSSPLNVASKLSLQDSESKRRGRKRQSAESSPMTLNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTSGNVDQVSTPPAAKKSRI", "length": 1525, "header": "tr|A0AAA9T4Q9-1|A0AAA9T4Q9_BOVIN Isoform 1 of Bromodomain adjacent to zinc finger domain protein 1A OS=Bos taurus OX=9913 GN=BAZ1A PE=3 SV=1 CANONICAL=A0AAA9T4Q9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9/entry#A0AAA9T4Q9-1", "sequence": { "sequence": "MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESERKARQNLQSFPEPLIVPVLYLTNLTHRSRLHEICDDIFAYIKDRYFVEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVSSVDGETIVISDSDDSETQNSSFQNGKKKDAIDPLLFKYKVQPTKKELYECAIVKATQISRRKHLFSRDKLKLFLKQHCEPQDGVIKIKASSLSTYKIAEQDFSYFFPDDPPTFIFSPANRRRGRPPKRISVSQEDSIASKQTIAGYRNKTTKERDKLLKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKEKKKEELKKIVEKERLKKKEEKERLKIEREKEREKLREEKKKYMEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEIFGDALMVLEFLNAFGELFDLQDEFPEGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQITDADTKGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSIADISVGEEEREDFDTSTESKEIEQKEQDQDTVSEDEDDPGPHKRGRRGKRGQNGFKEFTRQEEVNCITREPLTAEEEEALKQEHQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFQDNVQSQAPQVSTKTGDSLMSESTSSIDHGPYDDTVQLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHRESALKETLLQEKSRICAQLSRFSEEKFHFSDKPQTDSKPTYSRGRSSSVYDPSQMSAERQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHLWRSALENGQYELLNEENKENGIIKTVNEDAEEMEIDEQAKVIVKDRLLGIKTESPSTVSTNASTPQSVSNVVHHLAMALFQIEQGIERRFLKAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRLSSRQRPSLESDDEMEGSMEGEDDEVDDDEEEGQSEEEEYEVEQDEDDSQEEEEVSPPKRGRPQVRLPIKTRGRLSSSFSSRGQRQDPGRYTSRSQQSTPKTTASSKTTGRSLRKIKSAPPTETKSLRIASRSTRQSHGALQADVFVELLSPRRKRRGRKSANNTPENSPSFPNFRVIAAKSSEQSSPLNVASKLSLQDSESKRRGRKRQSAESSPMTLNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTSGNVDQVSTPPAAKKSRI", "length": 1525, "header": "tr|A0AAA9T4Q9-1|A0AAA9T4Q9_BOVIN Isoform 1 of Bromodomain adjacent to zinc finger domain protein 1A OS=Bos taurus OX=9913 GN=BAZ1A PE=3 SV=1 CANONICAL=A0AAA9T4Q9-1" }, "locus": { "chromosome": "21", "start_pos": 45202855, "end_pos": 45116772, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118577.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118577.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092795.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092795.1" } ] } }, { "isoform_ac": "E1BN25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9/entry#E1BN25-1", "sequence": { "sequence": 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"length": 1562, "header": "tr|E1BN25-1|E1BN25_BOVIN Computationally mapped isoform of Bromodomain adjacent to zinc finger domain protein 1A OS=Bos taurus OX=9913 GN=BAZ1A PE=3 SV=4 CANONICAL=A0AAA9T4Q9-1" }, "locus": { "chromosome": "21", "start_pos": 45202855, "end_pos": 45116772, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026857.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026857.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026857.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026857.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 414, "start_aa": "Thr", "end_pos": 414, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr414", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "nuclear chromosome", "id": "GO:0000228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "CHRAC", "id": "GO:0008623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4Q9" } ], "pmid": "" }, { "name": "regulation of heterochromatin formation", "id": "GO:0031445", "url": 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"chromosome": "8", "start_pos": 88754736, "end_pos": 88789458, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001939", "url": "https://www.ensembl.org/id/ENSBTAG00000001939" } ] } } ], "crossref": [ { "id": "A0AAA9T5W9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5W9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511202", "url": "https://www.ncbi.nlm.nih.gov/gene/511202", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511202", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511202", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVFPSCA", "url": "https://omabrowser.org/oma/group/CVFPSCA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MK37", "url": "https://www.orthodb.org/?gene=A0A3Q1MK37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N285", "url": "https://www.orthodb.org/?gene=A0A3Q1N285", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BMA4", "url": "https://www.orthodb.org/?gene=E1BMA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13284", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13284", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13284:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13284:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N285", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N285", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N285-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N285-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMA4", "url": "https://www.uniprot.org/uniprotkb/E1BMA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMA4-1", "url": "https://www.uniprot.org/uniprotkb/E1BMA4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEGRREPAAEGIKLSADVKPFVPKFAGLNVGWSESSEARVFPSCAATPYYPCVQELAVPEQKLYTDDMAFGASAFPSQYFSAEIPLHPYAYSPYTLQSPQNVCPVPGSPYDDNQPSCFGGFQRLKPRSEHTCPLSQDTKAVFKKKTYDEQKFDSKKTDGPVSSDLKSVKDSPRVSIHAENSLKSDGYYKRTDRKSRIIEKSGSASKPEFGFTRLDFPELQSPENSEIPKIQKQPKWGPLRSTSTDISLLREMGTPSAVLSEGEIVVKNNNRTESVTDNAVTSPSSCTRELSWTPMGYVVRQTLSTELSPAPKNVTSMINLKMVASPADPKNDSMSSSEVLSLEPSYKEKHVVHLTEKSKASQGGNPEQNEASRKNKKKKEKSKSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRVESPKFQSKQQPQNNFKSSRKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSMSGKKGHRLAQVKTPHNPLDSTSPMMKKGKQREVPKAKKPTPLKKIILKERQERKQQRLQENALSPAFPSDDVQDVQDEESGGDDQVLRPPDMLGETKESVSCVPVVESKSEEQPGAEPQKETEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKAKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACDQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLENARQELPGELGPCAPVGPPSQGPGCPVEDSPLAPTEKEEPHYIQVWRNHVEAYSRCGLELEESLEASTSQMMNLNL", "length": 844, "header": "tr|A0AAA9T5W9-1|A0AAA9T5W9_BOVIN Isoform 1 of SECIS binding protein 2 OS=Bos taurus OX=9913 GN=SECISBP2 PE=4 SV=1 CANONICAL=A0AAA9T5W9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MK37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9/entry#A0A3Q1MK37-1", "sequence": { "sequence": "MASEGRREPAAEGIKLSADVKPFVPKFAGLNVGWSESSEARVFPSCAATPYYPCVQELAVPEQKLYTDDMAFGASAFPSQYFSAEIPLHPYAYSPYTLQSPQNVCPVPGSPYDDNQPSCFGGFQRLKPRSEHTCPLSQDTKAVFKKKTYDEQKFDSKKTDGPVSSDLKSVKDSPRVSIHAENSLKSDGYYKRTDRKSRIIEKSGSASKPEFGFTRLDFPELQSPENSEIPKIQKQPKWGPLRSTSTDISLLREMGTPSAVLSETLSTELSPAPKNVTSMINLKMVASPADPKNDSMSSSEVLSLEPSYKEKHVVHLTEKSKASQGGNPEQNEASRKNKKKKEKSKSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRVESPKFQSKQQPQNNFKSSRKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSMSGKKGHRLAQVKTPHNPLDSTSPMMKKGKQREVPKAKKPTPLKKIILKERQERKQQRLQENALSPAFPSDDVQDVQDEESGGDDQVLRPPDMLGETKESVSCVPVVESKSEEQPGAEPQKETEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKAKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACDQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLENARQELPGELGPCAPVGPPSQGPGCPVEDSPLAPTEKEEPHYIQVWRNHVEAYSRCGLELEESLEASTSQMMNLNL", "length": 804, "header": "tr|A0A3Q1MK37-1|A0AAA9T5W9_BOVIN Computationally mapped isoform of SECIS binding protein 2 OS=Bos taurus OX=9913 GN=SECISBP2 PE=4 SV=1 CANONICAL=A0AAA9T5W9-1" }, "locus": { "chromosome": "8", "start_pos": 88789259, "end_pos": 88755740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070951.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070951.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071819.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071819.1" } ] } }, { "isoform_ac": "A0A3Q1N285-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9/entry#A0A3Q1N285-1", "sequence": { "sequence": "MASEGRREPAAEGIKLSADVKPFVPKFAGLNVGWSESSEARVFPSCAATPYYPCVQELAVPEQKLYTDDMAFGASAFPSQYFSAEIPLHPYAYSPYTLQSPQNVCPVPGSPYDDNQPSCFGGFQRLKPRSEHTCPLSQDTKAVFKKKTYDEQKFDSKKTDGPVSSDLKSVKDSPRVSIHAENSLKSDGYYKRTDRKSRIIEKSGSASKPEFGFTRLDFPELQSPENSEIPKIQKQPKWGPLRSTSTDISLLREMGTPSAVLSEGEIVVKNNNRTESVTDNAVTSPSSCTRELSWTPMGYVVRQTLSTELSPAPKNVTSMINLKMVASPADPKNDSMSSSEVLSLEPSYKEKHVVHLTEKSKASQGGNPEQNEASRKNKKKKEKSKSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRVESPKFQSKQQPQNNFKSSRKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSMSGKKGHRLAQVKTPHNPLDSTSPMMKKGKQREVPKAKKPTPLKKIILKERQERKQQRLQENALSPAFPSDDVQDVQDEESGGDDQVLRPPDMLGETKESVSCVPVVESKSEEQPGAEPQKETEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKAKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKASRGPWAAAVPAHGQPHGLIPILAGGRSRPCRWKGLSGGLDDTLHTIIDYACDQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLENARQELPGELGPCAPVGPPSQGPGCPVEDSPLAPTEKEEPHYIQVWRNHVEAYSRCGLELEESLEASTSQMMNLNL", "length": 881, "header": "tr|A0A3Q1N285-1|A0AAA9T5W9_BOVIN Computationally mapped isoform of SECIS binding protein 2 OS=Bos taurus OX=9913 GN=SECISBP2 PE=4 SV=2 CANONICAL=A0AAA9T5W9-1" }, "locus": { "chromosome": "8", "start_pos": 88789259, "end_pos": 88755740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071393.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071393.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063334.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063334.2" } ] } }, { "isoform_ac": "A0AAA9T5W9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9/entry#A0AAA9T5W9-1", "sequence": { "sequence": "MASEGRREPAAEGIKLSADVKPFVPKFAGLNVGWSESSEARVFPSCAATPYYPCVQELAVPEQKLYTDDMAFGASAFPSQYFSAEIPLHPYAYSPYTLQSPQNVCPVPGSPYDDNQPSCFGGFQRLKPRSEHTCPLSQDTKAVFKKKTYDEQKFDSKKTDGPVSSDLKSVKDSPRVSIHAENSLKSDGYYKRTDRKSRIIEKSGSASKPEFGFTRLDFPELQSPENSEIPKIQKQPKWGPLRSTSTDISLLREMGTPSAVLSEGEIVVKNNNRTESVTDNAVTSPSSCTRELSWTPMGYVVRQTLSTELSPAPKNVTSMINLKMVASPADPKNDSMSSSEVLSLEPSYKEKHVVHLTEKSKASQGGNPEQNEASRKNKKKKEKSKSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRVESPKFQSKQQPQNNFKSSRKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSMSGKKGHRLAQVKTPHNPLDSTSPMMKKGKQREVPKAKKPTPLKKIILKERQERKQQRLQENALSPAFPSDDVQDVQDEESGGDDQVLRPPDMLGETKESVSCVPVVESKSEEQPGAEPQKETEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKAKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACDQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLENARQELPGELGPCAPVGPPSQGPGCPVEDSPLAPTEKEEPHYIQVWRNHVEAYSRCGLELEESLEASTSQMMNLNL", "length": 844, "header": "tr|A0AAA9T5W9-1|A0AAA9T5W9_BOVIN Isoform 1 of SECIS binding protein 2 OS=Bos taurus OX=9913 GN=SECISBP2 PE=4 SV=1 CANONICAL=A0AAA9T5W9-1" }, "locus": { "chromosome": "8", "start_pos": 88789259, "end_pos": 88755740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124744.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124744.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094156.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094156.1" } ] } }, { "isoform_ac": "E1BMA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9/entry#E1BMA4-1", "sequence": { "sequence": "MASEGRREPAAEGIKLSADVKPFVPKFAGLNVGWSESSEARVFPSCAATPYYPCVQELAVPEQKLYTDDMAFGASAFPSQYFSAEIPLHPYAYSPYTLQSPQNVCPVPGSPYDDNQPSCFGGFQRLKPRSEHTCPLSQDTKAVFKKKTYDEQKFDSKKTDGPVSSDLKSVKDSPRVSIHAENSLKSDGYYKRTDRKSRIIEKSGSASKPEFGFTRLDFPELQSPENSEIPKIQKQPKWGPLRSTSTDISLLREMGTPSAVLSEGEIVVKNNNRTESVTDNAVTSPSSCTRELSWTPMGYVVRQTLSTELSPAPKNVTSMINLKMVASPADPKNDSMSSSEVLSLEPSYKEKHVVHLTEKSKASQGGNPEQNEASRKNKKKKEKSKSKYEVLTVQEPPRIENNFKSSRKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSMSGKKGHRLAQVKTPHNPLDSTSPMMKKGKQREVPKAKKPTPLKKIILKERQERKQQRLQENALSPAFPSDDVQDVQDEESGGDDQVLRPPDMLGETKESVSCVPVVESKSEEQPGAEPQKETEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKAKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACDQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLENARQELPGELGPCAPVGPPSQGPGCPVEDSPLAPTEKEEPHYIQVWRNHVEAYSRCGLELEESLEASTSQMMNLNL", "length": 814, "header": "tr|E1BMA4-1|A0AAA9T5W9_BOVIN Computationally mapped isoform of SECIS binding protein 2 OS=Bos taurus OX=9913 GN=SECISBP2 PE=4 SV=3 CANONICAL=A0AAA9T5W9-1" }, "locus": { "chromosome": "8", "start_pos": 88789259, "end_pos": 88755740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002523.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002523.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002523.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002523.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511202", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511202", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061ICJ0-1", "protein_name": "Selenocysteine insertion sequence-binding protein 2 isoform X1", "gene_name": "Secisbp2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASERPREPEGEDSIKLSADVKPFVPKFGGLNVEWSESSEARVFPGCPANYYPFVQESPVTEQKVYPEDMAFGAPAFPRQYVSSEITLHPFACSTYALDSAQSVCSVPALQCDHSQPHCHLGCRTEKPQNEHTCPLPREAKGVFKKRPSDERRTGDEQRSSSRRADGAVPSEMRAARGSYHLSARTESGLKTDGHHRRADRKSRVLTKSVCTSKPEFEFSRLDFPELQSSKTSNVQETQKQPRWGPLGSAARNASLLRDAGKPSAGMVAGEMVKTNHTGGAVTHRAANSSPSCTRAELSWTPMGYIVRQTVSSGSAAATENVSSVITLKKTASSTDPQSAGVAPEAVSSDSSYNRETSVHSATKAKASQGGELEQNETSRKNKKKKEKSKPNYEVLTVQEPPRIEDAEEFPNLSAASERRHRVESPKLQRKQQMQSDFKAGGKKSQTPVQLDLGGMLAALEKQQQVPHAKPSSRPVVFSVGAVPVLSKDASSGERGRRSSQVKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQLRLQESAVSLAVANGDAQDVESSASDHVPQQVHPTGPEKTEESVSSTPVIEGESEEPTGTEFQKNPAACQPAPGSATFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETVRQELAGQPGPQTPPSPPIQDPIQSTEEGTLESTGKEPHYIEIWRKHLEAYSQQALELEDSLEASTSQMMNLNL", "length": 856 }, "evidence": [ { "id": "A0AAA9T5W9", "url": "https://omabrowser.org/oma/group/A0AAA9T5W9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A287BMS4-1", "protein_name": "SECIS binding protein 2", "gene_name": "SECISBP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASEGPREPAGEGIKLSADVKPFVPKFAGLSVAWSESSETRVFPSCAATTYYPCVQELAVPEQKLYTEGMAFGASTFPPQYLSSEITLHPYAYPPYTLESSQNVCPAPGSQYDYNQPTCFGGFQTVKPRNEHIVKPRNEHMYPLPQDMKALFKKKTYDEQRFDSKKTDGPISSDLKSVKGSHPMSIHAESSLKSDGYYKRTERKSRIIEKSGSASKPEFEFTRLDFPELQGPESREIPEIQKQPKWGPLRSASTDVSLLREAGKPAVALPEGEIVVKNNNPTESVTDNAAANPSSCTRELSWTPMGYVVRQTLSTELSPAPKNVTSMINLKMIASSADPKNGSMSSSEVLSSDPCFKEKHVVHPTKKSKASQCCHPEQNEVSRKNKKKKEKSKSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRVESPKFQSKQQPQNNFKSSGKKSQIPVQLDLGGMLTALEKKQHSPNAKQSSKPVVFSVGAVPVLSKDSVSGKKGHRFGQVKTPHNPLDSSAPLMKKGKQREVPKAKKPTSLKKIILKERQERKQQRLQENAVSPAFAGDDLQDGERGGDDQALEQLDPSGETEESVSCASVENKSEEWLGAELQKEAEACPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACEQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTMAARQAYRTMLEKARQELAAEPGAQGAASPPAQGPSGPEEDGPPGPAGKEEPHYIEIWRNHLEAYSRCAQELEESLEVSTSQMMNLNL", "length": 848 }, "evidence": [ { "id": "A0AAA9T5W9", "url": "https://omabrowser.org/oma/group/A0AAA9T5W9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U1C4-1", "protein_name": "Selenocysteine insertion sequence-binding protein 2", "gene_name": "Secisbp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASERPREPDGEDSIKLSADVKPFVPKFAGLNVAWSESSETRVFPGCAATYYPFVQEPPAAEQKMYPEDMAFGAPTFPAQYVSSEIALHPFAYPTYTLESAQSVCSVPTLQYDYSQARCHPGFRTAKPRHEHVCPPPQEAKGVFKKKPSDERRACEEQKSSSRRADNAVPCEARPARGSSHLSSRTESSLKSDGYHKRPDRKSRILAKSASTSKPEFEFSRLDFPELQSPKNSNMPETQKPPRWGPLGPAASNMPLLGDVGKPVADMVEGKMVKSDHTDGAVTSNATTSSPSCTQELSWTPMGYIVRQTVSSDSAAATENVTSMINLKKTTSSADAKNVSVTSEALSSNPSYNREKRVYPAPKAKASQGGELEQNESSKKNKKKKEKSKPSYEVLTVQEPPRIEDAEEFPNLSVASERRHRGQSPKLHSKQQTQNEFKTSGKKSQVPVQLDLGGMLAALEKQQQQQHASHAKPSSRPVVFSVGAVPVLSKDASSSERGRRSSQMKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSLTVASDDSQDVESGASNQTPSQDNPTGPEKTEESVSSTPVVEGESEEPAGTEFQRDPEACQPAPDSATFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQSPPSPPMQDPIPSTEEGTLPSTGEEPHYIEIWKKHLEAYSQRALELEDSLEASTSQMMNLNL", "length": 858 }, "evidence": [ { "id": "A0AAA9T5W9", "url": "https://omabrowser.org/oma/group/A0AAA9T5W9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96T21-1", "protein_name": "Selenocysteine insertion sequence-binding protein 2", "gene_name": "SECISBP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSVGAVPVLSKECASGERGRRMSQMKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERKQRLQENAVSPAFTSDDTQDGESGGDDQFPEQAELSGPEGMDELISTPSVEDKSEEPPGTELQRDTEASHLAPNHTTFPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLKKLKCVIISPNCEKIQSKGGLDDTLHTIIDYACEQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTVAARQAYKTMLENVQQELVGEPRPQAPPSLPTQGPSCPAEDGPPALKEKEEPHYIEIWKKHLEAYSGCTLELEESLEASTSQMMNLNL", "length": 854 }, "evidence": [ { "id": "A0AAA9T5W9", "url": "https://omabrowser.org/oma/group/A0AAA9T5W9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QX72-1", "protein_name": "Selenocysteine insertion sequence-binding protein 2", "gene_name": "Secisbp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASERPREPEGEDSIKLSADVKPFVPKFAGLNVAWSESSEACVFPGCAATYYPFVQESPAAEQKMYPEDMAFGAPAFPAQYVSSEIALHPFAYPTYALESTQSVCSVPTLQYDYSQAQCHPGFRPAKPRNEHACPPQEAKCVFKKKSSDERRAWEEQKSSNRRADGAVPCEARPARGSCHLKSDGYHKRPDRKSRILTKSASTSKPEFEFSRLDFPELQSPKNSNLPETQKQPRWGPLGPAASNMSLLGEAGKPVADMVEGKMVKTDHTDGAVTNNAATSSPSCTRELSWTPMGYIVRQTVSSDSAAATETVNSIINLKKTTSSADAKNVSVTSEALSSDPSFSREKRVHPGPKAKASQGSELEQNESSKKNKKKKEKSKSSYEVLPVQEPPRIEDAEEFPNLSVASERRHRGESPKLQSKQQAQNDFKTGGKKSQVPVQLDLGGMLAALEKQQHAPHAKPSSRPVVFSVGAVPVLSKDASSGERGRRSSQVKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSPTVASDDSQDVESGVTNQIPSPDNPTGPEKTEEPMSSTPVVEGESEEPAGTEFQRDPEACQPAPDSATFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQTPPSPPMQDPIQSTDEGTLASTGEEPHYIEIWRKHLEAYSQHALELEDSLEASTSQMMNLNL", "length": 846 }, "evidence": [ { "id": "A0AAA9T5W9", "url": "https://omabrowser.org/oma/group/A0AAA9T5W9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "selenocysteine incorporation", "id": "GO:0001514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "selenocysteine insertion sequence binding", "id": "GO:0035368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035368", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex binding", "id": "GO:0043021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5W9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5W9" }, { "id": "PF01248", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01248" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ribosomal protein eL8/eL30/eS12/Gadd45", "eco_id": "ECO_0000259", "start_pos": 651, "end_pos": 747, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 272, "end_pos": 274 }, { "start_pos": 315, "end_pos": 317 }, { "start_pos": 333, "end_pos": 335 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9B0-1", "uniprot_ac": "A0AAA9T9B0", "uniprot_id": "A0AAA9T9B0_BOVIN", "mass": { "chemical_mass": 106992.0, "monoisotopic_mass": 106992.0 }, "refseq": { "ac": "XP_005217563", "name": "mineralocorticoid receptor isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217563" }, "gene_names": [ { "name": "NR3C2", "type": "recommended", "evidence": [ { "id": "A0AAA9T9B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ] }, { "name": "NR3C2", "type": "synonym", "evidence": [ { "id": "XP_005217563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217563" } ] } ], "protein_names": [ { "name": "Mineralocorticoid receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T9B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor subfamily 3 group C member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T9B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#names_and_taxonomy" } ] }, { "name": "mineralocorticoid receptor isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005217563", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217563" } ] } ], "function": [ { "annotation": "Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0#function" }, { "database": "UniProtKB", "id": "ARBA00037128", "url": "https://www.uniprot.org/uniprotkb/ARBA00037128#function" }, { "database": "UniProtKB", "id": "A0AAA9TW20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW20#function" }, { "database": "UniProtKB", "id": "F1MKV9", "url": "https://www.uniprot.org/uniprotkb/F1MKV9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR3C2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0", "locus": { "chromosome": "17", "start_pos": 10019759, "end_pos": 9583621, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027182", "url": "https://www.ensembl.org/id/ENSBTAG00000027182" } ] } } ], "crossref": [ { "id": "A0AAA9T9B0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9B0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027182", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027182", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07075", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07075", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07172", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07172", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537614", "url": "https://www.ncbi.nlm.nih.gov/gene/537614", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ITFPKME", "url": "https://omabrowser.org/oma/group/ITFPKME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N5N2", "url": "https://www.orthodb.org/?gene=A0A3Q1N5N2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MKV9", "url": "https://www.orthodb.org/?gene=F1MKV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3371497", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4090294", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4090294", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217563", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217563", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5N2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5N2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5N2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKV9", "url": "https://www.uniprot.org/uniprotkb/F1MKV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKV9-1", "url": "https://www.uniprot.org/uniprotkb/F1MKV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSWQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQAQQPPAPPPPPQSPEEGTTYIAPAQEPSVNSALVPQLSTISRALTPSPSMILETIEPEIVYAGYDGSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKTLYFHRK", "length": 988, "header": "tr|A0AAA9T9B0-1|A0AAA9T9B0_BOVIN Isoform 1 of Mineralocorticoid receptor OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=1 CANONICAL=A0AAA9T9B0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N5N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#A0A3Q1N5N2-1", "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSWQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQAQQPPAPPPPPQSPEEGTTYIAPAQEPSVNSALVPQLSTISRALTPSPSMILETIEPEIVYAGYDGSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDMLPDSLTR", "length": 945, "header": "tr|A0A3Q1N5N2-1|A0AAA9T9B0_BOVIN Computationally mapped isoform of Mineralocorticoid receptor OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=2 CANONICAL=A0AAA9T9B0-1" }, "locus": { "chromosome": "17", "start_pos": 9987358, "end_pos": 9589542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070997.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070997.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065532.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065532.2" } ] } }, { "isoform_ac": "A0AAA9T9B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#A0AAA9T9B0-1", "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSWQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQAQQPPAPPPPPQSPEEGTTYIAPAQEPSVNSALVPQLSTISRALTPSPSMILETIEPEIVYAGYDGSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKTLYFHRK", "length": 988, "header": "tr|A0AAA9T9B0-1|A0AAA9T9B0_BOVIN Isoform 1 of Mineralocorticoid receptor OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=1 CANONICAL=A0AAA9T9B0-1" }, "locus": { "chromosome": "17", "start_pos": 10018755, "end_pos": 9589542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112526.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112526.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092488.1" } ] } }, { "isoform_ac": "A0AAA9TW20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#A0AAA9TW20-1", "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSRTTVQQNINTKIETNPKFQVLQSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQAQQPPAPPPPPQSPEEGTTYIAPAQEPSVNSALVPQLSTISRALTPSPSMILETIEPEIVYAGYDGSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKTLYFHRK", "length": 1006, "header": "tr|A0AAA9TW20-1|A0AAA9TW20_BOVIN Computationally mapped isoform of Mineralocorticoid receptor OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=1 CANONICAL=A0AAA9T9B0-1" }, "locus": { "chromosome": "17", "start_pos": 10018755, "end_pos": 9589542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125862.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125862.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101624.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101624.1" } ] } }, { "isoform_ac": "A0AAA9TYQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#A0AAA9TYQ2-1", "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKTLYFHRK", "length": 869, "header": "tr|A0AAA9TYQ2-1|A0AAA9TYQ2_BOVIN Computationally mapped isoform of Nuclear receptor subfamily 3 group C member 2 OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=1 CANONICAL=A0AAA9T9B0-1" }, "locus": { "chromosome": "17", "start_pos": 10018755, "end_pos": 9589542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094076.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094076.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102628.1" } ] } }, { "isoform_ac": "F1MKV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0/entry#F1MKV9-1", "sequence": { "sequence": "METKGYHSLPEGLEMERRWGQLSQPAERPALGPVPTEQSDESNYMEIVDVRCVSGAIPNSSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVREADYAYDQQNPQGSGSPAKMYQNVEQLVKFYKENGHRPSTLGGASRPLRSFLPDSGGSVNGGVMRNVVKSPILGHEKGPAVCSPLTLSSSGCSPASISCVSSTSASFGSFPVHSPIAQGTPLPCSPNVETRGSRSHSPAHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVTLRSCVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPGSTAFSYTASGTPVGSSAARDVVPSPDTQEKGAQEVPFPKTEETENAISHGVAGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSPFSVPIKQESTKHSCSGTSFKGNPAINPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPMGIKQEPDDGSFYPEASIPPSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHSDLSSRRSDGYPVLEYIPENVSSYGEDKPENSTPLVRCSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQAQQPPAPPPPPQSPEEGTTYIAPAQEPSVNSALVPQLSTISRALTPSPSMILETIEPEIVYAGYDGSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQYLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTVMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPSNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKTLYFHRK", "length": 999, "header": "tr|F1MKV9-1|F1MKV9_BOVIN Computationally mapped isoform of Mineralocorticoid receptor OS=Bos taurus OX=9913 GN=NR3C2 PE=3 SV=3 CANONICAL=A0AAA9T9B0-1" }, "locus": { "chromosome": "17", "start_pos": 10018755, "end_pos": 9589542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003291.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003291.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003291.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003291.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" }, { "id": "R-BTA-4090294", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4090294", "resource": "Reactome", "description": "SUMOylation of intracellular receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P08235-1", "protein_name": "Mineralocorticoid receptor", "gene_name": "NR3C2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK", "length": 984 }, "evidence": [ { "id": "A0AAA9T9B0", "url": "https://omabrowser.org/oma/group/A0AAA9T9B0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P22199-1", "protein_name": "Mineralocorticoid receptor", "gene_name": "Nr3c2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK", "length": 981 }, "evidence": [ { "id": "A0AAA9T9B0", "url": "https://omabrowser.org/oma/group/A0AAA9T9B0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VII8-1", "protein_name": "Mineralocorticoid receptor", "gene_name": "Nr3c2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTNENSYMEIVNVSCVSGATPNNSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPAKIYQNMEQLVKFYKENGHRSSTLSAISRPLRSFMPDSGTSMNGGALRAIVKSPIICHEKSPSVCSPLNMPSSVCSPAGINSMSSSTASFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPVHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNTNNRSTLSSPTASTVGSIGSPISNAFSYTTSGASAGAGAIQDMVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNNKINPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDSSCEGSAFPGGIKQEPDDGSYFPETSIPSSAIIGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNALVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLASITRALTPSPSMILENIEPEIVYAGYDNSKPDTAESLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVNDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK", "length": 978 }, "evidence": [ { "id": "A0AAA9T9B0", "url": "https://omabrowser.org/oma/group/A0AAA9T9B0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "steroid binding", "id": "GO:0005496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "TBP-class protein binding", "id": "GO:0017025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "estrogen response element binding", "id": "GO:0034056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034056", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "positive regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" }, { "name": "nuclear receptor-mediated steroid hormone signaling pathway", "id": "GO:0030518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030518", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T9B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" }, { "id": "PS51843", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000259", "start_pos": 730, "end_pos": 968, "start_aa": "Gln", "end_aa": "Ile", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T9B0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B0" }, { "id": "PS51030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000259", "start_pos": 602, "end_pos": 681, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 292, "end_pos": 294 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 320, "end_pos": 322 }, { "start_pos": 585, "end_pos": 587 }, { "start_pos": 59, "end_pos": 61 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7L6-1", "uniprot_ac": "A0AAA9T7L6", "uniprot_id": "A0AAA9T7L6_BOVIN", "mass": { "chemical_mass": 118026.0, "monoisotopic_mass": 118026.0 }, "refseq": { "ac": "NP_001179951", "name": "ribosomal protein S6 kinase delta-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179951" }, "gene_names": [ { "name": "RPS6KC1", "type": "recommended", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "name": "RPS6KC1", "type": "synonym", "evidence": [ { "id": "NP_001179951", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179951" } ] } ], "protein_names": [ { "name": "Ribosomal protein S6 kinase delta-1", "type": "recommended", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#names_and_taxonomy" } ] }, { "name": "52 kDa ribosomal protein S6 kinase", "type": "synonym", 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Plays a role in the recruitment of PRDX3 to early endosomes.", "evidence": [ { "database": "UniProtKB", "id": "E1BB43", "url": "https://www.uniprot.org/uniprotkb/E1BB43#function" }, { "database": "UniProtKB", "id": "ARBA00059823", "url": "https://www.uniprot.org/uniprotkb/ARBA00059823#function" }, { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6#function" }, { "database": "UniProtKB", "id": "A0A3Q1NG99", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG99#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPS6KC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6", "locus": { 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"533192", "url": "https://www.ncbi.nlm.nih.gov/gene/533192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051866", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533192", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533192", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHSSELW", "url": "https://omabrowser.org/oma/group/GHSSELW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNQ1", "url": "https://www.orthodb.org/?gene=A0A3Q1LNQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWG3", "url": "https://www.orthodb.org/?gene=A0A3Q1LWG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NG99", "url": "https://www.orthodb.org/?gene=A0A3Q1NG99", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BB43", "url": "https://www.orthodb.org/?gene=E1BB43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15508", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15508", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15508:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15508:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179951", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LNQ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NG99", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NG99-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NG99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB43", "url": "https://www.uniprot.org/uniprotkb/E1BB43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BB43-1", "url": "https://www.uniprot.org/uniprotkb/E1BB43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQPPGSLSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPVERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1061, "header": "tr|A0AAA9T7L6-1|A0AAA9T7L6_BOVIN Isoform 1 of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=1 CANONICAL=A0AAA9T7L6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#A0A3Q1LNQ1-1", "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQPPGSLSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDREVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPVERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1031, "header": "tr|A0A3Q1LNQ1-1|A0AAA9T7L6_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=1 CANONICAL=A0AAA9T7L6-1" }, "locus": { "chromosome": "16", "start_pos": 70552807, "end_pos": 70350056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068811.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068811.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058451.1" } ] } }, { "isoform_ac": "A0A3Q1LWG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#A0A3Q1LWG3-1", "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQPPGSLSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQWIGICLPMLGTQIRFLVQKDSTCHGAAKLVHHSYRACSLEPACCSH", "length": 1071, "header": "tr|A0A3Q1LWG3-1|A0AAA9T7L6_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=2 CANONICAL=A0AAA9T7L6-1" }, "locus": { "chromosome": "16", "start_pos": 70552807, "end_pos": 70357204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083599.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083599.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061760.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061760.2" } ] } }, { "isoform_ac": "A0A3Q1NG99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#A0A3Q1NG99-1", "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPVERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1030, "header": "tr|A0A3Q1NG99-1|A0AAA9T7L6_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=1 CANONICAL=A0AAA9T7L6-1" }, "locus": { "chromosome": "16", "start_pos": 70552807, "end_pos": 70350056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082560.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082560.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070820.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070820.1" } ] } }, { "isoform_ac": "A0AAA9T7L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#A0AAA9T7L6-1", "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQPPGSLSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPVERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1061, "header": "tr|A0AAA9T7L6-1|A0AAA9T7L6_BOVIN Isoform 1 of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=1 CANONICAL=A0AAA9T7L6-1" }, "locus": { "chromosome": "16", "start_pos": 70552807, "end_pos": 70350056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131606.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131606.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093926.1" } ] } }, { "isoform_ac": "E1BB43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6/entry#E1BB43-1", "sequence": { "sequence": "MTSPRERGADLARFYTVTEPQRHPRGYTVYKVTARIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDGSELIGPVEAYPDSLTDSFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGPNLSSDSSVLGTVFSDSEQNKTEEERESRSLFPSSLKSKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAETLSSLCAKPQLDDVSQPPGSLSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIVPRCVPNMVCLHKYIVSEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIEEVKKSSVAKVHLQQPACSPQDSTSFESGGSDGGATLQVLPLKTSLTPSSQDDSNQDDGGQDSSPQWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLSEEPFMKAERNDVDTKAIEKFPGQLATDGDSPSRQLKFFPGDDGLEAASSPRTSDSLSRSKNIPMEFFRIDSKDSTSELLGLDFGEKLYSLKSEPLKPFFTLSDGESTPRSVRTSESKVECVAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELEPMKDGVAVGPTKFTQTNIGIIESKLLETPDVLCLRLSTEQCQAQEEKGTEELSDPCGPEAHSITEKHYVQGDLGMLFLPAVDHSNTGDMSLLDSSESQFQGLSAVESPGTANNTEERLFHISDPLSGANEYNVNTDTLKTEEVLLFTDQADDLAKEEPAIFQRDLEPKQESGLAQEGDKEIHQIFEDLDKKLALNSRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPVERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1049, "header": "tr|E1BB43-1|E1BB43_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase delta-1 OS=Bos taurus OX=9913 GN=RPS6KC1 PE=4 SV=2 CANONICAL=A0AAA9T7L6-1" }, "locus": { "chromosome": "16", "start_pos": 70552807, "end_pos": 70350056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001565.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001565.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001565.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001565.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:533192", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533192", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KB60-1", "protein_name": "Ribosomal protein S6 kinase delta-1", "gene_name": "Rps6kc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTIYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSKQLQDFFKGGIISDGSELIGPAEAYPDSLANTFSECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRAFGLSVSADSSAVGAVASDIEPSKAEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRVTAQLDTGPQPPGALSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQHAEGGKLWSYISKFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQGSYSVESRGSDTGSMLKVLPLKTSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTLCNEYGQEKLDLTSLNEESVMQPEGENADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPRTSDSLRRSKNSPMEFFRIDSKDSTSELLGLDSGEKLHSLKPEPLKALFTLEDGDSPSQSFDAGKSQGESEAQDSISRGSDDSVPVISFKEAASEDVCSAEEGRPDLLVNLPGELQPTKETSAVDPTKFSQASIGRLEAPDVLCLRLSSEQCHDLGQEGPEELSHPTEFRPGGVTPERSAQADLGVLFTATVDHSSSQDQFLFSSLHSESDRLGQVEGAVTSQDLQESLFHIASPCSGAKEDSAHTDTATSEEVLLFTEPSKEGDSEAKVRSVGAGGAEKEVHQIFEDLDQRLAVSARLFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDLCDSDAIARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPDCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR", "length": 1045 }, "evidence": [ { "id": "A0AAA9T7L6", "url": "https://omabrowser.org/oma/group/A0AAA9T7L6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0R4IV01-1", "protein_name": "2.7.11.1", "gene_name": "rps6kc1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MISARNKDEIVRFYTVTDPTTHKKGYTVYKVTARIISRNNPEDIQEITVWKRYSDFKKLHQDLWQIYRNLCGQSELFPPFAKAKVFGRFDDSVIEKRRQCSEDLLQFSANIPALYGSSYIQDFFKGGEVQDSSELIGPAEPFSDFLADSLLDSSSEVSADISVVVDDLIVTNPCEHERGSSFSELNSFEVDGDSLVAVDDGMASGSLKQSSHSSRTLSFASGLKNCTGKLDYLEKASEQISLAVQKEVEQDFAEAFSYYRRGVDLLLQGVQGEVSPSRREAVKRKTAEYLMRAELISAQLIDGMGQSSTQSRALGSQCCGGSWTDQTHSDELKHYRVLGVIDKVLLVMDNRTQETFILKGLRKSSSCGRIKKTIVPRTVPNMVQLEKYIISEDSIFLLLQYAEGGQLWTHISKYLHGSSPDESVNMPMIQKVNSAAMHSTLTPVPTGSSSADSQALSLGEHPLAAQQPDSGGTSEEECTNSYLTLCNEYEQEKLEPEEDHSSFNPADAQKHTSLVLNTDSLCSPISIQELSFFTEEEQIASFMDQSTASPDSLNQSSPLERFQSDRNDACTALLPSDADVEVLEEPLQKPQVVSDLWRADGDQCSNELVPVISFKEAVQEDATVSCAVEGQPPDLLVNLPVLEADTVETVVEELIAFNAVAKTSPTFGGPDVLQGGEKAELELPIDLTTLPLYRPPAAPFGKDLIPSSPMLDGAISKTQTGCVEHEDLGLGLEGTSGEQEVEEVSKLFQELDKLAAVSLDTHIPEALVRSWAADIVVALDALHQEGIICRDLNPSNILLNHTGRVQLTYFCSWSDVEESCDPNAISKMYCAPEVGGICEETVASDWWSLGALLFELIVGKSLYQCHPAGIGRHSSLNIPEFVSEEARSLMEQLLQYNPVERLGAGVAGVEDIKSHPFFSHVNWTN", "length": 925 }, "evidence": [ { "id": "A0AAA9T7L6", "url": "https://omabrowser.org/oma/group/A0AAA9T7L6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Z8T4-1", "protein_name": "Ribosomal protein S6 kinase delta-1", "gene_name": "RPS6KC1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLSPRERGGELARFYTVTEPRRHPRGHTVYKVTARCSGSVADITALQLHWLSWCSAALGDRQERSGIVSRKNPEDVQEIVVWKRYSDFKKLHKDLWQIHKNLCRHTELFPPFAKAIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEEFFKGGEVHDGSELIGPVEPLSDSLTDNLSDCSSEVRKDLSGLDDVTLTSQSECGGFSSDSDLISLTVDVDSLAELDDGMASNHSSPSRAVGLCLTSEPPIQSTVASEQEWSKPEGERESHGLFSGSLKPKPGKQDYLEKAGELIKLALKKEEEEDYETAFSFYRKGVDLLLEGVQGESSPTRREAVKRKTAEYLMRAEKISTLYHKSSEDASVSMPPGSLSSRPSWNLRSPAEELKAFRVLGVIDKVLLVMDTRTQQTFILKGLRKSSEYSRSRTTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYVSKFLNTSPEQSFEIPEPKTFSSTKIHLERPTPSPKEISSSTDSRESYGENMLKVVPLRSSLTPSSQDDSSNQEDGQESSKWMDSASSSEEECTTSYLTLCNEYGQEKIDSGSLNEEPVVKGESQSLNIKEKSSLQKHAVVSSASFSSQVPSQELKLFIDDAESEIASPTRILDSLTKSKNSPMELFRIDSKDSTSELLGLDLGEKLYNLKSEPLKPLFSVPGHDRSLDALESKMGVRAQDTVSRGSNDSVPVISFKDAAFDDVSSVDEGRPDLLINLPSMSDGTEEAAASRPAKTDMDVLEVKLLETPDVLQLNSSAEQCKAFNQEPNHVTPQVGDPSPREVNGQSGVTQGALGTLFTSDPEVGSSEDGALFQGPGACSINMTSKEESVFVSNLLSGAQDVSLDRDTLRNEAVLLFSDQTEDFGKEETNLSLLPAAESEQTAPKREDKIAVAGEKDIHQIFQDLDERLAITSRFYIPEDCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWREVEDSCDNDAIERMYCAPEVGAILEETEACDWWSLGAILFELLTGKTLVECHPSGINTHTSLSIPDHVSKEARSLIQQLLQFNPAERLGAGVAGVEDIKSHPFFALIEWADLVK", "length": 1109 }, "evidence": [ { "id": "A0AAA9T7L6", "url": "https://omabrowser.org/oma/group/A0AAA9T7L6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BLK9-1", "protein_name": "Ribosomal protein S6 kinase delta-1", "gene_name": "Rps6kc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSPWGHSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWRRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTVFGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAYPDSPANAFPECGTEGFSSDSDLLSLTVDADSLAEVDDGMASRQGSPSRTFGLSLSTDSSAVGAVASDSEPSRVEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESVFLVLQRAEGGKLWSYISKFLNRSSQESLDIKEGRPSMPPRVCLQQPSASPQGGSSFESRGSDTGSMLKALPLKTSLTPSSQDDSNQEDDGQPSSPKWLDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSEESVMQPEGDKADTQAVSSPASLATGSVSPSTHLRVFSGGEDLEAVSSPPTSESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLEDGDSPSQSLDPGESKRESEAQDSVSRGSDDSVPVISFKEAAAEAISGAEEGRPDLLVNLPGELQPTKEASAMDPKFSQASAGRLDSKLLEAPDVLCLRLSSEQCHGLGPEGPEELSDPTEFCPGGVIPEHDAQADPGVLFEAAVDHRSSPDQFLFSSLRSESDRLGQVEVVVTAQALQESLFHISSPCSGANKEHSAYADTATSEEVLLFTEPTKEEANSLFQRGSEAQERGVGAGEADKEIHQIFEDLDKRLAASSRFFIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDGGHIQLTYFSRWSEVEDSCDSDAVARMYCAPEVGAVTEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPGCVSEEARSLIQQLLQFNPMERLGAGVAGVEDIKSHPFFTPVDWAELTR", "length": 1056 }, "evidence": [ { "id": "A0AAA9T7L6", "url": "https://omabrowser.org/oma/group/A0AAA9T7L6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96S38-1", "protein_name": "Inactive ribosomal protein S6 kinase delta-1", "gene_name": "RPS6KC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSPQDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKEEPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR", "length": 1066 }, "evidence": [ { "id": "A0AAA9T7L6", "url": "https://omabrowser.org/oma/group/A0AAA9T7L6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", 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"A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", 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"id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": 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"2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": 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{ "id": "A0AAA9T5D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D9" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 215, "start_aa": "Pro", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 56 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 162, "end_pos": 164 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", 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}, { "id": "PF22586", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22586", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LGK0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T639", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T639", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T639-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T639-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5S6", "url": "https://www.uniprot.org/uniprotkb/G5E5S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E5S6-1", "url": "https://www.uniprot.org/uniprotkb/G5E5S6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILESPSGWFLIFGLAVKPAQWGRGKTYRSPGQTAMEPGKGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 744, "header": "tr|A0AAA9T6U8-1|A0AAA9T6U8_BOVIN Isoform 1 of E3 ubiquitin-protein ligase Midline-1 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=1 CANONICAL=A0AAA9T6U8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8/entry#A0A3Q1LGK0-1", "sequence": { "sequence": "METLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 653, "header": "tr|A0A3Q1LGK0-1|A0AAA9T6U8_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase Midline-1 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=1 CANONICAL=A0AAA9T6U8-1" }, "locus": { "chromosome": "X", "start_pos": 56555726, "end_pos": 56465154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075000.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075000.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057592.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057592.2" } ] } }, { "isoform_ac": "A0AAA9SJ09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8/entry#A0AAA9SJ09-1", "sequence": { "sequence": "METLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 685, "header": "tr|A0AAA9SJ09-1|A0AAA9T6U8_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase Midline-1 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=1 CANONICAL=A0AAA9T6U8-1" }, "locus": { "chromosome": "X", "start_pos": 56555726, "end_pos": 56465154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132887.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132887.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083904.1" } ] } }, { "isoform_ac": "A0AAA9T639-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8/entry#A0AAA9T639-1", "sequence": { "sequence": "MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 735, "header": "tr|A0AAA9T639-1|A0AAA9T639_BOVIN Computationally mapped isoform of Midline 2 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=2 CANONICAL=A0AAA9T6U8-1" }, "locus": { "chromosome": "X", "start_pos": 56555726, "end_pos": 56452508, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107051.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107051.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092223.1" } ] } }, { "isoform_ac": "A0AAA9T6U8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8/entry#A0AAA9T6U8-1", "sequence": { "sequence": "MILESPSGWFLIFGLAVKPAQWGRGKTYRSPGQTAMEPGKGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 744, "header": "tr|A0AAA9T6U8-1|A0AAA9T6U8_BOVIN Isoform 1 of E3 ubiquitin-protein ligase Midline-1 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=1 CANONICAL=A0AAA9T6U8-1" }, "locus": { "chromosome": "X", "start_pos": 56555726, "end_pos": 56453050, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117328.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117328.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092475.1" } ] } }, { "isoform_ac": "G5E5S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8/entry#G5E5S6-1", "sequence": { "sequence": "MTKSKQIPMAESNLQALMRLSSNSESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKEESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAVGVAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 727, "header": "tr|G5E5S6-1|G5E5S6_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase Midline-1 OS=Bos taurus OX=9913 GN=MID2 PE=3 SV=3 CANONICAL=A0AAA9T6U8-1" }, "locus": { "chromosome": "X", "start_pos": 56555726, "end_pos": 56464184, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029287.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029287.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029287.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029287.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616821", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3AHW0-1", "protein_name": "Probable E3 ubiquitin-protein ligase MID2 isoform X1", "gene_name": "mid2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCSSTKPLESISAFQCPTCRYVITLNQRGLEGLKRNVTLQNIIDRFQKASVSGPNSPNESRRPRPYSATLGGSARGSPASSAMSLERVGCQFCDQEPPREAVKTCVTCEVSYCDRCLRATHPNKKPFTSHRLVEPVADAQLRGLACLEHENEKVNMYCVVDDQLICALCKLVGRHREHQVTSLSDRFDKLKAFQVSPARVSEAVMEASKTSAAQTLENNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLVEECDELVEIIRQRKQVIAVKIKESKVMKLRKLAQQIANCRQCLERSSALITQAEHSLKENDHTRFLQTARNVAERVAMATASSQVLIPDVNLNEAFDNFALDFSREKKILEGLDYLTAPNPPSIREELCTASHDTITVHWTSEDEFSVTSYELQYTIYTGQTNFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFFVKAINQAGSRNSEPARLKTNSQPFKLDPKTAHKKLRLSNDCLTMEKDESSLKKSHTPERFSGTGSYGAAGNVFIDSGCHYWEVLLGASTWYALGVAYKSAPKNEWSGKNSSSWVFSRCNNNFLVRHNNKESIVEASLQLRRVGVLLDYDNNTLSFYDAMNSQHIYTFDVSFLLPVAPTFMIWNKSLMIMSGLPVPDFVDCSEQQEGICRQQESPYVSGIKSCH", "length": 718 }, "evidence": [ { "id": "A0AAA9T6U8", "url": "https://omabrowser.org/oma/group/A0AAA9T6U8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0LKT0-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Mid2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPGSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVSDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSHFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 685 }, "evidence": [ { "id": "A0AAA9T6U8", "url": "https://omabrowser.org/oma/group/A0AAA9T6U8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NCH4-1", "protein_name": "Midline 2", "gene_name": "MID2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "METLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILLSGCSSGESIEPLSAFQCPTCRYVISLNHRGLEGLKRNVTLQNIIDRFQKASLSGPNSPSESRRDRPYRPNPSMSVGGERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDAHFRGLTCLEHENEKVNMYCVADDQLICALCKLVGRHRDHQVASLSDRFEKLKQTLETNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELMEIIRQRKQVIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDHARFLQTARNVAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSVREELCTASHDTITVHWISEDEFSVSSYELQYTIFTGQANFISLYNSMDSWMIVPNIKQNHYTVHGLQSGTRYIFLVKAINQAGSRNSEPARLKTNSQPFKLDPKMAHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNVFIDSGCHYWEVVVGSSTWYAIGVAYKSAPKNEWIGKNSSSWVFSRCNNNFVVRHNNKEMLVEVHPQMKRLGVLLDYDNNALSFYDPANSLHLHTFEVSFILPVCPTFTIWNKSLMILSGLPAPDFIDYPEQQECNCRPQESPYVSGMKACH", "length": 687 }, "evidence": [ { "id": "A0AAA9T6U8", "url": "https://omabrowser.org/oma/group/A0AAA9T6U8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9QUS6-1", "protein_name": "Probable E3 ubiquitin-protein ligase MID2", "gene_name": "Mid2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVSDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPQLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKACH", "length": 705 }, "evidence": [ { "id": "A0AAA9T6U8", "url": "https://omabrowser.org/oma/group/A0AAA9T6U8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJV3-1", "protein_name": "Probable E3 ubiquitin-protein ligase MID2", "gene_name": "MID2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGESPASVVLNASGGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPHLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKTCH", "length": 735 }, "evidence": [ { "id": "A0AAA9T6U8", "url": "https://omabrowser.org/oma/group/A0AAA9T6U8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6U8" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6U8", "url": 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"length": 1349, "header": "tr|A0A3Q1LL65-1|A0AAA9T7M1_BOVIN Computationally mapped isoform of Early endosome antigen 1 OS=Bos taurus OX=9913 GN=EEA1 PE=1 SV=3 CANONICAL=A0AAA9T7M1-1" }, "locus": { "chromosome": "5", "start_pos": 22777435, "end_pos": 22650495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079311.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079311.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057205.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057205.3" } ] } }, { "isoform_ac": "A0A3Q1M5J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1/entry#A0A3Q1M5J6-1", "sequence": { "sequence": "MKRCITAIDLSEHYQKVHAENETRGQELLNDSSVTGFICPQCMKSLGSADELFKHYEAVHDAGNDSSHGGEALALKRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKFQGLQQQESKPDGLVADSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQQVTHLTEELNKEAAVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQTEYTNSEAVISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQNLTEKLQKKELDYTQLEEKHNEECMSKKSIQASLHQKDLDCQQLQSRLSASETSLQRIQAELGEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKDQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEELKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLESSINELNSQLNESKEKVSQLDIQVKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTTKLQDKQEHCSQLESHLKEYKEKHLSLEQKTEELEGQIKKLEADMLEVKASKEQALQGLQQQRQLNTDLELRATELSKQLEMEKETVSNTKLDLQKKSEALENTKQMLTKQEEEKTMLKQEIENLSQDAKMQHKELNDRIQTAVTELQKVKVEKDSLVAELSAAKEKLSKVSDCLKNSQSEFEKENQKGKAVILDLEKTCKELKHQLQVQTESLHKEQNEMKKSLEKEKETSHQLKLELSSMQGQVIQAQDSLKQKEKEEQQLQSNINELKQLTEQKKKQIETLQGEVKIAVSQKTELENKLQQQSMQAAQELAAEKQKISVLQNTYEKSQENLKQLQSDFYGKESELLATRQDLKSIEEKLSLAQEDLISNRNQIGNQNKLIQELKTTKTTLEQDLAKKEQQLKEQNKALQDMQKEKSLKEKELVNEKSKLAETEEIKCRQEKEIAKLSEELKSHKQESIKEITNLKDAKQLLIQQKLELQGKVDSLKATLEQEKKTQQMLKEQMKKEEDELKKEFMEKEAKLHSEIKEKEVGMKKHEENGAKLTMQITALNENLGTIKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALTRKWAEDSEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDGCFNDLQG", "length": 1406, "header": "tr|A0A3Q1M5J6-1|A0A3Q1M5J6_BOVIN Computationally mapped isoform of Early endosome antigen 1 OS=Bos taurus OX=9913 GN=EEA1 PE=1 SV=3 CANONICAL=A0AAA9T7M1-1" }, "locus": { "chromosome": "5", "start_pos": 22733710, "end_pos": 22650495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081019.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081019.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063541.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063541.3" } ] } }, { "isoform_ac": "A0A3Q1ML65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1/entry#A0A3Q1ML65-1", "sequence": { "sequence": "MLRRILQRTPGRVGSQGSDLDSSAAPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSSHGGEALALKRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKFQGLQQQESKPDGLVADSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQQVTHLTEELNKEAAVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQTEYTNSEAVISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQNLTEKLQKKELDYTQLEEKHNEECMSKKSIQASLHQKDLDCQQLQSRLSASETSLQRIQAELGEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKDQHGLQLQSEINQVDSLPSEPPGKSLPSKGRSESEVALSCPTLCDPMDSPCTNLHPWDFLGKSTGLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEELKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLESSINELNSQLNESKEKVSQLDIQVKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTTKLQDKQEHCSQLESHLKEYKEKHLSLEQKTEELEGQIKKLEADMLEVKASKEQALQGLQQQRQLNTDLELRATELSKQLEMEKETVSNTKLDLQKKSEALENTKQMLTKQEEEKTMLKQEIENLSQDAKMQHKELNDRIQTAVTELQKVKVEKDSLVAELSAAKEKLSKVSDCLKNSQSEFEKENQKGKAVILDLEKTCKELKHQLQVQTESLHKEQNEMKKSLEKEKETSHQLKLELSSMQGQVIQAQDSLKQKEKEEQQLQSNINELKQLTEQKKKQIETLQGEVKIAVSQKTELENKLQQQSMQAAQELAAEKQKISVLQNTYEKSQENLKQLQSDFYGKESELLATRQDLKSIEEKLSLAQEDLISNRNQIGNQNKLIQELKTTKTTLEQDLAKKEQQLKEQNKALQDMQKEKSLKEKELVNEKSKLAETEEIKCRQEKEIAKLSEELKSHKQESIKEITNLKDAKQLLIQQKLELQGKVDSLKATLEQEKKTQQMLKEQMKKEEDELKKEFMEKEAKLHSEIKEKEVGMKKHEENGAKLTMQITALNENLGTIKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALTRKWAEDSEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDGCFNDLQG", "length": 1462, "header": "tr|A0A3Q1ML65-1|A0AAA9T7M1_BOVIN Computationally mapped isoform of Early endosome antigen 1 OS=Bos taurus OX=9913 GN=EEA1 PE=1 SV=2 CANONICAL=A0AAA9T7M1-1" }, "locus": { "chromosome": "5", "start_pos": 22777435, "end_pos": 22650495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080956.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080956.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072391.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072391.2" } ] } }, { "isoform_ac": "A0AAA9T7M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1/entry#A0AAA9T7M1-1", "sequence": { "sequence": "MILSFASTQGLSASSRNDGPVQTPGRVGSQGSDLDSSAAPINTVDVNNESSSEGFICPLCMKRCITAIDLSEHYQKVHAENETRGQELLNDSSVTGFICPQCMKSLGSADELFKHYEAVHDAGNDSSHGGEALALKRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKFQGLQQQESKPDGLVADSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQQVTHLTEELNKEAAVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQTEYTNSEAVISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQNLTEKLQKKELDYTQLEEKHNEECMSKKSIQASLHQKDLDCQQLQSRLSASETSLQRIQAELGEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKDQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEELKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLESSINELNSQLNESKEKVSQLDIQVKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTTKLQDKQEHCSQLESHLKEYKEKHLSLEQKTEELEGQIKKLEADMLEVKASKEQALQGLQQQRQLNTDLELRATELSKQLEMEKETVSNTKLDLQKKSEALENTKQMLTKQEEEKTMLKQEIENLSQDAKMQHKELNDRIQTAVTELQKVKVEKDSLVAELSAAKEKLSKVSDCLKNSQSEFEKENQKGKAVILDLEKTCKELKHQLQVQTESLHKEQNEMKKSLEKEKETSHQLKLELSSMQGQVIQAQDSLKQKEKEEQQLQSNINELKQLTEQKKKQIETLQGEVKIAVSQKTELENKLQQQSMQAAQELAAEKQKISVLQNTYEKSQENLKQLQSDFYGKESELLATRQDLKSIEEKLSLAQEDLISNRNQIGNQNKLIQELKTTKTTLEQDLAKKEQQLKEQNKALQDMQKEKSLKEKELVNEKSKLAETEEIKCRQEKEIAKLSEELKSHKQESIKEITNLKDAKQLLIQQKLELQGKVDSLKATLEQEKKTQQMLKEQMKKEEDELKKEFMEKEAKLHSEIKEKEVGMKKHEENGAKLTMQITALNENLGTIKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALTRKWAEDSEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDGCFNDLQG", "length": 1466, "header": "tr|A0AAA9T7M1-1|A0AAA9T7M1_BOVIN Isoform 1 of Early endosome antigen 1 OS=Bos taurus OX=9913 GN=EEA1 PE=1 SV=1 CANONICAL=A0AAA9T7M1-1" }, "locus": { "chromosome": "5", "start_pos": 22778122, "end_pos": 22650495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104816.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104816.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091848.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091848.1" } ] } }, { "isoform_ac": "F1MN61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1/entry#F1MN61-1", "sequence": { "sequence": "GFICPQCMKSLGSADELFKHYEAVHDAGNDSSHGGEALALKRDDITLLRQEVQDLQASLKEEKWYSEELKKELEKFQGLQQQESKPDGLVADSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQQVTHLTEELNKEAAVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQTEYTNSEAVISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQNLTEKLQKKELDYTQLEEKHNEECMSKKSIQASLHQKDLDCQQLQSRLSASETSLQRIQAELGEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKDQHGLQLQSEINQVRFSTKMYKEGYSSASGRLNPWGDPVSLLKRIYIFFLKLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLESSINELNSQLNESKEKVSQLDIQVKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTTKLQDKQEHCSQLESHLKEYKEKHLSLEQKTEELEGQIKKLEADMLEVKASKEQALQGLQQQRQLNTDLELRATELSKQLEMEKETVSNTKLDLQKKSEALENTKQMLTKQEEEKTMLKQEIENLSQDAKMQHKELNDRIQTAVTELQKVKVEKDSLVAELSAAKEKLSKVSDCLKNSQSEFEKENQKGKAVILDLEKTCKELKHQLQVQTESLHKEQNEMKKSLEKEKETSHQLKLELSSMQGQVIQAQDSLKQKEKEEQQLQSNINELKQLTEQKKKQIETLQGEVKIAVSQKTELENKLQQQSMQAAQELAAEKQKISVLQNTYEKSQENLKQLQSDFYGKESELLATRQDLKSIEEKLSLAQEDLISNRNQIGNQNKLIQELKTTKTTLEQDLAKKEQQLKEQNKALQDMQKEKSLKEKELVNEKSKLAETEEIKCRQEKEIAKLSEELKSHKQESIKEITNLKDAKQLLIQQKLELQGKVDSLKATLEQEKKTQQMLKEQMKKEEDELKKEFMEKEAKLVS", "length": 1168, "header": "tr|F1MN61-1|A0AAA9T7M1_BOVIN Computationally mapped isoform of Early endosome antigen 1 OS=Bos taurus OX=9913 GN=EEA1 PE=1 SV=3 CANONICAL=A0AAA9T7M1-1" }, "locus": { "chromosome": "5", "start_pos": 22729300, "end_pos": 22653633, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047703.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047703.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044884.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044884.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-168138", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168138", "resource": "Reactome", "description": "Toll Like Receptor 9 (TLR9) Cascade" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "1-phosphatidylinositol binding", "id": "GO:0005545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005545", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "GTP-dependent protein binding", "id": "GO:0030742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030742", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "axonal spine", "id": "GO:0044308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044308", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "postsynaptic early endosome", "id": "GO:0098842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098842", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M1", "url": 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help reseal the ruptured membrane.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9F0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F0#function" }, { "database": "UniProtKB", "id": "ARBA00058649", "url": "https://www.uniprot.org/uniprotkb/ARBA00058649#function" }, { "database": "UniProtKB", "id": "F1MU85", "url": "https://www.uniprot.org/uniprotkb/F1MU85#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BROX", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2", "locus": { "chromosome": "16", "start_pos": 26226551, "end_pos": 26205238, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007595", "url": "https://www.ensembl.org/id/ENSBTAG00000007595" } ] } } ], "crossref": [ { "id": "A0AAA9T5V2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5V2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09243", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09243", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522319", "url": "https://www.ncbi.nlm.nih.gov/gene/522319", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038499", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038499", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038898", "url": 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"https://www.uniprot.org/uniprotkb/F1MU85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGVVTGPAASKICSDLRSSRARLLELFTDLSCNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSITEDEAKEVHRSLKIAAGIFKHLKESHIPKLITPAEKGRDLEARLIEAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHALSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKFYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKVPTEAPQLELKANYGLVEPVPFEFPPPSAHWTPETLAAFDLTKRPKDDSAKPKPEEVVKPVKEPDIKPQKDTGCYIS", "length": 379, "header": "tr|A0AAA9T5V2-1|A0AAA9T5V2_BOVIN Isoform 1 of BRO1 domain-containing protein BROX OS=Bos taurus OX=9913 GN=BROX PE=3 SV=1 CANONICAL=A0AAA9T5V2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9F0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2/entry#A0AAA9S9F0-1", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000093223.1" } ] } }, { "isoform_ac": "A0AAA9TRE3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2/entry#A0AAA9TRE3-1", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGVVTGPAASKICSDLRSSRARLLELFTDLSCNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLITPAEKGRDLEARLIEAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHALSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKFYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGNLVKNTLEKCQRENGFMLNPNQKKW", "length": 338, "header": "tr|A0AAA9TRE3-1|A0AAA9TRE3_BOVIN Computationally mapped isoform of BRO1 domain-containing protein BROX OS=Bos taurus OX=9913 GN=BROX PE=3 SV=1 CANONICAL=A0AAA9T5V2-1" }, "locus": { "chromosome": "16", "start_pos": 26224186, "end_pos": 26208039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129455.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129455.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099878.1" } ] } }, { "isoform_ac": "F1MU85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2/entry#F1MU85-1", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGVVTGPAASKICSDLRSSRARLLELFTDLSCNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLITPAEKGRDLEARLIEAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHALSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKFYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKVPTEAPQLELKANYGLVEPVPFEFPPPSAHWTPETLAAFDLTKRPKDDSAKPKPEEVVKPVKEPDIKPQKDTGCYIS", "length": 411, "header": "tr|F1MU85-1|A0AAA9T5V2_BOVIN Computationally mapped isoform of BRO1 domain-containing protein BROX OS=Bos taurus OX=9913 GN=BROX PE=3 SV=2 CANONICAL=A0AAA9T5V2-1" }, "locus": { "chromosome": "16", "start_pos": 26224245, "end_pos": 26208039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009990.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009990.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009990.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009990.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 268, "start_aa": "Thr", "end_pos": 268, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr268", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:522319", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522319", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1THH2-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "BROX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGVITGPAASKICSDLRSSRARLLELFTDLSCNPEMMKSAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIAKLITPAEKGRDLEARLLEAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHTLSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKFYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGTLVKNTLEKCQRENGFIYFQKVPTEAPQLELKANYGLVEPVPFEFPPLSSHWTPEAMAAFDLTQRPKDDRGKPKPEEVVKPVKEPDIKPQKDTGCSVS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QPJ1-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "Brox", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGMITGPAASKICNDLRSSRTRLLELFTDLSCNPETMKNAADLYFSLLQGFINSLGDSTQESKLRYVQSFKWTDTLQGHVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLLTPAEKGQDLEARLIDAYVIQCQAEAQEVTIARAIELQHAPGLIAALAYETASFYQRADHTLSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKLYTEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQKIPTEAPQLELKANYGLVEPVPFEFPPMSAHWTPEALAAFDLTKRPKDDSVKPKPEEEVKPVKEPDIKPQKDTGCSVS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A3KQV2-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "brox", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNLYGVASSPAANKICNDLRTARARLLDMFTDATCSPDTLKKSSDEYFALLQGFILPLDGTTQENKLRFIQNFKWTDTLQGNIASAQQDAVFELVSMAFNVALWYTKFASRLAGKENITEEEAKDVHKSLKIAAGIFKTLKETHIPRLITPAEKGRDLEPRVIDTYIVQSQAEAQEVTIARAIELKHNASLIAALAFETANFYQKADHTLNTLDPECSSKWKKYLQLKQHFYMAYAHCYHGQTLLAGDKCGEAIRSLQEAEKCYSRAEVLCKEYRQMKGPGSTAKPSEQLFFKKLGAVIKNTLEKCQRENGFIYFHKVPAEAPALELKASYGLAEPTAFELPPLSAQCTPEVYATFDLTRGHKDDKAKAKPEEEIKPVKEPDLKPQKDTGCVVC", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BY06-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "BROX", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTHWFHRNPLKATAPVQFNYYGVATTPASSKICNDLRLSRTRLLELFTDLSCNPEMMKNATDLYFSLLQGFILSLDDSSQECKLRYIQNFKWTDTLQGHVPCAQQDAVFELVSMGFNVALWYTKYASRLAGKEDITEDEAKDVHRSLKIAAGIFKHLKECHIPKLITPVEKGRDLEARLIDSYIIQCQAEAQEVTIARAIELKHNPGLIAALAYETANFYQKADQTLSSLDPTYAGKWRKYLNLKSCFYMAYAYCYHGQTLLASDKCGEAIRSLQESEKFFAKAEALCKEYGETKGPGTTAKPSGHLFFRKLGSLIKNTLEKCQRENGFIYFQKVPAEAPQLELKANYGLVEPVPFEFPALNAHWTPETLAAFDLTKRPKDDTAKPKPDEEVKPLKEPDIKPQKDSGCRIS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q4V8K5-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "Brox", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGMITGPPASKICNDLRSARTRLLELFTDLSCNPETMKNAADLYFSLLQGFINSVGDSTQESKLRYIQNFKWTDTLQGHVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLLTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETASFYQKADHTLSSLEPAHSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKLYAEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQKIPTEAPQLELKANYGLVEPVPFEFPPMSALWTPEALAAFDLTKRPKDDSIKPKPEEEVKPVKEPDIKPQKDTGCSVS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VW32-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "BROX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGVVTGPSASKICNDLRSSRARLLELFTDLSCNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHLPKLITPAEKGRDLESRLIEAYVIQCQAEAQEVTIARAIELKHAPGLIAALAYETANFYQKADHTLSSLEPAYSAKWRKYLHLKMCFYTAYAYCYHGETLLASDKCGEAIRSLQEAEKLYAKAEALCKEYGETKGPGPTVKPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKIPTEAPQLELKANYGLVEPIPFEFPPTSVQWTPETLAAFDLTKRPKDDSTKPKPEEEVKPVKEPDIKPQKDTGCYIS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K2Q7-1", "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "Brox", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTHWFHRNPLKATAPVSFNYYGMITGPPASKICNDLRSARTRLLELFTDLSCNPETMKNAADLYFSLLQGFINSVGDSTQESKLRYIQNFKWTDTLQGHVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLLTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYDTASFYQKADHTLSSLEPAHSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKLYAEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQKIPTEAPQLELKANYGLVEPVPFEFPPMSAHWTPEALAAFDLTKRPKDDSVKPKPEEDVKPVKEPDIRPQKDTGCSVS", "length": 411 }, "evidence": [ { "id": "A0AAA9T5V2", "url": "https://omabrowser.org/oma/group/A0AAA9T5V2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitotic nuclear membrane reassembly", "id": "GO:0007084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007084", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V2" }, { "id": "PS51180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRO1", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 379, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 268 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6R9-1", "uniprot_ac": "A0AAA9T6R9", "uniprot_id": "A0AAA9T6R9_BOVIN", "mass": { "chemical_mass": 162282.0, "monoisotopic_mass": 162282.0 }, "refseq": { "ac": "XP_024852867", "name": "SR-related and CTD-associated factor 8 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852867" }, "gene_names": [ { "name": "SCAF8", "type": "recommended", "evidence": [ { "id": "A0AAA9T6R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ] }, { "name": "SCAF8", "type": "synonym", "evidence": [ { "id": "XP_024852867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852867" } ] } ], "protein_names": [ { "name": "SR-related CTD associated factor 8", "type": "synonym", "evidence": [ { "id": "A0AAA9T6R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#names_and_taxonomy" } ] }, { "name": "SR-related and CTD-associated factor 8 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852867", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852867" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCAF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9", "locus": { "chromosome": "9", "start_pos": 91605839, "end_pos": 91411839, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031917", "url": "https://www.ensembl.org/id/ENSBTAG00000031917" } ] } } ], "crossref": [ { "id": "A0AAA9T6R9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6R9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031917", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031917", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12462", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12462", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17004", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17004", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100298738", "url": "https://www.ncbi.nlm.nih.gov/gene/100298738", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100298738", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298738", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZ51", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MYK6", "url": "https://www.orthodb.org/?gene=F1MYK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23140:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23140:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04818", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04818", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024852867", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852867", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDZ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSD5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSD5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYK6", "url": "https://www.uniprot.org/uniprotkb/F1MYK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYK6-1", "url": "https://www.uniprot.org/uniprotkb/F1MYK6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPRGGPGPRGPDARGRAGRRRGSPSCAARLASAILDAAAAAASASSSVFAARRWFLRAPSGGEAKQEPAGGKRKEGVERSRGPGLEGGSPRPSGAEKRRRRGPAPPPPSAAADPPRQRLCSPARRSACPSGHAGASPPLRESPSPPVLASPFPSGPGGSQRPGPPPPVPAAVGAPAPSHPPPSSRRRRRPRLALPTQCSGRRLFRRRAPGLRTDNMEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEVNKKSDTVADVESEPVVESTETEGT", "length": 1484, "header": "tr|A0AAA9T6R9-1|A0AAA9T6R9_BOVIN Isoform 1 of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=2 CANONICAL=A0AAA9T6R9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#A0A3Q1LZ51-1", "sequence": { "sequence": "MDTRSILYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEVNKKSDTVADVESEPVVESTETEGT", "length": 1264, "header": "tr|A0A3Q1LZ51-1|A0AAA9T6R9_BOVIN Computationally mapped isoform of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=3 CANONICAL=A0AAA9T6R9-1" }, "locus": { "chromosome": "9", "start_pos": 91498307, "end_pos": 91418155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074669.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074669.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060963.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060963.3" } ] } }, { "isoform_ac": "A0A3Q1MDZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#A0A3Q1MDZ6-1", "sequence": { "sequence": "MWYRVLRNSFRNTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEVNKKSDTVADVESEPVVESTETEGT", "length": 1186, "header": "tr|A0A3Q1MDZ6-1|A0AAA9T6R9_BOVIN Computationally mapped isoform of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=2 CANONICAL=A0AAA9T6R9-1" }, "locus": { "chromosome": "9", "start_pos": 91498307, "end_pos": 91458807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068799.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068799.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069192.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069192.3" } ] } }, { "isoform_ac": "A0A3Q1MSD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#A0A3Q1MSD5-1", "sequence": { "sequence": "MDTRSIADSLPLSHQGSPVQLYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEVNKKSDTVADVESEPVVESTETEGT", "length": 1278, "header": "tr|A0A3Q1MSD5-1|A0AAA9T6R9_BOVIN Computationally mapped isoform of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=2 CANONICAL=A0AAA9T6R9-1" }, "locus": { "chromosome": "9", "start_pos": 91498307, "end_pos": 91418155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069259.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069259.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072925.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072925.2" } ] } }, { "isoform_ac": "A0AAA9T6R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#A0AAA9T6R9-1", "sequence": { "sequence": "MVPRGGPGPRGPDARGRAGRRRGSPSCAARLASAILDAAAAAASASSSVFAARRWFLRAPSGGEAKQEPAGGKRKEGVERSRGPGLEGGSPRPSGAEKRRRRGPAPPPPSAAADPPRQRLCSPARRSACPSGHAGASPPLRESPSPPVLASPFPSGPGGSQRPGPPPPVPAAVGAPAPSHPPPSSRRRRRPRLALPTQCSGRRLFRRRAPGLRTDNMEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEVNKKSDTVADVESEPVVESTETEGT", "length": 1484, "header": "tr|A0AAA9T6R9-1|A0AAA9T6R9_BOVIN Isoform 1 of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=2 CANONICAL=A0AAA9T6R9-1" }, "locus": { "chromosome": "9", "start_pos": 91498307, "end_pos": 91411954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091481.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091481.2" } ] } }, { "isoform_ac": "F1MYK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9/entry#F1MYK6-1", "sequence": { "sequence": "MDTRSILYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLNPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIFHQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEVQDAVEEEIFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWETVKSSEPVKETVQTTQSPPPAEKETVVTTQAEVFPPPVAMLQIPVAPAVPAVNLVPPTFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVASSLATATLPAGNVFNPPTKQAEPEEKVPHLIDHQISSAENTRSVIPNDISSGPAILGQPPNVTSNSGILGVQRPNVSSNNEILGVRPSNVSSSSGIIGPQPPNILNNSGILGLQPPNVSSSSGLLGVLPPNMPNNSGLIGVQPPGIPSTSGLLGTQPPAGPQNLPPLNLPNQRMPAMPMLDIRPGLIPQTPGPRFPLIQPGIPPQRGLPPPAVLDSALHPPPRGPFPPGDIFSPPERPFLVPGRQNVDNVPNPEKRIPLGNDNIQQEGDRDYRFPPIEPREAISRPPPVDVRDVVGRPVDPREGPGRPPLDARDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGPRDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWIPPPHARVFEFFEGATSQRKGDNVPQVNGENTERHAQPPPLPAQSDPELYEKLASSSEDRMTQKIMEL", "length": 1249, "header": "tr|F1MYK6-1|A0AAA9T6R9_BOVIN Computationally mapped isoform of SR-related CTD associated factor 8 OS=Bos taurus OX=9913 GN=SCAF8 PE=4 SV=5 CANONICAL=A0AAA9T6R9-1" }, "locus": { "chromosome": "9", "start_pos": 91605788, "end_pos": 91418155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045257.6", "url": "https://www.ensembl.org/id/ENSBTAT00000045257.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042661.6", "url": "https://www.ensembl.org/id/ENSBTAP00000042661.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100298738", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100298738", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ], "pmid": "" }, { "name": "RNA polymerase II C-terminal domain phosphoserine binding", "id": "GO:1990269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990269", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6R9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6R9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 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"https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13748", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13748", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13748:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13748:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07683", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07683", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SV81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T844-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKJ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFK3", "url": "https://www.uniprot.org/uniprotkb/E1BFK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFK3-1", "url": "https://www.uniprot.org/uniprotkb/E1BFK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRAVDSADEEEEQAEEDCPELVPIEAKQREVKEEEEKSGPGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGAVASMFWVDAELGVDIYLDGIITVVDSKYGLKIIFWKLSMKRNKTNMHLAEEKPDGLINEASRQVALADIIIINKTDLVSEEDLNKLRTTVRSINGLGKILETQRSRVDLAKVLDLHAFDSLSGISLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQNLLWEKNVRNRDDACMEVIRLKGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 413, "header": "tr|A0AAA9T844-1|A0AAA9T844_BOVIN Isoform 1 of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=1 CANONICAL=A0AAA9T844-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SV81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844/entry#A0AAA9SV81-1", "sequence": { "sequence": "SRAVDSADEEEEQAEEDCPELVPIEAKQREVKEEEEKSGPGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGIITVVDSKYGLKHLAEEKPDGLINEASRQVALADIIIINKTDLVSEEDLNKLRTTVRSINGLGKILETQRSRVDLAKVLDLHAFDSLSGISLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQNLLWEKNVRNRDDACMEVIRLKGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 377, "header": "tr|A0AAA9SV81-1|A0AAA9T844_BOVIN Computationally mapped isoform of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=1 CANONICAL=A0AAA9T844-1" }, "locus": { "chromosome": "8", "start_pos": 44344640, "end_pos": 44298892, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094466.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094466.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090376.1" } ] } }, { "isoform_ac": "A0AAA9T0Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844/entry#A0AAA9T0Q4-1", "sequence": { "sequence": "MSGTALTIPPTFIEHARGACPVPVGACLKGVAVLSPSPGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGAVASMFWVDAELGVDIYLDGIITVVDSKYGLKHLAEEKPDGLINEASRQVALADIIIINKTDLVSEEDLNKLRTTVRSINGLGKILETQRSRVDLAKVLDLHAFDSLSGISLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQNLLWEKNVRNRDDACMEVIRLKGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 382, "header": "tr|A0AAA9T0Q4-1|A0AAA9T844_BOVIN Computationally mapped isoform of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=2 CANONICAL=A0AAA9T844-1" }, "locus": { "chromosome": "8", "start_pos": 44344640, "end_pos": 44298622, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112683.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112683.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091271.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091271.2" } ] } }, { "isoform_ac": "A0AAA9T844-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844/entry#A0AAA9T844-1", "sequence": { "sequence": "MSRAVDSADEEEEQAEEDCPELVPIEAKQREVKEEEEKSGPGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGAVASMFWVDAELGVDIYLDGIITVVDSKYGLKIIFWKLSMKRNKTNMHLAEEKPDGLINEASRQVALADIIIINKTDLVSEEDLNKLRTTVRSINGLGKILETQRSRVDLAKVLDLHAFDSLSGISLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQNLLWEKNVRNRDDACMEVIRLKGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 413, "header": "tr|A0AAA9T844-1|A0AAA9T844_BOVIN Isoform 1 of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=1 CANONICAL=A0AAA9T844-1" }, "locus": { "chromosome": "8", "start_pos": 44344640, "end_pos": 44298889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092977.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092977.1" } ] } }, { "isoform_ac": "A0AAA9THM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844/entry#A0AAA9THM4-1", "sequence": { "sequence": "SRAVDSADEEEEQAEEDCPELVPIEAKQREVKEEEEKSGPGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGAVASMFWVDAELGVDIYLDGIITVVDSKYGLKHLAEEKPDGLINEASRSINGLGKILETQRSSLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQNLLWEKNVRNRDDACMEVIRLKGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 349, "header": "tr|A0AAA9THM4-1|A0AAA9THM4_BOVIN Computationally mapped isoform of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=1 CANONICAL=A0AAA9T844-1" }, "locus": { "chromosome": "8", "start_pos": 44344640, "end_pos": 44298892, "strand": "-", "evidence": [ { "database": "Ensembl 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"Ensembl Peptide", "id": "ENSBTAP00000097475.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097475.1" } ] } }, { "isoform_ac": "E1BFK3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844/entry#E1BFK3-1", "sequence": { "sequence": "MSRAVDSADEEEEQAEEDCPELVPIEAKQREVKEEEEKSGPGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRIAVILNEFGEGSAVEKSLAVSQDGELYEEWLELRNGCLCCSVKDNGLRAIENLMKKKGKFDYILLETTGLADPGAVASMFWVDAELGVDIYLDGIITVVDSKYGLKHLAEEKPDGLINEASRQVALADIIIINKTDLVSEEDLNKLRTTVRSINGLGKILETQRSRVDLAKVLDLHAFDSLSGISLQKKLQHVPTTQPHLDQSIITVTFEVPGNAEEESLNVYIQGLVSIKDKPQQVIVQGVHELYDLEETPVNWEDDSERTNRLVLIGRNLDKDILKQLFIATVTETEKRWTTHFQEDQVCP", "length": 376, "header": "tr|E1BFK3-1|E1BFK3_BOVIN Computationally mapped isoform of Zn regulated GTPase metalloprotein activator 1 OS=Bos taurus OX=9913 GN=ZNG1A PE=3 SV=3 CANONICAL=A0AAA9T844-1" }, "locus": { "chromosome": "8", "start_pos": 44344640, "end_pos": 44298889, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000335.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000335.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000335.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000335.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "zinc chaperone activity", "id": "GO:0140827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" }, { "name": "intracellular zinc ion homeostasis", "id": "GO:0006882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T844", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T844" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] } ] }, { "uniprot_ac": "A0AAA9S5W8", "gene_name": "RAB12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9S5W8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W8" } ] } ] }, { "uniprot_ac": "A0AAA9SGM6", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SGM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM6" } ] } ] }, { "uniprot_ac": "A0AAA9SLN0", "gene_name": "RAB23", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SLN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLN0" } ] } ] }, { "uniprot_ac": "A0AAA9SV95", "gene_name": "RAB34", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SV95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV95" } ] } ] }, { "uniprot_ac": "A0AAA9SVR8", "gene_name": "LOC789148", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0AAA9SVR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVR8" } ] } ] }, { "uniprot_ac": "A0AAA9T9T1", "gene_name": "ERAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ] }, { 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"id": "R-BTA-198753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-202670", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202670", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-389513", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389513", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432142", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432142", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5673000", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673000", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5675221", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5675221", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804757", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811558", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-69273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9860927", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9860927", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LT87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI59", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6W7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQN0", "url": "https://www.uniprot.org/uniprotkb/F1MQN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQN0-1", "url": "https://www.uniprot.org/uniprotkb/F1MQN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISAMAQRLRKLDFPVKDSEEPSTPGPDKNHFLRPREPGEDTGKAQRDRVARVASEEAVEADQFRGPGAAKVSPEQTPPLLTGPMLSKDPTYCLKGEQM", "length": 798, "header": "tr|A0AAA9T6W7-1|A0AAA9T6W7_BOVIN Isoform 1 of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=1 CANONICAL=A0AAA9T6W7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0A3Q1LT87-1", "sequence": { "sequence": "MAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISAMAQRLRKLDFPVKDSEEPSTPGPDKNHFLRPREPGEDTGKPEMSTRAQGTQPPSILFKIPPKA", "length": 660, "header": "tr|A0A3Q1LT87-1|A0AAA9T6W7_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=2 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22089957, "end_pos": 22057780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071106.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071106.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060267.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060267.2" } ] } }, { "isoform_ac": "A0A3Q1LUG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0A3Q1LUG0-1", "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCVSLCLSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISGMSVSAFQLWLGLTGCEWC", "length": 686, "header": "tr|A0A3Q1LUG0-1|A0AAA9T6W7_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=2 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22090275, "end_pos": 22069109, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066950.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066950.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060767.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060767.2" } ] } }, { "isoform_ac": "A0AAA9RUN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0AAA9RUN1-1", "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKCPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISVLALA", "length": 662, "header": "tr|A0AAA9RUN1-1|A0AAA9T6W7_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=1 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22090275, "end_pos": 22068745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128839.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128839.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074785.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074785.1" } ] } }, { "isoform_ac": "A0AAA9SI59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0AAA9SI59-1", "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISVLALA", "length": 580, "header": "tr|A0AAA9SI59-1|A0AAA9T6W7_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=1 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22090275, "end_pos": 22068745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103502.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103502.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085920.1" } ] } }, { "isoform_ac": "A0AAA9T6W7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0AAA9T6W7-1", "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISAMAQRLRKLDFPVKDSEEPSTPGPDKNHFLRPREPGEDTGKAQRDRVARVASEEAVEADQFRGPGAAKVSPEQTPPLLTGPMLSKDPTYCLKGEQM", "length": 798, "header": "tr|A0AAA9T6W7-1|A0AAA9T6W7_BOVIN Isoform 1 of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=1 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22090275, "end_pos": 22055555, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092335.1" } ] } }, { "isoform_ac": "A0AAA9TG74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#A0AAA9TG74-1", "sequence": { "sequence": "MQVGSRRLQISTSKMNPCPCFFRLGKGHGGSFRLLSPPVFWSSDLQLRKRGPGRGLHPLCRNSVPRLRLPPSSGLSPAYQGAGRGQGVGRGQGAQRAAESRRRRKNMAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISVLALA", "length": 707, "header": "tr|A0AAA9TG74-1|A0AAA9TG74_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=1 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22090275, "end_pos": 22068745, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134595.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134595.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095176.1" } ] } }, { "isoform_ac": "F1MQN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6W7/entry#F1MQN0-1", "sequence": { "sequence": "MAGAAGPATGSGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLASGDWFTSRTSACGLFSVCYPRASVAVKGEIRQYFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDIEALVMPTLRQAAEDKSWRVRYMVADKFSELQKAVGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELCENLPMEGRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTDALQEEVKPVLQKLGQDEDMDVKYFAQEAISAMAQRLRKLDFPVKDSEEPSTPGPDKNHFLRPREPGEDTGKLACPGAGGTRAPPPAAETLAWLPLCV", "length": 663, "header": "tr|F1MQN0-1|F1MQN0_BOVIN Computationally mapped isoform of Protein phosphatase 2 scaffold subunit Abeta OS=Bos taurus OX=9913 GN=PPP2R1B PE=3 SV=4 CANONICAL=A0AAA9T6W7-1" }, "locus": { "chromosome": "15", "start_pos": 22089957, "end_pos": 22058031, "strand": "+", "evidence": [ { "database": "Ensembl 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"https://www.uniprot.org/uniprotkb/A0AAA9S7V6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S843", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S843", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S843-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S843-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T768-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E601", "url": "https://www.uniprot.org/uniprotkb/G5E601", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E601-1", "url": "https://www.uniprot.org/uniprotkb/G5E601-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPFYSQEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1396, "header": "tr|A0AAA9T768-1|A0AAA9T768_BOVIN Isoform 1 of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0A3Q1LTV4-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMGMCWNTSSAK", "length": 1351, "header": "tr|A0A3Q1LTV4-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=2 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23623808, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074587.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074587.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060780.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060780.2" } ] } }, { "isoform_ac": "A0A3Q1LZV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0A3Q1LZV2-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1365, "header": "tr|A0A3Q1LZV2-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=2 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077460.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077460.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061261.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061261.2" } ] } }, { "isoform_ac": "A0AAA9S7V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0AAA9S7V6-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1380, "header": "tr|A0AAA9S7V6-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082116.1" } ] } }, { "isoform_ac": "A0AAA9S843-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0AAA9S843-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1344, "header": "tr|A0AAA9S843-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113250.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113250.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079503.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079503.1" } ] } }, { "isoform_ac": "A0AAA9SS50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0AAA9SS50-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1359, "header": "tr|A0AAA9SS50-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106151.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106151.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089213.1" } ] } }, { "isoform_ac": "A0AAA9T4J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0AAA9T4J6-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1358, "header": "tr|A0AAA9T4J6-1|A0AAA9T768_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100627.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100627.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091431.1" } ] } }, { "isoform_ac": "A0AAA9T768-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#A0AAA9T768-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPFYSQEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1396, "header": "tr|A0AAA9T768-1|A0AAA9T768_BOVIN Isoform 1 of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=1 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133553.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133553.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091667.1" } ] } }, { "isoform_ac": "G5E601-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768/entry#G5E601-1", "sequence": { "sequence": "MACSIVQFCSFQDLQAARDFLFPHLREETPSGAVRRDPSKSNWEDDGWGAWEESEPQEPEEEGNTCKPQKTCWLQDCILSLSPTNDLMVIAREQKAVFLVPKWKHSDKGKEEMQFAVGWSGSLSVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLLNEDSVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGYNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEAFQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQTGWIQIVEDLHERVPEKGDFSPFGSPQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKYCRLLYPGYKIMGLNNITSQSWQPQTYQICLVDPVSGSVKTVSVPFHLALSDKKSERAKDMHLVKKLGTLLKAKCPNLDLIETEIKELILDIKYPATKKQALESILASERLPFSCLKNITQTLMDTLKNQELESVDEGLLQFCANKLKLLHLYESVSQLNSTDFHSDTPFSDNDLAVLLRLDEKELLKLQALLEKYKQENNRTAVRFSDDKDGVLPVKTFLEYLEYEKDVVNIKKTSEEEYVALGSFFFWKCLCGESSTEEMCHTLESAGLSPQLLLSLLLSVWLSKEKDILDKPQSVCCLHTMLYLLSKMKVAIEETWDSQSVSPWWQQMRTVCIQSENNGAALLSAHVGHAVAAQISNSLTEKKFSQTVSGTDSEALTDSWEALSLDTEYWKLLLKQLEDCLLLQTLLHSKTNTRTSKVSSLQAEPLPKLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLANKGRDAENPDEPREGINRGLFEVSEVEMDLGAIPDLLHLAYKQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFFVRSIEHLKHILNAHIQNGIALMMWNTFLVKRFSAATYLMDKVGKAPKDRLCRRDVGMSDTAVTSFLGCCWDLLQTLMEADVSRDEMQVPVLDTEDAWLTVEGPVSIVELALDQKHIHYPLVVHHSVLGAILYAVMRFSLKTVKPLSLFDSKFLLKVVSAAVQARHTVAKDRDSTEEAATAPFGKDQDWPVLAVDLAHHLQVNEDVVRRHYVGELYNYGADHLGEEAILQVQDKEVLASQLLVLIGQRLAHAVLRTQTREGLELLARLPPTLCTWLKAMNPQDLQNTEVPIATTAKLVNKVIELLPENHGQYSLALHLTEAVEAISLPPL", "length": 1362, "header": "tr|G5E601-1|G5E601_BOVIN Computationally mapped isoform of RAB3 GTPase activating non-catalytic protein subunit 2 OS=Bos taurus OX=9913 GN=RAB3GAP2 PE=3 SV=2 CANONICAL=A0AAA9T768-1" }, "locus": { "chromosome": "16", "start_pos": 23735418, "end_pos": 23634325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047860.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047860.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045024.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045024.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" }, { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "establishment of protein localization to endoplasmic reticulum membrane", "id": "GO:0097051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "positive regulation of endoplasmic reticulum tubular network organization", "id": "GO:1903373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903373", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" }, { "name": "synaptic signaling", "id": "GO:0099536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099536", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T768", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 614, "end_pos": 616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 656, "end_pos": 658, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" }, { "id": "PF14655", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14655" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab3-GAP regulatory subunit N-terminal", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 501, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T768", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T768" }, { "id": "PF14656", 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"strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011068", "url": "https://www.ensembl.org/id/ENSBTAG00000011068" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011068", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011068", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782635", "url": "https://www.ncbi.nlm.nih.gov/gene/782635", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR015403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782635", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782635", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWRLCLN", "url": "https://omabrowser.org/oma/group/AWRLCLN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0W2", "url": "https://www.orthodb.org/?gene=A0A3Q1M0W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEQ1", "url": "https://www.orthodb.org/?gene=A0A3Q1MEQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPI7", "url": "https://www.orthodb.org/?gene=E1BPI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663:SF333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12783", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16206", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16206", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M0W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0W2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEQ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S793", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S793", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S793-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S793-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TX34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPI7", "url": "https://www.uniprot.org/uniprotkb/E1BPI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPI7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEKVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1721, "header": "tr|A0AAA9T6Y7-1|A0AAA9T6Y7_BOVIN Isoform 1 of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0A3Q1M0W2-1", "sequence": { "sequence": "MSGTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1649, "header": "tr|A0A3Q1M0W2-1|A0AAA9T6Y7_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51105269, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066877.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066877.1" } ] } }, { "isoform_ac": "A0A3Q1MEQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0A3Q1MEQ1-1", "sequence": { "sequence": "MSTRLRFEVAVHEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1690, "header": "tr|A0A3Q1MEQ1-1|A0AAA9T6Y7_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51092319, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086358.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086358.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068989.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068989.1" } ] } }, { "isoform_ac": "A0AAA9S793-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0AAA9S793-1", "sequence": { "sequence": "MQEEIPTGQGALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1666, "header": "tr|A0AAA9S793-1|A0AAA9T6Y7_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51105189, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115243.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115243.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079178.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079178.1" } ] } }, { "isoform_ac": "A0AAA9SZZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0AAA9SZZ2-1", "sequence": { "sequence": "MSGTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1720, "header": "tr|A0AAA9SZZ2-1|A0AAA9T6Y7_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51105269, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120270.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120270.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089698.1" } ] } }, { "isoform_ac": "A0AAA9T6Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0AAA9T6Y7-1", "sequence": { "sequence": "MSGTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEKVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1721, "header": "tr|A0AAA9T6Y7-1|A0AAA9T6Y7_BOVIN Isoform 1 of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51105269, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125570.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125570.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094533.1" } ] } }, { "isoform_ac": "A0AAA9TX34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#A0AAA9TX34-1", "sequence": { "sequence": "MGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1642, "header": "tr|A0AAA9TX34-1|A0AAA9TX34_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=1 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51080480, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127592.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127592.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103207.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103207.1" } ] } }, { "isoform_ac": "E1BPI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7/entry#E1BPI7-1", "sequence": { "sequence": "MSGTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDITDQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPAATNQAGNNNSGGPVSAPANSGMLGIGGGVTLLPAFEYRGTWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITNMIEGELGEVETECQTTTTEAVSSPTQSSEQQELQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPAVNVPAPVLLGPISGPSLNRPFVRTDSIGERLGRYSSSEPPVVTDELEDLNLWWAAWNTWYRIGSESTKPPITLDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHRAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQAEWVALNYVPFAERSLDVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTKPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPTSKVQNGES", "length": 1714, "header": "tr|E1BPI7-1|A0AAA9T6Y7_BOVIN Computationally mapped isoform of Protein MON2 homolog OS=Bos taurus OX=9913 GN=MON2 PE=3 SV=4 CANONICAL=A0AAA9T6Y7-1" }, "locus": { "chromosome": "5", "start_pos": 51105269, "end_pos": 50995059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014698.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014698.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014698.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014698.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782635", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782635", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YIJ1-1", "protein_name": "Protein MON2 homolog", "gene_name": "MON2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGTSSPEAVKKLLENMQGDLRGLSLECRKKFPPVKEAAESGIIKVKTIAARNTDILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSEAAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERVVAEDERYKDIIEQPVAVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPSAGNTSVTPNQTGSNASGSTGSAQTNPGVLGMGGGATVLPAFEYRGTWIPILNVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITTMIEGELGEAETVSQSTTETTSLPALSSEHQDSQSISDQSDKELVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNSTTAALSSKSYSIQGQNVQMISPSSESHQQVVAVGQPLALQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPGVGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEKVCQHPNSRMREWGAEALTSLIKAGLTFSHDPPLSQNQRLQLLLLNPLKELSNISHPDIRIKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRSDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVEVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGEIIEKELNKEEAVLQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSQAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSEKPDTPPAINVSVPVVVGATTATSLGRSFMRTDSIGERMGRYNGAELPVVTDEIEDLNLWWAAWNSWYRIGSESTKPPITCDKLTFIPSQPFLTALIQIFPALYQHIKTGFSMDDLQKLGIILHGAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGSENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRIPLSLKYSCPSESTWKLAVSSLLKVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSAPPDNLSIQEFQKNESIDVEVVQLISTEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKVCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDANTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMHPPASKVQNGES", "length": 1720 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F4K5S0-1", "protein_name": "ARM repeat superfamily protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALVAALEADLRALSAEARRRYPAVKDGAEHAILKLRSSSSASDLSSNEDILRIFLMACGVRNTKLSVIGLSCLQKLISHDAVEPSSLKEILYTLKDHSEMAEENIQLKTLQTILIIFQSRLHPETEDNMVLGLSICLTLLDNNRPPSVYNTAAATFRQAVALIFDQVVSAESLPMPKFGSSSQTARTGSVTGDLSQNINNSGPLEKDVIGGRLTIRDTLSETGKLGLRLLEDLTASAAGGSAAWLHVTSLPRTFSLELIEFVLSNYISVFKILLPYEQVLRHQICSLLMTSLRTSSELEGEMVEPYFRRLVLRSVAHIIRLYSSSLITECEVFLSMLVKATFLDLPLWHRILVLEILRGFCVEARTLRILFQNFDMKLPSRSFFTLQLKKHPKNTNVVESMVKALARVVSSIQFQETSEESLAAVAGMFSSKAKGIEWILDNDASSAAVLVASEAHAITLAIEGLLGVVFTVATLTDEAVDVGELESPRYEHLPSSDYTGKTSLLCISMVDSLWLTILDAFSLILSRSQGEAIVLEILKGYQAFTQACGVLHAVEPLNSFLASLCKFTIVLPTDVERKSSVVQSPVSKRSEVQVDLKDVIVLTPKNVQALRTLFNIAHRLHNVLGPSWVLVLETLAALDRAIHSPHATTQEVATAVPKLTREPSRQYADFSILSSLNSQLFESSALMQVSSVKSLLSALHMLSHQSMTETSGSVSSASSKQIGSISFSVDRMISILVNNLHRVEPLWDQVVGHFLELAEHSNQNLRNMALDALDQSICAVLGSEQFGEDPARSRDATLDVDSKSTEVKSVECAVLSSLRVLYFSAQKADVRVGSLKILLHVLERCGEKLYYSWSSILEMLRSVADASEKDVATLGFQSLRVIMSDGLPTLPEDCLHVCIDVTGAYSAQKTDLNISLTAIGLLWTLTDFVAKGLHHGSLVEKGSGFNNADSTPQQTNGEDGEKHMGSNSGKSDYEAPIQVVNHEKLLFLVFSLIQKLVDDERPEVRNSAVRTFFQILGSHGNKLSKSMWEDCLWNYIFPMLDGASHKAATSSKDEWQGKEIGTRGGKAVHMLIHHSRNSAQKQWDETFVLVLGGIARLFRSYFPLLESLPNFWSGWESLLAFVKKSIFNGSKEVSLAAINCLQTAVVSHCVKGNLQLRYLNSVLDVYELVFQKSSSYTGDTAAKVKQEILHGLGELYVQSSKMFDDKMYMQLLGIVDLAIKQAIINSENFETEYGHVPPVLRHVLEILPSLGPPEHLSSMWLILLREFLHYLPRVDSVLPNDEGSEVLEQKADASSETIPTTRITTNMFAEKLIPALIELLLQAPAVEKYILFPEVIQNLRRCMMTRRDNPDGSLWKVAAEGFNRLLVEDVKLCSVGGETELKISKTARIRIWKEIGDVYDIFLVGYCGRALSSNSLPAATLKANETLEIALLNGLGDIILKSTVDAPREVLERLVSTLDRCASRTCSLPVETVELMPAHCSRFSLTCLQKLFSLSSFSSETENWHSTRAEVSKISITTLMARCEFILSRFLIDENNLGNRPIPTARLEEIIFTLQELYRLSIHPEVASVLPLQPYLKNVLREDNRDTRAHLLVLFPSLCEIVLSREMRVRELVQILLRAVATELGLEKRVLNYSVCCILQYAILRDFMLVWFNKVLC", "length": 1658 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P48563-1", "protein_name": "Protein MON2", "gene_name": "MON2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAMNTGGFDSMQRQLEAELRSLSSESKRRNSTIRHASDKSIEILKRVHSFEELERHPDFALPFVLACQSRNAKMTTLAMQCLQGLSTVPSIPRSRLSEILDAFIEATHLAMEIQLKVLQVVPIFFKTYGKFIYGPLCKKLLLCCSNLLHVPNKAPVVVGTASATLQQLIDEIFDRLSIESVVDDKQYEVLISNSESIKVNVYRYDANKLFDNICSLNEISSNGAVSDEEMLLDIGDIPIDYGLEILESILKNSQKNLLECQDLQYLLRVKAIPLLLRCISSSRHFSTAVRSCRCLKLLIRKEYLSILELELEVILSLLIHGISVESNLSGWQRVLSLELFKDLSQDPEIVNTLYMDYDNYPDKKHVFKYLLKECIVLLNSPEYITFLAPSKVVEKMDSPLITTENSTVKTKFMHLLDKSNAPSINITYIISLILTICNHLCEGLNKSALESSPLEKKIEDKEREEGTGNDSTVVKVYSGLFSGLFELNKLFLYSTSLETSIFHLVVRAFQKLAHSAGVLSLKDKLRACMKLFSILITNNVTSSNQYSFNDTSKSAKNQHTRNISTSSVTTSPVESTKNPSRSIADSAQNKEMKRRLHPRNISSRQVSLLRALISLSISLGPIFDSESWRYTFLTWQWITYYIYGPSADFKESFYSEDIPPPPILTKSDVTSIESSLTKFFESTSSYSCSTFHLVLTRLILDSKNTLTLEQTNLNLNNDIGYHPLDAKDEIIPCIYNKAFFVNKIGELATYNCKKFLFGKNGKELWSLISTYMIKLISNREMDNDSLRLYTVRVFTDIIKKATNEVGNSDEQDNKVKQFGTLENLVIDSLMATINSIKQLDIGKQEIYNGTINVESDILFQLLLTLKEILNEFGELLMNSWTNIFNIINSPFEWTVEDTDFSVNEDIDDSSLFEGIVQKHKNMIQVSYDVFKLISDDFLQSLPMSVIKFVIDTLVNFVSQKRNLNISFSSISQFWLVGDYLRVRFNPETLNLSDEKRRSLSEKINNQKLIEIITSSSSHDWELYNGLWIYLLKNLINCTNDDRVEVKNGAVQTFFRIIDSHSVCFPPWDLIFLEVIEPLLTKEWSTEELENETDFINVTLQGLIKLYPEHFKDFKNNTTCAKEWSMLLDFLKRLLSSTSNNTKNAVILNYQTLLKEIITIEDVPSDILKKCCEIFTDYNITYSDLSTNASSKTEYDCIYELITGFPPLYQLISKYDAMTDEFVEKVLLLFNSAIKYPLLPEFVQDKTKPSSMQKAILSGLDIFMTNDSKDTEILILLQLSTISILAFDTREKITKKLGPKLPKASLNRLPTFEAISYMSCSNLRNRIAKIDQFGISTLKAKHILRILKNLAEIIKRKSLITGSESDEIPIWVLASNCFCDLSNKIFKSLQEDAENPLKDNFCDLFINVIVVTLQRINPELDNLTEIDDLNEYSKYREILLENRIIDLFNERQLDTFIYAVWDCSFLYEFDELENALMQDCGTFSELSQKLSSFDFSCIFGSTTNPRFQTKYKCSLECLQDLVNFMLNTNEKLRKLTAPYLSARIALALRRYISDEYLIGRAPIPKLRKTELATLLNGLCVILRGVLDQNSTLGNKQIGVENLQTLSPLILRTIPVSHKMDGLQDKVLELSLGFTKLD", "length": 1636 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q55BA7-1", "protein_name": "Protein MON2 homolog", "gene_name": "mon2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKNKSALLSFLEMDLRNISSEARNKLLNIKEASERGILYIKYLQEQSATPEILLQNLKSKSDEILKPFLMALESKNQKMISLAIGSVLKLISHSAISNSSIPSILSKMQLLIDVGSDESIQLKVLQGLLVLITTVPDIHDEELSQLLVLCFRLHGSKNTSIQSTSSATLPQIIRIIFDRVSVEMNTANKEILSSPVTTKLINSKSSDNITLSNNNNQDDSSSSSLSTTSDSTTTTKNDDNTGTTTPTTTTTENTDTKTTTTVTETTDTKTTTATDNQSPQLKSSPSNTNVVQQHQQHNKNKSWSNLKPSAKDAYLLLQDLCYITGSDSPEWLPHTTTISRASGLDFIEMILSVHYDIFFKLEEFKNLLKDKICPLLIKNFKFKMDFYHTVRLIRVITQFISKFSSIMVTESDVLLTKTIKMMDLDQPIWTQILALESFRVYSEDPNLLRLFFKNYDKDNNSAKIFETMTIAIGKYVQNLYGLDSSHFVLVQTSKNRLLDLLWQSEVPLIKESYIISVCTECINGIVNAVSKINNPDNSAQQYSDSLEIFTQMANSCWVSILGGISMLLGKTNDEALIQMVLKSLQSFTNTCGDLHLSAPRDALLTCLCKTTTLPSFELLNSNLNLNATTTTTTTTNTNTINNINNINNINNTNNTNNSNNINNTNINTNNINNSEQQQQQQQQQIQSPISSTSTSSNIISSQQSTPSNSLTPQQLSQNNKDGQISINTMEEKLSNFYPTTKNILSVKILFNIAHCMGSLLDESWILVLETLETWNRFLESFLKKKENSNNTQTTTGTGNTINGNNNNNSGGNKSGDNIILPNPSSLSIANNNNINNNNENTSSPKETSSPRTIGSSEVPILMNSMDNLFKSSSQLDLRSCQYLLEALGKLCTQSFNLKSFNSTPNMFGISKLRETALANLYRIDTIWPLISDHIIDAGNHRNPLFRKYSVEFLNSIIKSTISLQQSQQLLQLQKEKLLSQQQQQQQEKEKEKDNSSLNSESNEDQSSDLTNSPVSTTTTTTTTTTTTTTSTINILNSNLSSINSQFIENYEFEKELLELDKNQIQLEFFTTLEELSFSTSNDTKEKVLESINSILSTSGQSLTTSWPIILSILLRMSKCNEKRFISLSFSSLELICNEFLSNLTPECLALTIELIESFVSQKADINISLTGSSGLLTDLTYFLANENSIKTSKYQVSDGKAIDPVKESHSQCRFTKTLNSRIRPSISESSPFFKEKNKSLIDRMWLCSFNSMKTLCIDVRPAIRNGVVVSLFQILTTYFHLFEKELLDVILWSILFPLIQEIKSFSEKADQERIDSDLGGGVMLLVHHSRNTAQKQWDETQVLSIGGMVRIFKTFFDQLFTLPTFDAAWSTLLNHLQTESKSSSKEVSLTSLSFIHEIVNTPSIIDPSHPQLAESIWECLLHLSPKLFDPQNSVPKSLSVYIKVFTDLFNKTRPQLNHAQMNRALEIIFPMGLFIGDSSTVLSNPQTHAIQLIKSLPPITVDIFPSVISILLKYISIGINMVSPPFTPTSATCDFIFPPQTPITKDLVYYSTITEQSIDLIYELFSHSSTTDEMRSLVFEDIIKVLGASMLTKYQKYHSTIWKLSVSNLIKLLPSGLLAINIDSNHLNDIKRNIIWTELIDSIQTFILHERPNHQISPEKRLEEDQYDIDLINAISKEMVGFSGIKVERVSIIRDRLVEILQEGSVLSAHGREKVAQSCYRNMFSICSTTNNNNNNNNKNDNNNNNNTDDNDGNQASESIEIAKVVLPVVLKRCKDVLTRFVIDERQSGNYPLPRYRLSEISFILKEIYELQLQSGVYQPLNNSTTIIKPECKRPHLLELYTILCDCICTSEKEIKELLKNIFLIISKEFLNL", "length": 1874 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7Z3U7-1", "protein_name": "Protein MON2 homolog", "gene_name": "MON2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGTSSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDERHRDIIEQPVLVQGNSNRRSVSTLKPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPATSNQAGNNNLGGSVSAPANSGMVGIGGGVTLLPAFEYRGTWIPILTITVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITSMIEGELGELETECQTTTEEGSSPTQSTEQQDLQSTSDQMDKEIVSRAVWEEMVNACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNTTTAATLSNKSYSVQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGLTFNHDPPLSQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCTCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVVLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSDKPETPPVVNVPVPVLIGPISGMSRPFVRTDSIGEKLGRYSSSEPPIVTDELEDLNLWWAAWNTWYRIGSESTKPPITFDKLTFIPSQPFLTALIQIFPALYQHIKTGFNMDDLQKLGVILHSAISVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVSSLLRVLSIGLPVARQHASSGKFDSMWPELANTFEDFLFTKSIPPDNLSIQEFQRNENIDVEVVQLISNEILPYANFIPKEFVGQIMTMLNKGSIHSQSSSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWAQVIALYPTLVECITCSSSEVCSALKEALVPFKDFMQPPASRVQNGES", "length": 1717 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80TL7-1", "protein_name": "Protein MON2 homolog", "gene_name": "Mon2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCTNSPEAVKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTTNTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDDRHRDIEPPVPIQGNSNRRSVSTLRPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFLLKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVTECEIFLSLLVKFLDSDKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDIVNALGSFIQSLFLVPPTGNPATANQAGNNNAGGPASAPANSGVVGVGGGVTLLPAFEYRGAWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITTMIEGELGEVEAEGPSVTEGASSQSSERRDEQAASDPMDQETVSRAVWEEMVSACWCGLLAALSLLLDASTDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNATTAATLSNKSYSIQGQSVMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLVLATLQHLVWILGLKPSSGGALKPGRAVEGPSTVLTTAVMTDLPVISNILSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLTGHLLEKVCQHPNSRMREWGAEALTSLIRAGLTFSHEPPLPQNQRLQLLLLNPLKEMSNINHPDIRLKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCSCLQIVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVSLNRPFHPAPPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLGDFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSEKPEPPAVSVPVPVLLGNLSGPGLSRPFVRTDSIGEKLGRCGSETPVVTDELEDLKLWWAAWNTWHRTGSESTEPPSSVDELTFIPSQPFLTALVQIFPALYQHIKAGFSMADLQKLGVILHSAVSVPISSDASPFILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQLETKHIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIKTLRVPLSLKYSCPSESTWKLAVASLLKVLSIGLPVARQHASSGKFDSMWPELASTLEDFLFTKSIPPDNLSIQEFQRNESIDVEVVQLISAEILPYANLIPKAFVGQMMTMLNKGSIHSQPCSFTEAEIDIRLREEFSKMCFETLLQFSFSNKVTTPQEGYISRMALSVLLKRSQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWSQVIALYPTLVECITCSSSDVGSALKEALAPFKDFMQPPASRVQNGES", "length": 1715 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VLT1-1", "protein_name": "Protein MON2 homolog", "gene_name": "mon2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFVGGGGCGGQDVHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSSQQNSVYYTVNQILYPLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTTNTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSPAEGEGGNQDVQTFASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAVFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQKYHTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHDMIAAMGSYIRYSLINASAMLNGQQNGVANSLTAMSGSNQCGFMFRGAYLPLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAVITEEEHKPLCLQLVNSSWSALLSAFIPLVETSIDEATTENILKAMQNYAALCGMLEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHNNGGILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAMPKPAVEANVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCKLSHEAMELAYANREPSLFAVAKLLETGLVNMPRIKVLWRPLTNHLLEVCQHRHIRMREWGVEAITYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVRQRQLDCVLQILNTAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQTQELNISLTAIGLMWNISDFFNQNQDKLMSTQLQDVSILPDFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDASGNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLGDFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMYHNTAERTERALKDPQTAQEQDEEIWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFLTALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAKSSGHYANNASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTWKLAISSLISVLHTGLKVARAKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETIDCQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNICYESDWKLREIFAKTCFETLLQFSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQYTDLLQAPRSCSAATSNDNVIQSNGQE", "length": 1684 }, "evidence": [ { "id": "A0AAA9T6Y7", "url": "https://omabrowser.org/oma/group/A0AAA9T6Y7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" }, { "name": "protein targeting to vacuole", "id": "GO:0006623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1514, "end_pos": 1516, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1523, "end_pos": 1525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 965, "end_pos": 967, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" }, { "id": "PF16206", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16206" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mon2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 936, "end_pos": 1712, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T6Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Y7" }, { "id": "PF09324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mon2/Sec7/BIG1-like HDS", "eco_id": "ECO_0000259", "start_pos": 853, 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"name": "leucine-rich repeat and calponin homology domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_024844305", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844305" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRCH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806", "locus": { "chromosome": "X", "start_pos": 63643323, "end_pos": 63745866, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050382", "url": "https://www.ensembl.org/id/ENSBTAG00000050382" } ] } } ], "crossref": [ { "id": "A0AAA9T806", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T806", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050382", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050382", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21271", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21271", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100336559", "url": "https://www.ncbi.nlm.nih.gov/gene/100336559", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336559", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336559", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844305", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844305", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Y9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T806", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T806-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASQGGGGNSGGGGCGGGGSSGGGGGAGGGGGGAGVGGGGGGGGTMVVPIPVPTLFGQPFPNGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYHNCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHSTGSKPDSQKDQEVYDFTDANTNDVVVPEQGDAHIGSFVAFLKGKEKGPEKSQKNEELGDAKRLGKEQLLTEEEDDGLKEVTDLRKIAVQLLQQEQKNRILNHSTYVIRNKPKQTMECEKSVSADEVNSPLSPLIWQPLENQKDQTDGQQWPESHPIIWQSEERRRSKQIRKEYLKYKSSRKSSSGNENNEQDSDNANISPQSPVSSEEYDRTDVFSHGPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSTA", "length": 766, "header": "tr|A0AAA9T806-1|A0AAA9T806_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 2 OS=Bos taurus OX=9913 GN=LRCH2 PE=4 SV=1 CANONICAL=A0AAA9T806-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806/entry#A0A3Q1MFC9-1", "sequence": { "sequence": "MVVPIPVPTLFGQPFPNGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYHNCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHSTGSKPDSQKACKAPLSVGFSRQEYWSGLPCSPPGDLPDPGIEPTSLASPALADQEVYDFTDANTNDVVVPEQGDAHIGSFVAFLKGKEKGPEKSQKNEELGDAKRLGKEQLLTEEEDDGLKEVTDLRKIAVQLLQQEQKNRILNHSTYVIRNKPKQTMECEKSVSADEVNSPLSPLIWQPLENQKDQTDGQQWPESHPIIWQSEERRRSKQIRKEYLKYKSSRKSSSGNENNEQDSDNANISPQSPVSSEEYDRTDVFSHGPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSTA", "length": 763, "header": "tr|A0A3Q1MFC9-1|A0AAA9T806_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 2 OS=Bos taurus OX=9913 GN=LRCH2 PE=4 SV=2 CANONICAL=A0AAA9T806-1" }, "locus": { "chromosome": "X", "start_pos": 63745695, "end_pos": 63644327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078187.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078187.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069231.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069231.2" } ] } }, { "isoform_ac": "A0AAA9S3Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806/entry#A0AAA9S3Y9-1", "sequence": { "sequence": "MAASQGGGGNSGGGGCGGGGSSGGGGGAGGGGGGAGVGGGGGGGGTMVVPIPVPTLFGQPFPNGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYHNCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHSTGSKPDSQKDQEVYDFTDANTNDVVVPEQGDAHIGSFVAFLKGKEKGPEKSQKNEELGDAKRLGKEQLLTEEEDDGLKEVTDLRKIAVQLLQQEQKNRILNHSTYVIRNKPKQTMECEKSVSADEVNSPLSPLIWQPLENQKDQTDGQQWPESHPIIWQSEERRRSKQIRKEYLKYKSSRKSSSGNENNEEYDRTDVFSHGPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSTA", "length": 749, "header": "tr|A0AAA9S3Y9-1|A0AAA9T806_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 2 OS=Bos taurus OX=9913 GN=LRCH2 PE=4 SV=1 CANONICAL=A0AAA9T806-1" }, "locus": { "chromosome": "X", "start_pos": 63745833, "end_pos": 63644327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105037.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105037.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078513.1" } ] } }, { "isoform_ac": "A0AAA9SGH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806/entry#A0AAA9SGH4-1", "sequence": { "sequence": "MAASQGGGGAGVGGGGGGGGTMVVPIPVPTLFGQPFPNGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYHNCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHSTGSKPDSQKDQEVYDFTDANTNDVVVPEQGDAHIGSFVAFLKGKEKGPEKSQKNEELGDAKRLGKEQLLTEEEDDGLKEVTDLRKIAVQLLQQEQKNRILNHSTYVIRNKPKQTMECEKSVSADEVNSPLSPLIWQPLENQKDQTDGQQWPESHPIIWQSEERRRSKQIRKEYLKYKSSRKSSSGNENNEQDSDNANISPQSPVSSEEYDRTDVFSHGPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSTA", "length": 741, "header": "tr|A0AAA9SGH4-1|A0AAA9T806_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 2 OS=Bos taurus OX=9913 GN=LRCH2 PE=4 SV=1 CANONICAL=A0AAA9T806-1" }, "locus": { "chromosome": "X", "start_pos": 63745833, "end_pos": 63644327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091981.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091981.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084461.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084461.1" } ] } }, { "isoform_ac": "A0AAA9T806-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806/entry#A0AAA9T806-1", "sequence": { "sequence": "MAASQGGGGNSGGGGCGGGGSSGGGGGAGGGGGGAGVGGGGGGGGTMVVPIPVPTLFGQPFPNGPQWNPGSLQPQHTVRSLDRALEEAGNSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSEVWLFAPLETLNLYHNCIKIIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVLSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLQSLRELNIRRNNLQALPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTISLHSQVSESNREQTSRNDSHSTGSKPDSQKDQEVYDFTDANTNDVVVPEQGDAHIGSFVAFLKGKEKGPEKSQKNEELGDAKRLGKEQLLTEEEDDGLKEVTDLRKIAVQLLQQEQKNRILNHSTYVIRNKPKQTMECEKSVSADEVNSPLSPLIWQPLENQKDQTDGQQWPESHPIIWQSEERRRSKQIRKEYLKYKSSRKSSSGNENNEQDSDNANISPQSPVSSEEYDRTDVFSHGPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSTA", "length": 766, "header": "tr|A0AAA9T806-1|A0AAA9T806_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 2 OS=Bos taurus OX=9913 GN=LRCH2 PE=4 SV=1 CANONICAL=A0AAA9T806-1" }, "locus": { "chromosome": "X", "start_pos": 63745833, "end_pos": 63644327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093156.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093156.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091981.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336559", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336559", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 492, "end_pos": 494, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T806" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 643, "end_pos": 756, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 164, "end_pos": 166 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 492, "end_pos": 494 }, { "start_pos": 588, "end_pos": 590 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6E4-1", "uniprot_ac": "A0AAA9T6E4", "uniprot_id": "A0AAA9T6E4_BOVIN", "mass": { "chemical_mass": 72167.0, "monoisotopic_mass": 72167.0 }, "refseq": { "ac": "XP_005222505", "name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222505" }, "gene_names": [ { "name": "MTMR14", "type": "recommended", "evidence": [ { "id": "A0AAA9T6E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ] }, { "name": "MTMR14", "type": "synonym", "evidence": [ { "id": "XP_005222505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222505" } ] }, { "name": "jumpy", "type": "synonym", "evidence": [ { "id": "XP_005222505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222505" } ] } ], "protein_names": [ { "name": "Myotubularin related protein 14", "type": "synonym", "evidence": [ { "id": "A0AAA9T6E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4/entry#names_and_taxonomy" } ] }, { "name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005222505", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222505" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTMR14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4", "locus": { "chromosome": "22", "start_pos": 17006958, "end_pos": 17052084, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009765", "url": "https://www.ensembl.org/id/ENSBTAG00000009765" } ] } } ], "crossref": [ { "id": "A0AAA9T6E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009765", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009765", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13213", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13213", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514596", "url": "https://www.ncbi.nlm.nih.gov/gene/514596", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039803", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039803", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CALKTHR", "url": "https://omabrowser.org/oma/group/CALKTHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHG0", "url": "https://www.orthodb.org/?gene=A0A3Q1MHG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13524", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13524", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13524:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13524:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_005222505", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222505", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGARAAAAASAGSSASSGSPQPQEPGLGELLEEFSRTQYRAKDCSGTGGSKVERIEKRCLELFGRDYCYSVIQNVNGDICGHYPQHIVFLEYESSEKEKDTFQSTVQVSKLQDLVNRSKTARCRGRFVCPVILFKGKHICRSATLAGWGELYGRTGYNYIFSGGADDAWADAEDLTEEDCALRSSDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTCSLNIDWSQYQSWDLVQQTQNYLKLLLSIINNDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHIISEEFSALKTQRRKSLPARDAGFTVEDICMLRRKDRGSTTSLGSDFSLVMESSPGAAGSFTYETVELVPAGSQTQAAWRKSHSSSPQSMLWNRPQPSEDRLPPHQGLVEAKSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNNCLLTALSERETRLQEVRSAFLAAYSSTVGLRAAAPSPSGAIGGLLEQFVRGVGLRGTSSSTL", "length": 649, "header": "tr|A0AAA9T6E4-1|A0AAA9T6E4_BOVIN Isoform 1 of Myotubularin related protein 14 OS=Bos taurus OX=9913 GN=MTMR14 PE=4 SV=1 CANONICAL=A0AAA9T6E4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4/entry#A0A3Q1MHG0-1", "sequence": { "sequence": "MAGARAAAAASAGSSASSGSPQPQEPGLGELLEEFSRTQYRAKDCSGTGGSKVERIEKRCLELFGRDYCYSVIQNVNGDICGHYPQHIVFLEYESSEKEKDTFQSTVQVSKLQDLVNRSKTARCRGRFVCPVILFKGKHICRSATLAGWGELYGRTGYNYIFSGGADDAWADAEDLTEEDCALRSSDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQSWDLVQQTQNYLKLLLSIINNDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHIISEEFSALKTQRRKSLPARDAGFTVEDICMLRRKDRGSTTSLGSDFSLVMESSPGAAGSFTYETVELVPAGSQTQAAWRKSHSSSPQSMLWNRPQPSEDRLPPHQGLVEAKSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNNCLLTALSERETRLQEVRSAFLAAYSSTVGLRAAAPSPSGAIGGLLEQFVRGVGLRGTSSSTL", "length": 624, "header": "tr|A0A3Q1MHG0-1|A0AAA9T6E4_BOVIN Computationally mapped isoform of Myotubularin related protein 14 OS=Bos taurus OX=9913 GN=MTMR14 PE=4 SV=1 CANONICAL=A0AAA9T6E4-1" }, "locus": { "chromosome": "22", "start_pos": 17051984, "end_pos": 17007962, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081823.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081823.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070679.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070679.1" } ] } }, { "isoform_ac": "A0AAA9T6E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4/entry#A0AAA9T6E4-1", "sequence": { "sequence": "MAGARAAAAASAGSSASSGSPQPQEPGLGELLEEFSRTQYRAKDCSGTGGSKVERIEKRCLELFGRDYCYSVIQNVNGDICGHYPQHIVFLEYESSEKEKDTFQSTVQVSKLQDLVNRSKTARCRGRFVCPVILFKGKHICRSATLAGWGELYGRTGYNYIFSGGADDAWADAEDLTEEDCALRSSDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTCSLNIDWSQYQSWDLVQQTQNYLKLLLSIINNDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHIISEEFSALKTQRRKSLPARDAGFTVEDICMLRRKDRGSTTSLGSDFSLVMESSPGAAGSFTYETVELVPAGSQTQAAWRKSHSSSPQSMLWNRPQPSEDRLPPHQGLVEAKSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNNCLLTALSERETRLQEVRSAFLAAYSSTVGLRAAAPSPSGAIGGLLEQFVRGVGLRGTSSSTL", "length": 649, "header": "tr|A0AAA9T6E4-1|A0AAA9T6E4_BOVIN Isoform 1 of Myotubularin related protein 14 OS=Bos taurus OX=9913 GN=MTMR14 PE=4 SV=1 CANONICAL=A0AAA9T6E4-1" }, "locus": { "chromosome": "22", "start_pos": 17051984, "end_pos": 17007962, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092302.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZMA2-1", "protein_name": "Myotubularin related protein 14", "gene_name": "Mtmr14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGARAAAAASAGSTASSGSPPPQEPGLWELLEEFSRTQYRAKDSGGKSGSKVELIEKRCLELFGRDYCFSVIPNVNGDICGHYPRHIVFLEYESSEKEKDTFQSTVQVNKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYFFSGGADDTWANTEDVTEEDFVLRSGDTHLFDKVRGYDIKLLQYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYANFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLNIPDFLTQSLNIDWSQYQSWDLVQQTQNYLKLLLFIMNRDDDHGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFCLKTQRRKSLPTRDAGFTVEDICMLRHRDRGSTTSLGSDFSLVLEHSPGAVGSFSYEAVELVPAGAPTQAAWRKSHSSSPQSMLWSRPQPSDDRLPSHHGFTEAKSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVSGCGSIQERPVLHTDSSLPFSFQDELPNSCLLTALSDRETRLQEVRSAFLAAYSSTVRLRAAAPSPSGAIGGLLEQFARGVGLRGTSTSAL", "length": 648 }, "evidence": [ { "id": "A0AAA9T6E4", "url": "https://omabrowser.org/oma/group/A0AAA9T6E4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1P4J6-1", "protein_name": "Myotubularin related protein 14", "gene_name": "MTMR14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAARGCPPAGSGDRGLAELLLEFSRTQYRAKDGGGAAAAKVERIERRCLELFGRDYRYSVISNAHGEVCAHYPRHIVLLERDNAAGRDPFESTVQVGKLQDLINRSKMARCRGRFVCPVILYKGKHICRSATLAGWGELYGRTGYNYIFSGGSDDAWADAEDISEDDSALRNADSQLFDKVRGHDIKLLRYLSVRYICDLMVENKKVKFGLNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYTAEGLIFNWKQDYVDAPLSIPASVTQSLSIDWSEYQSWDLVQQTQNYLKLLISIINSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHASLEPSEILYLTVAYDWFLFGHMLVDRLNKGEEIFFFCFNFLKHITSEEFSAVKSQRRKSLPPGFTLEEICMLKQRDRGSTTSLSSDFSLGMESSPGAAGSFTYEAVELMPAGAQAQAAWRKSCASSPQAVLWSRAQQSEDRLPSAGMVEVKSSSSSSSTHSDNFLRLGSSPLEVPRSRSADHSLPGSSVSTDFGSWQMVTGCGSIREQATLSADASLPCSFPDEFPNTCLLLSASDRESRLEEVRSAFVASYSRTIGLKAVPPSPSGAIGGLLEQFVRGVGLRGSSTL", "length": 631 }, "evidence": [ { "id": "A0AAA9T6E4", "url": "https://omabrowser.org/oma/group/A0AAA9T6E4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GX87-1", "protein_name": "Myotubularin-related protein 14 isoform X1", "gene_name": "Mtmr14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGARAAASAEAGSTASSGNPPPQEPGLGELLEEFSRTQYRARDGGGASGSKVERIEKRCLELFGRDYCFSVIPNVNGDICGHYPRHIVYLEYESSEKEKDTFQSTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYFFSGGTDDTWADVDDVTEEDCALRSGDTHLFDKVRGHDIRLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLNIPGFLTQSLNIDWSQYQSWDLVQQTQNYLKLLLSIVNNDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFCLKTQRRKSLPTRDAGFTLEDIYTLRRRDRGSTTSLGSDFSLVLENSPGAVGSLTCETVELVPAGAPTQAAWRKSHSSSPQSMLWSRPQPSEDRLPSHHGLAEAKSSSSSSSNHSDNVFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLSALSDRETRLQEVRSAFLAAYSSTVGLRAVTPSPSGAIGGLLEQFARGVGLRGTSTSAL", "length": 648 }, "evidence": [ { "id": "A0AAA9T6E4", "url": "https://omabrowser.org/oma/group/A0AAA9T6E4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8NCE2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "MTMR14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGARAAAAAASAGSSASSGNQPPQELGLGELLEEFSRTQYRAKDGSGTGGSKVERIEKRCLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEYESSEKEKDTFESTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYFFSGGADDAWADVEDVTEEDCALRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFARGVGLRSISSNAL", "length": 650 }, "evidence": [ { "id": "A0AAA9T6E4", "url": "https://omabrowser.org/oma/group/A0AAA9T6E4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VEL2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "Mtmr14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGARAAAAASAGSTASSGSPPPQEPGLWELLEEFSRTQYRAKDSGGKSGSKVERIEKRCLELFGRDYCFSVIPNVNGDICGHYPRHIVFLEYESSEKEKDTFQSTVQVNKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYGRSGYNYLFSGGADDTWASTEDVTEEDFVLRSGDTHLFDKVRGYDIKLLQYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYANFTLLSIPYPGCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLNIPNFLTQSLNIDWSQYQSWDLVQQTQNYLKLLLFIMNRDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPAEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFCLKTQRRKSLPTRDAGFTVEDICMLRHKDRGSTTSLGSDFSLVLEHSPGAVGSFSYETVELAPAGAPTQAAWRKSHSSSPQSMLWSRPQPSEERLPSHHGLTEAKSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSSLSTDFGSWQLVSGCGSIQDRPVLHTDSSLPFSFQDELPNSCLLTALSDRETRLQEVRSAFLAAYSSTVGLRAATPSPSGAIGGLLEQFARGVGLRGTSTSTL", "length": 648 }, "evidence": [ { "id": "A0AAA9T6E4", "url": "https://omabrowser.org/oma/group/A0AAA9T6E4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-3-phosphate phosphatase activity", "id": "GO:0004438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004438", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "id": "GO:0052629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6E4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 518, "end_pos": 520 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6J5-1", "uniprot_ac": "A0AAA9T6J5", "uniprot_id": "A0AAA9T6J5_BOVIN", "mass": { "chemical_mass": 231171.0, "monoisotopic_mass": 231171.0 }, "refseq": {}, "gene_names": [ { "name": "ARHGAP32", "type": "recommended", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ] } ], "protein_names": [ { "name": "Rho GTPase-activating protein 32", "type": "recommended", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "Brain-specific Rho GTPase-activating protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "GAB-associated Cdc42/Rac GTPase-activating protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "GC-GAP", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "Rho-type GTPase-activating protein 32", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "Rho/Cdc42/Rac GTPase-activating protein RICS", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "p200RhoGAP", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] }, { "name": "p250GAP", "type": "synonym", "evidence": [ { "id": "A0AAA9T6J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. 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"MAAHQAPPSMGFSRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLSLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVTKNGCESKELVYLVHIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDALKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKINAVIQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVTSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERRRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAADGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNGSEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKPESECLESGASFLDSLGYSKDKQSTDKKDMETGGSQSQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEEKASKPSSFTEKVVYAFSPKIGRKISKSPSLNISEPISVTLPARVSEVISPVATTAAQNAPSAAWNKSSEESDVMNRSPTQVVKRKANEREAQEGCECEAQPPDQGAAADVGSPGKEEPASSSQSKAVPSGQTQTGADTHDPPQDSVPVSSVSLIPPPPPPKNAARLLALALAESAQQASTQPLKRPGTSPAACAHCGDAAVAAAEDRPPAPYSSVTLEKAYFQTDRPAEQPHLQNKGPGHGDQPVPDTAAAGDYTHSSTTDSTGQSPPADLPGDQPHRIYLSGDPEKARVTSVPLTDSKSDDLITFPEDQSVKTSVPTVSFVDHDQLHFYSGDEPPSYLGASMDKPHHPSELPDRSPAPSHLPRDKICPPSESPEENTSTAPLAYMTHAPAAAIASASEASWDVAEQPSAVEYVTATLQRAQRASRPLPLPPSQRPAEQPPVLGQVQTTASIGLTNPHKVQGAVPAPERPPDLGDPAPVLVGDGGAAAQCPASAPAPQPVLPEKVREGARAPALHLRAESVPAHASCGFPTPAPPARTMESRLAAALHSGSADGAGSAGYHSFVAAASAEEALPLPLPVPQAKHGPLKTAYPTFARPDLTTEPFGPESCLHFSMTPNCQFRPQSVPPHHGKAEPHPVYASRSEPPASTGPRYNTYVAPGRSVSGHHPKLCSRAEYVSSLSSSVRGGCYPEDMPPYPTIRRVQSLHVPPSSMIRSVPISRTEVPPDEEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYASSAGSYYSPDGALCDVDAYGTVQLRPLHRLPGRDLAFLAPRLQGKNVYTFAGGAASRPRPSVASYFPANDHNVVHMPPVADAKHAYASWDLEDLEKYRLQSIRRESRARQKAKGPVVSQYDNMSPAGAPDDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKALSPEGEDRFYRKHAEPELERAPHHQGGYGNGQPEKPCLPQKQSSIRNRKLHDAGCSLPEHRPHQEASHRQLCDPKNGPPFPQGAGPLDYGPKGLPDPAEPVSYLNSGGKYVPSGPESLRPSHKEVRLPKELERPRARQPPAAEKHPRDCYKEEEHLSQSALPPPKPERSHSLKLHHPQSADRDPGVLYHYHTHGKRPGRGTAGPQYDNLEGYHSPPQHQRGGFGAAAMGPYMPPGFPHPQSRTYATALGQGAFLPTELALQPPETQVHAE", "length": 2058, "header": "tr|A0A3Q1MMX7-1|A0AAA9T6J5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 32 OS=Bos taurus OX=9913 GN=ARHGAP32 PE=3 SV=2 CANONICAL=A0AAA9T6J5-1" }, "locus": { "chromosome": "29", "start_pos": 32478307, "end_pos": 32331150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077380.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077380.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072551.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072551.2" } ] } }, { "isoform_ac": "A0AAA9T1C4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#A0AAA9T1C4-1", "sequence": { "sequence": "MVFLYPVLILARGADVPEIPGDLSLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVTKNGCESKELVYLVHIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDALKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKINAVIQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVTSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERRRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAADGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNGSEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKPESECLESGASFLDSLGYSKDKQSTDKKDMETGGSQSQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEEKASKPSSFTEKVVYAFSPKIGRKISKSPSLNISEPISVTLPARVSEVISPVATTAAQNAPSAAWNKSSEESDVMNRSPTQVVKRKANEREAQEGCECEAQPPDQGAAADVGSPGKEEPASSSQSKAVPSGQTQTGADTHDPPQDSVPVSSVSLIPPPPPPKNAARLLALALAESAQQASTQPLKRPGTSPAACAHCGDAAVAAAEDRPPAPYSSVTLEKAYFQTDRPAEQPHLQNKGPGHGDQPVPDTAAAGDYTHSSTTDSTGQSPPADLPGDQPHRIYLSGDPEKARVTSVPLTDSKSDDLITFPEDQSVKTSVPTVSFVDHDQLHFYSGDEPPSYLGASMDKPHHPSELPDRSPAPSHLPRDKICPPSESPEENTSTAPLAYMTHAPAAAIASASEASWDVAEQPSAVEYVTATLQRAQRASRPLPLPPSQRPAEQPPVLGQVQTTASIGLTNPHKVQGAVPAPERPPDLGDPAPVLVGDGGAAAQCPASAPAPQPVLPEKVREGARAPALHLRAESVPAHASCGFPTPAPPARTMESRLAAALHSGSADGAGSAGYHSFVAAASAEEALPLPLPVPQAKHGPLKTAYPTFARPDLTTEPFGPESCLHFSMTPNCQFRPQSVPPHHGKAEPHPVYASRSEPPASTGPRYNTYVAPGRSVSGHHPKLCSRAEYVSSLSSSVRGGCYPEDMPPYPTIRRVQSLHVPPSSMIRSVPISRTEVPPDEEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYASSAGSYYSPDGALCDVDAYGTVQLRPLHRLPGRDLAFLAPRLQGKNVYTFAGGAASRPRPSVASYFPANDHNVVHMPPVADAKHAYASWDLEDLEKYRLQSIRRESRARQKAKGPVVSQYDNMSPAGAPDDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKALSPEGEDRFYRKHAEPELERAPHHQGGYGNGQPEKPCLPQKQSSIRNRKLHDAGCSLPEHRPHQEASHRQLCDPKNGPPFPQGAGPLDYGPKGLPDPAEPVSYLNSGGKYVPSGPESLRPSHKEVRLPKELERPRARQPPAAEKHPRDCYKEEEHLSQSALPPPKPERSHSLKLHHPQSADRDPGVLYHYHTHGKRPGRGTAGPQYDNLEGYHSPPQHQRGGFGAAAMGPYMPPGFPHPQSRTYATALGQGAFLPTELALQPPETQVHAE", "length": 2018, "header": "tr|A0AAA9T1C4-1|A0AAA9T6J5_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 32 OS=Bos taurus OX=9913 GN=ARHGAP32 PE=3 SV=1 CANONICAL=A0AAA9T6J5-1" }, "locus": { "chromosome": "29", "start_pos": 32438662, "end_pos": 32331150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123537.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123537.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090383.1" } ] } }, { "isoform_ac": "A0AAA9T6J5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#A0AAA9T6J5-1", "sequence": { "sequence": "MITLLLAPQPHTCVYISIAEQPGHCCAFAHALRFKLPKYTMETESESSTSGDDSVFWLDSEVITQVTGSEEGEGEEHFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLSLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVTKNGCESKELVYLVHIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDALKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKINAVIQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVTSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERRRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAADGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNGSEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKPESECLESGASFLDSLGYSKDKQSTDKKDMETGGSQSQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEEKASKPSSFTEKVVYAFSPKIGRKISKSPSLNISEPISVTLPARVSEVISPVATTAAQNAPSAAWNKSSEESDVMNRSPTQVVKRKANEREAQEGCECEAQPPDQGAAADVGSPGKEEPASSSQSKAVPSGQTQTGADTHDPPQDSVPVSSVSLIPPPPPPKNAARLLALALAESAQQASTQPLKRPGTSPAACAHCGDAAVAAAEDRPPAPYSSVTLEKAYFQTDRPAEQPHLQNKGPGHGDQPVPDTAAAGDYTHSSTTDSTGQSPPADLPGDQPHRIYLSGDPEKARVTSVPLTDSKSDDLITFPEDQSVKTSVPTVSFVDHDQLHFYSGDEPPSYLGASMDKPHHPSELPDRSPAPSHLPRDKICPPSESPEENTSTAPLAYMTHAPAAAIASASEASWDVAEQPSAVEYVTATLQRAQRASRPLPLPPSQRPAEQPPVLGQVQTTASIGLTNPHKVQGAVPAPERPPDLGDPAPVLVGDGGAAAQCPASAPAPQPVLPEKVREGARAPALHLRAESVPAHASCGFPTPAPPARTMESRLAAALHSGSADGAGSAGYHSFVAAASAEEALPLPLPVPQAKHGPLKTAYPTFARPDLTTEPFGPESCLHFSMTPNCQFRPQSVPPHHGKAEPHPVYASRSEPPASTGPRYNTYVAPGRSVSGHHPKLCSRAEYVSSLSSSVRGGCYPEDMPPYPTIRRVQSLHVPPSSMIRSVPISRTEVPPDEEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYASSAGSYYSPDGALCDVDAYGTVQLRPLHRLPGRDLAFLAPRLQGKNVYTFAGGAASRPRPSVASYFPANDHNVVHMPPVADAKHAYASWDLEDLEKYRLQSIRRESRARQKAKGPVVSQYDNMSPAGAPDDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKALSPEGEDRFYRKHAEPELERAPHHQGGYGNGQPEKPCLPQKQSSIRNRKLHDAGCSLPEHRPHQEASHRQLCDPKNGPPFPQGAGPLDYGPKGLPDPAEPVSYLNSGGKYVPSGPESLRPSHKEVRLPKELERPRARQPPAAEKHPRDCYKEEEHLSQSALPPPKPERSHSLKLHHPQSADRDPGVLYHYHTHGKRPGRGTAGPQYDNLEGYHSPPQHQRGGFGAAAMGPYMPPGFPHPQSRTYATALGQGAFLPTELALQPPETQVHAE", "length": 2123, "header": "tr|A0AAA9T6J5-1|A0AAA9T6J5_BOVIN Isoform 1 of Rho GTPase-activating protein 32 OS=Bos taurus OX=9913 GN=ARHGAP32 PE=3 SV=1 CANONICAL=A0AAA9T6J5-1" }, "locus": { "chromosome": "29", "start_pos": 32459386, "end_pos": 32331150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118502.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118502.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093511.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093511.1" } ] } }, { "isoform_ac": "F1N7Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5/entry#F1N7Q8-1", "sequence": { "sequence": "MGSSLVVFFTAFEGKLLRGAYSEAESWCLSASPAGLQRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLSLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVTKNGCESKELVYLVHIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDALKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKINAVIQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVTSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERRRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAADGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNGSEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKPESECLESGASFLDSLGYSKDKQSTDKKDMETGGSQSQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEEKASKPSSFTEKVVYAFSPKIGRKISKSPSLNISEPISVTLPARVSEVISPVATTAAQNAPSAAWNKSSEESDVMNRSPTQVVKRKANEREAQEGCECEAQPPDQGAAADVGSPGKEEPASSSQSKAVPSGQTQTGADTHDPPQDSVPVSSVSLIPPPPPPKNAARLLALALAESAQQASTQPLKRPGTSPAACAHCGDAAVAAAEDRPPAPYSSVTLEKAYFQTDRPAEQPHLQNKGPGHGDQPVPDTAAAGDYTHSSTTDSTGQSPPADLPGDQPHRIYLSGDPEKARVTSVPLTDSKSDDLITFPEDQSVKTSVPTVSFVDHDQLHFYSGDEPPSYLGASMDKPHHPSELPDRSPAPSHLPRDKICPPSESPEENTSTAPLAYMTHAPAAAIASASEASWDVAEQPSAVEYVTATLQRAQRASRPLPLPPSQRPAEQPPVLGQVQTTASIGLTNPHKVQGAVPAPERPPDLGDPAPVLVGDGGAAAQCPASAPAPQPVLPEKVREGARAPALHLRAESVPAHASCGFPTPAPPARTMESRLAAALHSGSADGAGSAGYHSFVAAASAEEALPLPLPVPQAKHGPLKTAYPTFARPDLTTEPFGPESCLHFSMTPNCQFRPQSVPPHHGKAEPHPVYASRSEPPASTGPRYNTYVAPGRSVSGHHPKLCSRAEYVSSLSSSVRGGCYPEDMPPYPTIRRVQSLHVPPSSMIRSVPISRTEVPPDEEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYASSAGSYYSPDGALCDVDAYGTVQLRPLHRLPGRDLAFLAPRLQGKNVYTFAGGAASRPRPSVASYFPANDHNVVHMPPVADAKHAYASWDLEDLEKYRLQSIRRESRARQKAKGPVVSQYDNMSPAGAPDDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKALSPEGEDRFYRKHAEPELERAPHHQGGYGNGQPEKPCLPQKQSSIRNRKLHDAGCSLPEHRPHQEASHRQLCDPKNGPPFPQGAGPLDYGPKGLPDPAEPVSYLNSGGKYVPSGPESLRPSHKEVRLPKELERPRARQPPAAEKHPRDCYKEEEHLSQSALPPPKPERSHSLKLHHPQSADRDPGVLYHYHTHGKRPGRGTAGPQYDNLEGYHSPPQHQRGGFGAAAMGPYMPPGFPHPQSRTYATALGQGAFLPTELALQPPETQVHAE", "length": 2082, "header": "tr|F1N7Q8-1|F1N7Q8_BOVIN Computationally mapped isoform of Rho GTPase-activating protein 32 OS=Bos taurus OX=9913 GN=ARHGAP32 PE=3 SV=4 CANONICAL=A0AAA9T6J5-1" }, "locus": { "chromosome": "29", "start_pos": 32452962, "end_pos": 32331150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021146.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021146.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021146.7", "url": "https://www.ensembl.org/id/ENSBTAP00000021146.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9013409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013409", "resource": "Reactome", "description": "RHOJ GTPase cycle" }, { "id": "R-BTA-9013423", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013423", "resource": "Reactome", "description": "RAC3 GTPase cycle" }, { "id": "R-BTA-9035034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9035034", "resource": "Reactome", "description": "RHOF GTPase cycle" }, { "id": "R-BTA-9768727", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9768727", "resource": "Reactome", "description": "Regulation of CDH1 posttranslational processing and trafficking to plasma membrane" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "regulation of dendritic spine morphogenesis", "id": "GO:0061001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061001", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "regulation of postsynapse assembly", "id": "GO:0150052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J5" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9B3-1", "uniprot_ac": "A0AAA9T9B3", "uniprot_id": "A0AAA9T9B3_BOVIN", "mass": { "chemical_mass": 199075.0, "monoisotopic_mass": 199075.0 }, "refseq": {}, "gene_names": [ { "name": "ARFGEF2", "type": "recommended", "evidence": [ { "id": "A0AAA9T9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ] } ], "protein_names": [ { "name": "ADP ribosylation factor guanine nucleotide exchange factor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARFGEF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3", "locus": { "chromosome": "13", "start_pos": 77181348, "end_pos": 77097658, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007120", "url": "https://www.ensembl.org/id/ENSBTAG00000007120" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007120", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007120", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00171", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539295", "url": "https://www.ncbi.nlm.nih.gov/gene/539295", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N0C8", "url": "https://www.orthodb.org/?gene=A0A3Q1N0C8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKI9", "url": "https://www.orthodb.org/?gene=E1BKI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10663:SF124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01369", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01369", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12783", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16213", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16213", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N0C8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0C8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKI9", "url": "https://www.uniprot.org/uniprotkb/E1BKI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKI9-1", "url": "https://www.uniprot.org/uniprotkb/E1BKI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGAAAPPKANFVEADKYFLPFELACQSRSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIHSKPQSPVIQAAAGSPKFNRLKQSQAQSKPTTPEKTDLTNGEHARSGSAVITENGHAPRERGPSLSEAAQKHGLTEPERVLSELECQERAAPPAADENSQTNGIADDRQSLSSADNLESDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFITAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERPVDQEMGDLARRSSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEMIEHGIELFNKKPKRGIQYLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGESMKFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYETLNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPDVWDETCNCMLDIFKTTIPHVLLTWRPVGMEDDPAEKHLDVDLDRQSLSSIDKNASERGQSQLSNPTDDGWKARPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKREDAEHMAAAQQDTLDTDIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLSVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPGSLSPIW", "length": 1756, "header": "tr|A0AAA9T9B3-1|A0AAA9T9B3_BOVIN Isoform 1 of ADP ribosylation factor guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=ARFGEF2 PE=4 SV=1 CANONICAL=A0AAA9T9B3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N0C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3/entry#A0A3Q1N0C8-1", "sequence": { "sequence": "MVVEDHLERDEIKAEIEKQRLGAAAPPKANFVEADKYFLPFELACQSRSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIHSKPQSPVIQAAAGSPKFNRLKQSQAQSKPTTPEKTDLTNGEHARSGSAVITENGHAPRERGPSLSGTEDGAQEVVKEILEDVVTSAVKEAAQKHGLTEPERVLSELECQERAAPPAADENSQTNGIADDRQSLSSADNLESDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFITAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERPVDQEMGDLARRSSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEMIEHGIELFNKKPKRGIQYLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGESMKFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYETLNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPDVWDETCNCMLDIFKTTIPHVLLTWRPVGMEDDPAEKHLDVDLDRQSLSSIDKNASERGQSQLSNPTDDGWKARPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKREDAEHMAAAQQDTLDTDIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLSVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPGSLSPIW", "length": 1748, "header": "tr|A0A3Q1N0C8-1|A0AAA9T9B3_BOVIN Computationally mapped isoform of ADP ribosylation factor guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=ARFGEF2 PE=4 SV=2 CANONICAL=A0AAA9T9B3-1" }, "locus": { "chromosome": "13", "start_pos": 77177827, "end_pos": 77106015, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062124.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062124.2" } ] } }, { "isoform_ac": "A0AAA9SU45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3/entry#A0AAA9SU45-1", "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGAAAPPKANFVEADKYFLPFELACQSRSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIHSKPQSPVIQAAAGSPKFNRLKQSQAQSKPTTPEKTDLTNGEHARSGSAVITENGHAPRERGPSLSGTEDGAQEVVKEILEDVVTSAVKEAAQKHGLTEPERVLSELECQERAAPPAADENSQTNGIADDRQSLSSADNLESDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFITAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERPVDQEMGDLARRSSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEMIEHGIELFNKKPKRGIQYLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGESMKFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQQSEVGDDESTAPGRWEKSRFGPRLCPGLSHQHPQPTEVLHSEPLRKSEWMTTTCNHALYAICDVFTQFYETLNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPDVWDETCNCMLDIFKTTIPHVLLTWRPVGMEDDPAEKHLDVDLDRQSLSSIDKNASERGQSQLSNPTDDGWKARPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKREDAEHMAAAQQDTLDTDIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLSVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPGSLSPIW", "length": 1821, "header": "tr|A0AAA9SU45-1|A0AAA9T9B3_BOVIN Computationally mapped isoform of ADP ribosylation factor guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=ARFGEF2 PE=4 SV=1 CANONICAL=A0AAA9T9B3-1" }, "locus": { "chromosome": "13", "start_pos": 77177827, "end_pos": 77097880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122425.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122425.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089948.1" } ] } }, { "isoform_ac": "A0AAA9T9B3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3/entry#A0AAA9T9B3-1", "sequence": { "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGAAAPPKANFVEADKYFLPFELACQSRSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIHSKPQSPVIQAAAGSPKFNRLKQSQAQSKPTTPEKTDLTNGEHARSGSAVITENGHAPRERGPSLSEAAQKHGLTEPERVLSELECQERAAPPAADENSQTNGIADDRQSLSSADNLESDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFITAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERPVDQEMGDLARRSSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEMIEHGIELFNKKPKRGIQYLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGESMKFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYETLNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPDVWDETCNCMLDIFKTTIPHVLLTWRPVGMEDDPAEKHLDVDLDRQSLSSIDKNASERGQSQLSNPTDDGWKARPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKREDAEHMAAAQQDTLDTDIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLSVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPGSLSPIW", 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"length": 1730, "header": "tr|E1BKI9-1|A0AAA9T9B3_BOVIN Computationally mapped isoform of ADP ribosylation factor guanine nucleotide exchange factor 2 OS=Bos taurus OX=9913 GN=ARFGEF2 PE=4 SV=3 CANONICAL=A0AAA9T9B3-1" }, "locus": { "chromosome": "13", "start_pos": 77177827, "end_pos": 77097880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009376.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009376.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009376.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009376.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "endosome organization", "id": "GO:0007032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "receptor recycling", "id": "GO:0001881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9B3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": 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], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1165, "end_pos": 1167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1489, "end_pos": 1491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 776, "end_pos": 778, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T9B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B3" }, { "id": "PS50190", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50190" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEC7", "eco_id": "ECO_0000259", "start_pos": 607, "end_pos": 796, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N9M7", "url": "https://www.orthodb.org/?gene=A0A3Q1N9M7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1ML33", "url": "https://www.orthodb.org/?gene=F1ML33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31493:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31493:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20721", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20721", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N9M7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N9M7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T991", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T991-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML33", "url": "https://www.uniprot.org/uniprotkb/F1ML33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML33-1", "url": "https://www.uniprot.org/uniprotkb/F1ML33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGVSGWTVGLRAASGPQRSRSRRPILAGARRAEPGSRAQQRGLRRRYRWAAPRKAPRGRAGRRGGGACARGGEAWCPRACRPVTSRRRLRRICHTTGGAVHPAHGRDPVLYRKWGTFLKTFGRVTFGWKGPSLIATVLRNAYPEVCRDARCGGGHHEVAVLHLRGEEDEGGRQALREGRPSHWGRGLRWWLGGRSTRTSRWGAVGGLLGAWMTSGQFKPVPQIIMELPPAEQQKLFNEATAIIRHLEWTDAVQLTMLVMGSEALQKQLLAMLANYVTRELRAEVQYDD", "length": 288, "header": "tr|A0AAA9T991-1|A0AAA9T991_BOVIN Isoform 1 of Chromosome 18 C19orf12 homolog OS=Bos taurus OX=9913 GN=C18H19orf12 PE=3 SV=1 CANONICAL=A0AAA9T991-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N9M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991/entry#A0A3Q1N9M7-1", "sequence": { "sequence": "ERKVPTKALGPAKAGKRSTARCCFDLLPVLPHGPSVPRNAYPEVCRDARCGGGHHEVAVLHLRGEEDEGGRQALREGRPSHWGRGLRWWLGGRSTRTSRWGAVGGLLGAWMTSGQFKPVPQIIMELPPAEQQKLFNEATAIIRHLEWTDAVQLTMLVMGSEALQKQLLAMLANYVTRELRAEVQYDD", "length": 187, "header": "tr|A0A3Q1N9M7-1|A0AAA9T991_BOVIN Computationally mapped isoform of Chromosome 18 C19orf12 homolog OS=Bos taurus OX=9913 GN=C18H19orf12 PE=3 SV=2 CANONICAL=A0AAA9T991-1" }, "locus": { "chromosome": "18", "start_pos": 40325810, "end_pos": 40319705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077269.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077269.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067866.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067866.2" } ] } }, { "isoform_ac": "A0AAA9S7N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991/entry#A0AAA9S7N5-1", "sequence": { "sequence": "TVGLRAASGPQRSRSRRPILAGARRAEPGSRAQQRGLRRRYRWAAPRKAPRGRAGRRGGGACARGGEAWCPRACRPVTSRRRLRRGAVGGLLGAWMTSGQFKPVPQIIMELPPAEQQKLFNEATAIIRHLEWTDAVQLTMLVMGSEALQKQLLAMLANYVTRELRAEVQYDD", "length": 172, "header": "tr|A0AAA9S7N5-1|A0AAA9T991_BOVIN Computationally mapped isoform of Chromosome 18 C19orf12 homolog OS=Bos taurus OX=9913 GN=C18H19orf12 PE=3 SV=1 CANONICAL=A0AAA9T991-1" }, "locus": { "chromosome": "18", "start_pos": 40330055, "end_pos": 40319705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108041.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108041.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082033.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082033.1" } ] } }, { "isoform_ac": "A0AAA9T991-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991/entry#A0AAA9T991-1", "sequence": { "sequence": "MGVSGWTVGLRAASGPQRSRSRRPILAGARRAEPGSRAQQRGLRRRYRWAAPRKAPRGRAGRRGGGACARGGEAWCPRACRPVTSRRRLRRICHTTGGAVHPAHGRDPVLYRKWGTFLKTFGRVTFGWKGPSLIATVLRNAYPEVCRDARCGGGHHEVAVLHLRGEEDEGGRQALREGRPSHWGRGLRWWLGGRSTRTSRWGAVGGLLGAWMTSGQFKPVPQIIMELPPAEQQKLFNEATAIIRHLEWTDAVQLTMLVMGSEALQKQLLAMLANYVTRELRAEVQYDD", "length": 288, "header": "tr|A0AAA9T991-1|A0AAA9T991_BOVIN Isoform 1 of Chromosome 18 C19orf12 homolog OS=Bos taurus OX=9913 GN=C18H19orf12 PE=3 SV=1 CANONICAL=A0AAA9T991-1" }, "locus": { "chromosome": "18", "start_pos": 40330073, "end_pos": 40319705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094566.1" } ] } }, { "isoform_ac": "F1ML33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T991/entry#F1ML33-1", "sequence": { "sequence": "ERKVPTKALGPAKAGKRSTARCCFDLLPVLPHGPSVPSLAPGETLHPFCLHLVGIQSVGGLSSSYRNAYPEVCRDARCGGGHHEVAVLHLRGEEDEGGRQALREGRPSHWGRGLRWWLGGRSTRTSRWGAVGGLLGAWMTSGQFKPVPQIIMELPPAEQQKLFNEATAIIRHLEWTDAVQLTMLVMGSEALQKQLLAMLANYVTRELRAEVQYDD", "length": 215, "header": "tr|F1ML33-1|A0AAA9T991_BOVIN Computationally mapped isoform of Chromosome 18 C19orf12 homolog OS=Bos taurus OX=9913 GN=C18H19orf12 PE=3 SV=2 CANONICAL=A0AAA9T991-1" }, "locus": { "chromosome": "18", "start_pos": 40325810, "end_pos": 40319705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027233.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027233.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027233.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027233.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8I0-1", "uniprot_ac": "A0AAA9T8I0", "uniprot_id": "A0AAA9T8I0_BOVIN", "mass": { "chemical_mass": 70564.0, "monoisotopic_mass": 70564.0 }, "refseq": { "ac": "XP_059733588", "name": "cationic amino acid transporter 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733588" }, "gene_names": [ { "name": "LOC528332", "type": "recommended", "evidence": [ { "id": "A0AAA9T8I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0" } ] }, { "name": "LOC528332", "type": "synonym", "evidence": [ { "id": "XP_059733588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733588" } ] } ], "protein_names": [ { "name": "Cationic amino acid transporter C-terminal domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T8I0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0/entry#names_and_taxonomy" } ] }, { "name": "cationic amino acid transporter 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059733588", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733588" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC528332", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0", "locus": {} } ], "crossref": [ { "id": "A0AAA9T8I0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8I0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528332", "url": "https://www.ncbi.nlm.nih.gov/gene/528332", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528332", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528332", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR43243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43243:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43243:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059733588", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733588", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRPRISSRSEPPQFSRMLCQDVHQFAQKLIRRRRLEPREESEKGRAHCLNTRDLTALGVSGTLGAGVYIVVGEVAVYEAGPAIIICFLLAGLSTLLSGLCYAELVARVPRSGSAYLYSYVTVGELCAFVIGWNLILSFVIGTASEARAWSIAFDSLIGNHISQAFQGTFSPYMPYFLARHPDFFALVLVLLLTGLLVLGLHESVMLNKVFAGLNLSILIIIIISGFIKGDLHNWKLTEQDYTLNTSESTDTSSLGPLGAGGFTPFGIEGILHGIATCVYAFDGFDVIATTGVEARNPQHSIPISIVITIFICFLVYVGGSAALTLMVPYYQIHPESFLPQAFLSVGWGPLRCVLAAITICALSSSLLGTMFPMLRVIYTMAGDGLLFRRLAQIHARTRTAMWTILASGSLAAVMALLFELTDLADLMSIGTLLAYSLVAFSVLVLRYQPEQNLSQNETAEEEIDISQLEARPLQSVPEAENSRILKTLWFPSSTIPTRKSGRIVYGCAFLLVLLLMVLSLILTLLTSRVFSGLSVYTTVAVLLLPITGITTIIWRQPQNPSPLHYKVLCWPILPLVSIFVNVYLMMQMNTRTWVQFGFWMGIGSVVYFGYGIRHSLGENNDQQPPDSNSQMLDGNIPGDESS", "length": 643, "header": "tr|A0AAA9T8I0-1|A0AAA9T8I0_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC528332 PE=3 SV=1 CANONICAL=A0AAA9T8I0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0/entry#A0A3Q1NJJ5-1", "sequence": { "sequence": "MLRPRISRSEPPQFSRMLCQDVHQFAQKLIRRRRLEPREESEKGRAHCLNTRDLTALGVSGTLGAGVYIVVGEVAVYEAGPAIIICFLLAGLSTLLSGLCYAELVARVPRSGSAYLYSYVTVGELCAFVIGWNLILSFVIGTASEARAWSIAFDSLIGNHISQAFQGTFSPYMPYFLARHPDFFALVLVLLLTGLLVLGLHESVMLNKVFAGLNLSILIIIIISGFIKGDLHNWKLTEQDYTLNTSESTDTSSLGPLGAGGFTPFGIEGILHGIATCVYAFDGFDVIATTGVEARNPQHSIPISIVITIFICFLVYVGGSAALTLMVPYYQIHPESFLPQAFLSVGWGPLRCVLAAITICALSSSLLGTMFPMLRVIYTMAGDGLLFRRLAQIHARTRTAMWTILASGSLAAVMALLFELTDLADLMSIGTLLAYSLVAFSVLVLRYQPEQNLSQNETAEEEIDISQLEARPLQSVPEAENSRILKTLWFPSSTIPTRKSGRIVYGCAFLLVLLLMVLSLILTLLTSRVFSGLSVYTTVAVLLLPITGITTIIWRQPQNPSPLHYKVLCWPILPLVSIFVNVYLMMQMNTRTWVQFGFWMGIGSVVYFGYGIRHSLGENNDQQPPDSNSQMLDGNIPGDESS", "length": 642, "header": "tr|A0A3Q1NJJ5-1|A0AAA9T8I0_BOVIN Computationally mapped isoform of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC528332 PE=3 SV=2 CANONICAL=A0AAA9T8I0-1" }, "locus": { "chromosome": "18", "start_pos": 61277782, "end_pos": 61269236, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070440.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070440.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072351.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072351.2" } ] } }, { "isoform_ac": "A0AAA9T8I0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0/entry#A0AAA9T8I0-1", "sequence": { "sequence": "MLRPRISSRSEPPQFSRMLCQDVHQFAQKLIRRRRLEPREESEKGRAHCLNTRDLTALGVSGTLGAGVYIVVGEVAVYEAGPAIIICFLLAGLSTLLSGLCYAELVARVPRSGSAYLYSYVTVGELCAFVIGWNLILSFVIGTASEARAWSIAFDSLIGNHISQAFQGTFSPYMPYFLARHPDFFALVLVLLLTGLLVLGLHESVMLNKVFAGLNLSILIIIIISGFIKGDLHNWKLTEQDYTLNTSESTDTSSLGPLGAGGFTPFGIEGILHGIATCVYAFDGFDVIATTGVEARNPQHSIPISIVITIFICFLVYVGGSAALTLMVPYYQIHPESFLPQAFLSVGWGPLRCVLAAITICALSSSLLGTMFPMLRVIYTMAGDGLLFRRLAQIHARTRTAMWTILASGSLAAVMALLFELTDLADLMSIGTLLAYSLVAFSVLVLRYQPEQNLSQNETAEEEIDISQLEARPLQSVPEAENSRILKTLWFPSSTIPTRKSGRIVYGCAFLLVLLLMVLSLILTLLTSRVFSGLSVYTTVAVLLLPITGITTIIWRQPQNPSPLHYKVLCWPILPLVSIFVNVYLMMQMNTRTWVQFGFWMGIGSVVYFGYGIRHSLGENNDQQPPDSNSQMLDGNIPGDESS", "length": 643, "header": "tr|A0AAA9T8I0-1|A0AAA9T8I0_BOVIN Isoform 1 of Cationic amino acid transporter C-terminal domain-containing protein OS=Bos taurus OX=9913 GN=LOC528332 PE=3 SV=1 CANONICAL=A0AAA9T8I0-1" }, "locus": { "chromosome": "18", "start_pos": 61277782, "end_pos": 61269236, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123538.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123538.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094268.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 122, "start_aa": "Thr", "end_pos": 122, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr122", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528332", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528332", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8I0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8I0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "amino acid transport", 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} ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 123, "end_pos": 125 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 277, "end_pos": 279 }, { "start_pos": 391, "end_pos": 393 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8L6-1", "uniprot_ac": "A0AAA9T8L6", "uniprot_id": "A0AAA9T8L6_BOVIN", "mass": { "chemical_mass": 111166.0, "monoisotopic_mass": 111166.0 }, "refseq": {}, "gene_names": [ { "name": "SNX14", "type": "recommended", "evidence": [ { "id": "A0AAA9T8L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ] } ], "protein_names": [ { "name": "Sorting nexin-14", "type": "recommended", "evidence": [ { "id": "A0AAA9T8L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6", "locus": { "chromosome": "9", "start_pos": 63971810, "end_pos": 63860299, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018408", "url": "https://www.ensembl.org/id/ENSBTAG00000018408" } ] } } ], "crossref": [ { "id": "A0AAA9T8L6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8L6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018408", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018408", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06877", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06877", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08722", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08722", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22775", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22775", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22775:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22775:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RTU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2A5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEW9-1", 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD26-1", "url": "https://www.uniprot.org/uniprotkb/E1BD26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGSLSLDDFRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVTEKRQHFIYVFNGVLTFF", "length": 953, "header": "tr|A0AAA9T8L6-1|A0AAA9T8L6_BOVIN Isoform 1 of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9RTU5-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 882, "header": "tr|A0AAA9RTU5-1|A0AAA9T8L6_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=2 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127117.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127117.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075418.2", "url": "https://www.ensembl.org/id/ENSBTAP00000075418.2" } ] } }, { "isoform_ac": "A0AAA9RUC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9RUC3-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 893, "header": "tr|A0AAA9RUC3-1|A0AAA9T8L6_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=2 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126628.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126628.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076766.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076766.2" } ] } }, { "isoform_ac": "A0AAA9T2A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9T2A5-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKETVIGIKTDSVHKSLPQNTL", "length": 945, "header": "tr|A0AAA9T2A5-1|A0AAA9T8L6_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63971730, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105111.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105111.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090761.1" } ] } }, { "isoform_ac": "A0AAA9T8L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9T8L6-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGSLSLDDFRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVTEKRQHFIYVFNGVLTFF", "length": 953, "header": "tr|A0AAA9T8L6-1|A0AAA9T8L6_BOVIN Isoform 1 of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63945937, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111940.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111940.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095079.1" } ] } }, { "isoform_ac": "A0AAA9TEW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9TEW9-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKEVTSVTSWI", "length": 934, "header": "tr|A0AAA9TEW9-1|A0AAA9TEW9_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129694.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129694.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097138.1" } ] } }, { "isoform_ac": "A0AAA9TMT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9TMT9-1", "sequence": { "sequence": "MIVLSFLKLLKILKIFLSCSLSPGYYQGLWMVDERNSYHSRFGREGNHWMLMYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 942, "header": "tr|A0AAA9TMT9-1|A0AAA9TMT9_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63879925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097495.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097495.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098551.1" } ] } }, { "isoform_ac": "A0AAA9TTA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9TTA3-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGSLSLDDFRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 919, "header": "tr|A0AAA9TTA3-1|A0AAA9TTA3_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105618.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105618.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100298.1" } ] } }, { "isoform_ac": "A0AAA9TZI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#A0AAA9TZI1-1", "sequence": { "sequence": "MEDVYVESLREWKLLIIYFIIWKVFQASMNKIMNFICGKINGYNLWTTVTDLWYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 943, "header": "tr|A0AAA9TZI1-1|A0AAA9TZI1_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=1 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63864139, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106764.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106764.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102983.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102983.1" } ] } }, { "isoform_ac": "E1BD26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6/entry#E1BD26-1", "sequence": { "sequence": "MAPWVRTIGEKLKQRLRLDVGREICRQYPLFCFLLLCLSAASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLLPNIFFMIKYKPKQLGLQELFPQGRSCAVCGKVKCKRHRPSLLLENYQPWLDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRIILRFFASVLIRRIHKVDIPSIITKKLLKAAMKHIEVIVKASQKVENTEFLQQAALEEYGPELHVALRSRRDELHYLRKLTELLFPYILPPKATDCRSLTLLLREILSGSVFLPSLDFLADPDTVNHLLIIFIDDNPPEKATEPPSPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQICLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCLDESVDKIRFDPFIVEEIQKIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGSLSLDDFRSTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGLAEGEDDFIEEGIVVMEDDSPVEAVNTPNTPRNLAAWKISIPYVDFFEDTSSERREKKERIPVFCIDVERNDRRAGTFPDAQLPSKRIIGPKNYEFLKSKREEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPDVNLGKIIKSVPGKLMKEKGQHLEPFIMNFINSCESPKPKPSKPELTILSPTSENNKKLFNDLYKNNANRAENTERRQNQNYFMEMMTVEGVYDYLMYVGQVVFQVPDWLHHLLMGTRILFKNTLEMYTDYYLHCKLEQLFQEHRLVSLITLLRDAVFCENTEPRSLQDKQKRAKQTFEGMMNYIPDLIVKCIGEEAKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQKEVTSVTSWI", "length": 918, "header": "tr|E1BD26-1|A0AAA9T8L6_BOVIN Computationally mapped isoform of Sorting nexin-14 OS=Bos taurus OX=9913 GN=SNX14 PE=3 SV=4 CANONICAL=A0AAA9T8L6-1" }, "locus": { "chromosome": "9", "start_pos": 63946836, "end_pos": 63862949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031642.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031642.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031592.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031592.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "postsynaptic modulation of chemical synaptic transmission", "id": "GO:0099170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 570, "end_pos": 690, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T8L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" }, { "id": "PS51207", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51207" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PXA", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 304, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T8L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L6" }, { "id": "PS50132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RGS", "eco_id": "ECO_0000259", "start_pos": 336, "end_pos": 468, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5L4-1", "uniprot_ac": "A0AAA9T5L4", "uniprot_id": "A0AAA9T5L4_BOVIN", "mass": { "chemical_mass": 109693.0, "monoisotopic_mass": 109693.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC66", "type": "recommended", "evidence": [ { "id": "A0AAA9T5L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 66", "type": "synonym", "evidence": [ { "id": "A0AAA9T5L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC66", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4", "locus": { "chromosome": "22", "start_pos": 44403086, "end_pos": 44521424, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019746", "url": "https://www.ensembl.org/id/ENSBTAG00000019746" } ] } } ], "crossref": [ { "id": "A0AAA9T5L4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5L4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534513", "url": "https://www.ncbi.nlm.nih.gov/gene/534513", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR039183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLR5", "url": "https://www.orthodb.org/?gene=F1MLR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22736", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22736", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22736:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22736:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RV96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S588", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S588", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S588-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S588-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STF3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLR5", "url": "https://www.uniprot.org/uniprotkb/F1MLR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLR5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLGDGLKLETELLNGKTKLILSPYDHKSKVSGKMGNKTKIAKYPLRTKTGYILKSQNTCVRSEKFLQKKRIGSETSLLKGEENSMTFSPTKDLCKQSVDKDSLHTEKEISFAPPNIQKTRNTMNPFVVAKQKPCRKHITAENRKSGLVCLTEDQLQRILMTVNQGSKSITLTENEKEEETSQYSLNNIPDQPKDENIMGLLQNTETVSSIQDESKSVLNKNQATSNQCEQKISTENVWKPADIFSTLGERERDRSLLEAKKAQWRKELDEQVALKKKEKEASEKWNNPWKKSESDKIEWEKLQIVDQSKEAVLLEQPFSAVKQEQQRKWIEELNKQIEDDRQKKAEEKIISSMAEERDRWAMHFDSLKNYPGSQSRLSSQSVQKQPEYFCVSPDTQELADISSLYTPTVGSQIEPSEEEHTVKPFRDTAVANIQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRKKKQLEEEQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEMMTLQTNKLFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGIDTIQVEYNASTNNTGNSRHGLDKVSGKMNTYINSATSPRKDTGVQTDDLNIGVFTNTESRCGSVSEREIINCSSPEIAAEFNEQFNTKNNKQELVSQIKGANLEKENSWYNDQCNQITRREKQTKHMKKCPKRPDWNINKPLRRYIPASEKYPKQLQKLREEKKVRRQMELLHLIERSNPGQISQNRGTSPEVLLSSHQETDPSFRRQLVRKEEEPLRTNCFSRERSQSPPFPAVKSRTQQTQTLKNSNYERENLISGHSQTELSPGISDPFHFIPYVRTKEVYYLDPDAPLSRPVTQNPQYQNAHASDREQELFASDHLRDPLLNPNLVKNRDRQQAILKGLSDLRQGLLQKQRELETNLMPLAANQEENFSSSF", "length": 945, "header": "tr|A0AAA9T5L4-1|A0AAA9T5L4_BOVIN Isoform 1 of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=1 CANONICAL=A0AAA9T5L4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RV96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#A0AAA9RV96-1", "sequence": { "sequence": "MNLGDGLKLETELLNGKTKLILSPYDHKSKVSGKMGNKTKIAKYPLRTKTGYILKSQNTCVRSEKFLQKKRIGSETSLLKGEENSMTFSPTKDLCKQSVDKDSLHTEKEISFAPPNIQKTRNTMNPFVVAKQKPCRKHITAENRKSGLVCLTEDQLQRILMTVNQGSKSITLTENEKEEETSQYSLNNIPDQPKDENIMGLLQNTETVSSIQDESKSVLNKNQATSNQCEQKISTENVWKPADIFSTLGERERDRSLLEAKKAQWRKELDEQVALKKKEKEASEKWNNPWKKSESDKIEWEKLQIVDQSKTSACSSSILSQSPSQVMVIHADGPSLPRASQTSQEAVLLEQPFSAVKQEQQRKWIEELNKQIEDDRQKKAEEKIISSMAEERDRWAMHFDSLKNYPGSQSRLSSQSVQKQPEYFCVSPDTQELADISSLYTPTVGSQIEPSEEEHTVKPFRDTAVANIQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRKKKQLEEEQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEMMTLQTNKLFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGIDTIQVEYNASTNNTGNSRHGLDKVSGKMNTYINSATSPRKDTGVQTDDLNIGVFTNTESRCGSVSEREIINCSSPEIAAEFNEQFNTKNNKQELVSQIKGANLEKENSWYNDQCNQITRREKQTKHMKKCPKRPDWNINKPLRRYIPASEKYPKQLQKLREEKKVRRQMELLHLIERSNPGQISQNRGTSPEVLLSSHQETDPSFRRQLVRKEEEPLRTNCFSRERSQSPPFPAVKSRTQQTQTLKNSNYERENLISGHSQTELSPGISDPFHFIPYVRTKEVYYLDPDAPLSRPVTQNPQYQNAHDREQELFASDHLRDPLLNPNLVKNRDRQQAILKGLSDLRQV", "length": 950, "header": "tr|A0AAA9RV96-1|A0AAA9T5L4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=1 CANONICAL=A0AAA9T5L4-1" }, "locus": { "chromosome": "22", "start_pos": 44442693, "end_pos": 44404693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107713.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107713.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076195.1" } ] } }, { "isoform_ac": "A0AAA9S588-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#A0AAA9S588-1", "sequence": { "sequence": "MSRDGLKLETELLNGKTKLILSPYDHKSKVSGKMGNKTKIAKYPLRTKTGYILKSQNTCVRSEKFLQKKRIGSETSLLKGEENSMTFSPTKDLCKQSVDKDSLHTEKEISFAPPNIQKTRNTMNPFVVAKQKPCRKHITAENRKSGLVCLTEDQLQRILMTVNQGSKSITLTENEKEEETSQYSLNNIPDQPKDENIMGLLQNTETVSSIQDESKSVLNKNQATSNQCEQKISTENVWKPADIFSTLGERERDRSLLEAKKAQWRKELDEQVALKKKEKEASEKWNNPWKKSESDKIEWEKLQIVDQSKTSACSSSILSQSPSQVMVIHADGPSLPRASQTSQEAVLLEQPFSAVKQEQQRKWIEELNKQIEDDRQKKAEEKIISSMAEERDRWAMHFDSLKNYPGSQSRLSSQSVQKQPEYFCVSPDTQELADISSLYTPTVGSQIEPSEEEHTVKPFRDTAVANIQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRKKKQLEEEQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEMMTLQTNKLFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGIDTIQVEYNASTNNTGNSRHGLDKVSGKMNTYINSATSPRKDTGVQTDDLNIGVFTNTESRCGSVSEREIINCSSPEIAAEFNEQFNTKNNKQELVSQIKGANLEKENSWYNDQCNQITRREKQTKHMKKCPKRPDWNINKPLRRYIPASEKYPKQLQKLREEKKVRRQMELLHLIERSNPGQISQNRGTSPEVLLSSHQETDPSFRRQLVRKEEEPLRTNCFSRERSQSPPFPAVKSRTQQTQTLKNSNYERENLISGHSQTELSPGISDPFHFIPYVRTKEVYYLDPDAPLSRPVTQNPQYQNAHDREQELFASDHLRDPLLNPNLVKNRDRQQAILKGLSDLRQGLLQKQRELETNLMPLAANQEENFSSSF", "length": 976, "header": "tr|A0AAA9S588-1|A0AAA9T5L4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=1 CANONICAL=A0AAA9T5L4-1" }, "locus": { "chromosome": "22", "start_pos": 44507298, "end_pos": 44403379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126803.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126803.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078401.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078401.1" } ] } }, { "isoform_ac": "A0AAA9STF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#A0AAA9STF3-1", "sequence": { "sequence": "MEKPSLYCLHMMGNKTKIAKYPLRTKTGYILKSQNTCVRSEKFLQKKRIGSETSLLKGEENSMTFSPTKDLCKQSVDKDSLHTEKEISFAPPNIQKTRNTMNPFVVAKQKPCRKHITAENRKSGLVCLTEDQLQRILMTVNQGSKSITLTENEKEEETSQYSLNNIPDQPKDENIMGLLQNTETVSSIQDESKSVLNKNQATSNQCEQKISTENVWKPADIFSTLGERERDRSLLEAKKAQWRKELDEQVALKKKEKEASEKWNNPWKKSESDKIEWEKLQIVDQSKTSACSSSILSQSPSQVMVIHADGPSLPRASQTSQEAVLLEQPFSAVKQEQQRKWIEELNKQIEDDRQKKAEEKIISSMAEERDRWAMHFDSLKNYPGSQSRLSSQSVQKQPEYFCVSPDTQELADISSLYTPTVGSQIEPSEEEHTVKPFRDTAVANIQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRKKKQLEEEQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEMMTLQTNKLFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGIDTIQVEYNASTNNTGNSRHGLDKVSGKMNTYINSATSPRKDTGVQTDDLNIGVFTNTESRCGSVSEREIINCSSPEIAAEFNEQFNTKNNKQELVSQIKGANLEKENSWYNDQCNQITRREKQTKHMKKCPKRPDWNINKPLRRYIPASEKYPKQLQKLREEKKVRRQMELLHLIERSNPGQISQNRGTSPEVLLSSHQETDPSFRRQLVRKEEEPLRTNCFSRERSQSPPFPAVKSRTQQTQTLKNSNYERENLISGHSQTELSPGISDPFHFIPYVRTKEVYYLDPDAPLSRPVTQNPQYQNAHDREQELFASDHLRDPLLNPNLVKNRDRQQAILKGLSDLRQGLLQKQRELETNLMPLAANQEENFSSSF", "length": 954, "header": "tr|A0AAA9STF3-1|A0AAA9T5L4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=1 CANONICAL=A0AAA9T5L4-1" }, "locus": { "chromosome": "22", "start_pos": 44440739, "end_pos": 44403379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134080.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134080.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087421.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087421.1" } ] } }, { "isoform_ac": "A0AAA9T5L4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#A0AAA9T5L4-1", "sequence": { "sequence": "MNLGDGLKLETELLNGKTKLILSPYDHKSKVSGKMGNKTKIAKYPLRTKTGYILKSQNTCVRSEKFLQKKRIGSETSLLKGEENSMTFSPTKDLCKQSVDKDSLHTEKEISFAPPNIQKTRNTMNPFVVAKQKPCRKHITAENRKSGLVCLTEDQLQRILMTVNQGSKSITLTENEKEEETSQYSLNNIPDQPKDENIMGLLQNTETVSSIQDESKSVLNKNQATSNQCEQKISTENVWKPADIFSTLGERERDRSLLEAKKAQWRKELDEQVALKKKEKEASEKWNNPWKKSESDKIEWEKLQIVDQSKEAVLLEQPFSAVKQEQQRKWIEELNKQIEDDRQKKAEEKIISSMAEERDRWAMHFDSLKNYPGSQSRLSSQSVQKQPEYFCVSPDTQELADISSLYTPTVGSQIEPSEEEHTVKPFRDTAVANIQKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRKKKQLEEEQRKKEEQEEERRLAREREEMQKQYEEDILKQKQKEEMMTLQTNKLFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGIDTIQVEYNASTNNTGNSRHGLDKVSGKMNTYINSATSPRKDTGVQTDDLNIGVFTNTESRCGSVSEREIINCSSPEIAAEFNEQFNTKNNKQELVSQIKGANLEKENSWYNDQCNQITRREKQTKHMKKCPKRPDWNINKPLRRYIPASEKYPKQLQKLREEKKVRRQMELLHLIERSNPGQISQNRGTSPEVLLSSHQETDPSFRRQLVRKEEEPLRTNCFSRERSQSPPFPAVKSRTQQTQTLKNSNYERENLISGHSQTELSPGISDPFHFIPYVRTKEVYYLDPDAPLSRPVTQNPQYQNAHASDREQELFASDHLRDPLLNPNLVKNRDRQQAILKGLSDLRQGLLQKQRELETNLMPLAANQEENFSSSF", "length": 945, "header": "tr|A0AAA9T5L4-1|A0AAA9T5L4_BOVIN Isoform 1 of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=1 CANONICAL=A0AAA9T5L4-1" }, "locus": { "chromosome": "22", "start_pos": 44442693, "end_pos": 44403379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106898.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106898.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093114.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093114.1" } ] } }, { "isoform_ac": "F1MLR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4/entry#F1MLR5-1", "sequence": { "sequence": 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"tr|F1MLR5-1|A0AAA9T5L4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 66 OS=Bos taurus OX=9913 GN=CCDC66 PE=4 SV=4 CANONICAL=A0AAA9T5L4-1" }, "locus": { "chromosome": "22", "start_pos": 44442693, "end_pos": 44404354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061607.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061607.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053266.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053266.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5L4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L4" } ], "pmid": "" }, { "name": 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"https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299286", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299286", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MF26", "url": "https://www.orthodb.org/?gene=F1MF26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841690", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841690", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5T6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF26", "url": "https://www.uniprot.org/uniprotkb/F1MF26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF26-1", "url": "https://www.uniprot.org/uniprotkb/F1MF26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1133, "header": "tr|A0AAA9T5T6-1|A0AAA9T5T6_BOVIN Isoform 1 of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=1 CANONICAL=A0AAA9T5T6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6/entry#A0AAA9RWQ8-1", "sequence": { "sequence": "MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1105, "header": "tr|A0AAA9RWQ8-1|A0AAA9T5T6_BOVIN Computationally mapped isoform of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=1 CANONICAL=A0AAA9T5T6-1" }, "locus": { "chromosome": "26", "start_pos": 24410106, "end_pos": 24168685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119720.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119720.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077878.1" } ] } }, { "isoform_ac": "A0AAA9RZD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6/entry#A0AAA9RZD8-1", "sequence": { "sequence": "MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1118, "header": "tr|A0AAA9RZD8-1|A0AAA9T5T6_BOVIN Computationally mapped isoform of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=1 CANONICAL=A0AAA9T5T6-1" }, "locus": { "chromosome": "26", "start_pos": 24410106, "end_pos": 24168685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075157.1" } ] } }, { "isoform_ac": "A0AAA9STZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6/entry#A0AAA9STZ6-1", "sequence": { "sequence": "MGLKTKHSVWVGPPFVFIREVTGEPHPRWGMDPAIRPRQGDLVKMAASGAPHLPQRSWTLSLGRLLPPGRGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1112, "header": "tr|A0AAA9STZ6-1|A0AAA9T5T6_BOVIN Computationally mapped isoform of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=1 CANONICAL=A0AAA9T5T6-1" }, "locus": { "chromosome": "26", "start_pos": 24285079, "end_pos": 24168685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126391.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126391.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088813.1" } ] } }, { "isoform_ac": "A0AAA9T5T6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6/entry#A0AAA9T5T6-1", "sequence": { "sequence": "MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1133, "header": "tr|A0AAA9T5T6-1|A0AAA9T5T6_BOVIN Isoform 1 of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=1 CANONICAL=A0AAA9T5T6-1" }, "locus": { "chromosome": "26", "start_pos": 24410106, "end_pos": 24168685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120825.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120825.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091119.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091119.1" } ] } }, { "isoform_ac": "F1MF26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6/entry#F1MF26-1", "sequence": { "sequence": "MVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSGADSNAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYASQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDELPARKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGLEPPITKKEISLPILCNASNGSALGIPERTVSKLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEADEGPAGPGESQDSPLRLKYEEPEYDIPAFGFDSEPELTEEPTEDGGSGDRRPTQPHRPSPASSLQRARFKVGGSTEDVALEEETIYENEGFRPCVEDGLSARRSSRDSDSPGGSPLSLARKNSPKSDSPKSSSLLKLKAEKNAQAELGKNHSSASFSSSITINTTCSSSSSSSSSSLSKNSGDLKPRSASDAGIRGTPKVGAKKDADPKVGLTSCARAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTAFEGPSEGSRRGSADLITLPAASPPCPTKKGREGQATSYTTCSAYQKVQDSEISFPAGVEVQVLEKLESGWWYVRFGELEGWAPAHYLVLGENEPSDPPGKETDTVAPKSKQNEGKSDSLEKIEKRVQALNTVNQSKRATPPIPSKPPGGFVKTSGAGAVKMRNGVRQVAVRPQSVFVSPPPKDSNLSCALRRNESLTATDNLRGVRRNSSFSAARSAAAEAKGRLAERAASQGSEPPLLPTQRNGIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDDETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN", "length": 1095, "header": "tr|F1MF26-1|A0AAA9T5T6_BOVIN Computationally mapped isoform of SH3 and PX domain-containing protein 2A OS=Bos taurus OX=9913 GN=SH3PXD2A PE=3 SV=4 CANONICAL=A0AAA9T5T6-1" }, "locus": { "chromosome": "26", "start_pos": 24362683, "end_pos": 24168685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061357.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061357.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053833.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053833.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100299286", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299286", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "podosome", "id": "GO:0002102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "osteoclast fusion", "id": "GO:0072675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072675", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "superoxide metabolic process", "id": "GO:0006801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006801", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate binding", "id": "GO:0070273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1000, "end_pos": 1002, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1015, "end_pos": 1017, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 233, "end_pos": 235, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 684, "end_pos": 686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" }, { "start_pos": 992, "end_pos": 994, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 128, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5T6" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 225, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1000, "end_pos": 1002 }, { "start_pos": 1015, "end_pos": 1017 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 233, "end_pos": 235 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 509, "end_pos": 511 }, { "start_pos": 684, "end_pos": 686 }, { "start_pos": 697, "end_pos": 699 }, { "start_pos": 940, "end_pos": 942 }, { "start_pos": 992, "end_pos": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5F1-1", "uniprot_ac": "A0AAA9T5F1", "uniprot_id": "A0AAA9T5F1_BOVIN", "mass": { "chemical_mass": 57046.0, "monoisotopic_mass": 57046.0 }, "refseq": { "ac": "XP_024832652", "name": "protein-cysteine N-palmitoyltransferase HHAT isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832652" }, "gene_names": [ { "name": "HHAT", "type": "recommended", "evidence": [ { "id": "A0AAA9T5F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1" } ] }, { "name": "HHAT", "type": "synonym", "evidence": [ { "id": "XP_024832652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832652" } ] } ], "protein_names": [ { "name": "Hedgehog acyltransferase", "type": "synonym", "evidence": [ { "id": "A0AAA9T5F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#names_and_taxonomy" } ] }, { "name": "protein-cysteine N-palmitoyltransferase HHAT isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024832652", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832652" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HHAT", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1", "locus": { "chromosome": "16", "start_pos": 72650367, "end_pos": 73012898, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000048628", "url": "https://www.ensembl.org/id/ENSBTAG00000048628" } ] } } ], "crossref": [ { "id": "A0AAA9T5F1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5F1", "database": "AlphaFoldDB", "categories": [] }, { "id": "100336796", "url": "https://www.ncbi.nlm.nih.gov/gene/100336796", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336796", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336796", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AWAQTYT", "url": "https://omabrowser.org/oma/group/AWAQTYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13285", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13285", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13285:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13285:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03062", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03062", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024832652", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832652", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY70", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T381", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T381", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T381-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T381-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKDPTDFEWSFWMEWGKERLVWLFLGHMSVSQVANLISRKHKPWILAVYGMWACRCVLGTQGTAMVLIHATISFCVAQFRSQFLSWLCSLSLLSTLRLQDVEEVKRGWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQPPPAERPFYSLPWMLAYVFYYPVFHNGPVLSFPEFIAQMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQGWPWVTLSVLGFLYCYSHVGIAWAHTYSGH", "length": 493, "header": "tr|A0AAA9T5F1-1|A0AAA9T5F1_BOVIN Isoform 1 of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=1 CANONICAL=A0AAA9T5F1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY70-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#A0AAA9RY70-1", "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKHKPWILAVYGMWACRCVLGTQGTAMVLIHATISFCVAQFRSQFLSWLCSLSLLSTLRLQDVEEVKRGWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQPPPAERPFYSLPWMLAYVFYYPVFHNGPVLSFPEFIAQMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQGWPWVTLSVLGFLYCYSHVGIAWAHTYSGH", "length": 455, "header": "tr|A0AAA9RY70-1|A0AAA9T5F1_BOVIN Computationally mapped isoform of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=2 CANONICAL=A0AAA9T5F1-1" }, "locus": { "chromosome": "16", "start_pos": 72995190, "end_pos": 72651371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078500.2", "url": "https://www.ensembl.org/id/ENSBTAP00000078500.2" } ] } }, { "isoform_ac": "A0AAA9SHL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#A0AAA9SHL2-1", "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKDPTDFEWSFWMEWGKERLVWLFLGHMSVSQVANLISRKRGWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQPPPAERPFYSLPWMLAYVFYYPVFHNGPVLSFPEFIAQMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQGWPWVTLSVLGFLYCYSHVGIAWAHTYSGH", "length": 428, "header": "tr|A0AAA9SHL2-1|A0AAA9T5F1_BOVIN Computationally mapped isoform of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=1 CANONICAL=A0AAA9T5F1-1" }, "locus": { "chromosome": "16", "start_pos": 72995190, "end_pos": 72651371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098907.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098907.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083218.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083218.1" } ] } }, { "isoform_ac": "A0AAA9SRX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#A0AAA9SRX6-1", "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKDPTDFEWSFWMEWGKERLVWLFLGHMSVSQVANLISRKMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQGWPWVTLSVLGFLYCYSHVGIAWAHTYSGH", "length": 356, "header": "tr|A0AAA9SRX6-1|A0AAA9T5F1_BOVIN Computationally mapped isoform of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=1 CANONICAL=A0AAA9T5F1-1" }, "locus": { "chromosome": "16", "start_pos": 72995190, "end_pos": 72651371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107625.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107625.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089136.1" } ] } }, { "isoform_ac": "A0AAA9T381-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#A0AAA9T381-1", "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKDPTDFEWSFWMEWGKERLVWLFLGHMSVSQVANLISRKHKPWILAVYGMWACRCVLGTQGTAMVLIHATISFCVAQFRSQFLSWLCSLSLLSTLRLQDVEEVKRGWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQPPPAERPFYSLPWMLAYVFYYPVFHNGPVLSFPEFIAQMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQDK", "length": 465, "header": "tr|A0AAA9T381-1|A0AAA9T5F1_BOVIN Computationally mapped isoform of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=1 CANONICAL=A0AAA9T5F1-1" }, "locus": { "chromosome": "16", "start_pos": 72995190, "end_pos": 72692976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122462.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122462.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090147.1" } ] } }, { "isoform_ac": "A0AAA9T5F1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1/entry#A0AAA9T5F1-1", "sequence": { "sequence": "MLPRWELSLYLLASIGFHFYSFYEVYKVSREHEEELDREFDLETGTLFRGLKKDPTDFEWSFWMEWGKERLVWLFLGHMSVSQVANLISRKHKPWILAVYGMWACRCVLGTQGTAMVLIHATISFCVAQFRSQFLSWLCSLSLLSTLRLQDVEEVKRGWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQPPPAERPFYSLPWMLAYVFYYPVFHNGPVLSFPEFIAQMQQQEQSSPKTSLSILALGLGRLLFYWWLAELMVHLMYMHAIYSSASLLRAVSSWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLRPPPLPRCVSTMFSFTGMWRHFDVGLHDFLVRYVYIPAGGSQHGLLGALFSTAMTFAFVSFWHGGNDYLWCWATLNWLGVTVENGVQKLVQRPHVQHSLAQFLSPGARRRLHAALASCSTSMLILSNLVFLGGSQVGEIYWDRIFIQGWPWVTLSVLGFLYCYSHVGIAWAHTYSGH", "length": 493, "header": "tr|A0AAA9T5F1-1|A0AAA9T5F1_BOVIN Isoform 1 of Hedgehog acyltransferase OS=Bos taurus OX=9913 GN=HHAT PE=3 SV=1 CANONICAL=A0AAA9T5F1-1" }, "locus": { "chromosome": "16", "start_pos": 72995190, "end_pos": 72651371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130064.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130064.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091784.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336796", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336796", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GIY5-1", "protein_name": "Hedgehog acyltransferase", "gene_name": "Hhat", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYRAPANPLSRQPGATSQAKAFTPAASDRRSPQPSRVLPGPGLRAAGCRDAFFPAHSALHAAIQKLSTLHWEAESPAMLSRWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWLEWGKQRLVWLLLGHMAVSQLATLLTKKHRPWIIMIYGMWACWCVLGAPGVVMVLLHTTIAFCVAQFRSMLLSWLCSLLLLSTLRLQSVEEVKRRWYKTESEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQRACFSFPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELSSLQHSLCILAKGLGRLLCWWWLAELMVHLMYMHALYSSIPLLESVSCWTLGGLALAQVLFFYVKYLVLFGAPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTAMTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLQTPCVRETLARHLSPQARRRLHALLASCSTSMLILFNLVFLEGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVGIAWAQTYTVL", "length": 570 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Z8B9-1", "protein_name": "Hedgehog acyltransferase", "gene_name": "HHAT", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKNSRAAPRPVVLPAWEMCAYLFLTIGSHFYSFYEAYQVSQKYEDEIDRSFGLEQGTLFWGLKKDALDFEWSYWIEWGREYILWLLAGHLLVSQMCRLFMDKYKPWCLMVYGMAACWFLLGIKGFAVILVHTAISFAVAQFQIPLLTWLCSLILLSTLRIPAVEEAKREWYDTENEYYLLLFTVSVRCLFNTSFSLEYCWNGRAQKSSHSFLWMLAYVFYYPMFHNGPLMNFDEFSKQMRKQEAFSLKTNLVILIVGIIRIFFWWCLAELMIHFMYIHAICSTSSSLEAMSYWALGGVALAQVLFFYVKYLVLYGIAALLLRMDGLRPPALPRCVSLMHSFTKMWRSFDVGLHRFLVRYIYVPMGGSQSSLPGMLFSTALTFAFVSYWHGGQSYLWYWGVLNWLGVIVENGVKRILSVSPIQDLIERFFSPRVHRRLHAVLASVCTSMLILSNLIFLGGNHVGKVYWNRIFMEGQIICENSSNCGTFIAELRLALNLDGQKLKSGYLSGVLLWEKIDCLFKSCSKELLKYLHYLDRKISSLLVLNIDRKVCLFHHLWVNVHHMVKKMACK", "length": 570 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S2U1-1", "protein_name": "Hedgehog acyltransferase", "gene_name": "HHAT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPRWELSFYLFASLGFHFYSFYEVFKVSREHEEELDQEFDLETDSLFGGLKKDPTDFEWSFWMEWGKQRLAWLLLGHVGVSQVANLLARKHRPWILAAYGMWACHCALGTRGTAMVLLHTTISFCVAQFRSLALSWLCSLFLLSTLRLQDVEEVKRGWYETENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAERAFYSFPWMVAYVFYYPVFHNGPILSFPEFLTQMQPREQGSLKASFSILVRGLGRLLFYWWLVELMVHLMYMHAICSSAPLLSAVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLSPPPLPRCVSTMFSFTGMWRYFDVGLHDFLVRYVYIPVGGSQHGLLGTLFSTAVTFAFVSYWHGGNDYLWCWAALNWLGVTVESGVRRLVQKPSIQDSLAQVLSPQARRRFHAALASCSTSMLILSNLVFLGGNQVGKSTGIGSSFKAGHG", "length": 467 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F8W2J4-1", "protein_name": "Protein-cysteine N-palmitoyltransferase HHAT", "gene_name": "hhat", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTPKWELVSLPRWEMVAYWILSFSSHFYSFYQLHSFSKEHEVSLDKEVQLERGFLLWGFKKDPTDFEWSFWNEWAWRSLLWSLIGHAVVSRLAYYYLPQYRLAVFAMYGLISAGWILGVRGVIVLMLHLSISLVVAQLRSPVLSWFCSLLLLSTLNVSALQDLQRGWYTSEDQYYLLLFSTAVCSLHCISFCLEMCWHPLQAGRPKHCSSLQNCALKTLIYQFLKLTAFCFYHPLFYNGPIMTYKDFSEQIERPLCKVSALHVFSGILRLCVWWCLAEFMIHFMYMHAIQSNETYLEMLPPWAMGGLALALVQFFYVKYLVLFGAVSLLVRLDGLEPPTLPRCVSIMYSFTGMWRHFDVGLYKWLIRYIYVPLGGSRHGAFRKLLSTALAFGFVCFWHGCHDYLLYWALLNWVGVLVENAFALLFSSPPLRHAIVYCLTPRMQRRGLALISAFSTAFLILSNLFFLGGTHVGRIFWKKLFVQDWSSVAVPMVAFLYCFAQVGIEWDMR", "length": 508 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5VTY9-1", "protein_name": "Protein-cysteine N-palmitoyltransferase HHAT", "gene_name": "HHAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYATD", "length": 493 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMT9-1", "protein_name": "Protein-cysteine N-palmitoyltransferase HHAT", "gene_name": "Hhat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL", "length": 499 }, "evidence": [ { "id": "A0AAA9T5F1", "url": "https://omabrowser.org/oma/group/A0AAA9T5F1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "palmitoyltransferase activity", "id": "GO:0016409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5F1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5F1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6P3-1", "uniprot_ac": "A0AAA9T6P3", "uniprot_id": "A0AAA9T6P3_BOVIN", "mass": { "chemical_mass": 25331.0, "monoisotopic_mass": 25331.0 }, "refseq": { "ac": "XP_005207134", "name": "killer cell lectin-like receptor subfamily F member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207134" }, "gene_names": [ { "name": "KLRF1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ] }, { "name": "KLRF1", "type": "synonym", "evidence": [ { "id": "XP_005207134", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207134" } ] } ], "protein_names": [ { "name": "Killer cell lectin like receptor F1", "type": "synonym", "evidence": [ { "id": "A0AAA9T6P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#names_and_taxonomy" } ] }, { "name": "killer cell lectin-like receptor subfamily F member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005207134", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207134" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLRF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3", "locus": { "chromosome": "5", "start_pos": 100227914, "end_pos": 100238521, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037534", "url": "https://www.ensembl.org/id/ENSBTAG00000037534" } ] } } ], "crossref": [ { "id": "A0AAA9T6P3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6P3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd03593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613393", "url": "https://www.ncbi.nlm.nih.gov/gene/613393", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051379", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051379", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46746", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46746", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46746:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46746:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005207134", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207134", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRN5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QL15", "url": "https://www.uniprot.org/uniprotkb/F6QL15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QL15-1", "url": "https://www.uniprot.org/uniprotkb/F6QL15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRNALSKLIYVINLLDCSVMSHRYKILLGISGGLNGILVLTLITLSLLVSQEVLPKCLKQYNSNITQHDDTGYLEVNSDTRGNIHKKDADHCVSRATGHKGMCSSEWLKYQEKCYWFSNEMKNWSDSYKYCLGEKSHLLIIQNQLELAFIQKTLKQSNYVWIGLNFTSLKRTWTWVDDSPLDSKIFFIKGPAQENSCAAVKENGIYSETCSSVFKWICQY", "length": 221, "header": "tr|A0AAA9T6P3-1|A0AAA9T6P3_BOVIN Isoform 1 of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#A0AAA9RYB8-1", "sequence": { "sequence": "MQDEEIYMTLNTQLKKRSSIQTFQFKCQDCSVMSHRYKILLGISGGLNGILVLTLITLSLLGMCSSEWLKYQEKCYWFSNEMKNWSDSYKYCLGEKSHLLIIQNQLELAFIQKTLKQSNYVWIGLNFTSLKRTWTWVDDSPLDSKIFFIKGPAQENSCAAVKENGIYSETCSSVFKWICQY", "length": 181, "header": "tr|A0AAA9RYB8-1|A0AAA9T6P3_BOVIN Computationally mapped isoform of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "locus": { "chromosome": "5", "start_pos": 100238336, "end_pos": 100228201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074814.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074814.1" } ] } }, { "isoform_ac": "A0AAA9T6P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#A0AAA9T6P3-1", "sequence": { "sequence": "MSRNALSKLIYVINLLDCSVMSHRYKILLGISGGLNGILVLTLITLSLLVSQEVLPKCLKQYNSNITQHDDTGYLEVNSDTRGNIHKKDADHCVSRATGHKGMCSSEWLKYQEKCYWFSNEMKNWSDSYKYCLGEKSHLLIIQNQLELAFIQKTLKQSNYVWIGLNFTSLKRTWTWVDDSPLDSKIFFIKGPAQENSCAAVKENGIYSETCSSVFKWICQY", "length": 221, "header": "tr|A0AAA9T6P3-1|A0AAA9T6P3_BOVIN Isoform 1 of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "locus": { "chromosome": "5", "start_pos": 100238259, "end_pos": 100228201, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094431.1" } ] } }, { "isoform_ac": "A0AAA9TBD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#A0AAA9TBD2-1", "sequence": { "sequence": "MQDEEIYMTLNTQLKKRSSIQTFQFKCQDCSVMSHRYKILLGISGGLNGILVLTLITLSLLVSQEVLPKCLKQYNSNITQHDDTGYLEVNSDTRGNIHKKDADHCVSRATGHKDFS", "length": 116, "header": "tr|A0AAA9TBD2-1|A0AAA9TBD2_BOVIN Computationally mapped isoform of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "locus": { "chromosome": "5", "start_pos": 100238336, "end_pos": 100228299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096028.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096028.1" } ] } }, { "isoform_ac": "A0AAA9TRN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#A0AAA9TRN5-1", "sequence": { "sequence": "MQDEEIYMTLNTQLKKRSSIQTFQFKCQDCSVMSHRYKILLGISGGLNGILVLTLITLSLLDFS", "length": 64, "header": "tr|A0AAA9TRN5-1|A0AAA9TRN5_BOVIN Computationally mapped isoform of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "locus": { "chromosome": "5", "start_pos": 100238336, "end_pos": 100228299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120450.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120450.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099693.1" } ] } }, { "isoform_ac": "F6QL15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3/entry#F6QL15-1", "sequence": { "sequence": "MQDEEIYMTLNTQLKKRSSIQTFQFKCQDCSVMSHRYKILLGISGGLNGILVLTLITLSLLVSQEVLPKCLKQYNSNITQHDDTGYLEVNSDTRGNIHKKDADHCVSRATGHKGFYTENSKTIKLCVDWA", "length": 130, "header": "tr|F6QL15-1|F6QL15_BOVIN Computationally mapped isoform of Killer cell lectin like receptor F1 OS=Bos taurus OX=9913 GN=KLRF1 PE=4 SV=1 CANONICAL=A0AAA9T6P3-1" }, "locus": { "chromosome": "5", "start_pos": 100238336, "end_pos": 100231059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042955.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042955.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040557.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040557.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "NK T cell activation", "id": "GO:0051132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051132", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P3" }, { "id": "PS50041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C-type lectin", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 220, "start_aa": "Tyr", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T686-1", "uniprot_ac": "A0AAA9T686", "uniprot_id": "A0AAA9T686_BOVIN", "mass": { "chemical_mass": 82720.0, "monoisotopic_mass": 82720.0 }, "refseq": { "ac": "XP_059731996", "name": "intraflagellar transport protein 81 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731996" }, "gene_names": [ { "name": "IFT81", "type": "recommended", "evidence": [ { "id": "A0AAA9T686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ] }, { "name": "IFT81", "type": "synonym", "evidence": [ { "id": "XP_059731996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731996" } ] } ], "protein_names": [ { "name": "Intraflagellar transport protein 81 homolog", "type": "recommended", "evidence": [ { "id": "A0AAA9T686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#names_and_taxonomy" } ] }, { "name": "Carnitine deficiency-associated protein expressed in ventricle 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#names_and_taxonomy" } ] }, { "name": "intraflagellar transport protein 81 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731996", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731996" } ] } ], "function": [ { "annotation": "Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LJV4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJV4#function" }, { "database": "UniProtKB", "id": "ARBA00055755", "url": "https://www.uniprot.org/uniprotkb/ARBA00055755#function" }, { "database": "UniProtKB", "id": "A0AAA9RZU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU6#function" }, { "database": "UniProtKB", "id": "A0AAA9S800", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S800#function" }, { "database": "UniProtKB", "id": "A0A3Q1MQQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ9#function" }, { "database": "UniProtKB", "id": "F6RS05", "url": "https://www.uniprot.org/uniprotkb/F6RS05#function" }, { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IFT81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686", "locus": { "chromosome": "17", "start_pos": 54198874, "end_pos": 54063522, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020584", "url": "https://www.ensembl.org/id/ENSBTAG00000020584" } ] } } ], "crossref": [ { "id": "A0AAA9T686", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T686", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020584", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020584", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519602", "url": "https://www.ncbi.nlm.nih.gov/gene/519602", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041146", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041146", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519602", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519602", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR15614", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15614", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15614:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15614:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF18383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731996", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731996", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJV4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQQ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S800", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S800", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S800-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S800-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T686-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RS05", "url": "https://www.uniprot.org/uniprotkb/F6RS05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RS05-1", "url": "https://www.uniprot.org/uniprotkb/F6RS05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPIIKELRQLRQKCQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQFQMMRLVLESQIEKGNGSPLQYSCLENPMDQGAWWATSQT", "length": 704, "header": "tr|A0AAA9T686-1|A0AAA9T686_BOVIN Isoform 1 of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=1 CANONICAL=A0AAA9T686-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#A0A3Q1LJV4-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPIIKELRQLRQKCQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQLPVQ", "length": 668, "header": "tr|A0A3Q1LJV4-1|A0A3Q1LJV4_BOVIN Computationally mapped isoform of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=2 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54198779, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068214.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068214.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056850.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056850.2" } ] } }, { "isoform_ac": "A0A3Q1MQQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#A0A3Q1MQQ9-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPIIKELRQLRQKCQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQVIQEGGEDRLIL", "length": 639, "header": "tr|A0A3Q1MQQ9-1|A0A3Q1MQQ9_BOVIN Computationally mapped isoform of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=1 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54161195, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069082.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069082.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074370.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074370.2" } ] } }, { "isoform_ac": "A0AAA9RZU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#A0AAA9RZU6-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQVIQEGGEDRLIL", "length": 646, "header": "tr|A0AAA9RZU6-1|A0AAA9T686_BOVIN Computationally mapped isoform of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=1 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54161195, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095051.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095051.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079125.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079125.1" } ] } }, { "isoform_ac": "A0AAA9S800-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#A0AAA9S800-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEIR", "length": 398, "header": "tr|A0AAA9S800-1|A0AAA9T686_BOVIN Computationally mapped isoform of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=1 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54106243, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099080.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099080.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082164.1" } ] } }, { "isoform_ac": "A0AAA9T686-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#A0AAA9T686-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPIIKELRQLRQKCQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQFQMMRLVLESQIEKGNGSPLQYSCLENPMDQGAWWATSQT", "length": 704, "header": "tr|A0AAA9T686-1|A0AAA9T686_BOVIN Isoform 1 of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=1 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54174729, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125754.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125754.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091294.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091294.1" } ] } }, { "isoform_ac": "F6RS05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686/entry#F6RS05-1", "sequence": { "sequence": "MSDQIKFIVDNLNKEPFRKNYNLITFDSLEPMQLLQVLNDVLAEIDPKQVVDIREEMPEQTAKRMLSLLGILKYKPPGNAADMSTFRQGLVIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEDLMEAFKTLHKECEQLKISGFSTAEIRRDISAMEEEKDQLIKRVERLKKRVETVQNHQRMLKIARQLRVEKEREEFLAQQKQEQKNQLFHAVQRLQRIQNQLKSMRHAAADATPESLMKRLEEEIKFNSYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTQINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAEELQEAKEKLANLEREVSVKTSQTREYDGTEVLKGDEFKRYVSKLRSKSTVFKKKHQIIAEFKAEFGLLQRTEELLKQRHENIQHQLQTIEEKRGISGYSYTQEELERVSALKSEVDEMKGRTLDDMSEMVKKLNSLVSEKKSALAPIIKELRQLRQKCQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRGLREECLQEESRYHYINCMIKNLEVQLRRATDEMKAYVSSDQQEKRKAIREQYTKNIAEQENLGKKLREKQKAVRESHGPNMKQAKMWHDFEQLMECKKQCFLKQQTQTSIGQANKTWCTYH", "length": 673, "header": "tr|F6RS05-1|F6RS05_BOVIN Computationally mapped isoform of Intraflagellar transport protein 81 homolog OS=Bos taurus OX=9913 GN=IFT81 PE=3 SV=2 CANONICAL=A0AAA9T686-1" }, "locus": { "chromosome": "17", "start_pos": 54161750, "end_pos": 54068706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027427.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027427.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027427.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027427.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519602", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519602", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "intraciliary transport particle B", "id": "GO:0030992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030992", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "intraciliary transport", "id": "GO:0042073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042073", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "regulation of smoothened signaling pathway", "id": "GO:0008589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "intraciliary transport involved in cilium assembly", "id": "GO:0035735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035735", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" }, { "name": "sperm flagellum assembly", "id": "GO:0120316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120316", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T686", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 542, "end_pos": 544, "annotation": "n_glycosylation_sequon" }, { "start_pos": 680, "end_pos": 682, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T686" }, { "id": "PF18383", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18383" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT81 calponin homology", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 126, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 542, "end_pos": 544 }, { "start_pos": 680, "end_pos": 682 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5I6-1", "uniprot_ac": "A0AAA9T5I6", "uniprot_id": "A0AAA9T5I6_BOVIN", "mass": { "chemical_mass": 74763.0, "monoisotopic_mass": 74763.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF432", "type": "recommended", "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ] }, { "name": "ZNF613", "type": "recommended", "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ] }, { "name": "ZNF613", "type": "synonym", "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ] } ], "protein_names": [ { "name": "Zinc finger protein 613", "type": "synonym", "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF613", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6", "locus": { "chromosome": "18", "start_pos": 57832753, "end_pos": 57807061, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038487", "url": "https://www.ensembl.org/id/ENSBTAG00000038487" } ] } } ], "crossref": [ { "id": "A0AAA9T5I6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5I6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006954", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006954", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539365", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539365", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HEDFHSA", "url": "https://omabrowser.org/oma/group/HEDFHSA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MS92", "url": "https://www.orthodb.org/?gene=F1MS92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24379:SF122", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24379:SF122", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S0D5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS92", "url": "https://www.uniprot.org/uniprotkb/F1MS92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS92-1", "url": "https://www.uniprot.org/uniprotkb/F1MS92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PW10", "url": "https://www.uniprot.org/uniprotkb/F6PW10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PW10-1", "url": "https://www.uniprot.org/uniprotkb/F6PW10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPQQEILSFKDVAVDFTWEEWQLLTPAQKTLYRDVMLENYSNLVSVVSKSDVLFKLEQGEERWMTEDEIHSHTWPETGNIGNHLQVDWENKKMLKGIEQYQERNTFGNPVLQSQSYFCFRQNHDMFEFYIKTLKTNSSLVIQSQSYEIKNSAKCNGDGKSFLFGKHEKCHSPVKCPVSAKPISTKSQVIKHQITHNIEKAHICSECGKAFVKKSQLTDHQRVHTGEKPYGCNLCAKVFSRKSRLNEHQRIHEREKSFICSDCGKVFITKSRLIEHQRTHTGEKPYVCSDCGKGFPGKRNLILHQRNHTGEKSYVCSECGKGFTAKSMLTIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFIMKSRLTEHQRIHTGEKPYMCNECGKGFSRKGNLIVHQKTHTVEKSYVCSECGKGFTLKSMLTVHQRTHTGEKPYICSECGKGFPLKSRLVVHQRTHTGEKPYRCSECGKGFVVNSALMIHQRTHTGEKPYTCNECGKEFAFKSNLVVHQRTHTGEKPFTCSECGKGFTMKRYLIVHQQIHMGEKSYICSECGKGFVMETELILHQQIHTGEKPYACSECGKGFFVKSRLVVHQRTHTGEKPFVCSDCGKGFSSKRNLLVHQRTHNGNKPLKR", "length": 652, "header": "tr|A0AAA9T5I6-1|A0AAA9T5I6_BOVIN Isoform 1 of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0D5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#A0AAA9S0D5-1", "sequence": { "sequence": "MSLLLAKLHTVYFLKYNSTLADHNPSQEPICLISHEQGIKPASQLLSPDWNEENCGPWKTKSTVESVQEILSFKDVAVDFTWEEWQLLTPAQKTLYRDVMLENYSNLVSVAPAQFSGTKSSIISHKRYRVSKSDVLFKLEQGEERWMTEDEIHSHTWPETGNIGNHLQVDWENKKMLKGIEQYQERNTFGNPVLQSQSYFCFRQNHDMFEFYIKTLKTNSSLVIQSQSYEIKNSAKCNGDGKSFLFGKHEKCHSPVKCPVSAKPISTKSQVIKHQITHNIEKAHICSECGKAFVKKSQLTDHQRVHTGEKPYGCNLCAKVFSRKSRLNEHQRIHEREKSFICSDCGKVFITKSRLIEHQRTHTGEKPYVCSDCGKGFPGKRNLILHQRNHTGEKSYVCSECGKGFTAKSMLTIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFIMKSRLTEHQRIHTGEKPYMCNECGKGFSRKGNLIVHQKTHTVEKSYVCSECGKGFTLKSMLTVHQRTHTGEKPYICSECGKGFPLKSRLVVHQRTHTGEKPYRCSECGKGFVVNSALMIHQRTHTGEKPYTCNECGKEFAFKSNLVVHQRTHTGEKPFTCSECGKGFTMKRYLIVHQQIHMGEKSYICSECGKGFVMETELILHQQIHTGEKPYACSECGKGFFVKSRLVVHQRTHTGEKPFVCSDCGKGFSSKRNLLVHQRTHNGNKPLKR", "length": 734, "header": "tr|A0AAA9S0D5-1|A0AAA9T5I6_BOVIN Computationally mapped isoform of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57831749, "end_pos": 57809414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090914.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090914.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078422.1" } ] } }, { "isoform_ac": "A0AAA9S4M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#A0AAA9S4M2-1", "sequence": { "sequence": "MIKDQRSLTLEDVAVDFTWEEWQLLAPPQKALYRDVMLENYSNLVSVGYQASKPAALSRLERGELWPVEDKVHSRICPEMRKDDCLLQENLQNQSCPKRMERCHEHNALGNVYQSKNHCPLWQNHDVLYLHGKTLKSNLSSISQNRNYEVKNPVKANVNGKFFLHAKHEEFHSESKLPECGIPMNTNSQIITCLGTQQINKPHVCTECGKAFIKKSRLIDHQRVHTGEKPHRCSVCGKAFSRKSRLNEHQKTHIGEKQYACNECDKVFPKKSRLLIHQKTHTGEKPYICDDCGKGFVKKSRLINHQRVHTGEKPHGCSLCDKAFSRKSRLMEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKTHTGEKSYICSDCGKGFIQKGNLIVHQRTHTGEKPYVCTECGKGFIQKGNLLIHQRTHTGEKPYVCTECGKGFSQKTCLISHQRFHTGKTPFVCTECGKSCSHKSGLINHQRIHTGEKPYTCNDCGKAFRDKSCLNRHRRIHTGERPYGCNDCGKAFSHLSCLVYHKGMLHAREKRGDSVKLEDAFSKHLSPSHPSDMVQRKSPVSVVTVQMPSVAVQTPSHSNKPLEDKNIPLVGQLGGRYAPSAGLTNRQDMNKEREGSRT", "length": 626, "header": "tr|A0AAA9S4M2-1|A0AAA9T5I6_BOVIN Computationally mapped isoform of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57825346, "end_pos": 57807256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123282.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123282.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080121.1" } ] } }, { "isoform_ac": "A0AAA9SEE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#A0AAA9SEE2-1", "sequence": { "sequence": "MIKDQRSLTLEDVAVDFTWEEWQLLAPPQKALYRDVMLENYSNLVSVGYQASKPAALSRLERGELWPVEDKVHSRICPEMRKDDCLLQENLQNQSCPKRMERCHEHNALGNVYQSKNHCPLWQNHDVLYLHGKTLKSNLSSISQNRNYEVKNPVKANVNGKFFLHAKHEEFHSESKLPECGIPMNTNSQIITCLGTQQINKPHVCTECGKAFIKKSRLIDHQRVHTGEKPHRCSVCGKAFSRKSRLNEHQKTHIGEKQYACNECDKVFPKKSRLLIHQKTHTGEKPYICDDCGKGFVKKSRLINHQRVHTGEKPHGCSLCDKAFSRKSRLMEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKTHTGEKSYICSDCGKGFIQKGNLIVHQRTHTGEKPYVCTECGKGFSQKTCLISHQRFHTGKTPFVCTECGKSCSHKSGLINHQRIHTGEKPYTCNDCGKAFRDKSCLNRHRRIHTGERPYGCNDCGKAFSHLSCLVYHKGMLHAREKRGDSVKLEDAFSKHLSPSHPSDMVQRKSPVSVVTVQMPSVAVQTPSHSNKPLEDKNIPLVGQLGGRYAPSAGNRIRTEEKPSECGSTLSGQLCHIFVTKDTQE", "length": 613, "header": "tr|A0AAA9SEE2-1|A0AAA9T5I6_BOVIN Computationally mapped isoform of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57816022, "end_pos": 57807256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124820.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124820.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081956.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081956.1" } ] } }, { "isoform_ac": "A0AAA9T5I6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#A0AAA9T5I6-1", "sequence": { "sequence": "MHPQQEILSFKDVAVDFTWEEWQLLTPAQKTLYRDVMLENYSNLVSVVSKSDVLFKLEQGEERWMTEDEIHSHTWPETGNIGNHLQVDWENKKMLKGIEQYQERNTFGNPVLQSQSYFCFRQNHDMFEFYIKTLKTNSSLVIQSQSYEIKNSAKCNGDGKSFLFGKHEKCHSPVKCPVSAKPISTKSQVIKHQITHNIEKAHICSECGKAFVKKSQLTDHQRVHTGEKPYGCNLCAKVFSRKSRLNEHQRIHEREKSFICSDCGKVFITKSRLIEHQRTHTGEKPYVCSDCGKGFPGKRNLILHQRNHTGEKSYVCSECGKGFTAKSMLTIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFIMKSRLTEHQRIHTGEKPYMCNECGKGFSRKGNLIVHQKTHTVEKSYVCSECGKGFTLKSMLTVHQRTHTGEKPYICSECGKGFPLKSRLVVHQRTHTGEKPYRCSECGKGFVVNSALMIHQRTHTGEKPYTCNECGKEFAFKSNLVVHQRTHTGEKPFTCSECGKGFTMKRYLIVHQQIHMGEKSYICSECGKGFVMETELILHQQIHTGEKPYACSECGKGFFVKSRLVVHQRTHTGEKPFVCSDCGKGFSSKRNLLVHQRTHNGNKPLKR", "length": 652, "header": "tr|A0AAA9T5I6-1|A0AAA9T5I6_BOVIN Isoform 1 of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57831749, "end_pos": 57815913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091829.1" } ] } }, { "isoform_ac": "F1MS92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#F1MS92-1", "sequence": { "sequence": "MIQAQDVAVDFTWEEWQLLTPAQKTLYRDVMLENYSNLVSVAPAQFSGTKSSIISHKRYRVSKSDVLFKLEQGEERWMTEDEIHSHTWPETGNIGNHLQVDWENKKMLKGIEQYQERNTFGNPVLQSQSYFCFRQNHDMFEFYIKTLKTNSSLVIQSQSYEIKNSAKCNGDGKSFLFGKHEKCHSPVKCPVSAKPISTKSQVIKHQITHNIEKAHICSECGKAFVKKSQLTDHQRVHTGEKPYGCNLCAKVFSRKSRLNEHQRIHEREKSFICSDCGKVFITKSRLIEHQRTHTGEKPYVCSDCGKGFPGKRNLILHQRNHTGEKSYVCSECGKGFTAKSMLTIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFIMKSRLTEHQRIHTGEKPYMCNECGKGFSRKGNLIVHQKTHTVEKSYVCSECGKGFTLKSMLTVHQRTHTGEKPYICSECGKGFPLKSRLVVHQRTHTGEKPYRCSECGKGFVVNSALMIHQRTHTGEKPYTCNECGKEFAFKSNLVVHQRTHTGEKPFTCSECGKGFTMKRYLIVHQQIHMGEKSYICSECGKGFVMETELILHQQIHTGEKPYACSECGKGFFVKSRLVVHQRTHTGEKPFVCSDCGKGFSSKRNLLVHQRTHNGNKPLKR", "length": 665, "header": "tr|F1MS92-1|A0AAA9T5I6_BOVIN Computationally mapped isoform of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=4 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57831749, "end_pos": 57825465, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031814.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031814.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031760.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031760.6" } ] } }, { "isoform_ac": "F6PW10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6/entry#F6PW10-1", "sequence": { "sequence": "VLLQRSLTLEDVAVDFTWEEWQLLAPPQKALYRDVMLENYSNLVSVGYQASKPAALSRLERGELWPVEDKVHSRICPEMRKDDCLLQENLQNQSCPKRMERCHEHNALGNVYQSKNHCPLWQNHDVLYLHGKTLKSNLSSISQNRNYEVKNPVKANVNGKFFLHAKHEEFHSESKLPECGIPMNTNSQIITCLGTQQINKPHVCTECGKAFIKKSRLIDHQRVHTGEKPHRCSVCGKAFSRKSRLNEHQKTHIGEKQYACNECDKVFPKKSRLLIHQKTHTGEKPYICDDCGKGFVKKSRLINHQRVHTGEKPHGCSLCDKAFSRKSRLMEHQRTHTGEKPYECTECDKAFRWKSQLNAHQKTHTGEKSYICSDCGKGFIQKGNLIVHQRTHTGEKPYVCTECGKGFIQKGNLLIHQRTHTGEKPYVCTECGKGFSQKTCLISHQRFHTGKTPFVCTECGKSCSHKSGLINHQRIHTGEKPYTCNDCGKAFRDKSCLNRHRRIHTGERPYGCNDCGKAFSHLSCLVYHKGMLHAREKRGDSVKLEDAFSKHLSPSHPSDMVQRKSPVSVVTVQMPSVAVQTPSHSNKPLEDKNIPLVGQLGGRYAPSAGNRIRTEEKPSECGSTLSGQLCHIFVTKDTQE", "length": 640, "header": "tr|F6PW10-1|F6PW10_BOVIN Computationally mapped isoform of Zinc finger protein 613 OS=Bos taurus OX=9913 GN=ZNF613 PE=3 SV=1 CANONICAL=A0AAA9T5I6-1" }, "locus": { "chromosome": "18", "start_pos": 57816022, "end_pos": 57809104, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052047.5", "url": "https://www.ensembl.org/id/ENSBTAT00000052047.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047664.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047664.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539365", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RNL1-1", "protein_name": "Zinc finger protein 432", "gene_name": "ZNF432", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIQAQGSLSFRDVAVDFTWEEWQLLTPAQKDLFRDVTLENYRNLVAVAGYQVSKPAALAKLERREEPWTRAEEAPSGTCEETGKIGNQLPGDWENQRMLKGIDQYQEYNALGNPVPQSKSHFPFRQNSDMLEFYIKTLKSNLILVSQSQSYDIKNSTECNGDGKSFLHAKHEEFHLAVKCPVSAKPISNKSQNIKHQRTHNTEKTHVCSECGKAFVKKSQLTDHQRVHTGEKPYGCSMCTKVFSRKSRLNEHQRIHKREKSFICSDCGKVFTMKSRLIEHQRTHTGEKPYVCNECGKGFPGKRNLIVHQRNHTGEKCYVCGECGKGFTGKSMLTIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNDCGKGFTMKCRLIEHQRTHTGEKPYVCPECGKGFPRKSNLIVHQRNHTVEKSYVCSECGKGFTVKSMLIIHQRTHTGEKPYICSECGKGFPLKSRLVVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNKCGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLVVHQQIHTGEKSYICRECGKGFVTETELILHQQTHTGEKPFACNECGKGFTVKSRLVVHQRTHTGEKPFVCSECGKAFSSKRNLIVHQRTHNGNKP", "length": 653 }, "evidence": [ { "id": "A0AAA9T5I6", "url": "https://omabrowser.org/oma/group/A0AAA9T5I6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O94892-1", "protein_name": "Zinc finger protein 432", "gene_name": "ZNF432", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNLLSMGYQVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTASQTKSLCLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFSVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNECGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECGRGFAKETELALHKQVHTGEKPYGCNECGKGFTMKSRLIVHQRTHTGEKPFVCSECRKAFSSKRNLIVHQRTHNGNKP", "length": 652 }, "evidence": [ { "id": "A0AAA9T5I6", "url": "https://omabrowser.org/oma/group/A0AAA9T5I6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5I6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 202, "end_pos": 229, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T5I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5I6" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 8, "end_pos": 76, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 40, "end_pos": 42 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6Q9-1", "uniprot_ac": "A0AAA9T6Q9", "uniprot_id": "A0AAA9T6Q9_BOVIN", "mass": { "chemical_mass": 80669.0, "monoisotopic_mass": 80669.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF420", "type": "recommended", "evidence": [ { "id": "A0AAA9T6Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ] }, { "name": "ZNF461", "type": "recommended", "evidence": [ { "id": "A0AAA9T6Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ] }, { "name": "ZNF420", "type": "synonym", "evidence": [ { "id": "A0AAA9T6Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ] } ], "protein_names": [ { "name": "Zinc finger protein 420", "type": "recommended", "evidence": [ { "id": "A0AAA9T6Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#names_and_taxonomy" } ] } ], "function": [ { 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"https://omabrowser.org/oma/group/TFEYKEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAE9", "url": "https://www.orthodb.org/?gene=E1BAE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MML9", "url": "https://www.orthodb.org/?gene=F1MML9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19818:SF158", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19818:SF158", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0G0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0G0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4I9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4I9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4I9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4I9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAE9", "url": "https://www.uniprot.org/uniprotkb/E1BAE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAE9-1", "url": "https://www.uniprot.org/uniprotkb/E1BAE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MML9", "url": "https://www.uniprot.org/uniprotkb/F1MML9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MML9-1", "url": "https://www.uniprot.org/uniprotkb/F1MML9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRGLRPWRSLAWLPQGGRTRNRAGTPGTRSWALNCTLYRAPRGRKNDCCTVRSKLQDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 699, "header": "tr|A0AAA9T6Q9-1|A0AAA9T6Q9_BOVIN Isoform 1 of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF420 PE=4 SV=1 CANONICAL=A0AAA9T6Q9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#A0AAA9S0G0-1", "sequence": { "sequence": "MSHSSKNHGSDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 652, "header": "tr|A0AAA9S0G0-1|A0AAA9T6Q9_BOVIN Computationally mapped isoform of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF420 PE=4 SV=1 CANONICAL=A0AAA9T6Q9-1" }, "locus": { "chromosome": "18", "start_pos": 47512998, "end_pos": 47497026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109268.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109268.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075547.1" } ] } }, { "isoform_ac": "A0AAA9T6Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#A0AAA9T6Q9-1", "sequence": { "sequence": "MGRGLRPWRSLAWLPQGGRTRNRAGTPGTRSWALNCTLYRAPRGRKNDCCTVRSKLQDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 699, "header": "tr|A0AAA9T6Q9-1|A0AAA9T6Q9_BOVIN Isoform 1 of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF420 PE=4 SV=1 CANONICAL=A0AAA9T6Q9-1" }, "locus": { "chromosome": "18", "start_pos": 47523161, "end_pos": 47497026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134599.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134599.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091469.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091469.1" } ] } }, { "isoform_ac": "A0ABI0P4I9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#A0ABI0P4I9-1", "sequence": { "sequence": "MEKSCRASIPSPGDLPDPGMEPTSPALADLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 670, "header": "tr|A0ABI0P4I9-1|A0ABI0P4I9_BOVIN Computationally mapped isoform of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF420 PE=4 SV=1 CANONICAL=A0AAA9T6Q9-1" }, "locus": { "chromosome": "18", "start_pos": 47499527, "end_pos": 47497026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152377.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152377.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106345.1" } ] } }, { "isoform_ac": "E1BAE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#E1BAE9-1", "sequence": { "sequence": "MEKSCRASIPSPDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 654, "header": "tr|E1BAE9-1|E1BAE9_BOVIN Computationally mapped isoform of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF461 PE=4 SV=4 CANONICAL=A0AAA9T6Q9-1" }, "locus": { "chromosome": "18", "start_pos": 47499527, "end_pos": 47497026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055644.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055644.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049362.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049362.4" } ] } }, { "isoform_ac": "F1MML9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9/entry#F1MML9-1", "sequence": { "sequence": "MAQRSVMFRDVAIDFSQEEWDCLDSAQRDLYRDVMLENYSNLVSLDLPSRGANKLLSPKKDIYETGLSQWEMSARLENCDLENSSSRDHLEVKGTLEKQQENQAYFSQGMIIYDNMSIFNQHAYLSQHPRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECQECGKAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYGCKECGKAFSHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCRECGKAFTRGSQLTQHQRIHISEKSFAYKECGIDFSHDSQVYI", "length": 687, "header": "tr|F1MML9-1|A0AAA9T6Q9_BOVIN Computationally mapped isoform of Zinc finger protein 420 OS=Bos taurus OX=9913 GN=ZNF420 PE=4 SV=1 CANONICAL=A0AAA9T6Q9-1" }, "locus": { "chromosome": "18", "start_pos": 47512976, "end_pos": 47497026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054598.2", "url": "https://www.ensembl.org/id/ENSBTAT00000054598.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000049685.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7H8H1-1", "protein_name": "Zinc finger protein 420", "gene_name": "LOC103161318", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAHVMTFRDVAIDFSPEEWECLTLEQRHLYRDVMLENYSHLVSVGLCIYQPHEFPVLAKEQDAFMDLGSEGRRFCPDIDPVWRKNKVLPKDSTRAGQLSQWEVLETDTNHSLEGLCPRADWEGKGQVPTPRETQEECFKQMTLTYEKLLMAFNQCPRLHIEEKASGFKSEKSFSFAEDPTQPQLIHTGEQSEDDKKCGKTFPPGSKLTRCRAVHPGKKAFQCEECGKAFSFRSSLTGHKRIHTGEKPFKCKECGKAFRFHSLLSVHVRIHTGEKSYECKECGKYFNYSSDLTRHHRIHTGEKPYQCRQCGKAFSCGSDLTRHERIHTGEKPYECNECGKAFIQQSHLIKHQRTHTGEKPYVCKECGKAFTCGSQLSQHKKIHTGDKLHKCKECKNSFSFALDHTQRQLIYIGEKFFEDKENGKTFFPDSKLAGFQTVHAGKKIYGCKECGKTFTLRSIVSSLKKIHNREKLFKCKDCEKAFRCPSDLSRHQKIHTGEKPYKCKECGKGFICRSDLGRHQRVHTGVKPYVCKECGKAFTRGAHLTQHQKSHSKKSHELSGGDKAFCCKECPKAFRYSSELTRHQRLHTGEKPYKCQDCWKAFASASDLARHQRIHTGERPYECSECGKAFIQQSHLIKHQRIHTGKKPYKCEECGKAFRRASHLTQHQSVHTGEKPYECEQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCDECGKTFIRSSQLSRHQKVHTGEKPFECKACGKAFPQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLLLHRRSHTGEKPYECKECGKAFICASQLSQHQKIHNGEKPYECKECGKAFIRGSLLMQHQRIHTGEKPYKCDDCGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYDCKECGKNFSRGSELTQHERIHTGEKPYECKECGKSFIRSSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYRCRECGKAFIRGSQLTQHQRTHTGEKPYECKECGKAFGHGSQLTLHQRIHTGEKPYECKECRKAFTQSSHLSRHQRIHTGEKPYQCKECEKAFTRGSQLMQHQRIHSSDKSVDCKECGIDFSHHSQFFI", "length": 1197 }, "evidence": [ { "id": "A0AAA9T6Q9", "url": "https://omabrowser.org/oma/group/A0AAA9T6Q9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3Z901-1", "protein_name": "Zinc finger protein 420", "gene_name": "LOC134478826", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MITHDKMSIFSPGTHLPQHPQGYSTEKPYKCEECGKAFRRASHLSQHHSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYTCKECGKAFTQSSQLILHHRIHTGEKPYKCEACGKAFIRSSQLSRHQKVHTGEKPFECKECGKAFTQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLILHRRIHTGEKPYECKECGKAFICGSQLSQHQKTHNGEKPYECKECGKAFIRGSLLMQHQRIHTGEKPYKCDECGKAFIRGSQLTQHQRIHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYKCKECGKDFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYECRECGKAFIRGSQLTQHQRTHTGEKPYECRECGKAFGHGSQLTLHQRVHTGEKPYECKECRKAFAQSSHLSRHQRVHTGEKPYQCKECEKAFTRGSQLTQHQRIHISDKSFDCKECRIDLSHHSQIFI", "length": 578 }, "evidence": [ { "id": "A0AAA9T6Q9", "url": "https://omabrowser.org/oma/group/A0AAA9T6Q9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TAQ5-1", "protein_name": "Zinc finger protein 420", "gene_name": "ZNF420", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARKLVMFRDVAIDFSQEEWECLDSAQRDLYRDVMLENYSNLVSLDLPSRCASKDLSPEKNTYETELSQWEMSDRLENCDLEESNSRDYLEAKGKMEKQQENQKEYFRQGMIIYDKMSIFNQHTYLSQHSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSSQLILHHRIHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQLTLHQRLHTGEKLYECKECRKVFTQLSQLILHKRIHTGEKPYECKECGKAFICGSQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQHQRIHTGEKPYQCKECGKAFIRGSQLTQHQRIHTGEKPYECKECGKAFSHGSQLTLHQRIHTGEKPYECRECRKAFTQSSHLSRHQRIHTGEKPYQCKECGKAFTRGSQLTQHQRIHISEKSFEYKECGIDFSHGSQVYM", "length": 688 }, "evidence": [ { "id": "A0AAA9T6Q9", "url": "https://omabrowser.org/oma/group/A0AAA9T6Q9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 150, "end_pos": 177, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 35, "end_pos": 37 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T716-1", "uniprot_ac": "A0AAA9T716", "uniprot_id": "A0AAA9T716_BOVIN", "mass": { "chemical_mass": 102975.0, "monoisotopic_mass": 102975.0 }, "refseq": { "ac": "XP_024838659", "name": "metabotropic glutamate receptor 7 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838659" }, "gene_names": [ { "name": "GRM7", "type": "recommended", "evidence": [ { "id": "A0AAA9T716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ] }, { "name": "GRM7", "type": "synonym", "evidence": [ { "id": "XP_024838659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838659" } ] } ], "protein_names": [ { "name": "Glutamate metabotropic receptor 7", "type": "synonym", "evidence": [ { "id": "A0AAA9T716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716/entry#names_and_taxonomy" } ] }, { "name": "metabotropic glutamate receptor 7 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838659", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838659" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716", "locus": { "chromosome": "22", "start_pos": 18627109, "end_pos": 19567204, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013047", "url": "https://www.ensembl.org/id/ENSBTAG00000013047" } ] } } ], "crossref": [ { "id": "A0AAA9T716", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T716", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013047", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013047", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15451", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15451", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535362", "url": "https://www.ncbi.nlm.nih.gov/gene/535362", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017978", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017978", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038550", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038550", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050726", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050726", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535362", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535362", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BLE8", "url": "https://www.orthodb.org/?gene=E1BLE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00003", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00003", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838659", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T716-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLE8", "url": "https://www.uniprot.org/uniprotkb/E1BLE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLE8-1", "url": "https://www.uniprot.org/uniprotkb/E1BLE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQLGKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDKIIKQLLDTPNSRAVVLFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTMPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNNCIPPVRKSVQKSVTWYTIPPTV", "length": 922, "header": "tr|A0AAA9T716-1|A0AAA9T716_BOVIN Isoform 1 of Glutamate metabotropic receptor 7 OS=Bos taurus OX=9913 GN=GRM7 PE=3 SV=1 CANONICAL=A0AAA9T716-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716/entry#A0AAA9S0Y1-1", "sequence": { "sequence": "MVQLGKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDKIIKQLLDTPNSRAVVLFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTMPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI", "length": 915, "header": "tr|A0AAA9S0Y1-1|A0AAA9T716_BOVIN Computationally mapped isoform of Glutamate metabotropic receptor 7 OS=Bos taurus OX=9913 GN=GRM7 PE=3 SV=1 CANONICAL=A0AAA9T716-1" }, "locus": { "chromosome": "22", "start_pos": 19567204, "end_pos": 18628296, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119192.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119192.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076973.1" } ] } }, { "isoform_ac": "A0AAA9T716-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716/entry#A0AAA9T716-1", "sequence": { "sequence": "MVQLGKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDKIIKQLLDTPNSRAVVLFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTMPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNNCIPPVRKSVQKSVTWYTIPPTV", "length": 922, "header": "tr|A0AAA9T716-1|A0AAA9T716_BOVIN Isoform 1 of Glutamate metabotropic receptor 7 OS=Bos taurus OX=9913 GN=GRM7 PE=3 SV=1 CANONICAL=A0AAA9T716-1" }, "locus": { "chromosome": "22", "start_pos": 19567204, "end_pos": 18674537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098627.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098627.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091601.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091601.1" } ] } }, { "isoform_ac": "E1BLE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716/entry#E1BLE8-1", "sequence": { "sequence": "MVQLGKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDKIIKQLLDTPNSRAVVLFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTMPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSEKSDHSG", "length": 907, "header": "tr|E1BLE8-1|E1BLE8_BOVIN Computationally mapped isoform of Glutamate metabotropic receptor 7 OS=Bos taurus OX=9913 GN=GRM7 PE=3 SV=4 CANONICAL=A0AAA9T716-1" }, "locus": { "chromosome": "22", "start_pos": 19567204, "end_pos": 18666979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017342.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017342.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017342.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017342.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535362", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535362", "resource": "KEGG Pathway" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" }, { "id": "R-BTA-420499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420499", "resource": "Reactome", "description": "Class C/3 (Metabotropic glutamate/pheromone receptors)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "group III metabotropic glutamate receptor activity", "id": "GO:0001642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001642", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "adenylate cyclase inhibitor activity", "id": "GO:0010855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010855", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "serine binding", "id": "GO:0070905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "regulation of synaptic transmission, glutamatergic", "id": "GO:0051966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" }, { "name": "G protein-coupled glutamate receptor signaling pathway", "id": "GO:0007216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007216", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T716", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 572, "end_pos": 574, "annotation": "n_glycosylation_sequon" }, { "start_pos": 616, "end_pos": 618, "annotation": "n_glycosylation_sequon" }, { "start_pos": 830, "end_pos": 832, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T716" }, { "id": "PS50259", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50259" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 3 profile", "eco_id": "ECO_0000259", "start_pos": 590, "end_pos": 864, "start_aa": "Trp", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 458, "end_pos": 460 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 572, "end_pos": 574 }, { "start_pos": 616, "end_pos": 618 }, { "start_pos": 830, "end_pos": 832 }, { "start_pos": 98, "end_pos": 100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"mass": { "chemical_mass": 52360.0, "monoisotopic_mass": 52360.0 }, "refseq": { "ac": "XP_059735968", "name": "zinc finger protein 621-like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735968" }, "gene_names": [ { "name": "LOC132343483", "type": "recommended", "evidence": [ { "id": "A0AAA9T8K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ] }, { "name": "LOC132343483", "type": "synonym", "evidence": [ { "id": "XP_059735968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735968" } ] } ], "protein_names": [ { "name": "Zinc finger protein 621", "type": "recommended", "evidence": [ { "id": "A0AAA9T8K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 621-like isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059735968", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735968" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132343483", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1", "locus": {} } ], "crossref": [ { "id": "A0AAA9T8K1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8K1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "132343483", "url": "https://www.ncbi.nlm.nih.gov/gene/132343483", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:132343483", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132343483", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF260", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF260", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059735968", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735968", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T254", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T254", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T254-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T254-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRERLLRFLLFQTGKSAQSQGTSAMLQTTWPQEPVTFEDVAVYFTQNQWASLDSAQRALYREVMLENYANVASLVSPFPRPDLISQLERGEAPWDPDPWEAEDLRGICPGGERGIKTEEPAVAQQASEGTEAHSRPVGGLLTNVSQHLDFESKAVWQTFSLNPNLILRGGMKFYKCKECGKIFRYNSKLLRHQRSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGQGPYECKECGKGLSSNTALTQHQRIHTGEKPYACKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKGFGCRSLFIVHQRIHTGEKPYQCKECGKAFSQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKVHPVEKKPSKALGQPLLRPQGPSASLAPGCLPGPGSAPAVAVALPHAVLIPVSGPVFMLLPTSGVLSSPVQVVRVFQGLPPAVKSSPVILTPSPHPCDLSLGTSLTVTADL", "length": 473, "header": "tr|A0AAA9T8K1-1|A0AAA9T8K1_BOVIN Isoform 1 of Zinc finger protein 621 OS=Bos taurus OX=9913 GN=LOC132343483 PE=3 SV=1 CANONICAL=A0AAA9T8K1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2A0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1/entry#A0AAA9S2A0-1", "sequence": { "sequence": "MLQTTWPQEPVTFEDVAVYFTQNQWASLDSAQRALYREVMLENYANVASLVVSPFPRPDLISQLERGEAPWDPDPWEAEDLRGICPGGERGIKTEEPAVAQQASEGTEAHSRPVGGLLTNVSQHLDFESKAVWQTFSLNPNLILRGGMKFYKCKECGKIFRYNSKLLRHQRSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGQGPYECKECGKGLSSNTALTQHQRIHTGEKPYACKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKGFGCRSLFIVHQRIHTGEKPYQCKECGKAFSQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKVHPVEKKPSKALGQPLLRPQGPSASLAPGCLPGPGSAPAVAVALPHAVLIPVSGPVFMLLPTSGVLSSPVQVVRVFQGLPPAVKSSPVILTPSPHPCDLSLGTSLTVTADL", "length": 450, "header": "tr|A0AAA9S2A0-1|A0AAA9T8K1_BOVIN Computationally mapped isoform of Zinc finger protein 621 OS=Bos taurus OX=9913 GN=LOC132343483 PE=3 SV=1 CANONICAL=A0AAA9T8K1-1" }, "locus": { "chromosome": "22", "start_pos": 13371261, "end_pos": 13360950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076228.1" } ] } }, { "isoform_ac": "A0AAA9T254-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1/entry#A0AAA9T254-1", "sequence": { "sequence": "MLQTTWPQEPVTFEDVAVYFTQNQWASLDSAQRALYREVMLENYANVASLVSPFPRPDLISQLERGEAPWDPDPWEAEDLRGICPGGERGIKTEEPAVAQQASEGTEAHSRPVGGLLTNVSQHLDFESKAVWQTFSLNPNLILRGGMKFYKCKECGKIFRYNSKLLRHQRSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGQGPYECKECGKGLSSNTALTQHQRIHTGEKPYACKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKGFGCRSLFIVHQRIHTGEKPYQCKECGKAFSQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKVHPVEKKPSKALGQPLLRPQGPSASLAPGCLPGPGSAPAVAVALPHAVLIPVSGPVFMLLPTSGVLSSPVQVVRVFQGLPPAVKSSPVILTPSPHPCDLSLGTSLTVTADL", "length": 449, "header": "tr|A0AAA9T254-1|A0AAA9T8K1_BOVIN Computationally mapped isoform of Zinc finger protein 621 OS=Bos taurus OX=9913 GN=LOC132343483 PE=3 SV=1 CANONICAL=A0AAA9T8K1-1" }, "locus": { "chromosome": "22", "start_pos": 13371261, "end_pos": 13360950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118373.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118373.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091811.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091811.1" } ] } }, { "isoform_ac": "A0AAA9T8K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1/entry#A0AAA9T8K1-1", "sequence": { "sequence": "MRERLLRFLLFQTGKSAQSQGTSAMLQTTWPQEPVTFEDVAVYFTQNQWASLDSAQRALYREVMLENYANVASLVSPFPRPDLISQLERGEAPWDPDPWEAEDLRGICPGGERGIKTEEPAVAQQASEGTEAHSRPVGGLLTNVSQHLDFESKAVWQTFSLNPNLILRGGMKFYKCKECGKIFRYNSKLLRHQRSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGQGPYECKECGKGLSSNTALTQHQRIHTGEKPYACKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKGFGCRSLFIVHQRIHTGEKPYQCKECGKAFSQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKVHPVEKKPSKALGQPLLRPQGPSASLAPGCLPGPGSAPAVAVALPHAVLIPVSGPVFMLLPTSGVLSSPVQVVRVFQGLPPAVKSSPVILTPSPHPCDLSLGTSLTVTADL", "length": 473, "header": "tr|A0AAA9T8K1-1|A0AAA9T8K1_BOVIN Isoform 1 of Zinc finger protein 621 OS=Bos taurus OX=9913 GN=LOC132343483 PE=3 SV=1 CANONICAL=A0AAA9T8K1-1" }, "locus": { "chromosome": "22", "start_pos": 13371261, "end_pos": 13360172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106596.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106596.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092198.1" } ] } }, { "isoform_ac": "A0AAA9TEL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1/entry#A0AAA9TEL4-1", "sequence": { "sequence": "MKEVKIGWRTTGERAKAELSREYSKCISPEEPVTFEDVAVYFTQNQWASLDSAQRALYREVMLENYANVASLVSPFPRPDLISQLERGEAPWDPDPWEAEDLRGICPGGERGIKTEEPAVAQQASEGTEAHSRPVGGLLTNVSQHLDFESKAVWQTFSLNPNLILRGGMKFYKCKECGKIFRYNSKLLRHQRSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGQGPYECKECGKGLSSNTALTQHQRIHTGEKPYACKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKGFGCRSLFIVHQRIHTGEKPYQCKECGKAFSQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSFVQHQKVHPVEKKPSKALGQPLLRPQGPSASLAPGCLPGPGSAPAVAVALPHAVLIPVSGPVFMLLPTSGVLSSPVQVVRVFQGLPPAVKSSPVILTPSPHPCDLSLGTSLTVTADL", "length": 471, "header": "tr|A0AAA9TEL4-1|A0AAA9TEL4_BOVIN Computationally mapped isoform of Zinc finger protein 621 OS=Bos taurus OX=9913 GN=LOC132343483 PE=3 SV=1 CANONICAL=A0AAA9T8K1-1" }, "locus": { "chromosome": "22", "start_pos": 13371261, "end_pos": 13361818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115665.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115665.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096553.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096553.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132343483", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132343483", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" }, { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8K1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 201, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T8K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8K1" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 106, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7U3-1", "uniprot_ac": "A0AAA9T7U3", "uniprot_id": "A0AAA9T7U3_BOVIN", "mass": { "chemical_mass": 49455.0, "monoisotopic_mass": 49455.0 }, "refseq": {}, "gene_names": [ { "name": "TMPRSS5", "type": "recommended", "evidence": [ { "id": "A0AAA9T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ] } ], "protein_names": [ { "name": "Transmembrane protease serine 5", "type": "recommended", "evidence": [ { "id": "A0AAA9T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3/entry#names_and_taxonomy" } ] }, { "name": "Spinesin", "type": "synonym", "evidence": [ { "id": "A0AAA9T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in hearing.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S2W5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2W5#function" }, { "database": "UniProtKB", "id": "ARBA00056576", "url": "https://www.uniprot.org/uniprotkb/ARBA00056576#function" }, { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMPRSS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3", "locus": { "chromosome": "15", "start_pos": 24246030, "end_pos": 24258672, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063291", "url": "https://www.ensembl.org/id/ENSBTAG00000063291" } ] } } ], "crossref": [ { "id": "A0AAA9T7U3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7U3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15494", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15494", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S2W5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2W5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2W5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2W5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6W4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6W4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPMLDGQAPTEAQDAEEGPGSETCYGPETQQQPMSGAGRWCAGRRCWAVLGALGLLAGVGVGSWLLVLYLWPAASQPTPETLQDEMTLNCSEASSEEALLPSIPRTVSFRINTSEDFLLEVQLRARQDWLLVCHEGWSSALGARVCRSLGHLRLTHHKAVNLSDVRLNSSREFAQLSPRLEGFPEEVWQPRDRCASGQIVSLKCSECGARPLASRIVGGQAAAPGRWPWQASVTLGSRHTCGASVLGPRWVVTAAHCTHSFRLSRLSSWRVHAGLVSHSTVRPHQGAVVQRIITHPLYSAQNHDYDVALLQLRTPLHFSDTVGAVCLPAEERDFPRGSECWVSGWGHTDPGHTRSSDVLQDSVVPLLSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCLDEGTWRLVGVVSWGHGCAEPSHPGVYAKVAEFLDWIQDTAAQDSLP", "length": 457, "header": "tr|A0AAA9T7U3-1|A0AAA9T7U3_BOVIN Isoform 1 of Transmembrane protease serine 5 OS=Bos taurus OX=9913 GN=TMPRSS5 PE=4 SV=1 CANONICAL=A0AAA9T7U3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2W5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3/entry#A0AAA9S2W5-1", "sequence": { "sequence": "MSPMLDGQAPTEAQDAEEGPGSETCYGPETQQQPMSGAGRWCAGRRCWAVLGALGLLAGVGVGSWLLVLYLWPAASQPTPETLQDEMTLNCSEASSEEALLPSIPRTVSFRINTSEDFLLEVQLRARQDWLLVCHEGWSSALGARVCRSLGHLRLTHHKAVNLSDVRLNSSREFAQLSPRLEGFPEEVWQPSFRLSRLSSWRVHAGLVSHSTVRPHQGAVVQRIITHPLYSAQNHDYDVALLQLRTPLHFSDTVGAVCLPAEERDFPRGSECWVSGWGHTDPGHTRSSDVLQDSVVPLLSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCLDEGTWRLVGVVSWGHGCAEPSHPGVYAKVAEFLDWIQDTAAQDSLP", "length": 388, "header": "tr|A0AAA9S2W5-1|A0AAA9T7U3_BOVIN Computationally mapped isoform of Transmembrane protease serine 5 OS=Bos taurus OX=9913 GN=TMPRSS5 PE=4 SV=1 CANONICAL=A0AAA9T7U3-1" }, "locus": { "chromosome": "15", "start_pos": 24258672, "end_pos": 24246030, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079417.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079417.1" } ] } }, { "isoform_ac": "A0AAA9S6W4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3/entry#A0AAA9S6W4-1", "sequence": { "sequence": "THSFRLSRLSSWRVHAGLVSHSTVRPHQGAVVQRIITHPLYSAQNHDYDVALLQLRTPLHFSDTVGAVCLPAEERDFPRGSECWVSGWGHTDPGHTRSSDVLQDSVVPLLSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQDSLP", "length": 147, "header": "tr|A0AAA9S6W4-1|A0AAA9T7U3_BOVIN Computationally mapped isoform of Transmembrane protease serine 5 OS=Bos taurus OX=9913 GN=TMPRSS5 PE=4 SV=1 CANONICAL=A0AAA9T7U3-1" }, "locus": { "chromosome": "15", "start_pos": 24251029, "end_pos": 24246030, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120672.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120672.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079650.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079650.1" } ] } }, { "isoform_ac": "A0AAA9T7U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3/entry#A0AAA9T7U3-1", "sequence": { "sequence": "MSPMLDGQAPTEAQDAEEGPGSETCYGPETQQQPMSGAGRWCAGRRCWAVLGALGLLAGVGVGSWLLVLYLWPAASQPTPETLQDEMTLNCSEASSEEALLPSIPRTVSFRINTSEDFLLEVQLRARQDWLLVCHEGWSSALGARVCRSLGHLRLTHHKAVNLSDVRLNSSREFAQLSPRLEGFPEEVWQPRDRCASGQIVSLKCSECGARPLASRIVGGQAAAPGRWPWQASVTLGSRHTCGASVLGPRWVVTAAHCTHSFRLSRLSSWRVHAGLVSHSTVRPHQGAVVQRIITHPLYSAQNHDYDVALLQLRTPLHFSDTVGAVCLPAEERDFPRGSECWVSGWGHTDPGHTRSSDVLQDSVVPLLSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCLDEGTWRLVGVVSWGHGCAEPSHPGVYAKVAEFLDWIQDTAAQDSLP", "length": 457, "header": "tr|A0AAA9T7U3-1|A0AAA9T7U3_BOVIN Isoform 1 of Transmembrane protease serine 5 OS=Bos taurus OX=9913 GN=TMPRSS5 PE=4 SV=1 CANONICAL=A0AAA9T7U3-1" }, "locus": { "chromosome": "15", "start_pos": 24258672, "end_pos": 24246030, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125137.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125137.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092852.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 79, "start_aa": "Thr", "end_pos": 79, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr79", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 217, "end_pos": 452, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U3" }, { "id": "PS50287", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50287" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SRCR", "eco_id": "ECO_0000259", "start_pos": 105, "end_pos": 206, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 79 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 162, "end_pos": 164 }, { "start_pos": 169, "end_pos": 171 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8F2-1", "uniprot_ac": "A0AAA9T8F2", "uniprot_id": "A0AAA9T8F2_BOVIN", "mass": { "chemical_mass": 88219.0, "monoisotopic_mass": 88219.0 }, "refseq": { "ac": "XP_024846337", "name": "muskelin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846337" }, "gene_names": [ { "name": "MKLN1", "type": "recommended", "evidence": [ { "id": "A0AAA9T8F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ] }, { "name": "MKLN1", "type": "synonym", "evidence": [ { "id": "XP_024846337", "database": 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Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. 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"Protein Classification" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15526", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15526", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15526:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15526:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24981", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24981", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846337", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846337", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGF7-1", 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P217", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P217", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P217-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P217-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPDVGTVCWLNFKLPDSFLDTLPIYLALALLRWNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 765, "header": "tr|A0AAA9T8F2-1|A0AAA9T8F2_BOVIN Isoform 1 of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9S3L6-1", "sequence": { "sequence": "MDRNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 705, "header": "tr|A0AAA9S3L6-1|A0AAA9T8F2_BOVIN Computationally mapped isoform of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 94876812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095260.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095260.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076692.1" } ] } }, { "isoform_ac": "A0AAA9SCB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9SCB1-1", "sequence": { "sequence": "MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEAFRTWITPMLKELSSLTP", "length": 695, "header": "tr|A0AAA9SCB1-1|A0AAA9T8F2_BOVIN Computationally mapped isoform of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232256, "end_pos": 95025996, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115160.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115160.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079874.1" } ] } }, { "isoform_ac": "A0AAA9SGF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9SGF7-1", "sequence": { "sequence": "MGIGIRNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 708, "header": "tr|A0AAA9SGF7-1|A0AAA9T8F2_BOVIN Computationally mapped isoform of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 94873276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132657.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132657.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081578.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081578.1" } ] } }, { "isoform_ac": "A0AAA9T0W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9T0W2-1", "sequence": { "sequence": "MSLNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 705, "header": "tr|A0AAA9T0W2-1|A0AAA9T8F2_BOVIN Computationally mapped isoform of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 95053244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107573.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107573.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090191.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090191.1" } ] } }, { "isoform_ac": "A0AAA9T8F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9T8F2-1", "sequence": { "sequence": "MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPDVGTVCWLNFKLPDSFLDTLPIYLALALLRWNILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 765, "header": "tr|A0AAA9T8F2-1|A0AAA9T8F2_BOVIN Isoform 1 of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 95025996, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104262.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104262.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092136.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092136.1" } ] } }, { "isoform_ac": "A0AAA9TNX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAA9TNX9-1", "sequence": { "sequence": "MAAGGAVAAAPECRLLPYALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALEREDRYKTLFGRGSHLCSKNSAL", "length": 718, "header": "tr|A0AAA9TNX9-1|A0AAA9TNX9_BOVIN Computationally mapped isoform of Muskelin OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232248, "end_pos": 95025996, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090909.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090909.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100069.1" } ] } }, { "isoform_ac": "A0AAF6DM06-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0AAF6DM06-1", "sequence": { "sequence": "MNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 643, "header": "tr|A0AAF6DM06-1|A0AAF6DM06_BOVIN Computationally mapped isoform of Muskelin 1 OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=2 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 95102825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013788.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013788.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013788.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013788.7" } ] } }, { "isoform_ac": "A0ABI0P217-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2/entry#A0ABI0P217-1", "sequence": { "sequence": "MSMYLILKLERPAIVQNITFGKYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNDYNKETFTLKHKIDEQMFPCRFIKIVPLLSWGPSFNFSIWYVELSGIDDPDVVQPCLNWYSKYREQEAIRLCLKHFRQHNYTEAFESLQKKTKIALEHPMLTDLHDKLVLKGDFDACEELIEKAVNDGLFNQYISQQEYKPRWSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCISRDTEKENGPSARSCHKMCIDIQRRQIYTLGRYLDSSVRNSKSLKSDFYRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSEKHMIYTFGGRILTCNGSVDDSRASEPQFSGLFAFNCQCQTWKLLREDSCNAGPEDIQSRIGHCMLFHSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIISDGTKKDSGMVPMTGFTQRATIDPELNEIHVLSGLSKDKEKREENVRNSFWIYDIVRNSWSCVYKNDQAAKDNPSKSLQEEEPCPRFAHQLVYDELHKVHYLFGGNPGKSCSPKMRLDDFWSLKLCRPSKDYLLRHCKYLIRKHRFEEKAQMDPLSALKYLQNDLYITVDHSDPEETKEFQLLASALFKSGSDFTALGFSDVDHTYAQRTQLFDTLVNFFPDSMTPPKGNLVDLITL", "length": 682, "header": "tr|A0ABI0P217-1|A0ABI0P217_BOVIN Computationally mapped isoform of Muskelin 1 OS=Bos taurus OX=9913 GN=MKLN1 PE=4 SV=1 CANONICAL=A0AAA9T8F2-1" }, "locus": { "chromosome": "4", "start_pos": 95232321, "end_pos": 95102262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142036.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142036.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104402.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104402.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "postsynaptic endosome membrane", "id": "GO:0098895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098895", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "postsynaptic specialization membrane of symmetric synapse", "id": "GO:0099164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099164", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" }, { "name": "neurotransmitter receptor transport postsynaptic membrane to endosome", "id": "GO:0098968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098968", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8F2" }, { "id": "PS50897", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50897" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTLH", "eco_id": "ECO_0000259", "start_pos": 236, "end_pos": 288, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 127, "end_pos": 129 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 442, "end_pos": 444 } ] }, "class_list": [], "section_stats": [ { 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7E5-1", "uniprot_ac": "A0AAA9T7E5", "uniprot_id": "A0AAA9T7E5_BOVIN", "mass": { "chemical_mass": 69069.0, "monoisotopic_mass": 69069.0 }, "refseq": { "ac": "XP_024833726", "name": "hyaluronan synthase 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833726" }, "gene_names": [ { "name": "HAS3", "type": "recommended", "evidence": [ { "id": "A0AAA9T7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ] }, { "name": "HAS3", "type": "synonym", "evidence": [ { "id": "XP_024833726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833726" } ] } ], "protein_names": [ { "name": "hyaluronan synthase", "type": "recommended", "evidence": [ { "id": "A0AAA9T7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.212", "type": "synonym", "evidence": [ { "id": "A0AAA9T7E5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#names_and_taxonomy" } ] }, { "name": "hyaluronan synthase 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024833726", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833726" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HAS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5", "locus": { "chromosome": "18", "start_pos": 36332895, "end_pos": 36306248, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050602", "url": "https://www.ensembl.org/id/ENSBTAG00000050602" } ] } } ], "crossref": [ { "id": "A0AAA9T7E5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7E5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06434", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06434", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "286824", "url": "https://www.ncbi.nlm.nih.gov/gene/286824", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22913:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22913:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13641", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13641", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833726", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833726", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3P8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0D9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTASDKPSLSSTPWPAGTAPLISRGWDCGKRPARGRKLWLQPNPGTLPKCQLLHQMPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRTLKLPSPLRRSVALCIAAYQEDPDYLRKCLRSAQRIAFPDLKVVLVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV", "length": 608, "header": "tr|A0AAA9T7E5-1|A0AAA9T7E5_BOVIN Isoform 1 of hyaluronan synthase OS=Bos taurus OX=9913 GN=HAS3 PE=4 SV=1 CANONICAL=A0AAA9T7E5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3P8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#A0AAA9S3P8-1", "sequence": { "sequence": "MPPLSAGTLCQGSARPPSPQEMPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRTLKLPSPLRRSVALCIAAYQEDPDYLRKCLRSAQRIAFPDLKVVLVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV", "length": 574, "header": "tr|A0AAA9S3P8-1|A0AAA9T7E5_BOVIN Computationally mapped isoform of hyaluronan synthase OS=Bos taurus OX=9913 GN=HAS3 PE=4 SV=1 CANONICAL=A0AAA9T7E5-1" }, "locus": { "chromosome": "18", "start_pos": 36329625, "end_pos": 36322089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076727.1" } ] } }, { "isoform_ac": "A0AAA9SGE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#A0AAA9SGE4-1", "sequence": { "sequence": "MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRTLKLPSPLRRSVALCIAAYQEDPDYLRKCLRSAQRIAFPDLKVVLVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQSPGEEGMAVEDDQVSVAEAWSFHQCNISREQ", "length": 277, "header": "tr|A0AAA9SGE4-1|A0AAA9T7E5_BOVIN Computationally mapped isoform of hyaluronan synthase OS=Bos taurus OX=9913 GN=HAS3 PE=4 SV=1 CANONICAL=A0AAA9T7E5-1" }, "locus": { "chromosome": "18", "start_pos": 36332892, "end_pos": 36324293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081562.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081562.1" } ] } }, { "isoform_ac": "A0AAA9T7E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#A0AAA9T7E5-1", "sequence": { "sequence": "MTASDKPSLSSTPWPAGTAPLISRGWDCGKRPARGRKLWLQPNPGTLPKCQLLHQMPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRTLKLPSPLRRSVALCIAAYQEDPDYLRKCLRSAQRIAFPDLKVVLVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV", "length": 608, "header": "tr|A0AAA9T7E5-1|A0AAA9T7E5_BOVIN Isoform 1 of hyaluronan synthase OS=Bos taurus OX=9913 GN=HAS3 PE=4 SV=1 CANONICAL=A0AAA9T7E5-1" }, "locus": { "chromosome": "18", "start_pos": 36329625, "end_pos": 36306278, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097212.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097212.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094674.1" } ] } }, { "isoform_ac": "A0AAA9U0D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5/entry#A0AAA9U0D9-1", "sequence": { "sequence": "MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRTLKLPSPLRRSVALCIAAYQEDPDYLRKCLRSAQRIAFPDLKVVLVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEVASGQDSTSSPEIQRELRSVLKQIVSSIQWQLLMGE", "length": 588, "header": "tr|A0AAA9U0D9-1|A0AAA9U0D9_BOVIN Computationally mapped isoform of hyaluronan synthase OS=Bos taurus OX=9913 GN=HAS3 PE=4 SV=1 CANONICAL=A0AAA9T7E5-1" }, "locus": { "chromosome": "18", "start_pos": 36329979, "end_pos": 36324293, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118397.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118397.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103066.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "hyaluranon cable", "id": "GO:0036117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "glycosaminoglycan biosynthetic process", "id": "GO:0006024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "polysaccharide biosynthetic process", "id": "GO:0000271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "extracellular matrix assembly", "id": "GO:0085029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085029", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E5" } ], "pmid": "" }, { "name": "positive regulation of hyaluranon cable assembly", "id": 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"id": "100140143", "url": "https://www.ncbi.nlm.nih.gov/gene/100140143", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR052881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140143", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140143", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48138", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48138", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48138:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48138:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002686106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T967", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T967", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T967-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T967-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCDQQQIQCYQPHPQYCVTCSPCYISQTPCANSQVVVQAPCEMQIVECPAPCPVQVSQVKCQAPCQSKTTEVKGQAPRESKTIQVKGKAPCESKTTQVKGKASCESKTTQVKGQAPSQPQFTCVQCQVPCQSEVSYVQCEGPCPVQTCYVECAPVCYTETCYVECPGQSYVPCPAPQPVQTYVTGPLVCQPQGRFSTQCQYQGSYSGCDPQLQSRASFSTWAPQCQTRGSYGSFPAQSRSRSTSRCLPPRQLQPSYRSCSPPRRSEPYYSSSCLPSRCSLGSYNYCTPPRRSEPIYNSDCSRRPTLGCSQRCGPKCRIEISSPRCPRQVPPQKCPVQIPPIRRCSESCAPRPSWGTSCPDLRSRAEPCPLPSFHPPRRLDQCPEPSLRRSPPPAPCPRPLPAPRTCSRPERCVSPEFRPCSPPRRLSEPCLYPEPRPVPYPAPRHPRPVQCDLSAPRPYPQPYERQESFPLLEPIPLPEPIPLPSPCPSPEPCVEPRPNPCTGDLGCHESSPHRLDTEAPICGPAGYNWWQDSEPGCRPCDVGLPESQGLGGCGDQGGVSVGMKGGTRGGVKGAYF", "length": 576, "header": "tr|A0AAA9T967-1|A0AAA9T967_BOVIN Isoform 1 of Keratinocyte proline rich protein OS=Bos taurus OX=9913 GN=KPRP PE=4 SV=1 CANONICAL=A0AAA9T967-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T967/entry#A0AAA9S5P4-1", "sequence": { "sequence": "MCDQQQIQCYQPHPQYCVTCSPCYISQTPCANSQVVVQAPCEMQIVECPAPCPVQVSQVKCQAPCQSKTTEVKGQAPRESKTIQVKGKASCESKTTQVKGQAPSQPQFTCVQCQVPCQSEVSYVQCEGPCPVQTCYVECAPVCYTETCYVECPGQSYVPCPAPQPVQTYVTGPLVCQPQGRFSTQCQYQGSYSGCDPQLQSRASFSTWAPQCQTRGSYGSFPAQSRSRSTSRCLPPRQLQPSYRSCSPPRRSEPYYSSSCLPSRCSLGSYNYCTPPRRSEPIYNSDCSRRPTLGCSQRCGPKCRIEISSPRCPRQVPPQKCPVQIPPIRRCSESCAPRPSWGTSCPDLRSRAEPCPLPSFHPPRRLDQCPEPSLRRSPPPAPCPRPLPAPRTCSRPERCVSPEFRPCSPPRRLSEPCLYPEPRPVPYPAPRHPRPVQCDLSAPRPYPQPYERQESFPLLEPIPLPEPIPLPSPCPSPEPCVEPRPNPCTGDLGCHESSPHRLDTEAPICGPAGYNWWQDSEPGCRPCDVGLPESQGLGGCGDQGGVSVGMKGGTRGGVKGAYF", "length": 563, "header": "tr|A0AAA9S5P4-1|A0AAA9T967_BOVIN Computationally mapped isoform of Keratinocyte proline rich protein OS=Bos taurus OX=9913 GN=KPRP PE=4 SV=1 CANONICAL=A0AAA9T967-1" }, "locus": { "chromosome": "3", "start_pos": 18025249, "end_pos": 18023522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045306.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045306.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078603.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078603.1" } ] } }, { "isoform_ac": "A0AAA9T967-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T967/entry#A0AAA9T967-1", "sequence": { "sequence": "MCDQQQIQCYQPHPQYCVTCSPCYISQTPCANSQVVVQAPCEMQIVECPAPCPVQVSQVKCQAPCQSKTTEVKGQAPRESKTIQVKGKAPCESKTTQVKGKASCESKTTQVKGQAPSQPQFTCVQCQVPCQSEVSYVQCEGPCPVQTCYVECAPVCYTETCYVECPGQSYVPCPAPQPVQTYVTGPLVCQPQGRFSTQCQYQGSYSGCDPQLQSRASFSTWAPQCQTRGSYGSFPAQSRSRSTSRCLPPRQLQPSYRSCSPPRRSEPYYSSSCLPSRCSLGSYNYCTPPRRSEPIYNSDCSRRPTLGCSQRCGPKCRIEISSPRCPRQVPPQKCPVQIPPIRRCSESCAPRPSWGTSCPDLRSRAEPCPLPSFHPPRRLDQCPEPSLRRSPPPAPCPRPLPAPRTCSRPERCVSPEFRPCSPPRRLSEPCLYPEPRPVPYPAPRHPRPVQCDLSAPRPYPQPYERQESFPLLEPIPLPEPIPLPSPCPSPEPCVEPRPNPCTGDLGCHESSPHRLDTEAPICGPAGYNWWQDSEPGCRPCDVGLPESQGLGGCGDQGGVSVGMKGGTRGGVKGAYF", "length": 576, "header": "tr|A0AAA9T967-1|A0AAA9T967_BOVIN Isoform 1 of Keratinocyte proline rich protein OS=Bos taurus OX=9913 GN=KPRP PE=4 SV=1 CANONICAL=A0AAA9T967-1" }, "locus": { "chromosome": "3", "start_pos": 18025249, "end_pos": 18023522, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103687.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103687.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092443.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140143", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140143", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T698-1", "uniprot_ac": "A0AAA9T698", "uniprot_id": "A0AAA9T698_BOVIN", "mass": { "chemical_mass": 22995.0, "monoisotopic_mass": 22995.0 }, "refseq": {}, "gene_names": [ { "name": "PPP1R2", "type": "recommended", "evidence": [ { "id": "A0AAA9T698", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory inhibitor subunit 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T698", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Inhibitor of protein-phosphatase 1.", "evidence": [ { "database": "UniProtKB", "id": "F1MTZ0", "url": "https://www.uniprot.org/uniprotkb/F1MTZ0#function" }, { "database": "UniProtKB", "id": "ARBA00002900", "url": "https://www.uniprot.org/uniprotkb/ARBA00002900#function" }, { "database": "UniProtKB", "id": "A0AAA9S627", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S627#function" }, { "database": "UniProtKB", "id": "A0AAA9T698", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698#function" }, { "database": "UniProtKB", "id": "A0AAA9SL86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL86#function" }, { "database": "UniProtKB", "id": "A0AAA9TGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T698", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698", "locus": { "chromosome": "1", "start_pos": 72138818, "end_pos": 72100127, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006724", "url": "https://www.ensembl.org/id/ENSBTAG00000006724" } ] } } ], "crossref": [ { "id": "A0AAA9T698", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T698", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006724", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006724", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RAHYNEG", "url": "https://omabrowser.org/oma/group/RAHYNEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MTZ0", "url": "https://www.orthodb.org/?gene=F1MTZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12398:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12398:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S627", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S627", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S627-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S627-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T698", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T698-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTZ0", "url": "https://www.uniprot.org/uniprotkb/F1MTZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MTZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASTASHRPIKGILKNKSSTTSSVVSSAEQPGKSVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMVADDEDALSDSETTEALTPDILARKLTAAAAESLEPKYRVREQESSGDEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLNDEEEDEEMSETAAGESMNMEESSQGSATSDQLQNKSQSS", "length": 207, "header": "tr|A0AAA9T698-1|A0AAA9T698_BOVIN Isoform 1 of Protein phosphatase 1 regulatory inhibitor subunit 2 OS=Bos taurus OX=9913 GN=PPP1R2 PE=1 SV=1 CANONICAL=A0AAA9T698-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S627-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698/entry#A0AAA9S627-1", "sequence": { "sequence": "MAASTASHRPIKGILKNKSSTTSSVVSSAEQPGKSVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMVADDEDALSDSETTEALTPDILARKLTAAAAESLEPKYRVREQESSGDEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLNDEEEDEEMSETAAGESMNMEESSQGFPCGSAGKESACNVGDLVLIPGLGRSTGEGKGYPFQYSGLENSMDCIVCGIAKSRT", "length": 249, "header": "tr|A0AAA9S627-1|A0AAA9T698_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory inhibitor subunit 2 OS=Bos taurus OX=9913 GN=PPP1R2 PE=1 SV=1 CANONICAL=A0AAA9T698-1" }, "locus": { "chromosome": "1", "start_pos": 72137911, "end_pos": 72100419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101017.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101017.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079298.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079298.1" } ] } }, { "isoform_ac": "A0AAA9SL86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T698/entry#A0AAA9SL86-1", "sequence": { "sequence": "MAASTASHRPIKGILKNKSSTTSSVVSSAEQPGKSVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMVADDEDALSDSETTEALTPDILARKLTAAAAESLEPKYRVREQESSGDEDSDLSPEERGFPCGSAGKESACNVGDLVLIPGLGRSTGEGKGYPFQYSGLENSMDCIVCGIAKSRT", "length": 193, "header": "tr|A0AAA9SL86-1|A0AAA9T698_BOVIN Computationally mapped isoform of Protein phosphatase 1 regulatory inhibitor subunit 2 OS=Bos taurus OX=9913 GN=PPP1R2 PE=1 SV=1 CANONICAL=A0AAA9T698-1" }, "locus": { "chromosome": "1", "start_pos": 72137911, "end_pos": 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"https://www.uniprot.org/uniprotkb/A0AAA9T728-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQL2", "url": "https://www.uniprot.org/uniprotkb/F1MQL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MQL2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3N0", "url": "https://www.uniprot.org/uniprotkb/G3N3N0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3N0-1", "url": "https://www.uniprot.org/uniprotkb/G3N3N0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNAALCPACHADKSVRAQGHLQELDRTPDYYGCNGEDTKELGPRSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEAFKQFGDHFIDGEVLSDSGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRTSPCLDRDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKELTEELGELEASSDEEAMVTTRVVRRRLIIQGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEVTLSEPSILSSTSQFQAEPVEGRRVSKVVKTTVVHGERMEKHLGDSSLATDLPSAKDDFEEALSYTGSHMKVYSPSLVENEVLKEDGSIIRRTTMSKARTQKRAVVKDQQGKRIYLEHLEDVPEALDQDDLQHDLQQLLRHFCKEDSKQEAQ", "length": 4179, "header": "tr|A0AAA9T728-1|A0AAA9T728_BOVIN Isoform 1 of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9S8Q0-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEDDNE", "length": 3891, "header": "tr|A0AAA9S8Q0-1|A0AAA9T728_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110723.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110723.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081650.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081650.1" } ] } }, { "isoform_ac": "A0AAA9SAE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9SAE9-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEVTLSEPSILSSTSQFQAEPVEGRRVSKVVKTTVVHGERMEKHLGDSSLATDLPSAKDDFEEDDNE", "length": 3960, "header": "tr|A0AAA9SAE9-1|A0AAA9T728_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083066.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083066.1" } ] } }, { "isoform_ac": "A0AAA9SBC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9SBC2-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRTSPCLDRDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEDDNE", "length": 3878, "header": "tr|A0AAA9SBC2-1|A0AAA9T728_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131076.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131076.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081192.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081192.1" } ] } }, { "isoform_ac": "A0AAA9T015-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9T015-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEDDNE", "length": 3932, "header": "tr|A0AAA9T015-1|A0AAA9T728_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089872.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089872.1" } ] } }, { "isoform_ac": "A0AAA9T728-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9T728-1", "sequence": { "sequence": "MGNAALCPACHADKSVRAQGHLQELDRTPDYYGCNGEDTKELGPRSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEAFKQFGDHFIDGEVLSDSGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRTSPCLDRDNSSFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKELTEELGELEASSDEEAMVTTRVVRRRLIIQGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEVTLSEPSILSSTSQFQAEPVEGRRVSKVVKTTVVHGERMEKHLGDSSLATDLPSAKDDFEEALSYTGSHMKVYSPSLVENEVLKEDGSIIRRTTMSKARTQKRAVVKDQQGKRIYLEHLEDVPEALDQDDLQHDLQQLLRHFCKEDSKQEAQ", "length": 4179, "header": "tr|A0AAA9T728-1|A0AAA9T728_BOVIN Isoform 1 of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12470152, "end_pos": 12218924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094261.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094261.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094570.1" } ] } }, { "isoform_ac": "A0AAA9TWC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9TWC6-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKELTEELGELEASSDEEAMVTTRVVRRRLIIQGDDMPDIPPETVTEEEYIDEHGHTVVKKDDNE", "length": 3875, "header": "tr|A0AAA9TWC6-1|A0AAA9TWC6_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096066.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096066.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100922.1" } ] } }, { "isoform_ac": "A0AAA9TZY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#A0AAA9TZY0-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKELTEELGELEASSDEEAMVTTRVVRRRLIIQGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEVTLSEPSILSSTSQFQAEPVEGRRVSKVVKTTVVHGERMEKHLGDSSLATDLPSAKDDFEEDDNE", "length": 3991, "header": "tr|A0AAA9TZY0-1|A0AAA9TZY0_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=1 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102325.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102325.1" } ] } }, { "isoform_ac": "F1MQL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#F1MQL2-1", "sequence": { "sequence": "MMNEDAAQKSDSGEKFNGSSQRRKKPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKGDDMPDIPPETVTEEEYIDEHGHTVVKKVTRKIIRRFISSDGTEKEEITMQGAPQDSISVDEGDGYSKVIKRIVLKSDTEQSEDDNE", "length": 3953, "header": "tr|F1MQL2-1|F1MQL2_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=4 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12581528, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003097.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003097.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003097.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003097.7" } ] } }, { "isoform_ac": "G3N3N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728/entry#G3N3N0-1", "sequence": { "sequence": "MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSAVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAMAKNGYTPLHIAAKKNQMQIASTLLSYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDAVVIPSHQVTTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHYCEYTEEELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDGSDRAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTGDEGSVPRSQPERELVEEEWVIVSEEEIEEAKQKASLEIAEYPCVEVRLDKETKVEVEKDSTGLVNYLTEDLNSYVPPHEEQPQKEQGMVGEKPEAQGPSRRSESEGKDAPSEETQSTQKQPKPSLGIKKPVRRKLKEKQKQKEDSPQASAEKTELKKGSSEESLDEDTSSAPEPLPAVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKKVTQRTHLTASPSLKSERHAPASASSRTERHTSLSSSAKTERHPPVSPSSKNEKHSPVSPSAKAEKQSPVSSSSKTEKHSPVSPSTKTERHSPMSSSTKTERHPPVSPSGKTDKRPPGSPSGRSEKHPPVSPGRTEKRLPVSPAGRMEKHSPVSSSGKTEKHLPVSPSGKTDKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKPKQPQEKGRGRLEKEKGPIVTPREAQKMESQTIKRGQRFLVTGFSEPRRAVRASSTGFKREDGAGEKEKSLNHKTPEPVQPVPEEESHKDSEVPKEKLADDQGDMDLQISPDRKTSTDFSDVIKQELEDNDKYQQFRMTEEPEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALHGSSESLKPEGVADSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGETHETTKLETAPESHSEKGHPSTKDVADGSEGQGAAVTEAVESSAEHQLTEATPDPSKDICPPQEGDSLGGQSVSLAKETSEGLTEEVTCDEGPRAHISPSHETQTDTEAQESTATKPSGEAEASPLSEAAVKAGSGTESKPQAAIRSPQGLELALPSRESEVFSPGADESFAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPSAVAKTELFTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDTPKPAVIPECAEEDDSENGEKKRFTPEEEMFKMVTKVKTFDELEQEAKQKRDYKREPKQEESSSSSDADVDCSADTDEPKHTESVEDESDAPVVVTTEGREASSSSESEPELTQLKKGADSGLLAEPVIRVQPPSPLPSSIDSNSSPEEIQFQPIVSKQYTFKMNEDAQEDSDKSEEEKDYKSRLPEDSHALPTDGPDMSYDDLNGDTYQSKLCDGLEYEIGSPSDSAAPVSSGLRSSPGDDVSEQLVIHKESLALQDTGENDLEELDVPEVESSQADPPSEGSPSFSSLPLCPASEAKELDEDMVSTASATEMEVTKPDQAFESLPEDCSIQDSLITTQTDRSSLDVPVSDPTETEEIYDPQIISPYENVPSQSFFSGEESKTQTDTRHTSFHSSEEYSVTITSSVEDVVETSSSDKTVSSKEANFEEQVLEVESKQESTLQEIQSHGASSSLEPPVPKTSTVVSEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREEAVSQDMKEGGTGAEAPQVETSAESLTLSESKETVDDEAELLPDDLSEEVEEIHTSDTPLSSQIDISASTETSMKEATSTGLEDLPTRQMGDSLPPSSEKQTTCPDFPEQVVQVQLDFSTVTRSVYSDRGDDSPDSSPEEQKSVIEIPTATMENVPSTESKSKIPVRTIPTSTSIPPSVEYESSLSEDFLPSLDEESKEDEAKPKSKIPVKAPAQRVEQQPSHLDSPLKKTGRPQGQDLTSSAPDDRSKSESDASLDVKTKCPVETRSYTEAEIESTGEEEELELESEEGATRPKIFASRLPVKSKSTASSCRGPTSPTKDNKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQDLVSDDESSSALEVSVIENLPPVETENSIPEDLFDTRPIWDESIETLIERIPDENGHDHAEDQQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGRHATDTSLVECLTKINRMDIVHLMETSTEALQERIGHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEHAASKEDEASDHPPIVSEEDISVGYSTLQDGIPKTEGDGSATELLPQTQKEQVQQDFSGKMQDLPEESALEQQEYFVTTPGTEMSETQKATGTSGSPTKTPEEIVTPSEEERLYLQTPTSSERGGSPVVQEPEEPPERREESSPRKTSLVIVESAEDQPQAFERLDEEAAFQKDDNE", "length": 3816, "header": "tr|G3N3N0-1|G3N3N0_BOVIN Computationally mapped isoform of Ankyrin 2 OS=Bos taurus OX=9913 GN=ANK2 PE=4 SV=3 CANONICAL=A0AAA9T728-1" }, "locus": { "chromosome": "6", "start_pos": 12727666, "end_pos": 12219093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063062.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063062.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056535.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056535.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3501, "start_aa": "Thr", "end_pos": 3501, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3501", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "T-tubule", "id": "GO:0030315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "regulation of heart rate by cardiac conduction", "id": "GO:0086091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "regulation of ventricular cardiac muscle cell membrane repolarization", "id": "GO:0060307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "atrial septum development", "id": "GO:0003283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "id": "GO:0010881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010881", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "protein localization to endoplasmic reticulum", "id": "GO:0070972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070972", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "ventricular cardiac muscle cell action potential", "id": "GO:0086005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "atrial cardiac muscle cell action potential", "id": "GO:0086014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086014", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "SA node cell to atrial cardiac muscle cell communication", "id": "GO:0086070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "regulation of SA node cell action potential", "id": "GO:0098907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098907", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "regulation of atrial cardiac muscle cell action potential", "id": "GO:0098910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098910", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "spectrin binding", "id": "GO:0030507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "phosphorylation-dependent protein binding", "id": "GO:0140031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T728", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { 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"structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" }, { "id": "PS50017", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Death", "eco_id": "ECO_0000259", "start_pos": 3613, "end_pos": 3697, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T728" }, { "id": "PS51145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZU5", "eco_id": "ECO_0000259", "start_pos": 1015, "end_pos": 1203, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 3501 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1012, "end_pos": 1014 }, { "start_pos": 1341, "end_pos": 1343 }, { "start_pos": 1496, "end_pos": 1498 }, { "start_pos": 172, "end_pos": 174 }, { "start_pos": 202, "end_pos": 204 }, { "start_pos": 2223, "end_pos": 2225 }, { "start_pos": 244, "end_pos": 246 }, { "start_pos": 2496, "end_pos": 2498 }, { "start_pos": 2750, "end_pos": 2752 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 805, "end_pos": 807 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"https://www.uniprot.org/uniprotkb/A0AAA9S8Z0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8Z0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIQ0", "url": "https://www.uniprot.org/uniprotkb/E1BIQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BIQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIACQVSWRPAGIAARVSGCGLWVMVASVCQGGIGHSPSYRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRSIRPLFPAGYFYDTQILCNLLAVDGVNEPDVLAINGASVALSLSDIPWNGPIGAVRIGMIDGECVVNPTRKEMANSTLNLVVTGAPKSQIVMLEASAENILQQDFCHAIKVGVKHTQQIIQGIQQLVKENGVTKRTPQKLFVPSPEIVKHAHKLAMEKLYTVFTDYEHDKISRDEAINKIRLDTEEQLKEKFPEVDSCEIIESFNIATKDVFRSIILNEYKRCDGRDLTSLRNINCEVDMFKILHGSSLFQRGQTQVLCTVTFDSLESNFKSDRIITAINGIKDKNFMLHYEFPPYATNEIGKVTGINRRELGHGALAERALYPVIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAGVAIGLVTKNSPDKGEIEDYRLLTDILGIEDYHGDMDFKIAGTSKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVGPGGYHLKKLQAETGVTISQVDEETFSIFAPTPSAMHEARDFITDICRDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHPSALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVKTLNDRSSIVMGESVSQSSSNSP", "length": 770, "header": "tr|A0AAA9T7E7-1|A0AAA9T7E7_BOVIN Isoform 1 of Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=PNPT1 PE=3 SV=1 CANONICAL=A0AAA9T7E7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E7/entry#A0AAA9S8Z0-1", "sequence": { "sequence": "MAACRHCCSCLRLRPLGDGRLRLPGRDRTLTQLQVRALWGGTGPRSVAVDLGSRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRSIRPLFPAGYFYDTQILCNLLAVDGVNEPDVLAINGASVALSLSDIPWNGPIGAVRIGMIDGECVVNPTRKEMANSTLNLVVTGAPKSQIVMLEASAENILQQDFCHAIKVGVKHTQQIIQGIQQLVKENGVTKRTPQKLFVPSPEIVKHAHKLAMEKLYTVFTDYEHDKISRDEAINKIRLDTEEQLKEKFPEVDSCEIIESFNIATKDVFRSIILNEYKRCDGRDLTSLRNINCEVDMFKILHGSSLFQRGQTQVLCTVTFDSLESNFKSDRIITAINGIKDKNFMLHYEFPPYATNEIGKVTGINRRELGHGALAERALYPVIPKDFPFTIRVTSEVLESNGVPISSAVAGVAIGLVTKNSPDKGEIEDYRLLTDILGIEDYHGDMDFKIAGTSKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVGPGGYHLKKLQAETGVTISQVDEETFSIFAPTPSAMHEARDFITDICRDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHPSALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVKTLNDRSSIVMGESVSQSSSNSP", "length": 765, "header": "tr|A0AAA9S8Z0-1|A0AAA9T7E7_BOVIN Computationally mapped isoform of Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=PNPT1 PE=3 SV=1 CANONICAL=A0AAA9T7E7-1" }, "locus": { "chromosome": "11", "start_pos": 38347120, "end_pos": 38307234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120285.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120285.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078623.1" } ] } }, { "isoform_ac": "A0AAA9SFV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E7/entry#A0AAA9SFV0-1", "sequence": { "sequence": "MAACRHCCSCLRLRPLGDGRLRLPGRDRTLTQLQVRALWGGTGPRSVAVDLGSRKLEISSGKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRSIRPLFPAGYFYDTQILCNLLAVDGVNEPDVLAINGGAVRIGMIDGECVVNPTRKEMANSTLNLVVTGAPKSQIVMLEASAENILQQDFCHAIKVGVKHTQQIIQGIQQLVKENGVTKRTPQKLFVPSPEIVKHAHKLAMEKLYTVFTDYEHDKISRDEAINKIRLDTEEQLKEKFPEVDSCEIIESFNIATKDVFRSIILNEYKRCDGRDLTSLRNINCEVDMFKILHGSSLFQRGQTQVLCTVTFDSLESNFKSDRIITAINGIKDKNFMLHYEFPPYATNEIGKVTGINRRELGHGALAERALYPVIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAGVAIGLVTKNSPDKGEIEDYRLLTDILGIEDYHGDMDFKIAGTSKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASRKENGPVVETVQVPLSKRAKFVGPGGYHLKKLQAETGVTISQVDEETFSIFAPTPSAMHEARDFITDICRDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHPSALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVKTLNDRSSIVMGESVSQSSSNSP", "length": 767, "header": "tr|A0AAA9SFV0-1|A0AAA9T7E7_BOVIN Computationally mapped isoform of Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Bos taurus OX=9913 GN=PNPT1 PE=3 SV=1 CANONICAL=A0AAA9T7E7-1" }, "locus": { "chromosome": "11", "start_pos": 38347120, "end_pos": 38307234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081344.1" } ] } }, { "isoform_ac": "A0AAA9T7E7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E7/entry#A0AAA9T7E7-1", "sequence": { "sequence": 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"end_pos": 38307234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011729.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011729.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011729.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011729.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 640, "start_aa": "Thr", "end_pos": 640, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr640", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], 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"count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T741-1", "uniprot_ac": "A0AAA9T741", "uniprot_id": "A0AAA9T741_BOVIN", "mass": { "chemical_mass": 315113.0, "monoisotopic_mass": 315113.0 }, "refseq": {}, "gene_names": [ { "name": "LOC616782", "type": "recommended", "evidence": [ { "id": "A0AAA9T741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741" } ] } ], "protein_names": [ { "name": "Vitellogenin domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T741", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T741", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC616782", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000013305", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013305", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR37860", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37860", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37860:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37860:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09172", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09172", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9D6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SW86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T741", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T741-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSP9", "url": "https://www.uniprot.org/uniprotkb/F1MSP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSP9-1", "url": "https://www.uniprot.org/uniprotkb/F1MSP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPDSLVGQAASCMTSCTGSADPHLPVGTRYVYHFSTNTSTSLQGAQVGGSGLGLQGLVTLDVLGPCQMALQLQHFQLTSILGSKVEVLKQSESLSAVLGREPLRLVLQAGRVVRLCPRRAEPRWALNVKRAVLSLLQSHPGVRDPHTVEEVDILGRCPTTYQQLGSRLHKTKALGQCSLRRVRASLRSQALPAAEESGLASRLTCVQSLQAGVLREASCTQLDTAGPLSREASTAPMSTFSSLSLLQEVPLDPAVTERLTSDSDSGDLTPSSLLYEWEETPSQATVAAGAASVRRLCLAQATSFEATELFLTLVSELRGLSADELMELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQKDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGTIKVTADSAVLGFLLRDKHEKAGNSTSMRSVTCILAQNSSQTLPGELRLSGRLQAQTGSLGGQASLRADTASLALVGVCTWGPGHGQLSGSLSHNISALSEAGLSSEAGILLSHTHVTSNFSVRVMLRSSGGQLDGALGLEGVATSAPGSQLRASLHHTVPGLGRWGLPFSVDGRGHLQLEGPSLEAGLVVSVDGEELGGAKERRGAGDGQELTLGLHPSLVRLQNPAVLALNSSFLVHTFGASLVAQVSSGDTFARAHIHSACGHRAHLDTGLQHAWPPLQALGVPPNNHIRVSVGGDEPPRAQLEVALGLCTLTARGGFRSEASVTHNWTLALVNHCPLLEATGIPRALRSKGSLSWGPCEFDLTTDFHSDRGDAHLQLARSCGPQTLVLGHLAHSLPLLGRLGLPPRSAISLTVQTGPAPHSSLSLQMGPCQLQGALEQHTENQSTWMLATEPGCPLLEALGGEAEASGVLAAASQTASLTLVVTLHPSEATLRAKLRPALPAPHALPPETSLTVHCGWEAGHRLRLELHTGACELQGSGELQLDRRLQWRVVAESSCEGLQALGVPGRVNSSGYIVVNSTAMDAQVLVTVDASTLRGLLVLSTTETQQEVNLLLTHNLPQPNPLALPAQILLYLTNERLGPSYRHTLWVGVDGKEVSADVDSSGAGFENSGRVSSGSTSLNYSVSCHHRDGRLEFSGWSEHNSWALRQAGFPGEARLGAELQMQKTQTQARVVLQAGDDGISMDAVALVARPVNGPLELVVNVSHTAPLLRRLGLPFASQLMFRELWGKEEMHSSLQLTCDSQTSLVLNIQGHNQALSKELRLSGQHHLPVLLGRCPSRASASAKLRYSEGGAEGTFVLMVEEHHFHMGAGLAAAKNSLTNIIKLEQNFPQFHALPGELVLQTSYERARGTQVLHHTVLWDGQGVALKGSLNGSLSMPFLKPAGTLGLQVELTHPLPLPLPWHCSFRLTSEHSARRHQDDLVVGWDGKDQVALSSSLRLGKGKLAARLALAHPFSLSWRQAEASGLAESRGGRQSWQVQLAWNG", "length": 2894, "header": "tr|A0AAA9T741-1|A0AAA9T741_BOVIN Isoform 1 of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=1 CANONICAL=A0AAA9T741-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#A0AAA9S9D6-1", "sequence": { "sequence": "MELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGTIKVTADSAVLGFLLRDKHEKAGNSTSMRSVTCILAQNSSQTLPGELRLSGRLQAQTGSLGGQASLRADTASLALVGVCTWGPGHGQLSGSLSHNISALSEAGLSSEAGILLSHTHVTSNFSVRVMLRSSGGQLDGALGLEGVATSAPGSQLRASLHHTVPGLGRWGLPFSVDGRGHLQNPAVLALNSSFLVHTFGASLVAQVSSGDTFARAHIHSACGHRAHLDTGLQHAWPPLQALGVPPNNHIRVSVGGDEPPRAQLEVALGLCTLTARGGFRSEASVTHNWTLALVNHCPLLEATGIPRALRSKGSLSWGPCEFDLTTDFHSDRGDAHLQLARSCGPQTLVLGHLAHSLPLLGRLGLPPRSAISLTVQTGPAPHSSLSLQMGPCQLQGALEQHTENQSTWMLATEPGCPLLEALGGEAEASGVLAAASQTASLTLVVTLHPSEATLRAKLRPALPAPHALPPETSLTVHCGWEAGHRLRLELHTGACELQGSGELQLDRRLQWRVVAESSCEGLQALGVPGRVNSSGYIVVNSTAMDAQVLVTVDASTLRGLLVLSTTETQQEVNLLLTHNLPQPNPLALPAQILLYLTNERLGPSYRHTLWVGVDGKEVSADVDSSGAGFENSGRVSSGSTSLNYSVSCHHRDGRLEFSGWSEHNSWALRQAGFPGEARLGAELQMQSKAAGPCPGVGVGPPTLTPARQPQARRDPEFQD", "length": 2235, "header": "tr|A0AAA9S9D6-1|A0AAA9T741_BOVIN Computationally mapped isoform of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=1 CANONICAL=A0AAA9T741-1" }, "locus": { "chromosome": "25", "start_pos": 10173545, "end_pos": 10073371, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089478.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089478.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080012.1" } ] } }, { "isoform_ac": "A0AAA9SW86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#A0AAA9SW86-1", "sequence": { "sequence": "MPDSLVGQAASCMTSCTGSADPHLPVGTRYVYHFSTNTSTSLQGAQVGGSGLGLQGLVTLDVLGPCQMALQLQHFQLTSILGSKVEVLKQSESLSAVLGREPLRLVLQAGRVVRLCPRRAEPRWALNVKRAVLSLLQSHPGVRDPHTVEEVDILGRCPTTYQQLGSRLHKTKALGQCSLRRVRASLRSQALPAAEEQSGLASRLTCVQSLQAGVLREASCTQLDTAGPLSREASTAPMSTFSSLSLLQEVPLDPAVTERLTSDSDSGDLTPSSLLYEWEETPSQATVAAGAASVRRLCLAQATSFEATELFLTLVSELRGLSADELMELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQKDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGTIKVTADSAVLGFLLRDKHEKAGNSTSMRSVTCILAQNSSQTLPGELRLSGRLQAQTGSLGGQASLRADTASLALVGVCTWGPGHGQLSGSLSHNISALSEAGLSSEAGILLSHTHVTSNFSVRVMLRSSGGQLDGALGLEGVATSAPGSQLRASLHHTVPGLGRWGLPFSVDGRGHLQLEGPSLEAGLVVSVDGEELGGAKERRGAGDGQELTLGLHPSLVRLQLP", "length": 2074, "header": "tr|A0AAA9SW86-1|A0AAA9T741_BOVIN Computationally mapped isoform of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=1 CANONICAL=A0AAA9T741-1" }, "locus": { "chromosome": "25", "start_pos": 10189185, "end_pos": 10085938, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124203.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124203.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088477.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088477.1" } ] } }, { "isoform_ac": "A0AAA9T741-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#A0AAA9T741-1", "sequence": { "sequence": "MPDSLVGQAASCMTSCTGSADPHLPVGTRYVYHFSTNTSTSLQGAQVGGSGLGLQGLVTLDVLGPCQMALQLQHFQLTSILGSKVEVLKQSESLSAVLGREPLRLVLQAGRVVRLCPRRAEPRWALNVKRAVLSLLQSHPGVRDPHTVEEVDILGRCPTTYQQLGSRLHKTKALGQCSLRRVRASLRSQALPAAEESGLASRLTCVQSLQAGVLREASCTQLDTAGPLSREASTAPMSTFSSLSLLQEVPLDPAVTERLTSDSDSGDLTPSSLLYEWEETPSQATVAAGAASVRRLCLAQATSFEATELFLTLVSELRGLSADELMELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQKDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGTIKVTADSAVLGFLLRDKHEKAGNSTSMRSVTCILAQNSSQTLPGELRLSGRLQAQTGSLGGQASLRADTASLALVGVCTWGPGHGQLSGSLSHNISALSEAGLSSEAGILLSHTHVTSNFSVRVMLRSSGGQLDGALGLEGVATSAPGSQLRASLHHTVPGLGRWGLPFSVDGRGHLQLEGPSLEAGLVVSVDGEELGGAKERRGAGDGQELTLGLHPSLVRLQNPAVLALNSSFLVHTFGASLVAQVSSGDTFARAHIHSACGHRAHLDTGLQHAWPPLQALGVPPNNHIRVSVGGDEPPRAQLEVALGLCTLTARGGFRSEASVTHNWTLALVNHCPLLEATGIPRALRSKGSLSWGPCEFDLTTDFHSDRGDAHLQLARSCGPQTLVLGHLAHSLPLLGRLGLPPRSAISLTVQTGPAPHSSLSLQMGPCQLQGALEQHTENQSTWMLATEPGCPLLEALGGEAEASGVLAAASQTASLTLVVTLHPSEATLRAKLRPALPAPHALPPETSLTVHCGWEAGHRLRLELHTGACELQGSGELQLDRRLQWRVVAESSCEGLQALGVPGRVNSSGYIVVNSTAMDAQVLVTVDASTLRGLLVLSTTETQQEVNLLLTHNLPQPNPLALPAQILLYLTNERLGPSYRHTLWVGVDGKEVSADVDSSGAGFENSGRVSSGSTSLNYSVSCHHRDGRLEFSGWSEHNSWALRQAGFPGEARLGAELQMQKTQTQARVVLQAGDDGISMDAVALVARPVNGPLELVVNVSHTAPLLRRLGLPFASQLMFRELWGKEEMHSSLQLTCDSQTSLVLNIQGHNQALSKELRLSGQHHLPVLLGRCPSRASASAKLRYSEGGAEGTFVLMVEEHHFHMGAGLAAAKNSLTNIIKLEQNFPQFHALPGELVLQTSYERARGTQVLHHTVLWDGQGVALKGSLNGSLSMPFLKPAGTLGLQVELTHPLPLPLPWHCSFRLTSEHSARRHQDDLVVGWDGKDQVALSSSLRLGKGKLAARLALAHPFSLSWRQAEASGLAESRGGRQSWQVQLAWNG", "length": 2894, "header": "tr|A0AAA9T741-1|A0AAA9T741_BOVIN Isoform 1 of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=1 CANONICAL=A0AAA9T741-1" }, "locus": { "chromosome": "25", "start_pos": 10189185, "end_pos": 10057256, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090932.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090932.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091633.1" } ] } }, { "isoform_ac": "A0AAA9TXQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#A0AAA9TXQ2-1", "sequence": { "sequence": "MSDEMPDSLVGQAASCMTSCTGSADPHLPVGTRYVYHFSTNTSTSLQGAQVGGSGLGLQGLVTLDVLGPCQMALQLQHFQLTSILGSKVEVLKQSESLSAVLGREPLRLVLQAGRVVRLCPRRAEPRWALNVKRAVLSLLQSHPGVRDPHTVEEVDILGRCPTTYQQLGSRLHKTKALGQCSLRRVRASLRSQALPAAEEQSGLASRLTCVQSLQAGVLREASCTQLDTAGPLSREASTAPMSTFSSLSLLQEVPLDPAVTERLTSDSDSGDLTPSSLLYEWEETPSQATVAAGAASVRRLCLAQATSFEATELFLTLVSELRGLSADELMELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQKDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGTIKVTADSAVLGFLLRDKHEKAGNSTSMRSVTCILAQNSSQTLPGELRLSGRLQAQTGSLGGQASLRADTASLALVGVCTWGPGHGQLSGSLSHNISALSEAGLSSEAGILLSHTHVTSNFSVRVMLRSSGGQLDGALGLEGVATSAPGSQLRASLHHTVPGLGRWGLPFSVDGRGHLQLEGPSLEAGLVVSVDGEELGGAKERRGAGDGQELTLGLHPSLVRLQNPAVLALNSSFLVHTFGASLVAQVSSGDTFARAHIHSACGHRAHLDTGLQHAWPPLQALGVPPNNHIRVSVGGDEPPRAQLEVALGLCTLTARGGFRSEASVTHNWTLALVNHCPLLEATGIPRALRSKGSLSWGPCEFDLTTDFHSDRGDAHLQLARSCGPQTLVLGHLAHSLPLLGRLGLPPRSAISLTVQTGPAPHSSLSLQMGPCQLQGALEQHTENQSTWMLATEPGCPLLEALGGEAEASGVLAAASQTASLTLVVTLHPSEATLRAKLRPALPAPHALPPETSLTVHCGWEAGHRLRLELHTGACELQGSGELQLDRRLQWRVVAESSCEGLQALGVPGRVNSSGYIVVNSTAMDAQVLVTVDASTLRGLLVLSTTETQQEVNLLLTHNLPQPNPLALPAQILLYLTNERLGPSYRHTLWVGVDGKELSLFHRLPIIRHVMPSVLSRPDSHCWCLSSTW", "length": 2542, "header": "tr|A0AAA9TXQ2-1|A0AAA9TXQ2_BOVIN Computationally mapped isoform of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=1 CANONICAL=A0AAA9T741-1" }, "locus": { "chromosome": "25", "start_pos": 10226351, "end_pos": 10074911, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103116.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103116.1" } ] } }, { "isoform_ac": "F1MSP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741/entry#F1MSP9-1", "sequence": { "sequence": "MPDSLVGQAASCMTSCTGSADPHLPVGTRYVYHFSTNTSTSLQGAQVGGSGLGLQGLVTLDVLGPCQMALQLQHFQLTSILGSKVEVLKQSESLSAVLGREPLRLVLQAGRVVRLCPRRAEPRWALNVKRAVLSLLQSHPGVRDPHTVEEVDILGRCPTTYQQLGSRLHKTKALGQCSLRRVRASLRSQALPAAEESGLASRLTCVQSLQAGVLREASCTQLDTAGPLSREASTAPMSTFSSLSLLQEVPLDPAVTERLTSDSDSGDLTPSSLLYEWEETPSQATVAAGAASVRRLCLAQATSFEATELFLTLVSELRGLSADELMELWGLSFKCRDNWQPLVDALPSCGTEACVGLMAELIMSGEVEADETEAWLWSLAFVPEPTDATVRVLLPLLQAPGASSSAFLGISALVHNLCVSLDGPCEQLSGVGSLVRILGDAVGANCTFWEPSDADQLLFVLKAIGNAGRAATALTPKLSTCASLGSCPPEIRLGAIQAFRRVPCSADRSVLSSLYQNAEEDPEIRINAYLALMRCPGEEVFAQVRRTQAREQSTQVGSFVWSHLLQLLETDDPLKQSLREAVPQDILSREFHPEVWKHSSYSDVTFRSASGSLGANLEGTLLFSPASFLPRSATANLTIHALGHAFNLLELGLRLENAEEMARRLFGPKSFWGQEEERQAQAKEPPEAEPGPTLQPADPACTGERSRKMRDLQQKVARRRGERQALKCQLSMKVFGHELSFVNCGAMGSHVTHQSLNLAELAIKLLKGQEVQVNRRLNLVMEELTFPTMSGLPARLTLNVSAAVSIRVRGTADFQQRSDFSVKGYVKPSALLQISAQMGTVGALGQAGLRWVTGVRGTASLDGGIQARKGQDLRVHLNTPEEVVELFRFSSQLYLITGDGVRSLNHVPSPSEAQSCTSKEAAHTWGWQLCTEVRWPAPDQPSLLSVPVFTAMTLKKQDQGLQQYLLEAAYTFHPQKDCWLPQEASAHIFMGTPESEVPRDVGVDISYSWPQGKFRLKLLHPKKRIELDGKIETVQRARMGHLELILDERDVYYIKGRSNLWPAVGGEAQRFEAQLEVKLVTSGSPVVLTGNLSRQAGSRLAFSVSLSNLLGDEARVSALLEKKVKDGLQVVSLGAELFVPGLVGLRALGQLQRLGHLWTSYLRIKYGLRGQAKQLAQECSTSQKLWAESGSEAAYKLELNHILHCTQIPAFSHKVQLRHEEGSGHLRWELEASYGKHWDDSRNRRRLLILHTFQNDSGPALSNHVLEFVLQVLERQVDYRMQLHHLSVRHPHVETSTHLKGQYNGRLPFVAGVQWKDTSRATLWKWEGALNLNSPWLMVSMAHRLYWPNRAMFQTVLELTLGKAWTLKNLVMNVACRGQGLRRQGKIHVYTPATTYLQVSTVTALAQSLFSSRSEIESAWSEAVQSEIHAENSQDRKILRCWLKGPQWELNLTAAYRHTEQPWKSHVLLTALGMGARGHPEGLQLEGILEELVQDRSLYRKQGTFSLRHPWTVPLPQRMLLQETFTADRRHQRYSLETRVVLGAQEETLQTVVLGYQAGHPYVCAGLTHPYDGRAIPRSLDGCMVLWNRHVAKNRGVEATLKVNQKVLLHLKALHHDRSRHGEVWHNLALGVAHSFQLRFPQALNVDGDVVFRQSHEGAFDCGVDARATINRNVTSQVLVQLNGSDSHSVVSFQLRRPRGPMFPPDLQVQAAAARYRERSVNGSLSVHVSGEELVLLEASARQDSRRNTRGWGMSVLLHQEVLRAPRAVQLQLSSKVAPARIWLFSKALLDQSTVQLFLKASEARRGGRVLTLRTQAQHTVAAWTALPRLLTLVGVLKQKEVLREGDWSSIPALERSTGEENGNPLQYSCLENSTDRAASRW", "length": 1882, "header": "tr|F1MSP9-1|A0AAA9T741_BOVIN Computationally mapped isoform of Vitellogenin domain-containing protein OS=Bos taurus OX=9913 GN=LOC616782 PE=4 SV=4 CANONICAL=A0AAA9T741-1" }, "locus": { "chromosome": "25", "start_pos": 10189185, "end_pos": 10102514, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046675.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046675.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043949.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043949.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T741", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T741" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1091, "end_pos": 1093, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1255, "end_pos": 1257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1451, "end_pos": 1453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1673, "end_pos": 1675, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1683, "end_pos": 1685, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1722, "end_pos": 1724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1870, "end_pos": 1872, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1884, "end_pos": 1886, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1941, "end_pos": 1943, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1966, "end_pos": 1968, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2079, "end_pos": 2081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2176, "end_pos": 2178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2292, "end_pos": 2294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2420, "end_pos": 2422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2428, "end_pos": 2430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2531, "end_pos": 2533, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2612, "end_pos": 2614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2782, "end_pos": 2784, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 445, "end_pos": 447, "annotation": "n_glycosylation_sequon" }, { "start_pos": 636, "end_pos": 638, "annotation": "n_glycosylation_sequon" }, { "start_pos": 799, "end_pos": 801, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], 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"crossref": [ { "id": "A0AAA9T8Z3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8Z3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011562", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011562", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524218", "url": "https://www.ncbi.nlm.nih.gov/gene/524218", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524218", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524218", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MLL2", "url": "https://www.orthodb.org/?gene=F1MLL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24355:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24355:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059738127", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738127", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLL2", "url": "https://www.uniprot.org/uniprotkb/F1MLL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MLL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYVCEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFQSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSSAVQSLVQLFSTVSVQYVPAWSKETVALLRKLLTVNPKHRVSSLQDMRAAPALAGVLWAELSEKKVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKSRSRDSSRDSCPSENDYLQDCLDAIQQDFVIFNREKLKRSQDPTPEPRDAAEALVDSEGVRPALPACGAICPSAGSS", "length": 364, "header": "tr|A0AAA9T8Z3-1|A0AAA9T8Z3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=STK32C PE=4 SV=1 CANONICAL=A0AAA9T8Z3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3/entry#A0AAA9SCJ3-1", "sequence": { "sequence": "MRSGAERRGSSAAAPPVSPPLGRGRLAGPDAPPAPPPPTSGQPRARDSSDARAQPRPLFQWTKWKKRMGSSMSAAAARRPVFDDKEDVNLDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYVCEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFQSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSSAVQSLVQLFSTVSVQYVPAWSKETVALLRKLLTVNPKHRVSSLQDMRAAPALAGVLWAELSEKKVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKSRSRDSSRDSCPSHVACGILVPDQDSTCLPSSEGGFLTTGPSQKSWFFFFSCCQTGSDGLEFFM", "length": 468, "header": "tr|A0AAA9SCJ3-1|A0AAA9T8Z3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=STK32C PE=4 SV=1 CANONICAL=A0AAA9T8Z3-1" }, "locus": { "chromosome": "26", "start_pos": 51927526, "end_pos": 51861394, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083107.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083107.1" } ] } }, { "isoform_ac": "A0AAA9SK84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3/entry#A0AAA9SK84-1", "sequence": { "sequence": "MRSGAERRGSSAAAPPVSPPLGRGRLAGPDAPPAPPPPTSGQPRARDSSDARAQPRPLFQWTKWKKRMGSSMSAAAARRPVFDDKEDVNLDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYVCEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFQSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSSAVQSLVQLFSTVSVQYVPAWSKETVALLRKLLTVNPKHRVSSLQDMRAAPALAGVLWAELSEKKVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKSRSRDSSRDSCPSENDYLQDCLDAIQQDFVIFNREKLKRSQDPTPEPRDAAEALVDSEGVRPALPACGAICPSAGSS", "length": 481, "header": "tr|A0AAA9SK84-1|A0AAA9T8Z3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=STK32C PE=4 SV=1 CANONICAL=A0AAA9T8Z3-1" }, "locus": { "chromosome": "26", "start_pos": 51927526, "end_pos": 51855538, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093542.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093542.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085720.1" } ] } }, { "isoform_ac": "A0AAA9T8Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3/entry#A0AAA9T8Z3-1", "sequence": { "sequence": "MYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYVCEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFQSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSSAVQSLVQLFSTVSVQYVPAWSKETVALLRKLLTVNPKHRVSSLQDMRAAPALAGVLWAELSEKKVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKSRSRDSSRDSCPSENDYLQDCLDAIQQDFVIFNREKLKRSQDPTPEPRDAAEALVDSEGVRPALPACGAICPSAGSS", "length": 364, "header": "tr|A0AAA9T8Z3-1|A0AAA9T8Z3_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=STK32C PE=4 SV=1 CANONICAL=A0AAA9T8Z3-1" }, "locus": { "chromosome": "26", "start_pos": 51868083, "end_pos": 51855538, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118665.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118665.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092362.1" } ] } }, { "isoform_ac": "F1MLL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3/entry#F1MLL2-1", "sequence": { "sequence": "MRSGAERRGSSAAAPPVSPPLGRGRLAGPDAPPAPPPPTSGQPRARDSSDARAQPRPLFQWTKWKKRMGSSMSAAAARRPVFDDKEDVNLDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYVCEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFQSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSSAVQSLVQLFSTVSVQYVPAWSKETVALLRKLLTVNPKHRVSSLQDMRAAPALAGVLWAELSEKKVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKSRSRDSSRDSCPSENDYLQDCLDAIQQDFVIFNREKQSLWGRPWAHRPG", "length": 453, "header": "tr|F1MLL2-1|A0AAA9T8Z3_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=STK32C PE=4 SV=4 CANONICAL=A0AAA9T8Z3-1" }, "locus": { "chromosome": "26", "start_pos": 51927526, "end_pos": 51855660, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015362.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015362.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015362.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015362.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:524218", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524218", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { 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"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": 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"https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { 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"ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": 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"uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", 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O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": 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"activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": 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"A0AAA9TE91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIN5", "url": "https://www.uniprot.org/uniprotkb/E1BIN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIN5-1", "url": "https://www.uniprot.org/uniprotkb/E1BIN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKKVVLRFVQVLGRSQCTEISLGEADTFMAIWGRISTRKATECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 806, "header": "tr|A0AAA9T669-1|A0AAA9T669_BOVIN Isoform 1 of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#A0A3Q1MRG1-1", "sequence": { "sequence": "MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 730, "header": "tr|A0A3Q1MRG1-1|A0A3Q1MRG1_BOVIN Computationally mapped isoform of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112699304, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069789.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069789.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072419.1" } ] } }, { "isoform_ac": "A0AAA9SCX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#A0AAA9SCX6-1", "sequence": { "sequence": "MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 702, "header": "tr|A0AAA9SCX6-1|A0AAA9T669_BOVIN Computationally mapped isoform of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112699304, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080160.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080160.1" } ] } }, { "isoform_ac": "A0AAA9SIB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#A0AAA9SIB7-1", "sequence": { "sequence": "MLCSNTLTTSVCLQNLSSATFQCTLQTLLCRNGLATQGEMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 785, "header": "tr|A0AAA9SIB7-1|A0AAA9T669_BOVIN Computationally mapped isoform of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112698652, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099830.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099830.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085077.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085077.1" } ] } }, { "isoform_ac": "A0AAA9T669-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#A0AAA9T669-1", "sequence": { "sequence": "MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKKVVLRFVQVLGRSQCTEISLGEADTFMAIWGRISTRKATECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 806, "header": "tr|A0AAA9T669-1|A0AAA9T669_BOVIN Isoform 1 of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112699304, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100732.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100732.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093369.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093369.1" } ] } }, { "isoform_ac": "A0AAA9TE91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#A0AAA9TE91-1", "sequence": { "sequence": "MLTLITWCPPDFSTVKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 696, "header": "tr|A0AAA9TE91-1|A0AAA9TE91_BOVIN Computationally mapped isoform of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=1 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112659876, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108234.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108234.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095225.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095225.1" } ] } }, { "isoform_ac": "E1BIN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669/entry#E1BIN5-1", "sequence": { "sequence": "MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLQESFNNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTGTQESSPTPQLKHQFFVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA", "length": 784, "header": "tr|E1BIN5-1|E1BIN5_BOVIN Computationally mapped isoform of Cullin-3 OS=Bos taurus OX=9913 GN=CUL3 PE=3 SV=3 CANONICAL=A0AAA9T669-1" }, "locus": { "chromosome": "2", "start_pos": 112699304, "end_pos": 112587198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029018.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029018.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029018.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029018.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-5632684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9013418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "resource": "Reactome", "description": "RHOBTB2 GTPase cycle" }, { "id": "R-BTA-9013422", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013422", "resource": "Reactome", "description": "RHOBTB1 GTPase cycle" }, { "id": "R-BTA-9706019", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9706019", "resource": "Reactome", "description": "RHOBTB3 ATPase cycle" }, { "id": "R-BTA-9755511", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9755511", "resource": "Reactome", "description": "KEAP1-NFE2L2 pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "id": "R-BTA-9929491", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929491", "resource": "Reactome", "description": "SPOP-mediated proteasomal degradation of PD-L1(CD274)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 36, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "response to stress", "id": "GO:0006950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006950", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "regulation of primary metabolic process", "id": "GO:0080090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "regulation of cellular response to insulin stimulus", "id": "GO:1900076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "embryonic cleavage", "id": "GO:0040016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "COPII vesicle coating", "id": "GO:0048208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048208", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T669", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T669" } ], "pmid": "" }, { "name": "positive 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"MAVREAAAGLSGPGRDEEAALLFENAHYRHDSRWLLPVSPRCCLACALELLPEPGVSLVRKKHVLSGFRDALMKHASLVVQLVAQDQRVCIHFVSMLFGLLCNVEDGSITDLCIEVLIQLTTQLKLEQTIHCLLDECHKELCSMPSMRGSLATLTLLGKLVDAVPALADKLVMEHGDLMEHLLRGLVYPNEGVQASVCYLYGKLYSSPVAAEMLLGHFREKLCPLFLSTMDGAQTKELQINCLGLLKQLLKYDLFVSMLMNKSALVESAESVEGPPGETPLPLVLKKLLLSRDETLQVASAQCITAVLVHSPAKHALAFIHADIPEFLFEHLSSSSEVLVWSCYNCLILLAEEPLFFSKCHTVYGIESVVRSLQGNLRMNNTELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALREAVSSPVLEVAAEALKAISAFLRKDHQSALPVLYKELQGLVKAMLSRCADLSQTPLNWRPLGHASNRNSERAILRRGKFLLNTLEGFRNACRLAMEFQREPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMVMRYWEQATHPAVMEVFLSVLHSLFVIVPHMKEKFSKKLAASSFIRLALELKARFCSGLSHSALNQVCSSFLYYMCISLFSAPEKTGPPSQEELCAVSELLQHGLPQISSRGPESLALLSDRQYVEEAARQRQYCILLLFYLAYIHEDRFVSKTKLFMAVQSFLLSLQDQGERPPLVVFRASIYLLAICQDKDDALDEAVVGAIRKFLEDTPDLHRVYTHHPLLLRLFLLHPELMRRFGHRVLELWFSWEESSYEELDGVPSAGQPTLPASVAALFHIFRSSPSILLILLDLICSSPMDIARKVLIVLKTFLRRNEDVQVGGLIRGHFLMILQHLLVEHGSSPSGASGNLPLLLNLLSLVQLRNESEQELDSMAMKLLHQVSKLCGTCSPADSDILQPSFNFLYCSLHQTTLGSQRRAAAVLLSSTALIELLEKMLALTWAEEGSPRTGLLCSAWLLTASFSAQQHKGSLQVHQTLSVELDQVLKALSVPKKKAALLSAAILRFLRTALQQNFSSALVALRPSGAQSPPAPEDTVLAPLGTSQVLSLVIGLQNLLVQKDPLLSHACVGCLEALLDYVHARSPDVALHVACQPWNRFLMFTLLEAGENSFLKPEILRLMTLFVRFRSSSILSQEVGHVLQGAASTDLSTLPGSTLQALHGFFLQVQSMGLLTDHSMAQTLQASLESLSPRASLAQPPLQDMLGPARWAGPESHGPQAGQMPPPTGRGRK", "length": 1285, "header": "tr|A0AAA9T6S2-1|A0AAA9T6S2_BOVIN Isoform 1 of Meiotic double-stranded break formation protein 1 OS=Bos taurus OX=9913 GN=MEI1 PE=4 SV=1 CANONICAL=A0AAA9T6S2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SD89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S2/entry#A0AAA9SD89-1", "sequence": { "sequence": "MAVREAAAGLSGPGRDEEAALLFENAHYRHDSRWLLPVSPRCCLACALELLPEPGVSLVRKKHVLSGFRDALMKHASLVVQLVAQDQRVCIHFVSMLFGLLCNVEDGSITDLCIEVLIQLTTQLKLEQTIHCLLDECHKELCSMPSMRGSLATLTLLGKLVDAVPALADKLVMEHGDLMEHLLRGLVYPNEGVQASVCYLYGKLYSSPVAAEMLLGHFREKLCPLFLSTMDGAQTKELQINCLGLLKQLLKYDLFVSMLMNKSALVESAESVEGPPGETPLPLVLKKLLLSRDETLQVASAQCITAVLVHSPAKHALAFIHADIPAQLVRTAPGGLPATVCCPETLPSPGKAGRRLLGTDPWPLLCHFEAGIESVVRSLQGNLRMNNTELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALREAVSSPVLEVAAEALKAISAFLRKDHQSALPVLYKELQGLVKAMLSRCADLSQTPLNWRPLGHASNRNSERAILRRGKFLLNTLEGFRNACRLAMEFQREPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMVMRYWEQATHPAVMEVFLSVLHSLFVIVPHMKEKFSKKLAASSFIRLALELKARFCSGLSHSALNQVCSSFLYYMCISLFSAPEKTGPPSQEELCAVSELLQHGLPQISSRGPESLALLSDRQYVEEAARQRQYCILLLFYLAYIHEDRFVSKTKLFMAVQSFLLSLQDQGERPPLVVFRASIYLLAICQDKDDALDEAVVGAIRKFLEDTPDLHRVYTHHPLLLRLFLLHPELMRRFGHRVLELWFSWEESSYEELDGVPSAGQPTLPASVAALFHIFRSSPSILLILLDLICSSPMDIARKVLIVLKTFLRRNEDVQVGGLIRGHFLMILQHLLVEHGSSPSGASGNLPLLLNLLSLVQLRNESEQELDSMAMKLLHQVSKLCGTCSPADSDILQPSFNFLYCSLHQTTLGSQRRAAAVLLSSTALIELLEKMLALTWAEEGSPRTGLLCSAWLLTASFSAQQHKGSLQVHQTLSVELDQVLKALSVPKKKAALLSAAILRFLRTALQQNFSSALVALRPSGAQSPPAPEDTVLAPLGTSQVLSLVIGLQNLLVQKDPLLSHACVGCLEALLDYVHARSPDVALHVACQPWNRFLMFTLLEAGENSFLKPEILRLMTLFVRFRSSSILSQEVGHVLQGAASTDLSTLPGSTLQALHGFFLQVQSMGLLTDHSMAQTLQASLESLSPRASLAQPPLQDMLCLGEVSVSLSHIRD", "length": 1278, "header": "tr|A0AAA9SD89-1|A0AAA9T6S2_BOVIN Computationally mapped isoform of Meiotic double-stranded break formation protein 1 OS=Bos taurus OX=9913 GN=MEI1 PE=4 SV=1 CANONICAL=A0AAA9T6S2-1" }, "locus": { "chromosome": "5", "start_pos": 112811479, "end_pos": 112755822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127790.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127790.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080290.1" } ] } }, { "isoform_ac": "A0AAA9SR32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S2/entry#A0AAA9SR32-1", "sequence": { "sequence": "MAVREAAAGLSGPGRDEEAALLFENAHYRHDSRWLLPVSPRCCLACALELLPEPGVSLVRKKHVLSGFRDALMKHASLVVQLVAQDQRVCIHFVSMLFGLLCNVEDGSITDLCIEVLIQLTTQLKLEQTIHCLLDECHKELCSMPSMRGSLATLTLLGKLVDAVPALADKLVMEHGDLMEHLLRGLVYPNEGVQASVCYLYGKLYSSPVAAEMLLGHFREKLCPLFLSTMDGAQTKELQINCLGLLKQLLKYDLFVSMLMNKSALVESAESVEGPPGETPLPLVLKKAGIESVVRSLQGNLRMNNTELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALREAVSSPVLEVAAEALKAISAFLRKDHQSALPVLYKELQGLVKAMLSRCADLSQTPLNWRPLGHASNRNSERAILRRGKFLLNTLEGFRNACRLAMEFQREPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMVMRYWEQATHPAVMEVFLSVLHSLFVIVPHMKEKFSKKLAASSFIRLALELKARFCSGLSHSALNQVCSSFLYYMCISLFSAPEKTGPPSQEELCAVSELLQHGLPQISSRGPESLALLSDRQYVEEAARQRQYCILLLFYLAYIHEDRFVSKTKLFMAVQSFLLSLQDQGERPPLVVFRASIYLLAICQDKDDALDEAVVGAIRKFLEDTPDLHRVYTHHPLLLRLFLLHPELMRRFGHRVLELWFSWEESSYEELDGVPSAGQPTLPASVAALFHIFRSSPSILLILLDLICSSPMDIARKVLIVLKTFLRRNEDVQVGGLIRGHFLMILQHLLVEHGSSPSGASGNLPLLLNLLSLVQLRNESEQELDSMAMKLLHQVSKLCGTCSPADSDILQPSFNFLYCSLHQTTLGSQRRAAAVLLSSTALIELLEKMLALTWAEEGSPRTGLLCSAWLLTASFSAQQHKGSLQVHQTLSVELDQVLKALSVPKKKAALLSAAILRFLRTALQQNFSSALVALRPSGAQSPPAPEDTVLAPLGTSQVLSLVIGLQNLLVQKDPLLSHACVGCLEALLDYVHARSPDVALHVACQPWNRFLMFTLLEAGENSFLKPEILRLMTLFVRFRSSSILSQEVGHVLQGAASTDLSTLPGSTLQALHGFFLQVQSMGLLTDHSMAQTLQASLESLSPRASLAQPPLQDMLCLGEVSVSLSHIRD", "length": 1196, "header": "tr|A0AAA9SR32-1|A0AAA9T6S2_BOVIN Computationally mapped isoform of Meiotic double-stranded break formation protein 1 OS=Bos taurus OX=9913 GN=MEI1 PE=4 SV=1 CANONICAL=A0AAA9T6S2-1" }, "locus": { "chromosome": "5", "start_pos": 112811479, "end_pos": 112755822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096380.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096380.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086434.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086434.1" } ] } }, { "isoform_ac": "A0AAA9T6S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S2/entry#A0AAA9T6S2-1", "sequence": { "sequence": "MAVREAAAGLSGPGRDEEAALLFENAHYRHDSRWLLPVSPRCCLACALELLPEPGVSLVRKKHVLSGFRDALMKHASLVVQLVAQDQRVCIHFVSMLFGLLCNVEDGSITDLCIEVLIQLTTQLKLEQTIHCLLDECHKELCSMPSMRGSLATLTLLGKLVDAVPALADKLVMEHGDLMEHLLRGLVYPNEGVQASVCYLYGKLYSSPVAAEMLLGHFREKLCPLFLSTMDGAQTKELQINCLGLLKQLLKYDLFVSMLMNKSALVESAESVEGPPGETPLPLVLKKLLLSRDETLQVASAQCITAVLVHSPAKHALAFIHADIPEFLFEHLSSSSEVLVWSCYNCLILLAEEPLFFSKCHTVYGIESVVRSLQGNLRMNNTELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALREAVSSPVLEVAAEALKAISAFLRKDHQSALPVLYKELQGLVKAMLSRCADLSQTPLNWRPLGHASNRNSERAILRRGKFLLNTLEGFRNACRLAMEFQREPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMVMRYWEQATHPAVMEVFLSVLHSLFVIVPHMKEKFSKKLAASSFIRLALELKARFCSGLSHSALNQVCSSFLYYMCISLFSAPEKTGPPSQEELCAVSELLQHGLPQISSRGPESLALLSDRQYVEEAARQRQYCILLLFYLAYIHEDRFVSKTKLFMAVQSFLLSLQDQGERPPLVVFRASIYLLAICQDKDDALDEAVVGAIRKFLEDTPDLHRVYTHHPLLLRLFLLHPELMRRFGHRVLELWFSWEESSYEELDGVPSAGQPTLPASVAALFHIFRSSPSILLILLDLICSSPMDIARKVLIVLKTFLRRNEDVQVGGLIRGHFLMILQHLLVEHGSSPSGASGNLPLLLNLLSLVQLRNESEQELDSMAMKLLHQVSKLCGTCSPADSDILQPSFNFLYCSLHQTTLGSQRRAAAVLLSSTALIELLEKMLALTWAEEGSPRTGLLCSAWLLTASFSAQQHKGSLQVHQTLSVELDQVLKALSVPKKKAALLSAAILRFLRTALQQNFSSALVALRPSGAQSPPAPEDTVLAPLGTSQVLSLVIGLQNLLVQKDPLLSHACVGCLEALLDYVHARSPDVALHVACQPWNRFLMFTLLEAGENSFLKPEILRLMTLFVRFRSSSILSQEVGHVLQGAASTDLSTLPGSTLQALHGFFLQVQSMGLLTDHSMAQTLQASLESLSPRASLAQPPLQDMLGPARWAGPESHGPQAGQMPPPTGRGRK", "length": 1285, "header": "tr|A0AAA9T6S2-1|A0AAA9T6S2_BOVIN Isoform 1 of Meiotic double-stranded break formation protein 1 OS=Bos taurus OX=9913 GN=MEI1 PE=4 SV=1 CANONICAL=A0AAA9T6S2-1" }, "locus": { "chromosome": "5", "start_pos": 112813711, "end_pos": 112755822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130285.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130285.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093597.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093597.1" } ] } }, { "isoform_ac": "E1BFW3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S2/entry#E1BFW3-1", "sequence": { "sequence": "MAVREAAAGLSGPGRDEEAALLFENAHYRHDSRWLLPVSPRCCLACALELLPEPGVSLVRKKHVLSGFRDALMKHASLVVQLVAQDQRVCIHFVSMLFGLLCNVEDGSITDLCIEVLIQLTTQLKLEQTIHCLLDECHKELCSMPSMRGSLATLTLLGKLVDAVPALADKLVMEHGDLMEHLLRGLVYPNEGVQASVCYLYGKLYSSPVAAEMLLGHFREKLCPLFLSTMDGAQTKELQINCLGLLKQLLKYDLFVSMLMNKSALVESAESVEGPPGETPLPLVLKKLLLSRDETLQVASAQCITAVLVHSPAKHALAFIHADIPEFLFEHLSSSSEVLVWSCYNCLILLAEEPLFFSKCHTVYGIESVVRSLQGNLRMNNTELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALREAVSSPVLEVAAEALKAISAFLRKDHQSALPVLYKELQGLVKAMLSRCADLSQTPLNWRPLGHASNRNSERAILRRGKFLLNTLEGFRNACRLAMEFQREPSAQENPFTAPSAEKEDTLEAFSEFLLSACDSLCIPMVMRYWEQATHPAVMEVFLSVLHSLFVIVPHMKEKFSKKLAASSFIRLALELKARFCSGLSHSALNQVCSSFLYYMCISLFSAPEKTGPPSQEELCAVSELLQHGLPQISSRGPESLALLSDRQYVEEAARQRQYCILLLFYLAYIHEDRFVSKTKLFMAVQSFLLSLQDQGERPPLVVFRASIYLLAICQDKDDALDEAVVGAIRKFLEDTPDLHRVYTHHPLLLRLFLLHPELMRRFGHRVLELWFSWEESSYEELDGVPSAGQPTLPASVAALFHIFRSSPSILLILLDLICSSPMDIARKVLIVLKTFLRRNEDVQVGGLIRGHFLMILQHLLVEHGSSPSGGQPVAAGASGNLPLLLNLLSLVQLRNESEQELDSMAMKLLHQVSKLCGTCSPADSDILQPSFNFLYCSLHQTTLGSQRRAAAVLLSSTALIELLEKMLALTWAEEGSPRTGLLCSAWLLTASFSAQQHKGSLQVHQTLSVELDQVLKALSVPKKKAALLSAAILRFLRTALQQNFSSALVALRPSGAQSPPAPEDTVLAPLGTSQVLSLVIGLQNLLVQKDPLLSHACVGCLEALLDYVHARSPDVALHVACQPWNRFLMFTLLEAGENSFLKPEILRLMTLFVRFRSSSILSQEVGHVLQGAASTDLSTLPGSTLQALHGFFLQVQSMGLLTDHSMAQTLQASLESLSPRASLAQPPLQDMLCLGEVSVSLSHIRD", "length": 1279, "header": "tr|E1BFW3-1|A0AAA9T6S2_BOVIN Computationally mapped isoform of Meiotic double-stranded break formation protein 1 OS=Bos taurus OX=9913 GN=MEI1 PE=4 SV=4 CANONICAL=A0AAA9T6S2-1" }, "locus": { "chromosome": "5", "start_pos": 112811479, "end_pos": 112755822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028212.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028212.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028212.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028212.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "meiosis I", "id": "GO:0007127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007127", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6S2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1069, "end_pos": 1071, "annotation": "n_glycosylation_sequon" }, { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 921, "end_pos": 923, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1069, "end_pos": 1071 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 921, "end_pos": 923 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T569-1", "uniprot_ac": "A0AAA9T569", "uniprot_id": "MRP4_BOVIN", "mass": { "chemical_mass": 148074.0, "monoisotopic_mass": 148074.0 }, "refseq": {}, "gene_names": [ { "name": "ABCC4", "type": "recommended", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "name": "LOC515333", "type": "recommended", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "name": "MOATB", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] }, { "name": "MRP4", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ] } ], "protein_names": [ { "name": "ATP-binding cassette sub-family C member 4", "type": "recommended", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.3", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#names_and_taxonomy" } ] }, { "name": "Multidrug resistance-associated protein 4", "type": "synonym", "evidence": [ { "id": "A0AAA9T569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:38216659). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (By similarity). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (By similarity). Mediates the cotransport of bile acids with reduced glutathione (GSH) (By similarity). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (By similarity). Confers resistance to anticancer agents such as methotrexate (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569#function" }, { "database": "PubMed", "id": "38216659", "url": "https://glygen.org/publication/PubMed/38216659" }, { "database": "UniProtKB", "id": "O15439", "url": "https://www.uniprot.org/uniprotkb/O15439#function" }, { "database": "UniProtKB", "id": "A0AAA9SF74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF74#function" }, { "database": "UniProtKB", "id": "ARBA00094206", "url": "https://www.uniprot.org/uniprotkb/ARBA00094206#function" }, { "database": "UniProtKB", "id": "G3MW12", "url": "https://www.uniprot.org/uniprotkb/G3MW12#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000032603", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032603", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515333", "url": "https://www.ncbi.nlm.nih.gov/gene/515333", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8SWN", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SWN&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8SX7", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SX7&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8SX8", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SX8&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8SX9", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SX9&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "8SXA", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=8SXA&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ACAQWFH", "url": "https://omabrowser.org/oma/group/ACAQWFH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MUC1", "url": "https://www.orthodb.org/?gene=F1MUC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MW12", "url": "https://www.orthodb.org/?gene=G3MW12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00008swn", "url": "https://www.rcsb.org/structure/pdb_00008swn", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008sx7", "url": "https://www.rcsb.org/structure/pdb_00008sx7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008sx8", "url": "https://www.rcsb.org/structure/pdb_00008sx8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008sx9", "url": "https://www.rcsb.org/structure/pdb_00008sx9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00008sxa", "url": "https://www.rcsb.org/structure/pdb_00008sxa", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SWN", "url": "https://www.rcsb.org/structure/8SWN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SX7", "url": "https://www.rcsb.org/structure/8SX7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SX8", "url": "https://www.rcsb.org/structure/8SX8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SX9", "url": "https://www.rcsb.org/structure/8SX9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8SXA", "url": "https://www.rcsb.org/structure/8SXA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9748787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9753281", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "16461", "url": "https://www.rhea-db.org/rhea/16461", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19121", "url": "https://www.rhea-db.org/rhea/19121", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "38963", "url": "https://www.rhea-db.org/rhea/38963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "60128", "url": "https://www.rhea-db.org/rhea/60128", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61364", "url": "https://www.rhea-db.org/rhea/61364", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66184", "url": "https://www.rhea-db.org/rhea/66184", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66188", "url": "https://www.rhea-db.org/rhea/66188", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66380", "url": "https://www.rhea-db.org/rhea/66380", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66388", "url": "https://www.rhea-db.org/rhea/66388", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66392", "url": "https://www.rhea-db.org/rhea/66392", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66396", "url": "https://www.rhea-db.org/rhea/66396", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66400", "url": "https://www.rhea-db.org/rhea/66400", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66404", "url": "https://www.rhea-db.org/rhea/66404", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66408", "url": "https://www.rhea-db.org/rhea/66408", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66412", "url": "https://www.rhea-db.org/rhea/66412", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66416", "url": "https://www.rhea-db.org/rhea/66416", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66420", "url": "https://www.rhea-db.org/rhea/66420", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66424", "url": "https://www.rhea-db.org/rhea/66424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SF74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T569-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUC1", "url": "https://www.uniprot.org/uniprotkb/F1MUC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MUC1-1", "url": "https://www.uniprot.org/uniprotkb/F1MUC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MW12", "url": "https://www.uniprot.org/uniprotkb/G3MW12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MW12-1", "url": "https://www.uniprot.org/uniprotkb/G3MW12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCSLPAPPSMGFYRWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLGIFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTLVLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLIILLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFADLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVITASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEITQLHSQLPSDGKMIVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKDGQMVQKGTYTEFLKSGIDFGSLLKKENEEAEPSPVPGSPTLRNRTFSESSVWSQQSSRPSLKEATPEGQDTENIQVTLTEESRSEGKVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYWANQQSALNVTVNGQGNVTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTLHNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTFLQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTALIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITHNGHVVMNASSGQPSAFTIFETAL", "length": 1315, "header": "sp|A0AAA9T569-1|MRP4_BOVIN Isoform 1 of ATP-binding cassette sub-family C member 4 OS=Bos taurus OX=9913 GN=ABCC4 PE=1 SV=1 CANONICAL=A0AAA9T569-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#A0AAA9SF74-1", "sequence": { "sequence": "MQPVYPEVKPNPLRNANLCSRIFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLGIFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTLVLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLIILLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFADLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVITASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEITQLHSQLPSDGKMIVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKDGQMVQKGTYTEFLKSGIDFGSLLKKENEEAEPSPVPGSPTLRNRTFSESSVWSQQSSRPSLKEATPEGQDTENIQVTLTEESRSEGKVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYWANQQSALNVTVNGQGNVTEKLDLNWYLGIYSGRILNRFSKDIGHMDDLLPLTYLDFIQTFLQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTALIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITHNGHVVMNASSGQPSAFTIFETAL", "length": 1276, "header": "tr|A0AAA9SF74-1|MRP4_BOVIN Computationally mapped isoform of ATP-binding cassette sub-family C member 4 OS=Bos taurus OX=9913 GN=ABCC4 PE=1 SV=1 CANONICAL=A0AAA9T569-1" }, "locus": { "chromosome": "12", "start_pos": 69666089, "end_pos": 69482280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101068.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101068.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084027.1" } ] } }, { "isoform_ac": "A0AAA9T569-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#A0AAA9T569-1", "sequence": { "sequence": "MDCSLPAPPSMGFYRWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLGIFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTLVLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLIILLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFADLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVITASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEITQLHSQLPSDGKMIVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKDGQMVQKGTYTEFLKSGIDFGSLLKKENEEAEPSPVPGSPTLRNRTFSESSVWSQQSSRPSLKEATPEGQDTENIQVTLTEESRSEGKVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYWANQQSALNVTVNGQGNVTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTLHNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTFLQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTALIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITHNGHVVMNASSGQPSAFTIFETAL", "length": 1315, "header": "sp|A0AAA9T569-1|MRP4_BOVIN Isoform 1 of ATP-binding cassette sub-family C member 4 OS=Bos taurus OX=9913 GN=ABCC4 PE=1 SV=1 CANONICAL=A0AAA9T569-1" }, "locus": {} }, { "isoform_ac": "F1MUC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#F1MUC1-1", "sequence": { "sequence": "MQPVYPEVKPNPLRNANLCSRIFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLGIFTLIEALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLIILLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFADLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVITASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEITQLHSQLPSDGKMIVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKDGQMVQKGTYTEFLKSGIDFGSLLKKENEEAEPSPVPGSPTLRNRTFSESSVWSQQSSRPSLKEATPEGQDTENIQVTLTEESRSEGKVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYWANQQSALNVTVNGQGNVTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTLHNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTFLQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTALIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITHNGHVVMNASSGQPSAFTIFETAL", "length": 1250, "header": "tr|F1MUC1-1|F1MUC1_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 4 OS=Bos taurus OX=9913 GN=LOC515333 PE=3 SV=3 CANONICAL=A0AAA9T569-1" }, "locus": { "chromosome": "12", "start_pos": 69666089, "end_pos": 69482280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013298.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013298.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013298.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013298.6" } ] } }, { "isoform_ac": "G3MW12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569/entry#G3MW12-1", "sequence": { "sequence": "MQPVYPEVKPNPLRNANLCSRIFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLGIFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTLVLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLIILLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFADLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVITASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEITQLHSQLPSDGKMIVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKDGQMVQKGTYTEFLKSGIDFGSLLKKENEEAEPSPVPGSPTLRNRTFSESSVWSQQSSRPSLKEATPEGQDTENIQVTLTEESRSEGKVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYWANQQSALNVTVNGQGNVTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTLHNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTFLQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEQRFQELFDSHQDLHSALDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTALIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITHNGHVVMNASSGQPSAFTIFETAL", "length": 1288, "header": "tr|G3MW12-1|G3MW12_BOVIN Computationally mapped isoform of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC515333 PE=3 SV=3 CANONICAL=A0AAA9T569-1" }, "locus": { "chromosome": "12", "start_pos": 69666089, "end_pos": 69482280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035486.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035486.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035361.6", "url": "https://www.ensembl.org/id/ENSBTAP00000035361.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 638, "end_pos": 638, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "site_lbl": "Thr638" }, { "start_pos": 654, "end_pos": 654, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "site_lbl": "Ser654" }, { "start_pos": 658, "end_pos": 658, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "site_lbl": "Ser658" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Structural basis of prostaglandin efflux by MRP4.", "journal": "Nature structural & molecular biology", "date": "2024-04", "authors": "Pourmal Sergei, Green Evan, Bajaj Ruchika, Chemmama Ilan E, Knudsen Giselle M, Gupta Meghna, Sali Andrej, Cheng Yifan, Craik Charles S, Kroetz Deanna L, Stroud Robert M", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "reference": [ { "type": "PubMed", "id": "38216659", "url": "https://glygen.org/publication/PubMed/38216659" } ] } ], "pathway": [ { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-9748787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "resource": "Reactome", "description": "Azathioprine ADME" }, { "id": "R-BTA-9753281", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "resource": "Reactome", "description": "Paracetamol ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BBR6-1", "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "ABCC4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPVYPEVKPNPLRDANVCSRVLFCWLNPLFRVGYKRRLEEDDMYSVLPEDRSAHLGEELRGYWDQEVSRAEKDAREPSLIKAIIKCYWKPYLVLGIFTFLEESTKVVQPIFLGKIIAYFENYDPTDSVALYETYGYAGGLSTCVLLLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNLAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQALIVTALLWMEIGISCLAGMAVLIILLPLQSCLGKLFSSLRSKTAAYTDVRIRTMNEVITGIRIIKMYAWEKSFADLIARLRSKEISKILRSSYLRGMNLASFFVASKIIVFITFTTYVLLGNVITARRVFVAVTLYAAVRLTVTLFFPSAVEKVSEAIVSIRRIKDFLLLDEIPQCNSQLPPDGKTIVHVQDFTAFWEKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELRPSQGLVTVRGRIAYVSQQPWVFSGTVRSNILFGKTYEKERYEKVIKACALRKDLQLLEDGDLTVIGDRGTTLSGGQKARISLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQALHEKITILVTHQLQYLKAASQILILKDGKTVEKGTYTEFLKSGIDFGSLLKKENEEAEPSPMPGTPTLRNRTFSESSIWSQQSSRPSLKDATPEGQDTENIQVALPEESRSEGEVGFKAYKNYFTAGAHWFIIIFLILVNVAAQVSYVLQDWWLSYWANKQSSLNVTVVGNGTETQKLDLNWYLGIYSGLTVSTVLFGIARSLLVFYVLVSSSQSLHNKMFESILRAPILFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTFLQVMGVVGVAVAVIPWIAIPLIPLGIIFFVLRRYFLQTSRDVKRLEATTRSPVFSHLSSSLQGLWTIRAFKAEQRFQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIVVAFGSLILSKTLDAGQVGLALSYALSLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPTWPHEGVIVFDNVNFSYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWDALKEVQLKEAVEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDEATANVDPRTDELIQKKIREKFAQCTVLTIAHRLNTVIDSDKIMVLDAGRLKEYDEPYVLLQNRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYPDITQNGPVVMNASNGQPSAFTVFETAL", "length": 1325 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E9Q236-1", "protein_name": "ATP-binding cassette sub-family C member 4", "gene_name": "Abcc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCYWKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLDELPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECKKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTIFETAL", "length": 1325 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O15439-1", "protein_name": "ATP-binding cassette sub-family C member 4", "gene_name": "ABCC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL", "length": 1325 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54LE6-1", "protein_name": "ABC transporter C family member 5", "gene_name": "abcC5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKYNNLENDDSDIHNNNNNNESEGDSLIELEEINLEGNNNNDINNNNNINNNNDSLDYENNKGSKKKNNKKYVILNEEEDINDKKVENGENETSSFTYGHDNEFKDLPLPKKGFGGLKSLEENANFLSSMTYLWADKFVLYCFKNILQLDEIWELASYDKSSYLFDIMDKNWQNELKNSKKPNFMKAAFKSFGKHFALSWVHFGLNVISQFIGPIFLKKIVSFVIQYRENPGSVDPNLGYYYALILFVNSMLGSIFLYQSNMITSRTGNRLKSLIVLYVYKKSLKLTNSSRSKKSNGEIVNLMSNDAQRLLELFQMVNTLIFAVPMIIVSMILLYDCVGWPSFVALLVMGISLPYSLNRGSQLSIYRRKLVGFTDQRIKVVNEMFQAIKTIKLYAWEDYFSQKMMSKRGEEIKFLTQFVRFRYSLIVVVQSIPTIISIFMFTVYYLVNSKLPADKIFAAVAYLNIIRVPFTFLPYGYNIYIQFKVSIERVVNFLNMDEINQGDDKNNEINVNVCDQQKQQQTDIGIYMDNTTFSWAIKPQTNPPPPRTTPSNDKSSPSGNNSNNEKKEVQVSFSLKNTSCQVKEKGSLLMVIGPVGSGKSSFCQALLGEMELENNGSLRVVGSIAYVSQSAWIMNASLKDNILFGKEYNKERYEMVLNCCALLPDLALFPQGDLIEIGERGINLSGGQKQRVAIARAVYSDSDIYILDDILSAVDAHVGKHLFYNCIKGILKEKIVVLATNQLNYCPYSTQTLILKTGGEVEQYDTFENIISTINSAYGNSSLFSELLKQYAHMAGDSDKDSDEIVDDEMIKSKENNNDLYDGKLTTIEEREEGSVSFKHYMYYVTAGGGFLFLIALLGYCIDTSTSTFTNWWLSNWSSKHTSTGINNNNSSSSNSISSSSSYIIDSLSSLNINEDGDIENAGEFLGVFIAIGVLTVLLIIVRTIVFFEYSIRATTEIHKRLFWSILRAPMWFFDTVPLGRILNRFTRDTDIVDMLLTNSLNQFLNFSTNCIAILVIISIATPWLLLPMTPIIILFYFIQYFYRRTSIQIQRIESITRSPIFSHFAETLNGVITLRAFRKMGENVLKNQALLDDNNKCYLTLQAMNQWLGLRLSVLGNLITLLSCIFITVDRSSIAIASVGLSISYTLSLTTNLNKATQQLAELETKMNSIERISYYTENVPQEPDQIIESNRPPMGWPSLTNSNHTPPIIFENVVMSYRQGLPAVLKGISFEIKAGEKIGICGRTGSGKSSLLLALFRIVELSSGRIIIDGLDISKIGLKDLRSQLAIIPQEPVMFTGTLRSNLDSLSEHTDSELWDVLKEIQLYEHVKKVSVADEGLDLRVNDNWSQGQKQLIGLGRALLKKPKILVCDEATASVDSLSDELIQRIIREKFKDAIILTIAHRLNTIVESDRIMVLDSGSIVEFNKPSILAQNENSLFNWLIDETGTQNSQYLRSLIKH", "length": 1460 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9M1C7-1", "protein_name": "ABC transporter C family member 9", "gene_name": "ABCC9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MFKPFGFAAETGSHLLTTQWLQLGNSLCLKERISIAMQVTFLAFFLIHLALKWFGVVRNRGSNDVEEDLKKQSITVKQSFSYNISLLCSVSILGTHCFILLLLFRDSVVSRCDSSVSVFSAEVSQSFSWLFVSVVVVKIRERRLVKFPWMLRSWWLCSFILSFSFDAHFITAKHEPLEFQDYADLTGLLASLFLLAVSIRGKTGFHLLESSGNTEPLLLGDQTEQNKKDSYSSSSPYGNATLFQRITFSWINPLFSLGYKRPLEKDDVPDIDVKDSARFCSHAFDQKLKTTKEKEGPGNAFFYNSVLRYVWRKAAINAVFAVVNASTAYIGPYLINDFVEFLSEKQSQSLNHGYLLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLSSQSRQSHTSGEIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQSDIMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQAFTTFILWGAPSLISVVTFVTCMLMGVKLTAGAVLSALATFQMLQSPIFGLPDLLSALVQSKVSADRIASYLQQSETQKDAVEYCSKDHTELSVEIENGAFSWEPESSRPTLDDIELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIRDNILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEELLKQNIGFEVLVGAHNEALDSILSIEKSSRNFKEGSKDDTASIAESLQTHCDSEHNISTENKKKEAKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVPFIILAQSCFQMLQIASNYWMAWTAPPTAESIPKLGMGRILLVYALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAPMSFFDSTPTGRILNRASTDQSVLDLEMAVKLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIPVAVACVFYQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHVASAMEWLSFRLNLLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNICNAENKMISVERILQYSKIPSEAPLVIDGHRPLDNWPNVGSIVFRDLQVRYAEHFPAVLKNITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIPQDPALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQLVCLGRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFDSPAKLLQREDSFFSKLIKEYSLRSNHFAGSNDLLS", "length": 1506 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VLN6-1", "protein_name": "Uncharacterized protein", "gene_name": "Dme_CG7627", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQSLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENRQNHSLSS", "length": 1355 }, "evidence": [ { "id": "A0AAA9T569", "url": "https://omabrowser.org/oma/group/A0AAA9T569/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "ABC-type glutathione S-conjugate transporter activity", "id": "GO:0015431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015431", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T569", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T569" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1166, "end_pos": 1168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1299, "end_pos": 1301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 641, "end_pos": 643, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 744, "end_pos": 746, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16461", "name": "", "equation": "urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MUG0-1", "Q4GZT4-1", "A0AAA9T569-1" ], "evidence": [ { "id": "16461", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16461" } ] }, { "id": "19121", "name": "", "equation": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8HXQ5-1", "G5E626-1", "A0AAA9T569-1", "F1MPV3-1" ], "evidence": [ { "id": "19121", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19121" } ] }, { "id": "38963", "name": "", "equation": "leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8HXQ5-1", "A0A3Q1NLJ8-1", "F1N3Y6-1", "G5E626-1", "A0AAA9T569-1", "F1MPV3-1" ], "evidence": [ { "id": "38963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38963" } ] }, { "id": "60128", "name": "", "equation": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8HXQ5-1", "A0A3Q1MUG0-1", "Q4GZT4-1", "A0A3Q1NLJ8-1", "A0AAA9T569-1", "F1N3Y6-1" ], "evidence": [ { "id": "60128", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60128" } ] }, { "id": "61364", "name": "", "equation": "dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MUG0-1", "Q4GZT4-1", "A0AAA9T569-1" ], "evidence": [ { "id": "61364", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61364" } ] }, { "id": "66184", "name": "", "equation": "3',5'-cyclic AMP(in) + ATP + H2O = 3',5'-cyclic AMP(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1", "F1MZD4-1" ], "evidence": [ { "id": "66184", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66184" } ] }, { "id": "66188", "name": "", "equation": "3',5'-cyclic GMP(in) + ATP + H2O = 3',5'-cyclic GMP(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1", "F1MZD4-1" ], "evidence": [ { "id": "66188", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66188" } ] }, { "id": "66380", "name": "", "equation": "glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66380", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66380" } ] }, { "id": "66388", "name": "", "equation": "prostaglandin E2(in) + ATP + H2O = prostaglandin E2(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66388", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66388" } ] }, { "id": "66392", "name": "", "equation": "prostaglandin E1(in) + ATP + H2O = prostaglandin E1(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66392", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66392" } ] }, { "id": "66396", "name": "", "equation": "cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66396", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66396" } ] }, { "id": "66400", "name": "", "equation": "glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66400", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66400" } ] }, { "id": "66404", "name": "", "equation": "taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66404", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66404" } ] }, { "id": "66408", "name": "", "equation": "glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66408", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66408" } ] }, { "id": "66412", "name": "", "equation": "taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66412", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66412" } ] }, { "id": "66416", "name": "", "equation": "glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66416", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66416" } ] }, { "id": "66420", "name": "", "equation": "tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T569-1" ], "evidence": [ { "id": "66420", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66420" } ] }, { "id": "66424", "name": "", "equation": "leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZT1-1", "A0AAA9T569-1", "A0AAA9SJG6-1", "A0AAA9TUR1-1", "A0AAA9S3M4-1", "G3MW08-1", "A0AAA9TZ11-1", "A0A3Q1LXZ2-1", "A0AAA9T4S3-1", "A0A3Q1LPI1-1", "A0AAA9TR50-1", "A0A3Q1ML89-1", "A0AAA9SMB4-1" ], "evidence": [ { "id": "66424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66424" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LPI1", "gene_name": "LOC107131247", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] } ] }, { "uniprot_ac": "A0A3Q1LXZ2", "gene_name": "LOC521568", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] } ] }, { "uniprot_ac": "A0A3Q1ML89", "gene_name": "LOC100299180", "activity": [ { "ec_number": "7.6.2.2", "activity": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7D7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJ27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJ27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF38", "url": "https://www.uniprot.org/uniprotkb/F1MF38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF38-1", "url": "https://www.uniprot.org/uniprotkb/F1MF38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAMPIKENNKGNQICVDRGIMLQRNVTLEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 386, "header": "tr|A0AAA9T6P6-1|A0AAA9T6P6_BOVIN Isoform 1 of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9SGX1-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAMPIKENNKGNQICVDRGIMLQRNVTLVEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 417, "header": "tr|A0AAA9SGX1-1|A0AAA9T6P6_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082944.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082944.1" } ] } }, { "isoform_ac": "A0AAA9SQB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9SQB2-1", "sequence": { "sequence": "MSKQVWPYLIHHGGKAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 368, "header": "tr|A0AAA9SQB2-1|A0AAA9T6P6_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28667950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106036.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106036.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088522.1" } ] } }, { "isoform_ac": "A0AAA9SSA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9SSA1-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTVEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 390, "header": "tr|A0AAA9SSA1-1|A0AAA9T6P6_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=2 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109510.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109510.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086988.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086988.2" } ] } }, { "isoform_ac": "A0AAA9T0N0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9T0N0-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTVEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 360, "header": "tr|A0AAA9T0N0-1|A0AAA9T6P6_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099676.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099676.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089931.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089931.1" } ] } }, { "isoform_ac": "A0AAA9T6P6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9T6P6-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAMPIKENNKGNQICVDRGIMLQRNVTLEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 386, "header": "tr|A0AAA9T6P6-1|A0AAA9T6P6_BOVIN Isoform 1 of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099111.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099111.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092420.1" } ] } }, { "isoform_ac": "A0AAA9T7D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9T7D7-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNP", "length": 385, "header": "tr|A0AAA9T7D7-1|A0AAA9T7D7_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28732630, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095922.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095922.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092667.1" } ] } }, { "isoform_ac": "A0AAA9TJ27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#A0AAA9TJ27-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNESVGQ", "length": 359, "header": "tr|A0AAA9TJ27-1|A0AAA9TJ27_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=1 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28729365, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119070.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119070.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098331.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098331.1" } ] } }, { "isoform_ac": "F1MF38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6/entry#F1MF38-1", "sequence": { "sequence": "MRALQGLRGPRAPSLPLLLLCFLAALRRSLEHGLSTAAPFKSLPVQEEMMTKYSNLSLESHNISVTAAPFTSLPVQEEMMTKSSNLSLESHSISMTAAPFTSLPVQEEMMTKSSNLSLESHSISMTEHSNMPVEKNITLERPSNVELICQFTPSGDLNSVNVTWKKGDKLLEGNYLVNATGGILYTQHRVAVINSKQMGSYSCFFGEKKQQRGTFNLKVPEINGQNKPLITYLGDSVVLMCKCQDCLPLNWTWYGGNGSVQVPIGVPVNDKYVISGKHANETRLKITQLSEDDQGTYLCHAIFELGESEGHVKLVVLSYLVPLKVFCAIAAEVVLLVAAILLFEMYTQKKKKPSDDGKEFEQGEQLKLDDSNGIENSGPRHRKNEMRSTSLITTFPP", "length": 397, "header": "tr|F1MF38-1|F1MF38_BOVIN Computationally mapped isoform of Embigin OS=Bos taurus OX=9913 GN=EMB PE=4 SV=4 CANONICAL=A0AAA9T6P6-1" }, "locus": { "chromosome": "20", "start_pos": 28770472, "end_pos": 28670117, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061571.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061571.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053825.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053825.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-433692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-433692", "resource": "Reactome", "description": "Proton-coupled monocarboxylate transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" }, { "name": "dendrite self-avoidance", "id": "GO:0070593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cell-cell adhesion mediator activity", "id": "GO:0098632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6P6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P6" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 129, "end_pos": 200, "start_aa": "Pro", "end_aa": "Cys", 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "520912", "url": "https://www.ncbi.nlm.nih.gov/gene/520912", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520912", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520912", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VANHVAW", "url": "https://omabrowser.org/oma/group/VANHVAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10983:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10983:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01553", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01553", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQH3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHKTHLTSHSRMSGSRIMVSWRGIYFILTLFWGSFFGSIFMLGPFLPLMFISPSWYRWINNRIVATWLTLPVALLETMLGVKVVITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLQKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIREPLQLLLFPEGTDLTENSMTRSNEFAEKNGLQKYKYVLHPRTTGFTFVVDRLRKGKNLDAVHDITVAYPHNIPQTEKHLLLGDFPKEIHFHVHRYPVNTLPKSKEDLQLWCHKRWEEKEERLRSFYQGEKNFSFTGQTVVPPCKSELRVMVVKFLSILYWTLFSPTMCLFIYLYSLVRWYFIIIIVIFVLQERIFGGLEILELACYRLLHKQPHLNAKKNE", "length": 394, "header": "tr|A0AAA9T5S7-1|A0AAA9T5S7_BOVIN Isoform 1 of Lysocardiolipin acyltransferase 1 OS=Bos taurus OX=9913 GN=LCLAT1 PE=3 SV=1 CANONICAL=A0AAA9T5S7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7/entry#A0AAA9SQH3-1", "sequence": { "sequence": "MVSWRGIYFILTLFWGSFFGSIFMLGPFLPLMFISPSWYRWINNRIVATWLTLPVALLETMLGVKVVITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLQKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIREPLQLLLFPEGTDLTENSMTRSNEFAEKNGLQKYKYVLHPRTTGFTFVVDRLRKGKNLDAVHDITVAYPHNIPQTEKHLLLGDFPKEIHFHVHRYPVNTLPKSKEDLQLWCHKRWEEKEERLRSFYQGEKNFSFTGQTVVPPCKSELRVMVVKFLSILYWTLFSPTMCLFIYLYSLVRWYFIIIIVIFVLQERIFGGLEILELACYRLLHKQPHLNAKKNE", "length": 376, "header": "tr|A0AAA9SQH3-1|A0AAA9T5S7_BOVIN Computationally mapped isoform of Lysocardiolipin acyltransferase 1 OS=Bos taurus OX=9913 GN=LCLAT1 PE=3 SV=1 CANONICAL=A0AAA9T5S7-1" }, "locus": { "chromosome": "11", "start_pos": 69343372, "end_pos": 69226136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107849.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107849.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085195.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085195.1" } ] } }, { "isoform_ac": "A0AAA9T5S7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7/entry#A0AAA9T5S7-1", "sequence": { "sequence": "MLHKTHLTSHSRMSGSRIMVSWRGIYFILTLFWGSFFGSIFMLGPFLPLMFISPSWYRWINNRIVATWLTLPVALLETMLGVKVVITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLQKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIREPLQLLLFPEGTDLTENSMTRSNEFAEKNGLQKYKYVLHPRTTGFTFVVDRLRKGKNLDAVHDITVAYPHNIPQTEKHLLLGDFPKEIHFHVHRYPVNTLPKSKEDLQLWCHKRWEEKEERLRSFYQGEKNFSFTGQTVVPPCKSELRVMVVKFLSILYWTLFSPTMCLFIYLYSLVRWYFIIIIVIFVLQERIFGGLEILELACYRLLHKQPHLNAKKNE", "length": 394, "header": "tr|A0AAA9T5S7-1|A0AAA9T5S7_BOVIN Isoform 1 of Lysocardiolipin acyltransferase 1 OS=Bos taurus OX=9913 GN=LCLAT1 PE=3 SV=1 CANONICAL=A0AAA9T5S7-1" }, "locus": { "chromosome": "11", "start_pos": 69401576, "end_pos": 69226136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121448.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121448.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091109.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091109.1" } ] } }, { "isoform_ac": "A0AAA9TIQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7/entry#A0AAA9TIQ9-1", "sequence": { "sequence": "MAGWHHRLDGHEFGIMVSWRGIYFILTLFWGSFFGSIFMLGPFLPLMFISPSWYRWINNRIVATWLTLPVALLETMLGVKVVITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLQKICLKASLKSVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIREPLQLLLFPEGTDLTENSMTRSNEFAEKNGLQKYKYVLHPRTTGFTFVVDRLRKGKNLDAVHDITVAYPHNIPQTEKHLLLGDFPKEIHFHVHRYPVNTLPKSKEDLQLWCHKRWEEKEERLRSFYQGEKNFSFTGQTVVPPCKSELRVMVVKFLSILYWTLFSPTMCLFIYLYSLVRWYFIIIIVIFVLQERIFGGLEILELACYRLLHKQPHLNAKKNE", "length": 391, "header": "tr|A0AAA9TIQ9-1|A0AAA9TIQ9_BOVIN Computationally mapped isoform of Lysocardiolipin acyltransferase 1 OS=Bos taurus OX=9913 GN=LCLAT1 PE=3 SV=1 CANONICAL=A0AAA9T5S7-1" }, "locus": { "chromosome": "11", "start_pos": 69356517, "end_pos": 69226136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094231.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094231.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098346.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098346.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520912", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520912", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z2S4-1", "protein_name": "LBH regulator of WNT signaling pathway", "gene_name": "LCLAT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESAPLGKAFESSPWPGLISDFISSLHRYQGTYSTDEVMMNNRHFQKKVSLFLLCKRQKEPSVQSHNDGVRWEVSGPLLVQRIQCCPTPTDRLALEGLEAPARLPCFWGKGLAAARQILQCEFPSFRPGCCSRGQHTAELAMVSWKGIYFVVALFLGSFFGSIFMLGPFLPLMFISPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNNLDAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCISLLYWTVFPMGTFALLYLYSFARWYFAAMIIIFVAQQKIFGGLELIELACHQYFKKQQKHDDTKMKKK", "length": 519 }, "evidence": [ { "id": "A0AAA9T5S7", "url": "https://omabrowser.org/oma/group/A0AAA9T5S7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZFF4-1", "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "Lclat1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSWKGIYFILFLFAGSFFGSIFMLGPILPLMFINLSWYRWISSRLVAMWLTLPVALLETMFGVKVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRLEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMVDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLRERRNLDAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVHRYPVDTLPTSKEDLQLWCHKRWEEKEERLRSFYQGEKNFHFTGQSTVPPCKSELRVLVVKLLSILYWALFCSAMCLLIYLYSPVRWYFIISIVFFVLQERIFGGLEIIELACYRFLHKHPHLNSKKNE", "length": 376 }, "evidence": [ { "id": "A0AAA9T5S7", "url": "https://omabrowser.org/oma/group/A0AAA9T5S7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UN02-1", "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "Lclat1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSWKGIYFILFLFAGSFFGSIFMLGPILPLMFINLSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQGEKNFHFTGQSTVPPCKSELRVLVVKLLSIVYWALFCSAMCLLIYLYSPVRWYFIISIVFFVLQERIFGGLEIIELACYRFLHKHPHLNSKKNE", "length": 376 }, "evidence": [ { "id": "A0AAA9T5S7", "url": "https://omabrowser.org/oma/group/A0AAA9T5S7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6NYV8-1", "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "lclat1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVSPRGVCFLLFLLLGSVFGSVFMLGPLLPLMLLSPSRYRWITDRIVATWLTLPVALLELVLGVKVVVTGDGFIPGERSVIIMNHRTRLDWMFLWCCLLRYSYLRQEKICLKAALKSVPGFGWAMQVASFIFIQRRWEDDRTHMSNMLQYFCRIREPVQLLLFPEGTDLTENTRARSDEFAEKNGLQKYEYVLHPRTTGFTFIVDTLRGGDNLDAVHDITVAYPQNIPQTERHLLAGVFPREIHFHVQRFTVASVPAGAAGLQAWCQERWREKERRLQRFYETVPRRFDAPAVGVCVREPCCQSGQCVCVPRCKSEGRVRIILVASLLYWSVFITAACASLCLCPPAQFYFLFMVVFFLCQQRFTGGLELMELACHRYWSRRSADKQE", "length": 388 }, "evidence": [ { "id": "A0AAA9T5S7", "url": "https://omabrowser.org/oma/group/A0AAA9T5S7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6UWP7-1", "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "LCLAT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSIFMLSPFLPLMFVNPSWYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKLLSILYWTLFSPAMCLLIYLYSLVKWYFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE", "length": 414 }, "evidence": [ { "id": "A0AAA9T5S7", "url": "https://omabrowser.org/oma/group/A0AAA9T5S7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7" } ], "pmid": "" }, { "name": "1-acylglycerol-3-phosphate O-acyltransferase activity", "id": "GO:0003841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003841", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5S7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5S7" }, { "id": "SM00563", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phospholipid/glycerol acyltransferase", "eco_id": "ECO_0000259", "start_pos": 97, "end_pos": 219, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 304, "end_pos": 306 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5M6-1", "uniprot_ac": "A0AAA9T5M6", "uniprot_id": "A0AAA9T5M6_BOVIN", "mass": { "chemical_mass": 56756.0, "monoisotopic_mass": 56756.0 }, "refseq": {}, "gene_names": [ { "name": "ACD", "type": "recommended", "evidence": [ { "id": "A0AAA9T5M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ] } ], "protein_names": [ { "name": "ACD shelterin complex subunit and telomerase recruitment factor", "type": "synonym", "evidence": [ { "id": "A0AAA9T5M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY73#function" }, { "database": "UniProtKB", "id": "ARBA00053730", "url": "https://www.uniprot.org/uniprotkb/ARBA00053730#function" }, { "database": "UniProtKB", "id": "A0AAA9SX91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX91#function" }, { "database": "UniProtKB", "id": "A0AAA9SR89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR89#function" }, { "database": "UniProtKB", "id": "A0AAA9SRP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP1#function" }, { "database": "UniProtKB", "id": "A0AAA9SV65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV65#function" }, { "database": "UniProtKB", "id": "F6RPJ3", "url": "https://www.uniprot.org/uniprotkb/F6RPJ3#function" }, { "database": "UniProtKB", "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACD", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6", "locus": { "chromosome": "18", "start_pos": 35204681, "end_pos": 35214286, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018903", "url": "https://www.ensembl.org/id/ENSBTAG00000018903" } ] } } ], "crossref": [ { "id": "A0AAA9T5M6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018903", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018903", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510353", "url": "https://www.ncbi.nlm.nih.gov/gene/510353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510353", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510353", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FDCLEEH", "url": "https://omabrowser.org/oma/group/FDCLEEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY73", "url": "https://www.orthodb.org/?gene=A0A3Q1LY73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6RPJ3", "url": "https://www.orthodb.org/?gene=F6RPJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14487", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14487", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14487:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14487:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10341", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10341", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110330", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110330", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110331", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110331", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171306", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171306", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171319", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174414", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174414", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174417", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174417", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174437", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174437", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559586", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9670095", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9670095", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LY73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RPJ3", "url": "https://www.uniprot.org/uniprotkb/F6RPJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RPJ3-1", "url": "https://www.uniprot.org/uniprotkb/F6RPJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAASGRLWATPGPGSCSDPLELLLRAPPLSSGRAEMLVSHTPLTCTWPWTYTAHTHSHPTEYPKHPKPPGHQQTKTQVSPGSHVPTCHPLCSKQSLQYPPPPP", "length": 529, "header": "tr|A0AAA9T5M6-1|A0AAA9T5M6_BOVIN Isoform 1 of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0A3Q1LY73-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGWEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAARLPPQLVAWALHFLMEPQPDSELTQM", "length": 440, "header": "tr|A0A3Q1LY73-1|A0A3Q1LY73_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=2 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35208082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060581.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060581.2" } ] } }, { "isoform_ac": "A0AAA9SR89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0AAA9SR89-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATDPPERHRDGSAFQYEYRPPCPSLCAQVQAARLPPQLVAWALHFLMEPQPDSELTQM", "length": 269, "header": "tr|A0AAA9SR89-1|A0AAA9T5M6_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35208082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105000.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105000.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086579.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086579.1" } ] } }, { "isoform_ac": "A0AAA9SRP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0AAA9SRP1-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAARLPPQLVAWALHFLMEPQPDSELTQM", "length": 426, "header": "tr|A0AAA9SRP1-1|A0AAA9T5M6_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35208082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111261.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111261.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086631.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086631.1" } ] } }, { "isoform_ac": "A0AAA9SV65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0AAA9SV65-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAARLPPQLVAWALHFLMEPQPDSELTQM", "length": 397, "header": "tr|A0AAA9SV65-1|A0AAA9T5M6_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35208082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101210.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101210.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090359.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090359.1" } ] } }, { "isoform_ac": "A0AAA9SX91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0AAA9SX91-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAARFLLDLQRMGLSPLQGGDTGGLGQSGNQEGRKGESDRPVRSLLVT", "length": 474, "header": "tr|A0AAA9SX91-1|A0AAA9T5M6_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35205870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093948.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093948.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088834.1" } ] } }, { "isoform_ac": "A0AAA9T5M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#A0AAA9T5M6-1", "sequence": { "sequence": "MASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAASGRLWATPGPGSCSDPLELLLRAPPLSSGRAEMLVSHTPLTCTWPWTYTAHTHSHPTEYPKHPKPPGHQQTKTQVSPGSHVPTCHPLCSKQSLQYPPPPP", "length": 529, "header": "tr|A0AAA9T5M6-1|A0AAA9T5M6_BOVIN Isoform 1 of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35213750, "end_pos": 35204681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091046.1" } ] } }, { "isoform_ac": "F6RPJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6/entry#F6RPJ3-1", "sequence": { "sequence": "MLGTSLRFQSSPSPSEPVLGPFLPSATGDLKNGPNALPLLGEMLGGEAGPRRTGKTRARGYLRSPAAGMASFGGLVLRPWIRELVLGSDALSSPRAGQLLKVLQEAKAQSPSGAPDPPDAEAMLLVSDGTHSIRCLVTGEALNASDWEEKEFGFRGTEGRILLLRDCKVSVQVAQGDTPAEFYLQVDRFALLPTEQPREQVTGCNEDPDVRKKLCDCLEEHLSESTSSNTGLSLSQLLNEVEVDQEHQKALVRLAESCLILAGPDTAAPITPWAASRCRATGEAVYTVPSLRLHISENDQQILSSLGPTQRVQGPERSPSHLALQDLSLSLISSPPSSPSSSGTPAIPSHLLSKENSASVSLLPPLPLAAPDPVQKGSSQPLSTICSAHGSLPPGSPHPSSIPNTPLLSCTPSLSRLGHAPSIHQAHVSRAQKPSLEFKELGLPPKTLHHSPRTRTTKGALESSCVWDPPERHRDGSAFQYEYRPPCPSLCAQVQAARLPPQLVAWALHFLMEPQPDSELTQM", "length": 523, "header": "tr|F6RPJ3-1|F6RPJ3_BOVIN Computationally mapped isoform of ACD shelterin complex subunit and telomerase recruitment factor OS=Bos taurus OX=9913 GN=ACD PE=4 SV=1 CANONICAL=A0AAA9T5M6-1" }, "locus": { "chromosome": "18", "start_pos": 35214087, "end_pos": 35208082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025159.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025159.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025159.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025159.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 276, "start_aa": "Thr", "end_pos": 276, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr276", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510353", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510353", "resource": "KEGG Pathway" }, { "id": "R-BTA-110330", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110330", "resource": "Reactome", "description": "Recognition and association of DNA glycosylase with site containing an affected purine" }, { "id": "R-BTA-110331", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110331", "resource": "Reactome", "description": "Cleavage of the damaged purine" }, { "id": "R-BTA-171306", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171306", "resource": "Reactome", "description": "Packaging Of Telomere Ends" }, { "id": "R-BTA-171319", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "resource": "Reactome", "description": "Telomere Extension By Telomerase" }, { "id": "R-BTA-174411", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "resource": "Reactome", 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"https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ], "pmid": "" }, { "name": "protein localization to chromosome, telomeric region", "id": "GO:0070198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ], "pmid": "" }, { "name": "establishment of protein localization to telomere", "id": "GO:0070200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ], "pmid": "" }, { "name": "regulation of establishment of protein localization to telomere", "id": "GO:0070203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "telomeric DNA binding", 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"categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024851931", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851931", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SX90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2A5", "url": "https://www.uniprot.org/uniprotkb/F1N2A5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2A5-1", "url": "https://www.uniprot.org/uniprotkb/F1N2A5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLPVVLPGSCCPVAGLSGGPQAGGPGAAAAAAQEPPLPPLRPRWPRAALQPPARPRCGATGVLAAPPALSSRRAAAAAGAPGSALLPARLLLSLGLLQLILGCCMVALSFGALSLSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPMILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEELQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAALRYLQIFAARRSCVDESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQADQQQGSSFQMPEGPEVATSPLEPICMPGIQGGDIPATPGEESASIPTPNTNQLCPARSWRALRPLRTRSKSDPVLHHSAERAVPVLSCEAATQTEGRLDLAAVTLRRRLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPMQPSTARALVLPSRKQPGLLHLRSCGDLSTFVPAGRPLAERRPRRAEAERPHSLIGVIRETVL", "length": 598, "header": "tr|A0AAA9T7L5-1|A0AAA9T7L5_BOVIN Isoform 1 of Endosomal transmembrane epsin interactor 1 OS=Bos taurus OX=9913 GN=ENTREP1 PE=3 SV=2 CANONICAL=A0AAA9T7L5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SX90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5/entry#A0AAA9SX90-1", "sequence": { "sequence": "MSLPVVLPGSCCPVAGLSGGPQAGGPGAAAAAAQEPPLPPLRPRWPRAALQPPARPRCGATGVLAAPPALSSRRAAAAAGAPGSALLPARLLLSLGLLQLILGCCMVALSFGALSLSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPMILLVDLGEGKICFCCEELQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAALRYLQIFAARRSCVDESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQADQQQGSSFQMPEGPEVATSPLEPICMPGIQGGDIPATPGEESASIPTPNTNQLCPARSWRALRPLRTRSKSDPVLHHSAERAVPVLSCEAATQTEGRLDLAAVTLRRRLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPMQPSTARALVLPSRKQPGLLHLRSCGDLSTFVPAGRPLAERRPRRAEAERPHSLIGVIRETVL", "length": 561, "header": "tr|A0AAA9SX90-1|A0AAA9T7L5_BOVIN Computationally mapped isoform of Endosomal transmembrane epsin interactor 1 OS=Bos taurus OX=9913 GN=ENTREP1 PE=3 SV=1 CANONICAL=A0AAA9T7L5-1" }, "locus": { "chromosome": "8", "start_pos": 45531798, "end_pos": 45455792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131384.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131384.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089959.1" } ] } }, { "isoform_ac": "A0AAA9T7L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5/entry#A0AAA9T7L5-1", "sequence": { "sequence": "MSLPVVLPGSCCPVAGLSGGPQAGGPGAAAAAAQEPPLPPLRPRWPRAALQPPARPRCGATGVLAAPPALSSRRAAAAAGAPGSALLPARLLLSLGLLQLILGCCMVALSFGALSLSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPMILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEELQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAALRYLQIFAARRSCVDESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQADQQQGSSFQMPEGPEVATSPLEPICMPGIQGGDIPATPGEESASIPTPNTNQLCPARSWRALRPLRTRSKSDPVLHHSAERAVPVLSCEAATQTEGRLDLAAVTLRRRLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPMQPSTARALVLPSRKQPGLLHLRSCGDLSTFVPAGRPLAERRPRRAEAERPHSLIGVIRETVL", "length": 598, "header": "tr|A0AAA9T7L5-1|A0AAA9T7L5_BOVIN Isoform 1 of Endosomal transmembrane epsin interactor 1 OS=Bos taurus OX=9913 GN=ENTREP1 PE=3 SV=2 CANONICAL=A0AAA9T7L5-1" }, "locus": { "chromosome": "8", "start_pos": 45531798, "end_pos": 45455792, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115065.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115065.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092590.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092590.2" } ] } }, { "isoform_ac": "F1N2A5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5/entry#F1N2A5-1", "sequence": { "sequence": "MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEELQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAALRYLQIFAARRSCVDESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQADQQQGSSFQMPEGPEVATSPLEPICMPGIQGGDIPATPGEESASIPTPNTNQLCPARSWRALRPLRTRSKSDPVLHHSAERAVPVLSCEAATQTEGRLDLAAVTLRRRLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPMQPSTARALVLPSRKQPGLLHLRSCGDLSTFVPAGRPLAERRPRRAEAERPHSLIGVIRETVL", "length": 450, "header": "tr|F1N2A5-1|A0AAA9T7L5_BOVIN Computationally mapped isoform of Endosomal transmembrane epsin interactor 1 OS=Bos taurus OX=9913 GN=ENTREP1 PE=3 SV=2 CANONICAL=A0AAA9T7L5-1" }, "locus": { "chromosome": "8", "start_pos": 45531798, "end_pos": 45469516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014839.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014839.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014839.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014839.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 389, "start_aa": "Thr", "end_pos": 389, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr389", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K3C3-1", "protein_name": "Endosomal transmembrane epsin interactor 1", "gene_name": "Entrep1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLPVVLPGSCCPVAGLSGGPQAGGPGAAAAAAQEPPLPPLRPRWPRGALQPPARPRCAPAAVLAPPPALASRRPAAPGSALLPARPLLSLGLLQLILGCCMVALSFGALSLSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPMILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFASRRPCIDESQISAEEVEEPGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQADQEQESSFQMPEGPETAASPVEPVCTQITRGGVLTNTPAEENTSGSTPLSNVVQPPRSRRALPLLRTRSKSDPMLHHSEERATPVLSCEAATQTERRLDLATVTLRRGARPRASRCRPHSLIDYRSYIDTKLLVARFLEQSSCSMTPDIHELVENIKSVLKSDEGHMEEAITSASFLEQIMAPAQPSTSQAQMLTSRRQPGLLHLRSCGDLSTFSLAGRPRAERRLQQRAEAERPHSLIGVIRETVL", "length": 595 }, "evidence": [ { "id": "A0AAA9T7L5", "url": "https://omabrowser.org/oma/group/A0AAA9T7L5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q15884-3", "protein_name": "Endosomal transmembrane epsin interactor 1", "gene_name": "ENTREP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFATRRSCIDESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQMDQEQGSSFQMSEGSEAAVIPLDLGCTQVTQDGDIPNIPAEENASTSTPSSTLVRPIRSRRALPPLRTRSKSDPVLHPSEERAAPVLSCEAATQTERRLDLAAVTLRRGLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPLQPSTSRAHKLPSRRQPGLLHLQSCGDLHTFTPAGRPRAERRPRRVEAERPHSLIGVIRETVL", "length": 450 }, "evidence": [ { "id": "A0AAA9T7L5", "url": "https://omabrowser.org/oma/group/A0AAA9T7L5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4FZH1-1", "protein_name": "Endosomal transmembrane epsin interactor 1", "gene_name": "Entrep1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFASRRPCIDESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQTDQEQESSFQMPEGPETAASPAEPVCTQITQGGALTNTTGEENTSGSTPILTLVQPPRSRRALPLLRTRSKSDPVLHHSEERATPVLSCEAATQTERRLDLATVTLRRGARPRASRCRPRSLIDYRSYIDTKLLVARFLEQSSCSMTPDIHELVENIKSVLKSDEGHMEEAITSASFLEQIMAPSQPSTSQAQELSWRRQPGLLHLRSCGDLSTFSLTARPRAERRPQQRAEAERPHSLIGVIRETVL", "length": 451 }, "evidence": [ { "id": "A0AAA9T7L5", "url": "https://omabrowser.org/oma/group/A0AAA9T7L5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "CXCL12-activated CXCR4 signaling pathway", "id": "GO:0038160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038160", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" }, { "name": "negative adaptation of signaling pathway", "id": "GO:0022401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022401", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin ligase activator activity", "id": "GO:1990757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990757", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 389 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVNSTEVSEFFLKGFSGYPALEHLLFPLCSAMYLVTLLGNTGIVAVSVLDARLHTPMYFFLGNLSILDICYTSTFVPLMLVHLLSAQKTISFLGCALQMCLGLSTGSTECLLLTIMAYDRYLAICRPLRYPVLMSHRLCWLLAGAAWVFCLFMSVTETVIAMRLPFCGHRVVSHFGCEILAVLKLACGDTSISEVFLLVGAILLLPVPLAFICLSYTLILATTLRVPSAAGRRKAFSTCSAHLAVVMLYYGTVIFMYMKPKSKEARISDEVFTVLYAVVTPMLNPVIYSLRNKEVKEAARKVWGRIQTSRQSPGPALSISLRYLTPASRLDSGFQSCSSQSILQGSSRGIFRKSLFDHVSLLAKTPEWLPELSG", "length": 376, "header": "tr|A0AAA9T8M1-1|A0AAA9T8M1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR13J1C PE=3 SV=1 CANONICAL=A0AAA9T8M1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T4G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1/entry#A0AAA9T4G9-1", "sequence": { "sequence": "MEPVNSTEVSEFFLKGFSGYPALEHLLFPLCSAMYLVTLLGNTGIVAVSVLDARLHTPMYFFLGNLSILDICYTSTFVPLMLVHLLSAQKTISFLGCALQMCLGLSTGSTECLLLTIMAYDRYLAICRPLRYPVLMSHRLCWLLAGAAWVFCLFMSVTETVIAMRLPFCGHRVVSHFGCEILAVLKLACGDTSISEVFLLVGAILLLPVPLAFICLSYTLILATTLRVPSAAGRRKAFSTCSAHLAVVMLYYGTVIFMYMKPKSKEARISDEVFTVLYAVVTPMLNPVIYSLRNKEVKEAARKVWGRIQTSR", "length": 312, "header": "tr|A0AAA9T4G9-1|A0AAA9T8M1_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR13J1C PE=3 SV=1 CANONICAL=A0AAA9T8M1-1" }, "locus": { "chromosome": "8", "start_pos": 60082226, "end_pos": 60081291, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093672.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093672.1" } ] } }, { "isoform_ac": "A0AAA9T8M1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1/entry#A0AAA9T8M1-1", "sequence": { "sequence": "MEPVNSTEVSEFFLKGFSGYPALEHLLFPLCSAMYLVTLLGNTGIVAVSVLDARLHTPMYFFLGNLSILDICYTSTFVPLMLVHLLSAQKTISFLGCALQMCLGLSTGSTECLLLTIMAYDRYLAICRPLRYPVLMSHRLCWLLAGAAWVFCLFMSVTETVIAMRLPFCGHRVVSHFGCEILAVLKLACGDTSISEVFLLVGAILLLPVPLAFICLSYTLILATTLRVPSAAGRRKAFSTCSAHLAVVMLYYGTVIFMYMKPKSKEARISDEVFTVLYAVVTPMLNPVIYSLRNKEVKEAARKVWGRIQTSRQSPGPALSISLRYLTPASRLDSGFQSCSSQSILQGSSRGIFRKSLFDHVSLLAKTPEWLPELSG", "length": 376, "header": "tr|A0AAA9T8M1-1|A0AAA9T8M1_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR13J1C PE=3 SV=1 CANONICAL=A0AAA9T8M1-1" }, "locus": { "chromosome": "8", "start_pos": 60082226, "end_pos": 60080923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094310.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094310.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615852", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615852", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8C9-1", "uniprot_ac": "A0AAA9T8C9", "uniprot_id": "A0AAA9T8C9_BOVIN", "mass": { "chemical_mass": 50002.0, "monoisotopic_mass": 50002.0 }, "refseq": {}, "gene_names": [ { "name": "MEIKIN", "type": "recommended", "evidence": [ { "id": "A0AAA9T8C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9" } ] } ], "protein_names": [ { "name": "Meiotic kinetochore factor", "type": "synonym", "evidence": [ { "id": "A0AAA9T8C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEIKIN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9", "locus": { "chromosome": "7", "start_pos": 22684095, "end_pos": 22547788, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000058820", "url": "https://www.ensembl.org/id/ENSBTAG00000058820" } ] } } ], "crossref": [ { "id": "A0AAA9T8C9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8C9", "database": "AlphaFoldDB", "categories": [] }, { "id": "101907984", "url": "https://www.ncbi.nlm.nih.gov/gene/101907984", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR034545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101907984", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907984", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR38006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38006:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38006:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27928", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27928", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T524", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T524", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T524-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T524-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSLGVYTRKKQARGRLNLTPTTGLGARAKAEAPSRSGRKLFAHCLKRNGKTRGLQRIAEKSERSGQGGDSSRPPSTELKATGEKNLHENSTSEETQDEKIALLSESVTDDLQADSSNSSNSKQVTGLSLQHDISGSLLSYSFTDSSTEYKSSEENLSSFPSPELFRGSDYLEWEHPMLEENMPCKNSTLLDISKAVAIEKVPEFSNLSAILGTSSEDYQKCHRKVMTMLADQNISSELKAESDNASCGVLLAEKNCPSTPGEKKEKPEKDPEPRDTNFQTTLSSRRLKSKVPSSHQRSVVESSAGKSVAKVLLPQPLKPALNAHSSTSDKKSRGLLTSTPSSQTPGLVIDLSSVQKASFEELFPNVSNYVNSDEIVPVSTLQDSSSNEVPSNASEICYIIKASPGTRQVESKGIIVKKKYSLPKDIPQVFPSIRVFSNAIALCIMGQSVGASASASVLPIL", "length": 462, "header": "tr|A0AAA9T8C9-1|A0AAA9T8C9_BOVIN Isoform 1 of Meiotic kinetochore factor OS=Bos taurus OX=9913 GN=MEIKIN PE=4 SV=1 CANONICAL=A0AAA9T8C9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T524-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9/entry#A0AAA9T524-1", "sequence": { "sequence": "MWSLGVYTRKKQARGRLNLTPTTGLGARAKAEAPSRSGRKLFAHCLKRNGKTRGLQRIAEKSERSGQGGDSSRPPSTELKATGEKNLHENSTSEETQDEKIALLSESVTDDLQADSSNSSNSKQVTGLSLQHDISGSLLSYSFTDSSTEYKSSEENLSSFPSPELFRGSDYLEWEHPMLEENMPCKNSTLLDISKAVAIEKVPEFSNLSAILGTSSEDYQKCHRKVMTMLADQNISSELKAESDNASCGVLLAEKNCPSTPGEKKEKPEKDPEPRDTNFQTTLSSRRLKSKVPSSHQRSVVESSAGKSVAKVLLPQPLKPALNAHSSTSDKKSRGLLTSTPSSQTPGLVVPSNASEICYIIKASPGTRQVESKGIIVKKKYSLPKDIPQDIIIKTSGRM", "length": 399, "header": "tr|A0AAA9T524-1|A0AAA9T8C9_BOVIN Computationally mapped isoform of Meiotic kinetochore factor OS=Bos taurus OX=9913 GN=MEIKIN PE=4 SV=1 CANONICAL=A0AAA9T8C9-1" }, "locus": { "chromosome": "7", "start_pos": 22683698, "end_pos": 22548026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134610.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134610.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091817.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091817.1" } ] } }, { "isoform_ac": "A0AAA9T8C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9/entry#A0AAA9T8C9-1", "sequence": { "sequence": "MWSLGVYTRKKQARGRLNLTPTTGLGARAKAEAPSRSGRKLFAHCLKRNGKTRGLQRIAEKSERSGQGGDSSRPPSTELKATGEKNLHENSTSEETQDEKIALLSESVTDDLQADSSNSSNSKQVTGLSLQHDISGSLLSYSFTDSSTEYKSSEENLSSFPSPELFRGSDYLEWEHPMLEENMPCKNSTLLDISKAVAIEKVPEFSNLSAILGTSSEDYQKCHRKVMTMLADQNISSELKAESDNASCGVLLAEKNCPSTPGEKKEKPEKDPEPRDTNFQTTLSSRRLKSKVPSSHQRSVVESSAGKSVAKVLLPQPLKPALNAHSSTSDKKSRGLLTSTPSSQTPGLVIDLSSVQKASFEELFPNVSNYVNSDEIVPVSTLQDSSSNEVPSNASEICYIIKASPGTRQVESKGIIVKKKYSLPKDIPQVFPSIRVFSNAIALCIMGQSVGASASASVLPIL", "length": 462, "header": "tr|A0AAA9T8C9-1|A0AAA9T8C9_BOVIN Isoform 1 of Meiotic kinetochore factor OS=Bos taurus OX=9913 GN=MEIKIN PE=4 SV=1 CANONICAL=A0AAA9T8C9-1" }, "locus": { "chromosome": "7", "start_pos": 22683675, "end_pos": 22548026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095374.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095374.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094215.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094215.1" } ] } }, { "isoform_ac": "A0AAA9TIJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8C9/entry#A0AAA9TIJ7-1", "sequence": { "sequence": "MWSLGVYTRKKQARGRLNLTPTTGLGARAKAEAPSRSGRKLFAHCLKRNGKTRGLQRIAEKSERSGQGGDSSRPPSTELKATGEKNLHENSTSEETQDEKIALLSESVTDDLQADSSNSSNSKQVTGLSLQHDISGSLLSYSFTDSSTEYKSSEENLSSFPSPELFRGSDYLEWEHPMLEENMPCKNSTLLDISKAVAIEKVPEFSNLSAILGTSSEDYQKCHRKVMTMLADQNISSELKAESDNASCGVLLAEKNCPSTPGEKKEKPEKDPEPRDTNFQTTLSSRRLKSKVPSSHQRSVVESSAGKSVAKVLLPQPLKPALNAHSSTSDKKSRGLLTSTPSSQTPGLVIDLSSVQKASFEELFPNVSNYVNSDEIVPVSTLQDSSSNEVPSNASEICYIIKASPGTRQVESKGIIVKKKYSLPKDIPQDIIIKTSGRM", "length": 439, "header": "tr|A0AAA9TIJ7-1|A0AAA9TIJ7_BOVIN Computationally mapped isoform of Meiotic kinetochore factor OS=Bos taurus OX=9913 GN=MEIKIN PE=4 SV=1 CANONICAL=A0AAA9T8C9-1" }, "locus": { "chromosome": "7", "start_pos": 22683698, "end_pos": 22548026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096732.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 260, "start_aa": "Thr", "end_pos": 260, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr260", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:101907984", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101907984", "resource": "KEGG Pathway" } ], 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF12316", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201688", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201688", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2028269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2028269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086400", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086400", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5099900", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5099900", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MSZ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T567", "url": 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"MKVAWSSLPQQIKWAGIACLPPEGRAQAGQSSRRTRVGTHMEEEPQKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPAHEPRTDLAPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSRENLEPETETESVVSLRRERPRRRDSTGGHRPSGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERASSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSIHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEDRAPESKSGSGSESEPSSRGGSLRRGGEPGGTGDGGPPPSRGSSGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPKPPPWHRGQWHCPPDAAAETVHLPAWPPPRWQTAPEPAPPEEMGWCLG", "length": 789, "header": "tr|A0AAA9T567-1|A0AAA9T567_BOVIN Isoform 1 of Dishevelled segment polarity protein 2 OS=Bos taurus OX=9913 GN=DVL2 PE=3 SV=1 CANONICAL=A0AAA9T567-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MSZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T567/entry#A0A3Q1MSZ4-1", "sequence": { "sequence": "MKVAWSSLPQQIKWAGIACLPPEGRAQAGQSSRRTRVGTHMEEEPQKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPAHEPRTDLAPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSRENLEPETETESVVSLRRERPRRRDSTGGHRPSGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERASSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSIHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEDRAPESKSGSGSESEPSSRGGSLRRGGEPGGTGDGGPPPSRGSSGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM", "length": 749, "header": "tr|A0A3Q1MSZ4-1|A0A3Q1MSZ4_BOVIN Computationally mapped isoform of Dishevelled segment polarity protein 2 OS=Bos taurus OX=9913 GN=DVL2 PE=3 SV=2 CANONICAL=A0AAA9T567-1" }, "locus": { "chromosome": "19", "start_pos": 26948608, "end_pos": 26940693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078307.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078307.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057707.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057707.2" } ] } }, { "isoform_ac": "A0AAA9T567-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T567/entry#A0AAA9T567-1", "sequence": { "sequence": "MKVAWSSLPQQIKWAGIACLPPEGRAQAGQSSRRTRVGTHMEEEPQKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPAHEPRTDLAPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSRENLEPETETESVVSLRRERPRRRDSTGGHRPSGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERASSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSIHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEDRAPESKSGSGSESEPSSRGGSLRRGGEPGGTGDGGPPPSRGSSGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPKPPPWHRGQWHCPPDAAAETVHLPAWPPPRWQTAPEPAPPEEMGWCLG", "length": 789, "header": "tr|A0AAA9T567-1|A0AAA9T567_BOVIN Isoform 1 of Dishevelled segment polarity protein 2 OS=Bos taurus OX=9913 GN=DVL2 PE=3 SV=1 CANONICAL=A0AAA9T567-1" }, "locus": { "chromosome": 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Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG60#function" }, { "database": "UniProtKB", "id": "ARBA00054598", "url": "https://www.uniprot.org/uniprotkb/ARBA00054598#function" }, { "database": "UniProtKB", "id": "A0AAA9T571", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T571", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571", "locus": { "chromosome": "19", "start_pos": 47864567, "end_pos": 47841721, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016613", "url": "https://www.ensembl.org/id/ENSBTAG00000016613" } ] } } ], "crossref": [ { "id": "A0AAA9T571", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T571", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016613", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016613", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527872", "url": "https://www.ncbi.nlm.nih.gov/gene/527872", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527872", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527872", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWEDRRP", "url": "https://omabrowser.org/oma/group/FWEDRRP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BMA2", "url": "https://www.orthodb.org/?gene=E1BMA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217:SF468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005220945", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220945", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T571", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T571-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMA2", "url": "https://www.uniprot.org/uniprotkb/E1BMA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BMA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BMA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPRSAMSRLAQALLGAEECKVDILYYRKDASCFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKRGSRSLSQRLLRQSFLGSDGSHGRSGAQGPGAGRVKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTLLHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGDCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFADSFWSKLEVTFNLRDAGGGLQSSPQQAPGSQDHQQGFFLSDNQSGAAPSLSISDASGLWPELLQQVPPRPNQSPQNPQGDSDCWPRELGSRLEQLQAQMNRLESRMSSDLSRILKLLQQPLPQDHTGYILGASTSNDLALFPATSATQSPGTRLPRGDPPPAQMPSYGDMDEWRPELRNSSSRMPPSAVEMDRTLTLSSEQKQPEGLLSPLASPLCPLEVQGLVCGPRYPSLPEHLSSVPKQLEFQRHGSDPGFSRS", "length": 958, "header": "tr|A0AAA9T571-1|A0AAA9T571_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH6 PE=3 SV=1 CANONICAL=A0AAA9T571-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T571-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571/entry#A0AAA9T571-1", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPRSAMSRLAQALLGAEECKVDILYYRKDASCFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKRGSRSLSQRLLRQSFLGSDGSHGRSGAQGPGAGRVKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTLLHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGDCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFADSFWSKLEVTFNLRDAGGGLQSSPQQAPGSQDHQQGFFLSDNQSGAAPSLSISDASGLWPELLQQVPPRPNQSPQNPQGDSDCWPRELGSRLEQLQAQMNRLESRMSSDLSRILKLLQQPLPQDHTGYILGASTSNDLALFPATSATQSPGTRLPRGDPPPAQMPSYGDMDEWRPELRNSSSRMPPSAVEMDRTLTLSSEQKQPEGLLSPLASPLCPLEVQGLVCGPRYPSLPEHLSSVPKQLEFQRHGSDPGFSRS", "length": 958, "header": "tr|A0AAA9T571-1|A0AAA9T571_BOVIN Isoform 1 of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH6 PE=3 SV=1 CANONICAL=A0AAA9T571-1" }, "locus": { "chromosome": "19", "start_pos": 47864238, "end_pos": 47841787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090377.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090377.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092971.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092971.1" } ] } }, { "isoform_ac": "A0AAA9TG60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571/entry#A0AAA9TG60-1", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPRSAMSRLAQALLGAEECKVDILYYRKDASCFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKRGSRSLSQRLLRQSFLGSDGSHGRSGAQGPGAGRVKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTLLHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGDCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFADSFWSKLEVTFNLRDYEDSYQLRSTNYVAGGGLQSSPQQAPGSQDHQQGFFLSDNQSGAAPSLSISDASGLWPELLQQVPPRPNQSPQNPQGDSDCWPRELGSRLEQLQAQMNRLESRMSSDLSRILKLLQQPLPQDHTGYILGASTSNDLALFPATSATQSPGTRLPRGDPPPAQMPSYGDMDEWRPELRNSSSRMPPSAVEMDRTLTLSSEQKQPEGLLSPLASPLCPLEVQGLVCGPRYPSLPEHLSSVPKQLEFQRHGSDPGFSRS", "length": 971, "header": "tr|A0AAA9TG60-1|A0AAA9TG60_BOVIN Computationally mapped isoform of Voltage-gated inwardly rectifying potassium channel KCNH2 OS=Bos taurus OX=9913 GN=KCNH6 PE=3 SV=1 CANONICAL=A0AAA9T571-1" }, "locus": { "chromosome": "19", "start_pos": 47864238, "end_pos": 47841787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096020.1" } ] } }, { "isoform_ac": "E1BMA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571/entry#E1BMA2-1", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPRSAMSRLAQALLGAEECKVDILYYRKDASCFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKRGSRSLSQRLLRQSFLGSDGSHGRSGAQGPGAGRVKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTLLHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGDCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFADSFWSKLEVTFNLRDAGGGLQSSPQQAPGSQDHQQGFFLSDNQSGAAPSLSISDASGLWPELLQQVPPRPNQSPQNPQGDSDCWPRELGSRLEQLQAQMNRLESRMSSDLSRILKLLQQPLPQDHTGYILGASTSNDLALFPATSATQSPGTRLPRGDPPPAQMPSYGDMDEWRPELRNSSSRMPPSAVEMDRTLTLSSEQKQPEGLLSPLASPLCPLEVQGLVCGPRYPSLPEHLSSVPKQLEFQRHGSDPGFSRS", "length": 905, "header": "tr|E1BMA2-1|E1BMA2_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily H member 6 OS=Bos taurus OX=9913 GN=KCNH6 PE=4 SV=2 CANONICAL=A0AAA9T571-1" }, "locus": { "chromosome": "19", "start_pos": 47864238, "end_pos": 47841787, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022102.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022102.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022102.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022102.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527872", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527872", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7H945-1", "protein_name": "Potassium voltage-gated channel subfamily H member 6", "gene_name": "Kcnh6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKSGSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLNFVEFNLEKHRSGSATEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCSPLTVVDLIVDVMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKHYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIHRADLLEVLDLYPAFADTFWNKLEVTFNLRDADGGLQSSPRQAPSNQEPQAFFINDSQSGAAPSLSISDASGLWPELLQQMPPSPPNPQQDLDCWPRELGSRLEQLQAQMNRLESRMSSDLSRILQLLQQPQGHTGYILGAPASSDLDLLPETSVTQSPEPRLLMGHSAQTLSYGDLNKHIQKPRNFSPRMHHLAVAMDQTPVPSSEQEQPEGLLTPLASSLCPLEVQGLISGPHFPSLPKDLSSVPKQLEFQRHSSDPGFTRS", "length": 949 }, "evidence": [ { "id": "A0AAA9T571", "url": "https://omabrowser.org/oma/group/A0AAA9T571/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A5G2R2U0-1", "protein_name": "Potassium voltage-gated channel subfamily H member 6", "gene_name": "KCNH6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPRSAMSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKRGSRSLSQRLLSPSFLGSEGSHGRPGTQGPGPGRVKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTLLHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGDCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFHGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHARPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFADSFWSKLEVTFNLRDAGGGLQSSPQQASGSQDHQGFFLSDNQSGAAPSLSISDASGLWPELLQQVPPRPSHSPPNPQGDPDCWPRELGSRLEQLQAQMNRLESRMSADLSRILQLLQQPLPQDHTGYILGAPASNDLALFPVSSVTQRPGAGLPQGDVPPAQTPSYGDSDEWSLKRSNSSSKLPPLAMDIDKTLTLCSEEEQPEGLLSPLASPLHPLEVQGLVCGPRFPSLPEHLSSVPKQLEVQRHGSDPGFAGNSH", "length": 906 }, "evidence": [ { "id": "A0AAA9T571", "url": "https://omabrowser.org/oma/group/A0AAA9T571/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZHU5-1", "protein_name": "Potassium voltage-gated channel subfamily H member 6", "gene_name": "KCNH6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPVRRGHVAPQNTYLDTIIRKFEGQNRKFLIANAQMENCAIIYCNDGFCEMFGYSRVEVMQRPCTCDFLTGPDTTKSSIAQLTQALLGSEECKLEILYYRKDTSCFRCLVDVVPVKNEDGVVIMFILNFEDLAQLIAKSSGRSLHHRLSQSWRAGEGRRLKFSLPSLRRLKAQRNSLPTSEFDGVAIDYGKPGGDSLILRDLKTSPKENCVQSETESLLEKERRPSLEADPTLQHPIPKQEPPSLGPRGSYSAWGFIRSRPGGSFHSLRRVSSLDNFEAARSEFQRKFRERRANSEASHVKPNPPNSTSDSDLMKYRTISQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVTERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLNEEQGEEKHWNCSYSCDPLNIIDLIVDIMFIVDIVINFRTTYVNINDEVVSHPGKIAIHYFKGWFLIDMVAAIPFDLLIFRSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYMEHKIGWLDNLGDQIGKRYNDSDLSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPDCLQADICLHLNRTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHYGDVLTTLYFISRGSIEILKEDIVVAILGKNDIFGEPISLYARPGKSNADVRALTYCDLHKIQREDLLEVLDMYPAFSDNFWSNLEITFNLRDADSVPRTPLSEEYDCTYRRVRRRKHSLCQPNKPDPDTGTSDAEQYHTYSELTNPQDPLSKDQWDDVGSSTTPCSQTSDDEAKPGSPTKAEPFPLSKKDDFALPALSLVTASASGTEVSKQAAESSQSYAATPLDIPNMFTFWEDQRPNHHPEPLQHVSLVHSSRDIPLHSDYRPGQIESRLELLQAQLSRLESRMSSDINIILQLLQRQLSQVPPAYSPISPSSHNLAMYGIVPRSLEPLTPCAPLEDEQQTAPGQSPSYAEVEKFHLKSRDSLSSGMHLTVASDETMTVYSEQEHHSPPLLNPEPPHQRAPNAQGLLRGSRFPSLPEHLEASSEHQDIQRHLSDPVLPGS", "length": 1209 }, "evidence": [ { "id": "A0AAA9T571", "url": "https://omabrowser.org/oma/group/A0AAA9T571/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T571", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T571", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T571" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": 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The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8#function" }, { "database": "UniProtKB", "id": "ARBA00003327", "url": "https://www.uniprot.org/uniprotkb/ARBA00003327#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100138853", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8", "locus": {} } ], "crossref": [ { "id": "A0AAA9T5B8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5B8", "database": "AlphaFoldDB", "categories": [] }, { "id": "100138853", "url": "https://www.ncbi.nlm.nih.gov/gene/100138853", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138157", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138157", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:100138853", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138853", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCCGCCQ", "url": "https://omabrowser.org/oma/group/SCCGCCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23262:SF182", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23262:SF182", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010814590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTHSCCSPCCQPTCCEPSCCRPCCPPVCCQTTCCRTTCLKPTCVSSCCQPTCCESSCCRPCCPPTCYQSSENTCCRTSCCKPTCVTTCCQHNCGGSSCCQPCCRPVRCQTTCCRTTCLKPICVTTCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCASSSAGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCQDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPSCC", "length": 255, "header": "tr|A0AAA9T5B8-1|A0AAA9T5B8_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC100138853 PE=4 SV=2 CANONICAL=A0AAA9T5B8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8/entry#A0AAA9T5B8-1", "sequence": { "sequence": "MTHSCCSPCCQPTCCEPSCCRPCCPPVCCQTTCCRTTCLKPTCVSSCCQPTCCESSCCRPCCPPTCYQSSENTCCRTSCCKPTCVTTCCQHNCGGSSCCQPCCRPVRCQTTCCRTTCLKPICVTTCCQPTCCESSCCQPSCPQTCCQITETTCCKPTCVTSCCQPTCCASSSAGQTCGGSNCCQPCCQPASCAPVYCHRTCYHPTCLCLPGCQDQSCGSSCCQPCSRPVCCQTTCCRTTCCRPSCVSSCCQPSCC", "length": 255, "header": "tr|A0AAA9T5B8-1|A0AAA9T5B8_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC100138853 PE=4 SV=2 CANONICAL=A0AAA9T5B8-1" }, "locus": { "chromosome": "19", "start_pos": 41479937, "end_pos": 41479173, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129369.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129369.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093965.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093965.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138157", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138157", "resource": "KEGG Pathway" }, { "id": "bta:100138853", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138853", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZAY4-1", "protein_name": "Keratin associated protein 9-7", "gene_name": "Krtap9-7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNSCCSSCCQPTCCRTTCCRTTCWKPSCVTSCCQPCCQPSCCGSSCCQPCCQTTCCRTCFQPSCVSSCCSTPCCQPCCCVSSCCQPCCRPSCCQSSCCQPCCCESSCCQPRCCISSCCQPCCKPSCCQSSCCKPCCKPFCLNLCCEPACSGPVTCTRTCYQPTSVCVPGCLSQGCGSSCCEPCGC", "length": 186 }, "evidence": [ { "id": "A0AAA9T5B8", "url": "https://omabrowser.org/oma/group/A0AAA9T5B8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5C0-1", "uniprot_ac": "A0AAA9T5C0", "uniprot_id": "A0AAA9T5C0_BOVIN", "mass": { "chemical_mass": 27945.0, "monoisotopic_mass": 27945.0 }, "refseq": {}, "gene_names": [ { "name": "PDCL3", "type": "recommended", "evidence": [ { "id": "A0AAA9T5C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0" } ] } ], "protein_names": [ { "name": "Phosducin-like protein 3", "type": "recommended", "evidence": [ { "id": "A0AAA9T5C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "F1MTW8", "url": "https://www.uniprot.org/uniprotkb/F1MTW8#function" }, { "database": "UniProtKB", "id": "ARBA00045694", "url": "https://www.uniprot.org/uniprotkb/ARBA00045694#function" }, { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDCL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0", "locus": { "chromosome": "11", "start_pos": 5592467, "end_pos": 5581311, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009962", "url": "https://www.ensembl.org/id/ENSBTAG00000009962" } ] } } ], "crossref": [ { "id": "A0AAA9T5C0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5C0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02988", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02988", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR024253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FCEIRAN", "url": "https://omabrowser.org/oma/group/FCEIRAN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MTW8", "url": "https://www.orthodb.org/?gene=F1MTW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45809", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45809", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45809:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45809:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02114", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02114", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTW8", "url": "https://www.uniprot.org/uniprotkb/F1MTW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MTW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "LQSQLNDPNADTEWNDILRKKGILPSKEDLKDLEKEAEEEEQRILQQSIVKTYEDMTLEELEDNEDEFNEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSALARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTLDELEWKLSESGAIKTSLEENPKKPVEDVLLSAVRCSVPAKRDSDSEDD", "length": 244, "header": "tr|A0AAA9T5C0-1|A0AAA9T5C0_BOVIN Isoform 1 of Phosducin-like protein 3 OS=Bos taurus OX=9913 GN=PDCL3 PE=3 SV=1 CANONICAL=A0AAA9T5C0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0/entry#A0AAA9T5C0-1", "sequence": { "sequence": "LQSQLNDPNADTEWNDILRKKGILPSKEDLKDLEKEAEEEEQRILQQSIVKTYEDMTLEELEDNEDEFNEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSALARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTLDELEWKLSESGAIKTSLEENPKKPVEDVLLSAVRCSVPAKRDSDSEDD", "length": 244, "header": "tr|A0AAA9T5C0-1|A0AAA9T5C0_BOVIN Isoform 1 of Phosducin-like protein 3 OS=Bos taurus OX=9913 GN=PDCL3 PE=3 SV=1 CANONICAL=A0AAA9T5C0-1" }, "locus": { "chromosome": "11", "start_pos": 5591747, "end_pos": 5583831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109596.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109596.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090930.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090930.1" } ] } }, { "isoform_ac": "F1MTW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0/entry#F1MTW8-1", "sequence": { "sequence": "MQDPNADTEWNDILRKKGILPSKEDLKDLEKEAEEEEQRILQQSIVKTYEDMTLEELEDNEDEFNEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSALARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTLDELEWKLSESGAIKTSLEENPKKPVEDVLLSAVRCSVPAKRDSDSEDD", "length": 240, "header": "tr|F1MTW8-1|F1MTW8_BOVIN Computationally mapped isoform of Phosducin-like protein 3 OS=Bos taurus OX=9913 GN=PDCL3 PE=3 SV=1 CANONICAL=A0AAA9T5C0-1" }, "locus": { "chromosome": "11", "start_pos": 5591747, "end_pos": 5581371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013139.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013139.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013139.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013139.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AK42-1", "protein_name": "Phosducin-like protein 3", "gene_name": "PDCL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQDPNADTEWNDILRKKGILPSKESLTELEKEAEEEEQQALQQSIVKTYEDMTLEELEDNEDEFNEEDERAIEMYRQQRLAEWKATQMKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHFSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTMDELEWKLSESGAIKTSLEENPKKPIEDMLLSSVRGSGPARRDSDSDDD", "length": 240 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HHK4-1", "protein_name": "Phosducin-like protein 3", "gene_name": "Pdcl3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQDPNADTEWNDILRKKGILPPKESLKELEKEEAEKEEQQLLQQSVVKTYEDMTLEELEENEDEFNEEDERAIEMYRQQRLAEWKATQLKNKFGDVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCSLINQHLSGLARKFPDVKFVKAISTTCIPNYPDRNLPTVFVYLDGDIKAQFIGPLVFSGMNLTRDELEWKLSESGAIKTDLEENPKKPIEDRLLSSVRGSVPMRRDSDSEDD", "length": 241 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12017-1", "protein_name": "Phosducin-like protein 2", "gene_name": "PLP2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQNEPMFQVQVDESEDSEWNDILRAKGVIPERAPSPTAKLEEALEEAIAKQHENRLEDKDLSDLEELEDDEDEDFLEAYKIKRLNEIRKLQERSKFGEVFHINKPEYNKEVTLASQGKKYEGAQTNDNGEEDDGGVYVFVHLSLQSKLQSRILSHLFQSAACKFREIKFVEIPANRAIENYPESNCPTLIVYYRGEVIKNMITLLELGGNNSKMEDFEDFMVKVGAVAEGDNRLIMNRDDEESREERKLHYGEKKSIRSGIRGKFNVGIGGNDDGNINDDDDGFFD", "length": 286 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4KLJ8-1", "protein_name": "Phosducin-like protein 3", "gene_name": "Pdcl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BVF2-1", "protein_name": "Phosducin-like protein 3", "gene_name": "Pdcl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQDPNADTEWNDILRKKGILPPKESLKELEEEEAEKEEQLLQQSVVKTYEDMTLEELEENEDEFSEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTALEENPKKPIQDLLLSSVRGPVPMRRDSDSEDD", "length": 240 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MR62-1", "protein_name": "Phosducin-like protein 2", "gene_name": "PhLP2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQDPNEDTEWNDVLRAKGIIGPKAKEAEITEDQIQKLMDDAIQRRTDLPLNEGQRDKKIDDMSLDELDELEDSEDEAVLEQYRQRRIAEMRATAEKARFGSVREISGQDYVNEVTKAGEGIWVVLHLYANGVPLCALIHHHMQQLAVRFPQTKFVRSVATTCIPNFPEKNLPTIFIYHEGALRKQYIGPLELRGDKLTAEELEFMLGQAGAVPTEITEDPRPQIRDKMLADLEDKSSDFY", "length": 240 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9H2J4-1", "protein_name": "Phosducin-like protein 3", "gene_name": "PDCL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSVVKTYEDMTLEELEDHEDEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIEDVLLSSVRRSVLMKRDSDSEGD", "length": 239 }, "evidence": [ { "id": "A0AAA9T5C0", "url": "https://omabrowser.org/oma/group/A0AAA9T5C0/", "database": "OMA" } ], "glygen_name": 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"pmid": "" }, { "name": "negative regulation of protein folding", "id": "GO:1903333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5C0", "url": 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"length": 1093, "header": "tr|A0A3Q1LZX5-1|A0A3Q1LZX5_BOVIN Computationally mapped isoform of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 OS=Bos taurus OX=9913 GN=SMARCA1 PE=3 SV=3 CANONICAL=A0AAA9T5D6-1" }, "locus": { "chromosome": "X", "start_pos": 13564338, "end_pos": 13491043, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082702.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082702.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061286.3", "url": "https://www.ensembl.org/id/ENSBTAP00000061286.3" } ] } }, { "isoform_ac": "A0AAA9T5D6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6/entry#A0AAA9T5D6-1", "sequence": { "sequence": "MVRQTFYSTVISRGKVLCARRGERPELVPVQTLPPPRSPRPLVRPPPRSRSNAMEPDTAAVAGTVAASDATAAIVLIEDDQPGPSTSKEEGAAAAATAATEATVATEKGEKKKEKNVSPFQLKLAVKASKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDDKQSLISVGDYRHRRTEQEEDEELLSESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVRDFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTKNCLGDQKLVERLHTVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVELLGQREAIEAFNIPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKMAKEEMLQMIRHGATHVFASKESELTDEDITTLLERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPAVAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRKAESATESSGKKDVKKVKS", "length": 1126, "header": "tr|A0AAA9T5D6-1|A0AAA9T5D6_BOVIN Isoform 1 of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 OS=Bos taurus OX=9913 GN=SMARCA1 PE=3 SV=1 CANONICAL=A0AAA9T5D6-1" }, "locus": { "chromosome": "X", "start_pos": 13564871, "end_pos": 13492126, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131353.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131353.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093980.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093980.1" } ] } }, { "isoform_ac": "A0AAA9T616-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6/entry#A0AAA9T616-1", "sequence": { "sequence": "MEPDTAAVAGTVAASDATAAIVLIEDDQPGPSTSKEEGAAAAATAATEATVATEKGEKKKEKNVSPFQLKLAVKASKSEKEMDPEYEEKMKADRAKRFEFLLKQTELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDDKQSLISVGDYRHRRTEQEEDEELLSESRKTSNVCVRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRDEMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVRDFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTKNCLGDQKLVERLHTVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIFSQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREEAIEAFNIPNSSKFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKMAKEEMLQMIRHGATHVFASKESELTDEDITTLLERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKLGMVEWIEPPKRERKANYAVDAYFREALRVSEPKVPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRNPDIPNPAVAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEIEERERAEKKKRATKTPMSQKRKAESATESSGKKDVKKVKS", "length": 1061, "header": "tr|A0AAA9T616-1|A0AAA9T616_BOVIN Computationally mapped isoform of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 OS=Bos taurus OX=9913 GN=SMARCA1 PE=3 SV=1 CANONICAL=A0AAA9T5D6-1" }, "locus": { "chromosome": "X", "start_pos": 13564338, "end_pos": 13492126, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121064.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121064.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091212.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "nucleosome array spacer activity", "id": "GO:0140750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140750", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "CERF complex", "id": "GO:0090537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "ISWI-type complex", "id": "GO:0031010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031010", "evidence": [ { "database": 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[ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1017, "end_pos": 1019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 915, "end_pos": 917, "annotation": 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5E2-1", "uniprot_ac": "A0AAA9T5E2", "uniprot_id": "A0AAA9T5E2_BOVIN", "mass": { "chemical_mass": 36181.0, "monoisotopic_mass": 36181.0 }, "refseq": {}, "gene_names": [ { "name": "IL15RA", "type": "recommended", "evidence": [ { "id": "A0AAA9T5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2" } ] } ], "protein_names": [ { "name": "Interleukin-15 receptor subunit alpha", "type": "recommended", "evidence": [ { "id": "A0AAA9T5E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL15RA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2", "locus": { "chromosome": "13", "start_pos": 17555434, "end_pos": 17517594, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006078", "url": "https://www.ensembl.org/id/ENSBTAG00000006078" } ] } } ], "crossref": [ { "id": "A0AAA9T5E2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5E2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615030", "url": "https://www.ncbi.nlm.nih.gov/gene/615030", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PINCAPA", "url": "https://omabrowser.org/oma/group/PINCAPA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BK44", "url": "https://www.orthodb.org/?gene=E1BK44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15060", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15060", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15060:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15060:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK44", "url": "https://www.uniprot.org/uniprotkb/E1BK44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK44-1", "url": "https://www.uniprot.org/uniprotkb/E1BK44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "EAPVPVPGVGERWVRQLRVRARSGPGRTGQVTKPATPGDSPVVTQRHRPGLAGRGAARSQAAQGPGLLSQSNRRTQARGGDRVEWKPGITCPTPTSVEHADIQVKSYSINSRERYVCNSGFKRKAGTSSLTQCVFNETAKVAHWTTPNLKCIRDPSLSHQRPPSTAAPTGLTPEPESPTPSGKEPDLTSKSDTKVATRPATGPGSRLPSTAPPVGTTGVVSKETTYVPAQTAAKAPEHTYPALQDTPGAYQNNPRVVTAAVSTVTVLFVVCLVFLLGRCLWSRRAHQTPGVEMESMESVPMTTGADARGEDTEIHPHGLGGSGDAEASSGRSEGPALPQSERT", "length": 343, "header": "tr|A0AAA9T5E2-1|A0AAA9T5E2_BOVIN Isoform 1 of Interleukin-15 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL15RA PE=4 SV=1 CANONICAL=A0AAA9T5E2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2/entry#A0AAA9T5E2-1", "sequence": { "sequence": "EAPVPVPGVGERWVRQLRVRARSGPGRTGQVTKPATPGDSPVVTQRHRPGLAGRGAARSQAAQGPGLLSQSNRRTQARGGDRVEWKPGITCPTPTSVEHADIQVKSYSINSRERYVCNSGFKRKAGTSSLTQCVFNETAKVAHWTTPNLKCIRDPSLSHQRPPSTAAPTGLTPEPESPTPSGKEPDLTSKSDTKVATRPATGPGSRLPSTAPPVGTTGVVSKETTYVPAQTAAKAPEHTYPALQDTPGAYQNNPRVVTAAVSTVTVLFVVCLVFLLGRCLWSRRAHQTPGVEMESMESVPMTTGADARGEDTEIHPHGLGGSGDAEASSGRSEGPALPQSERT", "length": 343, "header": "tr|A0AAA9T5E2-1|A0AAA9T5E2_BOVIN Isoform 1 of Interleukin-15 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL15RA PE=4 SV=1 CANONICAL=A0AAA9T5E2-1" }, "locus": { "chromosome": "13", "start_pos": 17554430, "end_pos": 17517793, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093986.1" } ] } }, { "isoform_ac": "E1BK44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2/entry#E1BK44-1", "sequence": { "sequence": "MSGRLRGRGAGALPALGLLLLLLLLGSSATPGITCPTPTSVEHADIQVKSYSINSRERYVCNSGFKRKAGTSSLTQCVFNETAKVAHWTTPNLKCIRDPSLSHQRPPSTAAPTGLTPEPESPTPSGKEPDLTSKSDTKVATRPATGPGSRLPSTAPPVGTTGVVSKETTYVPAQTAAKAPEHTYPALQDTPGAYQNNPRVVTAAVSTVTVLFVVCLVFLLGRCLWSRRAHQTPGVEMESMESVPMTTGADARGEDTEIHPHGLGGSGDAEASSGRSEGPALPQSERT", "length": 287, "header": "tr|E1BK44-1|E1BK44_BOVIN Computationally mapped isoform of Interleukin-15 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL15RA PE=4 SV=3 CANONICAL=A0AAA9T5E2-1" }, "locus": { "chromosome": "13", "start_pos": 17554430, "end_pos": 17518539, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007987.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007987.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007987.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007987.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 179, "start_aa": "Thr", "end_pos": 179, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AI14-1", "protein_name": "Interleukin-15 receptor subunit alpha", "gene_name": "Il15ra", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASPQLRGCGVHALPMLLPLLLLLLLLLPLRVTPGITCPTPISIEHADIRVKNYSVNSRERYVCNSGFKRKAGTSTLTECVINKNTNVAHWTTPNLKCIRDPSLAHYSPVPTVVTPKVTSQPESLSPPEKEPEALSPKSDTTVATETAIVPGSRLTPSQAASAGTTGTGRHKSSPAPSLATTMTLEPTASTSLRITEISPHSSEMTKVAIPTSVLLVAAGIGLVFLTRYIKSRQASQPRRVEVETMETVPMTVRARSKEDEDHTTSETQGDQPTRGV", "length": 277 }, "evidence": [ { "id": "A0AAA9T5E2", "url": "https://omabrowser.org/oma/group/A0AAA9T5E2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GR70-1", "protein_name": "Interleukin-15 receptor subunit alpha", "gene_name": "Il15ra", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSRHLRGCGVHALQVLLLLLLLLLPLRVTPGTTCPTPISVEHADIRVKNYSVNSRERYVCNSGFKRKAGTSSLTECVINKNTNTAHWTTPNLKCIRDPSLAYQSPVLPSTVVTTTVTPQPESPSPPEKEPETVSPKSDTTLATETAIVPGFRLTPSQPASTGTTGTGSHESSRAPSLATTMTLEPTASTSLRIPEISPNSSKMTKVAISTSVLTLLVGAGVVALLVCYIRSRQTSQPHGVEMETMEAVPMTVRPRSNEDDTEA", "length": 264 }, "evidence": [ { "id": "A0AAA9T5E2", "url": "https://omabrowser.org/oma/group/A0AAA9T5E2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q13261-1", "protein_name": "Interleukin-15 receptor subunit alpha", "gene_name": "IL15RA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL", "length": 267 }, "evidence": [ { "id": "A0AAA9T5E2", "url": "https://omabrowser.org/oma/group/A0AAA9T5E2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60819-1", "protein_name": "Interleukin-15 receptor subunit alpha", "gene_name": "Il15ra", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASPQLRGYGVQAIPVLLLLLLLLLLPLRVTPGTTCPPPVSIEHADIRVKNYSVNSRERYVCNSGFKRKAGTSTLIECVINKNTNVAHWTTPSLKCIRDPSLAHYSPVPTVVTPKVTSQPESPSPSAKEPEAFSPKSDTAMTTETAIMPGSRLTPSQTTSAGTTGTGSHKSSRAPSLAATMTLEPTASTSLRITEISPHSSKMTKVAISTSVLLVGAGVVMAFLAWYIKSRQPSQPCRVEVETMETVPMTVRASSKEDEDTGA", "length": 263 }, "evidence": [ { "id": "A0AAA9T5E2", "url": "https://omabrowser.org/oma/group/A0AAA9T5E2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E2", "url": 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"homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 179 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] 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"refseq": {}, "gene_names": [ { "name": "ULBP3", "type": "recommended", "evidence": [ { "id": "A0AAA9T5L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7" } ] } ], "protein_names": [ { "name": "UL16 binding protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T5L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ULBP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7", "locus": {} } ], "crossref": [ { "id": "A0AAA9T5L7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5L7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TDAHSLSYNITIDPRPRDGQPWCEVQGEVDQKVFLSYDCGRAKIKYMSPLGEEVKSMNAWEAQTDTLRDIGDLLKEQMTDVTPEKHLDKGPLTLQARMSCWQEDNGLISASWEFGFNGQLCLLFDSESGYWTMVHSKGRWMKEKWENDRAVTEFFKKVSRADCQRWYQDFLLHWEKMLKTTASPTTGPSTMQRMAPDSSYSTWIATGVLAGFVITIIIIACIHYKKRRRCSQEA", "length": 234, "header": "tr|A0AAA9T5L7-1|A0AAA9T5L7_BOVIN Isoform 1 of UL16 binding protein 3 OS=Bos taurus OX=9913 GN=ULBP3 PE=4 SV=1 CANONICAL=A0AAA9T5L7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7/entry#A0AAA9T5L7-1", "sequence": { "sequence": "TDAHSLSYNITIDPRPRDGQPWCEVQGEVDQKVFLSYDCGRAKIKYMSPLGEEVKSMNAWEAQTDTLRDIGDLLKEQMTDVTPEKHLDKGPLTLQARMSCWQEDNGLISASWEFGFNGQLCLLFDSESGYWTMVHSKGRWMKEKWENDRAVTEFFKKVSRADCQRWYQDFLLHWEKMLKTTASPTTGPSTMQRMAPDSSYSTWIATGVLAGFVITIIIIACIHYKKRRRCSQEA", "length": 234, "header": "tr|A0AAA9T5L7-1|A0AAA9T5L7_BOVIN Isoform 1 of UL16 binding protein 3 OS=Bos taurus OX=9913 GN=ULBP3 PE=4 SV=1 CANONICAL=A0AAA9T5L7-1" }, "locus": { "chromosome": "NKLS02000657.1", "start_pos": 89144, "end_pos": 86430, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101747.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101747.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093119.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093119.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L7" }, { "id": "PF00129", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHC class I-like antigen recognition-like", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 171, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5M5-1", "uniprot_ac": "A0AAA9T5M5", "uniprot_id": "A0AAA9T5M5_BOVIN", "mass": { "chemical_mass": 319042.0, "monoisotopic_mass": 319042.0 }, "refseq": { "ac": "NP_001179119", "name": "biorientation of chromosomes in cell division protein 1-like 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179119" }, "gene_names": [ { "name": "BOD1L1", "type": "recommended", "evidence": [ { "id": "A0AAA9T5M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ] }, { "name": "BOD1L1", "type": "synonym", "evidence": [ { "id": "NP_001179119", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179119" } ] }, { "name": "BOD1L", "type": "synonym", "evidence": [ { "id": "NP_001179119", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179119" } ] } ], "protein_names": [ { "name": "Biorientation of chromosomes in cell division 1 like 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T5M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5/entry#names_and_taxonomy" } ] }, { "name": "biorientation of chromosomes in cell division protein 1-like 1", "type": "synonym", "evidence": [ { "id": "NP_001179119", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179119" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BOD1L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5", "locus": { "chromosome": "6", "start_pos": 108777761, "end_pos": 108831162, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004316", "url": "https://www.ensembl.org/id/ENSBTAG00000004316" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508527", "url": "https://www.ncbi.nlm.nih.gov/gene/508527", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508527", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508527", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CAESQQP", "url": "https://omabrowser.org/oma/group/CAESQQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2G1", "url": "https://www.orthodb.org/?gene=F1N2G1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47391", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47391", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47391:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47391:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179119", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2G1", "url": "https://www.uniprot.org/uniprotkb/F1N2G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2G1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPPPPPPGPGTGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLSHKEDTSGSTAPEDEKPDSSTITQGVPAPGPSANVASDAMSILETITSLNQEASAARASTETSNAKTSERMSKKTPSQASTDTSAEKERTSEDTADKEKPTADSAGEGQEAAPRSEELSDPPCPAEEMKNHARESTSSVLLNKDAQQESSDQKSKSADKGEKKPDSNEKAERKKEKKEKTEKKTDHSKRSEDVQRVKDEKQAKDKEVECSKLPSEKTNSKAKTSEGTKEDISMIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEAVMSESMEEGEITSDDEEKNKQNKTKTQTSDPSEGKAKNVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKYSKAKSQGKSSVDLEESSTKGLEPKAPRIKEVLKERKVLEKKVALSKKRKKDSRNIDENSKKKQQSEEDSRETLKTSEHCEKEKASSSKDLKHVHAKSEPSKPARRLSESLHPADENKNESKIEREHKRRTSTPVVVEGVQEETDTRDGKRPLERSESGTEEPQKQKSTLKNEKHLKKDDSETPHLKSLPKKEAKSSKEKPEKEKTLSEDKPSTKHKYRGDSAHKAGDEPEPHSSERGSRDENVQKTTQQAKLSSDDKAERRGKHRNERKLSVLGKDGKPVSEYIIKSDENVRKENKKERHGSADKTKAEHKSRRSSDSKIQKDSLSSRQHGSTVQRRSESYSEDKCDNDLTNADSNSKPEEAIHKERRRTKSLLEDKLVLKSKSRSQGKQLKASETESQENTTKLATTPKPEKEKNTEEGEPERQRKSRVEDRPSEESGVEPTSESVAPSAHSVQRESSHRAKLPLAKERCKGEKESSSTRLERKLSDGHKSRSLKHSSKDVKKKEDNKTEDKDGKEVDGSHEKPRGSSSVVEKKLSRRLCENRRGSVSQEMAKGEEKPAANPSGAPSSSSLQRPKKSGDPALMPEQEPMEIDPEPAMENAVEVRKTQDGSSSSQQELDSENVTKQKTTAAVLKEELQTPMGESKTASPACKSGRGTGAVGNSEKHADHRSTLTKKMHLQSSVSKPNSEEKESAQQETQEMNVDSEMSHCLLPRAPSESDRAQKNLKNTTRPTEERLAPGDPTLKHSTKVDPAPSLGSMTAGPQKQSHDSGVLPLVDRRSGSEGTTASTSLIHHSEIPKQSWTDEESEVPRTSDSRKGNAVSTVDTPAEASVESRRHIPEGAQAFILHSRQGKVDTPVGSESGDRTVEKENIDKEGGLMDVDGKGSNSSSKQTVRASVENGHKVGVAVDQVVGMSTKTDTIGLKQSRGPAEVENIPADADRRHGHSEVDTSAESNAVSSVLHQRSGKVEIPTARPSRGEKASIASSTEGKDSGVPLNLVKAGTATTTSAETVEGGVAMPCTSIEADEGLTTGTCSENHPLHVGEEAREGTIFAAAEEGGGVVTEGFAESETFLTSTKEGESGECALAEPEERAADPVTAPTGTTEADARSAATEEKDDAVTSAGSEGKCDGSSGGDSELVEGTVRFISEVESDGAVTSAGMDIREGSLSNEELDGFQRSPPRAGPKKESEGTVTCTGAGGRRDGSVLCSAAGVEPQEERRVTGAPGGPIDTPTPTAASAAQEESGSVMDGPEGESAVTSTGITEEDGEGLASCTGSEESREGFALSSESEENEESAMDSTVAKDPTDAPVVAPGPCDDEGVVTSTGAKEDEDEGEGVVTSTGRGNEVGHASTCTGMEEESEGMSVCESAGGDAQLGPVAGRVDAEAGGTVPHAYESTVDSVSGAEKDTKDAEICSSAKGVVESSVSSGAAGEGMAAPASEGRQGPMTSAALDRRDGELSRNEKADDTTPSTGLVGDSYEALVSAAVPEHEPPHTSPGEKDEGDITSVENEDCDGLAVATAIDSVANQAGVAGGSGEGKGLVISTSTTDDLTPQLSTVVDMRAGHSSALRPEESAEGPRVNMEEFEAPMPSAASGDGSQLTAARNEEKDECAMISTSIGEEFEVPISSATALHGAQSPQPVAAVEDRAKALALVSADDFEGPTPSAPAQAESPLASTSKEEKDECALISTSIAEDCEASVCGVSREREHEQPVLEEKDGSAIISTSSGEDCEGPVSSAVTREDAQASVRPAEEASDMAMISTSTSEGCEAVMAGAVPQEEELPAGTGTEDVSDAAIISTSTAECLLAPAGLDRHEEVHLSADSPKGKDAPSATMMSKPEAPLSSLMAEDKCQCPGPSTGGKEVGPVVAGGTGEEHDRVSVSMLSAGVGIVAESERLGKDCADRVQREDERPEAGTSGGSTPARCPAGGSGDSPVNPKGLEQAPEGTISVRCLTAVNPGAKKADDQWGPEGHLKTTTAECINGQESEMAPSHTAALPTAYNVALSAAKQEQNLTSRSDHRGQCTVPASTKKTGEDNSVTKSCQQEGLQVTVSSEENLRDRGRKESPSNAVGRLGLKTNLKPEVFVPSEEEKNHEMPAPPASPSGRKLSGTVELQREPSLAIDSPNVENAGSETTEIHGKFYSKEEISNGGKDNTEAIRCHSAEANPKEVEEEERHIPKRKTKKQYLSSEDELDDTPDVLDSKIETAQRQCSGTEPQDTKEENSGDLEELSKASSKIDSTASRAMEEKDESSSSEAAGEKTEQNDDDTVKSQEDQPVIIKRKRGRPRKHPVETSLKTKDDCKTDAGLVTVEQSPPGGKLKVMQTDETNKETPNLQERSGSNDDSEEKSVASVRRRGRKPKRSLTLSDDAESSEPERKRQKSVSEATEDKKDQESEEEEEEDEDEEPSGATTRSSTRSEAQRSKAQLSPSAKRKREASPPGARTRGQQRVEEILVKKAKR", "length": 2982, "header": "tr|A0AAA9T5M5-1|A0AAA9T5M5_BOVIN Isoform 1 of Biorientation of chromosomes in cell division 1 like 1 OS=Bos taurus OX=9913 GN=BOD1L1 PE=3 SV=1 CANONICAL=A0AAA9T5M5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5/entry#A0AAA9T5M5-1", "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPPPPPPGPGTGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLSHKEDTSGSTAPEDEKPDSSTITQGVPAPGPSANVASDAMSILETITSLNQEASAARASTETSNAKTSERMSKKTPSQASTDTSAEKERTSEDTADKEKPTADSAGEGQEAAPRSEELSDPPCPAEEMKNHARESTSSVLLNKDAQQESSDQKSKSADKGEKKPDSNEKAERKKEKKEKTEKKTDHSKRSEDVQRVKDEKQAKDKEVECSKLPSEKTNSKAKTSEGTKEDISMIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEAVMSESMEEGEITSDDEEKNKQNKTKTQTSDPSEGKAKNVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKYSKAKSQGKSSVDLEESSTKGLEPKAPRIKEVLKERKVLEKKVALSKKRKKDSRNIDENSKKKQQSEEDSRETLKTSEHCEKEKASSSKDLKHVHAKSEPSKPARRLSESLHPADENKNESKIEREHKRRTSTPVVVEGVQEETDTRDGKRPLERSESGTEEPQKQKSTLKNEKHLKKDDSETPHLKSLPKKEAKSSKEKPEKEKTLSEDKPSTKHKYRGDSAHKAGDEPEPHSSERGSRDENVQKTTQQAKLSSDDKAERRGKHRNERKLSVLGKDGKPVSEYIIKSDENVRKENKKERHGSADKTKAEHKSRRSSDSKIQKDSLSSRQHGSTVQRRSESYSEDKCDNDLTNADSNSKPEEAIHKERRRTKSLLEDKLVLKSKSRSQGKQLKASETESQENTTKLATTPKPEKEKNTEEGEPERQRKSRVEDRPSEESGVEPTSESVAPSAHSVQRESSHRAKLPLAKERCKGEKESSSTRLERKLSDGHKSRSLKHSSKDVKKKEDNKTEDKDGKEVDGSHEKPRGSSSVVEKKLSRRLCENRRGSVSQEMAKGEEKPAANPSGAPSSSSLQRPKKSGDPALMPEQEPMEIDPEPAMENAVEVRKTQDGSSSSQQELDSENVTKQKTTAAVLKEELQTPMGESKTASPACKSGRGTGAVGNSEKHADHRSTLTKKMHLQSSVSKPNSEEKESAQQETQEMNVDSEMSHCLLPRAPSESDRAQKNLKNTTRPTEERLAPGDPTLKHSTKVDPAPSLGSMTAGPQKQSHDSGVLPLVDRRSGSEGTTASTSLIHHSEIPKQSWTDEESEVPRTSDSRKGNAVSTVDTPAEASVESRRHIPEGAQAFILHSRQGKVDTPVGSESGDRTVEKENIDKEGGLMDVDGKGSNSSSKQTVRASVENGHKVGVAVDQVVGMSTKTDTIGLKQSRGPAEVENIPADADRRHGHSEVDTSAESNAVSSVLHQRSGKVEIPTARPSRGEKASIASSTEGKDSGVPLNLVKAGTATTTSAETVEGGVAMPCTSIEADEGLTTGTCSENHPLHVGEEAREGTIFAAAEEGGGVVTEGFAESETFLTSTKEGESGECALAEPEERAADPVTAPTGTTEADARSAATEEKDDAVTSAGSEGKCDGSSGGDSELVEGTVRFISEVESDGAVTSAGMDIREGSLSNEELDGFQRSPPRAGPKKESEGTVTCTGAGGRRDGSVLCSAAGVEPQEERRVTGAPGGPIDTPTPTAASAAQEESGSVMDGPEGESAVTSTGITEEDGEGLASCTGSEESREGFALSSESEENEESAMDSTVAKDPTDAPVVAPGPCDDEGVVTSTGAKEDEDEGEGVVTSTGRGNEVGHASTCTGMEEESEGMSVCESAGGDAQLGPVAGRVDAEAGGTVPHAYESTVDSVSGAEKDTKDAEICSSAKGVVESSVSSGAAGEGMAAPASEGRQGPMTSAALDRRDGELSRNEKADDTTPSTGLVGDSYEALVSAAVPEHEPPHTSPGEKDEGDITSVENEDCDGLAVATAIDSVANQAGVAGGSGEGKGLVISTSTTDDLTPQLSTVVDMRAGHSSALRPEESAEGPRVNMEEFEAPMPSAASGDGSQLTAARNEEKDECAMISTSIGEEFEVPISSATALHGAQSPQPVAAVEDRAKALALVSADDFEGPTPSAPAQAESPLASTSKEEKDECALISTSIAEDCEASVCGVSREREHEQPVLEEKDGSAIISTSSGEDCEGPVSSAVTREDAQASVRPAEEASDMAMISTSTSEGCEAVMAGAVPQEEELPAGTGTEDVSDAAIISTSTAECLLAPAGLDRHEEVHLSADSPKGKDAPSATMMSKPEAPLSSLMAEDKCQCPGPSTGGKEVGPVVAGGTGEEHDRVSVSMLSAGVGIVAESERLGKDCADRVQREDERPEAGTSGGSTPARCPAGGSGDSPVNPKGLEQAPEGTISVRCLTAVNPGAKKADDQWGPEGHLKTTTAECINGQESEMAPSHTAALPTAYNVALSAAKQEQNLTSRSDHRGQCTVPASTKKTGEDNSVTKSCQQEGLQVTVSSEENLRDRGRKESPSNAVGRLGLKTNLKPEVFVPSEEEKNHEMPAPPASPSGRKLSGTVELQREPSLAIDSPNVENAGSETTEIHGKFYSKEEISNGGKDNTEAIRCHSAEANPKEVEEEERHIPKRKTKKQYLSSEDELDDTPDVLDSKIETAQRQCSGTEPQDTKEENSGDLEELSKASSKIDSTASRAMEEKDESSSSEAAGEKTEQNDDDTVKSQEDQPVIIKRKRGRPRKHPVETSLKTKDDCKTDAGLVTVEQSPPGGKLKVMQTDETNKETPNLQERSGSNDDSEEKSVASVRRRGRKPKRSLTLSDDAESSEPERKRQKSVSEATEDKKDQESEEEEEEDEDEEPSGATTRSSTRSEAQRSKAQLSPSAKRKREASPPGARTRGQQRVEEILVKKAKR", "length": 2982, "header": "tr|A0AAA9T5M5-1|A0AAA9T5M5_BOVIN Isoform 1 of Biorientation of chromosomes in cell division 1 like 1 OS=Bos taurus OX=9913 GN=BOD1L1 PE=3 SV=1 CANONICAL=A0AAA9T5M5-1" }, "locus": { "chromosome": "6", "start_pos": 108831026, "end_pos": 108779002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092941.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092941.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093129.1" } ] } }, { "isoform_ac": "F1N2G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5/entry#F1N2G1-1", "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPPPPPPGPGTGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLSHKEDTSGSTAPEDEKPDSSTITQGVPAPGPSANVASDAMSILETITSLNQEASAARASTETSNAKTSERMSKKTPSQASTDTSAEKERTSEDTADKEKPTADSAGEGQEAAPRSEELSDPPCPAEEMKNHARESTSSVLLNKDAQQESSDQKSKSADKGEKKPDSNEKAERKKEKKEKTEKKTDHSKRSEDVQRVKDEKQAKDKEVECSKLPSEKTNSKAKTSEGTKEDISMIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEAVMSESMEEGEITSDDEEKNKQNKTKTQTSDPSEGKAKNVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKYSKAKSQGKSSVDLEESSTKGLEPKAPRIKEVLKERKVLEKKVALSKKRKKDSRNIDENSKKKQQSEEDSRETLKTSEHCEKEKASSSKDLKHVHAKSEPSKPARRLSESLHPADENKNESKIEREHKRRTSTPVVVEGVQEETDTRDGKRPLERSESGTEEPQKQKSTLKNEKHLKKDDSETPHLKSLPKKEAKSSKEKPEKEKTLSEDKPSTKHKYRGDSAHKAGDEPEPHSSERGSRDENVQKTTQQAKLSSDDKAERRGKHRNERKLSVLGKDGKPVSEYIIKSDENVRKENKKERHGSADKTKAEHKSRRSSDSKIQKDSLSSRQHGSTVQRRSESYSEDKCDNDLTNADSNSKPEEAIHKERRRTKSLLEDKLVLKSKSRSQGKQLKASETESQENTTKLATTPKPEKEKNTEEGEPERQRKSRVEDRPSEESGVEPTSESVAPSAHSVQRESSHRAKLPLAKERCKGEKESSSTRLERKLSDGHKSRSLKHSSKDVKKKEDNKTEDKDGKEVDGSHEKPRGSSSVVEKKLSRRLCENRRGSVSQEMAKGEEKPAANPSGAPSSSSLQRPKKSGDPALMPEQEPMEIDPEPAMENAVEVRKTQDGSSSSQQELDSENVTKQKTTAAVLKEELQTPMGESKTASPACKSGRGTGAVGNSEKHADHRSTLTKKMHLQSSVSKPNSEEKESAQQETQEMNVDSEMSHCLLPRAPSESDRAQKNLKNTTRPTEERLAPGDPTLKHSTKVDPAPSLGSMTAGPQKQSHDSGVLPLVDRRSGSEGTTASTSLIHHSEIPKQSWTDEESEVPRTSDSRKGNAVSTVDTPAEASVESRRHIPEGAQAFILHSRQGKVDTPVGSESGDRTVEKENIDKEGGLMDVDGKGSNSSSKQTVRASVENGHKVGVAVDQVVGMSTKTDTIGLKQSRGPAEVENIPADADRRHGHSEVDTSAESNAVSSVLHQRSGKVEIPTARPSRGEKASIASSTEGKDSGVPLNLVKAGTATTTSAETVEGGVAMPCTSIEADEGLTTGTCSENHPLHVGEEAREGTIFAAAEEGGGVVTEGFAESETFLTSTKEGESGECALAEPEERAADPVTAPTGTTEADARSAATEEKDDAVTSAGSEGKCDGSSGGDSELVEGTVRFISEVESDGAVTSAGMDIREGSLSNEELDGFQRSPPRAGPKKESEGTVTCTGAGGRRDGSVLCSAAGVEPQEERRVTGAPGGPIDTPTPTAASAAQEESGSVMDGPEGESAVTSTGITEEDGEGLASCTGSEESREGFALSSESEENEESAMDSTVAKDPTDAPVVAPGPCDDEGVVTSTGAKEDEDEGEGVVTSTGRGNEVGHASTCTGMEEESEGMSVCESAGGDAQLGPVAGRVDAEAGGTVPHAYESTVDSVSGAEKDTKDAEICSSAKGVVESSVSSGAAGEGMAAPASEGRQGPMTSAALDRRDGELSRNEKADDTTPSTGLVGDSYEALVSAAVPEHEPPHTSPGEKDEGDITSVENEDCDGLAVATAIDSVANQAGVAGGSGEGKGLVISTSTTDDLTPQLSTVVDMRAGHSSALRPEESAEGPRVNMEEFEAPMPSAASGDGSQLTAARNEEKDECAMISTSIGEEFEVPISSATALHGAQSPQPVAAVEDRAKALALVSADDFEGPTPSAPAQAESPLASTSKEEKDECALISTSIAEDCEASVCGVSREREHEQPVLEEKDGSAIISTSSGEDCEGPVSSAVTREDAQASVRPAEEASDMAMISTSTSEGCEAVMAGAVPQEEELPAGTGTEDVSDAAIISTSTAECLLAPAGLDRHEEVHLSADSPKGKDAPSATMMSKPEAPLSSLMAEDKCQCPGPSTGGKEVGPVVAGGTGEEHDRVSVSMLSAGVGIVAESERLGKDCADRVQREDERPEAGTSGGSTPARCPAGGSGDSPVNPKGLEQAPEGTISVRCLTAVNPGAKKADDQWGPEGHLKTTTAECINGQESEMAPSHTAALPTAYNVALSAAKQEQNLTSRSDHRGQCTVPASTKKTGEDNSVTKSCQQEGLQVTVSSEENLRDRGRKESPSNAVGRLGLKTNLKPEVFVPSEEEKNHEMPAPPASPSGRKLSGTVELQREPSLAIDSPNVENAGSETTEIHGKFYSKEEISNGGKDNTEAIRCHSAEANPKEVEEEERHIPKRKTKKQYLSSEDELDDTPDVLDSKIETAQRQCSGTEPQDTKTNPAAVKLPVKRQSRMTMTP", "length": 2763, "header": "tr|F1N2G1-1|A0AAA9T5M5_BOVIN Computationally mapped isoform of Biorientation of chromosomes in cell division 1 like 1 OS=Bos taurus OX=9913 GN=BOD1L1 PE=3 SV=3 CANONICAL=A0AAA9T5M5-1" }, "locus": { "chromosome": "6", "start_pos": 108831026, "end_pos": 108790378, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033704.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033704.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033614.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033614.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1761, "start_aa": "Thr", "end_pos": 1761, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1761", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2188, "start_aa": "Thr", "end_pos": 2188, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2188", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 969, "start_aa": "Thr", "end_pos": 969, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr969", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508527", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508527", "resource": "KEGG Pathway" }, { "id": "R-BTA-9772755", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9772755", "resource": "Reactome", "description": "Formation of WDR5-containing histone-modifying complexes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y0I4-1", "protein_name": "Biorientation of chromosomes in cell division 1 like 1", "gene_name": "BOD1L1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASNPQPQPPPPPPPPPPPQQQPPLPGAGAGAGSGAAEPELVSMIVSHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVCNHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEAGPSTAPSEEKMDASVAVQGVSTTAPSGNVASDAMSILETITSLNQEASAARASTDNSSSKNSDKAAKRLLSQQSVDGSTERNMEDLPDKEKAISDLSGEGAETFVKCEDSNELPCQSEEMKNSAKDTSSSSVTIKDTSKEIQQDSEDQKSKLIDKCEKKPEGDRRKEKKEKLDKKKSDDTTKSKEEKQVKESEPVKQLVPEKNSNKHKASESTKEEHTSLDSDTDVLSDITVSSVHTSDLSSFEEESEEEPVISDSTEEGEITSDDEEEKNKNKTKPHTNELSDGRAKPVRHAYVRKPFLYSKYFSDSDDERTVEQRRQSIAKEKEERLLRRRMNRERLEEKRKQKTAEKTKSLKSGSQNAKGKSGLNLEEPSARSLESKTTGTSIKDVLKEQKFLEKKVALSRKRKRDSRHVEDGWKKKYEPSEDDSKEAQKTIETCEKNSSKELKHNHGKTETSKPPRRLSESVHSAEENKTDSKVEKEHKRKTSTSLHTEGTQQDIETKDPKRQLERAEANTDELQKQKTVFKNEKHPKKDSDAEIQHMRNAARKEAKSHRDKNEKEVTALEDKLSLKHKCKGDGIHKSVEDVELHSSEKSLKGEDGAQKHNQQMKISSDDKSERKTKHRSERKISVTGKDGKGISDSTLKAEELLRKENKKDRHLSTEKSRAEYKSKRSLSDSRPQKDSTSASKPLSSVSHKRSESYSEEKHEIKSTNSDCNLKQEDGVPKDRRRSKSLAEDKILLKSKSKSHSKQLKSSETELQENLAKQDTSQKLDKDKNMEENDSDKQHNSKNEDKMSEESGADFELESGMQSTQGSQKDSSHRVKLHSGERGSVKEKCRGDKDVSNSRLERKFSVEGHKSRSIKHSNKEIKKKEECTKVEDKDMKEMDGGHEKVMGITVTVDKKQSKKVSCENRKGSISNHNLLGEEKQSVGVTVSSSLPVPQKSNTNSDDMCSGHEGEMMELDLDETKVQEESIVGGKSILNSVQATDAKYTAKEKISSVSKELKHSLADLEASESKFLAAVDKTNKQEDTPNKQVGALDTLSKQTSVDQGLHKEGAYKMGVVSGKSHRILLNAPSKDRASEDSRKPKNFKTVINSNADNVPLAVNSLREDAADPKSMDMDISDFTHSLGSMSSTSKEECHNSDGTSLFEDEAASKNGATQVVYMKQEDSVVLSSIVKGGDDNTKTSNIEKDNEAPHPDEQAMENCAAGSPIQDNDKASKLESTPRSELKIKEESLKTCVTEDCEDVPTKELKKLKKKECLNTDFSTKGERSTMMDNVKQNETCDTYNVIQSSSVLASKREPEEAVKDSVPATGQEGNSSVEDKNESSAVGTSAGSSKLSLLYSSVQTVPATVIGTSTEKIESTVMASSTEERVEGASHSEKESDATTTCSEEESEMALICTSIEADEGFTTGIWVKSGEGSSFITGTDIGECTVTAAEEGGGSVVTEGLAESESFLTSTKEEENDDYAMIDAEESGKDSVNESGVENEDSVNSAGAEEKDDAVTSAGSEEKRKTLTCGGAGKLESSVSCLGEVESDGAVTSAGTESGEGSTSGDSSREFRGNMRAGQVKEHESTVTCTGAEERGPNFIMCSVTGTDAHGEGSVSGACIAVVTNNNTTTGTTGDKCEDTINGESTVTSTGITPEDDAEISVVCTGLEDSNEGFAVCLDTEKCESAMDSTGTKEEASITIVSIGPCDDEGFVTSTGSKEEDEEGEGIVTSTGRGNEEMEHTSTCTGTEGENTLICIGAEEGESSIICIVAEQMEAESGLAGTKINKLTVDSMTDAEKETNCGTNCKSAKGIVESSVTSASADDEDAVAACIEKHEGTLISLHAEDCEGPMTSAMTLQDRGQPGAEEHENAMTCGSGELDGSISSAIPKGDENSFIPADREEKIKGDIISTSTVEGSDAPLHSAIDAEEGPLTVARANESGESSMISVDVEGTEVPMSSTATEFKECVLAFSSKQDKDECTMISTSIVEEFEAPMSSATIEYNGQLPSVKTKERNESTEVSIGTEIYDIPMPSASSAGGDESHSAASSKEEKDECAMISTSVVEEQVILMSGEVTEETVQDISETQSKNETVMISTSTAECFEAPMSSVAAQDENKLTASETEGRYEAAVITTSMAEECEIVLISAAPQTEDQLLVAEGDEEDISPNASEECKIVETTATVDEQFGLAAFNTDARGKGSVIFVGECGGPVLRVATNSEDHDAASSIGNKEEGAVIALSTMEECDSLFTFTVIEESQLDAESSEVKDKSEEVFNTANQIECILSTAGPEKSGNSLLVIGQENETHESVVRGASAASQMTVDSEITEADENSVNLMNVDEALCVEISTETAVSPSPSSEVNEDDEQAEDVLHENITSELSCIISEASVESETLRDINYNSNVLLESDFSEIRTPLPGERTPSLVSASELTVNNHNEETVEAELGEKSGCPVLHVEELYGSNDKMNLVKVDDTGIEVTFQKNNTTFNSGNNGALPKLAEELKFETNLRTEDVFTPPQPEGPKSEEVYVDLHVKELQKDSLQKNSAVERETIHVENLDTQITEEHQSRVIECKTSGIIDKEKCSQLTAQDIGKDDDPSQCSRTKPSNIKEITPCDAAEVSKELVITHTSPASAVEEKDEFTTEQEMFEKTKQRLESNENSVEDNQPVIIKRKRGRPRKHPVEAVQPGGGGESKADMSTGNLQLPTSASRGKSPQRGTDISNKKETANEEEAGKAEMTVRKRGRKPRRSLVQAEETEMLEPERKRRKLTSSEEEIREQEEGEEEDNEEEDESTARPATRLEAQRMQSSKPTTRATSKGSSPSSVSPRKQQKLSAKKRSPSDTKINKSSPSTQQKVQSTKRKREGSPTAVRRKGQQKTEETPVKKAKR", "length": 3025 }, "evidence": [ { "id": "A0AAA9T5M5", "url": "https://omabrowser.org/oma/group/A0AAA9T5M5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9Q6J5-1", "protein_name": "Biorientation of chromosomes in cell division protein 1-like 1", "gene_name": "Bod1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPPPPPPGPGAGPGASGPGSAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEAAGSTAPDDEKPESSVITQGAPAPGPSANVASDAMSILETITSLNQEANAARASTEMSNAKVSERTSRKLSSQPSTDVSTDKERGSEDATEREKATSDSGGDGLEAALKSEEPSDLPCPVEETKNHMKENNSLLLLSKDAQQESTDPKIKSMDKGEKKPDGNEKGERKKEKKEKTEKKIDHSKRNEDTQKVKDERQAKDKEVESTKLPSEKSNSRARAAEGTKEDCSLLDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVVSESMEEGEITSEDEEKNKQNKAKVQPGDSSDGKARGVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRRINREKLEEKRKQKAEKTKSSKVKSQGKSTVDLEDSSAKTLEPKAPRIKEVLKERKVLEKKVALSKRRRKDSRNVDENSKKKPQAEEESKEALKTTEYCEKEKASSKDLRHTHGKGEPSRPARRLSESLHSADENKTESKVEREYKRRTSTPVILEGAQEETDTRDGKKQPERSETNVEETQKQKSTLKNEKYQKKDDPETHGKGLPKKEAKSAKERPEKEKAQSEDKPSSKHKHKGDSVHKMSDETELHSSEKGETEESVRKQGQQTKLSSDDRTERKSKHKSERRLSVLGRDGKPVSEYTIKTDEHARKDNKKEKHLSSEKSKAEHKSRRSSDSKLQKDALSSKQHSVTSQKRSESCSEDKCETDSTNADSSFKPEELPHKERRRTKSLLEDKVVSKSKSKGQSKQTKAAETEAQEGVTRQVTTPKPDKEKNTEDNDTERQRKFKLEDRTSEETVTDPALENTVSSAHSAQKDSGHRAKLASIKEKHKTDKDSTSSKLERKVSDGHRSRSLKHSNKDMKKKEENKPDDKNGKEVDSSHEKGRGNGPVTEKKLSRRLCENRRGSTSQEMAKEDKLVANMSGTTSSSSLQRPKKSTETTSIPEQEPMEIDSEAAVENVSELSKTEDISSNSSQQDTDFENVTKHKATAGVLKDEFRTSMVDSKPAAAVTCKSGRGLAVTSISERHADHKSTLTKKVHSQGNPSKAAPREREPIQRGAQEVSVDSEVSRKALSRAPSENEKGQKNLKGMSKTTEECGTHRNASLEYSTDSDLLSSSGSVTVVPQKESHNSNTIPVIDREAISEGGRASTSLANHSDVPNQYSTVKKSEVHKTNGSKEGNDGFTVDMPTKANGGSKRHLSEDSQATLLYSKESKISIPLADKSMSVTGDNKNINKQRSLMGTAKRESDLKVNPDIKQDSAAGEHVVDLSTRKEAETVRRKHNKEIPTDVERKTENSEVDTSARRDSAPVPQQRHGKMERGAAGSGRRDKAFIATSTEGTDKGIMLNTVKTGDATTTSSEVGEKGTALPCTSIEADEGFMMGACPKKHPLQVGAEASECTVFAAAEEGKGVVTEGFAESEILLTSSKEGESGECAVAESEDRVAGPLAAHTVQAEANVNSITTEEKDDAVTSAGSEEKCGGSACTVEGTATFIGEVESDGAVTSAGTEIRAGSLSSEDVDGSQENRIQVGPKKETEGTVTCTETKGRNDNFICLVTRVETQEQRVVTGADVVQVNAAKPQEANANQGDGSGTDGAEGESAVTSTGITEEDGEASANCTGSEDNREGCAISSETEESAESAMDSTEAKDITNAPLVAAGPCDDEGIVTSTGAKEEDDEDEGVVTSTGRGNEPGHASACTGIEESEGMMVCESGEGGAQIGPTIDHVNAEAGAATVNTNDSNVDSMSGAEKEIKDTNICSSAKGIVESSVTSALAGNSDRPPVLCGSEGPMASASSHHSDSQLTRKETVEDTTISTGLVKGSDDVLVSGEVPECEVGHMSPRKNEECDGLMASTASCDVSNKDSLAGSKSQGNGLMISTSTNACTPQISAVIDVRGGHLSTLSTEEIRDGVRVHREGFEAPMPSAVSGENSQLTASRSEEKDECAMISTSIGEEFELPISSAVTVTCAERQQPVAAVEESTTGPALVSTEDFEVPMPSAPTEAESPLASTSKEEKDECALISTSIAEECEASVFGVSRNAPSVTDGNAVISTSSVEDCEGSVSSAVPQESVCPSVIPVEETGDTAMISTSTSEGREAVMVGTIPTDDDQATTVRGEDLSDAAIISTSTAECVLTCTSLSRHEENQQATHNPEGNGGHLATKQSKCELPMPSLVAERNCKCPGPFRMGKGVGPLMAVGTRGEHDRLPVCEPSVGQGQPGTALCLGEEESHGMDCPGQDLNAKERNTLLSSVQRESKSAEAEAAGDSSTARRTVRKDSERNANSLSETNCLREPEQKPAEDTSGSTHCLTAVNPGAEADGMLPITHAALEYPDHQEPESNLKTTTKCITGQESQMPSSHTGVLSAVCHVAPCASEQEGGLPTKSDHSGTWTSEGSPEKMGHVAGARQSFHREGNLDVTLPPEDNGCGVGNEESPPKGIGGLELSTGLTTEISVSSEEDTSHGVVAAPENPCVGRRRGAAELQMEALLMRESLNVEKSESRINEEIHFESQNKEEICCGRKGSTEALSGCSVEADPEEVEEEEKQISQRNRKPDYSSSEEELDDSPDVLDSRIETAQRQYSETEPHDTKEENSGDVEEFSSVTSKTNSSTGLEDRDEFSSSEGTGEKTEPNEDDGSIKSQEDDHPIIIKRRRGRPRKYPAETAFKSKEDSKTETDITTVEQSSPSGKLKVSQADESNKEIANLEEKSTSNDDSEEKTASMRLRGRKPKRSLTSSDDAESSEPERKRQKSVSETSEDKKDEESDEEEEEEEEEEPLGATTRSATRSEAQRKNHSKPSTRATSKLGIPETISPRNRQKLAKEKLSTSEKVSKSPPLGRSKAQLSPSVKRKREVSPPGARTRGQQKVDENPLKKAKR", "length": 3032 }, "evidence": [ { "id": "A0AAA9T5M5", "url": "https://omabrowser.org/oma/group/A0AAA9T5M5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0RC54-1", "protein_name": "Biorientation of chromosomes in cell division 1-like 1", "gene_name": "Bod1l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPPPPPPGPGAGPGASGPGGAGAGSGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEETAGSTAPDDEKLESSVITQGAPAPGPSANVASDAMSILETITSLNQEANAAARASTEMSNAKASERISRKLSSQPSTDISTDKERGSEDGAEREKVTPDSGGEGLETAPKSEEPNDLPCPVEETKNHTKENSLLFLSKDAQQENSDPKIKSTDKGEKKPDGNEKGERKKEKKEKTEKKIDHSKRNEDTQKVKDERQAKDREAESTKLPSEKISSRARAAEGTKEDCSLVDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVMSESMEEGEITSEDEEKNKQNKTKAQTSDSTDGKARSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRRINREKLEEKRKQKAEKTKSSKAKSQGKSSVDLEDSSTKTLEPKAPRIKEVLKERKVLEKKVALSKRRRKDSRNADESSKKKPQAEEESKEALKTSEHCEKEKASSKDLKHTHGKGEPNRPARRLSESLHSVDDNKTESKVEREYKRRTSTPVVLEGAQEETDSRDGKKQPDRSEINMEETQKQKSTLKNEKYQKKDDPETHGKGLPKKEAKSAKERPEKEKAQSEEKSSSKHKHKSDSVHKVGDETEPHSSEKSEAEESVRKQSQQTKLSSDDKTERKRKHRNERKLSVLGRDGKPVSEYTIKTDEHARKDNKKDKHLSSEKTKAEHKSRRSSDSKLQKDVLSSKQHSVTLQKRSESCSEDKYETDSTNADSSSKPEELLHKERRRTKSLLEEKLVLKSKSKSQGKQIKVAETESQEGVTKQVTTPKPDKEKNTEDNDTERQRKSKLEDRTCEEAVAEPALESAVPSAHSSQKDSGHRAKVASVKEKHKTDKDSTSSKLERRVSDGHRSRSLKHSNKDVKRKEENKPDDKNGKEVDSSHEKGRGNGPVTEKKLSRRLCENRRGSTSQEMAKEDKLAANLSGTASTSSLQRPKKSTETALIPEQEPMEIDSEAAVENVSELSKTEDISSNSSQQDTDFENVTKHKAAAGVLKDELRTSMVDSKPAAAVTCKSGRGLTITSNSEKHADHKSTLTKKVHSQSTASKATPREREPAQRGAQEISVDSEGSRKVLSRALSENEKGQKNLKGVSKTTEECGTHRNASLEFSTDSDLLSSLGSVSVVPQKESHDSSTITVVDREAISEGGKASTSLVNHSDIPNQNLAVKKSEILKTNGSKEGNDGFTVDILAKANGSGKRHLSEDSQAMLLCSKEGKVGIALAGKPSGVIGENKSISKQRSLMGTAKKESDLNVDPDVKQDSAAGEHVVDLTTRKEAETIRRKHNKDPDESKKIPTDIERKTENSEVDTSARRDSAPVPQQRHGKMERGAAGSGRRDKSFIATSTEGTDKGIMLNTIKAGDATTTSSETGGKGVALPCTSIEADEGFIMGACPRNNPLQVGAEASECTVFAAAEEGKGVVTEGFAESEILLTSSKEGESGECTVAESEDRVAGPLTAHTVQAETNVNSITTEEKDDAVTSAGSEEKCGGSSCAVEGTATFVGEVESDGAVTSAGTEIRAGSVSSEDVDGSQENRIQVGPKKETEGTVTCTGAKGRNDNFVFCLVTGAGTQEQRVVTGADVVQENDDKSLEASANQGDGSGTDGTEGESAVTSTGITEEDGEASANCTGSEDSTEGCAISSETEENAESAMDSTEAKDMTNTPLVATGPCDDEGIVTSTGAKEEDEEDEGVVTSTGRGNETGHASACTGIEESEGMLVCESGEGGGPIGPTMDHVDAEAGAAAMNTNDSNVDSMSGAEKEIKDTDICSSAKGIVESSVTSAFAGNSDRPPVLESSENPMASATSHHSDSQLTRKETVEDTTISTGLVRGSDDVLLSGAVPEYEVGHMSPRENEECDGLMASTASCDVSNKDSLAGSKSQGNGLVIPTSTNDCTPPISAVIDVRGGHSCTLSTEENRNDARVHMEGFEAPMPSAISDEKSQLTASRSEEKDECAMISTSIGEEFEVPISSAVTITCAERQQPVAAVEESTTGPALVSTEDFEIPMPSAPTEAESPLASTSKEEKDECALISTSIAEECEASASGVSRNAPSDGNAVISTSSVEDCEGSVSSAVPQESVCPSVVPVEETGDTAMISTSTSEGREAVMVGTIPTDEDQASTVRGEDLSDAAIISTSTAECVLTCTSLSRHEESQQASTHNPRGNGGRLVTKQSKCELPMPSLMTESNCKCPGPFTTGKGVGPLMAVSTRGEHDRLPVCEPSAGQSQPGTALCLGEEKSHGMDCPGQDLNAKERNTLLSCVQRESKSVEAEAAGDSSTASGIVRKDSERNANSLSETNCLRRPEQKSAEDSSGSIHCLAAVNTGAKTDNMLPITDAASECPSDQQEPENNLKATTKCITGQESKMPSSHTAVLPSVCRVAPSAPKREGGLPAKSDHSGTWTSEGSAEKMGHVAGARQSYHREGNLDVTIPPEDNGCGIGNEELPPKGIEGSELSANLTTEISVSSEEDTNHGVVAAPENPCVGRPSGAAELQVEALLMSESLNVENSESRINEEIHYDSRNKEEISCGRKDSTEALSGCSAEADPEEVEEEERHISKRNRKQDYSSEEEELDDSPDVLDSRIQTAQRQCSETEPHDTKEENSGDLEEFSTLNSKANSSPALEDRDEFSSSEGTGEKIEPNEDDGSVKSQEDDQPIIIKRKRGRPRKYPAETAFKSKEDSKTETDITTVEQSPPGDKLKVSQADEFNKETTDLQEKSTSNDDNEEKTGSVRRRGRKPKRSLTSSDDAESSEPERKRQKPFSETSEDKNDQDSDEEEEEEDEDEPLGATTRSATRSEAQRKNHSKPSTRATSKLGIPETVSPRNRQKLAKEKLSTSEKVSKSPPLGRSKAQLSPSVKRKRELSPPGARTRGQQKVDETPLKKAKR", "length": 3039 }, "evidence": [ { "id": "A0AAA9T5M5", "url": "https://omabrowser.org/oma/group/A0AAA9T5M5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NFC6-1", "protein_name": "Biorientation of chromosomes in cell division protein 1-like 1", "gene_name": "BOD1L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATNPQPQPPPPAPPPPPPQPQPQPPPPPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR", "length": 3051 }, "evidence": [ { "id": "A0AAA9T5M5", "url": "https://omabrowser.org/oma/group/A0AAA9T5M5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ], "pmid": "" }, { "name": "Set1C/COMPASS complex", "id": "GO:0048188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1034, "end_pos": 1036, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1148, "end_pos": 1150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1254, "end_pos": 1256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1413, "end_pos": 1415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2536, "end_pos": 2538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 927, "end_pos": 929, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M5" }, { "id": "PF05205", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05205" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BOD1/SHG1", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 150, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 969, 1761, 2188 ], "snv_sites": [], 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], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5N9-1", "uniprot_ac": "A0AAA9T5N9", "uniprot_id": "A0AAA9T5N9_BOVIN", "mass": { "chemical_mass": 46761.0, "monoisotopic_mass": 46761.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Coiled-coil and C2 domain containing 2B", "type": "recommended", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9", "locus": {} } ], "crossref": [ { "id": "A0AAA9T5N9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5N9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056288", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11717", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11717:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20837:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20837:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01451", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01451", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24656", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24656", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "15017", "url": "https://www.rhea-db.org/rhea/15017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MR31", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIIEKHEDRCFKSCSGHSYIRKNWLGSIVFPFSALLQQSEFSDQIDILERARIFTKNCKALFPKRRITTTVFNDEGIQILVIRYIKALNPPQQLLDMFLHDSNARLDLVAHFVSLIPIMPEALDENNGFDIWMTSERCITLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVLTQETDEYLLWNPLTGRCHKQFDPFCPLQGVDCLFDGENVWFNLQQNNSPMAVYFDYSKESFWKQLLPKNYQGTKTQSIQPEEIIYSDTNKSMVEDLKNRIERTLKCKIMEWRPKQPTRWNRQCTFILRQILPKLELGTGSFVSSEEESEFERLLQFYWVTGFPIQMPYTDVQSVIDAVYQTGIHSSEFPQTEFALAVYIHPYPNNILSVWVYLASLARHQ", "length": 401, "header": "tr|A0AAA9T5N9-1|A0AAA9T5N9_BOVIN Isoform 1 of Coiled-coil and C2 domain containing 2B OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T5N9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MR31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9/entry#A0A3Q1MR31-1", "sequence": { "sequence": "MIIEKHEDRCFKSCSGHSYIRKNWLGSIVFPFSALLQQSEISGTFQVNIPPVLLGYTWSKTYVSPKEDYNGQNLKESTFLNIFATIEPQISYAICSPELDKFSDQIDILERARIFTKNCKALFPKRRITTTVFNDEGIQILVIRYIKALNPPQQLLDMFLHDSNARLDLVAHFVSLIPIMPEALDENNGFDIWMTSEPVRTDVATSVVKPLKWGKMAEQVTKSVLFVCLGNICRLPIAEAVFRKLVTDQNISDNWIIDSGAVSDWNVGRSPDPRAVSCLRNHGINTAHKARQVTKEDFVTFDYILCMDESNLRDLNRKSNQVKNCRAKIKLLGSYDPQKQLIIEDPYYGNDADFETVYQQCVRCCRAFLEKVH", "length": 373, "header": "tr|A0A3Q1MR31-1|A0A3Q1MR31_BOVIN Computationally mapped isoform of Low molecular weight phosphotyrosine protein phosphatase OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0AAA9T5N9-1" }, "locus": { "chromosome": "26", "start_pos": 17383468, "end_pos": 17372657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068042.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068042.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056837.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056837.2" } ] } }, { "isoform_ac": "A0AAA9T5N9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9/entry#A0AAA9T5N9-1", "sequence": { "sequence": "MIIEKHEDRCFKSCSGHSYIRKNWLGSIVFPFSALLQQSEFSDQIDILERARIFTKNCKALFPKRRITTTVFNDEGIQILVIRYIKALNPPQQLLDMFLHDSNARLDLVAHFVSLIPIMPEALDENNGFDIWMTSERCITLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVLTQETDEYLLWNPLTGRCHKQFDPFCPLQGVDCLFDGENVWFNLQQNNSPMAVYFDYSKESFWKQLLPKNYQGTKTQSIQPEEIIYSDTNKSMVEDLKNRIERTLKCKIMEWRPKQPTRWNRQCTFILRQILPKLELGTGSFVSSEEESEFERLLQFYWVTGFPIQMPYTDVQSVIDAVYQTGIHSSEFPQTEFALAVYIHPYPNNILSVWVYLASLARHQ", "length": 401, "header": "tr|A0AAA9T5N9-1|A0AAA9T5N9_BOVIN Isoform 1 of Coiled-coil and C2 domain containing 2B OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T5N9-1" }, "locus": { "chromosome": "26", "start_pos": 17401134, "end_pos": 17372657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127984.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127984.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091058.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091058.1" } ] } }, { "isoform_ac": "A0AAA9TXC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9/entry#A0AAA9TXC3-1", "sequence": { "sequence": "MIIEKHEDRCFKSCSGHSYIRKNWLGSIVFPFSALLQQSEFSDQIDILERARIFTKNCKALFPKRRITTTVFNDEGIQILVIRYIKALNPPQQLLDMFLHDSNARLDLVAHFVSLIPIMPEALDENNGFDIWMTSERCITLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVLTQETDEYLLWNPLTGRCHKQFDPFCPLQGVDCLFDGENVWFNLQQNNSPMAVYFDYSKESFWKQLLPKNYQGTKTQSIQVTGFPIQMPYTDVQSVIDAVYQTGIHSSEFPQTEFALAVYIHPYPNNILSVWVYLASLARHQ", "length": 322, "header": "tr|A0AAA9TXC3-1|A0AAA9TXC3_BOVIN Computationally mapped isoform of Coiled-coil and C2 domain containing 2B OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T5N9-1" }, "locus": { "chromosome": "26", "start_pos": 17401134, "end_pos": 17372657, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107105.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107105.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102986.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "acid phosphatase activity", "id": "GO:0003993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5N9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "15017", "name": "", "equation": "a phosphate monoester + H2O = an alcohol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6Z8C2-1", "F1MUZ7-1", "E1B8A0-1", "A0AAF6Z8S7-1", "P09487-1", "A6H730-1", "P19111-1", "P11064-1", "A0A3Q1MCB1-1", "Q0P5F0-1", "A0A3Q1LSG5-1", "A0AAA9T5N9-1", "A0A3Q1N8V6-1", "A6H757-1" ], "evidence": [ { "id": "15017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15017" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0AAF6Z8S7", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8S7" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H757", "gene_name": "ACP6", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1B8A0", "gene_name": "ACP5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "E1B8A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8A0" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MUZ7", "gene_name": "ACP7", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "F1MUZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUZ7" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P19111", "gene_name": "ALPI", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P19111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19111" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0P5F0", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q0P5F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F0" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" }, { "id": "PF24656", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24656" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP76/DRC7 peptidase-like", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 246, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" }, { "id": "PF24652", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24652" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Centrosomal protein of 76 kDa C-terminal", "eco_id": "ECO_0000259", "start_pos": 274, "end_pos": 395, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.2", "ec_name": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "3.1.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2" }, { "id": "3.1.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.2" } ] }, { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 270, "end_pos": 272 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"A0AAA9T5P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGPDPGPEPTMEGDVLDTLEALGYKGPLLEEQALTKAAESGLSSPEFSELCVWLSSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGDIKDRLKKKDDCLKLLLFLSTELQALQILQNKKCKNSQLDKNSEIYQEVQAICDTLGIPKSTTSDIPLMLNQVESKVKDILSKVQKNHVGKPLLKIDLNLEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKLKTDDIARIYQPKRYALSPKTTITLAHLLAAREDLSKIIRTSSGSSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGSGRGGWGGGGGRGGGGSGRGGGGGGGGWGGGGGGGWGGAGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGYRRY", "length": 422, "header": "tr|A0AAA9T5P2-1|A0AAA9T5P2_BOVIN Isoform 1 of Family with sequence similarity 98 member B OS=Bos taurus OX=9913 GN=FAM98B PE=3 SV=1 CANONICAL=A0AAA9T5P2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P2/entry#A0AAA9T5P2-1", "sequence": { "sequence": "MRGPDPGPEPTMEGDVLDTLEALGYKGPLLEEQALTKAAESGLSSPEFSELCVWLSSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGDIKDRLKKKDDCLKLLLFLSTELQALQILQNKKCKNSQLDKNSEIYQEVQAICDTLGIPKSTTSDIPLMLNQVESKVKDILSKVQKNHVGKPLLKIDLNLEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKLKTDDIARIYQPKRYALSPKTTITLAHLLAAREDLSKIIRTSSGSSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGSGRGGWGGGGGRGGGGSGRGGGGGGGGWGGGGGGGWGGAGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGYRRY", "length": 422, "header": "tr|A0AAA9T5P2-1|A0AAA9T5P2_BOVIN Isoform 1 of Family with sequence similarity 98 member B OS=Bos taurus OX=9913 GN=FAM98B PE=3 SV=1 CANONICAL=A0AAA9T5P2-1" }, "locus": { "chromosome": "10", "start_pos": 34092919, "end_pos": 34060135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122984.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122984.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091883.1" } ] } }, { "isoform_ac": "A0AAA9TK85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5P2/entry#A0AAA9TK85-1", "sequence": { "sequence": "MRGPDPGPEPTMEGDVLDTLEALGYKGPLLEEQALTKAAESGLSSPEFSELCVWLSSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGDIKDRLKKKDDCLKLLLFLSTELQALQILQNKKCKNSQLDKNSEIYQEVQAICDTLGIPKSTTSDIPLMLNQVESKVKDILSKVQKNHVGKPLLKIDLNLEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKLKTDDIARIYQPKRYALSPKTTITLAHLLAAREDLSKIIRTSSGSSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGSGGWGGAGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGYRRY", "length": 390, "header": "tr|A0AAA9TK85-1|A0AAA9TK85_BOVIN Computationally mapped isoform of Family with sequence similarity 98 member B OS=Bos taurus OX=9913 GN=FAM98B PE=3 SV=1 CANONICAL=A0AAA9T5P2-1" }, "locus": { "chromosome": "10", "start_pos": 34092919, "end_pos": 34060135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112989.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112989.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097606.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532711", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532711", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AE02-1", "protein_name": "Family with sequence similarity 98, member B", "gene_name": "Fam98b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRGPELGPETSMEGDVLDTLEALGYKGPLLEEQALSKAAEGGLSSPEFSELCIWLGSQIKSLCNLEESITSAGRDDLEGFQLEISGFLKEMACPYSVLVSGDIKERLTTKDDCLKLLLFLSTELQALQILQKKKHKNSQLDKNSEICQEVQAICDALGVPKSDTSDIPLLLSHVESKVKDILSKVQKSHVGKPLLKVDLTSEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKAKTDNIARIYQPKRYALSPKTTVTLAHLLAAREDLSKIIRTSSGISREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGRGGWGGGGGGRGGGGGGRGGWGGGGGGWGGGGGGGGGGGGGGWGGSGGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGGGYRRY", "length": 434 }, "evidence": [ { "id": "A0AAA9T5P2", "url": "https://omabrowser.org/oma/group/A0AAA9T5P2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SS16-1", "protein_name": "Family with sequence similarity 98 member B", "gene_name": "FAM98B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRGPEPGPEPTMEGDVLDTLEALGYKGPLLEEQALIKAAEGGLASPEFSELCVWLGSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMVCPYSVLISGDIKDRLKKKDDCLKLLLFLSTELQALQIIQNKKCKNSQLDKNSEIYQEVQAICDTLGVPKSTTSDIPLMLSQVESKVKDILSKVQKNHVGKPLLKIDLNLEQAEQLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKVKTDDIARIYQPKRYALSPKTTITLAHLLAAREDLSKIIRTSSGSSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGRGGWGGGGGGGGRGGGGGGRGGWGGGGGWGGGGGGGGGWSGGGGGGGRGGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGYRRY", "length": 428 }, "evidence": [ { "id": "A0AAA9T5P2", "url": "https://omabrowser.org/oma/group/A0AAA9T5P2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q52LJ0-2", "protein_name": "tRNA-splicing ligase complex subunit FAM98B", "gene_name": "FAM98B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGPEPGPQPTMEGDVLDTLEALGYKGPLLEEQALTKAAEGGLSSPEFSELCIWLGSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLISGDIKDRLKKKEDCLKLLLFLSTELQASQILQNKKHKNSQLDKNSEVYQEVQAMFDTLGIPKSTTSDIPHMLNQVESKVKDILSKVQKNHVGKPLLKMDLNSEQAEQLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKVKTDDIARIYQPKRYALSPKTTITMAHLLAAREDLSKIIRTSSGTSREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGGRGGWGGGGGGGGRGGGGGGGGRGGWGGGGGGWGGGGGGGGGWGGGGGGGRGGFQGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGGGGGGGGGGYRRY", "length": 433 }, "evidence": [ { "id": "A0AAA9T5P2", "url": "https://omabrowser.org/oma/group/A0AAA9T5P2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80VD1-1", "protein_name": "tRNA-splicing ligase complex subunit FAM98B", "gene_name": "Fam98b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGPELGPETSMEGDVLDTLEALGYKGPLLEEQALSKAAEGGLSSPEFSELCIWLGSQIKSLCNLEESITSAGRDDLESFQLEISGFLKEMACPYSVLVSGDIKERLTKKDDCLKLLLFLSTELQALQILQKKKHKNSQLDKNSEICQEVQAVCDALGVPKSDTSDIPLLLSQVESKVKDILCRVQKNHVGKPLLKVDLSSEQAEKLERINDALSCEYECRRRMLMKRLDVTVQSFGWSDRAKAKTDNIARIYQPKRYALSPKTTVTLAHLLAAREDLSKIIRTSSGISREKTACAINKVLMGRVPDRGGRPNEIEPPPPEMPPWQKRQEGGGRGGWGGGGGGRGGGGGGRGGWGGGGGWGGGGGSGGGWGGSGGGGGGRGGFQGRGDYGGRGDYGGRGGYGGRGGYGGRGYGDPYGGGGGGGGGYRRY", "length": 429 }, "evidence": [ { "id": "A0AAA9T5P2", "url": "https://omabrowser.org/oma/group/A0AAA9T5P2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VBK9-1", "protein_name": "Protein FAM98B", "gene_name": "Dmel\\CG5913", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377131" }, "gene_names": [ { "name": "OR1L13", "type": "recommended", "evidence": [ { "id": "A0AAA9T5Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q7" } ] }, { "name": "OR1L13", "type": "synonym", "evidence": [ { "id": "NP_001377131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377131" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T5Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1L8", "type": "synonym", "evidence": [ { "id": "NP_001377131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377131" } ] }, { "name": "olfactory receptor family 1 subfamily L member 13", "type": "synonym", "evidence": [ { "id": "NP_001377131", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377131" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377131" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5Q7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1L13", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q7", "locus": { "chromosome": "11", "start_pos": 93455938, "end_pos": 93456876, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068385", "url": "https://www.ensembl.org/id/ENSBTAG00000068385" } ] } } ], "crossref": [ { "id": "A0AAA9T5Q7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5Q7", "database": "AlphaFoldDB", "categories": [] }, { "id": "615170", "url": "https://www.ncbi.nlm.nih.gov/gene/615170", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615170", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615170", "database": "KEGG Pathway", "categories": [ 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"evidence": [ { "database": "UniProtKB", "id": "A0AAA9T661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T661" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T661", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T661" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T661" }, { "id": "SM00406", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Immunoglobulin V-set", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 98, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T674-1", "uniprot_ac": "A0AAA9T674", "uniprot_id": "A0AAA9T674_BOVIN", "mass": { "chemical_mass": 61126.0, "monoisotopic_mass": 61126.0 }, "refseq": {}, "gene_names": [ { "name": "DDX56", "type": "recommended", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ], "protein_names": [ { "name": "Probable ATP-dependent RNA helicase DDX56", "type": "recommended", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674/entry#names_and_taxonomy" } ] }, { "name": "DEAD box protein 56", "type": "synonym", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells. Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex. Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674#function" }, { "database": "UniProtKB", "id": "ARBA00058156", "url": "https://www.uniprot.org/uniprotkb/ARBA00058156#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674", "locus": { "chromosome": "4", "start_pos": 76875298, "end_pos": 76865589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010602", "url": "https://www.ensembl.org/id/ENSBTAG00000010602" } ] } } ], "crossref": [ { "id": "A0AAA9T674", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T674", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17961", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17961", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVC5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YVC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGPPVKGKHRGKGPKRDKASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKAKTQNPLRSFKHRGEKCRPTAAPS", "length": 545, "header": "tr|A0AAA9T674-1|A0AAA9T674_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus OX=9913 GN=DDX56 PE=3 SV=1 CANONICAL=A0AAA9T674-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T674-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674/entry#A0AAA9T674-1", "sequence": { "sequence": "MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGPPVKGKHRGKGPKRDKASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKAKTQNPLRSFKHRGEKCRPTAAPS", "length": 545, "header": "tr|A0AAA9T674-1|A0AAA9T674_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus OX=9913 GN=DDX56 PE=3 SV=1 CANONICAL=A0AAA9T674-1" }, "locus": { "chromosome": "4", "start_pos": 76874294, "end_pos": 76865607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128601.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128601.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093375.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093375.1" } ] } }, { "isoform_ac": "A0AAF6YVC5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674/entry#A0AAF6YVC5-1", "sequence": { "sequence": "MEDPESLGFEHMGLDHRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRALVLVPTKELARQAQSMIQQLAAYCARDIRVANVSAAEDSASQRAVLMEKPDVVVGTPSRILNHLQQDNLKLRDSMELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELVLHNPVTLKLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPACVLNGELPLRSRASDPEAGVARGIDFHHVCAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQSQLGKIEELLSGDSGAPVLLPYQFHMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPLHPAVVKPHLGNVPDYLVPPALRGLVHPHKKRKKPLASKKAKKAKTQNPLRSFKHRGEKCRPTAAPS", "length": 506, "header": "tr|A0AAF6YVC5-1|A0AAF6YVC5_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=DDX56 PE=3 SV=1 CANONICAL=A0AAA9T674-1" }, "locus": { "chromosome": "4", "start_pos": 76874294, "end_pos": 76865607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014014.4", "url": "https://www.ensembl.org/id/ENSBTAT00000014014.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014014.3", "url": "https://www.ensembl.org/id/ENSBTAP00000014014.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 365, "start_aa": "Thr", "end_pos": 365, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr365", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "RNA stem-loop binding", "id": "GO:0035613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035613", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" }, { "name": "negative regulation of type I interferon production", "id": "GO:0032480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032480", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T674", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": 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"https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": 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"VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": 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"A0AAA9T679", "uniprot_id": "A0AAA9T679_BOVIN", "mass": { "chemical_mass": 11331.0, "monoisotopic_mass": 11331.0 }, "refseq": {}, "gene_names": [ { "name": "SPINT4", "type": "recommended", "evidence": [ { "id": "A0AAA9T679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679" } ] } ], "protein_names": [ { "name": "Serine peptidase inhibitor, Kunitz type 4", "type": "synonym", "evidence": [ { "id": "A0AAA9T679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T679", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPINT4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679", "locus": { "chromosome": "13", "start_pos": 74515027, "end_pos": 74511229, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059190", "url": "https://www.ensembl.org/id/ENSBTAG00000059190" } ] } } ], "crossref": [ { "id": "A0AAA9T679", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T679", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00109", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00109", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002223", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002223", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47898", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47898", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47898:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47898:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T679", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T679-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLIELGFLLGLFTSLLTTPLMGGMTQITDMICKKFKDRCKMPLNFGSCYDIQFRYFYNITSGLCESFVYTGCDGNLNNYRLKIECQMTCEKKYIKPS", "length": 98, "header": "tr|A0AAA9T679-1|A0AAA9T679_BOVIN Isoform 1 of Serine peptidase inhibitor, Kunitz type 4 OS=Bos taurus OX=9913 GN=SPINT4 PE=4 SV=1 CANONICAL=A0AAA9T679-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T679-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679/entry#A0AAA9T679-1", "sequence": { "sequence": "MKLIELGFLLGLFTSLLTTPLMGGMTQITDMICKKFKDRCKMPLNFGSCYDIQFRYFYNITSGLCESFVYTGCDGNLNNYRLKIECQMTCEKKYIKPS", "length": 98, "header": "tr|A0AAA9T679-1|A0AAA9T679_BOVIN Isoform 1 of Serine peptidase inhibitor, Kunitz type 4 OS=Bos taurus OX=9913 GN=SPINT4 PE=4 SV=1 CANONICAL=A0AAA9T679-1" }, "locus": { "chromosome": "13", "start_pos": 74515027, "end_pos": 74511229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091289.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T679", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T679" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T679", "database": "UniProtKB", "url": 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6A3-1", "uniprot_ac": "A0AAA9T6A3", "uniprot_id": "A0AAA9T6A3_BOVIN", "mass": { "chemical_mass": 53165.0, "monoisotopic_mass": 53165.0 }, "refseq": {}, "gene_names": [ { "name": "FBXL3", "type": "recommended", "evidence": [ { "id": "A0AAA9T6A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3" } ] } ], "protein_names": [ { "name": "F-box/LRR-repeat protein 21", "type": "recommended", "evidence": [ { "id": "A0AAA9T6A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3/entry#names_and_taxonomy" } ] }, { "name": "F-box and leucine-rich repeat protein 21", "type": "synonym", "evidence": [ { "id": "A0AAA9T6A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3#function" }, { "database": "UniProtKB", "id": "ARBA00058466", "url": "https://www.uniprot.org/uniprotkb/ARBA00058466#function" }, { "database": "UniProtKB", "id": "A0AAA9T875", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T875#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3", "locus": { "chromosome": "12", "start_pos": 52117531, "end_pos": 52137817, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018848", "url": "https://www.ensembl.org/id/ENSBTAG00000018848" } ] } } ], "crossref": [ { "id": "A0AAA9T6A3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6A3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd22178", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22178", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23957", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23957", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540712", "url": "https://www.ncbi.nlm.nih.gov/gene/540712", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10224:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10224:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T6A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6A3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T875", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T875", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T875-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T875-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLH7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKRPSLGALLNLGEVDHPSSLHSSSSVRGIFTFTQVRSRSVTMKRGGGRDSGHDSSEEGIAEKSKRLRAASEHSQTCDWGNLLQDIVLQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW", "length": 471, "header": "tr|A0AAA9T6A3-1|A0AAA9T6A3_BOVIN Isoform 1 of F-box/LRR-repeat protein 21 OS=Bos taurus OX=9913 GN=FBXL3 PE=4 SV=1 CANONICAL=A0AAA9T6A3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6A3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3/entry#A0AAA9T6A3-1", "sequence": { "sequence": "MKRPSLGALLNLGEVDHPSSLHSSSSVRGIFTFTQVRSRSVTMKRGGGRDSGHDSSEEGIAEKSKRLRAASEHSQTCDWGNLLQDIVLQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW", "length": 471, "header": "tr|A0AAA9T6A3-1|A0AAA9T6A3_BOVIN Isoform 1 of F-box/LRR-repeat protein 21 OS=Bos taurus OX=9913 GN=FBXL3 PE=4 SV=1 CANONICAL=A0AAA9T6A3-1" }, "locus": { "chromosome": "12", "start_pos": 52136425, "end_pos": 52119375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132187.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132187.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092098.1" } ] } }, { "isoform_ac": "A0AAA9T875-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3/entry#A0AAA9T875-1", "sequence": { "sequence": "MKRGGGRDSGHDSSEEGIAEKSKRLRAASEHSQTCDWGNLLQDIVLQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW", "length": 429, "header": "tr|A0AAA9T875-1|A0AAA9T875_BOVIN Computationally mapped isoform of F-box/LRR-repeat protein 21 OS=Bos taurus OX=9913 GN=FBXL3 PE=4 SV=1 CANONICAL=A0AAA9T6A3-1" }, "locus": { "chromosome": "12", "start_pos": 52133009, "end_pos": 52119375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106029.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106029.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092045.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092045.1" } ] } }, { "isoform_ac": "A0AAF6DLH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A3/entry#A0AAF6DLH7-1", "sequence": { "sequence": "MKRGGGRDSGHDSSEEGIAEKSKRLRAAICRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW", "length": 395, "header": "tr|A0AAF6DLH7-1|A0AAF6DLH7_BOVIN Computationally mapped isoform of F-box and leucine rich repeat protein 3 OS=Bos taurus OX=9913 GN=FBXL3 PE=4 SV=1 CANONICAL=A0AAA9T6A3-1" }, "locus": { "chromosome": "12", "start_pos": 52133009, "end_pos": 52119375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920" }, "gene_names": [ { "name": "OR51F23", "type": "recommended", "evidence": [ { "id": "A0AAA9T6I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9" } ] }, { "name": "OR51F23", "type": "synonym", "evidence": [ { "id": "NP_001376920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T6I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 51F2", "type": "synonym", "evidence": [ { "id": "NP_001376920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920" } ] }, { "name": "olfactory receptor family 51 subfamily F member 23", "type": "synonym", "evidence": [ { "id": "NP_001376920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51F23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9", "locus": { "chromosome": "15", "start_pos": 50270483, "end_pos": 50271433, 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"Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516904", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516904", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF195", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF195", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376920", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T6I9", "url": 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"pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6I9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6I9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 6, "end_pos": 8 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6J1-1", "uniprot_ac": "A0AAA9T6J1", "uniprot_id": "A0AAA9T6J1_BOVIN", "mass": { "chemical_mass": 37769.0, "monoisotopic_mass": 37769.0 }, "refseq": {}, "gene_names": [ { "name": "FGL1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1" } ] } ], "protein_names": [ { "name": "Fibrinogen-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6J1", "database": "UniProtKB", "url": 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LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1#function" }, { "database": "UniProtKB", "id": "ARBA00094376", "url": "https://www.uniprot.org/uniprotkb/ARBA00094376#function" }, { "database": "UniProtKB", "id": "A0AAF6Z298", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z298#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FGL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1", "locus": { "chromosome": "27", "start_pos": 19406133, "end_pos": 19352369, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016177", "url": "https://www.ensembl.org/id/ENSBTAG00000016177" } ] } } ], "crossref": [ { "id": "A0AAA9T6J1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6J1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508090", "url": "https://www.ncbi.nlm.nih.gov/gene/508090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00147", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T6J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z298", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z298", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z298-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z298-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIFIKIESQEMLSETIVSEFPVYVLSSLISDTVKALENCLQEQARLRAQVYLLETRVKQQQVKISQLLHEKQVQLLDKGEENSVIDLGGKRQYADCSEIFNDGYKQSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRDWSDYENGFGNFVQKNGEYWLGNRNLHLLTTQGDYTLKIDLADFEKNSRYAQYKNFKVGDEKNSYDLHIGEYSGTAGDSLTGNFHPEVQWWASHQRMKFSTWDRDNDNYEGNCAKEDQSGWWFNRCHSANLNGFYHKGPYTAKTDNGIVWHTWHGWWYSLKSVVMKIRPNDFIPNIV", "length": 325, "header": "tr|A0AAA9T6J1-1|A0AAA9T6J1_BOVIN Isoform 1 of Fibrinogen-like protein 1 OS=Bos taurus OX=9913 GN=FGL1 PE=4 SV=1 CANONICAL=A0AAA9T6J1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6J1/entry#A0AAA9T6J1-1", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/A0AAA9T6M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKF8", "url": "https://www.uniprot.org/uniprotkb/E1BKF8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKF8-1", "url": "https://www.uniprot.org/uniprotkb/E1BKF8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRRRHCALCTYRCAHARKTQGACAALSAGALLGNICRRLWRGPGDMAAAAALARLAAAFLLLAAQVACEYGMVHVVSETGGPKGKDYCILYNPQWAHLPHDLSKASLLQVRDWTSSVLCSPADLPPKGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSKEALVPPGGNKTQYEEIGIPVALLSYRDMLDIFQTFGQAVRAALHAPKEPMLDYNMVIIFLMAVGTVALGGYWAGSRDVRKRYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCSMLVLLYFFYDQLVYVIIGIFCLASSTGLYSCLSPLVQRLPFCKCRVPDNSLPYFHKRPQVRTLLLALLCATVSVVWGIFRNEDQWAWILQDALGIAFCLYTLKTIRLPTFKACTLLLLVLFIYDVFFVFITPFLTKSGNSIMVEVATGPSDSATHEKLPMVLKVPRLNASPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFMALALMQRGQPALLYLVPCTLVTSCALALWRRELGVFWTGSGFAKDLPQSPWAHAPTDGPQQPANSWRRRGPNPSAGRADSRTVCAGGEARGRRAPPGTRTPRGSTRPLGLGEGADSAPRSGLDSRGPQLGALVWPMRTSSSSPPAAPRPPALLRARVAAKPPAGRGQRRARSASCAVVSWGGQSGTSAGGLGHAQFGAYPAAASPGAGAGEGVVLVRRAPG", "length": 727, "header": "tr|A0AAA9T6M5-1|A0AAA9T6M5_BOVIN Isoform 1 of Signal peptide peptidase-like 2B OS=Bos taurus OX=9913 GN=SPPL2B PE=3 SV=1 CANONICAL=A0AAA9T6M5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6M5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5/entry#A0AAA9T6M5-1", "sequence": { "sequence": "MRRRRHCALCTYRCAHARKTQGACAALSAGALLGNICRRLWRGPGDMAAAAALARLAAAFLLLAAQVACEYGMVHVVSETGGPKGKDYCILYNPQWAHLPHDLSKASLLQVRDWTSSVLCSPADLPPKGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSKEALVPPGGNKTQYEEIGIPVALLSYRDMLDIFQTFGQAVRAALHAPKEPMLDYNMVIIFLMAVGTVALGGYWAGSRDVRKRYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCSMLVLLYFFYDQLVYVIIGIFCLASSTGLYSCLSPLVQRLPFCKCRVPDNSLPYFHKRPQVRTLLLALLCATVSVVWGIFRNEDQWAWILQDALGIAFCLYTLKTIRLPTFKACTLLLLVLFIYDVFFVFITPFLTKSGNSIMVEVATGPSDSATHEKLPMVLKVPRLNASPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFMALALMQRGQPALLYLVPCTLVTSCALALWRRELGVFWTGSGFAKDLPQSPWAHAPTDGPQQPANSWRRRGPNPSAGRADSRTVCAGGEARGRRAPPGTRTPRGSTRPLGLGEGADSAPRSGLDSRGPQLGALVWPMRTSSSSPPAAPRPPALLRARVAAKPPAGRGQRRARSASCAVVSWGGQSGTSAGGLGHAQFGAYPAAASPGAGAGEGVVLVRRAPG", "length": 727, "header": "tr|A0AAA9T6M5-1|A0AAA9T6M5_BOVIN Isoform 1 of Signal peptide peptidase-like 2B OS=Bos taurus OX=9913 GN=SPPL2B PE=3 SV=1 CANONICAL=A0AAA9T6M5-1" }, "locus": { "chromosome": "7", "start_pos": 21239224, "end_pos": 21225483, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097085.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097085.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093544.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093544.1" } ] } }, { "isoform_ac": "A0AAA9TDX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5/entry#A0AAA9TDX2-1", "sequence": { "sequence": "MRRRRHCALCTYRCAHARKTQGACAALSAGALLGNICRRLWRGPGDMAAAAALARLAAAFLLLAAQVACEYGMVHVVSETGGPKGKDYCILYNPQWAHLPHDLSKASLLQVRDWTSSVLCSPADLPPKGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSKEALVPPGGNKTQYEEIGIPVALLSYRDMLDIFQTFGQAVRAALHAPKEPMLDYNMVIIFLMAVGTVALGGYWAGSRDVRKRYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCSMLVLLYFFYDQLVYVIIGIFCLASSTGLYSCLSPLVQRLPFCKCRVPDNSLPYFHKRPQVRTLLLALLCATVSVVWGIFRNEDQWAWILQDALGIAFCLYTLKTIRLPTFKSGNSIMVEVATGPSDSATHEKLPMVLKVPRLNASPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFMALALMQRGQPALLYLVPCTLVTSCALALWRRELGVFWTGSGFAKDLPQSPWAHAPTDGPQQPHADPDAAPAPVPGRQTPGEDAVPTPPPAEQTPEQSAPEEKLGADAPLQEPERLAAPPGPSA", "length": 604, "header": "tr|A0AAA9TDX2-1|A0AAA9TDX2_BOVIN Computationally mapped isoform of Signal peptide peptidase-like 2B OS=Bos taurus OX=9913 GN=SPPL2B PE=3 SV=1 CANONICAL=A0AAA9T6M5-1" }, "locus": { "chromosome": "7", "start_pos": 21239224, "end_pos": 21225818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112250.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112250.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096808.1" } ] } }, { "isoform_ac": "A0AAA9TQS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5/entry#A0AAA9TQS3-1", "sequence": { "sequence": "MRERRRAPARRSAPGRCWETSADACGGDRATWRRRRRWRGSQRPSFSSRPRWPVSMAWCMWCLRPVAPKAKTTASSTTRSGPTCRMTSAKRLSCRCGTGPAPCSALPPTSPQKASATRSRWWHGGTAPSTRKCGWPRAVGPEGCSSSARRRWSPREATRRNMRRSAFPWPCSATETCWTFSRRYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCSMLVLLYFFYDQLVYVIIGIFCLASSTGLYSCLSPLVQRLPFCKCRVPDNSLPYFHKRPQVRTLLLALLCATVSVVWGIFRNEDQWAWILQDALGIAFCLYTLKTIRLPTFKACTLLLLVLFIYDVFFVFITPFLTKSGNSIMVEVATGPSDSATHEKLPMVLKVPRLNASPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFMALALMQRGQPALLYLVPCTLVTSCALALWRRELGVFWTGSGFAKDLPQSPWAHAPTDGPQQPHADPDAAPAPVPGRQTPGEDAVPTPPPAEQTPEQSAPEEKLGADAPLQEPERLAAPPGPSA", "length": 567, "header": "tr|A0AAA9TQS3-1|A0AAA9TQS3_BOVIN Computationally mapped isoform of Signal peptide peptidase like 2B OS=Bos taurus OX=9913 GN=SPPL2B PE=3 SV=1 CANONICAL=A0AAA9T6M5-1" }, "locus": { "chromosome": "7", "start_pos": 21239178, "end_pos": 21225818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131083.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131083.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100934.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100934.1" } ] } }, { "isoform_ac": "E1BKF8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5/entry#E1BKF8-1", "sequence": { "sequence": "MRRRRHCALCTYRCAHARKTQGACAALSAGALLGNICRRLWRGPGDMAAAAALARLAAAFLLLAAQVACEYGMVHVVSETGGPKGKDYCILYNPQWAHLPHDLSKASLLQVRDWTSSVLCSPADLPPKGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSKEALVPPGGNKTQYEEIGIPVALLSYRDMLDIFQTFGQAVRAALHAPKEPMLDYNMVIIFLMAVGTVALGGYWAGSRDVRKRYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCSMLVLLYFFYDQLVYVIIGIFCLASSTGLYSCLSPLVQRLPFCKCRVPDNSLPYFHKRPQVRTLLLALLCATVSVVWGIFRNEDQWAWILQDALGIAFCLYTLKTIRLPTFKACTLLLLVLFIYDVFFVFITPFLTKSGNSIMVEVATGPSDSATHEKLPMVLKVPRLNASPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFMALALMQRGQPALLYLVPCTLVTSCALALWRRELGVFWTGSGFADLPQSPWAHAPTDGPQQPHADPDAAPAPVPGRQTPGEDAVPTPPPAEQTPEQSAPEEKLGADAPLQEPERLAAPPGPSA", "length": 628, "header": "tr|E1BKF8-1|E1BKF8_BOVIN Computationally mapped isoform of Signal peptide peptidase-like 2B OS=Bos taurus OX=9913 GN=SPPL2B PE=3 SV=3 CANONICAL=A0AAA9T6M5-1" }, "locus": { "chromosome": "7", "start_pos": 21239224, "end_pos": 21225818, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035792.6", "url": "https://www.ensembl.org/id/ENSBTAT00000035792.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035660.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035660.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5357905", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytoplasmic side of endoplasmic reticulum membrane", "id": "GO:0098554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "Golgi-associated vesicle membrane", "id": "GO:0030660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030660", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "lumenal side of endoplasmic reticulum membrane", "id": "GO:0098553", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098553", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "organelle membrane", "id": "GO:0031090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "membrane protein ectodomain proteolysis", "id": "GO:0006509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "regulation of immune response", "id": "GO:0050776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "membrane protein intracellular domain proteolysis", "id": "GO:0031293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031293", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "membrane protein proteolysis", "id": "GO:0033619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033619", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" }, { "name": "aspartic endopeptidase activity, intramembrane cleaving", "id": "GO:0042500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042500", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6M5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M5" }, { "id": "PF02225", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PA", "eco_id": "ECO_0000259", "start_pos": 119, "end_pos": 194, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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{ "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", 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"https://www.uniprot.org/uniprotkb/A0AAA9T7D1/entry#A0AAA9T7D1-1", "sequence": { "sequence": "MEAEPAPDFAMLRELLAPPCLNPEPPPEPPIRQAPRTPGCLRPSGRSFWPAHQDSVTALRFLQETAEELAQTPWDTQALGPYWEPKALETLGPLPQAKDDKNMLTLVSQQSPNLGSPRAPPTSPAQPQRRPRKQSNPQRGAEKVDPLFEGVTLKFQIKPDSSLQIIPSYSLACSSRSPGPPTPGPARGPEANPGGSEALAPRRCASCRTERTPLWRDAEDGTPLCNACGIRYKKYGTRCSSCWLVPRKNVQPKKLCGRCGVSLGPHPASAQEGDLRWKTQASRPQSSWLGGSLAPSLAPASIRLG", "length": 305, "header": "tr|A0AAA9T7D1-1|A0AAA9T7D1_BOVIN Isoform 1 of Zinc finger GATA like protein 1 OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9T7D1-1" }, "locus": { "chromosome": "7", "start_pos": 14841025, "end_pos": 14838009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089165.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089165.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093829.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093829.1" } ] } }, { "isoform_ac": "E1BAH4-1", "url": 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"https://www.uniprot.org/uniprotkb/F6QNR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVILAAISTYPVYARHFTSAVAQAWTVRNEMHFGPALEGVGYSLGLDDLSISAVELTVHVGDSALLGCVSQSTGEKHVTKVDWMFSSGKHIEDEYVLFYYSNISVPVGHFQNRVRLVGDILHHDGSLLLQNVEETDQGNFTCEIRFQMESLVFKKVVVLHVLPEEPKELMVHVGDSTQMRCVFHSTEEKHMSRADWMFSSGEPAKEEIVLRYQRKLRTPMGYSQNWGRFLNRVNLVGDTSRNDVSIMLHGVKESDGGNYTCHIYLGNLTFRKTTVLQVILKESRTLVTPVALRPEILGGNQLVIIVGIVCATILLLPVLILIVKMAYGNKSSVTSTTLVKSLENTEKACAEKHIYSSITTQEVNDEEESSGKSEATYMTMNPVWPSLRSAPISPPDQRSTWGMAKTEQAF", "length": 410, "header": "tr|A0AAA9T7J0-1|A0AAA9T7J0_BOVIN Isoform 1 of Junction adhesion molecule like OS=Bos taurus OX=9913 GN=JAML PE=4 SV=1 CANONICAL=A0AAA9T7J0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7J0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0/entry#A0AAA9T7J0-1", "sequence": { "sequence": "MVILAAISTYPVYARHFTSAVAQAWTVRNEMHFGPALEGVGYSLGLDDLSISAVELTVHVGDSALLGCVSQSTGEKHVTKVDWMFSSGKHIEDEYVLFYYSNISVPVGHFQNRVRLVGDILHHDGSLLLQNVEETDQGNFTCEIRFQMESLVFKKVVVLHVLPEEPKELMVHVGDSTQMRCVFHSTEEKHMSRADWMFSSGEPAKEEIVLRYQRKLRTPMGYSQNWGRFLNRVNLVGDTSRNDVSIMLHGVKESDGGNYTCHIYLGNLTFRKTTVLQVILKESRTLVTPVALRPEILGGNQLVIIVGIVCATILLLPVLILIVKMAYGNKSSVTSTTLVKSLENTEKACAEKHIYSSITTQEVNDEEESSGKSEATYMTMNPVWPSLRSAPISPPDQRSTWGMAKTEQAF", "length": 410, "header": "tr|A0AAA9T7J0-1|A0AAA9T7J0_BOVIN Isoform 1 of Junction adhesion molecule like OS=Bos taurus OX=9913 GN=JAML PE=4 SV=1 CANONICAL=A0AAA9T7J0-1" }, "locus": { "chromosome": "15", "start_pos": 28910304, "end_pos": 28881944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114933.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114933.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092734.1" } ] } }, { "isoform_ac": "A0AAA9U1Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0/entry#A0AAA9U1Z1-1", "sequence": { "sequence": "MFYPLKVILIPVLLGYSLGLDDLSISAVELTVHVGDSALLGCVSQSTGEKHVTKVDWMFSSGKHIEDEYVLFYYSNISVPVGHFQNRVRLVGDILHHDGSLLLQNVEETDQGNFTCEIRFQMESLVFKKVVVLHVLPEEPKELMVHVGDSTQMRCVFHSTEEKHMSRADWMFSSGEPAKEEIVLRYQRKLRTPMGYSQNWGRFLNRVNLVGDTSRNDVSIMLHGVKESDGGNYTCHIYLGNLTFRKTTVLQVILKESRTLVTPVALRPEILGGNQLVIIVGIVCATILLLPVLILIVKMAYGNKSSVTSTTLVKSLENTEKACAEKHIYSSITTQEVNDEEESSGKSEATYMTMDDGLCCFPVTPAPRTHDSQMTAAEKGSARAD", "length": 385, "header": "tr|A0AAA9U1Z1-1|A0AAA9U1Z1_BOVIN Computationally mapped isoform of Junction adhesion molecule like OS=Bos taurus OX=9913 GN=JAML PE=4 SV=1 CANONICAL=A0AAA9T7J0-1" }, "locus": { "chromosome": "15", "start_pos": 28908121, "end_pos": 28883114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093496.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093496.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103935.1" } ] } }, { "isoform_ac": "F6QNR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0/entry#F6QNR7-1", "sequence": { "sequence": "MFYPLKVILIPVLLGYSLGLDDLSISAVELTVHVGDSALLGCVSQSTGEKHVTKVDWMFSSGKHIEDEYVLFYYSNISVPVGHFQNRVRLVGDILHHDGSLLLQNVEETDQGNFTCEIRFQMESLVFKKVVVLHVLPEEPKELMVHVGDSTQMRCVFHSTEEKHMSRADWMFSSGEPAKEEIVLRYQRKLRTPMGYSQNWGRFLNRVNLVGDTSRNDVSIMLHGVKESDGGNYTCHIYLGNLTFRKTTVLQVILKESRTLVTPVALRPEILGGNQLVIIVGIVCATILLLPVLILIVKMAYGNKSSVTSTTLVKSLENTEKACAEVREEFCHSRSCDSKHIYSSITTQEVNDEEESSGKSEATYMTMNPVWPSLRSAPISPPDQRSTWGMAKTEQAF", "length": 397, "header": "tr|F6QNR7-1|F6QNR7_BOVIN Computationally mapped isoform of Junction adhesion molecule like OS=Bos taurus OX=9913 GN=JAML PE=4 SV=1 CANONICAL=A0AAA9T7J0-1" }, "locus": { "chromosome": "15", "start_pos": 28908121, "end_pos": 28881944, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021233.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021233.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021233.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021233.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "neutrophil chemotaxis", "id": "GO:0030593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "neutrophil extravasation", "id": "GO:0072672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" }, { "name": "monocyte extravasation", "id": "GO:0035696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035696", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 139, "end_pos": 141, "annotation": "n_glycosylation_sequon" }, { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 152, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 139, "end_pos": 141 }, { "start_pos": 258, "end_pos": 260 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 329, "end_pos": 331 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7J6-1", "uniprot_ac": "A0AAA9T7J6", "uniprot_id": "A0AAA9T7J6_BOVIN", "mass": { "chemical_mass": 83166.0, "monoisotopic_mass": 83166.0 }, "refseq": {}, "gene_names": [ { "name": "TNFAIP2", "type": "recommended", "evidence": [ { "id": "A0AAA9T7J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ] } ], "protein_names": [ { "name": "Tumor necrosis factor alpha-induced protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9T7J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6/entry#names_and_taxonomy" } ] }, { "name": "Primary response gene B94 protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T7J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role as a mediator of inflammation and angiogenesis.", "evidence": [ { "database": "UniProtKB", "id": "E1BJZ6", "url": "https://www.uniprot.org/uniprotkb/E1BJZ6#function" }, { "database": "UniProtKB", "id": "ARBA00054749", "url": "https://www.uniprot.org/uniprotkb/ARBA00054749#function" }, { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFAIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6", "locus": { "chromosome": "21", "start_pos": 67826211, "end_pos": 67811384, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035995", "url": "https://www.ensembl.org/id/ENSBTAG00000035995" } ] } } ], "crossref": [ { "id": "A0AAA9T7J6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7J6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035995", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035995", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786672", "url": "https://www.ncbi.nlm.nih.gov/gene/786672", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJZ6", "url": "https://www.orthodb.org/?gene=E1BJZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21292:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21292:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJZ6", "url": "https://www.uniprot.org/uniprotkb/E1BJZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJZ6-1", "url": "https://www.uniprot.org/uniprotkb/E1BJZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPWLQPGARPCPAASFQVSRVPLHRSWPGSPHGQGAGEGAASLDGGEAQFLARVGVMLKMLTFFQGLPGQQPVSGAPDFPRSAQKLPSTSEAESEASMSEASSEDLVPSLEAEVATDRDEEEAGKKKKKSKGLATMISVFTKGRKKKGQPSLSETEGESESSPRPPAQLPTVEELKADLERGRLEAARPLLALELELQEAAAAGRASEEELVRRQSKVEALYALLRDQVLGQLRRPLEAEPERLRQALAVLAEQERQDHAAAAAGPPGCPGLATTRPRGWLQLWRDGVAQAAAERLSRRPAADAEGRTEAERTFLHMGRTMKEDLEAVVERLKPLFPADIRVVAAYAESYHAEFASQLSALTQFELCQRDTYMLLLWVQNLYPNDILNSPKLAPELQGVRLGTLLPPTQIRLLEATFLSNEVASVRELTARALELESNRWTNDEAPQRLDGHCHSELAIDIIQIISQGQAKAESITLDLGAQIKPLLLEELARFLRSYQHAFDGFLERCRQLRNYRANVIANINNCLPFRTSLEQQWQTPPDLRSSLLRPLNELKSHGFDTLLQSLFGDLKPLFKRFTQTRWAAPQQTLEEIVSAVAERMPEFSELQDCFREELLEAVHLHLVKEYIARLCKRRLVLKTAEQQQQLAGHVQANAQLIQQFCTQSGSRATWLHDALPTLAEIIRLQDPSAIKIEVATYSTLYPDFSKGHLSAILAIKGNLSSSDAKSIRSILDINTGAHEPSKALFSLIKVG", "length": 751, "header": "tr|A0AAA9T7J6-1|A0AAA9T7J6_BOVIN Isoform 1 of Tumor necrosis factor alpha-induced protein 2 OS=Bos taurus OX=9913 GN=TNFAIP2 PE=3 SV=1 CANONICAL=A0AAA9T7J6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7J6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6/entry#A0AAA9T7J6-1", "sequence": { "sequence": "MPWLQPGARPCPAASFQVSRVPLHRSWPGSPHGQGAGEGAASLDGGEAQFLARVGVMLKMLTFFQGLPGQQPVSGAPDFPRSAQKLPSTSEAESEASMSEASSEDLVPSLEAEVATDRDEEEAGKKKKKSKGLATMISVFTKGRKKKGQPSLSETEGESESSPRPPAQLPTVEELKADLERGRLEAARPLLALELELQEAAAAGRASEEELVRRQSKVEALYALLRDQVLGQLRRPLEAEPERLRQALAVLAEQERQDHAAAAAGPPGCPGLATTRPRGWLQLWRDGVAQAAAERLSRRPAADAEGRTEAERTFLHMGRTMKEDLEAVVERLKPLFPADIRVVAAYAESYHAEFASQLSALTQFELCQRDTYMLLLWVQNLYPNDILNSPKLAPELQGVRLGTLLPPTQIRLLEATFLSNEVASVRELTARALELESNRWTNDEAPQRLDGHCHSELAIDIIQIISQGQAKAESITLDLGAQIKPLLLEELARFLRSYQHAFDGFLERCRQLRNYRANVIANINNCLPFRTSLEQQWQTPPDLRSSLLRPLNELKSHGFDTLLQSLFGDLKPLFKRFTQTRWAAPQQTLEEIVSAVAERMPEFSELQDCFREELLEAVHLHLVKEYIARLCKRRLVLKTAEQQQQLAGHVQANAQLIQQFCTQSGSRATWLHDALPTLAEIIRLQDPSAIKIEVATYSTLYPDFSKGHLSAILAIKGNLSSSDAKSIRSILDINTGAHEPSKALFSLIKVG", "length": 751, "header": "tr|A0AAA9T7J6-1|A0AAA9T7J6_BOVIN Isoform 1 of Tumor necrosis factor alpha-induced protein 2 OS=Bos taurus OX=9913 GN=TNFAIP2 PE=3 SV=1 CANONICAL=A0AAA9T7J6-1" }, "locus": { "chromosome": "21", "start_pos": 67825545, "end_pos": 67811399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093901.1" } ] } }, { "isoform_ac": "E1BJZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6/entry#E1BJZ6-1", "sequence": { "sequence": "MLKMLTFFQGLPGQQPVSGAPDFPRSAQKLPSTSEAESEASMSEASSEDLVPSLEAEVATDRDEEEAGKKKKKSKGLATMISVFTKGRKKKGQPSLSETEGESESSPRPPAQLPTVEELKADLERGRLEAARPLLALELELQEAAAAGRASEEELVRRQSKVEALYALLRDQVLGQLRRPLEAEPERLRQALAVLAEQERQDHAAAAAGPPGCPGLATTRPRGWLQLWRDGVAQAAAERLSRRPAADAEGRTEAERTFLHMGRTMKEDLEAVVERLKPLFPADIRVVAAYAESYHAEFASQLSALTQFELCQRDTYMLLLWVQNLYPNDILNSPKLAPELQGVRLGTLLPPTQIRLLEATFLSNEVASVRELTARALELESNRWTNDEAPQRLDGHCHSELAIDIIQIISQGQAKAESITLDLGAQIKPLLLEELARFLRSYQHAFDGFLERCRQLRNYRANVIANINNCLPFRTSLEQQWQTPPDLRSSLLRPLNELKSHGFDTLLQSLFGDLKPLFKRFTQTRWAAPQQTLEEIVSAVAERMPEFSELQDCFREELLEAVHLHLVKEYIARLCKRRLVLKTAEQQQQLAGHVQANAQLIQQFCTQSGSRATWLHDALPTLAEIIRLQDPSAIKIEVATYSTLYPDFSKGHLSAILAIKGNLSSSDAKSIRSILDINTGAHEPSKALFSLIKVG", "length": 695, "header": "tr|E1BJZ6-1|A0AAA9T7J6_BOVIN Computationally mapped isoform of Tumor necrosis factor alpha-induced protein 2 OS=Bos taurus OX=9913 GN=TNFAIP2 PE=3 SV=4 CANONICAL=A0AAA9T7J6-1" }, "locus": { "chromosome": "21", "start_pos": 67825545, "end_pos": 67816065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050485.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050485.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047178.5", "url": "https://www.ensembl.org/id/ENSBTAP00000047178.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" }, { "name": "exocyst localization", "id": "GO:0051601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051601", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 718, "end_pos": 720 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7J9-1", "uniprot_ac": "A0AAA9T7J9", "uniprot_id": "A0AAA9T7J9_BOVIN", "mass": { "chemical_mass": 50174.0, "monoisotopic_mass": 50174.0 }, "refseq": {}, "gene_names": [ { "name": "NFS1", "type": "recommended", "evidence": [ { "id": "A0AAA9T7J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ] } ], "protein_names": [ { "name": "cysteine desulfurase", "type": "recommended", "evidence": [ { "id": "A0AAA9T7J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9/entry#names_and_taxonomy" } ] }, { "name": "2.8.1.7", "type": "synonym", "evidence": [ { "id": "A0AAA9T7J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9", "locus": { "chromosome": "13", "start_pos": 64887674, "end_pos": 64905085, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006962", "url": "https://www.ensembl.org/id/ENSBTAG00000006962" } ] } } ], "crossref": [ { "id": "A0AAA9T7J9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7J9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000192", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000192", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11601", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11601", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11601:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11601:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17457", "url": "https://www.rhea-db.org/rhea/17457", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMF1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLRTAWRRVATAAPAAPGPRAKPPIRGLRLRDLTPQSAVASDAAIALEAESVLRPLYMDVQATTPLDPRVLDAMLPYLVNYYGNPHSRTHAYGWESEAAMECARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFKVTYLPVKKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIKEIGQICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLAERLIQKIMKSLPDVVMNGDPEHHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH", "length": 455, "header": "tr|A0AAA9T7J9-1|A0AAA9T7J9_BOVIN Isoform 1 of cysteine desulfurase OS=Bos taurus OX=9913 GN=NFS1 PE=3 SV=1 CANONICAL=A0AAA9T7J9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9/entry#A0AAA9T7J9-1", "sequence": { "sequence": "MLLRTAWRRVATAAPAAPGPRAKPPIRGLRLRDLTPQSAVASDAAIALEAESVLRPLYMDVQATTPLDPRVLDAMLPYLVNYYGNPHSRTHAYGWESEAAMECARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFKVTYLPVKKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIKEIGQICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLAERLIQKIMKSLPDVVMNGDPEHHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH", "length": 455, "header": "tr|A0AAA9T7J9-1|A0AAA9T7J9_BOVIN Isoform 1 of cysteine desulfurase OS=Bos taurus OX=9913 GN=NFS1 PE=3 SV=1 CANONICAL=A0AAA9T7J9-1" }, "locus": { "chromosome": "13", "start_pos": 64904886, "end_pos": 64888348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120414.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120414.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092745.1" } ] } }, { "isoform_ac": "A0AAA9TR03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9/entry#A0AAA9TR03-1", "sequence": { "sequence": "MLLRTAWRRVATAAPAAPGPRAKPPIRGLRLRGIDLTPQSAVASDAAIALEAESVLRPLYMDVQATTPLDPRVLDAMLPYLVNYYGNPHSRTHAYGWESEAAMECARQQVASLIGADPREIIFTSGATESNNIAIKELEAAIQPDTSLVSVMTVNNEIGVKQPIKEIGQICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLAERLIQKIMKSLPDVVMNGDPEHHYPGCINLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVDYTVEKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH", "length": 406, "header": "tr|A0AAA9TR03-1|A0AAA9TR03_BOVIN Computationally mapped isoform of cysteine desulfurase OS=Bos taurus OX=9913 GN=NFS1 PE=3 SV=1 CANONICAL=A0AAA9T7J9-1" }, "locus": { "chromosome": "13", "start_pos": 64904886, "end_pos": 64888348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091426.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091426.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098864.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098864.1" } ] } }, { "isoform_ac": "A0AAF6DMF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9/entry#A0AAF6DMF1-1", "sequence": { "sequence": "MLLRTAWRRVATAAPAAPGPRAKPPIRGLRLRGIDLTPQSAVASDAAIALEAESVLRPLYMDVQATTPLDPRVLDAMLPYLVNYYGNPHSRTHAYGWESEAAMECARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFKVTYLPVKKSGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIKEIGQICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLGAACEVAQQEMEYDHKRISKLAERLIQKIMKSLPDVVMNGDPEHHYPGCINLSFAYVEGESLLMALKDVALSSGRFGIGRFTTEEEVDYTVEKCIHHVKRLREMSPLWEMVQDGIDLKSIKWTQH", "length": 429, "header": "tr|A0AAF6DMF1-1|A0AAF6DMF1_BOVIN Computationally mapped isoform of cysteine desulfurase OS=Bos taurus OX=9913 GN=NFS1 PE=3 SV=1 CANONICAL=A0AAA9T7J9-1" }, "locus": { "chromosome": "13", "start_pos": 64904886, "end_pos": 64888348, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009149.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009149.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009149.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009149.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "mitochondrial [2Fe-2S] assembly complex", "id": "GO:0099128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099128", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "iron-sulfur cluster binding", "id": "GO:0051536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051536", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "cysteine desulfurase activity", "id": "GO:0031071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031071", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" }, { "name": "sulfur carrier activity", "id": "GO:0097163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7J9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7J9" } ], "pmid": "" } ] }, { "name": "Biological Process", 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"crossref": [ { "id": "A0AAA9T7L8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7L8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045946", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045946", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00220", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00220", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526730", "url": "https://www.ncbi.nlm.nih.gov/gene/526730", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005515", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005515", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526730", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526730", "database": "KEGG Pathway", 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"MRLAPRGQQRAQPQLHRHLPGADSYMSVIEVTNGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIPGDDTALNGIRLHCARGQADLNAHVVESQSGRWGWWSEPLWCPVGGFLVAFSLRVEAPVTFGDNTAANNVRFLCSDGTELQGPGLTWGDFGNWSELCPKGICGLQTKIQQPQGLLDDTAINDALFFCCRN", "length": 195, "header": "tr|G3MX66-1|G3MX66_BOVIN Computationally mapped isoform of Vitelline membrane outer layer protein 1 homolog OS=Bos taurus OX=9913 GN=VMO1 PE=3 SV=3 CANONICAL=A0AAA9T7L8-1" }, "locus": { "chromosome": "19", "start_pos": 26575671, "end_pos": 26571143, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064861.3", "url": "https://www.ensembl.org/id/ENSBTAT00000064861.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054126.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054126.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526730", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526730", "resource": "KEGG Pathway" } ], 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH55", "url": "https://www.uniprot.org/uniprotkb/F1MH55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH55-1", "url": "https://www.uniprot.org/uniprotkb/F1MH55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVKLLSRVQLLAIPWTAAYQAPLSIGFASSAFSGSVHSQKEEEMNEFQDTVTFKDVAIDFTQEEWKQLDPAQRNLYRNVMLENYNNLITVGCPFTKPDVIFKLEQEEEPWVMEEEVLKKHCPGEIWGMDEQLKIQDRLLTQLEDKFTKTLTDEKVSECHKKFANAFPLNSDFFPSSHSVYEYDLFGKCLEHNNLNYCERIFIGREDCEYKEPMKSFGNSLSHLVVTPFKCNHCGKGFDQTLDLIRHLRIHTGEKPYECKKCRKAFGHKEKLIKHHKIHSREQSYECNECGKAFIKMSNLIRHQRIHTGEKPYACKECGKSFSQKSNLIDHEKIHTGEKPYECHECGKAFSQKQSLIAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKSFSQSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCNECGKAFSQKSHLVRHQRIHTY", "length": 729, "header": "tr|A0AAA9T7M2-1|A0AAA9T7M2_BOVIN Isoform 1 of Zinc finger protein 569 OS=Bos taurus OX=9913 GN=ZNF569 PE=3 SV=1 CANONICAL=A0AAA9T7M2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7M2-1", "url": 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{ "chromosome": "18", "start_pos": 47438665, "end_pos": 47417828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095426.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095426.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094734.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094734.1" } ] } }, { "isoform_ac": "A0AAA9TYQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2/entry#A0AAA9TYQ0-1", "sequence": { "sequence": "MNEFQDTVTFKDVAIDFTQEEWKQLDPAQRNLYRNVMLENYNNLITVGCPFTKPDVIFKLEQEEEPWVMEEEVLKKHCPGEIWGMDEQLKIQDRLLTQLEDKFTKTLTDEKVSECHKKFANAFPLNSDFFPSSHSVYEYDLFGKCLEHNNLNYCERIFIGREDCEYKEPMKSFGNSLSHLVVTPFKCNHCGKGFDQTLDLIRHLRIHTGEKPYECKKCRKAFGHKEKLIKHHKIHSREQSYECNECGKAFIKMSNLIRHQRIHTGEKPYACKECGKSFSQKSNLIDHEKIHTGEKPYECHECGKAFSQKQSLIAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKSFSQSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCNECGKAFSQKSHLVRHQRIHTY", "length": 657, "header": "tr|A0AAA9TYQ0-1|A0AAA9TYQ0_BOVIN Computationally mapped isoform of Zinc finger protein 569 OS=Bos taurus OX=9913 GN=ZNF569 PE=3 SV=1 CANONICAL=A0AAA9T7M2-1" }, "locus": { "chromosome": "18", "start_pos": 47435661, "end_pos": 47417828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": 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"MLHVTGVKRCLGYSIEQSRQTLLSCSAFSGSVHSQKEEEMNEFQDTVTFKDVAIDFTQEEWKQLDPAQRNLYRNVMLENYNNLITVGCPFTKPDVIFKLEQEEEPWVMEEEVLKKHCPGEIWGMDEQLKIQDRLLTQLEDKFTKTLTDEKVSECHKKFANAFPLNSDFFPSSHSVYEYDLFGKCLEHNNLNYCERIFIGREDCEYKEPMKSFGNSLSHLVVTPFKCNHCGKGFDQTLDLIRHLRIHTGEKPYECKKCRKAFGHKEKLIKHHKIHSREQSYECNECGKAFIKMSNLIRHQRIHTGEKPYACKECGKSFSQKSNLIDHEKIHTGEKPYECHECGKAFSQKQSLIAHQKVHTGEKPYACNECGKAFPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKSFSQSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQMSNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCNECGKAFSQKSHLVRHQRIHTY", "length": 724, "header": "tr|F1MH55-1|A0AAA9T7M2_BOVIN Computationally mapped isoform of Zinc finger protein 569 OS=Bos taurus OX=9913 GN=ZNF569 PE=3 SV=4 CANONICAL=A0AAA9T7M2-1" }, "locus": { "chromosome": "18", "start_pos": 47439169, "end_pos": 47417828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031518.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031518.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031471.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031471.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 229, "end_pos": 256, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T7M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7M2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 123, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], 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"go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U4" }, { 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"glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL13RA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V6", "locus": { "chromosome": "X", "start_pos": 3246931, "end_pos": 3168074, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019338", "url": "https://www.ensembl.org/id/ENSBTAG00000019338" } ] } } ], "crossref": [ { "id": "A0AAA9T7V6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7V6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019338", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019338", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": 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[ "Protein Classification" ] }, { "id": "PTHR23037:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23037:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6785807", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7V6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7V6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TID8", "url": 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"MQGGMDLSVLPNNNHPDKFLQLDVKSLMRNSALLQASLVRFPGGNYPAAQHWQNLVYSQREKKNITAQHVRGSSVKGTITVESPPPSLSSVLKNNPLYGDVSFEEAMEERKKNPSWTAEEYDKRSLHTNLSGHLKVLKENPNDLRFWLGEMYTPGFDTLLKKEEEQEKHSKYRRVGLILLLVACVLVSIVTVSTFFI", "length": 197, "header": "tr|A0AAA9T874-1|A0AAA9T874_BOVIN Isoform 1 of Membrane integral NOTCH2 associated receptor 2 OS=Bos taurus OX=9913 GN=MINAR2 PE=3 SV=1 CANONICAL=A0AAA9T874-1" }, "locus": { "chromosome": "7", "start_pos": 24399648, "end_pos": 24385788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135949.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135949.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094157.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094157.1" } ] } }, { "isoform_ac": "G3MZ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874/entry#G3MZ28-1", "sequence": { "sequence": "MRRNKILHITCEAVETRPIQLGQLSSVQREVSINASLQMQGGMDLSVLPNNNHPDKFLQLDVKSLMRNSALLQASLVRFPGGNYPAAQHWQNLVYSQREKKNITAQHVRGSSVKGTITVESPPPSLSSVLKNNPLYGDVSFEEAMEERKKNPSWTAEEYDKRSLHTNLSGHLKVLKENPNDLRFWLGEMYTPGFDTLLKKEEEQEKHSKYRRVGLILLLVACVLVSIVTVSTFFI", "length": 235, "header": "tr|G3MZ28-1|G3MZ28_BOVIN Computationally mapped isoform of Membrane integral NOTCH2 associated receptor 2 OS=Bos taurus OX=9913 GN=MINAR2 PE=3 SV=3 CANONICAL=A0AAA9T874-1" }, "locus": { "chromosome": "7", "start_pos": 24400141, "end_pos": 24385788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063180.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063180.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054819.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054819.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" }, { "name": "stereocilium", "id": "GO:0032420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032420", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T874", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T874" }, { "id": "PF06789", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06789" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major intrinsically disordered Notch2-binding receptor 1-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 51, "end_pos": 193, "start_aa": "His", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 64, "end_pos": 66 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T877-1", "uniprot_ac": "A0AAA9T877", "uniprot_id": "A0AAA9T877_BOVIN", "mass": { "chemical_mass": 53151.0, "monoisotopic_mass": 53151.0 }, "refseq": { "ac": "XP_002686423", "name": "probable proline--tRNA ligase, mitochondrial", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686423" }, "gene_names": [ { "name": "PARS2", "type": "recommended", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ] }, { "name": "PARS2", "type": "synonym", "evidence": [ { "id": "XP_002686423", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686423" } ] } ], "protein_names": [ { "name": "Probable proline--tRNA ligase, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.15", "type": "synonym", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877/entry#names_and_taxonomy" } ] }, { "name": "Prolyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877/entry#names_and_taxonomy" } ] }, { "name": "probable proline--tRNA ligase, mitochondrial", "type": "synonym", "evidence": [ { "id": "XP_002686423", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686423" } ] } ], "function": [ { "annotation": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877#function" }, { "database": "UniProtKB", "id": "ARBA00058798", "url": "https://www.uniprot.org/uniprotkb/ARBA00058798#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PARS2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877", "locus": { "chromosome": "3", "start_pos": 91534420, "end_pos": 91528169, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055903", "url": "https://www.ensembl.org/id/ENSBTAG00000055903" } ] } } ], "crossref": [ { "id": "cd00779", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00779", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508907", "url": "https://www.ncbi.nlm.nih.gov/gene/508907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR42753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42753:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42753:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00587", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00587", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686423", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686423", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14305", "url": "https://www.rhea-db.org/rhea/14305", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T877-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGLLTRCRALPALATCSHQLSQYAPQRFHHCAPGRGKRLMLSRMFQPQKLREDQVLSLEGRSGDLTCKSQRLMLQMGLIHPASPGCYHLLPYTVRAMEKLVRVIDQEMQTIGGQKVNMPSLSPAELWRATKRWDSMGRELLRLRDRHGKDYCLGPTHEEAITALVASQKTLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQLTYSLVCDAYSSLFNRLGLRCIKVQADVGSIGGMVSHEFQLPVDVGEDRLVVCPSCHFSANMETLDSSRTNCPACQGPLTETKGIEVGHTFYLGTKYSSIFNAQFINVHGKPSLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPGLLAPYQVCLIPPKKGSKEEAAAELAGDLYNHITEAVPQLQGEVLLDDRTHLTIGNRLKDANKLGYPFVIIAAKRALDDPAHFEVWCQNTGEVVFLTREGVLELLSQVQVV", "length": 475, "header": "tr|A0AAA9T877-1|A0AAA9T877_BOVIN Isoform 1 of Probable proline--tRNA ligase, mitochondrial OS=Bos taurus OX=9913 GN=PARS2 PE=3 SV=1 CANONICAL=A0AAA9T877-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T877-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877/entry#A0AAA9T877-1", "sequence": { "sequence": "MEGLLTRCRALPALATCSHQLSQYAPQRFHHCAPGRGKRLMLSRMFQPQKLREDQVLSLEGRSGDLTCKSQRLMLQMGLIHPASPGCYHLLPYTVRAMEKLVRVIDQEMQTIGGQKVNMPSLSPAELWRATKRWDSMGRELLRLRDRHGKDYCLGPTHEEAITALVASQKTLSYKQLPFLLYQVTRKFRDEPRPRFGLLRGREFYMKDMYTFDSSPEAAQLTYSLVCDAYSSLFNRLGLRCIKVQADVGSIGGMVSHEFQLPVDVGEDRLVVCPSCHFSANMETLDSSRTNCPACQGPLTETKGIEVGHTFYLGTKYSSIFNAQFINVHGKPSLAEMGCYGLGVTRILAAAIEVLSTEDCVRWPGLLAPYQVCLIPPKKGSKEEAAAELAGDLYNHITEAVPQLQGEVLLDDRTHLTIGNRLKDANKLGYPFVIIAAKRALDDPAHFEVWCQNTGEVVFLTREGVLELLSQVQVV", "length": 475, "header": "tr|A0AAA9T877-1|A0AAA9T877_BOVIN Isoform 1 of Probable proline--tRNA ligase, mitochondrial OS=Bos taurus OX=9913 GN=PARS2 PE=3 SV=1 CANONICAL=A0AAA9T877-1" }, "locus": { "chromosome": "3", "start_pos": 91530800, "end_pos": 91529376, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103823.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103823.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092808.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:508907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508907", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "proline-tRNA ligase activity", "id": "GO:0004827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004827", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "prolyl-tRNA aminoacylation", "id": "GO:0006433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006433", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T877", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14305", "name": "", "equation": "tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T877-1", "A0AAA9TMZ2-1" ], "evidence": [ { "id": "14305", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14305" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T877", "gene_name": "PARS2", "activity": [ { "ec_number": "6.1.1.15", "activity": "tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate.", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ] }, { "ec_number": "6.1.1.15", "activity": "", "evidence": [ { "id": "A0AAA9T877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T877" } ] } ] }, { "uniprot_ac": "A0AAA9TMZ2", "gene_name": "EPRS1", "activity": [ { "ec_number": "6.1.1.15", "activity": "tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate.", "evidence": [ { "id": "A0AAA9TMZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMZ2" } ] }, { "ec_number": "6.1.1.17", "activity": "tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate.", "evidence": [ { 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Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. 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"database": "Ensembl Gene", "id": "ENSBTAG00000004448", "url": "https://www.ensembl.org/id/ENSBTAG00000004448" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004448", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004448", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533980", "url": "https://www.ncbi.nlm.nih.gov/gene/533980", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1B7K5", "url": "https://www.orthodb.org/?gene=E1B7K5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12348", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12348", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005216520", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216520", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T894", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T894", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T894-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T894-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7K5", "url": "https://www.uniprot.org/uniprotkb/E1B7K5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7K5-1", "url": "https://www.uniprot.org/uniprotkb/E1B7K5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDDSEWMKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGMEICLMYIEIEKGEAVQEELLKGLDNKNPKIVVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRDALRPPLQNINPVQLKELEEEWVKLPTGAPRPARFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALEAVEVLVKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELVHGKKAGLAADKKDFKPVPGRAAASGAAGDKDTKDASAPKPGPLKKAPAAKPGGPPKKGKPAAQGGTGGTGTKSKKAVETKEMVEPELSIEVCEEKASAVLPATCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEAMTAIAEACVLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTSAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQNPPAPTRGISKHSTSGTDEGEDGDEPDDGGSDAVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAAIINEAKFIQPNIGELPTALKGRLNDSNKILVQQTLTILQQLAVAMGPNIKQHVKNLGIPVITVLGDSKNNVRSAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCVPQLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPAKPTAPAKATSRPVGGSAPAKFQPASAPAEDSVSGTLDSKPDPKKAKALGVSSKTKTAQGKKVPSKTSLKEDDDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWVTLRFFDTNTSVLMKTLEYLKLLFTLLSDEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGTLSEKDMSMLEERIKRSAKRPSAAPVKQVEEKPQRTQSISSNTNMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDSGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVVRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRLPTSAGISPQMEVTCVPTATSTASSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTRSSGATTTSSSTANIDDLKKRLERIKSSRK", "length": 2031, "header": "tr|A0AAA9T894-1|A0AAA9T894_BOVIN Isoform 1 of Cytoskeleton-associated protein 5 OS=Bos taurus OX=9913 GN=CKAP5 PE=3 SV=1 CANONICAL=A0AAA9T894-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T894-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T894/entry#A0AAA9T894-1", "sequence": { "sequence": "MGDDSEWMKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGMEICLMYIEIEKGEAVQEELLKGLDNKNPKIVVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRDALRPPLQNINPVQLKELEEEWVKLPTGAPRPARFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALEAVEVLVKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELVHGKKAGLAADKKDFKPVPGRAAASGAAGDKDTKDASAPKPGPLKKAPAAKPGGPPKKGKPAAQGGTGGTGTKSKKAVETKEMVEPELSIEVCEEKASAVLPATCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEAMTAIAEACVLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTSAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQNPPAPTRGISKHSTSGTDEGEDGDEPDDGGSDAVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAAIINEAKFIQPNIGELPTALKGRLNDSNKILVQQTLTILQQLAVAMGPNIKQHVKNLGIPVITVLGDSKNNVRSAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCVPQLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPAKPTAPAKATSRPVGGSAPAKFQPASAPAEDSVSGTLDSKPDPKKAKALGVSSKTKTAQGKKVPSKTSLKEDDDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWVTLRFFDTNTSVLMKTLEYLKLLFTLLSDEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGTLSEKDMSMLEERIKRSAKRPSAAPVKQVEEKPQRTQSISSNTNMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDSGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVVRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRLPTSAGISPQMEVTCVPTATSTASSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTRSSGATTTSSSTANIDDLKKRLERIKSSRK", "length": 2031, "header": "tr|A0AAA9T894-1|A0AAA9T894_BOVIN Isoform 1 of Cytoskeleton-associated protein 5 OS=Bos taurus OX=9913 GN=CKAP5 PE=3 SV=1 CANONICAL=A0AAA9T894-1" }, "locus": { "chromosome": "15", "start_pos": 76739867, "end_pos": 76674734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116650.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116650.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092064.1" } ] } }, { "isoform_ac": "E1B7K5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T894/entry#E1B7K5-1", "sequence": { "sequence": "MGDDSEWMKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGMEICLMYIEIEKGEAVQEELLKGLDNKNPKIVVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAVRDEAKLIAVEIYRWIRDALRPPLQNINPVQLKELEEEWVKLPTGAPRPARFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALEAVEVLVKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHINDSAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELVHGKKAGLAADKKDFKPVPGRAAASGAAGDKDTKDASAPKPGPLKKAPAAKPGGPPKKGKPAAQGGTGGTGTKSKKAVETKEMVEPELSIEVCEEKASAVLPATCIQLLDSSNWKERLACMEEFQKAVELMDRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEAMTAIAEACVLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTSAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQNPPAPTRGISKHSTSGTDEGEDGDEPDDGGSDAVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAAIINEAKFIQPNIGELPTALKGRLNDSNKILVQQTLTILQQLAVAMGPNIKQHVKNLGIPVITVLGDSKNNVRSAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTLRSTPTDLILCVPQLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPAKPTAPAKATSRPVGGSAPAKFQPASAPAEDSVSGTLDSKPDPKKAKALGVSSKTKTAQGKKVPSKTSLKEDDDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWVTLRFFDTNTSVLMKTLEYLKLLFTLLSDEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHGDQVFKLIGTLSEKDMSMLEERIKRSAKRPSAAPVKQVEEKPQRTQSISSNTNMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEIENDSGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVVRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRLPTSAGISPQMEVTCVPTATSTASSLGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTRSSGATTTSSSTANIDDLKKRLERIKSSRK", "length": 1972, "header": "tr|E1B7K5-1|E1B7K5_BOVIN Computationally mapped isoform of Cytoskeleton-associated protein 5 OS=Bos taurus OX=9913 GN=CKAP5 PE=3 SV=3 CANONICAL=A0AAA9T894-1" }, "locus": { "chromosome": "15", "start_pos": 76739867, "end_pos": 76674734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005832.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005832.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005832.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005832.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1363, "start_aa": "Thr", "end_pos": 1363, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1363", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 821, "start_aa": "Thr", "end_pos": 821, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr821", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-8854518", "name": "", "url": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8E2-1", "uniprot_ac": "A0AAA9T8E2", "uniprot_id": "A0AAA9T8E2_BOVIN", "mass": { "chemical_mass": 254353.0, "monoisotopic_mass": 254353.0 }, "refseq": {}, "gene_names": [ { "name": "ABCA1", "type": "recommended", "evidence": [ { "id": "A0AAA9T8E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ] } ], "protein_names": [ { "name": "P-type phospholipid transporter", "type": "recommended", "evidence": [ { "id": "A0AAA9T8E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.1", "type": "synonym", "evidence": [ { "id": "A0AAA9T8E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2", "locus": { "chromosome": "8", "start_pos": 94602861, "end_pos": 94719841, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020661", "url": "https://www.ensembl.org/id/ENSBTAG00000020661" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020661", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020661", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535379", "url": "https://www.ncbi.nlm.nih.gov/gene/535379", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AWQDYIS", "url": "https://omabrowser.org/oma/group/AWQDYIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG24", "url": "https://www.orthodb.org/?gene=F1MG24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12698", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12698", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26955", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26955", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8963896", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963896", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9029569", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9029569", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG24", "url": "https://www.uniprot.org/uniprotkb/F1MG24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG24-1", "url": "https://www.uniprot.org/uniprotkb/F1MG24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYWPQLRLLLWKNLTFRRRQTCQLFLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDARRLLLYSHRDTSMKDIRKVLKTLYQIERFSSRLKLQDFLVDNETFSGFLHHNLSLPRPTVDKMLGADVSLRKVFLQGYQLHLSNLCNGSKLGEVIRLGDQEVSRFCSLPREKLNAAQQVLRSNLDILKPVLTKLNSTSLFPTEELGEATKALLDSLGNLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIICGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEDDAGTVYDNSTSPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPVTRRLMTEVNKTFQELAVFHDLEGMWQELSPKIWTFMESSSEMDLVRTLLDSRGNDDFWEQRLEGSDWTAKDIVAFLAKHPEDVQSTNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPVATEVLLINKSMELLDERKFWAGVVFTGIAPGSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFATVTILQCFLISTLFSRANLAAACGGIIYFMLYLPYVLCVAWQDYVGFTLKIFVSLMSPVAFGFGCEYFALFEEQGIGVQWDNLFESPTEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSSHKGASEICMEEEPTHLKLGVSIQNLMKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKVVSELPPAGQSGGTGGEVQRLVALTQDVSVISNLIRKHVAEARLVEDIGHELTYVLPYEAAREGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRVFGDKQSCLRPFTEDDAMDPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDVSTQELLNALTGKPGFGTRCMEGNPIPETPCLVGEEKWNTAPVPQTITDLFRNGNWTMENPSPTCQCSSDKIKKMLPVCPLGAGGLPPPQRKQNTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGASNSQSLPPSEEVNDAIKQMKKHLKVVKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGANPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVKRERQRILDGGGQNDILEIKELTKVYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSDIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFELAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2263, "header": "tr|A0AAA9T8E2-1|A0AAA9T8E2_BOVIN Isoform 1 of P-type phospholipid transporter OS=Bos taurus OX=9913 GN=ABCA1 PE=4 SV=1 CANONICAL=A0AAA9T8E2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2/entry#A0AAA9T8E2-1", "sequence": { "sequence": "MAYWPQLRLLLWKNLTFRRRQTCQLFLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDARRLLLYSHRDTSMKDIRKVLKTLYQIERFSSRLKLQDFLVDNETFSGFLHHNLSLPRPTVDKMLGADVSLRKVFLQGYQLHLSNLCNGSKLGEVIRLGDQEVSRFCSLPREKLNAAQQVLRSNLDILKPVLTKLNSTSLFPTEELGEATKALLDSLGNLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIICGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEDDAGTVYDNSTSPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPVTRRLMTEVNKTFQELAVFHDLEGMWQELSPKIWTFMESSSEMDLVRTLLDSRGNDDFWEQRLEGSDWTAKDIVAFLAKHPEDVQSTNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPVATEVLLINKSMELLDERKFWAGVVFTGIAPGSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFATVTILQCFLISTLFSRANLAAACGGIIYFMLYLPYVLCVAWQDYVGFTLKIFVSLMSPVAFGFGCEYFALFEEQGIGVQWDNLFESPTEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSSHKGASEICMEEEPTHLKLGVSIQNLMKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKVVSELPPAGQSGGTGGEVQRLVALTQDVSVISNLIRKHVAEARLVEDIGHELTYVLPYEAAREGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRVFGDKQSCLRPFTEDDAMDPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDVSTQELLNALTGKPGFGTRCMEGNPIPETPCLVGEEKWNTAPVPQTITDLFRNGNWTMENPSPTCQCSSDKIKKMLPVCPLGAGGLPPPQRKQNTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGASNSQSLPPSEEVNDAIKQMKKHLKVVKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGANPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVKRERQRILDGGGQNDILEIKELTKVYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSDIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFELAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2263, "header": "tr|A0AAA9T8E2-1|A0AAA9T8E2_BOVIN Isoform 1 of P-type phospholipid transporter OS=Bos taurus OX=9913 GN=ABCA1 PE=4 SV=1 CANONICAL=A0AAA9T8E2-1" }, "locus": { "chromosome": "8", "start_pos": 94716719, "end_pos": 94603865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106747.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106747.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094233.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094233.1" } ] } }, { "isoform_ac": "F1MG24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2/entry#F1MG24-1", "sequence": { "sequence": "MAYWPQLRLLLWKNLTFRRRQTCQLFLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDARRLLLYSHRDTSMKDIRKVLKTLYQIERFSSRLKLQDFLVDNETFSGFLHHNLSLPRPTVDKMLGADVSLRKVFLQGYQLHLSNLCNGSKLGEVIRLGDQEVSRFCSLPREKLNAAQQVLRSNLDILKPVLTKLNSTSLFPTEELGEATKALLDSLGNLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIICGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEDDAGTVYDNSTSPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPVTRRLMTEVNKTFQELAVFHDLEGMWQELSPKIWTFMESSSEMDLVRTLLDSRGNDDFWEQRLEGSDWTAKDIVAFLAKHPEDVQSTNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPVATEVLLINKSMELLDERKFWAGVVFTGIAPGSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFATVTILQCFLISTLFSRANLAAACGGIIYFMLYLPYVLCVAWQDYVGFTLKIFVSLMSPVAFGFGCEYFALFEEQGIGVQWDNLFESPTEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSSHKGASEICMEEEPTHLKLGVSIQNLMKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDMLTIDVSVISNLIRKHVAEARLVEDIGHELTYVLPYEAAREGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRVFGDKQSCLRPFTEDDAMDPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDVSTQELLNALTGKPGFGTRCMEGNPIPETPCLVGEEKWNTAPVPQTITDLFRNGNWTMENPSPTCQCSSDKIKKMLPVCPLGAGGLPPPQRKQNTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGASNSQSLPPSEEVNDAIKQMKKHLKVVKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGANPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVKRERQRILDGGGQNDILEIKELTKVYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSDIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFELAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2261, "header": "tr|F1MG24-1|F1MG24_BOVIN Computationally mapped isoform of P-type phospholipid transporter OS=Bos taurus OX=9913 GN=ABCA1 PE=4 SV=1 CANONICAL=A0AAA9T8E2-1" }, "locus": { "chromosome": "8", "start_pos": 94716719, "end_pos": 94603865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027538.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027538.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027538.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027538.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 86, "start_aa": "Thr", "end_pos": 86, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr86", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8963896", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963896", "resource": "Reactome", "description": "HDL assembly" }, { "id": "R-BTA-9029569", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9029569", "resource": "Reactome", "description": "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZLK5-1", "protein_name": "P-type phospholipid transporter", "gene_name": "Abca1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACWSQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRILLYSQKDTSIRDMHKVLRTLQQIKHPNSNLKLQDFLVDNETFSGFLQHSLSLPRSAVDNLLQADVSLQKVFLQGYQLHLASLCNGSKLEEIIRLGDLEVSALCSLPREKLDAAERELRSNMDILKPVMTKLNSTSLLPTQHLAEATTTLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNNSGSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDTDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLIGKILYTPDTPATRQVMAEVNKTFQELALFHDLEGMWEELSPQIWTFMESSQEMDLVRTMLDSRGNDQFWERKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVIILKLGDLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRTNLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFKSPVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGASEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPELPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDLDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPNLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVNEFRYGGFSLGVSDSQALPPSQEVNNAIKQMKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNYVVPATLVVIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKFNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLVTVLIQYRFFIRPRPVKARLPPLNDEDEDVRRERQRILEGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKMLTGDTAVTRGDALLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHLEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2263 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F2Y6-1", "protein_name": "P-type phospholipid transporter", "gene_name": "abca1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSISTQLGLLLWKNFTYRRRQTLQLLTEIVWPLFIFFILIAVRLYYPPYEQHECHFPNKAMPSAGTLPWIQGIVCNANNPCFRHPTPGESPGVVGNFNDSIISRLFSDAKKILLYSQNDKSLDGFKELIDAVKVMQNNTAGFKLKDFLHEDETLSTFLLQNASFTENYVTNILDADVNLEKVLIKGFGVHLRDMCSSIKLEDFVTIPDTSVARFTQDMICRSPKNWLDQAESHFKSNLDFLKPVRSEIRTNATDVRKVTKATDNLLESLGSLAVELASMRSWSDLRNEILFLTENATGSPSLMYQAVSRIVCGHPEGGGLKIKSLNWYEDSNFQALFGNHNDSDDQPVPVYDNTTTPYCNSMMRNMEASPISRMIWRALKPLLMGKILYTPHSPATQKIIHEVNKTFQELGILRDLGGMWEEARPKVWNFMENSNEMDLMRTLLLNNLTANFFSAQLAGTQWSVEDVISFLSKHSEDTRPQGTAFTWRDVFNETDQAIMSISRFMECVNLDKLEPVSTEEKLVNESMSLLDNRKFWAGIVFLDIPSNSSELPPNVNYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDLRYIWGGFSYLQDVVEHSIIRAVTGSKEKTGVYIQQMPYPCYVDDIFLRIMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLISAGLLVLLLKMGNLLPYSDPGVVFLFLGSFAVVTIMQCFLISTAFARANLAAACGGIIYFTLYLPYVLCVAWQDYVGFAAKVIASLLSPVAFGFGCEYFALFEEQGVGIQWNNLFSSPVEEDDYNLTTCLILMYFDAFLYGVMTWYIETVFPGQYGIPRPWYFPFTKSYWFGENSTNNTAIHGKKSNAGAVCIEEEPTHLKLGVYIENLVKVYRHGKKLAVDGLTLGFHEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIMGKDIRSELSSIRQSLGVCPQHNVLFSMLTVEEHIWFYARLKGLSEEEVKAEMEQILSDTGLPHKRKSRTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRAGRTILLSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCRNSSSTVSFVKKDDNASESSSDAGLGSDQESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVEDQGHEITYVLPYESAKNGAFVELFHDLDDRLADLGISSYGVSDTTLEEIFLKVAEDSGVDTEMLSDGTLPVRRQRRHAFGADHQSCLKPLTEDDSFDCNESEGDPESKETDYLSGSDGKGSYQVKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALNPWMYEEQFMFFSEDAPYDVSTHKLLRALFDDPGFGTRCMKGESIPDAPCTMGDEEWSTPEVPESIIEILTTRNWTMNDPSPACECSCNGKKKMLPECPAGAGGLPPPQIKISETETLQNLTGRNISDYLVKTYAQIIGKSLKNKIWVNEFRYGGFSLGARSTQVLPPAEEIDDAISRVREIFQLGKDSGSAADRFLKSLSAFINGLDTKNNVKIWFNNKGWHSIGAFLNVMNNGILRANLPPGKDPSEFGITAYNHPLNLTKEQLSQVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPYLYWLANFLWDMCNYVVPATLVILIFVCFQQKAYVSATNLPVLALLLLLYGWSITPLMYPASFLFKIPSTAYVVLTSVNILIGINGSISTFVMELFGNHEIGGINDILKNVLLIFPHFCLGRGLIDMVKNQAMADALERFGENRFRSPLEWDMVGKNLFAMAVEGVVFFIITVLIQYRFFFEPKSLCPKLSPIGEEDEDVARERQRIMSGAGQGDILELRQLTKVYKRKQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLTGDSVVTKGEAFIAGKSILREIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPENEVCAVAEWGIRKLGLVKYVDKNAGSYSGGNMRKLSTAISLIGAPPVVFLDEPTTGMDPKARRALWNCIHSVIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIILRVAGPDPDLQPVMKFIESELPGSTLKEKHRNMLQYQLPSSLTSLAHIFSILAKNKEFLRIEDYSVSQTTLDQVFVNFAKDQSDDHSDSSISRKGTAVNMALLTPLSTKDSLEKPMESFV", "length": 2282 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GTZ6-1", "protein_name": "P-type phospholipid transporter", "gene_name": "Abca1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDARRLLLYSQKDTSIKDIHKVLRTLRQIKHSNPNLKLQDFLVDNETFSGFLHHNLSLPRQTVDILLKADVSLQKVFLQGYQLHLSSLCNGSKLEEIIQLGDLEVSALCGLPREKLDAAERVLRYNMDILKPVVTRLNSTSPLLTQHLAEATRTLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNSTEEDMETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQLWTFMESSQEMDLVRTLLDSRGNDRFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGLTPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVIILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHLGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPRSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDVIDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTQELLNALTRDPGFGTRCMEGNPIPDTPCLVGDEDWTTAPVPQTIKDLFQNGNWTMKNPSPTCQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSQEVNDAIKQVKKLLKLTKDSSADRFLSSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILTNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2261 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95477-1", "protein_name": "Phospholipid-transporting ATPase ABCA1", "gene_name": "ABCA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2261 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41233-1", "protein_name": "Phospholipid-transporting ATPase ABCA1", "gene_name": "Abca1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKVLRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLASLCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEATTVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNNTEEDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV", "length": 2261 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q555Z5-1", "protein_name": "ABC transporter A family member 4", "gene_name": "abcA4", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MESIKNQLIPLLKKNWTLKGKSKIKLLLEILLPLISIGILFGILYLSMIITRDFKERPASGFAFDIAHTKQLLIGSNGGLNSDQRNILDNLKLQVSIQHPEFSNDYINRCFVEFKDIESMDEYFHDPFNYRGVMGGVWFPDDSFNGNTIKYSIRVDSDFTHDNTQQFQDREDSQIYLRHYFTQIQTGVDQAILLTNQIAIPIFATGQRFPNPYISFWEKWTDGRKLILLNTGGVFITASLFATLFTLITNIVIEKETKILEGMKTMGLNSFAYYISNSIISLITLLSSTLLVSIILSASQLVHHVKWITLILILIPYSITLLLIAFILCKFFTKSKYAGLMAFLIVLLLSGIGIIIGRFNISPTLKLLSCLFSPIAISVANYVWCYKDLIVFKEVDINVNMVNEYEIIGMLVFDIFLYILILWYLDNVITGEYGIPKKWYFFLTKNYWRKNKKSNINNNGVFDVEATSCNRNSSYNEKNFEKIEHQLERPTISIRNLRKEFKTGDGNRIAVNDLSIDMYKNRIHSFLGPNGSGKSTTLSMLTGMIEPTSGDALINGFDIRNNIDEIRKHLGVCPQSDIIWEQLTVMEHLEFYAALKGFTNSNQRKVEATKIALEVGLGEKLNAPAGTLSGGQKRKLCLAIAFIGPNSDIILIDEPTSGLDASNRRLIWDFILKYRENKTIILVSHYLEECDILSNTISIIANGELKCNGSSLFLKNRFGVGYLLTISKEHNSINNSNLTKTISDIIFNHIPKGSLLSDAGTELCFRLPNESIGNFSNLFKELDDRKKQLSIENYGISITTLEEVFLKIISNSETNPNFNQSVLNTALKTNSSGIKSYQQLKGLLIKRVKTSRKDIKSFVLSILIPILILAGGLILYKNMRTIDIYNTVTQPLILDFNVYGKSVTPVSIDKVNETMTSLFDNSIGHSDRTTLVPYDELHDYLIHHYFGVPGALYFDFRYFKNVKFLHYNVFFNKDYLHALPIYINFVDSEILRSVTGKRIQTTSLPFEHIQSPLEVASLDVNFVAIVFFIILTLASFSLIAASHAGNISHERSTRVKRLLYISGLRKSIYWLSNLIWDYLQTFILVIFLTIVIIAVDDKFRTHFDLYISGVVLFTFSIIPLSYLMSFKFSSHGKAVGAIFAIHFGVGLIFTVISFILRVWAIKENSISFQFLTDIIEYCFYAISPFFCFSKILAIVTKFPGVSRVDQSFIDYWSFHFGLLPNAILFLHCIVWITWILLIDYSSEIKGKFTISKLFSNSPIPDSNEDSDVSNERIIVKQLLDNNTNGGSGNVYPIIFNNLYKKFNSVGNYKSKIAVYNSTLAIPTGQTFGLLGLNGCGKSTTLGMISGEISPTGGKIKLNGYDLIKNRNDALTSIGYCFQFDALIGLLSAREQLELYCRIKGVDESKIKDTVNAFIQMMDLESISNSNTSGYSGGNKRKVSLSIACIGSPSILLLDEISCGVDACVKRFMWNVLMELKKNKAIILTTHSIAECQAVCDKLTIMKDGKLQALGSNQHIKDKFGSGYSIEVKFKKEYLENGVELFLQSFPSASLIDNQHALSASFELPNPPNNPIKLSSIFSNIEQSLKFILDDYSVSQTSIEQIFIKLTKNSITNIDN", "length": 1615 }, "evidence": [ { "id": "A0AAA9T8E2", "url": "https://omabrowser.org/oma/group/A0AAA9T8E2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 16, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "ATPase binding", "id": "GO:0051117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "apolipoprotein A-I binding", "id": "GO:0034186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "apolipoprotein A-I receptor activity", "id": "GO:0034188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034188", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phosphatidylcholine floppase activity", "id": "GO:0090554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090554", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phosphatidylserine floppase activity", "id": "GO:0090556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "sphingolipid floppase activity", "id": "GO:0046623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "protein transmembrane transporter activity", "id": "GO:0008320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008320", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cholesterol transfer activity", "id": "GO:0120020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phagocytic vesicle", "id": "GO:0045335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 22, "go_terms": [ { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cholesterol metabolic process", "id": "GO:0008203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "positive regulation of cholesterol efflux", "id": "GO:0010875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010875", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phospholipid efflux", "id": "GO:0033700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cellular response to retinoic acid", "id": "GO:0071300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "response to laminar fluid shear stress", "id": "GO:0034616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "intracellular cholesterol transport", "id": "GO:0032367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032367", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cholesterol efflux", "id": "GO:0033344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "reverse cholesterol transport", "id": "GO:0043691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043691", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "phospholipid homeostasis", "id": "GO:0055091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "regulation of Cdc42 protein signal transduction", "id": "GO:0032489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032489", "evidence": [ { "database": 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"database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "positive regulation of high-density lipoprotein particle assembly", "id": "GO:0090108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "signal release", "id": "GO:0023061", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0023061", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" }, { "name": "export across plasma membrane", "id": "GO:0140115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1144, "end_pos": 1146, "annotation": 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"end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 478, "end_pos": 480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-216723", "name": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [ "R-ALL-216762" ], "output_participant_list": [], "enzyme_list": [ "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-216723", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216723" } ] }, { "id": "R-BTA-216727", "name": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-216727", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216727" } ] }, { "id": "R-BTA-216757", "name": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [ "R-ALL-216770" ], "output_participant_list": [ "R-ALL-171142" ], "enzyme_list": [ "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-216757", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216757" } ] }, { "id": "R-BTA-5682084", "name": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZ07-1", "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-5682084", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682084" } ] }, { "id": "R-BTA-5682101", "name": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00517-1", "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-5682101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682101" } ] }, { "id": "R-BTA-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T8E2-1" ], "evidence": [ { "id": "R-BTA-5682103", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682103" } ] }, { "id": "R-BTA-9619756", "name": "NR1H2 binds ABCA1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "vesicle budding from membrane", "id": "GO:0006900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006900", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "mitotic metaphase chromosome alignment", "id": "GO:0007080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "protein polymerization", "id": "GO:0051258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051258", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "late endosome to lysosome transport", "id": "GO:1902774", "url": 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"pmid": "" }, { "name": "viral budding from plasma membrane", "id": "GO:0046761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046761", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "midbody abscission", "id": "GO:0061952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061952", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8M2" } ], "pmid": "" }, { "name": "ESCRT III complex", "id": "GO:0000815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000815", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8M2", "url": 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"biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8N9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 291, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 66, "end_pos": 68 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8R1-1", "uniprot_ac": "A0AAA9T8R1", "uniprot_id": "A0AAA9T8R1_BOVIN", "mass": { "chemical_mass": 54274.0, "monoisotopic_mass": 54274.0 }, "refseq": {}, "gene_names": [ { "name": "RFX8", "type": "recommended", "evidence": [ { "id": "A0AAA9T8R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ] } ], "protein_names": [ { "name": "Regulatory factor X8", "type": "synonym", "evidence": [ { "id": "A0AAA9T8R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be a transcription factor.", "evidence": [ { "database": "UniProtKB", "id": "E1BAR6", "url": "https://www.uniprot.org/uniprotkb/E1BAR6#function" }, { "database": "UniProtKB", "id": "ARBA00054388", "url": "https://www.uniprot.org/uniprotkb/ARBA00054388#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RFX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1", "locus": { "chromosome": "11", "start_pos": 6277900, "end_pos": 6330209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033998", "url": "https://www.ensembl.org/id/ENSBTAG00000033998" } ] } } ], "crossref": [ { "id": "A0AAA9T8R1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8R1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033998", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033998", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138955", "url": "https://www.ncbi.nlm.nih.gov/gene/100138955", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039779", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039779", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057321", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057321", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QQERTCE", "url": "https://omabrowser.org/oma/group/QQERTCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BAR6", "url": "https://www.orthodb.org/?gene=E1BAR6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12619:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12619:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25340", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25340", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAR6", "url": "https://www.uniprot.org/uniprotkb/E1BAR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAR6-1", "url": "https://www.uniprot.org/uniprotkb/E1BAR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYEIYMETCGQNAQNQVNPAMFGKGDNHSPIKTEPIGSPLSEFRRCPFWEQELAKKYSYHMVAFLADEYCNCCQDILQRVEDLLMSFWKSLQQDTVMLLSLPDVCRLLKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVRLFSKKFKLWLLSALEGFPALLQISKLKEVTVFVKRLRRKTYLSNMAKTMRMVLRNSRRVSVLKSDLCTIFHQGVLDSSQKVLPRDLSGADVLGENTEMKCLSSLISLLGTSTDLSVFMNCLSSNLQEFVFQPSRSKEEFLQLAASFQLRWNFLLTAVSKAMTLCHRDSFGSWHLFHLLLSEYVIHILQSCIEEEEEEDNVGSLKEILPDDQSPVQPDYEPHHPPDCPPAQEHESLSADPPRVMLRCKGQSPGATAGSSVVVRVPGFLVDTVTGNKLIQVLLEDKATESTIKLTLPLGQETLITLTDGQKFVIHISDVSQSSEDVYLTESNADTGDYLLD", "length": 479, "header": "tr|A0AAA9T8R1-1|A0AAA9T8R1_BOVIN Isoform 1 of Regulatory factor X8 OS=Bos taurus OX=9913 GN=RFX8 PE=4 SV=1 CANONICAL=A0AAA9T8R1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8R1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1/entry#A0AAA9T8R1-1", "sequence": { "sequence": "MYEIYMETCGQNAQNQVNPAMFGKGDNHSPIKTEPIGSPLSEFRRCPFWEQELAKKYSYHMVAFLADEYCNCCQDILQRVEDLLMSFWKSLQQDTVMLLSLPDVCRLLKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVRLFSKKFKLWLLSALEGFPALLQISKLKEVTVFVKRLRRKTYLSNMAKTMRMVLRNSRRVSVLKSDLCTIFHQGVLDSSQKVLPRDLSGADVLGENTEMKCLSSLISLLGTSTDLSVFMNCLSSNLQEFVFQPSRSKEEFLQLAASFQLRWNFLLTAVSKAMTLCHRDSFGSWHLFHLLLSEYVIHILQSCIEEEEEEDNVGSLKEILPDDQSPVQPDYEPHHPPDCPPAQEHESLSADPPRVMLRCKGQSPGATAGSSVVVRVPGFLVDTVTGNKLIQVLLEDKATESTIKLTLPLGQETLITLTDGQKFVIHISDVSQSSEDVYLTESNADTGDYLLD", "length": 479, "header": "tr|A0AAA9T8R1-1|A0AAA9T8R1_BOVIN Isoform 1 of Regulatory factor X8 OS=Bos taurus OX=9913 GN=RFX8 PE=4 SV=1 CANONICAL=A0AAA9T8R1-1" }, "locus": { "chromosome": "11", "start_pos": 6325464, "end_pos": 6278071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110752.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110752.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094358.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094358.1" } ] } }, { "isoform_ac": "E1BAR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1/entry#E1BAR6-1", "sequence": { "sequence": "MAEGVPASPLGGAGSRGLHSGIIQWLVDNFCICEGYSVPRCLMYEIYMETCGQNAQNQVNPAMFGKLVHLVFPDLGTRRLGTRGSARYHYDGICIKRSSFFYAQYCYLLGGKRCTSGDIVAFEKSTNYNRILQEEGAGDNHSPIKTEPIGSPLSEFRRCPFWEQELAKKYSYHMVAFLADEYCNCCQDILQRVRNQELEKVEDLLMSFWKSLQQDTVMLLSLPDVCRLLKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVRLFSKKFKLWLLSALEGFPALLQISKLKEVTVFVKRLRRKTYLSNMAKTMRMVLRNSRRVSVLKSDLCTIFHQGVLDSSQKVLPRDLSGADVLGENTEMKCLSSLISLLGTSTDLSVFMNCLSSNLQEFVFQPSRSKEEFLQLAASFQLRWNFLLTAVSKAMTLCHRDSFGSWHLFHLLLSEYVIHILQSCIEEEEEEDNVGSLKEILPDDQSPVQPDYEPHHPPDCPPAQEHESLSADPPRVMLRCKGQSPGATAGSSVVVRVPGFLVDTVTGNKLIQVLLEDKATESTIKLTLPLGQETLITLTDGQKFVIHISDVSQSSEDVYLTESNADTGDYLLD", "length": 600, "header": "tr|E1BAR6-1|E1BAR6_BOVIN Computationally mapped isoform of DNA-binding protein RFX8 OS=Bos taurus OX=9913 GN=RFX8 PE=4 SV=3 CANONICAL=A0AAA9T8R1-1" }, "locus": { "chromosome": "11", "start_pos": 6329951, "end_pos": 6278071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048225.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048225.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045303.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045303.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138955", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138955", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GDI7-1", "protein_name": "DNA-binding protein RFX8", "gene_name": "Rfx8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEAVPASPAGGRGLHRGIIQWLVDNFCICEGFSVPRCLMYEIYVETCGQSAQNQVNPATFGKLVRLVFPDLGTRRLGTRGSARYHYDGIYIKKSSFFYAHYCYLLGKKSCHSGDLVAFGKSPDFNNVLQQEETCESHSPIKTDPMGSPVSPFRRCPFWEQELANKYSCKLVVFLADEYCNYCRDILQYVRNQELEKVEDLITSFWKSLQQDTVMLLSLPDVRQLFGCYDMQLYKGLEDTLLPDFLEDVSIQYLKSVRLFSKRFKLWLLGALEGFPAILQISKLKEVTGFVKRLRRKTYLSNMAKTMKMVLKNSRRVGLLKSDLRAIIREGTLDISKKVLEGDSGHEEEPESHTEMKCLGCLISLLETSTDLAELLNCVSSNLQALVFQPSKSKEEFIKLAASFQLKWNFLLTAVSKAMTLSHRDSFGAWHLFHLLLLEYVIHILESCMEEEEEEEDLGSLQDLLSDDQFLTQPDQALFHSLDSLPASECASRNVESPQVTLKHMSQSCSPMGVSSMVLQVLGFLVDTATGNKLIQVLLEDKATESAVKLSLPVGQEALITLSNGQRFVIHISDVPQSSENTYCRKSDSTMPGGLLE", "length": 597 }, "evidence": [ { "id": "A0AAA9T8R1", "url": "https://omabrowser.org/oma/group/A0AAA9T8R1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3YU81-1", "protein_name": "DNA-binding protein RFX8", "gene_name": "Rfx8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEAVPASPASGLGLHRGIIQWLVDNFCICEGFSVPRCLMYEIYVETCGQSAQNQVNPATFGKLVRLVFPDLGTRRLGTRGSARYHYDGIYIKKSSFFYAHYCYLLGKKSCHSGNLIAFGKFPDYSNVLQQEETCENHSPIKKDPMGSPVSPFRRCPVWEQELANKYSCKLVVFLADEYCNYCRDILQNVRNQELEKVEDLITSFWKSRQQDTVMLMSLPDVRQLLGCYDMQLYKGLEDMLLPDFLEDVSIQYLKSVRLFSKRFKLWLLGALEGFPAILQISKLKEVTGFVKRLRRKTYLSNMAKTMKMVLKNSRRIGLLKSDLRAIIREGTLDISKKVLEGDSDHEEEPESHTEMKCLGCLISLLETSTDLAELLNCVSSNLQVLVFQPSKNKEDFIKLAASFQLKWNFLLTAVSKAMTLSHRDSFGAWHLFHLLLLEYVIHILESCIEEEEEEDLGSLQDLLSDDQFLTQPDQALFHPLDSLPTSECASRNVESPQVTLKHTSQSCGPMGMGSVVLQVLGFLVDTATGNKLVQVLLEDKTTESAVKLSLPVGQEALITLSNGQRFVIHISDVPQSSENTYCRKSNANVQGGLLE", "length": 596 }, "evidence": [ { "id": "A0AAA9T8R1", "url": "https://omabrowser.org/oma/group/A0AAA9T8R1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZV50-1", "protein_name": "DNA-binding protein RFX8", "gene_name": "RFX8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEGVPASPSSGEGSRGPHSGVIQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATFGKLVRLVFPDLGTRRLGTRGSARYHYDGICIKKSSFFYAQYCYLIGEKRYHSGDAIAFEKSTNYNSIIQQEATCEDHSPMKTDPVGSPLSEFRRCPFLEQEQAKKYSCNMMAFLADEYCNYCRDILRNVEDLLTSFWKSLQQDTVMLMSLPDVCQLFKCYDVQLYKGIEDVLLHDFLEDVSIQYLKSVQLFSKKFKLWLLNALEGVPALLQISKLKEVTLFVKRLRRKTYLSNMAKTMRMVLKSKRRVSVLKSDLQAIINQGTLATSKKALASDRSGADELENNPEMKCLRNLISLLGTSTDLRVFLSCLSSHLQAFVFQTSRSKEEFTKLAASFQLRWNLLLTAVSKAMTLCHRDSFGSWHLFHLLLLEYMIHILQSCLEEEEEEEDMGTVKEMLPDDPTLGQPDQALFHSLNSSLSQACASPSMEPLGVMPTHMGQGRYPVGVSNMVLRILGFLVDTAMGNKLIQVLLEDETTESAVKLSLPMGQEALITLKDGQQFVIQISDVPQSSEDIYFRENNANV", "length": 586 }, "evidence": [ { "id": "A0AAA9T8R1", "url": "https://omabrowser.org/oma/group/A0AAA9T8R1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8R1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8R1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8R1", "database": "UniProtKB", "url": 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"MTCPRTSPSWRASPKDAQVFSLIVFSSLLTDGYQNKTDNSELHCVLNSNSTACSFAVGAGLLAFLSSLAFLALDAHEVRLASTRFKTAFQLLDLILAVIWAGVWAVGFCFLANQWHRSPPRYFLLGSNSAKAAITFSFFSILVWIFQAYLAFQELRNDAPVPYKRSLDEGGVVLTSLSPPSAASPVNTPTTGPHGPSYASSSLSPYLSTPKAPRLAMMPDN", "length": 221, "header": "tr|F1N0T8-1|F1N0T8_BOVIN Computationally mapped isoform of Synaptogyrin OS=Bos taurus OX=9913 GN=SYNGR4 PE=3 SV=2 CANONICAL=A0AAA9T8T5-1" }, "locus": { "chromosome": "18", "start_pos": 55075034, "end_pos": 55067921, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011267.5", "url": "https://www.ensembl.org/id/ENSBTAT00000011267.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011267.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011267.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", 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[provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377049" }, "gene_names": [ { "name": "OR9S36B", "type": "recommended", "evidence": [ { "id": "A0AAA9T8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U2" } ] }, { "name": "OR9S36B", "type": "synonym", "evidence": [ { "id": "NP_001377049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377049" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9T8U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 12", "type": "synonym", "evidence": [ { "id": "NP_001377049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377049" } ] }, { "name": "olfactory receptor family 9 subfamily S member 36B", "type": "synonym", "evidence": [ { "id": "NP_001377049", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377049" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T930-1", "uniprot_ac": "A0AAA9T930", "uniprot_id": "A0AAA9T930_BOVIN", "mass": { "chemical_mass": 117354.0, "monoisotopic_mass": 117354.0 }, "refseq": {}, "gene_names": [ { "name": "CLEC16A", "type": "recommended", "evidence": [ { "id": "A0AAA9T930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930" } ] } ], "protein_names": [ { "name": "C-type lectin domain containing 16A", "type": "synonym", "evidence": [ { "id": "A0AAA9T930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T930", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLEC16A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930", "locus": { "chromosome": "25", "start_pos": 9873385, "end_pos": 9621305, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005208", "url": "https://www.ensembl.org/id/ENSBTAG00000005208" } ] } } ], "crossref": [ { "id": "A0AAA9T930", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T930", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005208", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005208", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615054", "url": "https://www.ncbi.nlm.nih.gov/gene/615054", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615054", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615054", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LW98", "url": "https://www.orthodb.org/?gene=A0A3Q1LW98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MQK7", "url": "https://www.orthodb.org/?gene=F1MQK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21481", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21481", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21481:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21481:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LW98", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW98-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T930", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T930-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQK7", "url": "https://www.uniprot.org/uniprotkb/F1MQK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MQK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSSAQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPADDPMITEQPQPNLPDQLVIVNETEAESRPGKSLARSADVETVTLSPSLTPAQQPTISLLCEDAADTLSVESLTLVPPVDRHSLHALTGIPPPPSPAMVGTEALSSGAGQPEPADPTEP", "length": 1050, "header": "tr|A0AAA9T930-1|A0AAA9T930_BOVIN Isoform 1 of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=1 CANONICAL=A0AAA9T930-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#A0A3Q1LW98-1", "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSSAQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPADDPMITEQPQPNLPDQLVIVNETEAESRPGKSLARSADVETVTLSPSLTPAQQPTISLLCEDAADTLSVESLTLVPPVDRHSLHALTGIPPPPSPAMVGTEALSSGAGQPEPADPTEP", "length": 1048, "header": "tr|A0A3Q1LW98-1|A0A3Q1LW98_BOVIN Computationally mapped isoform of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=2 CANONICAL=A0AAA9T930-1" }, "locus": { "chromosome": "25", "start_pos": 9852508, "end_pos": 9621481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081113.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081113.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064973.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064973.2" } ] } }, { "isoform_ac": "A0AAA9T930-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#A0AAA9T930-1", "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSSAQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPADDPMITEQPQPNLPDQLVIVNETEAESRPGKSLARSADVETVTLSPSLTPAQQPTISLLCEDAADTLSVESLTLVPPVDRHSLHALTGIPPPPSPAMVGTEALSSGAGQPEPADPTEP", "length": 1050, "header": "tr|A0AAA9T930-1|A0AAA9T930_BOVIN Isoform 1 of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=1 CANONICAL=A0AAA9T930-1" }, "locus": { "chromosome": "25", "start_pos": 9852508, "end_pos": 9621481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096461.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096461.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095204.1" } ] } }, { "isoform_ac": "A0AAA9TY44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#A0AAA9TY44-1", "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSSAQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPAVRSGRKGRRRVFSLSEADSHGGHWV", "length": 955, "header": "tr|A0AAA9TY44-1|A0AAA9TY44_BOVIN Computationally mapped isoform of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=1 CANONICAL=A0AAA9T930-1" }, "locus": { "chromosome": "25", "start_pos": 9848751, "end_pos": 9621481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114970.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114970.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102117.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102117.1" } ] } }, { "isoform_ac": "A0AAA9TZT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#A0AAA9TZT0-1", "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPADDPMITEQPQPNLPDQLVIVNETEAESRPGKSLARSADVETVTLSPSLTPAQQPTISLLCEDAADTLSVESLTLVPPVDRHSLHALTGIPPPPSPAMVGTEALSSGAGQPEPADPTEP", "length": 993, "header": "tr|A0AAA9TZT0-1|A0AAA9TZT0_BOVIN Computationally mapped isoform of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=1 CANONICAL=A0AAA9T930-1" }, "locus": { "chromosome": "25", "start_pos": 9852508, "end_pos": 9621481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131063.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131063.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102259.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102259.1" } ] } }, { "isoform_ac": "F1MQK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T930/entry#F1MQK7-1", "sequence": { "sequence": "MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSETYAKPEQDVQRSCAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPAEDAQEDAEKAKGTEGGSKGIKTSGENEEIEMVIMERSKLPELAASTSVQEQNTTDEEKSAATGLDSVQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPTAAEKTTYNHLLAERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVVTSTGCIIKDVHLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRALSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVVAKDGGMLQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSSAQHLPFRFYDQCRRGSSDPTVQRSVFASVDRVPGFAVAQCINQHSSSSLSSPSPSASGSPSGSGSTSHCDSGGASSSSTPSAAQSPAETEVKSRAFSSCGSGCPTYIPQPSPPPAPLKEL", "length": 963, "header": "tr|F1MQK7-1|A0AAA9T930_BOVIN Computationally mapped isoform of C-type lectin domain containing 16A OS=Bos taurus OX=9913 GN=CLEC16A PE=3 SV=4 CANONICAL=A0AAA9T930-1" }, "locus": { "chromosome": "25", "start_pos": 9873383, "end_pos": 9621481, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061555.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061555.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053301.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053301.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 924, "start_aa": "Thr", "end_pos": 924, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr924", "evidence": [ { "id": "", "database": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9C6-1", "uniprot_ac": "A0AAA9T9C6", "uniprot_id": "A0AAA9T9C6_BOVIN", "mass": { "chemical_mass": 40368.0, "monoisotopic_mass": 40368.0 }, "refseq": {}, "gene_names": [ { "name": "TRUB1", "type": "recommended", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ] } ], "protein_names": [ { "name": "tRNA pseudouridine(55) synthase", "type": "recommended", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.25", "type": "synonym", "evidence": [ { "id": "A0AAA9T9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation.", "evidence": [ { "database": "UniProtKB", "id": "E1BEB7", "url": "https://www.uniprot.org/uniprotkb/E1BEB7#function" }, { "database": "UniProtKB", "id": "ARBA00059404", "url": "https://www.uniprot.org/uniprotkb/ARBA00059404#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRUB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6", "locus": { "chromosome": "26", "start_pos": 35419096, "end_pos": 35387395, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012955", "url": "https://www.ensembl.org/id/ENSBTAG00000012955" } ] } } ], "crossref": [ { "id": "A0AAA9T9C6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9C6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012955", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012955", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002501", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002501", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014780", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014780", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BEB7", "url": "https://www.orthodb.org/?gene=E1BEB7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13767", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13767", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13767:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13767:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01509", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01509", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "42532", "url": "https://www.rhea-db.org/rhea/42532", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54572", "url": "https://www.rhea-db.org/rhea/54572", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56644", "url": "https://www.rhea-db.org/rhea/56644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEB7", "url": "https://www.uniprot.org/uniprotkb/E1BEB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEB7-1", "url": "https://www.uniprot.org/uniprotkb/E1BEB7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAEAAAAVVLSSFLKADPAPVPESAGTAAATAATSSAMAAAAAVAAAARTGSEARVSKPALATKLLSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGGTLDSAARGVLVVGIGRGTKMLTSMLSGSKRYVAIGELGKATDTLDSTGNVTEEKPYDKITQEDIESILQKFTGNIMQVPPLIILSRFLNLSSFLLPSSLFVSLFYFASYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSLSLQKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCANVLELTRTKQGPFTLEEHALPEDKWTIDDIAQSLQRCSSLLPAELALKKSKPEESNEQVLSCECITLNETKGEDDVIKTL", "length": 379, "header": "tr|A0AAA9T9C6-1|A0AAA9T9C6_BOVIN Isoform 1 of tRNA pseudouridine(55) synthase OS=Bos taurus OX=9913 GN=TRUB1 PE=3 SV=1 CANONICAL=A0AAA9T9C6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6/entry#A0AAA9T9C6-1", "sequence": { "sequence": "MAAAEAAAAVVLSSFLKADPAPVPESAGTAAATAATSSAMAAAAAVAAAARTGSEARVSKPALATKLLSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWTKRKKQTLKIGHGGTLDSAARGVLVVGIGRGTKMLTSMLSGSKRYVAIGELGKATDTLDSTGNVTEEKPYDKITQEDIESILQKFTGNIMQVPPLIILSRFLNLSSFLLPSSLFVSLFYFASYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSLSLQKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCANVLELTRTKQGPFTLEEHALPEDKWTIDDIAQSLQRCSSLLPAELALKKSKPEESNEQVLSCECITLNETKGEDDVIKTL", "length": 379, "header": "tr|A0AAA9T9C6-1|A0AAA9T9C6_BOVIN Isoform 1 of tRNA pseudouridine(55) synthase OS=Bos taurus OX=9913 GN=TRUB1 PE=3 SV=1 CANONICAL=A0AAA9T9C6-1" }, "locus": { "chromosome": "26", "start_pos": 35418092, "end_pos": 35387556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114007.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114007.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092508.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092508.1" } ] } }, { "isoform_ac": "E1BEB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6/entry#E1BEB7-1", "sequence": { "sequence": "MAAAEAAAAVVLSSFLKADPAPVPESAGTAAATAATSSAMAAAAAVAAAARTGSEARVSKPALATKLLSLSGVFAVHKPKGPTSAELLNRLKEKLLAVVGIGRGTKMLTSMLSGSKRYVAIGELGKATDTLDSTGNVTEEKPYDKITQEDIESILQKFTGNIMQVPPLYSALKKDGQRLSTLMKRGEVVEAKPARPVTVYSLSLQKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCANVLELTRTKQGPFTLEEHALPEDKWTIDDIAQSLQRCSSLLPAELALKKSKPEESNEQVLSCECITLNETKGEDDVIKTL", "length": 319, "header": "tr|E1BEB7-1|A0AAA9T9C6_BOVIN Computationally mapped isoform of tRNA pseudouridine(55) synthase OS=Bos taurus OX=9913 GN=TRUB1 PE=3 SV=3 CANONICAL=A0AAA9T9C6-1" }, "locus": { "chromosome": "26", "start_pos": 35418092, "end_pos": 35387556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017209.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017209.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017209.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017209.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 83, "start_aa": "Thr", "end_pos": 83, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr83", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "tRNA pseudouridine synthesis", "id": "GO:0031119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031119", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "mRNA pseudouridine synthesis", "id": "GO:1990481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990481", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "positive regulation of pre-miRNA processing", "id": "GO:2000633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000633", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "pre-miRNA binding", "id": "GO:0070883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070883", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "tRNA pseudouridine(55) synthase activity", "id": "GO:0160148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160148", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" }, { "name": "pseudouridine synthase activity", "id": "GO:0009982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9C6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "42532", "name": "", "equation": "uridine(55) in tRNA = pseudouridine(55) in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MRD5-1", "A0AAA9T9C6-1" ], "evidence": [ { "id": "42532", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42532" } ] }, { "id": "54572", "name": "", "equation": "a uridine in tRNA = a pseudouridine in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "E1BDL3-1", "A0AAA9TCW3-1", "A0AAA9T9C6-1", "Q17QT4-1" ], "evidence": [ { "id": "54572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54572" } ] }, { "id": "56644", "name": "", "equation": "a uridine in mRNA = a pseudouridine in mRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ 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] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539739", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539739", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SQRYQNY", "url": "https://omabrowser.org/oma/group/SQRYQNY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MY95", "url": "https://www.orthodb.org/?gene=F1MY95", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11537:SF182", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11537:SF182", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02214", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02214", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11601", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11601", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11879", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11879", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5576894", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576894", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024845386", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T6A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY95", "url": "https://www.uniprot.org/uniprotkb/F1MY95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY95-1", "url": "https://www.uniprot.org/uniprotkb/F1MY95-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELLGTPEEENMGKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL", "length": 636, "header": "tr|A0AAA9T6A8-1|A0AAA9T6A8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily D member 3 OS=Bos taurus OX=9913 GN=KCND3 PE=4 SV=1 CANONICAL=A0AAA9T6A8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6A8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A8/entry#A0AAA9T6A8-1", "sequence": { "sequence": "MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELLGTPEEENMGKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL", "length": 636, "header": "tr|A0AAA9T6A8-1|A0AAA9T6A8_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily D member 3 OS=Bos taurus OX=9913 GN=KCND3 PE=4 SV=1 CANONICAL=A0AAA9T6A8-1" }, "locus": { "chromosome": "3", "start_pos": 31530745, "end_pos": 31311513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107160.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107160.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092103.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092103.1" } ] } }, { "isoform_ac": "F1MY95-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6A8/entry#F1MY95-1", "sequence": { "sequence": "MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELLGTPEEENMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL", "length": 655, "header": "tr|F1MY95-1|F1MY95_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily D member 3 OS=Bos taurus OX=9913 GN=KCND3 PE=4 SV=2 CANONICAL=A0AAA9T6A8-1" }, "locus": { "chromosome": "3", "start_pos": 31530745, "end_pos": 31311513, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044879.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044879.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042331.2", "url": "https://www.ensembl.org/id/ENSBTAP00000042331.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:539739", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539739", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" }, { "id": "R-BTA-5576894", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576894", "resource": "Reactome", "description": "Phase 1 - inactivation of fast Na+ channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P8P4-1", "protein_name": "Potassium voltage-gated channel subfamily D member 3", "gene_name": "KCND3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGVAAWLPFARAAAIGWMPVANCPMPLAPTEKNKRQDELIILNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQEGSMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGNKELPCGERYAVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGSTEDEQHTTKGTSLIESQHHHLLHCLEKTTNHEFIDEQLFEQNCMESSMQNYPSSRSPSLSSHHGLTTSCCSRRHKKTTHLPNSSVPATRLRSMQELSTIHIQCSEQPSLTTSRSSLNMKSDDGLRPNCKAAQITTAIISIPTPPALTPEGESRPPPSSPGHSTNISTTTTSNIVKVSAL", "length": 639 }, "evidence": [ { "id": "A0AAA9T6A8", "url": "https://omabrowser.org/oma/group/A0AAA9T6A8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q62897-1", "protein_name": "A-type voltage-gated potassium channel KCND3", "gene_name": "Kcnd3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSVL", "length": 655 }, "evidence": [ { "id": "A0AAA9T6A8", "url": "https://omabrowser.org/oma/group/A0AAA9T6A8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UK17-1", "protein_name": "A-type voltage-gated potassium channel KCND3", "gene_name": "KCND3", 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"database": "Ensembl Peptide", "id": "ENSBTAP00000091082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091082.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5Q5" }, { "id": "PS00214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cytosolic fatty-acid binding proteins", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 24, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 35, "end_pos": 37 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T8Q6-1", "uniprot_ac": "A0AAA9T8Q6", "uniprot_id": "A0AAA9T8Q6_BOVIN", "mass": { "chemical_mass": 74842.0, "monoisotopic_mass": 74842.0 }, "refseq": {}, "gene_names": [ { "name": "SESTD1", "type": "recommended", "evidence": [ { "id": "A0AAA9T8Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ] } ], "protein_names": [ { "name": "SEC14 domain and spectrin repeat-containing protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9T8Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6/entry#names_and_taxonomy" } ] }, { "name": "Huntingtin-interacting protein-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T8Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SAM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM3#function" }, { "database": "UniProtKB", "id": "ARBA00054512", "url": "https://www.uniprot.org/uniprotkb/ARBA00054512#function" }, { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6#function" }, { "database": "UniProtKB", "id": "F1N429", "url": "https://www.uniprot.org/uniprotkb/F1N429#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SESTD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6", "locus": { "chromosome": "2", "start_pos": 17773835, "end_pos": 17618997, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001861", "url": "https://www.ensembl.org/id/ENSBTAG00000001861" } ] } } ], "crossref": [ { "id": "A0AAA9T8Q6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T8Q6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "789054", "url": "https://www.ncbi.nlm.nih.gov/gene/789054", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789054", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789054", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PDAFWDK", "url": "https://omabrowser.org/oma/group/PDAFWDK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N429", "url": "https://www.orthodb.org/?gene=F1N429", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46607", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46607", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46607:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46607:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24915", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24915", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N429", "url": "https://www.uniprot.org/uniprotkb/F1N429", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N429-1", "url": "https://www.uniprot.org/uniprotkb/F1N429-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHTRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEVEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPEMMTTES", "length": 658, "header": "tr|A0AAA9T8Q6-1|A0AAA9T8Q6_BOVIN Isoform 1 of SEC14 domain and spectrin repeat-containing protein 1 OS=Bos taurus OX=9913 GN=SESTD1 PE=3 SV=1 CANONICAL=A0AAA9T8Q6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6/entry#A0AAA9SAM3-1", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHTRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEVEAVGKSLLDRLTVPVVYPDGSVSSKLFCMDNAPF", "length": 668, "header": "tr|A0AAA9SAM3-1|A0AAA9T8Q6_BOVIN Computationally mapped isoform of SEC14 domain and spectrin repeat-containing protein 1 OS=Bos taurus OX=9913 GN=SESTD1 PE=3 SV=1 CANONICAL=A0AAA9T8Q6-1" }, "locus": { "chromosome": "2", "start_pos": 17773448, "end_pos": 17669276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091965.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091965.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080953.1" } ] } }, { "isoform_ac": "A0AAA9T8Q6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6/entry#A0AAA9T8Q6-1", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHTRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEVEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPEMMTTES", "length": 658, "header": "tr|A0AAA9T8Q6-1|A0AAA9T8Q6_BOVIN Isoform 1 of SEC14 domain and spectrin repeat-containing protein 1 OS=Bos taurus OX=9913 GN=SESTD1 PE=3 SV=1 CANONICAL=A0AAA9T8Q6-1" }, "locus": { "chromosome": "2", "start_pos": 17763867, "end_pos": 17669276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089077.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089077.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093198.1" } ] } }, { "isoform_ac": "F1N429-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6/entry#F1N429-1", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHTRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEVEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPEMMTTES", "length": 696, "header": "tr|F1N429-1|F1N429_BOVIN Computationally mapped isoform of SEC14 domain and spectrin repeat-containing protein 1 OS=Bos taurus OX=9913 GN=SESTD1 PE=3 SV=3 CANONICAL=A0AAA9T8Q6-1" }, "locus": { "chromosome": "2", "start_pos": 17763867, "end_pos": 17669276, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038616.6", "url": "https://www.ensembl.org/id/ENSBTAT00000038616.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038429.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038429.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789054", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789054", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RW10-1", "protein_name": "SEC14 and spectrin domain containing 1", "gene_name": "SESTD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTSMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGTLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKDRSIDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRTQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKALQQQLSDVCYRQASQLEFRQNLLQAALEFHSVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDLGLQGLREKGQSLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTLTSEERVQRLETAVAFHSSAEKILQECPEQPEAFNEMEQFDEIEAVGKSLLDRLTVPVVYPDGSEQYFGSPSDMASAAEHIREKMKLVSLKKQQLRQPEATTPES", "length": 696 }, "evidence": [ { "id": "A0AAA9T8Q6", "url": "https://omabrowser.org/oma/group/A0AAA9T8Q6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HAC7-1", "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "Sestd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGSEQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEALNDEEQFEEIEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPEMVTAES", "length": 696 }, "evidence": [ { "id": "A0AAA9T8Q6", "url": "https://omabrowser.org/oma/group/A0AAA9T8Q6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7SX85-1", "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "sestd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEASCILPVLKKKLAFLSGGKDRRSGLILTIPLCTEQTSMEELSTTLDYLLGIPSEKCKARGFTVIVDGRKSQWNIVKTVVLMLQNVIPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTDEFGGSLLYDHLDWVNKRLVFEKFTKESTSLLDELIVINENEKGSQAEKDRSSESNILPSFDPETVLQTGHELLSELQQRRFNGSEGGGGGGTAWSPMDDELLAQPQVMKLLDSLREQYTKYQEVCRQRSKRSQLEEIQTKVMQVVNWLEGPGTDQLRTQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLSAGDEEDLMELKGLQQQLSDVCYRQASQLEFRQNVLQSAYEFHMTAQDLSQQLDGLLGMLCADVAPADGAAIQQTLKHLEEKLKSVESALQTLREKGQALLDQMSNQTSFSYGKEVGVENKENIDHIHSVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLGELLDALLKTHIRLGDDSQETKVLLEKHKKFVDVAQSTYDYGRQLLQATVVLCQSLRCTTRSSGDTLPRLNRVWKQFTVTSDERQHRLEMASAFHTAAEKIVRESPELAELLVDVEAYEEVETLGKGLLDRLTVPVIFPDGSEQFFGSPGDMASSAESIRERMKLVEEKRFLQEEAEQRLEEEEEEEEAALEVEPRES", "length": 714 }, "evidence": [ { "id": "A0AAA9T8Q6", "url": "https://omabrowser.org/oma/group/A0AAA9T8Q6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80UK0-1", "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "Sestd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTSMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVLMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNEQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDASQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTVASEERVHRLEMAIAFHSNAEKILQDCPEEPEAMNDEEQFEEIEAIGKSLLDRLTIPVVYPDGTEQYFGSPSDMASTAEHIRDRMKLVSLKRQQLRHPELVTTES", "length": 696 }, "evidence": [ { "id": "A0AAA9T8Q6", "url": "https://omabrowser.org/oma/group/A0AAA9T8Q6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86VW0-1", "protein_name": "SEC14 domain and spectrin repeat-containing protein 1", "gene_name": "SESTD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES", "length": 696 }, "evidence": [ { "id": "A0AAA9T8Q6", "url": "https://omabrowser.org/oma/group/A0AAA9T8Q6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate binding", "id": "GO:0070273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "phosphatidic acid binding", "id": "GO:0070300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "id": "GO:1904878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904878", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "intermediate filament cytoskeleton", "id": "GO:0045111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045111", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" }, { "name": "calcium channel complex", "id": "GO:0034704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Q6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T8Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Q6" }, { "id": "PF24915", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24915" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SESTD1-like spectrin repeats region", "eco_id": "ECO_0000259", "start_pos": 340, "end_pos": 449, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 188, "end_pos": 190 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6M6-1", "uniprot_ac": "A0AAA9T6M6", "uniprot_id": "A0AAA9T6M6_BOVIN", "mass": { "chemical_mass": 75901.0, "monoisotopic_mass": 75901.0 }, "refseq": {}, "gene_names": [ { "name": "KLHL1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ] } ], "protein_names": [ { "name": "Kelch like family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T6M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6", "locus": { "chromosome": "12", "start_pos": 43998524, "end_pos": 44525321, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008647", "url": "https://www.ensembl.org/id/ENSBTAG00000008647" } ] } } ], "crossref": [ { "id": "A0AAA9T6M6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6M6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008647", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008647", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18335", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18335", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18509", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18509", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614976", "url": "https://www.ncbi.nlm.nih.gov/gene/614976", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614976", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614976", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GFEHWGP", "url": "https://omabrowser.org/oma/group/GFEHWGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N065", "url": "https://www.orthodb.org/?gene=F1N065", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N065", "url": "https://www.uniprot.org/uniprotkb/F1N065", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N065-1", "url": "https://www.uniprot.org/uniprotkb/F1N065-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPSAGSPAGGSCLQQDGSSSFEHWGPSQSRLLKSQEKGGVSTFWKKPSSSASSSSSASPSSSASSFSPLNGTLLPVATRLQPGAPGQGIHQPARTLFYVESLEEEEVPGMDFPGPHDKGLVPQEFKVEPANSSQATGEGCGHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEETIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 689, "header": "tr|A0AAA9T6M6-1|A0AAA9T6M6_BOVIN Isoform 1 of Kelch like family member 1 OS=Bos taurus OX=9913 GN=KLHL1 PE=4 SV=1 CANONICAL=A0AAA9T6M6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6/entry#A0AAA9T6M6-1", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPSAGSPAGGSCLQQDGSSSFEHWGPSQSRLLKSQEKGGVSTFWKKPSSSASSSSSASPSSSASSFSPLNGTLLPVATRLQPGAPGQGIHQPARTLFYVESLEEEEVPGMDFPGPHDKGLVPQEFKVEPANSSQATGEGCGHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEETIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 689, "header": "tr|A0AAA9T6M6-1|A0AAA9T6M6_BOVIN Isoform 1 of Kelch like family member 1 OS=Bos taurus OX=9913 GN=KLHL1 PE=4 SV=1 CANONICAL=A0AAA9T6M6-1" }, "locus": { "chromosome": "12", "start_pos": 44525321, "end_pos": 43998995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126485.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126485.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092397.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092397.1" } ] } }, { "isoform_ac": "F1N065-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6/entry#F1N065-1", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPSAGSPAGGSCLQQDGSSSFEHWGPSQSRLLKSQEKGGVSTFWKKPSSSASSSSSASPSSSASSFSPLNGTLLPVATRLQPGAPGQGIHQPARTLFYVESLEEEEVPGMDFPGPHDKGLVPQEFKVEPANSSQATGEGCGHRLSETSHLLTPQSDMDSGSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEETIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 750, "header": "tr|F1N065-1|F1N065_BOVIN Computationally mapped isoform of Kelch like family member 1 OS=Bos taurus OX=9913 GN=KLHL1 PE=4 SV=3 CANONICAL=A0AAA9T6M6-1" }, "locus": { "chromosome": "12", "start_pos": 44525321, "end_pos": 43998995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011402.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011402.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011402.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011402.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614976", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614976", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QSM1-1", "protein_name": "Kelch like family member 1", "gene_name": "KLHL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPSPGGPAGGSCLQQDSSGSFEHWGPSQSRLLKSQEKGSVSTFWKKPSSSSSSSSSASTSSSSSSFNPLNGTLLPVATRLQQGAPGQGTHQPARTLFYVESLEEEEVPGMDFPGPHEKGLVLQELRVEPATSSQATGEGCGHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEETIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVASLNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQT", "length": 689 }, "evidence": [ { "id": "A0AAA9T6M6", "url": "https://omabrowser.org/oma/group/A0AAA9T6M6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A9J8-1", "protein_name": "Kelch-like family member 1", "gene_name": "Klhl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPASGSSAGGSCLQQDSGGGSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSTSSSSSSSASSSPFSPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFPGPQDKGLALKELQAEPASSIQATGEGCGHRLTTTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCGDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 750 }, "evidence": [ { "id": "A0AAA9T6M6", "url": "https://omabrowser.org/oma/group/A0AAA9T6M6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JI74-1", "protein_name": "Kelch-like protein 1", "gene_name": "Klhl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPASSSPAGGSCLQQDSGGGSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFSGPEDKGLALKELQAEPASSIQATGEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 751 }, "evidence": [ { "id": "A0AAA9T6M6", "url": "https://omabrowser.org/oma/group/A0AAA9T6M6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR64-1", "protein_name": "Kelch-like protein 1", "gene_name": "KLHL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSGRKDFDVKHILRLRWKLFSHPSPSTGGPAGGGCLQQDGSGSFEHWGPSQSRLLKSQERSGVSTFWKKPSSSSSSSSSPSSSSSSFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVPGMDFPGPHEKGLVLQELKVEPDNSSQATGEGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP", "length": 748 }, "evidence": [ { "id": "A0AAA9T6M6", "url": "https://omabrowser.org/oma/group/A0AAA9T6M6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "dendrite development", "id": "GO:0016358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6M6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 95, "end_pos": 97, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T6M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6M6" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 167, "end_pos": 220, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 95, "end_pos": 97 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T780-1", "uniprot_ac": "A0AAA9T780", "uniprot_id": "A0AAA9T780_BOVIN", "mass": { "chemical_mass": 45432.0, "monoisotopic_mass": 45432.0 }, "refseq": {}, "gene_names": [ { "name": "IL11RA", "type": "recommended", "evidence": [ { "id": "A0AAA9T780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ] } ], "protein_names": [ { "name": "Interleukin 11 receptor subunit alpha", "type": "synonym", "evidence": [ { "id": "A0AAA9T780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL11RA", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780", "locus": { "chromosome": "8", "start_pos": 76027342, "end_pos": 76017927, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014907", "url": "https://www.ensembl.org/id/ENSBTAG00000014907" } ] } } ], "crossref": [ { "id": "A0AAA9T780", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T780", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014907", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014907", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUS3", "url": "https://www.orthodb.org/?gene=A0A3Q1LUS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48483", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48483", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48483:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48483:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBH9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T780-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSCSGLSRVLVAVAAALVSASSPCPQAWGPPGVQYGQLGRALMLCCPGVTAGAPVSWFRDGETRLLQGPASGLGPKLVLARAESTDEGTYTCRTLDGALRGMVTLRLGYPPARPVVSCRAADYENFSCTWSPSQVSGLPTRYLTSYRKKTVPGADGQRMSPSTGPWPCLQDPPGAARCIVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPRQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHVVRVSARDFLDAGTWSSWSPEAWGTPSTEPLPKEMPVGDQQHTQTEEEPQADSPAPPKPSLLPDPQPLDHRDPLEQVAVLASLGIFSFLGLVAGALALGLWLRLRPDEKDGPQKSGLLAPMISVDKLPGCWGS", "length": 422, "header": "tr|A0AAA9T780-1|A0AAA9T780_BOVIN Isoform 1 of Interleukin 11 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL11RA PE=3 SV=1 CANONICAL=A0AAA9T780-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780/entry#A0A3Q1LUS3-1", "sequence": { "sequence": "MSVCETSQQSRLVQLSASMPMSSSCSGLSRVLVAVAAALVSASSPCPQAWGPPGVQYGQLGRALMLCCPGVTAGAPVSWFRDGETRLLQGPASGLGPKLVLARAESTDEGTYTCRTLDGALRGMVTLRLGYPPARPVVSCRAADYENFSCTWSPSQVSGLPTRYLTSYRKKTVPGADGQRMSPSTGPWPCLQDPPGAARCIVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPRQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHVVRVSARDFLDAGTWSSWSPEAWGTPSTEPLPKEMPVGDQQHTQTEEEPQADSPAPPKPSLLPDPQPLDHRDPLEQVAVLASLGIFSFLGLVAGALALGLWLRLRPDEKDGPQKSGLLAPMISVDKLPGVPNL", "length": 442, "header": "tr|A0A3Q1LUS3-1|A0A3Q1LUS3_BOVIN Computationally mapped isoform of Interleukin 11 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL11RA PE=3 SV=2 CANONICAL=A0AAA9T780-1" }, "locus": { "chromosome": "8", "start_pos": 76026963, "end_pos": 76018152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084721.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084721.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058985.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058985.2" } ] } }, { "isoform_ac": "A0AAA9SBH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780/entry#A0AAA9SBH9-1", "sequence": { "sequence": "MSSSCSGLSRVLVAVAAALVSASSPCPQAWGPPDPPARPVVSCRAADYENFSCTWSPSQVSGLPTRYLTSYRKKTVPGADGQRMSPSTGPWPCLQDPPGAARCIVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPRQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHVVRVSARDFLDAGTWSSWSPEAWGTPSTEPLPKEMPVGDQQHTQTEEEPQADSPAPPKPSLLPDPQPLDHRDPLEQVAVLASLGIFSFLGLVAGALALGLWLRLRPDEKDGPQKSGLLAPMISVDKLPGVPNL", "length": 345, "header": "tr|A0AAA9SBH9-1|A0AAA9T780_BOVIN Computationally mapped isoform of Interleukin 11 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL11RA PE=3 SV=1 CANONICAL=A0AAA9T780-1" }, "locus": { "chromosome": "8", "start_pos": 76026963, "end_pos": 76020863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101946.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101946.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083443.1" } ] } }, { "isoform_ac": "A0AAA9T780-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780/entry#A0AAA9T780-1", "sequence": { "sequence": "MSSSCSGLSRVLVAVAAALVSASSPCPQAWGPPGVQYGQLGRALMLCCPGVTAGAPVSWFRDGETRLLQGPASGLGPKLVLARAESTDEGTYTCRTLDGALRGMVTLRLGYPPARPVVSCRAADYENFSCTWSPSQVSGLPTRYLTSYRKKTVPGADGQRMSPSTGPWPCLQDPPGAARCIVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPRQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHVVRVSARDFLDAGTWSSWSPEAWGTPSTEPLPKEMPVGDQQHTQTEEEPQADSPAPPKPSLLPDPQPLDHRDPLEQVAVLASLGIFSFLGLVAGALALGLWLRLRPDEKDGPQKSGLLAPMISVDKLPGCWGS", "length": 422, "header": "tr|A0AAA9T780-1|A0AAA9T780_BOVIN Isoform 1 of Interleukin 11 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL11RA PE=3 SV=1 CANONICAL=A0AAA9T780-1" }, "locus": { "chromosome": "8", "start_pos": 76026673, "end_pos": 76020863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135281.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135281.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092457.1" } ] } }, { "isoform_ac": "A0AAA9TUZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780/entry#A0AAA9TUZ3-1", "sequence": { "sequence": "MSSSCSGLSRVLVAVAAALVSASSPCPQAWGPPGVQYGQLGRALMLCCPGVTAGAPVSWFRDGETRLLQGPASGLGPKLVLARAESTDEGTYTCRTLDGALRGMVTLRLGYPPARPVVSCRAADYENFSCTWSPSQVSGLPTRYLTSYRKKTVPGADGQRMSPSTGPWPCLQDPPGAARCIVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPRQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHVVRVSARDFLDAGTWSSWSPEAWGTPSTEPLPKEMPVGDQQHTQTEEEPQADSPAPPKPSLLPDPQPLDHRDPLEQVAVLASLGIFSFLGLVAGALALGLWSPKPV", "length": 395, "header": "tr|A0AAA9TUZ3-1|A0AAA9TUZ3_BOVIN Computationally mapped isoform of Interleukin 11 receptor subunit alpha OS=Bos taurus OX=9913 GN=IL11RA PE=3 SV=1 CANONICAL=A0AAA9T780-1" }, "locus": { "chromosome": "8", "start_pos": 76026965, "end_pos": 76020863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102163.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102163.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101199.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101199.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "interleukin-11 receptor activity", "id": "GO:0004921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004921", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ], "pmid": "" }, { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "head development", "id": "GO:0060322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T780", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 112, "end_pos": 219, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9T780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T780" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 95, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 194, "end_pos": 196 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T863-1", "uniprot_ac": "A0AAA9T863", "uniprot_id": "A0AAA9T863_BOVIN", "mass": { "chemical_mass": 20394.0, "monoisotopic_mass": 20394.0 }, "refseq": {}, "gene_names": [ { "name": "JOSD2", "type": "recommended", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ] } ], "protein_names": [ { "name": "Josephin-2", "type": "recommended", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#names_and_taxonomy" } ] }, { "name": "Josephin domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.", "evidence": [ { "database": "UniProtKB", "id": "F1ME39", "url": "https://www.uniprot.org/uniprotkb/F1ME39#function" }, { "database": "UniProtKB", "id": "ARBA00058284", "url": "https://www.uniprot.org/uniprotkb/ARBA00058284#function" }, { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863#function" } ] }, { "annotation": "Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S9X7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X7#function" }, { "database": "UniProtKB", "id": "ARBA00037708", "url": "https://www.uniprot.org/uniprotkb/ARBA00037708#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JOSD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863", "locus": { "chromosome": "18", "start_pos": 56633686, "end_pos": 56637501, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006839", "url": "https://www.ensembl.org/id/ENSBTAG00000006839" } ] } } ], "crossref": [ { "id": "A0AAA9T863", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T863", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006839", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006839", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112441489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13291:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13291:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02099", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02099", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689877", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689877", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S9X7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9X7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T863-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME39", "url": "https://www.uniprot.org/uniprotkb/F1ME39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME39-1", "url": "https://www.uniprot.org/uniprotkb/F1ME39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPGGQQGPDPARDAWGLGFSPGVTRVPGTAGARAVLGVEGAPRRGEIGSWLAPDSRLNPHRSLLGTGNYDVNVIMAALQGQGLAAVWWDRRRPLSQLALPRVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEVLGDEDGVRAFLAAALAQGLCEVLLVVTKEVEEQGSWLQAD", "length": 190, "header": "tr|A0AAA9T863-1|A0AAA9T863_BOVIN Isoform 1 of Josephin-2 OS=Bos taurus OX=9913 GN=JOSD2 PE=4 SV=1 CANONICAL=A0AAA9T863-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9X7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#A0AAA9S9X7-1", "sequence": { "sequence": "MSQAPGAQPSPPSVYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRPLSQLALPRVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEVLGDEDGVRAFLAAALAQGLCEVLLVVTKEVEEQGSWLQAD", "length": 146, "header": "tr|A0AAA9S9X7-1|A0AAA9T863_BOVIN Computationally mapped isoform of Josephin-2 OS=Bos taurus OX=9913 GN=JOSD2 PE=4 SV=1 CANONICAL=A0AAA9T863-1" }, "locus": { "chromosome": "18", "start_pos": 56637487, "end_pos": 56634202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132005.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132005.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082881.1" } ] } }, { "isoform_ac": "A0AAA9T863-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#A0AAA9T863-1", "sequence": { "sequence": "MEPGGQQGPDPARDAWGLGFSPGVTRVPGTAGARAVLGVEGAPRRGEIGSWLAPDSRLNPHRSLLGTGNYDVNVIMAALQGQGLAAVWWDRRRPLSQLALPRVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEVLGDEDGVRAFLAAALAQGLCEVLLVVTKEVEEQGSWLQAD", "length": 190, "header": "tr|A0AAA9T863-1|A0AAA9T863_BOVIN Isoform 1 of Josephin-2 OS=Bos taurus OX=9913 GN=JOSD2 PE=4 SV=1 CANONICAL=A0AAA9T863-1" }, "locus": { "chromosome": "18", "start_pos": 56636208, "end_pos": 56634202, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104313.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104313.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092998.1" } ] } }, { "isoform_ac": "F1ME39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863/entry#F1ME39-1", "sequence": { "sequence": "MSQAPGAQPSPPSVYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRLAPDSRLNPHRSLLGTGNYDVNVIMAALQGQGLAAVWWDRRRPLSQLALPRVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGVYYNLDSKLRAPEVLGDEDGVRPQPPRVCAQGLPGGRAGSRFVRGAAGGNQGGGGAGLLAAGRLTPGGGAHGCPPGAAPETSLPSKRRGRGRTPRGLSGGPAPAPYAPPLPGLLPLLPQ", "length": 253, "header": "tr|F1ME39-1|F1ME39_BOVIN Computationally mapped isoform of Josephin-2 OS=Bos taurus OX=9913 GN=JOSD2 PE=4 SV=4 CANONICAL=A0AAA9T863-1" }, "locus": { "chromosome": "18", "start_pos": 56637487, "end_pos": 56634035, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008984.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008984.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008984.8", "url": "https://www.ensembl.org/id/ENSBTAP00000008984.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:112441489", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112441489", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689877", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689877", "resource": "Reactome", "description": "Josephin domain DUBs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T863", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-5688797", "name": "ATXN3 family cleave Ub chains", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T863-1" ], "evidence": [ { "id": "R-BTA-5688797", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5688797" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T863", "gene_name": "JOSD2", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T863" }, { "id": "PS50957", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50957" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Josephin", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 190, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7E4-1", "uniprot_ac": "A0AAA9T7E4", "uniprot_id": "A0AAA9T7E4_BOVIN", "mass": { "chemical_mass": 35649.0, "monoisotopic_mass": 35649.0 }, "refseq": {}, "gene_names": [ { "name": "RAET1G", "type": "recommended", "evidence": [ { "id": "A0AAA9T7E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4" } ] } ], "protein_names": [ { "name": "Retinoic acid early transcript 1G", "type": "synonym", "evidence": [ { "id": "A0AAA9T7E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAET1G", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4", "locus": { "chromosome": "9", "start_pos": 87183202, "end_pos": 87163668, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039329", "url": "https://www.ensembl.org/id/ENSBTAG00000039329" } ] } } ], "crossref": [ { "id": "A0AAA9T7E4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T7E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR011161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16675:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16675:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00129", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKGERGGPETRLGFLDLLLIVWFSGTPGDAHSLSFDFTVDPQPRPGHPWCEIQSQVDGKVFLSYDCGHAKIIIPSVLGEEVKTIKAWETQIETLRDIRDWIKDHMHDFTLEKHMPRDPRTLQARMTCHCEDDRHVSGSWQFGLNGQMSLHFDLENGHWRVGQPGGRWMKEKWENDRAVMEFLKKVSMGDCRGWLQDFMVRWKEILKTTASPTTVPPTVQPTAPPISHVTWIAPGVLVSFVIKGIVAWILYKKRRLCSQEAPDRCSVGLRTQCLLGCFCSPAFTLEPRDQTLGVSSLSTSYDDTVAAPSRVSCQI", "length": 315, "header": "tr|A0AAA9T7E4-1|A0AAA9T7E4_BOVIN Isoform 1 of Retinoic acid early transcript 1G OS=Bos taurus OX=9913 GN=RAET1G PE=4 SV=2 CANONICAL=A0AAA9T7E4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4/entry#A0AAA9T7E4-1", "sequence": { "sequence": "MAKGERGGPETRLGFLDLLLIVWFSGTPGDAHSLSFDFTVDPQPRPGHPWCEIQSQVDGKVFLSYDCGHAKIIIPSVLGEEVKTIKAWETQIETLRDIRDWIKDHMHDFTLEKHMPRDPRTLQARMTCHCEDDRHVSGSWQFGLNGQMSLHFDLENGHWRVGQPGGRWMKEKWENDRAVMEFLKKVSMGDCRGWLQDFMVRWKEILKTTASPTTVPPTVQPTAPPISHVTWIAPGVLVSFVIKGIVAWILYKKRRLCSQEAPDRCSVGLRTQCLLGCFCSPAFTLEPRDQTLGVSSLSTSYDDTVAAPSRVSCQI", "length": 315, "header": "tr|A0AAA9T7E4-1|A0AAA9T7E4_BOVIN Isoform 1 of Retinoic acid early transcript 1G OS=Bos taurus OX=9913 GN=RAET1G PE=4 SV=2 CANONICAL=A0AAA9T7E4-1" }, "locus": { "chromosome": "9", "start_pos": 87247560, "end_pos": 87236824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126744.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126744.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092677.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092677.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 27, "start_aa": "Thr", "end_pos": 27, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E4" }, { "id": "PF00129", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00129" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MHC class I-like antigen recognition-like", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 206, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 27 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T5E6-1", "uniprot_ac": "A0AAA9T5E6", "uniprot_id": "A0AAA9T5E6_BOVIN", "mass": { "chemical_mass": 70205.0, "monoisotopic_mass": 70205.0 }, "refseq": {}, "gene_names": [ { "name": "NF2", "type": "recommended", "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ] } ], "protein_names": [ { "name": "Merlin", "type": "recommended", "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#names_and_taxonomy" } ] }, { "name": "Moesin-ezrin-radixin-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#names_and_taxonomy" } ] }, { "name": "Neurofibromin-2", "type": "synonym", "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#names_and_taxonomy" } ] }, { "name": "Schwannomin", "type": "synonym", "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6", "locus": { "chromosome": "17", "start_pos": 68831686, "end_pos": 68758910, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013153", "url": "https://www.ensembl.org/id/ENSBTAG00000013153" } ] } } ], "crossref": [ { "id": "A0AAA9T5E6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T5E6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013153", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013153", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13194", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13194", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17186", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17186", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540479", "url": "https://www.ncbi.nlm.nih.gov/gene/540479", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540479", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540479", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PGMLANE", "url": "https://omabrowser.org/oma/group/PGMLANE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M7A4", "url": "https://www.orthodb.org/?gene=A0A3Q1M7A4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIG2", "url": "https://www.orthodb.org/?gene=E1BIG2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23281", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23281", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00769", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00769", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09379", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09379", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M7A4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7A4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2D1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T974", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T974", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T974-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T974-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIG2", "url": "https://www.uniprot.org/uniprotkb/E1BIG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIG2-1", "url": "https://www.uniprot.org/uniprotkb/E1BIG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKVPVPSAPCPSVSLSVASEVKRAD", "length": 603, "header": "tr|A0AAA9T5E6-1|A0AAA9T5E6_BOVIN Isoform 1 of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=2 CANONICAL=A0AAA9T5E6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M7A4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0A3Q1M7A4-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKPQAQGRRPICI", "length": 546, "header": "tr|A0A3Q1M7A4-1|A0A3Q1M7A4_BOVIN Computationally mapped isoform of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=2 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68820653, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077341.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077341.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066245.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066245.2" } ] } }, { "isoform_ac": "A0AAA9SHP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9SHP4-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKPQAQGRRPICI", "length": 549, "header": "tr|A0AAA9SHP4-1|A0AAA9T5E6_BOVIN Computationally mapped isoform of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=1 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68820653, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116802.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116802.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083255.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083255.1" } ] } }, { "isoform_ac": "A0AAA9SWX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9SWX2-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKLTLQSAKSRVAFFEEL", "length": 596, "header": "tr|A0AAA9SWX2-1|A0AAA9T5E6_BOVIN Computationally mapped isoform of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=1 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68830682, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127660.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127660.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087749.1" } ] } }, { "isoform_ac": "A0AAA9T2D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9T2D1-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKPQAQGRRPICI", "length": 508, "header": "tr|A0AAA9T2D1-1|A0AAA9T5E6_BOVIN Computationally mapped isoform of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=1 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68820653, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103284.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103284.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090789.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090789.1" } ] } }, { "isoform_ac": "A0AAA9T5E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9T5E6-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKVPVPSAPCPSVSLSVASEVKRAD", "length": 603, "header": "tr|A0AAA9T5E6-1|A0AAA9T5E6_BOVIN Isoform 1 of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=2 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68824890, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110653.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110653.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091779.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091779.2" } ] } }, { "isoform_ac": "A0AAA9T974-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9T974-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKPQAQGRRPICI", "length": 550, "header": "tr|A0AAA9T974-1|A0AAA9T974_BOVIN Computationally mapped isoform of NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=1 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68820653, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096917.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096917.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095248.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095248.1" } ] } }, { "isoform_ac": "A0AAA9TSU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#A0AAA9TSU5-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKLTLQSAKSRVAFFEEL", "length": 165, "header": "tr|A0AAA9TSU5-1|A0AAA9TSU5_BOVIN Computationally mapped isoform of NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=1 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68830682, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127715.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127715.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100129.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100129.1" } ] } }, { "isoform_ac": "E1BIG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6/entry#E1BIG2-1", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENKLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPLPAPLPPDMASFSLTGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALRLKERETALDMLHNENSDRGGGGSKHNTIKKPQAQGRRPICI", "length": 591, "header": "tr|E1BIG2-1|E1BIG2_BOVIN Computationally mapped isoform of Merlin OS=Bos taurus OX=9913 GN=NF2 PE=4 SV=4 CANONICAL=A0AAA9T5E6-1" }, "locus": { "chromosome": "17", "start_pos": 68820653, "end_pos": 68759181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017489.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017489.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017489.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017489.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540479", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540479", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480KT19-1", "protein_name": "Merlin", "gene_name": "NF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGTSSKHNTIKKLTLQSAKSRVAFFEEL", "length": 596 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7EV75-1", "protein_name": "Merlin", "gene_name": "Nf2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPVNPIPAPLPPDIPSFNIIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGTSSKHNTIKKSSPRQKTYLHLSPQSRLFPGILSVVMVLPSVILTHA", "length": 616 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P35240-1", "protein_name": "Merlin", "gene_name": "NF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL", "length": 595 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P46662-1", "protein_name": "Merlin", "gene_name": "Nf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPPPLPPDIPSFDIIADSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDVLHSESSDRGGPSSKHNTIKKLTLQSAKSRVAFFEEL", "length": 596 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q24564-1", "protein_name": "Moesin/ezrin/radixin homolog 2", "gene_name": "Mer", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSPFGSKKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL", "length": 635 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q63648-1", "protein_name": "Merlin", "gene_name": "Nf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "IASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERSRDEPERRVLHMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFDIIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHSEHSDSGTSSKHNTIKKPQAQGRRPICI", "length": 586 }, "evidence": [ { "id": "A0AAA9T5E6", "url": "https://omabrowser.org/oma/group/A0AAA9T5E6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "positive regulation of protein localization to early endosome", "id": "GO:1902966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of hippo signaling", "id": "GO:0035330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of organelle assembly", "id": "GO:1902115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902115", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of gliogenesis", "id": "GO:0014013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014013", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "positive regulation of early endosome to late endosome transport", "id": "GO:2000643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000643", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "hippo signaling", "id": "GO:0035329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035329", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "negative regulation of cell-cell adhesion", "id": "GO:0022408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022408", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "negative regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046426", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "negative regulation of cell growth involved in contact inhibition", "id": "GO:0060243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060243", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "Schwann cell proliferation", "id": "GO:0014010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "lens fiber cell differentiation", "id": "GO:0070306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070306", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 20, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5E6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 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"https://www.uniprot.org/uniprotkb/A0AAA9T5E6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T5E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5E6" }, { "id": "PS50057", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50057" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FERM", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 311, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T7E2-1", "uniprot_ac": "A0AAA9T7E2", "uniprot_id": "A0AAA9T7E2_BOVIN", "mass": { "chemical_mass": 38500.0, "monoisotopic_mass": 38500.0 }, "refseq": { "ac": "XP_003586456", "name": "early growth response protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586456" }, "gene_names": [ { "name": "EGR3", "type": "recommended", "evidence": [ { "id": "A0AAA9T7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ] }, { "name": "EGR3", "type": "synonym", "evidence": [ { "id": "XP_003586456", "database": 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"database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526233", "url": "https://www.ncbi.nlm.nih.gov/gene/526233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526233", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526233", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GEVEPMY", "url": "https://omabrowser.org/oma/group/GEVEPMY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVC9", "url": "https://www.orthodb.org/?gene=A0A3Q1LVC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BBZ7", "url": "https://www.orthodb.org/?gene=E1BBZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11928", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11928", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003586456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586456", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ7", "url": "https://www.uniprot.org/uniprotkb/E1BBZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BBZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPCAAWSPRGGRENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCSDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSMPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAAPVSLAPVVTTCA", "length": 349, "header": "tr|A0AAA9T7E2-1|A0AAA9T7E2_BOVIN Isoform 1 of Early growth response protein 3 OS=Bos taurus OX=9913 GN=EGR3 PE=3 SV=1 CANONICAL=A0AAA9T7E2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2/entry#A0A3Q1LVC9-1", "sequence": { "sequence": "MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYNQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCSDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSMPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAAPVSLAPVVTTCA", "length": 387, "header": "tr|A0A3Q1LVC9-1|A0A3Q1LVC9_BOVIN Computationally mapped isoform of Early growth response protein 3 OS=Bos taurus OX=9913 GN=EGR3 PE=3 SV=1 CANONICAL=A0AAA9T7E2-1" }, "locus": { "chromosome": "8", "start_pos": 69999893, "end_pos": 69997421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073967.1", "url": "https://www.ensembl.org/id/ENSBTAT00000073967.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059244.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059244.1" } ] } }, { "isoform_ac": "A0AAA9T7E2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2/entry#A0AAA9T7E2-1", "sequence": { "sequence": "MEPCAAWSPRGGRENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCSDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSMPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAAPVSLAPVVTTCA", "length": 349, "header": "tr|A0AAA9T7E2-1|A0AAA9T7E2_BOVIN Isoform 1 of Early growth response protein 3 OS=Bos taurus OX=9913 GN=EGR3 PE=3 SV=1 CANONICAL=A0AAA9T7E2-1" }, "locus": { "chromosome": "8", "start_pos": 69999323, "end_pos": 69997421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131687.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131687.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092522.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092522.1" } ] } }, { "isoform_ac": "E1BBZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2/entry#E1BBZ7-1", "sequence": { "sequence": "MWAANPREGGTKVPEVLDRRPLTRWNPPQRNFVPVPENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCSDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSMPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAAPVSLAPVVTTCA", "length": 372, "header": "tr|E1BBZ7-1|E1BBZ7_BOVIN Computationally mapped isoform of Early growth response protein 3 OS=Bos taurus OX=9913 GN=EGR3 PE=3 SV=3 CANONICAL=A0AAA9T7E2-1" }, "locus": { "chromosome": "8", "start_pos": 70001106, "end_pos": 69997421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025687.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025687.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025687.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025687.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526233", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526233", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RMA1-1", "protein_name": "Early growth response protein 3", "gene_name": "EGR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPCAAWSPRGGRENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGEVEAMYPALPPYSNCSDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAAPVSLAPVVTTCA", "length": 349 }, "evidence": [ { "id": "A0AAA9T7E2", "url": "https://omabrowser.org/oma/group/A0AAA9T7E2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P43300-1", "protein_name": "Early growth response protein 3", "gene_name": "Egr3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYNQMATENVMDIGLTNEKPNPELSYSSSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAPTVSLAPVVTTCA", "length": 387 }, "evidence": [ { "id": "A0AAA9T7E2", "url": "https://omabrowser.org/oma/group/A0AAA9T7E2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P43301-1", "protein_name": "Early growth response protein 3", "gene_name": "Egr3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYTQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTTTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKSEKGGAPSASSAPTVSLAPVVTTCA", "length": 387 }, "evidence": [ { "id": "A0AAA9T7E2", "url": "https://omabrowser.org/oma/group/A0AAA9T7E2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q06889-1", "protein_name": "Early growth response protein 3", "gene_name": "EGR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVVHYNQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAPPVSLAPVVTTCA", "length": 387 }, "evidence": [ { "id": "A0AAA9T7E2", "url": "https://omabrowser.org/oma/group/A0AAA9T7E2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell proliferation", "id": "GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "cellular response to fibroblast growth factor stimulus", "id": "GO:0044344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044344", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "endothelial cell chemotaxis", "id": "GO:0035767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035767", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "system development", "id": "GO:0048731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7E2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7E2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 237, "end_pos": 266, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 42, "end_pos": 44 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T6Q0-1", "uniprot_ac": "A0AAA9T6Q0", "uniprot_id": "A0AAA9T6Q0_BOVIN", "mass": { "chemical_mass": 72200.0, "monoisotopic_mass": 72200.0 }, "refseq": { "ac": "XP_024845424", "name": "polycomb protein SCMH1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845424" }, "gene_names": [ { "name": "SCMH1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0" } ] }, { "name": "SCMH1", "type": "synonym", "evidence": [ { "id": "XP_024845424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845424" } ] } ], "protein_names": [ { "name": "Polycomb protein SCMH1", "type": "recommended", "evidence": [ { "id": "A0AAA9T6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#names_and_taxonomy" } ] }, { "name": "Sex comb on midleg homolog 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T6Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#names_and_taxonomy" } ] }, { "name": "polycomb protein SCMH1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024845424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845424" } ] } ], "function": [ { "annotation": "Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.", "evidence": [ { "database": "UniProtKB", "id": "E1BBV6", "url": "https://www.uniprot.org/uniprotkb/E1BBV6#function" }, { "database": "UniProtKB", "id": "ARBA00059346", "url": "https://www.uniprot.org/uniprotkb/ARBA00059346#function" }, { "database": "UniProtKB", "id": "A0A3Q1MXS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXS7#function" }, { "database": "UniProtKB", "id": "A0A3Q1MZA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZA1#function" }, { "database": "UniProtKB", "id": "A0AAA9S7T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7T0#function" }, { "database": "UniProtKB", "id": "A0AAA9T6Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0#function" }, { "database": "UniProtKB", "id": "A0AAA9TLA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T6Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCMH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0", "locus": { "chromosome": "3", "start_pos": 105189644, "end_pos": 104965098, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001629", "url": "https://www.ensembl.org/id/ENSBTAG00000001629" } ] } } ], "crossref": [ { "id": "A0AAA9T6Q0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T6Q0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001629", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001629", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20105", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20105", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540926", "url": "https://www.ncbi.nlm.nih.gov/gene/540926", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038348", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038348", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047279", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047279", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047280", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047280", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047531", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047531", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12140", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12140", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4570464", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4570464", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8939243", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939243", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8943724", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024845424", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845424", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXS7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXS7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZA1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLM0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBV6", "url": "https://www.uniprot.org/uniprotkb/E1BBV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BBV6-1", "url": "https://www.uniprot.org/uniprotkb/E1BBV6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQPSVIDWNDVRKHKYGHLSESASQHQEATDILELGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 649, "header": "tr|A0AAA9T6Q0-1|A0AAA9T6Q0_BOVIN Isoform 1 of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0A3Q1MXS7-1", "sequence": { "sequence": "MCHKKLSIIDWNDVRKHKYGHLSESASQHQEATDILELGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 652, "header": "tr|A0A3Q1MXS7-1|A0AAA9T6Q0_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=2 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105023529, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084094.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084094.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060630.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060630.2" } ] } }, { "isoform_ac": "A0A3Q1MZA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0A3Q1MZA1-1", "sequence": { "sequence": "MQKSDPRKVIDWNDVRKHKYGHLSESASQHQEATDILELGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 653, "header": "tr|A0A3Q1MZA1-1|A0AAA9T6Q0_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105023438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066775.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066775.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061499.1" } ] } }, { "isoform_ac": "A0AAA9S7T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0AAA9S7T0-1", "sequence": { "sequence": "MQPSVIDWNDVRKHKYGHLSESASQHQEATDILELGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 529, "header": "tr|A0AAA9S7T0-1|A0AAA9T6Q0_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105046811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099945.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099945.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079353.1" } ] } }, { "isoform_ac": "A0AAA9SLM0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0AAA9SLM0-1", "sequence": { "sequence": "MQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 481, "header": "tr|A0AAA9SLM0-1|A0AAA9T6Q0_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105054656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125668.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125668.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083559.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083559.1" } ] } }, { "isoform_ac": "A0AAA9T6Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0AAA9T6Q0-1", "sequence": { "sequence": "MQPSVIDWNDVRKHKYGHLSESASQHQEATDILELGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 649, "header": "tr|A0AAA9T6Q0-1|A0AAA9T6Q0_BOVIN Isoform 1 of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105046811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091457.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091457.1" } ] } }, { "isoform_ac": "A0AAA9TLA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#A0AAA9TLA2-1", "sequence": { "sequence": "MQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 592, "header": "tr|A0AAA9TLA2-1|A0AAA9TLA2_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=1 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105054656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097072.1" } ] } }, { "isoform_ac": "E1BBV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6Q0/entry#E1BBV6-1", "sequence": { "sequence": "MLVCYSVLACESLWDLTCSIMGSPLGHFTWDKYLKETCSVPAPIHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSAEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIRIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPYPASDVNTEKPSIHSSTKTVLEHQPGQRGRKPGKKRGRTPKPLIPHPISTPSKSAEPLKFPKKRGPKPGSKRKPRTLLNPPPTSPTTSTPEPDTSTVPQDAATIPSSAIQAPTVCIYLNKNGSTGPHLDKKKVQQLPDHFGPARASMVLQQAVQACIDCAYHQKTVFSFLKQGHGGAVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLSTTEYSHSHDRYLPGETFALGNSLARSLEPHSDSMDSTLNPTNLVSTSQNLRNPGYRPLLPSCGLPLSTASAVRRLCSRGKLFRGTNHRREGEGARQVSFCPAGSDRRDASRLSGRDPSSWTVEDVMQFVREADPQFGPHADLFRKHEIDGKALLLLRSDTMMKYMGLKLGPALKLCYHIDRLKQGKF", "length": 663, "header": "tr|E1BBV6-1|E1BBV6_BOVIN Computationally mapped isoform of Polycomb protein SCMH1 OS=Bos taurus OX=9913 GN=SCMH1 PE=3 SV=3 CANONICAL=A0AAA9T6Q0-1" }, "locus": { "chromosome": "3", "start_pos": 105188605, "end_pos": 105061342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002134.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002134.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002134.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002134.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 338, "start_aa": "Thr", "end_pos": 338, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr338", "evidence": [ { "id": "", "database": "GlyGen", "url": 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"https://www.ensembl.org/id/ENSBTAG00000030784" } ] } } ], "crossref": [ { "id": "A0AAA9TAP3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07632", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07632", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13158", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13158", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13247", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13247", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515605", "url": "https://www.ncbi.nlm.nih.gov/gene/515605", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004148", "url": 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Classification" ] }, { "id": "IPR047239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46415:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46415:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16746", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16746", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TAP3", "url": 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"MYCCEVPQSLSTKSKTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNVLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASSEHDLSMAKYSRLPKKKENEKVKAEIVKEVAAARRKQHLSSLQYYCALNALQYRKRVAMMEPMLGFAHGQINFFKKGAEMFSQSMDGFLSSVADMVQSIQVELEVEAEKMRASQQELLSLDEAVYTPDFDVAAPQVNRNLIQKAGYLNLRNKTGLVSTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKAGIILQAESRKENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFAKKQESPCPSQNVKSSEMENDKIVPKATVTIPEAEQLIAPGTPIQFDIVLPATEFLDQNRGGRRTNPFGETEDATFPEAEDSLLQQMFIVRFLGSMAVKTDNTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQTLRLIDPQTQVTRANFELTSVTQFAAHQENKRLVGFVVRLPESTGGESLSTYVFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSVPLTNDGKYVLLNDQPDDNDGSPSENRGAESEA", "length": 659, "header": "tr|A0AAA9TAP3-1|A0AAA9TAP3_BOVIN Isoform 1 of DCC-interacting protein 13-beta OS=Bos taurus OX=9913 GN=APPL2 PE=4 SV=1 CANONICAL=A0AAA9TAP3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3/entry#A0AAA9TAP3-1", "sequence": { "sequence": 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"ENSBTAT00000135842.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135842.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095780.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095780.1" } ] } }, { "isoform_ac": "F6QYL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3/entry#F6QYL9-1", "sequence": { "sequence": "MPAVDKLLLEEALQDSPQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNVLHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASSEHDLSMAKYSRLPKKKENEKVKAEIVKEVAAARRKQHLSSLQYYCALNALQYRKRVAMMEPMLGFAHGQINFFKKGAEMFSQSMDGFLSSVADMVQSIQVELEVEAEKMRASQQELLSLDEAVYTPDFDVAAPQVNRNLIQKAGYLNLRNKTGLVSTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKAGIILQAESRKENEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFAKKQESPCPSQNVKSSEMENDKIVPKATVTIPEAEQLIAPGTPIQFDIVLPATEFLDQNRGGRRTNPFGETEDATFPEAEDSLLQQMFIVRFLGSMAVKTDNTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQTLRLIDPQTQVTRANFELTSVTQFAAHQENKRLVGFVVRLPESTGGESLSTYVFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSVPLTNDGKYVLLNDQPDDNDGSPSENRGAESEA", "length": 629, "header": "tr|F6QYL9-1|F6QYL9_BOVIN Computationally mapped isoform of DCC-interacting protein 13-beta OS=Bos taurus OX=9913 GN=APPL2 PE=4 SV=1 CANONICAL=A0AAA9TAP3-1" }, "locus": { "chromosome": "5", "start_pos": 68753033, "end_pos": 68702367, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043505.3", "url": "https://www.ensembl.org/id/ENSBTAT00000043505.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041069.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041069.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "regulation of fibroblast migration", "id": "GO:0010762", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010762", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of fatty acid oxidation", "id": "GO:0046322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046322", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "protein homotetramerization", "id": "GO:0051289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "diet induced thermogenesis", "id": "GO:0002024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "cold acclimation", "id": "GO:0009631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "adiponectin-activated signaling pathway", "id": "GO:0033211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of cytokine production involved in inflammatory response", "id": "GO:1900016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis, engulfment", "id": "GO:0060100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060100", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of neurogenesis", "id": "GO:0050768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis", "id": "GO:1905451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905451", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "cellular response to hepatocyte growth factor stimulus", "id": "GO:0035729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "regulation of G1/S transition of mitotic cell cycle", "id": "GO:2000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000045", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of neural precursor cell proliferation", "id": "GO:2000178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "protein import into nucleus", "id": "GO:0006606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006606", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "regulation of toll-like receptor 4 signaling pathway", "id": "GO:0034143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034143", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of D-glucose import", "id": "GO:0046325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "negative regulation of cellular response to insulin stimulus", "id": "GO:1900077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900077", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "positive regulation of macropinocytosis", "id": "GO:1905303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "homeostatic process", "id": "GO:0042592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042592", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "macropinosome", "id": "GO:0044354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044354", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "early phagosome membrane", "id": "GO:0036186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" }, { "name": "phagocytic vesicle membrane", "id": "GO:0030670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030670", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP3", "url": 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"url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207881" } ] } ], "protein_names": [ { "name": "Protocadherin 7", "type": "synonym", "evidence": [ { "id": "A0AAA9TAV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#names_and_taxonomy" } ] }, { "name": "protocadherin-7 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005207881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207881" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6", "locus": { "chromosome": "6", "start_pos": 50427483, "end_pos": 49957890, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000061", "url": "https://www.ensembl.org/id/ENSBTAG00000000061" } ] } } ], "crossref": [ { "id": "A0AAA9TAV6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAV6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000061", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000061", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514537", "url": "https://www.ncbi.nlm.nih.gov/gene/514537", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514537", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514537", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NN74", "url": "https://www.orthodb.org/?gene=A0A3Q1NN74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BCK4", "url": "https://www.orthodb.org/?gene=E1BCK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF253", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF253", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005207881", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN74", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN74-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUS4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T501", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T501", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T501-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T501-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCK4", "url": "https://www.uniprot.org/uniprotkb/E1BCK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCK4-1", "url": "https://www.uniprot.org/uniprotkb/E1BCK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENDSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKNEDANTEDIPLTKTGEYKPSPVNTLTRREVYL", "length": 1257, "header": "tr|A0AAA9TAV6-1|A0AAA9TAV6_BOVIN Isoform 1 of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NN74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0A3Q1NN74-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENGVAAITTFPFLPFPHGKTHGRRVLLRPLH", "length": 1161, "header": "tr|A0A3Q1NN74-1|A0AAA9TAV6_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=2 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50211268, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075153.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075153.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074162.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074162.2" } ] } }, { "isoform_ac": "A0AAA9RUS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0AAA9RUS4-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSAAPFQGTADSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKNEDANTEDIPLTKTGEYKPSPVNTLTRREVYL", "length": 1230, "header": "tr|A0AAA9RUS4-1|A0AAA9TAV6_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50426479, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103200.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103200.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075944.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075944.1" } ] } }, { "isoform_ac": "A0AAA9RZD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0AAA9RZD2-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG", "length": 1071, "header": "tr|A0AAA9RZD2-1|A0AAA9TAV6_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 49967440, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117478.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117478.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078952.1" } ] } }, { "isoform_ac": "A0AAA9SRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0AAA9SRL1-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQVDTVQTTKPPGHIEESCKMNPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENDSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKNEDANTEDIPLTKTGEYKPSPVNTLTRREVYL", "length": 1277, "header": "tr|A0AAA9SRL1-1|A0AAA9TAV6_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50426479, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090677.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090677.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086702.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086702.1" } ] } }, { "isoform_ac": "A0AAA9T501-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0AAA9T501-1", "sequence": { "sequence": 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"length": 1067, "header": "tr|A0AAA9T501-1|A0AAA9TAV6_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50426126, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130074.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130074.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092899.1" } ] } }, { "isoform_ac": "A0AAA9TAV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#A0AAA9TAV6-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVGEAEHMENDSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKNEDANTEDIPLTKTGEYKPSPVNTLTRREVYL", "length": 1257, "header": "tr|A0AAA9TAV6-1|A0AAA9TAV6_BOVIN Isoform 1 of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=1 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50426479, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095131.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095131.1" } ] } }, { "isoform_ac": "E1BCK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6/entry#E1BCK4-1", "sequence": { "sequence": "MLRMRTMGWARAWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGGGGGGEGRRAGPADSAPYPGGGGNGGSGGGPGGSKRRLDAPEAGGGTSPGGRSSVFELQVADTPDGEKQPQLIVKGSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTMLDREQTDRYEFKVNARDKGVPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDSTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATVIDSQIARSLHTPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQPFRRVTFSVVSQPQDPHQGSLQSCYDSGLEESETPSSKSSSGPRLGALPLPEDNYERTTPDGSVDSRPLPDVALTGKCTRECDEYGHSDSCWMPVRTSPERKKSQPKLSTFMPVDERGSQEKLANGEAAIMGDRNRNLLNKKLTSSYETFSAASFSKNEDANTEDIPLTKTGEYKPSPVNTLTRREVYL", "length": 1203, "header": "tr|E1BCK4-1|E1BCK4_BOVIN Computationally mapped isoform of Protocadherin 7 OS=Bos taurus OX=9913 GN=PCDH7 PE=4 SV=2 CANONICAL=A0AAA9TAV6-1" }, "locus": { "chromosome": "6", "start_pos": 50426479, "end_pos": 49958089, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000069.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000069.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000069.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000069.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514537", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514537", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1038, "end_pos": 1040, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1132, "end_pos": 1134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" }, { "start_pos": 782, "end_pos": 784, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" }, { "start_pos": 824, "end_pos": 826, "annotation": "n_glycosylation_sequon" }, { "start_pos": 842, "end_pos": 844, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAV6", "database": "UniProtKB", "url": 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{ "start_pos": 847, "end_pos": 849 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCJ6-1", "uniprot_ac": "A0AAA9TCJ6", "uniprot_id": "A0AAA9TCJ6_BOVIN", "mass": { "chemical_mass": 554996.0, "monoisotopic_mass": 554996.0 }, "refseq": { "ac": "XP_024833372", "name": "bridge-like lipid transfer protein family member 1 isoform X6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833372" }, "gene_names": [ { "name": "BLTP1", "type": "recommended", "evidence": [ { "id": "A0AAA9TCJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6" } ] }, { "name": "BLTP1", "type": "synonym", "evidence": [ { "id": "XP_024833372", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833372" } ] } ], "protein_names": [ { "name": "Bridge-like lipid transfer protein family member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TCJ6", "database": "UniProtKB", "url": 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"crossref": [ { "id": "ENSBTAG00000048798", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100297914", "url": "https://www.ncbi.nlm.nih.gov/gene/100297914", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033616", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033616", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR31640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31640:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31640:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF20413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20413", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024833372", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833372", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLH9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9E6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9E6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S792", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S792", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S792-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S792-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T539", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T539", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T539-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T539-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQLEDFPTSPTSTAKQEFLTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYGMKDSATSPPSPPLPCTVQSKTNTLLPPQPPPIPSAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQLLDAAHHRHWPGVLKVVSGCHISLFQIPLPEDGMQFGGSMSLHGNHMTLACFHGPNFRSKSWALFHLEEPNIAFWTEAQKIWEDGSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 5002, "header": "tr|A0AAA9TCJ6-1|A0AAA9TCJ6_BOVIN Isoform 1 of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=1 CANONICAL=A0AAA9TCJ6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6/entry#A0A3Q1LLH9-1", "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTLKKTVWGSAPQSSCPGEGYFQFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQCSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 4887, "header": "tr|A0A3Q1LLH9-1|A0AAA9TCJ6_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=2 CANONICAL=A0AAA9TCJ6-1" }, "locus": { "chromosome": "17", "start_pos": 35505549, "end_pos": 35321751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078645.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078645.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060626.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060626.2" } ] } }, { "isoform_ac": "A0A3Q1M9E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6/entry#A0A3Q1M9E6-1", "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTLKKTVWGSAPQSSCPGEGYFQFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQLLDAAHHRHWPGVLKVVSGCHISLFQIPLPEDGMQFGGSMSLHGNHMTLACFHGPNFRSKSWALFHLEEPNIAFWTEAQKIWEDGSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 4971, "header": "tr|A0A3Q1M9E6-1|A0AAA9TCJ6_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=2 CANONICAL=A0AAA9TCJ6-1" }, "locus": { "chromosome": "17", "start_pos": 35505549, "end_pos": 35321751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071481.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071481.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070593.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070593.2" } ] } }, { "isoform_ac": "A0AAA9S792-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6/entry#A0AAA9S792-1", "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTSSDGSAVSGDGHKLTFGQRLVNHLLGLRPPHQRYSVPAEYLCDPDMWASPQSSQSHLKACRAHSWGNEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTLKKTVWGSAPQSSCPGEGYFQFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQLLDAAHHRHWPGVLKVVSGCHISLFQIPLPEDGMQFGGSMSLHGNHMTLACFHGPNFRSKSWALFHLEEPNIAFWTEAQKIWEDGSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 5038, "header": "tr|A0AAA9S792-1|A0AAA9TCJ6_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=1 CANONICAL=A0AAA9TCJ6-1" }, "locus": { "chromosome": "17", "start_pos": 35505549, "end_pos": 35321751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109176.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109176.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078034.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078034.1" } ] } }, { "isoform_ac": "A0AAA9T539-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6/entry#A0AAA9T539-1", "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQLEDFPTSPTSTAKQEFLTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTSSDGSAVSGDGHKLTFGQRLVNHLLGLRPPHQRYSVPAEYLCDPDMWASPQSSQSHLKACRAHSWGNEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTLKKTVWGSAPQSSCPGEGYFQFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYGMKDSATSPPSPPLPCTVQSKTNTLLPPQPPPIPSAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQLLDAAHHRHWPGVLKVVSGCHISLFQIPLPEDGMQFGGSMSLHGNHMTLACFHGPNFRSKSWALFHLEEPNIAFWTEAQKIWEDGSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 5090, "header": "tr|A0AAA9T539-1|A0AAA9TCJ6_BOVIN Computationally mapped isoform of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=1 CANONICAL=A0AAA9TCJ6-1" }, "locus": { "chromosome": "17", "start_pos": 35505549, "end_pos": 35321751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116815.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116815.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092941.1" } ] } }, { "isoform_ac": "A0AAA9TCJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6/entry#A0AAA9TCJ6-1", "sequence": { "sequence": "MDQRKNESIVPSITQLEDFLTEHNSNVVWLLVATILSCGWIIYLTYYNSRNVGLILTLVLNRLYKRGYIHIGSFSFSVLSGKVMVREIYYITEDMSIRIQDGFIIFRWWKMYNPKQKQHDPKAETRLYITVNDFEFHVYNRSDLYGHLQELFGLEPTIIPPKKEDDKTRENGRTRTQSKIERVKVKTESQDPTSSWRSLIPVIKVNVSTGRLAFGNHYQPQTLCINFDDAFLTYTTKPPSSHLDQFMHIVKGKLENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEETEENVEGEMSTEDCKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRDCLWKFFFPPDYQVLKVSEIAQPGRPRQILAFELRMNIIADATIDLLFTKNRETNAVHVNVGAGSYLEINIPMTVEENGYTPAIKGQLLHVDATTSMQYRTLLEAEMLAFHINASYPRIWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWSSDSAPDIFSFVPYTWNFKIMFHQFEMIWAANQHNWIDCSTKQQENVYLAACGETLNIDFSLPFTDFVPATCNTKFSLKGEDVDLHLFLPDCHPSKYSLFMLVKNCHPNKMTHDTGIPAECQSGQKTVKPKWRNITQEKAGWVECWTVPSVMLTIDYTWHPIYPQKADEQLKQSLSEMEETMLSVLRPSQKTDRVVSSPSTSSRPPIDPSELPPDKLHVEMELSPDSQITLYGPLLNAFLCIKENYFGEDDMYMDFEEVISSPVLSLSTSSSSGWTAVGMENDKKENESSAKSIHPLTLRPWDITVLVNLYKVHGRLPVHGTTDGPECPTAFLERLCFEMKKGFRETMLQLVLSPLNVFVSDNYQQRPPVDEVLREGHINLSGLQLRAHAMFSAEGLPLGSDSLEYAWLIDVQAGSLTAKVTAPQLACLLEWGQIFIFHVVCREYELERPKSVVVCQHGIDRRFCESKLSCISGPCPTSDDLKYTMTRLAVDGADIYIVEHGCATNIKMGAIRVANCNLHNQSVGEGISAAIQDFQVRQYIEQLNNSRVGLQPAVLRRAYWLEAGSANLGLITVDIALAADHHSKHEAQRHFLETHDARTKRLWFLWPDDTLKNKRCKNKCGCLGGCRFFGGTVTGLDFFKLEELTPSSSSAFSSTSAESDMYYGQSLLQPGEWIITKEVPKIVDGNVNGIKRKEWENKSVGIEVERKTQHLSLQVPLRSHSSSSSSEENSSSSAAQPLLAGEKESPSSVADDHLVQKEFLHGTKRDDGQASIPTEISGNSPVSPNTQEKSVGQSPLRSPLKRQASVCSTRLGSTKSLTAAFYGDKQPVTVGVQFSSDVSRSDENVLDSPKQRRSFGSFPYTPSADSNSFHQYRSMDSSMSMADSEAYFSAAEEFEPISSDEGPGTYPGRKKKRKQAQQIDYSRGSIYHSVEGPLTGQGENIQDPRTLPFKTHPSQASFVSALGGEDDVIEHLYVVESEKTIESEQITSQQPVMNCYQTYLTQFQVINWSVKHPTNKRTSKSSLHRPLDLETPTSEESSSSFEQLSVPTFKVIKQGLTANSLLDRGIQLSGSTSNTPYTPLEKKAVDNTDDETLTEEWTLDQPVSQTRTTAIVEVKGTVDIVLTPLVAEALDRYIEAMVHCASTRHPAAIVDDLHVKVLREAVQNSKTTFSENLSSKQDVRGTKTEHCTIGMTNQGQAQTNPIMKQDNVTIKGLQANVSIPKVNLCLLQASVEESPNTAPSRSVTHVSLVALCFDRIATQVRMNRGVVEESSNSADPGRTSNFDRYVHATKMQPQSSGSLRSNAGVEKGKEIAAKLNIHRVHGQLRGLDTTDIGTCAITAIPFEKSKVLFTLEELDEFAFVDETDQQAVPDVTRIGPSQEKWGWIMFECGLENLTIKGGRQSGAVLYNAFGIMGKANVTERGGVLTSNNSSDSPTGSGYNTDVSDDNLPCDRTSPSSDLNGNSVSDEQDEGVESDDLKKDLPLMPPPPDSCSMKLTIKEIWFSFAAPTNVRSPAHAFSRQLNLLSTATPAVGAWLVPIDQLKSSLNKLETEGTLRICAVMGCIMTEALENKSVHFPLRSKYNRLTKVARFLQENPSCLLCNILHHYLHQANYSIIDEATMSDGLPALVTLKKGLVALARQWMKFIVVTPAFKGVSLHRPAQSLKPQSAVDHEHEDGLGLDNGGGLQSDTSADGAEFEFDAATVSEHTMLLEGTANRPPPGSSGPVTGAEIMRKLSKTHTHSDSALKIKGIHPYHSLSYTSGDTATDSPVHVGRAGVPVKESPRKESLLSYLTGSFPSLHNLLEGTPQRSSAAVKSSSLTRTGNTMASDMLSEHPLLSEPSSVSFYNWMSNAVGNRGSVVQESPVTKSGHNSLPTGVAPNLPTIPSASDFNTVLSSDQNTLDGTHSQHSTSQDDVAGVEEANQGFPAVQLADAQVVFKPLLSHTGIQSQDAMPLCYRMYFGEHLSFSGTLDCLRADIVDSDTAKERKGKRARRQGHVNLPPLEFKPALMLETFSISAVVMEKSVCTPQNSTNALSFHDLNKRYYNTFHCNFTISCQSISQHVDMALVRLIHQFSTMIDDIKATQTDIKLSRYTAGSASPTPTFKTRKHRDFRSSDFSRSSRGSLNGGNRVNNTKNKRTNNENNKKESRNKNSLGRSERRTSKVSRKGSKDVVDHMTIHMDDSDSITVSEQSEPSAECWQNMYKLLNFYSLISDPTGILEKSSETFGPAGVRSPTEPTCKVVFENEQDNTSVTKRKRSLVTAEPQHVTLIVFGIGMVNRTHLEADIGGLTMESELKRIHGSFTLKEKMKDVLHQKMTETCATAHIGGVNIVLLEGITPNIQLEDFPTSPTSTAKQEFLTVVKCSIAKSQALYSAQRGLKTNNAAVFKVGAISINIPQHPATLHSMMVRSSHQLSKQISDLIRQPSTAPQPVKEDIATPLPSEKTPTSVNQTPIETNEFPQLPEGLEKKPIVLKFSAMLDGIAIGAALLPSLKAEYKMGRMRSHGMTGAQTRFTFELPNHRLRFTSKVSATDMSTIPPSASLNLPPVTMSGKYIMEEHDSYSDQVWSIDELPSKQGYYLQGNYLRCVAEVGSFEHNLTTDLLNHLVFVQKVFMKEVNEVIQKVSGGEQPIPLWNEHDGTADGEKPKILLYSLNLQFKGIQVTATTPSMRAVRFETGLIELELSNRLQTKASPGSSSYLKLFGKCQVDLNLALGQIVKHQVYEEAGSDFHQVAYFKTRIGLRNALREEISGSSDREAVLITLNRPIVYAQPVAFDRAVLFWLNYKAAYDNWNEQRMALHKDIHMATKEVVDMLPGIQQTSAQAFGTLFLQLTVNDLGICLPITNTAQSNHTGDLDTGSALVLTIESTLITACSSESLVSKGHFKNFCIRFADGFETSWDDWKPEIRGDLVMNACVVPDGTYEVCSRTTGQAAAESSSAGTWTLNVLWKMCGIDVHMDPNIGKRLNALGNTLTTLTGEEDIDDIADLNSVNIADLSDEDEVDTMSPTIHTEAVDYRRQGASGSQPGELRGRKIMKRIVDIRELNEQAKVIDDLKKLGASEGTINQEIQRYQQLESVAVNDIRRDVRKKLRRSSMRAASLKDKWGLGYKPSYSRSKSISASGRPPLKRMERASSRVGETEELPEIRVDAASPGPRVTFNIQDTFPEETELDLLSVTIEGPSHYSSNSEGSYSMFSSPKTPGGFSPGISFQSEEGRRDDSLSSTSEDSEKDEKDDDHERERFYIYRKPSHTSRKKATGFAAVHQLFTERWPTAPANRSLSGTATERNIDFELDIRVEIDSGKCVLHPTTLLQEHDDISLRRSYDRSSRSLDQESPSKKKKFQTNYASTTHLMTGKKVPSSLQTKPSDLETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKESKLYGMKDSATSPPSPPLPCTVQSKTNTLLPPQPPPIPSAKGKGSGGVKTAKLYAWVALQSLPEEMVISPCLLDFLEKALETIPITPVERNYTTVSSQDEDMGHFEIPDPMEESTTSLVSSSTSAYSSFPVDVVVYVRVQPSQIKFSCLPVSRVECMLKLPSLDLVFSSNRGELETLGAAYPAETLSPGGSAPPSGTKTSSSKTGVPGSSGLGSPLGRSRHSSSQSDLTSSSSSSSGLSFTACMSDFSLYVFHPYGAGKQKTAVSGLTPGSGGLGNVDEEPTSVTGRKDSLSINLEFVKVSLSRIRRSGGASFFESQSVSKSASKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARRLFLGDQTINLPTSGPGTPDSIEGVSQHLSPESSRKAYCRTWEQPSQSASFTHMPQSPNVFSEHMTNSTMSPGTAAQSLKSPASIRSRSVSDSSVPRRDSLSKTSTPFNKSNKAASQQGTPWETLVVFAINLKQLNVQMNMSNVMGNTTWTTSGLKSQGRLSVGSNRDREISMSVGLGRSQLDSKGGVVGGTIDVNALEMVAHISEHPNQQPSHKIQITMGSTEARVDYMGSSILMGIFSNADLKLQDEWKVNLYNTLDSSMTDKSEIFVHGDLKWDIFQVMISRSTTPDLIKIGMKLQEFFTQQFDTSKRALSTWGPVPYLPPKTMTNNLEKSSQEQLLDAAHHRHWPGVLKVVSGCHISLFQIPLPEDGMQFGGSMSLHGNHMTLACFHGPNFRSKSWALFHLEEPNIAFWTEAQKIWEDGSNDHSTYIVQTLDFHLGHNTMVTKPCGALESPMATITKITRRRHENPPHGVASVKEWFNYVTATRNEELNLLRNVDANNTENSTTVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQEPSLQDASLKPKVECSVVTEFTDHICVTMDAELIMFLHDLVSAYLKEKEKAIFPPRILSTRPGQKSPVIIHDENSSDKDREDSITYTTVDWRDFMCKTWHLEPTLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGTALQDEKEKKGKDKEEH", "length": 5002, "header": "tr|A0AAA9TCJ6-1|A0AAA9TCJ6_BOVIN Isoform 1 of Bridge-like lipid transfer protein family member 1 OS=Bos taurus OX=9913 GN=BLTP1 PE=4 SV=1 CANONICAL=A0AAA9TCJ6-1" }, "locus": { "chromosome": "17", "start_pos": 35505549, "end_pos": 35321751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095601.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095601.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095776.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095776.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2604, "start_aa": "Thr", "end_pos": 2604, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2604", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3993, "start_aa": "Thr", "end_pos": 3993, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3993", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "synaptic vesicle endocytosis", "id": "GO:0048488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048488", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1026, "end_pos": 1028, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1050, "end_pos": 1052, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1203, "end_pos": 1205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1235, "end_pos": 1237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1513, "end_pos": 1515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1678, "end_pos": 1680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1713, "end_pos": 1715, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1722, "end_pos": 1724, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1898, "end_pos": 1900, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1922, "end_pos": 1924, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1933, "end_pos": 1935, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1934, "end_pos": 1936, "annotation": "n_glycosylation_sequon" }, { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2075, "end_pos": 2077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2116, "end_pos": 2118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2533, "end_pos": 2535, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2554, "end_pos": 2556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2635, "end_pos": 2637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2752, "end_pos": 2754, 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"id": "A0AAA9RXI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6L8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMKILMPRPVLLLEIPWNQEKDRKLSAVKEKRRKENICPGCSLEGLMLKLKLQYFGHLMRRADSFEKTLMLGKIEGRRRRGQPRMRCLDGITDSVDILSRKNVRHNAKCWLCSGGKTDKVSSFMNLFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 435, "header": "tr|A0AAA9TBP4-1|A0AAA9TBP4_BOVIN Isoform 1 of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0A3Q1LMQ1-1", "sequence": { "sequence": "MEHLVNQKYGTSHCRPRALGYFSYIAEIPFTGKFLNILVLTFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 350, "header": "tr|A0A3Q1LMQ1-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=2 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82242715, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073011.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073011.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058003.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058003.2" } ] } }, { "isoform_ac": "A0A3Q1LQE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0A3Q1LQE9-1", "sequence": { "sequence": "MASLTQWTHNAKCWLCSGGKTDKVSSFMNLFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 339, "header": "tr|A0A3Q1LQE9-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=2 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82237794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077803.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077803.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062404.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062404.2" } ] } }, { "isoform_ac": "A0A3Q1MGN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0A3Q1MGN9-1", "sequence": { "sequence": "MLSFYWMNVLVTRHKKYCLCLVCIYELTDVPSLKKQIHFLMGRKILFSFSLIFLCIGFSLTLDQILSRKNVSFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 381, "header": "tr|A0A3Q1MGN9-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82240252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070513.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070513.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068194.1" } ] } }, { "isoform_ac": "A0AAA9RXI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0AAA9RXI6-1", "sequence": { "sequence": "MASLTQWTFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 317, "header": "tr|A0AAA9RXI6-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82237794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092647.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092647.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078220.1" } ] } }, { "isoform_ac": "A0AAA9SDQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0AAA9SDQ2-1", "sequence": { "sequence": "MLGGIGGRRRRGRQRMRWLNGITDSMDLQNDSENHDFFLSQIWHNAKCWLCSGGKTDKVSSFMNLFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 374, "header": "tr|A0AAA9SDQ2-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82224687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103810.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103810.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081704.1" } ] } }, { "isoform_ac": "A0AAA9SEQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0AAA9SEQ9-1", "sequence": { "sequence": "MASLTQWTKNVRHNAKCWLCSGGKTDKVSSFMNLFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 343, "header": "tr|A0AAA9SEQ9-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82237794, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083882.1" } ] } }, { "isoform_ac": "A0AAA9T6L8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0AAA9T6L8-1", "sequence": { "sequence": "MASRTRWTFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 317, "header": "tr|A0AAA9T6L8-1|A0AAA9TBP4_BOVIN Computationally mapped isoform of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82224745, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094405.1" } ] } }, { "isoform_ac": "A0AAA9TBP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4/entry#A0AAA9TBP4-1", "sequence": { "sequence": "MMKILMPRPVLLLEIPWNQEKDRKLSAVKEKRRKENICPGCSLEGLMLKLKLQYFGHLMRRADSFEKTLMLGKIEGRRRRGQPRMRCLDGITDSVDILSRKNVRHNAKCWLCSGGKTDKVSSFMNLFISRTSSNQEVVVNSDRQNSGDVKPVQNFTVMPITQALNYNLSRRLEKEPWNAFSHHSPVNVSMDGIPCILFWAKRITIKFKNQTWLDLTDEAIGQKATVDAGNSNCSEESAMLSLKFGDAENPRGLDIRFTLTSYKLSIQRWYSLHRVEVIFNNSIQATFNATGIYAPSSYSYHCQRVSSLQAYDALLLPSDTNDMSSLWEVTFVDFQIQGFPIKGGQFAKARDCTSSFSPAILIGLVMSLLLLLVLAYALHMLIYLRYLDRHYDLIASPAHFPQLTSQDTAEEKELLRSQGAECYELRSQQICKIYV", "length": 435, "header": "tr|A0AAA9TBP4-1|A0AAA9TBP4_BOVIN Isoform 1 of ATPase H+ transporting accessory protein 1 like OS=Bos taurus OX=9913 GN=ATP6AP1L PE=3 SV=1 CANONICAL=A0AAA9TBP4-1" }, "locus": { "chromosome": "7", "start_pos": 82260599, "end_pos": 82236768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131151.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131151.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094269.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QDB0-1", "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGRKLLFSFSLLFLCMLFAATLDQILARKNVGSQASSSKEVIIRSGQENSGEVKPVQNFTIPITQTFNYNLSKTLWSTFSHHNPVKFSRDGVPCILFWTKRITVKFKNQTWLDLTDEAPGQNTTVDTGNSNCNEESAMLSLRFGDAENPKDIDIRLTLTNYNKLSSQSWFSLHRVEIIFNNSVQASFNATGIYALSSYSYRCQRVSSLRRNDALMLLSSSDDVTSLWEVTFIDFQIQGFSIKGAQFAQARDCGSAFSPAVLIGLAMSLILLLVLAYALHMLIYLRYLDRHYEFITSPAHFPPLRELDTGEEKELLGSQGAECYELRSQQICKIYI", "length": 335 }, "evidence": [ { "id": "A0AAA9TBP4", "url": "https://omabrowser.org/oma/group/A0AAA9TBP4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3Z5W0-1", "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKLLFSFSLLFLCMVFSVSLDQILARKNVGSQESSSKEVVVRNGQKNSGEVKPVQNFTRIPIAQTFNYNLSNKPWSTFSHHNPVQFSRDGIPCILFWTKRITVKFKNQTWLDLTDEALGQNTTVDTGNSNCSEESATLSLKFGDDEDPKDIDIRFTLTNYNKLASQSWFSLHRVEIIFNNSVQATFNATGIYALSTYSYRCQRVSSLRRNDALLLLSSSDDVTSLWEVTFIDFQIQGFSIKGAQFAQARDCSSSFSPAILIGLAMSLILLLVLAYALHMLIYLRYLDRHYEFITSPDHFPSLRALDTGEEKELLGSQGAECYELRNQQICKIYI", "length": 336 }, "evidence": [ { "id": "A0AAA9TBP4", "url": "https://omabrowser.org/oma/group/A0AAA9TBP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZA00-1", "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRKLLFSFSLLFLCMVFSVSLDQILARKNVGSQASSSKEAIVPNGQRNSGEVKPVQNLTTVPITQTFNYNLSKAHWSTFSHHNPVKFSRDGIPCILFWTKRITVKFKNQTWLDLTDEALGQNTTVDTGNSNCSEENAVIKQMRKSKHRLWRTVRLSLKFGDAENPKDIDIRFTLSNYIKLSSQSWFSLHRVEIIFNNSVQATFNATGIYALSTYSYHCQRVSSLRRNDALLLLSSSDDVTSLWEVTFIDFQIQGFSIKGAQFSQARDCSSSFSPAVLIGLAMSLILLLVLAYALHMLIYLRYLDHHYEFITSPAHFPSLRALDIGEEKELLGSQGAECYELRNQQICKIYI", "length": 352 }, "evidence": [ { "id": "A0AAA9TBP4", "url": "https://omabrowser.org/oma/group/A0AAA9TBP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" } ], "pmid": "" }, { "name": "bounding membrane of organelle", "id": "GO:0098588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098588", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" } ], "pmid": "" }, { "name": "proton-transporting V-type ATPase complex", "id": "GO:0033176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033176", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of cellular pH", "id": "GO:0030641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030641", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": 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"uniprotkb_annotation": "V-type proton ATPase subunit S1 luminal", "eco_id": "ECO_0000259", "start_pos": 194, "end_pos": 339, "start_aa": "Pro", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBP4" }, { "id": "PF20520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "V-type proton ATPase subunit S1/VOA1 transmembrane", "eco_id": "ECO_0000259", "start_pos": 355, "end_pos": 392, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 232, "end_pos": 234 }, { "start_pos": 280, "end_pos": 282 }, { "start_pos": 288, "end_pos": 290 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TA72-1", "uniprot_ac": "A0AAA9TA72", "uniprot_id": "A0AAA9TA72_BOVIN", "mass": { "chemical_mass": 40517.0, "monoisotopic_mass": 40517.0 }, "refseq": {}, "gene_names": [ { "name": "WDR73", "type": "recommended", "evidence": [ { "id": "A0AAA9TA72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72" } ] } ], "protein_names": [ { "name": "WD repeat domain 73", "type": "synonym", "evidence": [ { "id": "A0AAA9TA72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72", "locus": { "chromosome": "21", "start_pos": 22302091, "end_pos": 22316313, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001387", "url": "https://www.ensembl.org/id/ENSBTAG00000001387" } ] } } ], "crossref": [ { "id": "A0AAA9TA72", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TA72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001387", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001387", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783802", "url": "https://www.ncbi.nlm.nih.gov/gene/783802", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CKPRTLL", "url": "https://omabrowser.org/oma/group/CKPRTLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQ74", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46947:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46947:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ74", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ74-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPY3", "url": "https://www.uniprot.org/uniprotkb/F1MPY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MPY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDCSRPAPLSMGLSRYQDFHAFDLSGATRVLEWIGDKGILVAGYDSLKKNEILHLILPLRLSVKENQGLFPERDFKVQHGGFSDRSVCDLKHVPDTRLLVTSGPPGSYLQVWQLAEDSDVIRAVSTIDVHEREEPLWPRVAIFPSVAPGVLHGTRLSSLKVVDLHSQKTMYTSGVSDDDVLSSLQVLDTDTFAFCCSSGRLGLVDTRQRWAPSENLSPGPGSTGRQWCAEAGGRGPGPSIARLGSDGQLCLLDPRDLCQPVSSVQCPVSMPSPEPELLRVTWAPGLDNCLAISGFDGTVQVYDVTSWAGVGRQVEPLFTHRGHIFLDDSGMDPAPLVTTHTWHPYKPRTVLSAASDASLHVWDWVDPCASR", "length": 371, "header": "tr|A0AAA9TA72-1|A0AAA9TA72_BOVIN Isoform 1 of WD repeat domain 73 OS=Bos taurus OX=9913 GN=WDR73 PE=4 SV=1 CANONICAL=A0AAA9TA72-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72/entry#A0A3Q1LPW0-1", "sequence": { "sequence": "MEPAEDWLVESLRLYQDFHAFDLSGATRVLEWIGDKGILVAGYDSLKKNEILHLILPLRLSVKENQGLFPERDFKVQHGGFSDRSVCDLKHVPDTRLLVTSGPPGSYLQVWQLAEDSGNSQTLPEWLHHVHSHQQCMRVPVSPCPAPTFAIICLFLLKPS", "length": 160, "header": "tr|A0A3Q1LPW0-1|A0AAA9TA72_BOVIN Computationally mapped isoform of WD repeat domain 73 OS=Bos taurus OX=9913 GN=WDR73 PE=4 SV=2 CANONICAL=A0AAA9TA72-1" }, "locus": { "chromosome": "21", "start_pos": 22315055, "end_pos": 22309472, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080113.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080113.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057009.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057009.3" } ] } }, { "isoform_ac": "A0A3Q1LQ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72/entry#A0A3Q1LQ74-1", "sequence": { "sequence": "MEPAEDWLVESLRLYQDFHAFDLSGATRVLEWIGDKGILVAGYDSLKKNEILHLILPLRLSVKENQGLFPERDFKVQHGGFSDRSVCDLKHVPDTRLLVTSGPPGSYLQVWQLAEDSDVIRAVSTIDVHEREEPLWPRVAIFPSVAPGVLHGTRLSSLKVVDLHSQKTMYTSGVSDDDVLSSLQVLDTDTFAFCCSSGRLGLVDTRQRWAPSENLSPGPGSTGRQWCAEAGGRGPGPSIARLGSDGQLCLLDPRDLCQPVSSVQCPVSMPSPEPELLRVTWAPGLDNCLAISGFDGTVQVYDVTSWAGVGRQVEPLFTHRGHIFLDDSGMDPAPLVTTHTWHPYKPRTVLSAASDASLHVWDWVDPCASR", "length": 370, "header": "tr|A0A3Q1LQ74-1|A0AAA9TA72_BOVIN Computationally mapped isoform of WD repeat domain 73 OS=Bos taurus OX=9913 GN=WDR73 PE=4 SV=1 CANONICAL=A0AAA9TA72-1" }, "locus": { "chromosome": "21", "start_pos": 22315055, "end_pos": 22303095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086269.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086269.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059110.1" } ] } }, { "isoform_ac": "A0AAA9TA72-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72/entry#A0AAA9TA72-1", "sequence": { "sequence": "MDCSRPAPLSMGLSRYQDFHAFDLSGATRVLEWIGDKGILVAGYDSLKKNEILHLILPLRLSVKENQGLFPERDFKVQHGGFSDRSVCDLKHVPDTRLLVTSGPPGSYLQVWQLAEDSDVIRAVSTIDVHEREEPLWPRVAIFPSVAPGVLHGTRLSSLKVVDLHSQKTMYTSGVSDDDVLSSLQVLDTDTFAFCCSSGRLGLVDTRQRWAPSENLSPGPGSTGRQWCAEAGGRGPGPSIARLGSDGQLCLLDPRDLCQPVSSVQCPVSMPSPEPELLRVTWAPGLDNCLAISGFDGTVQVYDVTSWAGVGRQVEPLFTHRGHIFLDDSGMDPAPLVTTHTWHPYKPRTVLSAASDASLHVWDWVDPCASR", "length": 371, "header": "tr|A0AAA9TA72-1|A0AAA9TA72_BOVIN Isoform 1 of WD repeat domain 73 OS=Bos taurus OX=9913 GN=WDR73 PE=4 SV=1 CANONICAL=A0AAA9TA72-1" }, "locus": { "chromosome": "21", "start_pos": 22314738, "end_pos": 22303095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093519.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093519.1" } ] } }, { "isoform_ac": "F1MPY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72/entry#F1MPY3-1", "sequence": { "sequence": "MAEIVPTQGRYQDFHAFDLSGATRVLEWIGDKGILVAGYDSLKKNEILHLILPLRLSVKENQGLFPERDFKVQHGGFSDRSVCDLKHVPDTRLLVTSGPPGSYLQVWQLAEDSDVIRAVSTIDVHEREEPLWPRVAIFPSVAPGVLHGTRLSSLKVVDLHSQKTMYTSGVSDDDVLSSLQVLDTDTFAFCCSSGRLGLVDTRQRWAPSENLSPGPGSTGRQWCAEAGGRGPGPSIARLGSDGQLCLLDPRDLCQPVSSVQCPVSMPSPEPELLRVTWAPGLDNCLAISGFDGTVQVYDVTSWAGVGRQVEPLFTHRGHIFLDDSGMDPAPLVTTHTWHPYKPRTVLSAASDASLHVWDWVDPCASR", "length": 366, "header": "tr|F1MPY3-1|A0AAA9TA72_BOVIN Computationally mapped isoform of WD repeat domain 73 OS=Bos taurus OX=9913 GN=WDR73 PE=4 SV=3 CANONICAL=A0AAA9TA72-1" }, "locus": { "chromosome": "21", "start_pos": 22316283, "end_pos": 22303095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001824.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001824.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001824.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001824.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A061IF21-1", "protein_name": "WD repeat-containing protein 73 isoform X1", "gene_name": "Wdr73", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELAEDWLVESLRLYQDFHAFDLSGATRVLEWIGEKGVFVAGYESSKKNEILHLILPLRLSVKENQGLFPERDFKVRHGGFSDRSVFDLKHVPDTRLLVTTGLPGCYLQVWQIGEDNDVIEAVSTIDVQDREKSLWPRVSVFSTAAPGILHGTRLSGLKTVDIESQKITYSSGTSDSESLSSLQVLDSDTFAFCGTSGRLGLVDTRQKWAPLEAFSPSPDSSGQRWCADVRNRGQGPGPCVASLGSDGQLCLLDPRNLCHPVSSAQCPVSKSSPDPELLRVSWAPGLDNCLAISGFDGTVQIYDVTSWDGKKSQVESLFTHKGHILLDGNEIDATPLVTTHTWHPCKPRTLLSAASDASLHVWDWVDLQASC", "length": 372 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A480K409-1", "protein_name": "WD repeat domain 73", "gene_name": "WDR73", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPAEDWLVESLRLYQDFHEFDLSGATRVLEWIGDKGILVAGYESLKKNEILHLILPLRLSVKENQGLFPERDFKVRHGGFSDRSVFDLKHVPDTRLLVTSGLPGCYLQVWQVAEDSDVIKAVSTIDAHEKEGHPWPRLAIFSSPAPGVLHGARLSSLKVVDLESHKSTYTSGISEDELLSSLQVLDANTFAFCCTSGRLGLVDTRQKWAPSENLRPSPGSAGGRWYAEVGGRGPGPRIASLGSDGQLCLLDLRDLSQPVSSVQCPVSTPSPDPELLRVTWAPGLDNCLAISGFDGTVQVYDVTSWNGVGGQVEPLFTHRGHIFLDDSGVDTAPLVTTHTWHPCKPRTLLSAASDASLHVWDWVDLRASH", "length": 370 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0X3H4-1", "protein_name": "WD repeat domain 73", "gene_name": "WDR73", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAAGERGEEEEEEEEEEEWLLQSLHLYEALHAFELQAPTRVIEWALGKRVCVAGYGCAGRNEILQLLPPAALEAKESRGLCPERDFKVECGGFSNRPVYNLKHVPDTSLLVTSGPPDSSLQLWQMSAEDSDVIKSVSAISTENSTGEGWAKIATISMRAPWVLHGSRLSSTQITEVESRKKVYVAASSSGEEQLSSLAFVDANTSLLCCTAGQLCVADIRQHSPLQAAPIPSAQRGQCWCMAVGRRALCSELSSQPIACLSSAGQLVLMDVRKASQCLASAKCRVPSSSCSAEFLSVSWAPALEGCLAVSAIPQSLSCTKKHVSAAWPCSLFPTSCPGHSASARIPREHPRAPGKVSTEGCNEETFGAAASIWGGFPLQINVWGRGATRRAGEQSNANAAPIKWSLGRKGGWGGGVKRSIGTLWVRLCVCVFVSEVNKLE", "length": 441 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LB16-1", "protein_name": "WD repeat domain 73", "gene_name": "Wdr73", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "YTSPATKRGGFLPRAEPLERPIQLPCPDTRLLREWGSYCFVSSGVFVAGYESLKKNEILHLILPLRLSVKENQGLYPERDFKVRHGGFSDRAVFDLKHVPDTRLLVTSGLPGCYIQVWQIREDNDVIEAVSTIDVQDKEESLWPRVSIFCSAAPGILHGARLSGLRTVDVESRKITYSSDTTDSESLSSLQVLDADTFAFCGTSGRLGLVDTRQKWAPLETVSPRAGSSGERWCAEVRSKGQGPGPCIASLGSDGQLCLLDPRNLRDPVSSAQCPVFKSSPDPELLRVTWAPGLDNCLAISGFDGTVQIYDVTSWDGKKTQVEALFIHKGHIFLDGNEVESAPLVTTHTWHPSKPRTLLSAASDAALHVWDWVDLQAS", "length": 378 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P4I2-1", "protein_name": "Integrator complex assembly factor WDR73", "gene_name": "WDR73", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPGDDWLVESLRLYQDFYAFDLSGATRVLEWIDDKGVFVAGYESLKKNEILHLKLPLRLSVKENKGLFPERDFKVRHGGFSDRSIFDLKHVPHTRLLVTSGLPGCYLQVWQVAEDSDVIKAVSTIAVHEKEESLWPRVAVFSTLAPGVLHGARLRSLQVVDLESRKTTYTSDVSDSEELSSLQVLDADTFAFCCASGRLGLVDTRQKWAPLENRSPGPGSGGERWCAEVGSWGQGPGPSIASLGSDGRLCLLDPRDLCHPVSSVQCPVSVPSPDPELLRVTWAPGLKNCLAISGFDGTVQVYDATSWDGTRSQDGTRSQVEPLFTHRGHIFLDGNGMDPAPLVTTHTWHPCRPRTLLSATNDASLHVWDWVDLCAPR", "length": 378 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CWR1-1", "protein_name": "Integrator complex assembly factor WDR73", "gene_name": "Wdr73", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELAEDWLVESLRLYQDFHAFDLSGATRVLEWIGEKGVFVAGYESLKKNEILHLILPLRLSVQENQGLHPERDFKVRHGGFSDRSVFDLKHVPDTRLLVTSGLPGCYIQMWQVREDNDVIEAVSTIDVQDKEESLWPRVSVFCSKAPGILHGARLSGLRTVDVESQKITYSSGTADSESLSCLQVLDANTFAFCGNSGRLGLVDTRQKWAALETVSPGSGCSGERWCAEVRNKGQGPGPCIASLGSDGQLCLLDSRNLCHPVSSAQCPVFKPSPDPELLRVTWAPGLDNCLAISGFDGTVQIYDVTSWDGKKTQAEPLFTHKGHIFLDGNDVDSAPLVTTHTWHPRKPRTLLSAASDSSLHVWDWVDLQAS", "length": 371 }, "evidence": [ { "id": "A0AAA9TA72", "url": "https://omabrowser.org/oma/group/A0AAA9TA72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA72", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TC65-1", "uniprot_ac": "A0AAA9TC65", "uniprot_id": "A0AAA9TC65_BOVIN", "mass": { "chemical_mass": 87530.0, "monoisotopic_mass": 87530.0 }, "refseq": {}, "gene_names": [ { "name": "BEGAIN", "type": "recommended", "evidence": [ { "id": "A0AAA9TC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65" } ] } ], "protein_names": [ { "name": "Brain enriched guanylate kinase associated", "type": "synonym", "evidence": [ { "id": "A0AAA9TC65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BEGAIN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65", "locus": { "chromosome": "21", "start_pos": 65422433, "end_pos": 65468914, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017716", "url": "https://www.ensembl.org/id/ENSBTAG00000017716" } ] } } ], "crossref": [ { "id": "A0AAA9TC65", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TC65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017716", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017716", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527886", "url": "https://www.ncbi.nlm.nih.gov/gene/527886", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR043441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527886", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527886", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDICCSD", "url": "https://omabrowser.org/oma/group/EDICCSD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZG7", "url": "https://www.orthodb.org/?gene=A0A3Q1LZG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BD66", "url": "https://www.orthodb.org/?gene=E1BD66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28664", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28664", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28664:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28664:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27583", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27583", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5E9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5E9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5E9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5E9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN53", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NN53-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NN53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD66", "url": "https://www.uniprot.org/uniprotkb/E1BD66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BD66-1", "url": "https://www.uniprot.org/uniprotkb/E1BD66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSGAGSQAQGPDPGSPRQDGPSSLTEPRAEAPRKEACREDLRGCKPSPTSGQNPKGPPSYPGWAASQPGQEATKASPGPLSAAELPGTGSRPAPGPLAWLGRRREARLPFSKFLDEVAVRVLDPGMLEAFRGPRGRSPEPSPGEQDPGPAQEALAGATAPEKILALSPQLSSEIALEAASGAGPGQAMETTGLRVGSSKRGGRAASPRSPPGRASAADMEKLSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 821, "header": "tr|A0AAA9TC65-1|A0AAA9TC65_BOVIN Isoform 1 of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=1 CANONICAL=A0AAA9TC65-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#A0A3Q1LZG7-1", "sequence": { "sequence": "MWTGGRRPGRLRRAASAADMEKLRLRSAWVPSCLGQSRNLQGRRARSSPSLWDSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 651, "header": "tr|A0A3Q1LZG7-1|A0AAA9TC65_BOVIN Computationally mapped isoform of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=2 CANONICAL=A0AAA9TC65-1" }, "locus": { "chromosome": "21", "start_pos": 65468743, "end_pos": 65423427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070975.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070975.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066244.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066244.2" } ] } }, { "isoform_ac": "A0A3Q1M5E9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#A0A3Q1M5E9-1", "sequence": { "sequence": "MPRPCLLSACCMLGSSVLSALMGTRERWAWVHRGRRGGVGQSASSLSWGRRVYRGVWARGLRQLLERRGLCLAANPEASGILSSEIPSRTPAPPQSAMQKGNRTPRPAPPAPKSSSQASAADMEKLRLRSAWVPSCLGQSRNLQGRRARSSPSLWDSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 754, "header": "tr|A0A3Q1M5E9-1|A0AAA9TC65_BOVIN Computationally mapped isoform of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=1 CANONICAL=A0AAA9TC65-1" }, "locus": { "chromosome": "21", "start_pos": 65451653, "end_pos": 65423427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065514.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065514.2" } ] } }, { "isoform_ac": "A0A3Q1NN53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#A0A3Q1NN53-1", "sequence": { "sequence": "MEKLRLRSAWVPSCLGQSRNLQGRRARSSPSLWDSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 632, "header": "tr|A0A3Q1NN53-1|A0AAA9TC65_BOVIN Computationally mapped isoform of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=1 CANONICAL=A0AAA9TC65-1" }, "locus": { "chromosome": "21", "start_pos": 65450042, "end_pos": 65423427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077500.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077500.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074120.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074120.2" } ] } }, { "isoform_ac": "A0AAA9TC65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#A0AAA9TC65-1", "sequence": { "sequence": "MLSGAGSQAQGPDPGSPRQDGPSSLTEPRAEAPRKEACREDLRGCKPSPTSGQNPKGPPSYPGWAASQPGQEATKASPGPLSAAELPGTGSRPAPGPLAWLGRRREARLPFSKFLDEVAVRVLDPGMLEAFRGPRGRSPEPSPGEQDPGPAQEALAGATAPEKILALSPQLSSEIALEAASGAGPGQAMETTGLRVGSSKRGGRAASPRSPPGRASAADMEKLSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 821, "header": "tr|A0AAA9TC65-1|A0AAA9TC65_BOVIN Isoform 1 of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=1 CANONICAL=A0AAA9TC65-1" }, "locus": { "chromosome": "21", "start_pos": 65459850, "end_pos": 65423427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114495.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114495.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095649.1" } ] } }, { "isoform_ac": "E1BD66-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC65/entry#E1BD66-1", "sequence": { "sequence": "MLSGAGSQAQGPDPGSPRQDGPSSLTEPRAEAPRKEACREDLRGCKPSPTSGQNPKGPPSYPGWAASQPGQEATKASPGPLSAAELPGTGSRPAPGPLAWLGRRREARLPFSKFLDEVAVRVLDPGMLEAFRGPRGRSPEPSPGEQDPGPAQEALAGATAPEKILALSPQLSSEIALEAASGAGPGQAMETTGLRVGSSKRGGRAASPRSPPGRASAADMEKLRLRSAWVPSCLGQSRNLQGRRARSSPSLWDSSLQEQKGELRKRLSYTTHRLEKLENEFDSTRHFLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLFRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCSLAAQLLQCSQTYGRGRKMAELPAEFQERMNLHAEKPGCSLPAPLCRPAYADSVPPCVLAKVLEKPDPGSLSSHLSEASAQDLGFPEGLEKPGSRPPYKGDIYCSDTALYCPEERHRDRRPSVEGPGSDVGFLQAQNSTDSTAEEEEEEEDTEAGAAAYPASYRHEAFGGYAASLPTSSSYSSFSAASEEKEHAQASTLTASQQAIYLNSRDELFGRKPPAAYGSSPRYAAAAAAVAAPLEAAVAPGFPRTVSPFPAEPFRFPLSPGPQPALMPPNLWNLRAKPGSARLVAGAGRGQWRPLSVDDIGAYPFPAAAAAPAPSLASPGGFNDRYYGARGSPGENAEGRASPLYASYKADSFSEGDDLSQGHLVEPRYLRAAGDLSLSPGRSADPLPSYAASEGDRERLGVQLLGASGSPEPELSLRSSRDSLEPSSMEASPEMHPGARLSPQPAFPRAGSSGLSRKDSLTKAQLYGTLLN", "length": 851, "header": "tr|E1BD66-1|A0AAA9TC65_BOVIN Computationally mapped isoform of Brain enriched guanylate kinase associated OS=Bos taurus OX=9913 GN=BEGAIN PE=4 SV=3 CANONICAL=A0AAA9TC65-1" }, "locus": { "chromosome": "21", "start_pos": 65459850, "end_pos": 65423427, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023562.7", "url": "https://www.ensembl.org/id/ENSBTAT00000023562.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023562.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023562.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:527886", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527886", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O88881-1", "protein_name": "Brain-enriched guanylate kinase-associated protein", "gene_name": "Begain", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWTGGRRPGRLRRAASAADMEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSPLCHPSYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLAYRDGVENPGPRPPYKGDIYCSDTALYCPDERDHDRRPSVDTPVTDVGFLRAQNSTDSLAEEEEAEAAAFPEAYRREAFQGYAASLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSREELFSRKPPSATYGSSPRYAKAAATLGSPLEAQVAPGFARTVSPYPAEPYRYPASQQALMPPNLWSLRAKPSGNRLAAREDIRGQWRPLSVEDVGAYSYQAGAAGRAASPCNFSERFYGGGGGGGSPGKNAEGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADPLPGYATSDGDGDRLGVQLCGPGSSPEPEHGSRDSLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN", "length": 611 }, "evidence": [ { "id": "A0AAA9TC65", "url": "https://omabrowser.org/oma/group/A0AAA9TC65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q68EF6-1", "protein_name": "Brain-enriched guanylate kinase-associated protein", "gene_name": "Begain", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELDKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRAMSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQQRVSLHMEKHGCSLPSALCHPAYADSVPTCVIAKVLEKPDPGSLSSRMSDASARDLGYRDGVEKSGPRPPYKGDIYCSDPALYCPDEREHARRPSVDTPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPEAYRREAYQGYAASLPTSSSYSSFSATSEEKEHAQAGTLTASQQAIYLSSRDEFFNRKPSATYGSGPRFAKAASTLGSPLEAQVAPGFARTVSPYPAEPYRYPASPGPQQALMPPNLWSLRAKPSGNRLAGEDIRGQWRPVSVEDVGAYSYQAGAAAGRAASPCNYSERYYGGGGGGGAAGGGSPGDKAEGRASPLYATYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPSRSADALAGYAASDGDGDRLRVQLCGAGSSPEPEHGSRESLEPSSMEASPEMHPPTRLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN", "length": 600 }, "evidence": [ { "id": "A0AAA9TC65", "url": "https://omabrowser.org/oma/group/A0AAA9TC65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BUH8-1", "protein_name": "Brain-enriched guanylate kinase-associated protein", "gene_name": "BEGAIN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELEKVTEKLRRIQSNYMALQRINQELEDKLYRMGQHYEEEKRALSHEIVALNSHLLEAKVTIDKLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQERVSLHMEKHGCSLPSPLCHPAYADSVPTCVIAKVLEKPDPASLSSRLSDASARDLAFCDGVEKPGPRPPYKGDIYCSDTALYCPEERRRDRRPSVDAPVTDVGFLRAQNSTDSAAEEEEEAEAAAFPAGFQHEAFPSYAGSLPTSSSYSSFSATSEEKEHAQASTLTASQQAIYLNSRDELFDRKPPATTYEGSPRFAKATAAVAAPLEAEVAPGFGRTMSPYPAETFRFPASPGPQQALMPPNLWSLRAKPGTARLPGEDMRGQWRPLSVEDIGAYSYPVSAAGRASPCSFSERYYGGAGGSPGKKADGRASPLYASYKADSFSEGDDLSQGHLAEPCFLRAGGDLSLSPGRSADPLPGYAPSEGGDGDRLGVQLCGTASSPEPEQGSRDSLEPSSMEASPEMHPAARLSPQQAFPRTGGSGLSRKDSLTKAQLYGTLLN", "length": 593 }, "evidence": [ { "id": "A0AAA9TC65", "url": "https://omabrowser.org/oma/group/A0AAA9TC65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "evoked excitatory postsynaptic potential", "id": "GO:0098817", "url": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TBJ6-1", "uniprot_ac": "A0AAA9TBJ6", "uniprot_id": "A0AAA9TBJ6_BOVIN", "mass": { "chemical_mass": 14855.0, "monoisotopic_mass": 14855.0 }, "refseq": {}, "gene_names": [ { "name": "RIPPLY2", "type": "recommended", "evidence": [ { "id": "A0AAA9TBJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBJ6" } ] } ], "protein_names": [ { "name": "Ripply transcriptional repressor 2", "type": "synonym", "evidence": [ { "id": "A0AAA9TBJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBJ6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": 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"https://www.uniprot.org/uniprotkb/A0AAA9TA10" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily domain containing 4B", "type": "synonym", "evidence": [ { "id": "A0AAA9TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFSD4B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10", "locus": { "chromosome": "9", "start_pos": 39140790, "end_pos": 39148316, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009243", "url": "https://www.ensembl.org/id/ENSBTAG00000009243" } ] } } ], "crossref": [ { "id": "A0AAA9TA10", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TA10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009243", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009243", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPWCKKA", "url": "https://omabrowser.org/oma/group/IPWCKKA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23121:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23121:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4I2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4I2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPC8", "url": "https://www.uniprot.org/uniprotkb/F1MPC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MPC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLNKILFLNLLHAGGMSVAILGPTFQDLATNVNRNISRLSLIFVGRAFGYLGGSVIGGVLFDSMNHFLLLGVSMFATTVGLYLVPFCKTAVLLIVMMSTFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGTTVSAENRTEADFNQSAFNQSSEADSESLFGIPDDMNLLWAYAVIGTYIFVVALFFFALFLKKSSKQEKARVSAQRFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKEREAAGLNSIFWGTFAACRGMAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFNKSPVCLWIATSVYGASMATTFPSGVSWIEQYTTIHGKAAAFFVVGAALGEMAIPAVIGILQGKYPDLPVVLYTSLGSSIATAILFPVLYKLATLPLDRQRKEHRKSEDQKALLSSSGLNDYEEENEEDDAEKWNEMDFEVIEMNDTMRNSVIETSRNILMEPTAEVPNHSYSNVLMFESSPVNTGNSSVNYLARNQDKRD", "length": 523, "header": "tr|A0AAA9TA10-1|A0AAA9TA10_BOVIN Isoform 1 of Major facilitator superfamily domain containing 4B OS=Bos taurus OX=9913 GN=MFSD4B PE=4 SV=1 CANONICAL=A0AAA9TA10-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4I2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10/entry#A0AAA9S4I2-1", "sequence": { "sequence": "MSVAILGPTFQDLATNVNRNISRLSLIFVGRAFGYLGGSVIGGVLFDSMNHFLLLGVSMFATTVGLYLVPFCKTAVLLIVMMSTFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGTTVSAENRTEADFNQSAFNQSSEADSESLFGIPDDMNLLWAYAVIGTYIFVVALFFFALFLKKSSKQEKARVSAQRFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKEREAAGLNSIFWGTFAACRGMAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFNKSPVCLWIATSVYGASMATTFPSGVSWIEQYTTIHGKAAAFFVVGAALGEMAIPAVIGILQGKYPDLPVVLYTSLGSSIATAILFPVLYKLATLPLDRQRKEHRKSEDQKALLSSSGLNDYEEENEEDDAEKWNEMDFEVIEMNDTMRNSVIETSRNILMEPTAEVPNHSYSNVLMFESSPVNTGNSSVNYLARNQDKRD", "length": 507, "header": "tr|A0AAA9S4I2-1|A0AAA9TA10_BOVIN Computationally mapped isoform of Major facilitator superfamily domain containing 4B OS=Bos taurus OX=9913 GN=MFSD4B PE=4 SV=1 CANONICAL=A0AAA9TA10-1" }, "locus": { "chromosome": "9", "start_pos": 39146241, "end_pos": 39141794, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130164.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130164.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078164.1" } ] } }, { "isoform_ac": "A0AAA9TA10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10/entry#A0AAA9TA10-1", "sequence": { "sequence": "MSLNKILFLNLLHAGGMSVAILGPTFQDLATNVNRNISRLSLIFVGRAFGYLGGSVIGGVLFDSMNHFLLLGVSMFATTVGLYLVPFCKTAVLLIVMMSTFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGTTVSAENRTEADFNQSAFNQSSEADSESLFGIPDDMNLLWAYAVIGTYIFVVALFFFALFLKKSSKQEKARVSAQRFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKEREAAGLNSIFWGTFAACRGMAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFNKSPVCLWIATSVYGASMATTFPSGVSWIEQYTTIHGKAAAFFVVGAALGEMAIPAVIGILQGKYPDLPVVLYTSLGSSIATAILFPVLYKLATLPLDRQRKEHRKSEDQKALLSSSGLNDYEEENEEDDAEKWNEMDFEVIEMNDTMRNSVIETSRNILMEPTAEVPNHSYSNVLMFESSPVNTGNSSVNYLARNQDKRD", "length": 523, "header": "tr|A0AAA9TA10-1|A0AAA9TA10_BOVIN Isoform 1 of Major facilitator superfamily domain containing 4B OS=Bos taurus OX=9913 GN=MFSD4B PE=4 SV=1 CANONICAL=A0AAA9TA10-1" }, "locus": { "chromosome": "9", "start_pos": 39146916, "end_pos": 39141794, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104282.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104282.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092773.1" } ] } }, { "isoform_ac": "F1MPC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10/entry#F1MPC8-1", "sequence": { "sequence": "MELELEPCGAGAPAAGQRLLQAEAPAENEPEAVVGSRRSGRADSMLRWFITVLLCAAFLGLGMSVAILGPTFQDLATNVNRNISRLSLIFVGRAFGYLGGSVIGGVLFDSMNHFLLLGVSMFATTVGLYLVPFCKTAVLLIVMMSTFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGTTVSAENRTEADFNQSAFNQSSEADSESLFGIPDDMNLLWAYAVIGTYIFVVALFFFALFLKKSSKQEKARVSAQRFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKEREAAGLNSIFWGTFAACRGMAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFNKSPVCLWIATSVYGASMATTFPSGVSWIEQYTTIHGKAAAFFVVGAALGEMAIPAVIGILQGKYPDLPVVLYTSLGSSIATAILFPVLYKLATLPLDRQRKEHRKSEDQKALLSSSGLNDYEEENEEDDAEKWNEMDFEVIEMNDTMRNSVIETSRNILMEPTAEVPNHSYSNVLMFESSPVNTGNSSVNYLARNQDKRD", "length": 569, "header": "tr|F1MPC8-1|A0AAA9TA10_BOVIN Computationally mapped isoform of Major facilitator superfamily domain containing 4B OS=Bos taurus OX=9913 GN=MFSD4B PE=4 SV=2 CANONICAL=A0AAA9TA10-1" }, "locus": { "chromosome": "9", "start_pos": 39148117, "end_pos": 39141794, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037995.3", "url": "https://www.ensembl.org/id/ENSBTAT00000037995.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037814.2", "url": "https://www.ensembl.org/id/ENSBTAP00000037814.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-189200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "resource": "Reactome", "description": "Cellular hexose transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MLY3-1", "protein_name": "Sodium-dependent glucose transporter 1", "gene_name": "Mfsd4b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIGGVLFGCINHFLLLGVSLSATTVGLYLTPFCKTAVLLVIMMSVFGISMGLLDTGGNVLILDLWGDEGAPHMQALHFSFALGAFLAPLLAKLAWGTSASTQNHTEPDFDLLMLNGSSEATSDSLFAVPEDMNLLWAYASIGTYVLVVSVFLFGLFCKKSSRQEKATVSAQEARRAKYHWALLCLLFIFFFFYVGAEVTYGSYVFSFATTHVGMKESEAAGLNSIFWGTFAACRGLAIFFATFLKPGTMIVLCNIGSLTSSLFLVLFDKSPLCLWIATSVYGASMAATFPSGISWIEQYTSISGKSAAFFVIGAALGEMAIPAIIGILQGHYPDLPVVLYTGLGSATFTAVLFPVMYKLATLPLGHQPKGRKSEDQRALLSSSELNDCEEESEEEDAEKWNEMDFEVVEMSDPMQESARDTTGEVLREPTPEASDHFLSKAYFSVSSSDPLVNHQDKRD", "length": 459 }, "evidence": [ { "id": "A0AAA9TA10", "url": "https://omabrowser.org/oma/group/A0AAA9TA10/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YKY3-1", "protein_name": "Major facilitator superfamily domain containing 4B", "gene_name": "MFSD4B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGAERKKHVRFAGSAQVAAGPGPGPGPGPGPRLPAAPHAEVAVVGGRRCGEGAALRWCVSAALCAAFLGLGTSIAVLGPTFQNLADNVHKNVTDIYYIFVGRSLGYLGGSVLGGILFDHVNAHLLLAFSMLGTTAGLFAIPWCKRSLLLTALMSLIGAAMGVLDTGGNVLALNTWGTEAGPHLQALHFSFAMGAFVAPILAKMAMGNSEPRDLQAGENASQSVLSPVPTASATLALKHHLGVDFLWSYIVIGTYLLFVSFFFFILYSKSSSVRDKSKASAQKCKVAKYHHVLIILLFLFFLCYVGAEVTYGSYIFTYAKVFAEMKESEAAALNSVFWGAFAVCRAVSVFCAACLYPGTMIVLSLIGSAVSSSSLAFFAHYPISLWAGTAVYGASMATIFPSGISWIEQYTVIQGKSASLFVVGAALGEMCIPAVVGYLQGRFHHVPVVMYTALGTSAMTAVLFPVMYKLATASGESSREMSESEDRKALLSSSGLNEDEEDEEDAGEWNEADFEVIEMNDTLRNSVVETSLKAAGDSSSEASLQPHPADAGGDFPVAAGSSPGRKSMNVDREKND", "length": 576 }, "evidence": [ { "id": "A0AAA9TA10", "url": "https://omabrowser.org/oma/group/A0AAA9TA10/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LTM4-1", "protein_name": "Major facilitator superfamily domain containing 4B1", "gene_name": "Mfsd4b4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGARSSAGGAATLELELEFGGAGGQRLLQAGPGAENESEAVASVRSGSAQSVLRWFTTVVLCAAFLGLGLSVAILGPTFPDLARNVNRNISSLSLIFVGRASGYLCGSMIGGVLFDCINHFLLLGMSLSATTVGLYLMPFCKIAALLIVLMSVFGVSMGILDTGGNVLILDLWGDKGAPHMQALHFSFALGAFLAPLLAKLAWGTTASAQNHTESDFISLMLNRTSEAATDSVFAVPDDMNLLWTYASIGTYVLVVSVFLFALFCKKRSRQKKSSASAQGTRRAKYHRALLCLLFLFFFFYVGAEVTYGSYVFSFATTHVGMEESEAAGLNSIFWGTFAACRGLAIFFATCLQPGTMIVVSNIGSLASSFFLVLFDKSPLCLWIASSVYGASMAATFPSGISWIEQYTTLTGKSASFFVIGAALGEMAIPAVIGILQGHYPDLPVVLYTGLGSAIFTAVLFPVMYKLATLPLERQRKGRRKSEDQKALLSSSELHDCEEEIEEEEDAEKWNEMDFEVVEMNDPVQGSVRGTSGDVMGPTAEGSDQFLPDALSFEPLSASSSNSLANH", "length": 568 }, "evidence": [ { "id": "A0AAA9TA10", "url": "https://omabrowser.org/oma/group/A0AAA9TA10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "J3QNS5-1", "protein_name": "Major facilitator superfamily domain containing 4B4", "gene_name": "Mfsd4b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDFNAEGLSVAILGPTFPDLAKNVNRNISSLSLIFVGRASGYLCGSMIGGVLFGCINHFLLLGVSLSATTVGLYLMPFCKTAALLIVMMSVFGVSMGILDTGGNVLILDLWGDKGAPHMQALHFSFALGAFLAPLLAKLAWGTTTSAQNYTEPQSDRLALNQSFEATSDSVFAVPDDMNLLWTYASIGTYVLVVSVFLFGLFCKKHSRQKKPRASAEGARRAKYHRALLCLLFLFFFFYVGAEVTYGSFVFSFAITHVGMEESEAAGLNSIFWGTFAACRGLAIFFATFLQPGTMIVLCNIGSLVSCFFLVLFDKSPLCLWIATSVYGASMAATFPSGISWIEQYTTLTGKSAAFFVIGAALGEMAIPAVIGILQGQYPDLPVVLYTCLGSAIFTAVLFPVMYKLATLPLECQHKGTRKREDQKALLSSSELHDCEEENEEDDAEKWNEMDFEVVEMSDPVQESARETCREEGSGQVLLDGLIAEPFSANSSNSLGNHQDKRD", "length": 503 }, "evidence": [ { "id": "A0AAA9TA10", "url": "https://omabrowser.org/oma/group/A0AAA9TA10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5TF39-1", "protein_name": "Solute carrier family 60 member 2", "gene_name": "SLC60A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLCASFLGLGLSVAIVGPTFQDLATNVNRNISSLSFIFVGRALGYLSGSVIGGFLVDVMNYFLLLGISMSATTVGLYLVPFCKTAILLTVMMSIFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGPTASAENHTESDFHPALNQSSDADSEALFGVPNDKNLLWAYAVIGTYMFLVSVIFFCLFLKNSSKQEKARASAETFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKESEAAGLNSIFWGTFAACRGLAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFDKNPICLWIATSVYGASMATTFPSGVSWIEQYTTIHGKSAAFFVIGASLGEMAIPAVIGILQGKYPDLPVVLYTSLGASIATGILFPVLYKLATSPLDRQRKEDRKSEDQKALLSSSGLNEYEEENEEEDAEKWNEMDFEMIETNDTMRHSIIETSRSSLTEPTAEVYNQYPSNALVFESSPFNTGSAHVKHLPETRTKGTNV", "length": 518 }, "evidence": [ { "id": "A0AAA9TA10", "url": "https://omabrowser.org/oma/group/A0AAA9TA10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 323, "end_pos": 325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 467, "end_pos": 469, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 170, "end_pos": 172 }, { "start_pos": 323, "end_pos": 325 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 467, "end_pos": 469 }, { "start_pos": 491, "end_pos": 493 }, { "start_pos": 509, "end_pos": 511 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCU1-1", "uniprot_ac": "A0AAA9TCU1", "uniprot_id": "A0AAA9TCU1_BOVIN", "mass": { "chemical_mass": 46420.0, "monoisotopic_mass": 46420.0 }, "refseq": { "ac": "XP_002690509", "name": "integral membrane protein GPR137C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690509" }, "gene_names": [ { "name": "GPR137C", "type": "recommended", "evidence": [ { "id": "A0AAA9TCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1" } ] }, { "name": "GPR137C", "type": "synonym", "evidence": [ { "id": "XP_002690509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690509" } ] } ], "protein_names": [ { "name": "G protein-coupled receptor 137C", "type": "synonym", "evidence": [ { "id": "A0AAA9TCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1/entry#names_and_taxonomy" } ] }, { "name": "integral membrane protein GPR137C", "type": "synonym", "evidence": [ { "id": "XP_002690509", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690509" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR137C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1", "locus": { "chromosome": "10", "start_pos": 11554685, "end_pos": 11615746, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000821", "url": "https://www.ensembl.org/id/ENSBTAG00000000821" } ] } } ], "crossref": [ { "id": "A0AAA9TCU1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCU1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000821", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000821", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21475", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21475", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616594", "url": "https://www.ncbi.nlm.nih.gov/gene/616594", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616594", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616594", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCMCKLS", "url": "https://omabrowser.org/oma/group/CCMCKLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MW16", "url": "https://www.orthodb.org/?gene=F1MW16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15146", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15146", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15146:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15146:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27607", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27607", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690509", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690509", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TCU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW16", "url": "https://www.uniprot.org/uniprotkb/F1MW16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW16-1", "url": "https://www.uniprot.org/uniprotkb/F1MW16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVSVPGPAAGREPSTPGGGGGDAVAAASGAAVPGSVQLALSILHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDKHKILLHLGFILASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVSYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKAHVKDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLSNSQGLGWYGTMTGCGSSSYTVSPHLNGPLTDTAPLLFTCSNLDMNSHHSLYVTPQN", "length": 421, "header": "tr|A0AAA9TCU1-1|A0AAA9TCU1_BOVIN Isoform 1 of G protein-coupled receptor 137C OS=Bos taurus OX=9913 GN=GPR137C PE=4 SV=1 CANONICAL=A0AAA9TCU1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1/entry#A0AAA9TCU1-1", "sequence": { "sequence": "MRVSVPGPAAGREPSTPGGGGGDAVAAASGAAVPGSVQLALSILHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDKHKILLHLGFILASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVSYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKAHVKDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLSNSQGLGWYGTMTGCGSSSYTVSPHLNGPLTDTAPLLFTCSNLDMNSHHSLYVTPQN", "length": 421, "header": "tr|A0AAA9TCU1-1|A0AAA9TCU1_BOVIN Isoform 1 of G protein-coupled receptor 137C OS=Bos taurus OX=9913 GN=GPR137C PE=4 SV=1 CANONICAL=A0AAA9TCU1-1" }, "locus": { "chromosome": "10", "start_pos": 11615643, "end_pos": 11555689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132889.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132889.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094676.1" } ] } }, { "isoform_ac": "F1MW16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1/entry#F1MW16-1", "sequence": { "sequence": "MRVSVPGPAAGREPSTPGGGGGDAVAAASGAAVPGSVQLALSILHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEYLRTCLLQDFMKEVICKVRCATELDKHKILLHLGFILASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVSYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKAHVKDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLSNSQGLGWYGTMTGCGSSSYTVSPHLNGPLTDTAPLLFTCSNLDMNSHHSLYVTPQN", "length": 434, "header": "tr|F1MW16-1|A0AAA9TCU1_BOVIN Computationally mapped isoform of G protein-coupled receptor 137C OS=Bos taurus OX=9913 GN=GPR137C PE=4 SV=3 CANONICAL=A0AAA9TCU1-1" }, "locus": { "chromosome": "10", "start_pos": 11615643, "end_pos": 11555689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001087.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001087.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001087.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001087.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616594", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616594", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZFP1-1", "protein_name": "G protein-coupled receptor 137C", "gene_name": "Gpr137c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRESVPGPAAAAVPTAGREPSTPGGGAVAASGAAVPGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSLSGSLPLLRPPSRLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDKHKILLHLGFILASLLFLAVNLTCAMLVHGDVPENQLKWTVFVRALVNDSLFILCAISLVSYICKITKMSSANVYLESKGMSLCQTVIVGSVVFLLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKARGEDGNGVDYMVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMISSHSYSSRAFFFDNPRRYDSDDDLPRLGSSREGSLSNPQTLGWYGTMAGCGGSTYTVTPPLNGPVTDTAPLLFTCSNLDLRNHHSLYVTPQN", "length": 423 }, "evidence": [ { "id": "A0AAA9TCU1", "url": "https://omabrowser.org/oma/group/A0AAA9TCU1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q343-1", "protein_name": "G protein-coupled receptor 137C", "gene_name": "Gpr137c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRVSVSGPAAAAVPTAGREPSTSGGGAVAASGAAVPGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSLSGSLPLLRPPSRLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDKHKILLHLGFILASLLFLAVNLTCAMLVHGDVPENQLKWTVFIRALINDSLFILCAISLVSYICKITKMSSANVYLESKGMSLCQTVIVGSVVILLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKAQGEDGNGGDYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMISSHSYSSRAFFFDNPRRYDSDDDLPRLGNSREGSLSNSQTLGWYGTMTGCGGGTYTVTPPLNGPVTDTAPLLFTCSNLDIRNHHSLYVTPQN", "length": 423 }, "evidence": [ { "id": "A0AAA9TCU1", "url": "https://omabrowser.org/oma/group/A0AAA9TCU1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1NU49-1", "protein_name": "G protein-coupled receptor 137C", "gene_name": "GPR137C", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSALAAGAALAEGPAVPYAVELGLTVLHTALYAALFLFAYLQLWLLLYYRERRLSYHTLCLFLCLLWAALRTTLFSFYLQNSLQALRLQQPFAHWLLYCLPGCLLFASLCLLNLYFAEVIFKVKCAADFNKYKVLLYLGSILTSLLFLVVNLTCAMLIHSEVPENQLRRTVLARALVNDSLFILCAISLACCMCKLGKMSSANVYLESKGTSVCQAILVGSVVALLYSSRACYNLVAVAISPDSVPGPFNYGWDNLSDKVHVEVSSEEYVVFGVVLFLWELVPTTFVVLFFRAQRLSQNLTPAGMVNSHSYSSRAYFFDNPRRYDSDDDLSRLGAREGGLATPQCSGCYGSLAGNDSYTAGPPPSGTATDSAPLLSAAGGSELSNHHSSYPAAQN", "length": 395 }, "evidence": [ { "id": "A0AAA9TCU1", "url": "https://omabrowser.org/oma/group/A0AAA9TCU1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SFE8-1", "protein_name": "G protein-coupled receptor 137C", "gene_name": "GPR137C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRVSVPGPAASREPSTPGGSGGGGGAVAAASGAAVPGSVQLALSILHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDKHKILLHLGFTLASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVSYICKVTKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVITISQDTLESPFNYGWDNLSDKAHIKDVSGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLSNSQGLGWYGTMTGCGSNSYTVSPHLNGPMTDTAPLLFTCSNLDMNNHHSLYVTPQN", "length": 423 }, "evidence": [ { "id": "A0AAA9TCU1", "url": "https://omabrowser.org/oma/group/A0AAA9TCU1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N3F9-1", "protein_name": "Integral membrane protein GPR137C", "gene_name": "GPR137C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVSVPGPAAAAAPAAGREPSTPGGGSGGGGAVAAASGAAVPGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLLWAALRTTLFSAAFSLSGSLPLLRPPAHLHFFPHWLLYCFPSCLQFSTLCLLNLYLAEVICKVRCATELDRHKILLHLGFIMASLLFLVVNLTCAMLVHGDVPENQLKWTVFVRALINDSLFILCAISLVCYICKITKMSSANVYLESKGMSLCQTVVVGSVVILLYSSRACYNLVVVTISQDTLESPFNYGWDNLSDKAHVEDISGEEYIVFGMVLFLWEHVPAWSVVLFFRAQRLNQNLAPAGMINSHSYSSRAYFFDNPRRYDSDDDLPRLGSSREGSLPNSQSLGWYGTMTGCGSSSYTVTPHLNGPMTDTAPLLFTCSNLDLNNHHSLYVTPQN", "length": 429 }, "evidence": [ { "id": "A0AAA9TCU1", "url": "https://omabrowser.org/oma/group/A0AAA9TCU1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 200, "end_pos": 202, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 200, "end_pos": 202 }, { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFGE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4", "locus": { "chromosome": "21", "start_pos": 20467443, "end_pos": 20482504, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003300", "url": "https://www.ensembl.org/id/ENSBTAG00000003300" } ] } } ], "crossref": [ { "id": "A0AAA9TCV4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003300", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003300", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NPCYHNA", "url": "https://omabrowser.org/oma/group/NPCYHNA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MXX6", "url": "https://www.orthodb.org/?gene=F1MXX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MYW7", "url": "https://www.orthodb.org/?gene=G3MYW7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00754", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00754", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RUL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S567", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S567", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S567-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S567-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXX6", "url": "https://www.uniprot.org/uniprotkb/F1MXX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXX6-1", "url": "https://www.uniprot.org/uniprotkb/F1MXX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYW7", "url": "https://www.uniprot.org/uniprotkb/G3MYW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYW7-1", "url": "https://www.uniprot.org/uniprotkb/G3MYW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCPRLLAALCGALFCSSGLFAFSGPCFPNPCHNDAECQVTDDSHRGDVFIQYICKCPLGYVGIHCETTCTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIDLGSQKRVTGIITQGARDFGHIQYVAAYRVAYGDDGVTWTEYKDPGASESKIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 388, "header": "tr|A0AAA9TCV4-1|A0AAA9TCV4_BOVIN Isoform 1 of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=1 CANONICAL=A0AAA9TCV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4/entry#A0AAA9RUL8-1", "sequence": { "sequence": "MSPPLNLPALWQKPFSLGPSRRLLQSHHLFPLTSYFFLKIGDFCDSSQCLHGGTCLLNEDRTPPFYCLCPEGFTGLLCNETEHGPCFPNPCHNDAECQVTDDSHRGDVFIQYICKCPLGYVGIHCETTCTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIDLGSQKRVTGIITQGARDFGHIQYVAAYRVAYGDDGVTWTEYKDPGASESKIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 447, "header": "tr|A0AAA9RUL8-1|A0AAA9TCV4_BOVIN Computationally mapped isoform of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=1 CANONICAL=A0AAA9TCV4-1" }, "locus": { "chromosome": "21", "start_pos": 20479913, "end_pos": 20468082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110413.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110413.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075870.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075870.1" } ] } }, { "isoform_ac": "A0AAA9S567-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4/entry#A0AAA9S567-1", "sequence": { "sequence": "MPCPRLLAALCGALFCSSGLFAFSACTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIDLGSQKRVTGIITQGARDFGHIQYVAAYRVAYGDDGVTWTEYKDPGASESKIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 344, "header": "tr|A0AAA9S567-1|A0AAA9TCV4_BOVIN Computationally mapped isoform of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=1 CANONICAL=A0AAA9TCV4-1" }, "locus": { "chromosome": "21", "start_pos": 20482449, "end_pos": 20468082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114497.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114497.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078997.1" } ] } }, { "isoform_ac": "A0AAA9TCV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4/entry#A0AAA9TCV4-1", "sequence": { "sequence": "MPCPRLLAALCGALFCSSGLFAFSGPCFPNPCHNDAECQVTDDSHRGDVFIQYICKCPLGYVGIHCETTCTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIDLGSQKRVTGIITQGARDFGHIQYVAAYRVAYGDDGVTWTEYKDPGASESKIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 388, "header": "tr|A0AAA9TCV4-1|A0AAA9TCV4_BOVIN Isoform 1 of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=1 CANONICAL=A0AAA9TCV4-1" }, "locus": { "chromosome": "21", "start_pos": 20482449, "end_pos": 20468082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126526.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126526.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094573.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094573.1" } ] } }, { "isoform_ac": "F1MXX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4/entry#F1MXX6-1", "sequence": { "sequence": "MPCPRLLAALCGALFCSSGLFAFSGDFCDSSQCLHGGTCLLNEDRTPPFYCLCPEGFTGLLCNETEHGPCFPNPCHNDAECQVTDDSHRGDVFIQYICKCPLGYVGIHCETTCTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIDLGSQKRVTGIITQGARDFGHIQYVAAYRVAYGDDGVTWTEYKDPGASESKIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 431, "header": "tr|F1MXX6-1|A0AAA9TCV4_BOVIN Computationally mapped isoform of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=1 CANONICAL=A0AAA9TCV4-1" }, "locus": { "chromosome": "21", "start_pos": 20482449, "end_pos": 20468082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004272.5", "url": "https://www.ensembl.org/id/ENSBTAT00000004272.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004272.3", "url": "https://www.ensembl.org/id/ENSBTAP00000004272.3" } ] } }, { "isoform_ac": "G3MYW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4/entry#G3MYW7-1", "sequence": { "sequence": "MPCPRLLAALCGALFCSSGLFAFSGPCFPNPCHNDAECQVTDDSHRGDVFIQYICKCPLGYVGIHCETTCTSPLGMQTGAIADSQISASSMHLGFMGLQRWAPELARLHQTGIVNAWTSGNYDKNPWIQVNLMRKMWVTGVVTQGASRAGSAEYLKTFKVAYSTDGRQFQFIQVAGRSGDKIFIGNVNNSGLKINLFDTPLETQYVRLVPIICHRGCTLRFELLGCELNGCTEPLGLKDNTIPNKQITASSYYKTWGLSAFSWFPYYARLDNQGKFNAWTAQTNSASEWLQIFPGNMDNNSHKKNIFETPFQARFVRIQPVAWHNRITLRVELLGC", "length": 336, "header": "tr|G3MYW7-1|G3MYW7_BOVIN Computationally mapped isoform of Milk fat globule EGF and factor V/VIII domain containing OS=Bos taurus OX=9913 GN=MFGE8 PE=4 SV=2 CANONICAL=A0AAA9TCV4-1" }, "locus": { "chromosome": "21", "start_pos": 20482449, "end_pos": 20468082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065341.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065341.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054756.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054756.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FBB9-1", "protein_name": "Milk fat globule EGF and factor V/VIII domain containing", "gene_name": "MFGE8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGPRLLTAICGALLCASGLFAFSGPCFPNPCHNDAECEVIDDAHRGDVFTQYICKCPHGYTGIHCEIICNAPLGMETGAIADFQISASSMHLGFMGLQRWAPELARLHRAGIVNAWTASNYDRNPWIQVNLLRRMRVTGVVTQGASRAGSAEYIKTFKVAYSSDGRKFQFIQGAEESGDKIFMGNLDNSGLKVNLFEVPLEVQYVRLVPIICHRGCTLRFELLGCELSGCAEPLGLKDNTIPNKQITASSFYRTWGLSAFSWYPFYARLDNQGKFNAWTAQSNSASEWLQIDLGSQRRVTGIITQGARDFGHIQYVAAYKVAYSDDGVSWTEYRDQGALEGKIFPGNLDNNSHKKNMFETPFLTRFVRILPVAWHNRITLRVELLGC", "length": 388 }, "evidence": [ { "id": "A0AAA9TCV4", "url": "https://omabrowser.org/oma/group/A0AAA9TCV4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1C0K5-1", "protein_name": "Milk fat globule EGF and factor V/VIII domain containing", "gene_name": "MFGE8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKTVRQWRAPLLLALGLTLLVVVAGDFCSVNYCQNGGTCLTGINETPFFCICPEGFVGIDCNETEKGPCHPNPCHNNGECQLVPNRGDVFTDYICKCPTGYDGVHCQNNKNECSSEPCKNGGTCVDMDGDYACKCPSPFFGKTCHARCAIPLGMEGGAISDAQLSASSVYYGFLGLQRWGPELARLNNHGIVNAWTSSNYDKSPWIQANLLRKMRLSGVITQGARRVGKAEYVRAYKVAYSLDGREFTFYKDEKLNTDKVFQGNVDYGTMQTNMFDPPITAQYIRIYPVVCRRACTLRLELIGCEMNVYFNTAGCSEPLGMKSRLISDQQITASSVFKTWGIDAFTWYPHYARLDKMGKTNAWTALHNDQSEWLQIDLRDQKKVTGIVTQGARDFGHIQYVAAYKVAYSDNGTSWTVYRDSQTNSTKIFHGNSDNYSHKKNVFDVPFHARFVRILPVAWHNRITLRVELLGCDE", "length": 474 }, "evidence": [ { "id": "A0AAA9TCV4", "url": "https://omabrowser.org/oma/group/A0AAA9TCV4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P21956-1", "protein_name": "Lactadherin", "gene_name": "Mfge8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQVSRVLAALCGMLLCASGLFAASGDFCDSSLCLNGGTCLTGQDNDIYCLCPEGFTGLVCNETERGPCSPNPCYNDAKCLVTLDTQRGDIFTEYICQCPVGYSGIHCETETNYYNLDGEYMFTTAVPNTAVPTPAPTPDLSNNLASRCSTQLGMEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRKFEFIQDESGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQMSASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLGC", "length": 463 }, "evidence": [ { "id": "A0AAA9TCV4", "url": "https://omabrowser.org/oma/group/A0AAA9TCV4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC", "length": 387 }, "evidence": [ { "id": "A0AAA9TCV4", "url": "https://omabrowser.org/oma/group/A0AAA9TCV4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "pmid": "" }, { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "apoptotic cell clearance", "id": "GO:0043277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043277", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 67, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TCV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV4" }, { "id": "PS50022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 70, "end_pos": 226, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 351, "end_pos": 353 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TBA2-1", "uniprot_ac": "A0AAA9TBA2", "uniprot_id": "A0AAA9TBA2_BOVIN", "mass": { "chemical_mass": 221848.0, "monoisotopic_mass": 221848.0 }, "refseq": {}, "gene_names": [ { "name": "GSE1", "type": "recommended", "evidence": [ { "id": "A0AAA9TBA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2" } ] } ], "protein_names": [ { "name": "Gse1 coiled-coil protein", "type": "synonym", "evidence": [ { "id": "A0AAA9TBA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GSE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2", "locus": { "chromosome": "18", "start_pos": 11645470, "end_pos": 11252897, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009918", "url": "https://www.ensembl.org/id/ENSBTAG00000009918" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009918", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009918", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IKAMEGP", "url": "https://omabrowser.org/oma/group/IKAMEGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT09", "url": "https://www.orthodb.org/?gene=A0A3Q1LT09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1D7", "url": "https://www.orthodb.org/?gene=A0A3Q1M1D7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2Y6", "url": "https://www.orthodb.org/?gene=A0A3Q1M2Y6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MD23", "url": "https://www.orthodb.org/?gene=A0A3Q1MD23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MVN6", "url": "https://www.orthodb.org/?gene=F1MVN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17608", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17608", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17608:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17608:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12540", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12540", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LT09", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1D7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1D7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Y6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVN6", "url": "https://www.uniprot.org/uniprotkb/F1MVN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVN6-1", "url": "https://www.uniprot.org/uniprotkb/F1MVN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRPAPVSRKQRLMAAVGERTAGGGGAPLSCFICGGGIGRGKELKLQVKQPAAAAGAGAPAQPFFPFLQQQEPAPGARELSPADGCVLVCAVCRCFLGEQWAAFERARTPVDKRMYWLKRPHQCDAGAGGRRGGAAAPREWNVAYALGGADDEDEGGGPGPRAAAEEPRDSELSELSDTDPLSEPDPAARDGPSPHQDGAPAARSAPGPGPRGGRCLEWRPALGPSPGQGAETPASGDVEEEGVPSKLRLDGEPKAGIRRRRKGPGRHWVPEARASVLRGVQDPWQGPSVQVAPAEGTKGAPLGRVAKTPESRPLRESRGGYCMSEDSDINITSEEEDRKEQPLPGPRGPKDKENGSGHAPRVPPESRAAPPEGLCCYICGSALSPASQHQIHVQKQEKLAQAPFFPFLWLHSPPPGAQPISEGGSTLVCPCCFSSLMQQWQSFELANVPVLQRLYVVPLNSHAPGMASKGRRLLREEGPPSGSLPEACYLCGEDCTQDARAVASRSLNGNARASMHFPFLSLLPCPPNAQGPNKRCEVRSCPKCFSVLEDVWALYRACQNEELITSVQGFLGRYHQAFSASDPTLSEPPLSAQGSPASICYICGTELGPGKEFQLNVNPSSRLGEKEPFFPFLTVYPPAPRARPADATGLVATCVLCYHDLLGQWLQHEARGAHHAVSPWSRQYRVETFVCFFCQQEKKRCLGLKAVRVARLPLFLYTLRASHSLLVDDGRQLVIGACIECGTLVCAGQGLPRQAPVGWSSPVAAARKVTSASLETSTATHAPAREPEPRPGAPAESLPRGLRAGQEQGPARCQQSSLDGAGPDLAGTGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARWALPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 2034, "header": "tr|A0AAA9TBA2-1|A0AAA9TBA2_BOVIN Isoform 1 of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0A3Q1LT09-1", "sequence": { "sequence": "MDPKSPTWPALLPGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1215, "header": "tr|A0A3Q1LT09-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11409706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072999.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072999.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060435.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060435.2" } ] } }, { "isoform_ac": "A0A3Q1LVH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0A3Q1LVH5-1", "sequence": { "sequence": "MTPLAERRLRGLSSRWDVSSLKELPRRPPHCGLPQSYLEREGGALGIWGEEGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1253, "header": "tr|A0A3Q1LVH5-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=1 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11600314, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084878.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084878.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061401.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061401.2" } ] } }, { "isoform_ac": "A0A3Q1M1D7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0A3Q1M1D7-1", "sequence": { "sequence": "MFGLKPPLYYLPGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1214, "header": "tr|A0A3Q1M1D7-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11547986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068800.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068800.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063522.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063522.2" } ] } }, { "isoform_ac": "A0A3Q1M2Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0A3Q1M2Y6-1", "sequence": { "sequence": "MFGLKPPLYYLPGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1141, "header": "tr|A0A3Q1M2Y6-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11547986, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072264.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072264.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064406.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064406.2" } ] } }, { "isoform_ac": "A0A3Q1MD23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0A3Q1MD23-1", "sequence": { "sequence": "MLGLKTWSALLQNLSMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1215, "header": "tr|A0A3Q1MD23-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11474128, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081610.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081610.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066708.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066708.2" } ] } }, { "isoform_ac": "A0AAA9TBA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#A0AAA9TBA2-1", "sequence": { "sequence": "MSGRPAPVSRKQRLMAAVGERTAGGGGAPLSCFICGGGIGRGKELKLQVKQPAAAAGAGAPAQPFFPFLQQQEPAPGARELSPADGCVLVCAVCRCFLGEQWAAFERARTPVDKRMYWLKRPHQCDAGAGGRRGGAAAPREWNVAYALGGADDEDEGGGPGPRAAAEEPRDSELSELSDTDPLSEPDPAARDGPSPHQDGAPAARSAPGPGPRGGRCLEWRPALGPSPGQGAETPASGDVEEEGVPSKLRLDGEPKAGIRRRRKGPGRHWVPEARASVLRGVQDPWQGPSVQVAPAEGTKGAPLGRVAKTPESRPLRESRGGYCMSEDSDINITSEEEDRKEQPLPGPRGPKDKENGSGHAPRVPPESRAAPPEGLCCYICGSALSPASQHQIHVQKQEKLAQAPFFPFLWLHSPPPGAQPISEGGSTLVCPCCFSSLMQQWQSFELANVPVLQRLYVVPLNSHAPGMASKGRRLLREEGPPSGSLPEACYLCGEDCTQDARAVASRSLNGNARASMHFPFLSLLPCPPNAQGPNKRCEVRSCPKCFSVLEDVWALYRACQNEELITSVQGFLGRYHQAFSASDPTLSEPPLSAQGSPASICYICGTELGPGKEFQLNVNPSSRLGEKEPFFPFLTVYPPAPRARPADATGLVATCVLCYHDLLGQWLQHEARGAHHAVSPWSRQYRVETFVCFFCQQEKKRCLGLKAVRVARLPLFLYTLRASHSLLVDDGRQLVIGACIECGTLVCAGQGLPRQAPVGWSSPVAAARKVTSASLETSTATHAPAREPEPRPGAPAESLPRGLRAGQEQGPARCQQSSLDGAGPDLAGTGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARWALPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 2034, "header": "tr|A0AAA9TBA2-1|A0AAA9TBA2_BOVIN Isoform 1 of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=2 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11253096, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091722.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091722.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095259.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095259.2" } ] } }, { "isoform_ac": "F1MVN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2/entry#F1MVN6-1", "sequence": { "sequence": "MLLWPQAAIKEIDQQAFGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRGSGGGRERLIVEPPLPQEKAGGPAIPSHLLSSPYPFGISPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRVSSLPPLGLDPATAAAYYHPGYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPAPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQVDEELRREREREREREADREREKEREREREKEREREKELEREKERELERQREQRAREKELLAAKALEPAFLPVAELHALRSHAAEERAKPSEQLTPTRAEKLKDAGLQVPKPVQHPLHPAAAPPHAAPGLLAGHGLFSLPGSSAATALLLQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQQLDLGRPPAPADPEHRPESARPGPNRHEPGSREPPQHFGGPPPLISPKPQHHSMPTALWNPVSLMDSSLEPRRAPEGHPPHGHPAPFEPSRPAAVPLVKVERVYCPEKAEEGPRKREATPLDKYPPPPPREPGALEPQAFPPGPGPFLAELEPAAPTVLGQPRASLAPPAAFGEPPGPLKPGSPYRPLPPRGPDPAYVYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEDLLTQKRRKRRRMLRERSPSPPTARSKRQTPSPRLALSTRYSPDDMNSSPNFEEKKKFLTIFNLTHISAEKRKDKERLVELLQAMKQKALSAAVADPLRTSPRDSPAVSVSEPTTQQASLDTEKPVGIAASLSDVPKATEPGRLEQLRPPERIQEPAPTSGEKARPSEAPGGKKSLSMLHYVRGPAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSAAVLSAEQNHKVDASVHYNLPELQSSSRLPPPQHNGQQEPPASRKGPLAQEMDPDSEEEDDGEDDDEDPPRRKWQGIEAILEAYQEHVEEQDLERQVLQAQCRRLEAQHYSLSLTAEQLSHSMAELRSQKQKIVSERERLQAELDHLRKCLALPAMHWPRGYFKGYPR", "length": 1218, "header": "tr|F1MVN6-1|A0AAA9TBA2_BOVIN Computationally mapped isoform of Gse1 coiled-coil protein OS=Bos taurus OX=9913 GN=GSE1 PE=4 SV=4 CANONICAL=A0AAA9TBA2-1" }, "locus": { "chromosome": "18", "start_pos": 11644466, "end_pos": 11606463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013088.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013088.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013088.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013088.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1790, "start_aa": "Thr", "end_pos": 1790, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1790", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AG34-1", "protein_name": "Gse1 coiled-coil protein", "gene_name": "Gse1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFGLKPPLYYLPGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLNGALVPTGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDSGSRGGSSGRERLLVEPPLAQEKAAGPAIPSHLLSTPYPFGLSPSSVVQDSRFQPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRMSSLPPLGLDPATAAAYYHPSYLTPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERISSLSAERLQMDEELRREREREREREREADREREKEREREQREKEREKELEREREKERERELERQREQRAREKELLAAKALEPTFLPVAELHGLRGHTTEERPKPSEQLTPTRAEKLKDTGVQAPKPVQHPLHPVPAPHHTVPSLISSHGIFSLPGSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDLGRPLVPTEAEHRPESTRPGPNRHDQGSREPPQHFGGPPPLISPKPQHHTVPTALWNPVSLMDNTLETRRAESHSLHSHPTAFEPSRQAAVPLVKVERVYCTEKAEEPRKREATPLDKYQPPPPPPPPPPREAGGLEPQTFPHGPGPFLAELEKSTQTILGQQRPSLSQTTPFGELTGSLKSGSPYCHTTARGPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPAIQCKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHISAEKRKDKERLVEMLRAMKQRALSAAVADSVATNSSRDSPTISLSEPATQPAPLETDQPAGVPASLSDVPKAVETGRLEQLRPQELLRVQEPAPPSGEKARLSEAPGGKKNLSMLHYLRGAAPKDIPVPLSHSINGKSKPWEPFMAEEFAHQFHESVLQSTQKALQKHKGSSALLSAEQNHKVDTSVHYNIPELQSSSRVPLPQHNGQQEPPAGRKGPPMQEVDQDSEDDSEEEAEEAPRHQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAELRSQKQKMVSERERLQAELDHLRKCLALPTMHWPRGYFKGYPR", "length": 1223 }, "evidence": [ { "id": "A0AAA9TBA2", "url": "https://omabrowser.org/oma/group/A0AAA9TBA2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14687-1", "protein_name": "Genetic suppressor element 1", "gene_name": "GSE1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLKGYPR", "length": 1217 }, "evidence": [ { "id": "A0AAA9TBA2", "url": "https://omabrowser.org/oma/group/A0AAA9TBA2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LWL6-1", "protein_name": "Genetic suppressor element 1", "gene_name": "gse1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSHEPKSPSLGMISTATRTTATVSPLTPSPLNGSIVPNVSPASQSAHSGFAAALRKLAKQAEEPRGSSISSESSPVSSPATNHSSPVSTPKRGPMGPVIVPPGGHSVPSTPPVVTIAPTKTVNGLWRSESRSVREVESVPHGVSRDRLSSEAASAQEKGGPTVPAHLIGNPYPFGLTPASVMQDSRFQPLNLPRQMPHAVPTASVPEEYLRGFRPYATAEELRMPSLPLGLDPATAAAAAAYYHPGYLPHPSFSHYRMDDPFCLSALRSPFYQLPAGGALPPLHPSAVHMHLPGVRYPGDLSHPSLSSLQSERLSERLQMEDELRQREREREREREKEREREAEREKEREREREREKELEREREREREREREKEREREREMERQKERAAREKAAESHYLTELHGLRGAPDDRAKPDRITSNRPEKTKESILTTPKPIQPGIHQSLNSTHHPVPSLSSAHGLYLGPGGAGPTSLTVATMLQRTEEERWLARQRKLRQEKEDRQYQVSEFRQQVLEQHLDLGRQGEIPDMNVEGHRPVPNHHEPSSRDRDRDRDSHPLLGAPPPLISPKHQHKDHAPPPPTTLWNPAALIETSTDSRRTLHDPPSLGHYDISRLPLPPSKHERHYNSEKLEEGSRKRDSLDKYPPIRPSGFSEPNTFLAELEKSTQSFLNQQRAPLSLSGPYGELSAGFKSSGPLKNLQGHSRLAPDTTLVYDEFLQQHRRAVSKLDLEERRRREAREKGYYYELDDSYDESDEEEVRAHLRRVSEQPPLKLDDSTEKVEFLEMFDLTTLAHREEMMEVKRKKRRRMLRERSPSPPTVQNKRPTPTPLLTRFTPEDMNNSPELEDKKRFLTIFSLNHITQQQRRDNERVEELLQAIKQKSVTLDTIRHNPHPLCRSPAAHSSDQSSQSPVQSEELLNGWPLSPSPSVSIPQPSADPLSISDQHRPLSDPPKPKDSSLPPALPDKCRANDSLPGKSSSLLNSLRQPPFAKESSVSVNGKTKPWENFIAEEFAQQFHESVLQSTQKALQKSKGGALVVLEQNHAVDSSVHYNIPELQSTPGRSKPHPHPPSSQPNGQHCPPQPSRQELSAEESEEEEEEDDTEEDEPSTSRWQGIEAIFEAYQEYAEEQSIERQVLHSQCRRLEAHHYNLSLTAEQLSHSMGELMAQKQKLAAERENLQAELEHFKKCLTLPQSPWSRAHFKGYPPR", "length": 1203 }, "evidence": [ { "id": "A0AAA9TBA2", "url": "https://omabrowser.org/oma/group/A0AAA9TBA2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3U3C9-1", "protein_name": "Genetic suppressor element 1", "gene_name": "Gse1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLNGALVPTGSPATSSTLSAQAAPSSSFAAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDSGSRGSSSGRERLLVEPPLAQEKAAGPAIPSHLLSTPYPFGLSPGSVVQDSRFQPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSLSAERLQMDEELRREREREREREREADREREKEREREQREKEREKELEREREKERERELERQREQRAREKELLAAKALEPTTFLPVAELHGLRGHSTEERPKPSEQLTPTRAEKLKDVGLQAPKPVQHPLHPVPAPHHTVPSLISSHGIFSLPGSSATTALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDLGRPLVPTEAEHRPESTRPGTNRHEQGSREPPQHFGGPPPLISPKPQQHTVPTALWNPVSLMDNALETRRAESHSLHSHPTAFEPSRQAAVPLVKVERVYCSEKAEEPRKREATPLDKYQPPPPPPPPREAGSLEPQTFPHGPGPFLTELEKSTQTILGQQRPSLSQATSFGELSGPLKPGSPYCHPTARGPDPAYIYDEFLQQRRKLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPAVQCKRQTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHISAEKRKDKERLVEMLRAMKQRALSAADSVTNSSRDSPPVSLSEPATQPAPLETDQPVGVPASLSDVPKTTETGRLEQLRPQELLRVQEPAPPSGEKARLSEAPGGKKSLSMLHYLRGAAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQKALQKHKGNSALLSAEQSHKVDTAIHYNIPELQSSSRVPLPQHNGQQEPPMGRKGPPMQEADQDSEEDSEEDSEEEAEEAPRRQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQLSHSMAELRSQKQKMVSERERLQAELDHLRKCLALPTMHWPRGYFKGYPR", "length": 1213 }, "evidence": [ { "id": "A0AAA9TBA2", "url": "https://omabrowser.org/oma/group/A0AAA9TBA2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1678, "end_pos": 1680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1694, "end_pos": 1696, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 920, "end_pos": 922, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA2" }, { "id": "PF12540", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12540" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Genetic suppressor element-like", "eco_id": "ECO_0000259", "start_pos": 1555, "end_pos": 1696, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1790 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1678, "end_pos": 1680 }, { "start_pos": 1694, "end_pos": 1696 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 920, "end_pos": 922 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": 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"count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TC43-1", "uniprot_ac": "A0AAA9TC43", "uniprot_id": "A0AAA9TC43_BOVIN", "mass": { "chemical_mass": 56390.0, "monoisotopic_mass": 56390.0 }, "refseq": { "ac": "XP_005202462", "name": "voltage-dependent L-type calcium channel subunit beta-4 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202462" }, "gene_names": [ { "name": "CACNB4", "type": "recommended", "evidence": [ { "id": "A0AAA9TC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ] }, { "name": "CACNB4", "type": "synonym", "evidence": [ { "id": "XP_005202462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202462" } ] } ], "protein_names": [ { "name": "Voltage-dependent L-type calcium channel subunit beta-4", "type": "recommended", "evidence": [ { "id": "A0AAA9TC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#names_and_taxonomy" } ] }, { "name": "Calcium channel voltage-dependent subunit beta 4", "type": "synonym", "evidence": [ { "id": "A0AAA9TC43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#names_and_taxonomy" } ] }, { "name": "voltage-dependent L-type calcium channel subunit beta-4 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202462", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202462" } ] } ], "function": [ { "annotation": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S3P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P3#function" }, { "database": "UniProtKB", "id": "ARBA00045432", "url": "https://www.uniprot.org/uniprotkb/ARBA00045432#function" }, { "database": "UniProtKB", "id": "A0AAA9S3Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Z8#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN2#function" } ] }, { "annotation": "The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT41#function" }, { "database": "UniProtKB", "id": "ARBA00002749", "url": "https://www.uniprot.org/uniprotkb/ARBA00002749#function" }, { "database": "UniProtKB", "id": "A0AAA9S3P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P3#function" }, { "database": "UniProtKB", "id": "A0AAA9S3Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Z8#function" }, { "database": "UniProtKB", "id": "A0AAA9SCF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF4#function" }, { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CACNB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43", "locus": { "chromosome": "2", "start_pos": 44345827, "end_pos": 44072796, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002297", "url": "https://www.ensembl.org/id/ENSBTAG00000002297" } ] } } ], "crossref": [ { "id": "A0AAA9TC43", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TC43", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002297", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002297", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12043", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12043", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282161", "url": "https://www.ncbi.nlm.nih.gov/gene/282161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282161", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282161", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WRSTHAS", "url": "https://omabrowser.org/oma/group/WRSTHAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N167", "url": "https://www.orthodb.org/?gene=F1N167", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11824", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112308", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112308", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005202462", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202462", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6E5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6E5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6E5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6E5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3P3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKI4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N167", "url": "https://www.uniprot.org/uniprotkb/F1N167", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N167-1", "url": "https://www.uniprot.org/uniprotkb/F1N167-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 502, "header": "tr|A0AAA9TC43-1|A0AAA9TC43_BOVIN Isoform 1 of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0A3Q1LT41-1", "sequence": { "sequence": "MAGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 473, "header": "tr|A0A3Q1LT41-1|A0AAA9TC43_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=2 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44203803, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075836.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075836.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063601.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063601.2" } ] } }, { "isoform_ac": "A0A3Q1LYN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0A3Q1LYN2-1", "sequence": { "sequence": "MYDNLYLHGIEDSEAGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 392, "header": "tr|A0A3Q1LYN2-1|A0A3Q1LYN2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-3 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=2 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44201687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086811.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086811.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060749.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060749.2" } ] } }, { "isoform_ac": "A0A3Q1M6E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0A3Q1M6E5-1", "sequence": { "sequence": "MAGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 441, "header": "tr|A0A3Q1M6E5-1|A0AAA9TC43_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=2 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44203803, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076691.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076691.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063877.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063877.2" } ] } }, { "isoform_ac": "A0AAA9S3P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0AAA9S3P3-1", "sequence": { "sequence": "MYDNLYLHGIEDSEAGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 407, "header": "tr|A0AAA9S3P3-1|A0AAA9TC43_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44201687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112327.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112327.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080557.1" } ] } }, { "isoform_ac": "A0AAA9S3Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0AAA9S3Z8-1", "sequence": { "sequence": "MYDNLYLHGIEDSEAGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 486, "header": "tr|A0AAA9S3Z8-1|A0AAA9TC43_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44201687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080664.1" } ] } }, { "isoform_ac": "A0AAA9SCF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0AAA9SCF4-1", "sequence": { "sequence": "MSSSSYAKNGSADRPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 520, "header": "tr|A0AAA9SCF4-1|A0AAA9TC43_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44073031, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134706.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134706.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079920.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079920.1" } ] } }, { "isoform_ac": "A0AAA9TC43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0AAA9TC43-1", "sequence": { "sequence": "MDVVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 502, "header": "tr|A0AAA9TC43-1|A0AAA9TC43_BOVIN Isoform 1 of Voltage-dependent L-type calcium channel subunit beta-4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44073345, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090222.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090222.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094287.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094287.1" } ] } }, { "isoform_ac": "A0AAA9TKI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#A0AAA9TKI4-1", "sequence": { "sequence": "MSSSSYAKNGSADRPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 479, "header": "tr|A0AAA9TKI4-1|A0AAA9TKI4_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit beta 4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=1 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44073031, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121003.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121003.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097694.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097694.1" } ] } }, { "isoform_ac": "F1N167-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43/entry#F1N167-1", "sequence": { "sequence": "MSSSSYAKNGSADRPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPSQRLRHSNHSTENSPVERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 458, "header": "tr|F1N167-1|F1N167_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit beta 4 OS=Bos taurus OX=9913 GN=CACNB4 PE=3 SV=3 CANONICAL=A0AAA9TC43-1" }, "locus": { "chromosome": "2", "start_pos": 44344823, "end_pos": 44073031, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002971.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002971.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002971.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002971.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282161", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282161", "resource": "KEGG Pathway" }, { "id": "R-BTA-112308", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112308", "resource": "Reactome", "description": "Presynaptic depolarization and calcium channel opening" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A055-2", "protein_name": "Voltage-dependent L-type calcium channel subunit beta-4", "gene_name": "Cacnb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSSYAKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTTTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTSSSTPMTPLLGRNVGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGCSHDSRHRL", "length": 519 }, "evidence": [ { "id": "A0AAA9TC43", "url": "https://omabrowser.org/oma/group/A0AAA9TC43/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O00305-1", "protein_name": "Voltage-dependent L-type calcium channel subunit beta-4", "gene_name": "CACNB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL", "length": 520 }, "evidence": [ { "id": "A0AAA9TC43", "url": "https://omabrowser.org/oma/group/A0AAA9TC43/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "voltage-gated calcium channel complex", "id": "GO:0005891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005891", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "voltage-gated calcium channel activity", "id": "GO:0005245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "calcium channel regulator activity", "id": "GO:0005246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005246", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "id": "GO:0099626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099626", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "high voltage-gated calcium channel activity", "id": "GO:0008331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008331", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of synaptic vesicle exocytosis", "id": "GO:2000300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": 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] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX18", "url": "https://www.orthodb.org/?gene=A0A3Q1LX18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCQ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MCQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LX18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX18-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S079", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S079", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S079-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S079-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKEDPLEKEMATHFSILAWRIHGRRSPAGCGPWTQSRTRLSTHTITWAGRYSHGHFSGEDTETQQGSSLPEVIWRSHVQPRRLVWCGGRAVATLLNCLVPRQRQTQTPGLRRTMWAVLPTFRSTCSGG", "length": 736, "header": "tr|A0AAA9TBE0-1|A0AAA9TBE0_BOVIN Isoform 1 of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0A3Q1LX18-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKVDRGGPPREVREAGRALTRWPRGDLPFTQFLARLAVWRCLGAALLPAGQDTCPVFPQSPGCKSQSCRCCGPQIVPSASPFQVGSSHHRLGRSLQVIWTVLSPHPGLTVVSAALPAPGTTCVNSFTLQKRQMLTLGNT", "length": 724, "header": "tr|A0A3Q1LX18-1|A0AAA9TBE0_BOVIN Computationally mapped isoform of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=2 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98213617, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079242.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079242.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062010.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062010.2" } ] } }, { "isoform_ac": "A0A3Q1MCQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0A3Q1MCQ0-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKVGVSEAGLQHEILRRAQELLDAARAQPELLKPPEGGVLPTAPEELPEAVRPSAPPAELLEVQTSECVVCLEREAQMIFLNCGHVCCCQPCSQPLRTCPLCRQDITQRLRIYHSS", "length": 705, "header": "tr|A0A3Q1MCQ0-1|A0AAA9TBE0_BOVIN Computationally mapped isoform of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=2 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98217161, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067503.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067503.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068147.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068147.2" } ] } }, { "isoform_ac": "A0AAA9S079-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0AAA9S079-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKVGVSEAGLQHEILRRAQELLDAARAQPELLKPPEGGVLPTAPEELPEAVRPSAPPAELLEVQTSECVVCLEREAQMIFLNCGHVCCCQPCSQPLRTCPLCRQDITQRLRIYHSS", "length": 709, "header": "tr|A0AAA9S079-1|A0AAA9TBE0_BOVIN Computationally mapped isoform of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98217161, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122810.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122810.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079251.1" } ] } }, { "isoform_ac": "A0AAA9SZA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0AAA9SZA3-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKVGVSEAGLQHEILRRAQELLDAARAQPELLKPPEGGVLPTAPEELPEAVRPSAPPAELLEVQTSECVVCLEREAQMIFLNCGHVCCCQPCSQPLRTCPLCRQDITQRLRIYHSS", "length": 691, "header": "tr|A0AAA9SZA3-1|A0AAA9TBE0_BOVIN Computationally mapped isoform of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98217161, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091781.1" } ] } }, { "isoform_ac": "A0AAA9TBE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0AAA9TBE0-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQIKLIETELLQLTQLELKRKSLDTEALQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKEDPLEKEMATHFSILAWRIHGRRSPAGCGPWTQSRTRLSTHTITWAGRYSHGHFSGEDTETQQGSSLPEVIWRSHVQPRRLVWCGGRAVATLLNCLVPRQRQTQTPGLRRTMWAVLPTFRSTCSGG", "length": 736, "header": "tr|A0AAA9TBE0-1|A0AAA9TBE0_BOVIN Isoform 1 of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98214181, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088191.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088191.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093399.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093399.1" } ] } }, { "isoform_ac": "A0AAA9THH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0AAA9THH4-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSSMADMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRKQEMISEQRWALSSLLQQLLKEKTQREEELREILTELEAQSETKQENYWLIQYQRLLNQKPLSLKLQEEGLERPLVALLVELSAEHYLPIFAHHRLSLAMLSRMGPADLAKVGVSEAGLQHEILRRAQELLDAARAQPELLKPPEGGVLPTAPEELPEAVRPSAPPAELLEVQTSECVVCLEREAQMIFLNCGHVCCCQPCSQPLRTCPLCRQDITQRLRIYHSS", "length": 697, "header": "tr|A0AAA9THH4-1|A0AAA9THH4_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase LRSAM1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98217161, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096532.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096532.1" } ] } }, { "isoform_ac": "A0AAA9TQN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0/entry#A0AAA9TQN0-1", "sequence": { "sequence": "MPLFFRKRKPSDEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNVLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDIGQLTALQVLNMERNQLTYLPRSIGNLIQLQTLNVKDNRLKELPDTLGELRSLRTLDISENEIQRLPRMLAHVRTLETLSLDALSMVYPPQEVCGAGTEAIQQFLCKESGLEYYPPSQYLLPVLEQDGAENSLDSPDGPTDRLCREEEEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHAQLLQQSNSQKDEILQTVKEEQSRLEQGLSEHQRFLDAERRRLQEQLKQTEQNISNRIQKLLQENQRQKKSSEILKSLENERIRMEQLMSITQEETENLRRREIASAMQQMLTESCKSRLIQMAYESQRQNLVQQACSRTWPPVGAP", "length": 428, "header": "tr|A0AAA9TQN0-1|A0AAA9TQN0_BOVIN Computationally mapped isoform of Leucine rich repeat and sterile alpha motif containing 1 OS=Bos taurus OX=9913 GN=LRSAM1 PE=4 SV=1 CANONICAL=A0AAA9TBE0-1" }, "locus": { "chromosome": "11", "start_pos": 98206655, "end_pos": 98186135, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111930.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111930.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098730.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "negative regulation of endocytosis", "id": "GO:0045806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045806", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "viral budding", "id": "GO:0046755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046755", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "ubiquitin-dependent endocytosis", "id": "GO:0070086", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070086", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" }, { "name": "positive regulation of xenophagy", "id": "GO:1904417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 239 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 334, "end_pos": 336 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCS9-1", "uniprot_ac": "A0AAA9TCS9", "uniprot_id": "A0AAA9TCS9_BOVIN", "mass": { "chemical_mass": 94254.0, "monoisotopic_mass": 94254.0 }, "refseq": {}, "gene_names": [ { "name": "AP5Z1", "type": "recommended", "evidence": [ { "id": "A0AAA9TCS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ] } ], "protein_names": [ { "name": "Adaptor related protein complex 5 subunit zeta 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TCS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP5Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9", "locus": { "chromosome": "25", "start_pos": 39191689, "end_pos": 39208004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012197", "url": "https://www.ensembl.org/id/ENSBTAG00000012197" } ] } } ], "crossref": [ { "id": "A0AAA9TCS9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012197", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012197", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512522", "url": "https://www.ncbi.nlm.nih.gov/gene/512522", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028222", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028222", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LMLAYEF", "url": "https://omabrowser.org/oma/group/LMLAYEF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXJ6", "url": "https://www.orthodb.org/?gene=A0A3Q1LXJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MZR9", "url": "https://www.orthodb.org/?gene=F1MZR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46488", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46488", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46488:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46488:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14764", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14764", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LXJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZR9", "url": "https://www.uniprot.org/uniprotkb/F1MZR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZR9-1", "url": "https://www.uniprot.org/uniprotkb/F1MZR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHAARPGSRRRCGHCFASRPCLERAARPQGGGGGGMLATGTESLLRQAREVGAEELGRFCARVSALLQAEDWGPDALDALRRLFLIVAATKYSRRLEPTCVALLQTTLCSPRCPERLQLLCAAVLREMAPSDSLSLSCDHAQSSRQLGLVASVLLAQGDPQQVRTVGQCVIKVLESRQPEGPSLTYLLPVVSKVTSLAPDALPEEQTKALSKRLGEWLRYASVQQGAAHASGGFFSTPRARQPGPVTEVDGTVATDFFTVLSTGQRFTEDQRLNVQAFSMLRAWLLQGGPARPGAADADDRSELEGSTVSVLSAASAASHLLPPAEWLREKALEYCQRLLEQSGRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRALPCVRALRTRLCGDTACVRALLPIAQFFLHHGEAAAVDADAVCQHLFTRIPSEHFHSPMLAFEFVQFCRDHLVLFGSNLDLLRTSFPNLFKFLAWSSPALTSGFVALLPVLVDAGTAVEMLHLLLDLPSLTAALDLQLRASQAASERPLWDVSVRAPGCLEALRDPQAQGLFQHLLRAKASGTVERLTPLHQLLQPLASCARVLQCAQAVPTLLRAFFAAVTQFASGALASQLALLLLERSDSLFQVEGYEADVHRVLSSQFPALCKLHPPLVVERAKELLEFVGSLGGPRSTGHMLTSVVWAVGEYLSVSWDRRCSAEQISRFFEALEALLFEVTQSRPSAALPKCPPQVITVLMTTLTKLASRSQDLIPRVSLLLSKMRTLAQSPAVGPVHGEDDLGAVRTRATELLNLLKMPSVAQFVLTPSVEVSQPRYHRDCNTALPLALDMVSRLLEREAGLLPGTRPPQHLPLEAVPGRSRALCSSPE", "length": 867, "header": "tr|A0AAA9TCS9-1|A0AAA9TCS9_BOVIN Isoform 1 of Adaptor related protein complex 5 subunit zeta 1 OS=Bos taurus OX=9913 GN=AP5Z1 PE=4 SV=1 CANONICAL=A0AAA9TCS9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9/entry#A0A3Q1LXJ6-1", "sequence": { "sequence": "MRHAARPGSRRRCGHCFASRPCLERAARPQGGGGGGMLATGTESLLRQASVCLILVSREVGAEELGRFCARVSALLQAEDWGPDALDALRRLFLIVAATKYSRRLEPTCVALLQTTLCSPRCPERLQLLCAAVLREMAPSDSLSLSCDHAQSSRQLGLVASVLLAQGDPQQVRTVGQCVIKVLESRQPEGPSLTYLLPVVSKVTSLAPDALPEEQTKALSKRLGEWLRYASVQQGAAHASGGFFSTPRARQPGPVTEVDGTVATDFFTVLSTGQRFTEDQRLNVQAFSMLRAWLLQGGPARPGAADADDRSELEGSTVSVLSAASAASHLLPPAEWLREKALEYCQRLLEQSGRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRALPCVRALRTRLCGDTACVRALLPIAQFFLHHGEAAAVDADAVCQHLFTRIPSEHFHSPMLAFEFVQFCRDHLVLFGSNLDLLRTSFPNLFKFLAWSSPALTSGFVALLPVLVDAGTAVEMLHLLLDLPSLTAALDLQLRASQAASERPLWDVSVRAPGCLEALRDPQAQGLFQHLLRAKASGTVERLTPLHQLLQPLASCARVLQCAQAVPTLLRAFFAAVTQFASGALASQLALLLLERSDSLFQVEGYEADVHRVLSSQFPALCKLHPPLVVERAKELLEFVGSLGGPRSTGHMLTSVVWAVGEYLSVSWDRRCSAEQISRFFEALEALLFEVTQSRPSAALPKCPPQVITVLMTTLTKLASRSQDLIPRVSLLLSKMRTLAQSPAVGPVHGEDDLGAVRTRATELLNLLKMPSVAQFVLTPSVEVSQPRYHRDCNTALPLALDMVSRLLEREAGLLPG", "length": 851, "header": "tr|A0A3Q1LXJ6-1|A0AAA9TCS9_BOVIN Computationally mapped isoform of Adaptor related protein complex 5 subunit zeta 1 OS=Bos taurus OX=9913 GN=AP5Z1 PE=4 SV=2 CANONICAL=A0AAA9TCS9-1" }, "locus": { "chromosome": "25", "start_pos": 39207805, "end_pos": 39192364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067377.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067377.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065503.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065503.2" } ] } }, { "isoform_ac": "A0AAA9SI73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9/entry#A0AAA9SI73-1", "sequence": { "sequence": "MRHAARPGSRRRCGHCFASRPCLERAARPQGGGGGGMLATGTESLLRQAREVGAEELGRFCARVSALLQAEDWGPDALDALRRLFLIVAATKYSRRLEPTCVALLQTTLCSPRCPERLQLLCAAVLREMAPSDSLSLSCDHAQSSRQLGLVASVLLAQGDPQQVRTVGQCVIKVLESRQPEGPSLTYLLPVVSKVTSLAPDALPEEQTKALSKRLGEWLRYASVQQGAAHASGGFFSTPRARQPGPVTEVDGTVATDFFTVLSTGQRFTEDQRLNVQAFSMLRAWLLQGGPARPGAADADDRSELEGSTVSVLSAASAASHLLPPAEWLREKALEYCQRLLEQSGRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRALPCVRALRTRLCGDTACVRALLPIAQFFLHHGEAAAVDADAVCQHLFTRIPSEHFHSPMLAFEFVQFCRDHLVLFGSNLDLLRTSFPNLFKFLAWSSPALTSGFVALLPVLVDAGTAVEMLHLLLDLPSLTAALDLQLRASQAASERPLWDVSVRAPGCLEALRDPQAQGLFQHLLRAKASGTVERLTPLHQLLQPLASCARVLQCAQAVPTLLRAFFAAVTQFASGALASQLALLLLERSDSLFQVEGYEADVHRVLSSQFPALCKLHPPLVVERAKELLEFVGSLGGPRSTGHMLTSVVWAVGEYLSVSWDRRCSAEQISRFFEALEALLFEVTQSRPSAALPKCPPQVITVLMTTLTKLASRSQDLIPRVSLLLSKMRTLAQSPAVGPVHGEDDLGAVRTRATELLNLLKMPSVAQFVLTPSVEVSQPRYHRDCNTALPLALDMVSRLLEREAGLLPG", "length": 843, "header": "tr|A0AAA9SI73-1|A0AAA9TCS9_BOVIN Computationally mapped isoform of Adaptor related protein complex 5 subunit zeta 1 OS=Bos taurus OX=9913 GN=AP5Z1 PE=4 SV=1 CANONICAL=A0AAA9TCS9-1" }, "locus": { "chromosome": "25", "start_pos": 39207805, "end_pos": 39192364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093368.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093368.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085935.1" } ] } }, { "isoform_ac": "A0AAA9TCS9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9/entry#A0AAA9TCS9-1", "sequence": { "sequence": "MRHAARPGSRRRCGHCFASRPCLERAARPQGGGGGGMLATGTESLLRQAREVGAEELGRFCARVSALLQAEDWGPDALDALRRLFLIVAATKYSRRLEPTCVALLQTTLCSPRCPERLQLLCAAVLREMAPSDSLSLSCDHAQSSRQLGLVASVLLAQGDPQQVRTVGQCVIKVLESRQPEGPSLTYLLPVVSKVTSLAPDALPEEQTKALSKRLGEWLRYASVQQGAAHASGGFFSTPRARQPGPVTEVDGTVATDFFTVLSTGQRFTEDQRLNVQAFSMLRAWLLQGGPARPGAADADDRSELEGSTVSVLSAASAASHLLPPAEWLREKALEYCQRLLEQSGRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRALPCVRALRTRLCGDTACVRALLPIAQFFLHHGEAAAVDADAVCQHLFTRIPSEHFHSPMLAFEFVQFCRDHLVLFGSNLDLLRTSFPNLFKFLAWSSPALTSGFVALLPVLVDAGTAVEMLHLLLDLPSLTAALDLQLRASQAASERPLWDVSVRAPGCLEALRDPQAQGLFQHLLRAKASGTVERLTPLHQLLQPLASCARVLQCAQAVPTLLRAFFAAVTQFASGALASQLALLLLERSDSLFQVEGYEADVHRVLSSQFPALCKLHPPLVVERAKELLEFVGSLGGPRSTGHMLTSVVWAVGEYLSVSWDRRCSAEQISRFFEALEALLFEVTQSRPSAALPKCPPQVITVLMTTLTKLASRSQDLIPRVSLLLSKMRTLAQSPAVGPVHGEDDLGAVRTRATELLNLLKMPSVAQFVLTPSVEVSQPRYHRDCNTALPLALDMVSRLLEREAGLLPGTRPPQHLPLEAVPGRSRALCSSPE", "length": 867, "header": "tr|A0AAA9TCS9-1|A0AAA9TCS9_BOVIN Isoform 1 of Adaptor related protein complex 5 subunit zeta 1 OS=Bos taurus OX=9913 GN=AP5Z1 PE=4 SV=1 CANONICAL=A0AAA9TCS9-1" }, "locus": { "chromosome": "25", "start_pos": 39207805, "end_pos": 39191748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128369.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128369.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093939.1" } ] } }, { "isoform_ac": "F1MZR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9/entry#F1MZR9-1", "sequence": { "sequence": "MLLEEKQRRPEPWFKGKSREVGAEELGRFCARVSALLQAEDWGPDALDALRRLFLIVAATKYSRRLEPTCVALLQTTLCSPRCPERLQLLCAAVLREMAPSDSLSLSCDHAQSSRQLGLVASVLLAQGDPQQVRTVGQCVIKVLESRQPEGPSLTYLLPVVSKVTSLAPDALPEEQTKALSKRLGEWLRYASVQQGAAHASGGFFSTPRARQPGPVTEVDGTVATDFFTVLSTGQRFTEDQRLNVQAFSMLRAWLLQGGPARPGAADADDRSELEGSTVSVLSAASAASHLLPPAEWLREKALEYCQRLLEQSGRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRALPCVRALRTRLCGDTACVRALLPIAQFFLHHGEAAAVDADAVCQHLFTRIPSEHFHSPMLAFEFVQFCRDHLVLFGSNLDLLRTSFPNLFKFLAWSSPALTSGFVALLPVLVDAGTAVEMLHLLLDLPSLTAALDLQLRASQAASERPLWDVSVRAPGCLEALRDPQAQGLFQHLLRAKASGTVERLTPLHQLLQPLASCARVLQCAQAVPTLLRAFFAAVTQFASGALASQLALLLLERSDSLFQVEGYEADVHRVLSSQFPALCKLHPPLVVERAKELLEFVGSLGGPRSTGHMLTSVVWAVGEYLSVSWDRRCSAEQISRFFEALEALLFEVTQSRPSAALPKCPPQVITVLMTTLTKLASRSQDLIPRVSLLLSKMRTLAQSPAVGPVHGEDDLGAVRTRATELLNLLKMPSVAQFVLTPSVEVSQPRYHRDCNTALPLALDMVSRLLEREAGLLPG", "length": 812, "header": "tr|F1MZR9-1|A0AAA9TCS9_BOVIN Computationally mapped isoform of Adaptor related protein complex 5 subunit zeta 1 OS=Bos taurus OX=9913 GN=AP5Z1 PE=4 SV=2 CANONICAL=A0AAA9TCS9-1" }, "locus": { "chromosome": "25", "start_pos": 39207170, "end_pos": 39192364, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016176.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016176.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016176.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016176.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JYJ5-1", "protein_name": "Adaptor related protein complex 5 subunit zeta 1", "gene_name": "Ap5z1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSAGAESLLHQAREIQDEELQRFCSRVTKLLQEAPGPATVDALQRLFLIVSSTKYPRRLEKACVDLLQTTLCLPTSPEQLQVLCAAILREMSPFNDLTLSCDHTQNTRQLSLVASVLLAQGDRNGEIRQVSQRIFKILENRQPEGPSVRPLLPVLSKVIGLAPGILVEDQTNLLSKRLVDWLRYASIQQGLPYSGGFFSTPRTRQPGPITEVDGAVASDFFTVLSTGQHFTEDQWVNMQAFSMLRKWLLHSGPEDPGSPDADDKSELEGSMLSVLSAASTASRLLPPRERLREVAFEYCQRLLEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRTLSCLKPLHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEAIYAQLLGSLPSERFHSPTLAFEVIHFCTHNLALFDPHFLSLLRLSFPNLFKFLAWNSPPLTAEFVVLLPALVDAGTAVEMLHALLDLPCLTAALDLQLRSTQTPSERPLWDVSLRVPSCLEAFQDPQFQGLFRHLLRTKASGSTERLTPLHQVLKPMASCARVAQCVEAIPVLLQAFFSAVTQTADGPLINQLALLLLERSDSLYPVPQYEARVHRVLSSQLLVLCKLKPSLVVELSRELLEFVGSVSSIRSRASMFTCVVWAIGEYLSVTCDKRCTAEQINKFFEALEALLFEVTQSRPSADLPCCPPELVTALMTTLTKLASRSQDLIPRVSLFLSKMRTLAQNPATSSMHSEEDTESIRIRATELLTLLKMPSVAQFVFTPTVGVCQPRYHQDTNVALPLALRTVSRLVEKEAGLLPG", "length": 807 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2N0C1-1", "protein_name": "AP-5 complex subunit zeta-1 isoform X1", "gene_name": "Ap5z1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFSAGAESLLHQAREIQDEELQRFCTRVTKLLQEPPGPATMDALQRLFLIVSATKYPRRLEKMCVDLFQTTLCLPTSPEQLQVLCAAILREMSPFDDLALSCDHTQNTRQLSLVASVLLAQGNRKGEIRQVSQRIFKILENRQPEGPSVRHLLPALSKVIGLAPGTLMEDQNNLLSKRLVDWLRYASIQQGLPSSAGFFSTPRTRQPGPITEVDGAVASDFFTVLSTGQHFTEDQWLNMQAFSMLRKWLLHSGPEDPGSPDADDKSELEGSTLSVLSAASTASRLLPPRERLREVAFEYCQRLLEQSNRRALRKADSDLQKACLVEAVLVLDVLCRQDPSFLYRTLSCLKALHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEVIYQHLLSRLPSERFYSPTLAFEVIHFCTHNLALFDPHILSLLRLSFPSLFKFLAWNSPPLTAEFVVLLPALVEAGTTVEMLHALLDLPCLTAALDLQLRSTQTPSERPLWDVSLRIPGCLEAFRDPQFQGLFRHLLRTKASGSMERLTPLHQLLKPMASCARVTQCAEAVPILLQAFFSTVTQLADGALINQLVLLLLDRSDSLYQAPQYEARVHRVLNSQFLALCKLKPSLVVELSRELLEFVGNVSSICSRASMFTCVVWAIGEYLSVTCDKRCTVEQINKFFEALEALLFEVTQSRPSADLPCCPPQVVTALMTTLTKLASRSQDLIPRVSLFLSKLRTLAQNPATSSVHSEEDAEAIRTRATELLTLLKIPSVAQFVFTPTAGVCQPRYHRDANTALPLALRTVSRLVEKEAGLLPG", "length": 807 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M6YX82-1", "protein_name": "AP-5 complex subunit zeta-1 isoform X1", "gene_name": "ap5z1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYAAATESLIKQAREIKEEELQRFCGRVYKLLHSKDVIGEAVDSLQRLHLIVSATKYARELPSDLLMKLQTLLRSSSCPEQLQFLSSSIIRESFPPSVHSLSSDLSQDSRIFSCVAAVVLAQAGGKEDVMPLFHHLMKSFESRLSDGQIPKHALPILSSMITTYSEILTDDQVNLVSRKLVDWLRYASMQQGASMSSGGFFSAPRTRQPAPLTEVDGVVTGDFFTVLCVGQSYTEDQWMNMYAFSMIKSWLLTYDTEGTTNTESALLKRAQIIQLQHQDDRSEVDSSVMSMVSATSSSSRLLPPKERLREKAFEYCQRLIEQSDRKALKRTDTELQKACIVESVSIMDIICGEDPSYVYRAFPCIKALYGRLNGDFAYARTLLPIAQFYLNHSETAAVDSEAVFCQLFGHCPAEQFNEPMLAFEFVQFCLLNSSVLQDRVANYRQSFPNLLKFLAWNSSGLIAEFVELLPSLVAPDTAIELLHTILDLPCLAAALDLQQRSSCYQASDRTTWDQQGAKVAACLEAFRQPSYRGLFLYILRPEAGTGDTIDRLKELHQILADMAECPRVVQCAQIVPVLLHVYFNTVTEKADEKMMNQLLLVLLERCSLLYNIKTFHVEVQRAFSTHLQALCKHHPPLIVDQSREILEFAGSPTNIYSKEDFYTHVVWVIGEYLSVSYDPRCRVELITSFFECLEAVLFEITQVRQSASPPSFSPRLITVLMTTLAKLATRSQDLIPRASLFLSKMRTFARSAPVTACYSEEDTEEIITRAHELINLLKLPNVAQFVLAPSAGADGPRWHRDTNASLPQAMRTVSGLLHKHSSFLPA", "length": 826 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZI01-1", "protein_name": "Adaptor related protein complex 5 subunit zeta 1", "gene_name": "AP5Z1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGTAAAESLLKQAREVQEDELSRFAARVAAQLQGPEPGPEAADCLQRLHLVLAASKSPRQLDAQLVELLQAVLCSPKCPQQIQLLCAAILREMAPCDGLRLSCERIHDTKLLSLVSSVLLAQGEEKAEVSAVGQRIVKALEGRLPEGQSSRYLLPVLSNVISLSPEALTEEQTNVVSKKMADWLRYASTQQGVAQPSGGFFSNPRTRQPGPVTEVDGAIATDFFTVLSLGQHYTEDQWLNMQTFSMLRKWLLCYGDKKMNTPNSGDKSQTDRSVVSVVSTSSTSSRLLPPKERLREKAFEYCQRLIEQSNRQALKKADGDLQKACLIEAVAIMDIICKQDSSYVYRAASFLKILHGRISGDATYARALLPIAQFFLNHGEMAAVDSDAIYKHLFTDIPAQLFHNSSLAFEFVLFCRDNSQLLTETSSVFRQSFPNLFKFLAWNSPPLIAEFVDILPFLLDAGTAIEIFHLLLDLPCLTAALDVQMRSSSLPSSERAACDPAVKPAACLEAFRSPLYRSAFQYLLRVESVSEDFQERLIPLRQLLGSLASSPRVVQCADTVPVLLELFFSVVSEFADASLINQLVVLVLQRSDQLYEIPAFKDDVHRVLSSQLVMLCKLHPALIVELSKELLEFSGTVSNIQNKEPIFTHVVWAIGEYMSVSYDKRCTVEQINRFFETLEAVLFEVTQVRPQISVPNYAPRAITVLMAALTKLAARSQDLIPRVSLFLSKMRTFVQSPAVTSVYCEEDREEILTRATELMNLLKMPSVAQFVFTPSVDVARTRFQKEVNDTLPSALRIVTRLLEPAPGFVPG", "length": 811 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RI49-1", "protein_name": "Adaptor related protein complex 5 subunit zeta 1", "gene_name": "AP5Z1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFTAGAESLLRQAREIRDEELGRLCSRVCALLGREDWGPDALDALRRLFLIVSATKHGRRLEQPCVELLQAALCSPTCPEQLQLLCAAVLREVSPSRSLSLTCDRVQNTQQLGLVASVLLAQGDRRQVGSVGQCALRVLESRQPEGPGLRHLLPVVSKVTNLAPDALHEEQTNTLNRRLGDWLRHASVQQGIAHSSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSTGQHFTEDQWLNVQAFSMLRAWLLHGGPGGSSTPDADDRSELEGSTLSVLSAASTASHLLPPQERLREKAFEYCQRLIEQSNRRALRKADSELQKACLVEAVLVLDVLCRQDPSFLYRTLSCLRALHARLCGDPTCVRALLPVAQFFLHHGEAAAVDAEAVYQHLCTRIPAEHFHSPLLALEFVQFCRASLPLFGRHLGVLRSSFPNLFKFLAWSSPPLTAEFVALLPSLVDAGTAVEMLDLLLDLPCLTAALDLQLRSSQAASEKPLWDVSVRAAGCLEAFRDPQYQALFQHLLRAKASGTTERLVPLHQLLQPLAGCARVAQCAEAVPILLQAFFAAVTQFADGTLTSQLALLLLERSDTLYEVPGYQARVHKVLSSQFLALCTRRPSLVVEQAKELLEFVGSLGGPHGGGHMLTSVVWAIGEYLSVSWDRRCTVEQINKFFEALEALLFEVTQSRPSAALPACPPQVITVLMTTLTKLASRSQDLIPRVSLFLSKMRTLAQSPAAGSAHGEEDARAVLTRATELLNLLKMPSVAQFVLTPSAEVSEPRYHRDTNTALPLALSTVSRLVERDAGLLPG", "length": 807 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O43299-1", "protein_name": "AP-5 complex subunit zeta-1", "gene_name": "AP5Z1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSAGAESLLHQAREIQDEELKKFCSRICKLLQAEDLGPDTLDSLQRLFLIISATKYSRRLEKTCVDLLQATLGLPACPEQLQVLCAAILREMSPSDSLSLAWDHTQNSRQLSLVASVLLAQGDRNEEVRAVGQGVLRALESRQPEGPSLRHLLPVMAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHSVLSSQFLALCTLKPSLVVELARDLLEFLGSVNGLCSRASLVTSVVWAIGEYLSVTYDRRCTVEQINKFFEALEALLFEVTQCRPSAALPRCPPQVVTVLMTTLTKLASRSQDLIPRASLLLSKMRTLAHSPATSSTHSEEGAEAIRTRATELLTLLKMPSVAQFVLTPSTEVCSPRYHRDANTALPLALRTVSRLVEREAGLMPG", "length": 807 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3U829-1", "protein_name": "AP-5 complex subunit zeta-1", "gene_name": "Ap5z1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSAGAESLLHQAREIQDEELRRFCSRVTKLLQEAPGPATVDALQRLFLIVSATKYPRRLEKMCVDLLQTTLCLPASPEQLQVLCAAILREMSPFNDLALSCDHTPNTRQLSLVASVLLAQGDRKGEIRCVSQRIFKILENRQPEGPSVRPLLPILSKVIGLAPGILMEDQTNLLSKRLVDWLRYASIQQGLPYSGGFFSTPRTRQPGPITEVDGAVASDFFTVLSTGQHFTEDQWVNMQAFSMLRKWLLHSGPEDPCSPDADDKSELEGSTLSVLSAASTASRLLPPRERLREVAFEYCQRLLEQSNRRALRKGDSDLQKACLVEAVSVLDVLCRQDPSFLYRTLSCLKALHRRLGEDPGSERALVPLAQFFLNHGEAAAMDAEAVYGQLLRGLPSERFHSPTLAFEVIHFCTHNLALFDSHFLSLLRLSFPSLFKFLAWNSPPLTAEFVVLLPALVDAGTAVEMLHALLDLPCLTAALDLQLRSTQTPSERLLWDISLRVPSCLEAFQDPQFQGLFRHLLRTKASGSTERLTPLHQVLKPMASCARVTQCAEAVPVLLQAFFSAVTQTADGALINQLALLLLERSDSLYPVPQYEARVHGVLSSQLLVLCKLKPSLVVELSRELLEFVGSVSSIHSRASVFTCVVWAIGEYLSVTWDKRCTAEQINKFFEALEALLFEVTQSRPLADLPCCPPEVVTALMTTLTKLASRSQDLIPRVSLFLSKMRTLAQNPATSSVHSEEGAESIRTRASELLTLLKMPSVAQFVFTPPAGVCQPRYHRDTNVALPLALRTVSRLVEKEAGLLPG", "length": 807 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54B09-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MQTNVSGAVNIEELLNKIENVFGKNQKSLSINSTFIEKFTTLLLDPNTPYKIKLFTLSTLSKFSKNEHQILYKNFKTFDPKTLPLILSLLLSTGTDSQIYISSIPFLVQTISSQDPITRSASMPSLAISARYHSNSLTNLHIKPIETQLIQFLSHASLISDQKQSSIGFFSKIGNTSATPVTELDGSVSIEFFTVLNNSTNYTEDQTFNIYSFSILYTWLINLYKINKQQSLTNTDQQIEQLDQQIEQQLELIEKQQDQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHRTLNQSFQNTIVSYCLRLIDQSKLKPIDGSGNNNSNLNGGNSGNSNSSGGGSMIYNKPIQQQSATAIALGIDESGGDDLSVMALLESIRILDYLCLLDSNLIAKIFPTVQKAYQLHLPSSKNTNATSGHILLALLQFFVNHSHTLVYDPEPLFKVYFQTYLPRTYMNSFVSFETINFCLKNKKTLLKNSNVFNLYFPPIFKCLAWFPNSLSGEFSELLPSFISPNSFIEVFHLLLDLPLLTLSMESVLVEQRKYASMGIEHNDVGVDTAWSEYRVLYNYLLRNESGVNINFWSTTTLPLLQQFCKKNPVTPRSIGSCELVPLLLDIYFEVLLEYGSLNTFVTLLPVIFERMEQIFPYEPYQKRIRENLMSHLLSIFKKHSTLIQSEKELILSVISEARMTYKDIVTLSLSFIIGEYCSPYVCPTITSDVYSDYHEALELITYEKINTIKMESLSNSSQSSLQQSSLIMKQQQQQQQKQQQHQQEQSSSSNNNNNDIKNIENNENDNDIEKLNNDKKNNDNENDQNQNFINNYNLNYNLNINILNNINNFNLNNIIDNDDFEKLQEQYNINIMLNLISSLTKIASRWPDATSRVVLCLMKIIGYQQYFDPQVIQRANESISLLKYPSFAAALYSCQQPQNDSFHSTISSTTIGQTIQDCNSSLSFLLNDTLNYKSKNTIHPFILK", "length": 975 }, "evidence": [ { "id": "A0AAA9TCS9", "url": "https://omabrowser.org/oma/group/A0AAA9TCS9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "AP-5 adaptor complex", "id": "GO:0044599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044599", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCS9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" }, { "id": "PF14764", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14764" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP-5 complex subunit zeta-1 ARM repeats", "eco_id": "ECO_0000259", "start_pos": 356, "end_pos": 473, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TCS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" }, { "id": "PF25154", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25154" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP-5 complex subunit zeta-1 C-terminal TPR", "eco_id": "ECO_0000259", "start_pos": 486, "end_pos": 833, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TCS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS9" }, { "id": "PF25153", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25153" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP-5 complex subunit zeta-1 N-terminal TPR", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 315, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCI2-1", "uniprot_ac": "A0AAA9TCI2", "uniprot_id": "A0AAA9TCI2_BOVIN", "mass": { "chemical_mass": 66176.0, "monoisotopic_mass": 66176.0 }, "refseq": {}, "gene_names": [ { "name": "HMGXB4", "type": "recommended", "evidence": [ { "id": "A0AAA9TCI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ] } ], "protein_names": [ { "name": "High mobility group protein 2-like 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TCI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Negatively regulates Wnt/beta-catenin signaling during development.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M556", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M556#function" }, { "database": "UniProtKB", "id": "ARBA00058884", "url": "https://www.uniprot.org/uniprotkb/ARBA00058884#function" }, { "database": "UniProtKB", "id": "A0AAA9SPX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX2#function" }, { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HMGXB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2", "locus": { "chromosome": "5", "start_pos": 73543335, "end_pos": 73508738, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010533", "url": "https://www.ensembl.org/id/ENSBTAG00000010533" } ] } } ], "crossref": [ { "id": "A0AAA9TCI2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010533", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010533", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21982", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21982", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505539", "url": "https://www.ncbi.nlm.nih.gov/gene/505539", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HKSVERS", "url": "https://omabrowser.org/oma/group/HKSVERS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46584", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46584", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46584:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46584:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13775", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13775", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M556", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M556", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M556-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M556-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMD8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVLGALCSNNLCDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHRKKRKHSSDDYYYGDISSLEPSQKKKKKSSPQSADTAMDLLKAITSPLATGAKPSKKIGEKSSSSSSHSESKKEHHRKKVSGSSGELSLEDGSSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQGTVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDPRSSPGPEGCGSEASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPPAAVAGEVPVPPVPAPSLPYAGAPTPPPPLPSLHTDGHNEKKKKREEKDRERDRGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLVWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSMGVLSPQKKSPPTAMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 605, "header": "tr|A0AAA9TCI2-1|A0AAA9TCI2_BOVIN Isoform 1 of High mobility group protein 2-like 1 OS=Bos taurus OX=9913 GN=HMGXB4 PE=4 SV=1 CANONICAL=A0AAA9TCI2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M556-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2/entry#A0A3Q1M556-1", "sequence": { "sequence": "MAYDDSVKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHRKKRKHSSDDYYYGDISSLEPSQKKKKKSSPQSADTAMDLLKAITSPLATGAKPSKKIGEKSSSSSSHSESKKEHHRKKVSGSSGELSLEDGSSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQGTVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDPRSSPGPEGCGSEASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPPAAVAGEVPVPPVPAPSLPYAGAPTPPPPLPSLHTDGHNEKKKKREEKDRERDRGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLVWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSMGVLSPQKKSPPTAMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETESLEGLMLKPKLQFFDHRMRRARLTGKDPDAGKD", "length": 580, "header": "tr|A0A3Q1M556-1|A0AAA9TCI2_BOVIN Computationally mapped isoform of High mobility group protein 2-like 1 OS=Bos taurus OX=9913 GN=HMGXB4 PE=4 SV=2 CANONICAL=A0AAA9TCI2-1" }, "locus": { "chromosome": "5", "start_pos": 73538230, "end_pos": 73513837, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069504.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069504.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064997.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064997.2" } ] } }, { "isoform_ac": "A0AAA9SPX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2/entry#A0AAA9SPX2-1", "sequence": { "sequence": "MAYDDSVKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHRKKRKHSSDDYYYGDISSLEPSQKKKKKSSPQSADTAMDLLKAITSPLATGAKPSKKIGEKSSSSSSHSESKKEHHRKKVSGSSGELSLEDGSSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQGTVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDPRSSPGPEGCGSEASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPPAAVAGEVPVPPVPAPSLPYAGAPTPPPPLPSLHTDGHNEKKKKREEKDRERDRGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLVWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSMGVLSPQKKSPPTAMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 602, "header": "tr|A0AAA9SPX2-1|A0AAA9TCI2_BOVIN Computationally mapped isoform of High mobility group protein 2-like 1 OS=Bos taurus OX=9913 GN=HMGXB4 PE=4 SV=1 CANONICAL=A0AAA9TCI2-1" }, "locus": { "chromosome": "5", "start_pos": 73542408, "end_pos": 73513837, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106210.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106210.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087420.1" } ] } }, { "isoform_ac": "A0AAA9TCI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2/entry#A0AAA9TCI2-1", "sequence": { "sequence": "MVVLGALCSNNLCDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHRKKRKHSSDDYYYGDISSLEPSQKKKKKSSPQSADTAMDLLKAITSPLATGAKPSKKIGEKSSSSSSHSESKKEHHRKKVSGSSGELSLEDGSSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQGTVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDPRSSPGPEGCGSEASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPPAAVAGEVPVPPVPAPSLPYAGAPTPPPPLPSLHTDGHNEKKKKREEKDRERDRGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLVWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSMGVLSPQKKSPPTAMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 605, "header": "tr|A0AAA9TCI2-1|A0AAA9TCI2_BOVIN Isoform 1 of High mobility group protein 2-like 1 OS=Bos taurus OX=9913 GN=HMGXB4 PE=4 SV=1 CANONICAL=A0AAA9TCI2-1" }, "locus": { "chromosome": "5", "start_pos": 73542408, "end_pos": 73509597, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123027.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123027.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096377.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096377.1" } ] } }, { "isoform_ac": "A0AAF6DMD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2/entry#A0AAF6DMD8-1", "sequence": { "sequence": "MAYDDSVKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHRKKRKHSSDDYYYGDISSLEPSQKKKKKSSPQSADTAMDLLKAITSPLATGAKPSKKIGEKSSSSSSHSESKKEHHRKKVSGSSGELSLEDGSSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQGTVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDPRSSPGPEGCGSEASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPPAAVAGEVPVPPVPAPSLPYAGAPTPPPPLPSLHTDGHNEKKKKREEKDRERDRGEKVWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSMGVLSPQKKSPPTAMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 553, "header": "tr|A0AAF6DMD8-1|A0AAF6DMD8_BOVIN Computationally mapped isoform of HMG-box containing 4 OS=Bos taurus OX=9913 GN=HMGXB4 PE=4 SV=1 CANONICAL=A0AAA9TCI2-1" }, "locus": { "chromosome": "5", "start_pos": 73542408, "end_pos": 73513837, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013925.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013925.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013925.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013925.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 377, "start_aa": "Thr", "end_pos": 377, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr377", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B9A3-1", "protein_name": "High mobility group protein 2-like 1", "gene_name": "HMGXB4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAYDDSVKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHKKKRKHSSDDFYYGDISSLESSQKKKKKSSPQSADTAMDLLKAITSPLATSTKPSKKTGEKSSSSSSHSESKKEHHRKKVSGGSGDLSLEDGGSHRSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSLDEESFQYPSQQATVKKSSKKSARDEQGALLLGHELQSFLKTARKKHRSSSDPRSSPGPEGCGPDASQFPESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSSGLPATAVGEVPAPPAPPPSLPYTGAAAPPLPLPGLQADGHSEKKKKREEKDKDRERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKMKASAAGVLSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 601 }, "evidence": [ { "id": "A0AAA9TCI2", "url": "https://omabrowser.org/oma/group/A0AAA9TCI2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LC40-1", "protein_name": "High mobility group protein 2-like 1", "gene_name": "Hmgxb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTLRHEITPVKLIVLPASSTPVNAQTEGGADKALLCSSQPLDYLEFPPGRLLLHSDFTLQEGFPCLFLRPGPVDGKEPGHSDTAHSQRPCRTTMAYDDSMKKEDCFDGDHSFEDIGLAAGRSQREKKRSYKDFLREEEEVAAQVRSSSKKKSKDSDLFFLGTDTHKKKRKHSPDDFYYGDISTLESSQKKKKKSSPQSPDTAMDLLKAITSPLAAGAKSSKKAGEKSCSSSSHSESRKEHHKKKGNGSTGEPSLDDSNAHKPKRMKPLYVNTETLTLREPDGLKMRLILSPKEKGSSSVEEEAFQYPAQQASLKKPSKKLAREEQGALLLGHELQSLLKTARKKHKSSSDSHSSPGPEGCGSDGSQLPEPHSANLDITGLDPILVESESSSAGELEAGELVIDDSYREIKKKKKSKKSKKKKDKDRHKEKRHSRTKRSSTREHGTAREHMLVSSPASSIPTLPLPALHTDGHGEKKKKKEEKDRERERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSAEGTMKVRASSVGILSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 688 }, "evidence": [ { "id": "A0AAA9TCI2", "url": "https://omabrowser.org/oma/group/A0AAA9TCI2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UGU5-1", "protein_name": "HMG domain-containing protein 4", "gene_name": "HMGXB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYDDSVKKEDCFDGDHTFEDIGLAAGRSQREKKRSYKDFLREEEEIAAQVRNSSKKKLKDSELYFLGTDTHKKKRKHSSDDYYYGDISSLESSQKKKKKSSPQSTDTAMDLLKAITSPLAAGSKPSKKTGEKSSGSSSHSESKKEHHRKKVSGSSGELPLEDGGSHKSKKMKPLYVNTETLTLREPDGLKMKLILSPKEKGSSSVDEESFQYPSQQATVKKSSKKSARDEQGALLLGHELQSFLKTARKKHKSSSDAHSSPGPEGCGSDASQFAESHSANLDLSGLEPILVESDSSSGGELEAGELVIDDSYREIKKKKKSKKSKKKKDKEKHKEKRHSKSKRSLGLSAVPVGEVTVTSGPPPSIPYAGAAAPPLPLPGLHTDGHSEKKKKKEEKDKERERGEKPKKKNMSAYQVFCKEYRVTIVADHPGIDFGELSKKLAEVWKQLPEKDKLIWKQKAQYLQHKQNKAEATTVKRKASSSEGSMKVKASSVGVLSPQKKSPPTTMLLPASPAKAPETEPIDVAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSIICALGPLACLTTQLPELNGCPKQVLSNTLDNIAYIMPGL", "length": 601 }, "evidence": [ { "id": "A0AAA9TCI2", "url": "https://omabrowser.org/oma/group/A0AAA9TCI2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "pmid": "" }, { "name": "NURF complex", "id": "GO:0016589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI2" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 411, "end_pos": 479, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 377 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 414, "end_pos": 416 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9Y0-1", "uniprot_ac": "A0AAA9T9Y0", "uniprot_id": "A0AAA9T9Y0_BOVIN", "mass": { "chemical_mass": 283646.0, "monoisotopic_mass": 283646.0 }, "refseq": { "ac": "XP_059738600", "name": "probable JmjC domain-containing histone demethylation protein 2C isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738600" }, "gene_names": [ { "name": "JMJD1C", "type": "recommended", "evidence": [ { "id": "A0AAA9T9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ] }, { "name": "JMJD1C", "type": "synonym", "evidence": [ { "id": "XP_059738600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738600" } ] } ], "protein_names": [ { "name": "Jumonji domain-containing protein 1C", "type": "recommended", "evidence": [ { "id": "A0AAA9T9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0/entry#names_and_taxonomy" } ] }, { "name": "probable JmjC domain-containing histone demethylation protein 2C isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059738600", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738600" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "JMJD1C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0", "locus": { "chromosome": "28", "start_pos": 19314567, "end_pos": 19584150, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001573", "url": "https://www.ensembl.org/id/ENSBTAG00000001573" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001573", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001573", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781067", "url": "https://www.ncbi.nlm.nih.gov/gene/781067", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M831", "url": "https://www.orthodb.org/?gene=A0A3Q1M831", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N685", "url": "https://www.orthodb.org/?gene=F1N685", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12549", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12549", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12549:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12549:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22987", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22987", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22988", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22988", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059738600", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738600", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M831", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M831", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M831-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M831-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N685", "url": "https://www.uniprot.org/uniprotkb/F1N685", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N685-1", "url": "https://www.uniprot.org/uniprotkb/F1N685-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVETRPELVGKRFLCLALGEEARLERGESGRCWRGWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWARRINPSQTQGSKSKQIQWPALTFKPLVEKSVPSSITAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLQEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNSNTVHGHYTRAQANSPRPAMNSQTAVPKQNSHQQQRNIRPNKRKGSDSSIPDEEKMKEEKYDYIARGENPKGKKQVMNKRRKAEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIINNSSEQKPENELKNKNTSKINGEEGKSQNNEKAEETLIDSQHPWDQIQEDKKHEETEKQKSVDFQRQEKMIIHSSEQATLSDHNSSDLLLQERNTEKTHTMELLPKEKFVSRPPTPKCVIDITNDTNTEKVAQETSSSTFGLQTLQKMDPNVSDSKHSIANTKYLETGNQDSDQNWVSDVVKVDLTQSNVRNASSGNENLSMEKEKNQYVSYLSSLSAVSVTEDKLHKRSPPPETIKSKLNTSVDAPKTKSNPSPEVVKPKVNHSPDSVKSKATYANSQAAGERRPANKIEHELSRCSFHPVPTRGSTLETTKSPLIIDKNEHFTVYRDPALIGSDTGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHSVHHPHLLPTVLPGVPTASLLGGHPRLETAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSKWVHPENAVNAEPSLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKIAAHSSPPLTKCLVDHHKEELERKAFIEPLRSVASTSAKNDLDLNRSQTGKDGHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGLECDRDNYSRVASSSSSPKSHVIKQDKDIETDLYKMKHSVPHSLPQSNYFTTLSNSVVNEPPRSYPSKEISNIYTEKQSNTLATAANPQTLTSFISSLSKPPPLIKHQPESEGLVGKVPEHLSHQFASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDTQASFKSSSEQSLTEMWKSNNNLSKEKAEWRVEKSSGKSQAAMASVIVRPPSSTKLDSVPAVQLASKERVSERSSLGANQTDCLKPAEAGESGRVILPSVNSDSAHIKSEKNFQAVSQGSVPSSVTSAVSTVCNTKTDTFTSAATAPGVSSWGGSEIIYSLSNTILASKSLECTSSKSVSHSVAQTQECTVSITAPVTPASSKTGSAVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNVSETEPNAAKSQTSSASHLLDSTVVCSTINKADSVGNGQASQTSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGSSVSEIIKPCSVNLIASTSNDLQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEMEEDLKPNGILSRSAKEKSKLKLQSNNNSAGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDELDIETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNIQVGNFSPMNGVSQVLQNVLNHSNKISLCMPESQQQSTPQKPESNGSSSPGSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKEFALEKQIKEEREQDDPDSPNSRTSPPVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTPSGKSGRTMPNILDDIIASVVENKIPPNKASKINVKSEFKEEPKESRKSAMDENSKLYSDIPHSWICEKHILWLKDYKNTNNWKLFKECWKYGQPAVVSGVHKKMNISLWKADSISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKTKSGETVVLKLKDCPSGEDFKTMMPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHVEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTLVQFLGDAIVLPAGALHQVQNFHSCIQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKIHEDEVEAMEEN", "length": 2535, "header": "tr|A0AAA9T9Y0-1|A0AAA9T9Y0_BOVIN Isoform 1 of Jumonji domain-containing protein 1C OS=Bos taurus OX=9913 GN=JMJD1C PE=3 SV=1 CANONICAL=A0AAA9T9Y0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M831-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0/entry#A0A3Q1M831-1", "sequence": { "sequence": "MAVETRPELVGKRFLCLALGEEARLERGESGRCWRGWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWARRINPSQTQGSKSKQIQWPALTFKPLVEKSVPSSITAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLQEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNSNTVHGHYTRAQANSPRPAMNSQTAVPKQNSHQQQRNIRPNKRKGSDSSIPDEEKMKEEKYDYIARGENPKGKKQVMNKRRKAEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIINNSSEQKPENELKNKNTSKINGEEGKSQNNEKAEETLIDSQHPWDQIQEDKKHEETEKQKSVDFQRQEKMIIHSSEQATLSDHNSSDLLLQERNTEKTHTMELLPKEKFVSRPPTPKCVIDITNDTNTEKVAQETSSSTFGLQTLQKMDPNVSDSKHSIANTKYLETGNQDSDQNWVSDVVKVDLTQSNVRNASSGNENLSMEKEKNQYVSYLSSLSAVSVTEDKLHKRSPPPETIKSKLNTSVDAPKTKSNPSPEVVKPKVNHSPDSVKSKATYANSQAAGERRPANKIEHELSRCSFHPVPTRGSTLETTKSPLIIDKNEHFTVYRDPALIGSDTGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHSVHHPHLLPTVLPGVPTASLLGGHPRLETAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSKWVHPENAVNAEPSLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKIAAHSSPPLTKCLVDHHKEELERKAFIEPLRSVASTSAKNDLDLNRSQTGKDGHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGLECDRDNYSRVASSSSSPKSHVIKQDKDIETDLYKMKHSVPHSLPQSNYFTTLSNSVVNEPPRSYPSKEISNIYTEKQSNTLATAANPQTLTSFISSLSKPPPLIKHQPESEGLVGKVPEHLSHQFASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDTQASFKSSSEQSLTEMWKSNNNLSKEKAEWRVEKSSGKSQAAMASVIVRPPSSTKLDSVPAVQLASKERVSERSSLGANQTDCLKPAEAGESGRVILPSVNSDSAHIKSEKNFQAVSQGSVPSSVTSAVSTVCNTKTDTFTSAATAPGVSSWGGSEIIYSLSNTILASKSLECTSSKSVSHSVAQTQECTVSITAPVTPASSKTGSAVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNVSETEPNAAKSQTSSASHLLDSTVVCSTINKADSVGNGQASQTSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGSSVSEIIKPCSVNLIASTSNDLQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEMEEDLKPNGILSRSAKEKSKLKLQSNNNSAGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDELDIETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNIQVGNFSPMNGVSQVLQNVLNHSNKISLCMPESQQQSTPQKPESNGSSSPGSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKEFALEKQIKEEREQDDPDSPNSRTSPPVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTPSGKSGRTMPNILDDIIASVVENKIPPNKASKINVKSEFKEEPKESRKSAMDENSKLYSDIPHSWICEKHILWLKDYKNTNNWKLFKECWKYGQPAVVSGVHKKMNISLWKADSISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKTKSGETVVLKLKDCPSGEDFKTMMPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHVEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTLVQFLGDAIVLPAGALHQALISCPYFAAL", "length": 2473, "header": "tr|A0A3Q1M831-1|A0AAA9T9Y0_BOVIN Computationally mapped isoform of Jumonji domain-containing protein 1C OS=Bos taurus OX=9913 GN=JMJD1C PE=3 SV=2 CANONICAL=A0AAA9T9Y0-1" }, "locus": { "chromosome": "28", "start_pos": 19583951, "end_pos": 19317931, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079122.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079122.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070036.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070036.2" } ] } }, { "isoform_ac": "A0AAA9T9Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0/entry#A0AAA9T9Y0-1", "sequence": { "sequence": "MAVETRPELVGKRFLCLALGEEARLERGESGRCWRGWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWARRINPSQTQGSKSKQIQWPALTFKPLVEKSVPSSITAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLQEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNSNTVHGHYTRAQANSPRPAMNSQTAVPKQNSHQQQRNIRPNKRKGSDSSIPDEEKMKEEKYDYIARGENPKGKKQVMNKRRKAEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIINNSSEQKPENELKNKNTSKINGEEGKSQNNEKAEETLIDSQHPWDQIQEDKKHEETEKQKSVDFQRQEKMIIHSSEQATLSDHNSSDLLLQERNTEKTHTMELLPKEKFVSRPPTPKCVIDITNDTNTEKVAQETSSSTFGLQTLQKMDPNVSDSKHSIANTKYLETGNQDSDQNWVSDVVKVDLTQSNVRNASSGNENLSMEKEKNQYVSYLSSLSAVSVTEDKLHKRSPPPETIKSKLNTSVDAPKTKSNPSPEVVKPKVNHSPDSVKSKATYANSQAAGERRPANKIEHELSRCSFHPVPTRGSTLETTKSPLIIDKNEHFTVYRDPALIGSDTGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHSVHHPHLLPTVLPGVPTASLLGGHPRLETAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSKWVHPENAVNAEPSLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKIAAHSSPPLTKCLVDHHKEELERKAFIEPLRSVASTSAKNDLDLNRSQTGKDGHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGLECDRDNYSRVASSSSSPKSHVIKQDKDIETDLYKMKHSVPHSLPQSNYFTTLSNSVVNEPPRSYPSKEISNIYTEKQSNTLATAANPQTLTSFISSLSKPPPLIKHQPESEGLVGKVPEHLSHQFASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDTQASFKSSSEQSLTEMWKSNNNLSKEKAEWRVEKSSGKSQAAMASVIVRPPSSTKLDSVPAVQLASKERVSERSSLGANQTDCLKPAEAGESGRVILPSVNSDSAHIKSEKNFQAVSQGSVPSSVTSAVSTVCNTKTDTFTSAATAPGVSSWGGSEIIYSLSNTILASKSLECTSSKSVSHSVAQTQECTVSITAPVTPASSKTGSAVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNVSETEPNAAKSQTSSASHLLDSTVVCSTINKADSVGNGQASQTSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGSSVSEIIKPCSVNLIASTSNDLQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEMEEDLKPNGILSRSAKEKSKLKLQSNNNSAGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDELDIETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNIQVGNFSPMNGVSQVLQNVLNHSNKISLCMPESQQQSTPQKPESNGSSSPGSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKEFALEKQIKEEREQDDPDSPNSRTSPPVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTPSGKSGRTMPNILDDIIASVVENKIPPNKASKINVKSEFKEEPKESRKSAMDENSKLYSDIPHSWICEKHILWLKDYKNTNNWKLFKECWKYGQPAVVSGVHKKMNISLWKADSISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKTKSGETVVLKLKDCPSGEDFKTMMPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHVEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTLVQFLGDAIVLPAGALHQVQNFHSCIQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKIHEDEVEAMEEN", "length": 2535, "header": "tr|A0AAA9T9Y0-1|A0AAA9T9Y0_BOVIN Isoform 1 of Jumonji domain-containing protein 1C OS=Bos taurus OX=9913 GN=JMJD1C PE=3 SV=1 CANONICAL=A0AAA9T9Y0-1" }, "locus": { "chromosome": "28", "start_pos": 19583951, "end_pos": 19315165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112140.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112140.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095513.1" } ] } }, { "isoform_ac": "F1N685-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0/entry#F1N685-1", "sequence": { "sequence": "MAVETRPELVGKRFLCLALGEEARLERGESGRCWRGWRAGVIRAVSHRDSRNPDLAVYVEFDDLEWDKREWVKVYEDFSTFLVEYHLIWARRINPSQTQGSKSKQIQWPALTFKPLVEKSVPSSITAVEFLVDKQLDFLTEDSAFQPYQDDIDSLNPVLRDNPQLQEEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQGHYTRAQANSPRPAMNSQTAVPKQNSHQQQRNIRPNKRKGSDSSIPDEEKMKEEKYDYIARGENPKGKKQVMNKRRKAEEDEKKLNMKRLRTDNVSDFSESSDSENSNKRIINNSSEQKPENELKNKNTSKINGEEGKSQNNEKAEETLIDSQHPWDQIQEDKKHEETEKQKSVDFQRQEKMIIHSSEQATLSDHNSSDLLLQERNTEKTHTMELLPKEKFVSRPPTPKCVIDITNDTNTEKVAQETSSSTFGLQTLQKMDPNVSDSKHSIANTKYLETGNQDSDQNWVSDVVKVDLTQSNVRNASSGNENLSMEKEKNQYVSYLSSLSAVSVTEDKLHKRSPPPETIKSKLNTSVDAPKTKSNPSPEVVKPKVNHSPDSVKSKATYANSQAAGERRPANKIEHELSRCSFHPVPTRGSTLETTKSPLIIDKNEHFTVYRDPALIGSDTGANHISPFLSQHPFPLHSSSHRTCLNPGTHHPALTPAPHLLAGSSSQTPLPTINTHPLTSGPHHSVHHPHLLPTVLPGVPTASLLGGHPRLETAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSKWVHPENAVNAEPSLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPLKIAAHSSPPLTKCLVDHHKEELERKAFIEPLRSVASTSAKNDLDLNRSQTGKDGHLHRHFVDPVLNQLQRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGLECDRDNYSRVASSSSSPKSHVIKQDKDIETDLYKMKHSVPHSLPQSNYFTTLSNSVVNEPPRSYPSKEISNIYTEKQSNTLATAANPQTLTSFISSLSKPPPLIKHQPESEGLVGKVPEHLSHQFASHSVTTFRNDCRSPTHLTVSSTNTLRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDTQASFKSSSEQSLTEMWKSNNNLSKEKAEWRVEKSSGKSQAAMASVIVRPPSSTKLDSVPAVQLASKERVSERSSLGANQTDCLKPAEAGESGRVILPSVNSDSAHIKSEKNFQAVSQGSVPSSVTSAVSTVCNTKTDTFTSAATAPGVSSWGGSEIIYSLSNTILASKSLECTSSKSVSHSVAQTQECTVSITAPVTPASSKTGSAVQPSSGFSGTTDFIHLKKHKAALAAAQYKSSNVSETEPNAAKSQTSSASHLLDSTVVCSTINKADSVGNGQASQTSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGSSVSEIIKPCSVNLIASTSNDLQNSVDSKIIVDKYVKDDKVNRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEMEEDLKPNGILSRSAKEKSKLKLQSNNNSAGIPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEEPTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDELDIETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNIHWVCQKCGFVVCLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMPTQIIPGSVLTDLLDAMHTLREKYGIKSHCHCTNKQNIQVGNFSPMNGVSQVLQNVLNHSNKISLCMPESQQQSTPQKPESNGSSSPGSDVSTDSKLTPPESQSPLHWLADLAEQKAREEKKENKEFALEKQIKEEREQDDPDSPNSRTSPPVSQNNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTPSGKSGRTMPNILDDIIASVVENKIPPNKASKINVKSEFKEEPKESRKSAMDENSKLYSDIPHSWICEKHILWLKDYKNTNNWKLFKECWKYGQPAVVSGVHKKMNISLWKADSISLDFGDHQADLLNCKDSIISNANVKEFWDGFEEVSKRQKTKSGETVVLKLKDCPSGEDFKTMMPARYEDLLKSLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHVEVSDVVNILVYVGIAKGNGILSKAGILKKFEEEDLDDILRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNKKLRQRLLEEYGVKTCTLVQFLGDAIVLPAGALHQVQNFHSCIQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKIHEDEVEAMEEN", "length": 2487, "header": "tr|F1N685-1|F1N685_BOVIN Computationally mapped isoform of Jumonji domain-containing protein 1C OS=Bos taurus OX=9913 GN=JMJD1C PE=3 SV=3 CANONICAL=A0AAA9T9Y0-1" }, "locus": { "chromosome": "28", "start_pos": 19583951, "end_pos": 19315165, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002067.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002067.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002067.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002067.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1451, "start_aa": "Thr", "end_pos": 1451, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1451", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2091, "start_aa": "Thr", "end_pos": 2091, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2091", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" }, { "name": "dioxygenase activity", "id": "GO:0051213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051213", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Y0" } ], "pmid": "" }, { "name": "histone H3K9 demethylase activity", "id": "GO:0032454", "url": 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"categories": [ "Protein" ] }, { "id": "A0AAA9TBH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDI6", "url": "https://www.uniprot.org/uniprotkb/F1MDI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDI6-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLPNSIFHESLNVSASVSSSLKLILVSTCVCVLGCPTLCDPMNYSPPASPVHGVFQVSAFPQEKDKKMMKFQEPVSFKDVAVVFTEEELGLLDSAQRRLYQEVMLENFQNLLSVGNQPFKPELIFQLEREERLMMESQRGGCSGTKSPHNMESIQEVGLSCFSPKDLSTWQSWQRGAGRLTGCQDSMRNFQENISQLQKQGDSPCQVWAGIPIQISEDENCVLTHIGDGSNDIKNQEFPSWRAHHSWRKMYLTESRNYQCRCQQVSKENDFCKSDSISWISHHGDNLGVHRTGKNSSCHDCGEDVMKVSLLNHIQTGQKPYPGNEFRKAFSDDSSSEVHQQLDLEGKPCTYSACEKDCSYRSVLHIHQSVCRGDHCIFENSHLQSHQKGHAKEKPFKCEYSESINQCSSHNTYQLIPRGETSDRYSVYEKGFSHSLDLSSIVRVYIEEESHESEENGNAFNENSCLQAHQKIHTEEKRYTDMECEKGFICNSDLNIQHRVHMEEVPYNSEACANGFSLASHFQNLQIVHTREQPYKRYTCGNSFSQSSYLQAHQKIHIGEKPYKVCGNGFNWNSKLKDHQRVHTGEKPYKCSACGKGFSHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEACGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECEKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHTGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHQRVHTGGKPYKCAVCTKGFSESSRLQAHQRVHTEGRPYKCEQCGKGFSGFSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSGDKFYTSEEYSKGYPSSENPYRSEVL", "length": 975, "header": "tr|A0AAA9TBH2-1|A0AAA9TBH2_BOVIN Isoform 1 of Zinc finger protein 112 OS=Bos taurus OX=9913 GN=ZNF112 PE=3 SV=1 CANONICAL=A0AAA9TBH2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MC21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2/entry#A0A3Q1MC21-1", "sequence": { "sequence": "MVSAFPQEKDKKMMKFQEPVSFKDVAVVFTEEELGLLDSAQRRLYQEVMLENFQNLLSVGNQPFKPELIFQLEREERLMMESQRGGCSGTKSPHNMESIQEVGLSCFSPKDLSTWQSWQRGAGRLTGCQDSMRNFQENISQLQKQGDSPCQVWAGIPIQISEDENCVLTHIGDGSNDIKNQEFPSWRAHHSWRKMYLTESRNYQCRCQQVSKENDFCKSDSISWISHHGDNLGVHRTGKNSSCHDCGEDVMKVSLLNHIQTGQKPYPGNEFRKAFSDDSSSEVHQQLDLEGKPCTYSACEKDCSYRSVLHIHQSVCRGDHCIFENSHLQSHQKGHAKEKPFKCEYSESINQCSSHNTYQLIPRGETSDRYSVYEKGFSHSLDLSSIVRVYIEEESHESEENGNAFNENSCLQAHQKIHTEEKRYTDMECEKGFICNSDLNIQHRVHMEEVPYNSEACANGFSLASHFQNLQIVHTREQPYKRYTCGNSFSQSSYLQAHQKIHIGEKPYKVCGNGFNWNSKLKDHQRVHTGEKPYKCSACGKGFSHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEACGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECEKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHTGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHQRVHTGGKPYKCAVCTKGFSESSRLQAHQRVHTEGRPYKCEQCGKGFSGFSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSGDKFYTSEEYSKGYPSSENPYRSEVL", "length": 919, "header": "tr|A0A3Q1MC21-1|A0AAA9TBH2_BOVIN Computationally mapped isoform of Zinc finger protein 112 OS=Bos taurus OX=9913 GN=ZNF112 PE=3 SV=2 CANONICAL=A0AAA9TBH2-1" }, "locus": { "chromosome": "18", "start_pos": 52273858, "end_pos": 52244077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079660.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079660.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067870.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067870.2" } ] } }, { "isoform_ac": "A0AAA9T5B1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2/entry#A0AAA9T5B1-1", "sequence": { "sequence": "MNYSPPASPVHGVFQVSAFPQEKDKKMMKFQEPVSFKDVAVVFTEEELGLLDSAQRRLYQEVMLENFQNLLSVGNQPFKPELIFQLEREERLMMESQRGGCSGTKSPHNMESIQEVGLSCFSPKDLSTWQSWQRGAGRLTGCQDSMRNFQENISQLQKQGDSPCQVWAGIPIQISEDENCVLTHIGDGSNDIKNQEFPSWRAHHSWRKMYLTESRNYQCRCQQVSKENDFCKSDSISWISHHGDNLGVHRTGKNSSCHDCGEDVMKVSLLNHIQTGQKPYPGNEFRKAFSDDSSSEVHQQLDLEGKPCTYSACEKDCSYRSVLHIHQSVCRGDHCIFENSHLQSHQKGHAKEKPFKCEYSESINQCSSHNTYQLIPRGETSDRYSVYEKGFSHSLDLSSIVRVYIEEESHESEENGNAFNENSCLQAHQKIHTEEKRYTDMECEKGFICNSDLNIQHRVHMEEVPYNSEACANGFSLASHFQNLQIVHTREQPYKRYTCGNSFSQSSYLQAHQKIHIGEKPYKVCGNGFNWNSKLKDHQRVHTGEKPYKCSACGKGFSHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEACGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECEKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHTGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHQRVHTGGKPYKCAVCTKGFSESSRLQAHQRVHTEGRPYKCEQCGKGFSGFSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSGDKFYTSEEYSKGYPSSENPYRSEVL", "length": 933, "header": "tr|A0AAA9T5B1-1|A0AAA9TBH2_BOVIN Computationally mapped isoform of Zinc finger protein 112 OS=Bos taurus OX=9913 GN=ZNF112 PE=3 SV=1 CANONICAL=A0AAA9TBH2-1" }, "locus": { "chromosome": "18", "start_pos": 52269849, "end_pos": 52244077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108520.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108520.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093960.1" } ] } }, { "isoform_ac": "A0AAA9TBH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2/entry#A0AAA9TBH2-1", "sequence": { "sequence": "MTLPNSIFHESLNVSASVSSSLKLILVSTCVCVLGCPTLCDPMNYSPPASPVHGVFQVSAFPQEKDKKMMKFQEPVSFKDVAVVFTEEELGLLDSAQRRLYQEVMLENFQNLLSVGNQPFKPELIFQLEREERLMMESQRGGCSGTKSPHNMESIQEVGLSCFSPKDLSTWQSWQRGAGRLTGCQDSMRNFQENISQLQKQGDSPCQVWAGIPIQISEDENCVLTHIGDGSNDIKNQEFPSWRAHHSWRKMYLTESRNYQCRCQQVSKENDFCKSDSISWISHHGDNLGVHRTGKNSSCHDCGEDVMKVSLLNHIQTGQKPYPGNEFRKAFSDDSSSEVHQQLDLEGKPCTYSACEKDCSYRSVLHIHQSVCRGDHCIFENSHLQSHQKGHAKEKPFKCEYSESINQCSSHNTYQLIPRGETSDRYSVYEKGFSHSLDLSSIVRVYIEEESHESEENGNAFNENSCLQAHQKIHTEEKRYTDMECEKGFICNSDLNIQHRVHMEEVPYNSEACANGFSLASHFQNLQIVHTREQPYKRYTCGNSFSQSSYLQAHQKIHIGEKPYKVCGNGFNWNSKLKDHQRVHTGEKPYKCSACGKGFSHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEACGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECEKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHTGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHQRVHTGGKPYKCAVCTKGFSESSRLQAHQRVHTEGRPYKCEQCGKGFSGFSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSGDKFYTSEEYSKGYPSSENPYRSEVL", "length": 975, "header": "tr|A0AAA9TBH2-1|A0AAA9TBH2_BOVIN Isoform 1 of Zinc finger protein 112 OS=Bos taurus OX=9913 GN=ZNF112 PE=3 SV=1 CANONICAL=A0AAA9TBH2-1" }, "locus": { "chromosome": "18", "start_pos": 52269975, "end_pos": 52244077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134585.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134585.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096072.1" } ] } }, { "isoform_ac": "F1MDI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2/entry#F1MDI6-1", "sequence": { "sequence": "MLLSGILGSVVREVSVGRVTSGSGTRGRGLRSSRKGLCLSPGKGQEDDEVPGNQPFKPELIFQLEREERLMMESQRGGCSGTKSPHNMESIQEVGLSCFSPKDLSTWQSWQRGAGRLTGCQDSMRNFQENISQLQKQGDSPCQVWAGIPIQISEDENCVLTHIGDGSNDIKNQEFPSWRAHHSWRKMYLTESRNYQCRCQQVSKENDFCKSDSISWISHHGDNLGVHRTGKNSSCHDCGEDVMKVSLLNHIQTGQKPYPGNEFRKAFSDDSSSEVHQQLDLEGKPCTYSACEKDCSYRSVLHIHQSVCRGDHCIFENSHLQSHQKGHAKEKPFKCEYSESINQCSSHNTYQLIPRGETSDRYSVYEKGFSHSLDLSSIVRVYIEEESHESEENGNAFNENSCLQAHQKIHTEEKRYTDMECEKGFICNSDLNIQHRVHMEEVPYNSEACANGFSLASHFQNLQIVHTREQPYKRYTCGNSFSQSSYLQAHQKIHIGEKPYKVCGNGFNWNSKLKDHQRVHTGEKPYKCSACGKGFSHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEACGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECEKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHTGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHQRVHTGGKPYKCAVCTKGFSESSRLQAHQRVHTEGRPYKCEQCGKGFSGFSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSGDKFYTSEEYSKGYPSSENPYRSEVL", "length": 911, "header": "tr|F1MDI6-1|A0AAA9TBH2_BOVIN Computationally mapped isoform of Zinc finger protein 112 OS=Bos taurus OX=9913 GN=ZNF112 PE=3 SV=2 CANONICAL=A0AAA9TBH2-1" }, "locus": { "chromosome": "18", "start_pos": 52270355, "end_pos": 52244077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055043.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055043.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050759.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050759.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q0VAW7-1", "protein_name": "Zinc finger protein 112", "gene_name": "Znf112", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKLQEMVTFRDVAVVFSEEELGLLDAAQWKLYREVMLENFRMLLSVAHQPFKPGLIAQLENGEQLWMVEAEAHAGGLSGRRNGHAVENAEDVEVNSLCPEDLSFCQTWPWGACTLPSGQEFIKRCQGSNGESQSQEASPRLVWAGMPMQISEDGNYGLPPAHEDSASMKNQEFPPPRSQQSQGEPYLGRPCVTCQWKGQQTSIRNHFCRYGSVCWSPYHSDNEELYSKGKSYGFHDDRGKTVKVLLLNQDFIELGPEPCPRTKNREAWGHDNDHSSHTHQQCHSRGKPCTRSLSGEGCGDRSALHGHPGLEAGDEGADGSPPLQSSPRVCMEQVPRECSGNVHYGSPLNTCGCAHPGNTSQTCSIPKQAVGSPVHCNSTFRAHPREEPNNYEENRNVFNQSSCLQVSRKIGAEEKLCQGVECRKNFTHCSSLNIPHRVPVEETLCNPDCGNHFSLPPHFQDFPGVRAREQPHNRLCRTGFSQTLCLQGHQKLHIREKPSHREGGSGCNWSSTPKDPQKQKLHKCNACGKGFSHRSVLDIHHRIHTGEKPYKCEECGKGFSRSAYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPYKCEECGKGFSWSFNLQIHQRVHTGEKPYKCGECGKGFSKASTLLAHERVHTGEKPYQCHECGKNFSQKSYLQSHQSVHSGERPHICEVCGKGFSQRAYLQGHLRVHTRVKPYKCEVCGKGFSQGSRLEAHQRVHTGRKPFKCETCTKGFSESSRLQAHQRIHEEGRPYKCDQCGKGFSGYSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYTCDACGKGFRWSSGLLIHQRAHSSDTFYRSGECGSSYPPENLCRNEGL", "length": 879 }, "evidence": [ { "id": "A0AAA9TBH2", "url": "https://omabrowser.org/oma/group/A0AAA9TBH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJU3-1", "protein_name": "Zinc finger protein 112", "gene_name": "ZNF112", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTKFQEMVTFKDVAVVFTEEELGLLDSVQRKLYRDVMLENFRNLLLVAHQPFKPDLISQLEREEKLLMVETETPRDGCSGRKNQQKMESIQEVTVSYFSPKELSSRQTWQQSAGGLIRCQDFLKVFQGKNSQLQEQGNSLGQVWAGIPVQISEDKNYIFTHIGNGSNYIKSQGYPSWRAHHSWRKMYLKESHNYQCRCQQISMKNHFCKCDSVSWLSHHNDKLEVHRKENYSCHDCGEDIMKVSLLNQESIQTEEKPYPCTGYRKAFSNDSSSEVHQQFHLEGKPYTYSSCGKGCNYSSLLHIHQNIEREDDIENSHLKSYQRVHTEEKPCKCGEYGENFNHCSPLNTYELIHTGEMSYRHNIYEKAFSHSLDLNSIFRVHTRDEPHEYEENENVFNQSSCLQVHQKIHTEEKLYTDIEYGKSFICSSNLDIQHRVHMEENSYNSEECGNGFSLASHFQDLQIVHTKEQPYKRYVCSNSFSHNLYLQGHPKIHIGEKPRKEHGNGFNWSSKLKDHQRVHTGQKPYKCNICGKGFNHRSVLNVHQRVHTGEKPYKCEECDKGFSRSSYLQAHQRVHTGEKPYKCEECGKGFSRNSYLQGHQRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTGEKPFKCEECGKGFSWSFNLQIHQRVHTGEKPYKCEECGKGFSKASTLLAHQRVHTGEKPYQCDECGKSFSQRSYLQSHQSVHSGERPYICEVCGKGFSQRAYLQGHQRVHTRVKPYKCEMCGKGFSQSSRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQRVHVEGRPYKCEQCGKGFSGYSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLIHQRVHSSDKFYKSEDYGKDYPSSENLHRNEDSVLF", "length": 913 }, "evidence": [ { "id": "A0AAA9TBH2", "url": "https://omabrowser.org/oma/group/A0AAA9TBH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "histone H3K4 methyltransferase activity", "id": "GO:0042800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042800", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "histone H3K36 methyltransferase activity", "id": "GO:0046975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046975", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "recombination hotspot binding", "id": "GO:0010844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010844", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" }, { "name": "positive regulation of reciprocal meiotic recombination", "id": "GO:0010845", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010845", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 452, "end_pos": 479, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBH2" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 76, "end_pos": 147, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDU7-1", "uniprot_ac": "A0AAA9TDU7", "uniprot_id": "A0AAA9TDU7_BOVIN", "mass": { "chemical_mass": 61996.0, "monoisotopic_mass": 61996.0 }, "refseq": { "ac": "XP_024832659", "name": "synaptotagmin-14 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832659" }, "gene_names": [ { "name": "SYT14", "type": "recommended", "evidence": [ { "id": "A0AAA9TDU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7" } ] }, { "name": "SYT14", "type": "synonym", "evidence": [ { "id": "XP_024832659", "database": "RefSeq", "url": 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"MAIEGGERTCGVHELICIRKVSPEAVGFLSAVGVFIILMLLLFLYINKKFCFENVGGFPDLGSGYSARKNSQDKIYNSYLDKDEPGSSSESEDEALGKYHEALSRTHNSRLPLAESRQKSYTWETRQKYSPLSAEYDGYSSEASVDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDVSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGIHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSGSVSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWVSLGLNSSGEEELNHWTEMKESKGQQVCRWHALLES", "length": 555, "header": "tr|A0AAA9TDU7-1|A0AAA9TDU7_BOVIN Isoform 1 of Synaptotagmin 14 OS=Bos taurus OX=9913 GN=SYT14 PE=3 SV=1 CANONICAL=A0AAA9TDU7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MH60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7/entry#A0A3Q1MH60-1", "sequence": { "sequence": 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"ENSBTAP00000094943.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094943.1" } ] } }, { "isoform_ac": "A0AAA9TQQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7/entry#A0AAA9TQQ2-1", "sequence": { "sequence": "MAFFKSFQQNLPSVSSLVDTISNAVEDLTTAVGEVSYAFTDSVAEQVTSMINGFCPEEESSAAPEAADTSKQESTTISEVSQNTNCQKAPFNLENQADRINSYNTSVSQKQDQRMSEGGGVKHINNRQQMPSQYQETDNALKGDSSLKGHVSDGRVSVSRQNASAGSPWQELQSTDRCRKNGLEISSDGKHDLKEVRYQEMKENYLKKAETHIKSKGYKGHNYSGNECSPKDILESSRHMIQKSIKKEDLYPAASTDSKEQCQGKIKEQINPTKFYKGKADIKTKKNEAISAKKETAKSKDEKYFKIIPEKDNSYLDKDEPGSSSESEDEALGKYHEALSRTHNSRLPLAESRQKSYTWETRQKYSPLSAEYDGYSSEASVDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDVSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGIHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSGSVSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWVSLGLNSSGEEELNHWTEMKESKGQQVCRWHALLES", "length": 791, "header": "tr|A0AAA9TQQ2-1|A0AAA9TQQ2_BOVIN Computationally mapped isoform of Synaptotagmin 14 OS=Bos taurus OX=9913 GN=SYT14 PE=3 SV=1 CANONICAL=A0AAA9TDU7-1" }, "locus": { "chromosome": "16", "start_pos": 73310019, "end_pos": 73169610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100914.1" } ] } }, { "isoform_ac": "G3N3K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7/entry#G3N3K6-1", "sequence": { "sequence": "MAIEGGERTCGVHELICIRKDNSYLDKDEPGSSSESEDEALGKYHEALSRTHNSRLPLAESRQKSYTWETRQKYSPLSAEYDGYSSEASVDEGNCIQRMRRTPPLDELQPPPYQDDSGSPHLSCTPSEIGDSKCEFSHCSNSPRCSYNKCPSEGSTGHEIESFHNKGYEEDVPSDSTAVLSPEDVSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQEQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGIHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSGSVSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWVSLGLNSSGEEELNHWTEMKESKGQQVCRWHALLES", "length": 500, "header": "tr|G3N3K6-1|G3N3K6_BOVIN Computationally mapped isoform of Synaptotagmin 14 OS=Bos taurus OX=9913 GN=SYT14 PE=3 SV=3 CANONICAL=A0AAA9TDU7-1" }, "locus": { "chromosome": "16", "start_pos": 73371217, "end_pos": 73169610, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063087.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063087.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056509.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056509.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787880", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDU7", "database": "UniProtKB", "url": 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"chemical_mass": 75131.0, "monoisotopic_mass": 75131.0 }, "refseq": {}, "gene_names": [ { "name": "CFAP99", "type": "recommended", "evidence": [ { "id": "A0AAA9TD24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24" } ] } ], "protein_names": [ { "name": "Cilia and flagella associated protein 99", "type": "synonym", "evidence": [ { "id": "A0AAA9TD24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CFAP99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24", "locus": { "chromosome": "6", "start_pos": 116225495, "end_pos": 116259601, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054376", "url": "https://www.ensembl.org/id/ENSBTAG00000054376" } ] } } ], "crossref": [ { "id": "A0AAA9TD24", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TD24", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR039341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR34649", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34649", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34649:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34649:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27956", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27956", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TD24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTYYGKCIEMVMKHLDRFQPEKDSPEQFLEATAASLQTLSPQKQAFIMEILSGCLEYHKLLTIVVDAFYVRDGRLCLRADYSLFEVICYLATFQLEELGFQLFRDVVRSQPVHKVCQFLRFLFNPLNLGSWIKDEWSLVYETSHVKENWIDPLMRWQPEIQELIDQLQGELTSQLSPPKSKAKVTEPKELSLTTPRPRAIPVPEPVPQVAKTRPVPRSTYQPPKEQRLLEMTKRYNRWKAEELLLQANFEELRCAVPRSRGEPQLQDSKKKPRLRLPPRILKAQKLTFYTPNDNAPVKLNTAAILREGALYQRQVEKELQRVDRLVDGAGDFSEFLEWQRRMQAKDREEQLAAGEVRRLRGKLSHEEAVLARQQVAREKRRTAELKKEETAELMQRCAERRLQEEKSTKELVEQVMETQKNVRVAQTELRKGRRRIAQEVTEENRELLQRSAEAAKEEQRRRCTLVSQLRALEFQPTRRGKLVDLTQIPGHGLEGEMSVVELRERLALLKETRRLQEEERRDQIIQGKRAKSQELRDTVEQVALCRAAMGRSAALRWEEKKARWAAAGAPSQDERVLELQRRIQERAERRARAAPGHVPAPRAVRPKQRAQLEAQRRLELERSRERWLRAQQPGCGPARRLGAA", "length": 644, "header": "tr|A0AAA9TD24-1|A0AAA9TD24_BOVIN Isoform 1 of Cilia and flagella associated protein 99 OS=Bos taurus OX=9913 GN=CFAP99 PE=4 SV=2 CANONICAL=A0AAA9TD24-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TD24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD24/entry#A0AAA9TD24-1", "sequence": { "sequence": "MTYYGKCIEMVMKHLDRFQPEKDSPEQFLEATAASLQTLSPQKQAFIMEILSGCLEYHKLLTIVVDAFYVRDGRLCLRADYSLFEVICYLATFQLEELGFQLFRDVVRSQPVHKVCQFLRFLFNPLNLGSWIKDEWSLVYETSHVKENWIDPLMRWQPEIQELIDQLQGELTSQLSPPKSKAKVTEPKELSLTTPRPRAIPVPEPVPQVAKTRPVPRSTYQPPKEQRLLEMTKRYNRWKAEELLLQANFEELRCAVPRSRGEPQLQDSKKKPRLRLPPRILKAQKLTFYTPNDNAPVKLNTAAILREGALYQRQVEKELQRVDRLVDGAGDFSEFLEWQRRMQAKDREEQLAAGEVRRLRGKLSHEEAVLARQQVAREKRRTAELKKEETAELMQRCAERRLQEEKSTKELVEQVMETQKNVRVAQTELRKGRRRIAQEVTEENRELLQRSAEAAKEEQRRRCTLVSQLRALEFQPTRRGKLVDLTQIPGHGLEGEMSVVELRERLALLKETRRLQEEERRDQIIQGKRAKSQELRDTVEQVALCRAAMGRSAALRWEEKKARWAAAGAPSQDERVLELQRRIQERAERRARAAPGHVPAPRAVRPKQRAQLEAQRRLELERSRERWLRAQQPGCGPARRLGAA", "length": 644, "header": "tr|A0AAA9TD24-1|A0AAA9TD24_BOVIN Isoform 1 of Cilia and flagella associated protein 99 OS=Bos taurus OX=9913 GN=CFAP99 PE=4 SV=2 CANONICAL=A0AAA9TD24-1" }, "locus": { "chromosome": "6", "start_pos": 116259296, "end_pos": 116227251, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115030.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115030.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096552.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096552.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAK2-1", "uniprot_ac": "A0AAA9TAK2", "uniprot_id": "A0AAA9TAK2_BOVIN", "mass": { "chemical_mass": 33052.0, "monoisotopic_mass": 33052.0 }, "refseq": { "ac": "XP_024852596", "name": "sperm acrosome membrane-associated protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852596" }, "gene_names": [ { "name": "SPACA1", "type": "recommended", "evidence": [ { "id": "A0AAA9TAK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2" } ] }, { "name": "SPACA1", "type": "synonym", "evidence": [ { "id": "XP_024852596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852596" } ] } ], "protein_names": [ { "name": "Sperm acrosome associated 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TAK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2/entry#names_and_taxonomy" } ] }, { "name": "sperm acrosome membrane-associated protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024852596", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852596" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPACA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2", "locus": { "chromosome": "9", "start_pos": 61867833, "end_pos": 61898389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019469", "url": "https://www.ensembl.org/id/ENSBTAG00000019469" } ] } } ], "crossref": [ { "id": "A0AAA9TAK2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019469", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019469", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13783", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13783", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614884", "url": "https://www.ncbi.nlm.nih.gov/gene/614884", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FIIVNWA", "url": "https://omabrowser.org/oma/group/FIIVNWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR47223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47223:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47223:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27947", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27947", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024852596", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852596", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHA2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN30", "url": "https://www.uniprot.org/uniprotkb/F1MN30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN30-1", "url": "https://www.uniprot.org/uniprotkb/F1MN30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETENEPQAEAEDDSEVSNKTIVKEVEFGMCTVTCGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWTAVKDFWGAKASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 299, "header": "tr|A0AAA9TAK2-1|A0AAA9TAK2_BOVIN Isoform 1 of Sperm acrosome associated 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=4 SV=1 CANONICAL=A0AAA9TAK2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MHA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2/entry#A0A3Q1MHA2-1", "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETENEPQAEAEDDSEGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFKTNVLASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 266, "header": "tr|A0A3Q1MHA2-1|A0AAA9TAK2_BOVIN Computationally mapped isoform of Sperm acrosome associated 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=4 SV=1 CANONICAL=A0AAA9TAK2-1" }, "locus": { "chromosome": "9", "start_pos": 61898190, "end_pos": 61867922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080848.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080848.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070024.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070024.1" } ] } }, { "isoform_ac": "A0AAA9TAK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2/entry#A0AAA9TAK2-1", "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETENEPQAEAEDDSEVSNKTIVKEVEFGMCTVTCGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWTAVKDFWGAKASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 299, "header": "tr|A0AAA9TAK2-1|A0AAA9TAK2_BOVIN Isoform 1 of Sperm acrosome associated 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=4 SV=1 CANONICAL=A0AAA9TAK2-1" }, "locus": { "chromosome": "9", "start_pos": 61898190, "end_pos": 61867922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093912.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093912.1" } ] } }, { "isoform_ac": "F1MN30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2/entry#F1MN30-1", "sequence": { "sequence": "MKSRGAGCSARLLLTVGWLLLAGLQSTCGINVTAIQDPSLAREGEGEPEGDEEPENDSETENEPQAEAEDDSEGIGIREVILTSGCPGGESKCIVRVEECRGPVDCGWGRPISESLEHVRLACVHTSPENRFKYIWRLLRPDQQAIILANDSAILEVHRDTHPKAFECETLDNNEIVASIRFTIYTTTELQMKRASRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWTAVKDFWGAKASTTEIQSELSSMRYKDSTSLDQSPTDIPGHEDDALSEWNE", "length": 280, "header": "tr|F1MN30-1|A0AAA9TAK2_BOVIN Computationally mapped isoform of Sperm acrosome associated 1 OS=Bos taurus OX=9913 GN=SPACA1 PE=4 SV=1 CANONICAL=A0AAA9TAK2-1" }, "locus": { "chromosome": "9", "start_pos": 61898190, "end_pos": 61867922, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025934.4", "url": "https://www.ensembl.org/id/ENSBTAT00000025934.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025934.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025934.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3Z9F9-1", "protein_name": "Sperm acrosome associated 1", "gene_name": "Spaca1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVARHGELRSAAPSGHCSKRLSSRAGAAIVRWAAVRPRSMRARGAGCPAWLLALGWLILVGLQASQASNVTSSIQDPGMAREGESSSENEPEEEIENEGEVVETDTTIEAEEEVQNKTVVKEVEFGMCTVTCGVGIREVILTNGCPGGESKCVVRVEECRGPVDCGWGRPISESLESARLSCIHISPENRFKYIWKLLKPDQQPVILINDSAVLEVPRELHPMAFECDTLDNNEMVASVKFTVYTTTELQMKRSTRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWAAVKSFWGAKASTTEIQSEMSSMRYKDSTSLDQSPTDIPVHEDDALSEWNE", "length": 339 }, "evidence": [ { "id": "A0AAA9TAK2", "url": "https://omabrowser.org/oma/group/A0AAA9TAK2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D5K8A9-1", "protein_name": "Sperm acrosome membrane-associated protein 1", "gene_name": "SPACA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPGGAGCSAGLLLTVGWLLLAGLQSTCGINVTAVQDPSLVSEGENEGEEEAENDSEVENEPQAEAEQDVSNKTVVKEVEFGMCTVTCGVGIREVLLTNGCPGGESKCIVRVEECRGPVDCGWGKPISENLESVRLSCVHTSPVNRFKYVWRLLRPNQQAVILANDSAILEVQRETHPMAFQCETLDNNEIVATVKFTVYTTAELQMKRSSRPDTDAVLVFVLTIGVIICIFVIFVLIFIIVNWATVKDFWASKASTTEIQSELSSMKYKDSTSLDQSPTEIPGHEDDALSEWNE", "length": 295 }, "evidence": [ { "id": "A0AAA9TAK2", "url": "https://omabrowser.org/oma/group/A0AAA9TAK2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9DA48-1", "protein_name": "Sperm acrosome membrane-associated protein 1", "gene_name": "Spaca1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRARGAGCPAGLLAVGWLILVGLQASQASNVTSSGGGVQEPAVAREGESESESESEEEAENEGEVPESETTAEADAEEEVQNRTIVKEVEFGMCTVTCGVGIREVILTNGCPGGESKCVVRVEECRGPVDCGWGKPISENLDSARLSCVHISPENRFKYVWKLLKPDQQPVILTNDSAVLEITREIRPLAFECDTLDNNEMVASVKFTVYTTNELQMRRSSRPDTDAVLVFVLTIGVIICIFVIFVLIFIIINWAAVKSFWGSKTSATEIQSELSSMRYKDSTSLDQSPTDIPVHEDDALSEWNE", "length": 305 }, "evidence": [ { "id": "A0AAA9TAK2", "url": "https://omabrowser.org/oma/group/A0AAA9TAK2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HBV2-1", "protein_name": "Sperm acrosome membrane-associated protein 1", "gene_name": "SPACA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPRGTGCSAGLLMTVGWLLLAGLQSARGTNVTAAVQDAGLAHEGEGEEETENNDSETAENYAPPETEDVSNRNVVKEVEFGMCTVTCGIGVREVILTNGCPGGESKCVVRVEECRGPTDCGWGKPISESLESVRLACIHTSPLNRFKYMWKLLRQDQQSIILVNDSAILEVRKESHPLAFECDTLDNNEIVATIKFTVYTSSELQMRRSSLPATDAALIFVLTIGVIICVFIIFLLIFIIINWAAVKAFWGAKASTPEVQSEQSSVRYKDSTSLDQLPTEMPGEDDALSEWNE", "length": 294 }, "evidence": [ { "id": "A0AAA9TAK2", "url": "https://omabrowser.org/oma/group/A0AAA9TAK2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "acrosomal membrane", "id": "GO:0002080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002080", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCY4-1", "uniprot_ac": "A0AAA9TCY4", "uniprot_id": "A0AAA9TCY4_BOVIN", "mass": { "chemical_mass": 51673.0, "monoisotopic_mass": 51673.0 }, "refseq": {}, "gene_names": [ { "name": "TOX2", "type": "recommended", "evidence": [ { "id": "A0AAA9TCY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ] } ], "protein_names": [ { "name": "TOX high mobility group box family member 2", "type": "synonym", "evidence": [ { "id": "A0AAA9TCY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TOX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4", "locus": { "chromosome": "13", "start_pos": 72567818, "end_pos": 72414389, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016741", "url": "https://www.ensembl.org/id/ENSBTAG00000016741" } ] } } ], "crossref": [ { "id": "A0AAA9TCY4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016741", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016741", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519845", "url": "https://www.ncbi.nlm.nih.gov/gene/519845", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MK10", "url": "https://www.orthodb.org/?gene=A0A3Q1MK10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPI6", "url": "https://www.orthodb.org/?gene=F1MPI6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45781", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45781", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45781:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45781:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MK10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPI6", "url": "https://www.uniprot.org/uniprotkb/F1MPI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPI6-1", "url": "https://www.uniprot.org/uniprotkb/F1MPI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQNCTEAVAGAFSRCLGFCGMRLGLLLLTRRWCIAGVFQQKFDGESAYVGMSDGNPELLSTSQTFNSQNESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKMSGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPSLSASPPPPPSFPLSTPLHQQLPLPPHAQGTLLSPPVSMSPAPQPPVLPAPMALQVQLAVSPSPPGPQDFPHISEFPSSSGPRSPGPSNPTSSGDWDSSYPSTECGVSTCSLLPRDKSLYLT", "length": 488, "header": "tr|A0AAA9TCY4-1|A0AAA9TCY4_BOVIN Isoform 1 of TOX high mobility group box family member 2 OS=Bos taurus OX=9913 GN=TOX2 PE=4 SV=1 CANONICAL=A0AAA9TCY4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MK10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4/entry#A0A3Q1MK10-1", "sequence": { "sequence": "MDVRLYPSAPAVGARPGAEPTGLAPLDYYHCGKFDGESAYVGMSDGNPELLSTSQTFNSQNESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKMSGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKDFPHISEFPSSSGPRSPGPSNPTSSGDWDSSYPSTECGVSTCRLCRGRPPPAASPKNLLEPPAP", "length": 384, "header": "tr|A0A3Q1MK10-1|A0AAA9TCY4_BOVIN Computationally mapped isoform of TOX high mobility group box family member 2 OS=Bos taurus OX=9913 GN=TOX2 PE=4 SV=1 CANONICAL=A0AAA9TCY4-1" }, "locus": { "chromosome": "13", "start_pos": 72567041, "end_pos": 72414436, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000066571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071760.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071760.1" } ] } }, { "isoform_ac": "A0AAA9TCY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4/entry#A0AAA9TCY4-1", "sequence": { "sequence": "MQQNCTEAVAGAFSRCLGFCGMRLGLLLLTRRWCIAGVFQQKFDGESAYVGMSDGNPELLSTSQTFNSQNESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKMSGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQSSPDQGETKSAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPSLSASPPPPPSFPLSTPLHQQLPLPPHAQGTLLSPPVSMSPAPQPPVLPAPMALQVQLAVSPSPPGPQDFPHISEFPSSSGPRSPGPSNPTSSGDWDSSYPSTECGVSTCSLLPRDKSLYLT", "length": 488, "header": "tr|A0AAA9TCY4-1|A0AAA9TCY4_BOVIN Isoform 1 of TOX high mobility group box family member 2 OS=Bos taurus OX=9913 GN=TOX2 PE=4 SV=1 CANONICAL=A0AAA9TCY4-1" }, "locus": { "chromosome": "13", "start_pos": 72566814, "end_pos": 72445071, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131440.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131440.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094604.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094604.1" } ] } }, { "isoform_ac": "A0AAA9TGM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4/entry#A0AAA9TGM8-1", "sequence": { "sequence": "MDVRLYPSAPAVGARPGAEPTGLAPLDYYHCGKFDGESAYVGMSDGNPELLSTSQTFNSQNESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKMSGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPSLSASPPPPPSFPLSTPLHQQLPLPPHAQGTLLSPPVSMSPAPQPPVLPAPMALQVQLAVSPSPPGPQDFPHISEFPSSSGPRSPGPSNPTSSGDWDSSYPSTECGVSTCSLLPRDKSLYLT", "length": 506, "header": "tr|A0AAA9TGM8-1|A0AAA9TGM8_BOVIN Computationally mapped isoform of TOX high mobility group box family member 2 OS=Bos taurus OX=9913 GN=TOX2 PE=4 SV=1 CANONICAL=A0AAA9TCY4-1" }, "locus": { "chromosome": "13", "start_pos": 72566814, "end_pos": 72414436, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094242.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094242.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096204.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096204.1" } ] } }, { "isoform_ac": "F1MPI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4/entry#F1MPI6-1", "sequence": { "sequence": "MDVRLYPSAPAVGARPGAEPTGLAPLDYYHCGKTFNSQNESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSGIAHSSPSPPGSKSATPSPSSSTQEEESEAHFKMSGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPSLSASPPPPPSFPLSTPLHQQLPLPPHAQGTLLSPPVSMSPAPQPPVLPAPMALQVQLAVSPSPPGPQDFPHISEFPSSSGPRSPGPSNPTSSGDWDSSYPSTECGVSTCRLCRGRPPPAASPKNLLEPPAP", "length": 494, "header": "tr|F1MPI6-1|A0AAA9TCY4_BOVIN Computationally mapped isoform of TOX high mobility group box family member 2 OS=Bos taurus OX=9913 GN=TOX2 PE=4 SV=4 CANONICAL=A0AAA9TCY4-1" }, "locus": { "chromosome": "13", "start_pos": 72567041, "end_pos": 72414436, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022257.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022257.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022257.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022257.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 209, "start_aa": "Thr", "end_pos": 209, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr209", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 82, "start_aa": "Thr", "end_pos": 82, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr82", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCY4" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 255, "end_pos": 302, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 82, 209 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDC3-1", "uniprot_ac": "A0AAA9TDC3", "uniprot_id": "A0AAA9TDC3_BOVIN", "mass": { "chemical_mass": 96698.0, "monoisotopic_mass": 96698.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM63B", "type": "recommended", "evidence": [ { "id": "A0AAA9TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ] } ], "protein_names": [ { "name": "Transmembrane protein 63B", "type": "synonym", "evidence": [ { "id": "A0AAA9TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM63B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3", "locus": { "chromosome": "23", "start_pos": 17684043, "end_pos": 17658530, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032680", "url": "https://www.ensembl.org/id/ENSBTAG00000032680" } ] } } ], "crossref": [ { "id": "A0AAA9TDC3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDC3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032680", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032680", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534891", "url": "https://www.ncbi.nlm.nih.gov/gene/534891", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534891", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534891", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSCKKEN", "url": "https://omabrowser.org/oma/group/CSCKKEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJM3", "url": "https://www.orthodb.org/?gene=A0A3Q1NJM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MY22", "url": "https://www.orthodb.org/?gene=F1MY22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13018:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13018:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13967", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13967", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14703", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14703", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NJM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJM3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY22", "url": "https://www.uniprot.org/uniprotkb/F1MY22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MY22-1", "url": "https://www.uniprot.org/uniprotkb/F1MY22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPFLLATLGTMALNSSSPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADSVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKDNVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRSSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLLFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVVCLCHVCFGHFKYLSAHNYKIEHTETDSVDPRSNGRPPNAAAVPKSAKYIAQVLQDSEVDGDGGPGSSGDEPPSSSSQDEELLMQPDGLTDTDFQSCEDSLIENEIRQEGRRRREGVGFAQGYQPGRDLGNVLLSISVNWAPA", "length": 852, "header": "tr|A0AAA9TDC3-1|A0AAA9TDC3_BOVIN Isoform 1 of Transmembrane protein 63B OS=Bos taurus OX=9913 GN=TMEM63B PE=3 SV=1 CANONICAL=A0AAA9TDC3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NJM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3/entry#A0A3Q1NJM3-1", "sequence": { "sequence": "MLPFLLATLGTMALNSSSPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADSVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKDNVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRSSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLLFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVVCLCHVCFGHFKYLSAHNYKIEHTETDSVDPRSNGRPPNAAAVPKSAKYIAQVLQDSEVDGDGGPGSSGDEPPSSSSQDEELLMQPDGLTDTDFQSCEDSLIENEIRQ", "length": 817, "header": "tr|A0A3Q1NJM3-1|A0AAA9TDC3_BOVIN Computationally mapped isoform of Transmembrane protein 63B OS=Bos taurus OX=9913 GN=TMEM63B PE=3 SV=2 CANONICAL=A0AAA9TDC3-1" }, "locus": { "chromosome": "23", "start_pos": 17682523, "end_pos": 17664291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073931.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073931.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072389.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072389.2" } ] } }, { "isoform_ac": "A0AAA9TDC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3/entry#A0AAA9TDC3-1", "sequence": { "sequence": "MLPFLLATLGTMALNSSSPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADSVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKDNVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRSSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLLFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVVCLCHVCFGHFKYLSAHNYKIEHTETDSVDPRSNGRPPNAAAVPKSAKYIAQVLQDSEVDGDGGPGSSGDEPPSSSSQDEELLMQPDGLTDTDFQSCEDSLIENEIRQEGRRRREGVGFAQGYQPGRDLGNVLLSISVNWAPA", "length": 852, "header": "tr|A0AAA9TDC3-1|A0AAA9TDC3_BOVIN Isoform 1 of Transmembrane protein 63B OS=Bos taurus OX=9913 GN=TMEM63B PE=3 SV=1 CANONICAL=A0AAA9TDC3-1" }, "locus": { "chromosome": "23", "start_pos": 17684043, "end_pos": 17664291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109935.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109935.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094863.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094863.1" } ] } }, { "isoform_ac": "F1MY22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3/entry#F1MY22-1", "sequence": { "sequence": "MLPFLLATLGTMALNSSSPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRRRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVAVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKDNVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRSSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLLFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVVCLCHVCFGHFKYLSAHNYKIEHTETDSVDPRSNGRPPNAAAVPKSAKYIAQVLQDSEVDGDGGPGSSGDEPPSSSSQDEELLMQPDGLTDTDFQSCEDSLIENEIRQ", "length": 830, "header": "tr|F1MY22-1|F1MY22_BOVIN Computationally mapped isoform of Transmembrane protein 63B OS=Bos taurus OX=9913 GN=TMEM63B PE=3 SV=1 CANONICAL=A0AAA9TDC3-1" }, "locus": { "chromosome": "23", "start_pos": 17682523, "end_pos": 17664291, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028054.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028054.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028054.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028054.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534891", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534891", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A105-1", "protein_name": "Transmembrane protein 63B", "gene_name": "Tmem63b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPFLLATLGTAALNSSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERERVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPAMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCACRGEPRASSCSEALHISNWTVTYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNIYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSNGRPPTAGAVPKSAKYIAQVLQDSEGDGDGDGAPGSSGDEPPSSSSQDEELLMPPDGLTDTDFQSCEDSLIENEIHQ", "length": 832 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q06538-1", "protein_name": "Calcium permeable stress-gated cation channel 1", "gene_name": "CSC1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTSYIERLKSAASYLDTVPDEHHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQSSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKIDDGNDDDDSESSLIHLVKRIVEGSGDGDNHSAPERTNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEALKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQPYSENYHLLGNEQSGAVTHGENVPSSNNNDEDTILYSQISLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPTAFVTMDSVANAQMAAQAVLDPRVHYFITRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIGFPLVKIKAKTPRQRNELYNPPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGTLAGFEGGWVLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSSIREYERDNSTVNSANEEESYAYPYAVSELEGPMLD", "length": 782 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q3TWI9-1", "protein_name": "Mechanosensitive cation channel TMEM63B", "gene_name": "Tmem63b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPFLLATLGTAALNSSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERERVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPAMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRASSCSEALHISNWTVTYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSNGRPPTAGAVPKSAKYIAQVLQDSEGDGDGDGAPGSSGDEPPSSSSQDEELLMPPDGLTDTDFQSCEDSLIENEIHQ", "length": 832 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54RR3-1", "protein_name": "CSC1/OSCA1-like 7TM region domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNVVENEKEKFNIFGEISNGSTTHSTSTSSSSSDVYLSTGWPTFTTSFITNIVIGSVIMIIFFFLRIIYRNFYNARLIKSNGLNSVLITSPFQWIIYTISYQMESIFESRGIDAYMHLQFLYLCIQILSIIMVFGIGILLPINYTSITEETANVVLNTLDTVTVGTIQPNSKRLWAHTLSIPIFTMVAFYFFQKTNTIYLEKRIRWMSKHNERNYTVLVREMSRSISNADDMREFFSRFFDSKAILSCHIIYKEAKLRSLWRKHKHVQRSLERVLSESDIKGVPPTRAVGWRPGMFGGKTVDSVEYFTKKLEQVDKELRIAQEEASIKKDLSISQDLAWRVSNITASNIKKLTNMTSTAGFITFSRMAFASQAAQCLFSKNIEKFKVTPAPEIKNIKWKNMIVPNRSRFLRRIVSSIIFFVIFCFYTIPVTAISAVSNIQTLSKVPVLNWLLEVVNLDDTLRGFVEGYLPSLALVLFLALLPLFIKIIIHFNKEDTRTQFYHKVFTVYWAFLVTNVFLVVSIAGTVLGILFKMLENLTLKDIATLLGQSLPKQSSFFINYILVQALTSVPMDIVRPIELIAGIIRSSRESSFGQKMKALSHDDPTSLNSIKYARELLIFVITLSYSTLSPLILPFGLLYFLMDFFVSKYNHIYSFCPKYQSGGMIWPLVFNRLCIGLVIYQLTGIGLFVLKTFIPGIVISFLMPFFTLFYWWRNVDKYKKPSSVLSLDICPEEDYFGNEFVKSYEDPVLSIADLEINNNFKNDHNFNHHNLINKV", "length": 776 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6NP91-1", "protein_name": "Mechanosensitive cation channel Tmem63", "gene_name": "Tmem63", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVMSENSNISYCQAVANRTSFFTTAYNGIPETLILNTIFWVLLILLFTVLRHQAGDFGRLALVNSNGSKKRWTEIFYSRAASVVDPQPSTSTQVSPRPSTTSQGVPDSTPLSPIQPEEGLFGWIRVTLKLRKETILLHTGPDAVHYLSFQQHLMAVMALVTIVSLVIILPVNFLNGPKENPYDVNAFGRTTMANLSPDSPWLWVHTIITILYIPLVVLIMRRASGRNAFKKAATRTIMISNISSSDRNKTVVRNYMQELFPDVTIENVSIAYNISRLYVRNAEFERVHEARLYCEHHRNRDTLMVKPEMCSCKKENAYEYYQREERKLSGDVARLRASTMNEPLDIAFITVSTVQEAQNIVTHFTPGTYRQWHLVFAPSPDDLFWENLNVNKSHWYLKFFCVNAVLFLVLFFLSTPAMVVSLLNSRPWVKETEGKISPLVADFLPTLMLWTLSALMPVIVAISDKWMRHYTRSKQNYSIMTKCFGYLLMMIMILPSLGLTSAQALLEWGFLNQTDRWQCIFLPDRGSFYVNYIITAAFIGTALELLRFPELIVYIWSLLKAKSKAETPYIRKAILIEFPFGTHYAWTTLVFTIAIVYSVACPLIMPFAMIYICLKHFVDRHNLYFAYGPSNMISRKGGKIHSTAVTMTKFSVVILVLVMAMICFFRGDNGMARFLLLIISLAITLTLFTFMSPIKRCAATRRPSIVEIAGPAPIYVPDVLKDNGIRTSSVRPSAAAFGGYGSDSVSEYDSSQYSVNSVEA", "length": 760 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9C8G5-1", "protein_name": "Hyperosmolality-gated Ca2+ permeable channel 3.1", "gene_name": "OSCA3.1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEFGSFLVSLGTSFVIFVILMLLFTWLSRKSGNAPIYYPNRILKGLEPWEGTSLTRNPFAWMREALTSSEQDVVNLSGVDTAVHFVFLSTVLGIFACSSLLLLPTLLPLAATDNNIKNTKNATDTTSKGTFSQLDNLSMANITKKSSRLWAFLGAVYWISLVTYFFLWKAYKHVSSLRAQALMSADVKPEQFAILVRDMPAPPDGQTQKEFIDSYFREIYPETFYRSLVATENSKVNKIWEKLEGYKKKLARAEAILAATNNRPTNKTGFCGLVGKQVDSIEYYTELINESVAKLETEQKAVLAEKQQTAAVVFFTTRVAAASAAQSLHCQMVDKWTVTEAPEPRQLLWQNLNIKLFSRIIRQYFIYFFVAVTILFYMIPIAFVSAITTLKNLQRIIPFIKPVVEITAIRTVLESFLPQIALIVFLAMLPKLLLFLSKAEGIPSQSHAIRAASGKYFYFSVFNVFIGVTLAGTLFNTVKDIAKNPKLDMIINLLATSLPKSATFFLTYVALKFFIGYGLELSRIIPLIIFHLKKKYLCKTEAEVKEAWYPGDLSYATRVPGDMLILTITFCYSVIAPLILIFGITYFGLGWLVLRNQALKVYVPSYESYGRMWPHIHQRILAALFLFQVVMFGYLGAKTFFYTALVIPLIITSLIFGYVCRQKFYGGFEHTALEVACRELKQSPDLEEIFRAYIPHSLSSHKPEEHEFKGAMSRYQDFNAIAGV", "length": 724 }, "evidence": [ { "id": "A0AAA9TDC3", "url": "https://omabrowser.org/oma/group/A0AAA9TDC3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "alveolar lamellar body membrane", "id": "GO:0097233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "calcium-activated cation channel activity", "id": "GO:0005227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005227", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "phospholipid scramblase activity", "id": "GO:0017128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "mechanosensitive monoatomic cation channel activity", "id": "GO:0140135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140135", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "osmolarity-sensing monoatomic cation channel activity", "id": "GO:1990760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990760", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "phosphatidylcholine transfer activity", "id": "GO:0120019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120019", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "sphingomyelin transfer activity", "id": "GO:0140338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140338", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "drinking behavior", "id": "GO:0042756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "intestinal stem cell homeostasis", "id": "GO:0036335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" }, { "name": "surfactant secretion", "id": "GO:0160069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160069", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC3" }, { "id": "PF02714", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02714" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CSC1/OSCA1-like 7TM region", "eco_id": "ECO_0000259", "start_pos": 420, "end_pos": 692, "start_aa": "Arg", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TDC3", "database": "UniProtKB", "url": 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"A0AAA9TD30_BOVIN", "mass": { "chemical_mass": 65082.0, "monoisotopic_mass": 65082.0 }, "refseq": { "ac": "XP_005223345", "name": "zinc finger and BTB domain-containing protein 22 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223345" }, "gene_names": [ { "name": "ZBTB22", "type": "recommended", "evidence": [ { "id": "A0AAA9TD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ] }, { "name": "ZBTB22", "type": "synonym", "evidence": [ { "id": "XP_005223345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223345" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 22", "type": "recommended", "evidence": [ { "id": "A0AAA9TD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 297", "type": "synonym", "evidence": [ { "id": "A0AAA9TD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 22 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005223345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223345" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T142", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T142#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0AAA9RS62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS62#function" }, { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30#function" }, { "database": "UniProtKB", "id": "F1MLP0", "url": "https://www.uniprot.org/uniprotkb/F1MLP0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30", "locus": { "chromosome": "23", "start_pos": 7483218, "end_pos": 7486956, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016829", "url": "https://www.ensembl.org/id/ENSBTAG00000016829" } ] } } ], "crossref": [ { "id": "A0AAA9TD30", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TD30", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016829", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016829", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18210", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18210", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538456", "url": "https://www.ncbi.nlm.nih.gov/gene/538456", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538456", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538456", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KPYDCLS", "url": "https://omabrowser.org/oma/group/KPYDCLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLP0", "url": "https://www.orthodb.org/?gene=F1MLP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005223345", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223345", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RS62", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS62-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T142", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T142", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T142-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T142-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLP0", "url": "https://www.uniprot.org/uniprotkb/F1MLP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MLP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASASATTVTTAAATSVTVPGAGVPSGSGGTVAPATVSSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRTGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIVPQKHWVYVKRGGNCPASAPLAPQDPDLEEEEEEEDLVLTCEDDEDEELGGGSGVPARGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPGAGLDDSGGPTPSSYAPAHPPRPLLPLDMQGNQILIFPSSSSSSSSSQPPGNQAEHGAVTLGGTLAGALGGPGGTGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHHLGGGGGGGPGPGGGPSGPALQPKRESPCGGGGSGDEASGATPPSSRCVWSPLSVHKVEMGFSGGGGAN", "length": 634, "header": "tr|A0AAA9TD30-1|A0AAA9TD30_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 22 OS=Bos taurus OX=9913 GN=ZBTB22 PE=3 SV=1 CANONICAL=A0AAA9TD30-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RS62-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#A0AAA9RS62-1", "sequence": { "sequence": "MPEPTCPPPPKKSVQNPSKRPPRPPSSFPCSCGWGGTPSLHTMEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASASATTVTTAAATSVTVPGAGVPSGSGGTVAPATVSSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRTGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIVPQKHWVYVKRGGNCPASAPLAPQDPDLEEEEEEEDLVLTCEDDEDEELGGGSGVPARGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPGAGLDDSGGPTPSSYAPAHPPRPLLPLDMQGNQILIFPSSSSSSSSSQPPGNQAEHGAVTLGGTLAGALGGPGGTGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHHLGGGGGGGPGPGGGPSGPALQPKRESPCGGGGSGDEASGATPPSSRCVWSPLSVHKVEMGFSGGGGAN", "length": 676, "header": "tr|A0AAA9RS62-1|A0AAA9TD30_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 22 OS=Bos taurus OX=9913 GN=ZBTB22 PE=3 SV=1 CANONICAL=A0AAA9TD30-1" }, "locus": { "chromosome": "23", "start_pos": 7486595, "end_pos": 7484226, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092628.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092628.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075262.1" } ] } }, { "isoform_ac": "A0AAA9T142-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#A0AAA9T142-1", "sequence": { "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASASATTVTTAAATSVTVPGAGVPSGSGGTVAPATVSSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRTGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIVPQKHWVYVKRGGNCPASAPLAPQDPDLEEEEEEEDLVLTCEDDEDEELGGGSGVPARGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPGAGLDDSGGPTPSSYAPAHPPRPLLPLDMQGNQILIFPSSSSSSSSSQPPGNQAEHGAVTLGGTLAGALGGPGGTGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHLIKIFIGHFIWLPDNPDVSAWDRAQPERGFPPPHLLAFGGK", "length": 601, "header": "tr|A0AAA9T142-1|A0AAA9TD30_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 22 OS=Bos taurus OX=9913 GN=ZBTB22 PE=3 SV=1 CANONICAL=A0AAA9TD30-1" }, "locus": { "chromosome": "23", "start_pos": 7486127, "end_pos": 7483272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091419.1" } ] } }, { "isoform_ac": "A0AAA9TD30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#A0AAA9TD30-1", "sequence": { "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASASATTVTTAAATSVTVPGAGVPSGSGGTVAPATVSSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRTGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIVPQKHWVYVKRGGNCPASAPLAPQDPDLEEEEEEEDLVLTCEDDEDEELGGGSGVPARGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPGAGLDDSGGPTPSSYAPAHPPRPLLPLDMQGNQILIFPSSSSSSSSSQPPGNQAEHGAVTLGGTLAGALGGPGGTGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHHLGGGGGGGPGPGGGPSGPALQPKRESPCGGGGSGDEASGATPPSSRCVWSPLSVHKVEMGFSGGGGAN", "length": 634, "header": "tr|A0AAA9TD30-1|A0AAA9TD30_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 22 OS=Bos taurus OX=9913 GN=ZBTB22 PE=3 SV=1 CANONICAL=A0AAA9TD30-1" }, "locus": { "chromosome": "23", "start_pos": 7486127, "end_pos": 7484226, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088140.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088140.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094656.1" } ] } }, { "isoform_ac": "F1MLP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30/entry#F1MLP0-1", "sequence": { "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASASATTVTTAAATSVTVPGAGVPSGSGGTVAPATVSSVRSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRTGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIVPQKHWVYVKRGGNCPASAPLAPQDPDLEEEEEEEDLVLTCEDDEDEELGGGSGVPARGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPGAGLDDSGGPTPSSYAPAHPPRPLLPLDMQGNQILIFPSSSSSSSSSQPPGNQAEHGAVTLGGTLAGALGGPGGTGGTPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHHLGGGGGGGPGPGGGPSGPALQPKRESPCGGGGSGDEASGATPPSSRCVWSPLSVHKPERGFPPPHLLAFGGK", "length": 638, "header": "tr|F1MLP0-1|F1MLP0_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 22 OS=Bos taurus OX=9913 GN=ZBTB22 PE=3 SV=3 CANONICAL=A0AAA9TD30-1" }, "locus": { "chromosome": "23", "start_pos": 7486127, "end_pos": 7483272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022387.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022387.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022387.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022387.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 404, "start_aa": "Thr", "end_pos": 404, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr404", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 471, "start_aa": "Thr", "end_pos": 471, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr471", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 607, "start_aa": "Thr", "end_pos": 607, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr607", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538456", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538456", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O15209-1", "protein_name": "Zinc finger and BTB domain-containing protein 22", "gene_name": "ZBTB22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN", "length": 634 }, "evidence": [ { "id": "A0AAA9TD30", "url": "https://omabrowser.org/oma/group/A0AAA9TD30/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LUU5-1", "protein_name": "Zinc finger and BTB domain-containing protein 22b", "gene_name": "zbtb22b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQSATADQTFVDSTGSVVQVCFPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVMDPLAFESVLSCAYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLKEGKGGSSGPQGSGEKENIGQGSGTNKVAQADGGEAPSTPQPPSRPSFSESQSPSSTNYFSPRDANFGGAMVSTIAVGEGAVHSTPSYCMPSGGEEGFMIEDEEDDDDELLFSRKRDRGGKQKSTSSVSDQEVGVSDSFGVSSYQDGDSSPPQKHPSYIQPSIMPRKQWVVVKTEHSRDDDLIVVSGGEEGGDDEEEREMAIVRERDRTFNISNVRTLSGLREDAEMDAQVDYCQSSEDYLKFERGIIDQTSSQHPPENSSQCPNRAMSGMLGSVQSTSARAQLFPLDMQGNQILLYNQAALESTSPLGLTGGMSGVSLKGSLEHGAVHLPSQGALGSGMEGLDAGSAGSSGKVFMCHCGKTFTHKSMRDRHINMHLNLRPFHCPVCAKKFKMKHHLTEHMKTHTGLKPYDCHGCGKKFMWRDSFMRHRSHCERRGRSERASERSVISPPHHLKLPSASEPNQGGAGARSGLPILSPQHSISSNGVSCLSMAASGSLLGMSSQSGSHSLGSGILGIGGNRSGCVEDVCEENVDESSVT", "length": 671 }, "evidence": [ { "id": "A0AAA9TD30", "url": "https://omabrowser.org/oma/group/A0AAA9TD30/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6MGC7-1", "protein_name": "Zinc finger and BTB domain-containing protein 22", "gene_name": "Zbtb22", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPSPMSPSGATLPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRSSAATTTVTAVAAPSVSVPCASVPSGSGGTVAPATVGSVRSHTSSRASENQSPSSSNYFSPRESTDFSSSSQDAFVASAVGSGNRRDGGPVFPVPVVGSAGTTSGKLLLEADELCDDGGDGRGAAAPGAGLRRPNCLPASAVPQKHWVYVKRARNCPAPASLVHQDPDLEDEEEEEDLVLTCEDDEDEDLGNGSGVPAGGEPEATLSISDVRTLTEPAEKGEEQVNFCESSNDFGPYEGGGAGAGLDDPGGPTPSSYGLTHPPRPLLPLDVPGNQILVFPSSSSQAPGQPPGNTAEHGAVTLGGASAVGLGIPSGSGGTPGGAGNSDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHRMGAGGAASVPGPGPGAPTGPALQPKRESSAVGGGSGDEANSATPPSNRRVWSPPSVHKVEMDFSGGGGAAH", "length": 636 }, "evidence": [ { "id": "A0AAA9TD30", "url": "https://omabrowser.org/oma/group/A0AAA9TD30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Z0G7-1", "protein_name": "Zinc finger and BTB domain-containing protein 22", "gene_name": "Zbtb22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPSALSPSGATLPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRSAATTTTVTTAAAPSVSVPCASVPSGNGGTVAPATVGSVRSHTSSRASENQSPSSSNYFSPRESTDFSSTSQDAFVASAAGSGNRRDGGPVFPAPVVGSAGTTSGKLLLEADELCDDGGDGRGAVAPGAGLRRSNCMPASAVPQKHWVYVKQARNCPAPASLVHQDPDLEDEEEEEDLVLTCEDDEDEEMGGGSGVPAGGEPEATLSISDVRTLTEPADKGEEQVNFCESSNDFGPYEGGGAGAGLDDPGGPTPSSYALTHPPRPLLPLDVPGNQILVFPSSSSQAPGQPPGNTAEHGAVTLGGTSAVGLGIPSGSGGAPGGTGNSDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECSVCAKKFMWRDSFMRHRGHCERRHRMGVGGVGSGPGPGPGPGTPSGPALQPKRESSTVGGGSGDEANSATPPSHRRVWSPPSVHKVEMDFSGGGGAAH", "length": 638 }, "evidence": [ { "id": "A0AAA9TD30", "url": "https://omabrowser.org/oma/group/A0AAA9TD30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 121, "start_aa": "Cys", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TD30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD30" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 484, "end_pos": 510, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 404, 471, 607 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 201, "end_pos": 203 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TC74-1", "uniprot_ac": "A0AAA9TC74", "uniprot_id": "A0AAA9TC74_BOVIN", "mass": { "chemical_mass": 31176.0, "monoisotopic_mass": 31176.0 }, "refseq": {}, "gene_names": [ { "name": "AP3S1", "type": "recommended", "evidence": [ { "id": "A0AAA9TC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ] } ], "protein_names": [ { "name": "Adaptor related protein complex 3 subunit sigma 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RTN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTN1#function" }, { "database": "UniProtKB", "id": "ARBA00025605", "url": "https://www.uniprot.org/uniprotkb/ARBA00025605#function" }, { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74#function" }, { "database": "UniProtKB", "id": "A0AAA9TPE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPE0#function" }, { "database": "UniProtKB", "id": "A0AAF6ZVD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVD1#function" }, { "database": "UniProtKB", "id": "A0ABI0P2X2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2X2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AP3S1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74", "locus": {} } ], "crossref": [ { "id": "A0AAA9TC74", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TC74", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14834", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14834", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000804", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000804", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027155", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027155", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RTN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZVD1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZVD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZVD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2X2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2X2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2X2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DPGEGGVVGGRQRPPGDPLRRVAALLAPRPPRAPGCQPPGGCAGCPPPAALPSSDVAFLRRLLRLSVGWVASRLCGRGPGDFPVRGRSGSGGCSPPERAGFAAHPGLQPAPVSSRGRLLEPSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 291, "header": "tr|A0AAA9TC74-1|A0AAA9TC74_BOVIN Isoform 1 of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#A0AAA9RTN1-1", "sequence": { "sequence": "KLLFFLVSPTGSSVPGETAAEEGGSGVAVSGETSVGTSASGAVEGGSCSADSCSSAILLGGKGGRKRWLSECSGRALLQRTSLERHRGRGGGEPNPDSESQSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 271, "header": "tr|A0AAA9RTN1-1|A0AAA9TC74_BOVIN Computationally mapped isoform of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "locus": { "chromosome": "10", "start_pos": 4778016, "end_pos": 4702332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075301.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075301.1" } ] } }, { "isoform_ac": "A0AAA9TC74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#A0AAA9TC74-1", "sequence": { "sequence": "DPGEGGVVGGRQRPPGDPLRRVAALLAPRPPRAPGCQPPGGCAGCPPPAALPSSDVAFLRRLLRLSVGWVASRLCGRGPGDFPVRGRSGSGGCSPPERAGFAAHPGLQPAPVSSRGRLLEPSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 291, "header": "tr|A0AAA9TC74-1|A0AAA9TC74_BOVIN Isoform 1 of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "locus": { "chromosome": "10", "start_pos": 4778016, "end_pos": 4703077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127059.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127059.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093699.1" } ] } }, { "isoform_ac": "A0AAA9TPE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#A0AAA9TPE0-1", "sequence": { "sequence": "MTSSLSCSPQEEAFLLESHLYFAWLNTASRLCRRGSDAPLCSIIFFSTWFGEAGELAQQMKSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 231, "header": "tr|A0AAA9TPE0-1|A0AAA9TPE0_BOVIN Computationally mapped isoform of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "locus": { "chromosome": "10", "start_pos": 4778016, "end_pos": 4712543, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102920.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102920.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099137.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099137.1" } ] } }, { "isoform_ac": "A0AAF6ZVD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#A0AAF6ZVD1-1", "sequence": { "sequence": "MQAPPRISGARARACARGGGWGRTAGEIRRRGSRARPRPGPQLPPGPPGSAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 244, "header": "tr|A0AAF6ZVD1-1|A0AAF6ZVD1_BOVIN Computationally mapped isoform of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "locus": { "chromosome": "10", "start_pos": 4778016, "end_pos": 4702836, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068637.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068637.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058473.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058473.2" } ] } }, { "isoform_ac": "A0ABI0P2X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74/entry#A0ABI0P2X2-1", "sequence": { "sequence": "PFQRLSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK", "length": 175, "header": "tr|A0ABI0P2X2-1|A0ABI0P2X2_BOVIN Computationally mapped isoform of Adaptor related protein complex 3 subunit sigma 1 OS=Bos taurus OX=9913 GN=AP3S1 PE=3 SV=1 CANONICAL=A0AAA9TC74-1" }, "locus": { "chromosome": "10", "start_pos": 4778016, "end_pos": 4703808, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149003.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149003.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107693.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "pmid": "" }, { "name": "Golgi to vacuole transport", "id": "GO:0006896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006896", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TC74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC74" }, { "id": "PF01217", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AP complex mu/sigma subunit", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 245, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9P3-1", "uniprot_ac": "A0AAA9T9P3", "uniprot_id": "A0AAA9T9P3_BOVIN", "mass": { "chemical_mass": 65019.0, "monoisotopic_mass": 65019.0 }, "refseq": { "ac": "XP_002689529", "name": "scavenger receptor class A member 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689529" }, "gene_names": [ { "name": "SCARA3", "type": "recommended", "evidence": [ { "id": "A0AAA9T9P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ] }, { "name": "SCARA3", "type": "synonym", "evidence": [ { "id": "XP_002689529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689529" } ] } ], "protein_names": [ { "name": "Scavenger receptor class A member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T9P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3/entry#names_and_taxonomy" } ] }, { "name": "scavenger receptor class A member 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689529", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689529" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCARA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3", "locus": { "chromosome": "8", "start_pos": 11117875, "end_pos": 11159386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007657", "url": "https://www.ensembl.org/id/ENSBTAG00000007657" } ] } } ], "crossref": [ { "id": "A0AAA9T9P3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9P3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007657", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007657", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541156", "url": "https://www.ncbi.nlm.nih.gov/gene/541156", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541156", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541156", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DLAQECY", "url": "https://omabrowser.org/oma/group/DLAQECY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMG6", "url": "https://www.orthodb.org/?gene=F1MMG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR39082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR39082:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR39082:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689529", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689529", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RVH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMG6", "url": "https://www.uniprot.org/uniprotkb/F1MMG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMG6-1", "url": "https://www.uniprot.org/uniprotkb/F1MMG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVRSAAGDGDALCVTEEELAADDEDMPSFPCTQEGQPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDLSLAQAMYDKKLVSMQKNLQGLDLKARNNCSFCHEAGLLGQEIRKLQAELEGIQKMLLAQEVQLHQTSQTHDLLSTTSGQISQEMGSCSFSVHQINQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFGSLRTTSAKTGEAVRSLQATLGASSQRISQNSESLHDLVLQAMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTQAEELYYLNKTVSLMLAATDLLRERFSLLSARLDLNVRNLSMIVEEMRAVDTRHGEILRNVTILRGAPGPPGPRGLKGDVGVKGPAGGKGPKGDPGSLGPPGPQGPQGQPGEPGPVGERGPVGPRGFPGLKGSKGSFGTVGARGQPGPKGDVGPPGPEGPPGAPGPEGPQGEPGIAGKTGSPGQRGPMGPKGEPGIQGPPGFPGPPGPPGSQSSY", "length": 606, "header": "tr|A0AAA9T9P3-1|A0AAA9T9P3_BOVIN Isoform 1 of Scavenger receptor class A member 3 OS=Bos taurus OX=9913 GN=SCARA3 PE=4 SV=1 CANONICAL=A0AAA9T9P3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3/entry#A0AAA9RVH6-1", "sequence": { "sequence": "MKVRSAAGDGDALCVTEEELAADDEDMPSFPCTQEGQPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLDLKARNNCSFCHEAGLLGQEIRKLQAELEGIQKMLLAQEVQLHQTSQTHDLLSTTSGQISQEMGSCSFSVHQINQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFGSLRTTSAKTGEAVRSLQATLGASSQRISQNSESLHDLVLQAMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTQAEELYYLNKTVSLMLAATDLLRERFSLLSARLDLNVRNLSMIVEEMRAVDTRHGEILRNVTILRGAPGPPGPRGLKGDVGVKGPAGGKGPKGDPGSLGPPGPQGPQGQPGEPGPVGERGPVGPRGFPGLKGSKGSFGTVGARGQPGPKGDVGPPGPEGPPGAPGPEGPQGEPGIAGKTGSPGQRGPMGPKGEPGIQGPPGFPGPPGPPGSQSSY", "length": 573, "header": "tr|A0AAA9RVH6-1|A0AAA9T9P3_BOVIN Computationally mapped isoform of Scavenger receptor class A member 3 OS=Bos taurus OX=9913 GN=SCARA3 PE=4 SV=1 CANONICAL=A0AAA9T9P3-1" }, "locus": { "chromosome": "8", "start_pos": 11159059, "end_pos": 11125662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110501.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110501.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074979.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074979.1" } ] } }, { "isoform_ac": "A0AAA9SIC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3/entry#A0AAA9SIC1-1", "sequence": { "sequence": "MKGQPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDLSLAQAMYDKKLVSMQKNLQGLDLKARNNCSFCHEAGLLGQEIRKLQAELEGIQKMLLAQEVQLHQTSQTHDLLSTTSGQISQEMGSCSFSVHQINQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFGSLRTTSAKTGEAVRSLQATLGASSQRISQNSESLHDLVLQAMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTQAEELYYLNKTVSLMLAATDLLRERFSLLSARLDLNVRNLSMIVEEMRAVDTRHGEILRNVTILRGAPGPPGPRGLKGDVGVKGPAGGKGPKGDPGSLGPPGPQGPQGQPGEPGPVGERGPVGPRGFPGLKGSKGSFGTVGARGQPGPKGDVGPPGPEGPPGAPGPEGPQGEPGIAGKTGSPGQRGPMGPKGEPGIQGPPGFPGPPGPPGSQSSY", "length": 573, "header": "tr|A0AAA9SIC1-1|A0AAA9T9P3_BOVIN Computationally mapped isoform of Scavenger receptor class A member 3 OS=Bos taurus OX=9913 GN=SCARA3 PE=4 SV=1 CANONICAL=A0AAA9T9P3-1" }, "locus": { "chromosome": "8", "start_pos": 11159059, "end_pos": 11125662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092410.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092410.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083659.1" } ] } }, { "isoform_ac": "A0AAA9T9P3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3/entry#A0AAA9T9P3-1", "sequence": { "sequence": "MKVRSAAGDGDALCVTEEELAADDEDMPSFPCTQEGQPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDLSLAQAMYDKKLVSMQKNLQGLDLKARNNCSFCHEAGLLGQEIRKLQAELEGIQKMLLAQEVQLHQTSQTHDLLSTTSGQISQEMGSCSFSVHQINQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFGSLRTTSAKTGEAVRSLQATLGASSQRISQNSESLHDLVLQAMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTQAEELYYLNKTVSLMLAATDLLRERFSLLSARLDLNVRNLSMIVEEMRAVDTRHGEILRNVTILRGAPGPPGPRGLKGDVGVKGPAGGKGPKGDPGSLGPPGPQGPQGQPGEPGPVGERGPVGPRGFPGLKGSKGSFGTVGARGQPGPKGDVGPPGPEGPPGAPGPEGPQGEPGIAGKTGSPGQRGPMGPKGEPGIQGPPGFPGPPGPPGSQSSY", "length": 606, "header": "tr|A0AAA9T9P3-1|A0AAA9T9P3_BOVIN Isoform 1 of Scavenger receptor class A member 3 OS=Bos taurus OX=9913 GN=SCARA3 PE=4 SV=1 CANONICAL=A0AAA9T9P3-1" }, "locus": { "chromosome": "8", "start_pos": 11159059, "end_pos": 11125662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134266.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134266.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092627.1" } ] } }, { "isoform_ac": "F1MMG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3/entry#F1MMG6-1", "sequence": { "sequence": "MKVRSAAGDGDALCVTEEELAADDEDMPSFPCTQEGQPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDLSLAQAMYDKKLVSMQKNLQGLDLKARNNCSFCHEAGLLGQEIRKLQAELEGIQKMLLAQEVQLHQTSQTHDLLSTTSGQISQEMGSCSFSVHQINQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFGSLRTTSAKTGEAVRSLQATLGASSQRISQNSESLHDLVLQAMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTQAEELYYLNKTVSLMLAATDLLRERFSLLSARLDLNVRNLSMIVEEMRAVDTRHGEILRNVTILRGHTLFSHNQI", "length": 466, "header": "tr|F1MMG6-1|A0AAA9T9P3_BOVIN Computationally mapped isoform of Scavenger receptor class A member 3 OS=Bos taurus OX=9913 GN=SCARA3 PE=4 SV=3 CANONICAL=A0AAA9T9P3-1" }, "locus": { "chromosome": "8", "start_pos": 11159059, "end_pos": 11117878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010075.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010075.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010075.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010075.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541156", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541156", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AYV9-1", "protein_name": "Scavenger receptor class A member 3", "gene_name": "SCARA3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKVRSAAGDGDALCVTEEELAGDDEDMPSFPCTQEGRPGPRCSRCQRNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDISLAQAIYDKKLVSMQENLQGLDLKAPNNCSFCYEAGQLGQEIRKLQEELEGIQKMLLAQEVQLDQASQTQELLSTTSGQISQEMGSCSFSIHQVNQSLGLFLAQVKGWQTTTASLDLSLKDLTQECYDVKAAMHQINFTVGQTSEWIHGIRRKTDEETLTLQKMVTDWQNYTRLFSSLRTTSAKTGEAVKNIQATLGVSSQRISQNAESMHDLVLQVMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFETLEGRMASHEIEIGTIFTNINATDSHVYSMLKYLDDVRLSCTLGFHTHAEELYYLNKSVSLMLATTDLLRERFGLLSARLDFNVRNLSMIVEEMKAVDTQHGEILRNVTILRGAPGPPGPRGLKGDVGVKGPTGSRGPKGDPGSLGPPGPQGPQGQPGDTGPVGERGPVGLRGFPGLKGSKGSFGTGGPRGQPGPKGDVGPPGPEGPQGSPGPEGPQGKPGIAGKTGSPGQRGPVGPKGEPGIQGPPGLPGPPGPPGSQSHY", "length": 606 }, "evidence": [ { "id": "A0AAA9T9P3", "url": "https://omabrowser.org/oma/group/A0AAA9T9P3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y0D6-1", "protein_name": "Scavenger receptor class A member 3", "gene_name": "SCARA3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGRGPSRHPWCSNLSAEGWLWGRGPGGRRRGGDAILPLPTERARGGCSQCQKNLSLQMAIKVLYVFSVLLIVAVTVLAALVFKKVNSISGDISSAQMYYEEKILSIQEDLQELDEKSSGNCSLCLETGQLGQELGKLQGELEEIQKMLLVQEVLLNRTSRTHDVLSSSSTEISSEVADCSSSTRQLNESVGQLVAQLGGWRAITSQLDGSLKGLEQERFDVRAAMQQLNFTLGQTSDWIQLIQRKTDEETLTLQKMVTEWQNYTRLFAGLRANSAETGELVRSIQVGVGAAARQVGQNAEGMHDLVLQVMGLQLQLDNISSFLDDHEENMNDLRYHAKYAQNRTAERFETLEGRMASHEIEIGTIFTNINATDSHVHSMLRYLDDVRLSCTLGFHAHAEELYYLNKSLSLVQGTTDLLRERFGLLSARLDFDIRNLSMVMEEMKVVDVRHGEMLRNITILRGVPGLPGPRGLKGDVGIKGPAGSKGEKGDAGSLGSPGPPGSPGPPGPPGPQGERGPLGAKGFPGLKGAKGSFGQSGSRGQMGPKGDVGPPGPEGGPGPTGPPGPQGKLGLPGNPGAVGQIGPMGPKGDPGLRGPPGPPGPPGPPGP", "length": 607 }, "evidence": [ { "id": "A0AAA9T9P3", "url": "https://omabrowser.org/oma/group/A0AAA9T9P3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9QDK3-1", "protein_name": "Scavenger receptor class A member 3 isoform X1", "gene_name": "scara3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKDSYCGYENQLFNEEDLTGEEEEIPPLRGRARGGCMKCQQTHSLQLAVKMLYGFLALLIIAVAVLASLVFRRVDSLYEDESFYHKQMSKVEESVKDIRTASNYSTCLDVAQFQEEIARLKKEFEEIQKTILSQEQQMNEATQSQQSLTQSSKRMARDFQALGMIIKSVNQSLSQYLNQVSGWQVVINETDHGMKTLVEDQHDLKATVQQVNTTVALSGLWIGALQRKAEEETLVLQKITADWQNYSRVLSTLKTNTSITMQNLRVVQNSISATQQRISTSSEMVHDLTLQVMNLQMQLDNVSSYIDEHEENMHDHQYHAKYYENRTGERFVTLDARMDSIEHEIDTISSSINATVNHVQSMYKYINMESSSCQSRLGSHTEDLQNLNNTVLLLLHLADTLRLQHMMLNERLENDVRSLTVVTEEMKLVDTSHAELIQNFTILKGLPGPPGPKGNRGESGAKGFGGLMGMKGERGIAGNRGPQGLKGSMGIKGDQGLLGVSGMKGGPGVKGEKGSLGQPGPRGEKGQKGDMGVSGKDGIPGPKGPTGIRGQAGLPGVHGPSGTVGIPGPVGPPGPAGPPGPPGEAV", "length": 586 }, "evidence": [ { "id": "A0AAA9T9P3", "url": "https://omabrowser.org/oma/group/A0AAA9T9P3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6AZY7-1", "protein_name": "Scavenger receptor class A member 3", "gene_name": "SCARA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVRSAGGDGDALCVTEEDLAGDDEDMPTFPCTQKGRPGPRCSRCQKNLSLHTSVRILYLFLALLLVAVAVLASLVFRKVDSLSEDISLTQSIYDKKLVLMQKNLQGLDPKALNNCSFCHEAGQLGPEIRKLQEELEGIQKLLLAQEVQLDQTLQAQEVLSTTSRQISQEMGSCSFSIHQVNQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIQRKTDEETLTLQKIVTDWQNYTRLFSGLRTTSTKTGEAVKNIQATLGASSQRISQNSESMHDLVLQVMGLQLQLDNISSFLDDHEENMHDLQYHTHYAQNRTVERFESLEGRMASHEIEIGTIFTNINATDNHVHSMLKYLDDVRLSCTLGFHTHAEELYYLNKSVSIMLGTTDLLRERFSLLSARLDLNVRNLSMIVEEMKAVDTQHGEILRNVTILRGAPGPPGPRGFKGDMGVKGPVGGRGPKGDPGSLGPLGPQGPQGQPGEAGPVGERGPVGPRGFPGLKGSKGSFGTGGPRGQPGPKGDIGPPGPEGPPGSPGPSGPQGKPGIAGKTGSPGQRGAMGPKGEPGIQGPPGLPGPPGPPGSQSFY", "length": 606 }, "evidence": [ { "id": "A0AAA9T9P3", "url": "https://omabrowser.org/oma/group/A0AAA9T9P3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C850-1", "protein_name": "Scavenger receptor class A member 3", "gene_name": "Scara3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKVRSAGSDRDVLCVTEEDLAGEDEDMPSFPCTQEGRAGPRCNRCQKNLSLHTSVRILYLFLTLLLVAVAVLASLVFRKVDSLSEDISLAQSIYNKKLVSMQENLQGLDPKALINCSFCREAEQLGQEIRKVQEELEGLQKMLLAQEVQLDQTSQTHELLSTRSSQISQEMGSCSFSIHQVNQSLGLFLAQVRGWQATTAGMDITLKDLTQECYDVKAAVHQINFTVGQTAEWIHGIQRKTDEETLTLQKIVTDWQNYTRLFGGLRTTSAKTGEIVKTIQTTLGASSQRISQNSESMHDLVLQVMGLQLQLDNISSFLDDHEENMHDLQYHTRYAQNRTVERFESLEGRMASHEIEIGTIFTNINATDNHVHSMLKYLDDVRLSCTLGFHTHAEELYYLNKSVSLMLGTTDLLRERFSLLSARLDFNVRNLSMIMEEMKAVDTHHGEILRNVTVIRGVPGPPGPRGLKGDTGVKGPVGSRGPKGDPGNLGPPGPQGPQGQPGEPGPVGERGPAGPRGFPGLKGSKGSFGTGGPRGQPGPKGDVGPLGPEGPPGSPGPSGPQGKPGISGKTGSPGQRGATGPKGEPGIQGPPGLPGPPGPPGNQSPY", "length": 606 }, "evidence": [ { "id": "A0AAA9T9P3", "url": "https://omabrowser.org/oma/group/A0AAA9T9P3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9P3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9P3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 182, "end_pos": 184 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 313, "end_pos": 315 }, { "start_pos": 337, "end_pos": 339 }, { "start_pos": 365, "end_pos": 367 }, { "start_pos": 400, "end_pos": 402 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 48, "end_pos": 50 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDG6-1", "uniprot_ac": "A0AAA9TDG6", "uniprot_id": "A0AAA9TDG6_BOVIN", "mass": { "chemical_mass": 23202.0, "monoisotopic_mass": 23202.0 }, "refseq": {}, "gene_names": [ { "name": "EFCAB2", "type": "recommended", "evidence": [ { "id": "A0AAA9TDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" } ] } ], "protein_names": [ { "name": "EF-hand calcium binding domain 2", "type": "synonym", "evidence": [ { "id": "A0AAA9TDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFCAB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6", "locus": { "chromosome": "16", "start_pos": 32202902, "end_pos": 32318844, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024555", "url": "https://www.ensembl.org/id/ENSBTAG00000024555" } ] } } ], "crossref": [ { "id": "A0AAA9TDG6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46763:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46763:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RWK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S068", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S068", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S068-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S068-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TVAHQVPLSKGFSRQEYWSGLPFPSPGDLPNPGTESTSPALAGGFFTTEPPEVAVAEFHKKIKEAFEVFDHESNNTVDVREVGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEVLLERRYRPIPEDILLRAFEVLDPAKRGFLSKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN", "length": 205, "header": "tr|A0AAA9TDG6-1|A0AAA9TDG6_BOVIN Isoform 1 of EF-hand calcium binding domain 2 OS=Bos taurus OX=9913 GN=EFCAB2 PE=4 SV=1 CANONICAL=A0AAA9TDG6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6/entry#A0AAA9RWK9-1", "sequence": { "sequence": "SLGAGGEHWTGENVGRRWGRWEGEAAALRVASVTPPESSSPPALQLRFKICSKKREVGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEVLLERRYRPIPEDILLRAFEVLDPAKRGFLSKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN", "length": 180, "header": "tr|A0AAA9RWK9-1|A0AAA9TDG6_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 2 OS=Bos taurus OX=9913 GN=EFCAB2 PE=4 SV=1 CANONICAL=A0AAA9TDG6-1" }, "locus": { "chromosome": "16", "start_pos": 32314338, "end_pos": 32203147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132910.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132910.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075508.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075508.1" } ] } }, { "isoform_ac": "A0AAA9S068-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6/entry#A0AAA9S068-1", "sequence": { "sequence": "NLNLLEDGKERKEEVAVAEFHKKIKEAFEVFDHESNNTVDVREVGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEVLLERRYRPIPEDILLRAFEVLDPAKRGFLSKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN", "length": 167, "header": "tr|A0AAA9S068-1|A0AAA9TDG6_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 2 OS=Bos taurus OX=9913 GN=EFCAB2 PE=4 SV=1 CANONICAL=A0AAA9TDG6-1" }, "locus": { "chromosome": "16", "start_pos": 32318653, "end_pos": 32203147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132818.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132818.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077020.1" } ] } }, { "isoform_ac": "A0AAA9TDG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6/entry#A0AAA9TDG6-1", "sequence": { "sequence": "TVAHQVPLSKGFSRQEYWSGLPFPSPGDLPNPGTESTSPALAGGFFTTEPPEVAVAEFHKKIKEAFEVFDHESNNTVDVREVGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEVLLERRYRPIPEDILLRAFEVLDPAKRGFLSKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN", "length": 205, "header": "tr|A0AAA9TDG6-1|A0AAA9TDG6_BOVIN Isoform 1 of EF-hand calcium binding domain 2 OS=Bos taurus OX=9913 GN=EFCAB2 PE=4 SV=1 CANONICAL=A0AAA9TDG6-1" }, "locus": { "chromosome": "16", "start_pos": 32315523, "end_pos": 32203147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134663.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134663.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094181.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094181.1" } ] } }, { "isoform_ac": "A0AAA9TTV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6/entry#A0AAA9TTV2-1", "sequence": { "sequence": "MPSSRGSLRPRDGPASLMSPPLAEVAVAEFHKKIKEAFEVFDHESNNTVDVREVGTIIRSLGCCPSEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEVLLERRYRPIPEDILLRAFEVLDPAKRGFLSKDELIKYMTEEGEPFSQEEMEEMLSAAIDPESNSIHYKDYITMMVIDEN", "length": 177, "header": "tr|A0AAA9TTV2-1|A0AAA9TTV2_BOVIN Computationally mapped isoform of EF-hand calcium binding domain 2 OS=Bos taurus OX=9913 GN=EFCAB2 PE=4 SV=1 CANONICAL=A0AAA9TDG6-1" }, "locus": { "chromosome": "16", "start_pos": 32306091, "end_pos": 32203147, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091839.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091839.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101792.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "organelle", "id": "GO:0043226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043226", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDG6" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 57, "end_pos": 92, "start_aa": "Glu", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 74, "end_pos": 76 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDA2-1", "uniprot_ac": "A0AAA9TDA2", "uniprot_id": "A0AAA9TDA2_BOVIN", "mass": { "chemical_mass": 76281.0, "monoisotopic_mass": 76281.0 }, "refseq": { "ac": "XP_002695718", "name": "FMR1-interacting protein NUFIP2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695718" }, "gene_names": [ { "name": "NUFIP2", "type": "recommended", "evidence": [ { "id": "A0AAA9TDA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ] }, { "name": "NUFIP2", "type": "synonym", "evidence": [ { "id": "XP_002695718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695718" } ] } ], "protein_names": [ { "name": "FMR1-interacting protein NUFIP2", "type": "synonym", "evidence": [ { "id": "XP_002695718", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695718" } ] }, { "name": "Nuclear FMR1 interacting protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9TDA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NUFIP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2", "locus": { "chromosome": "19", "start_pos": 20599561, "end_pos": 20620326, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033077", "url": "https://www.ensembl.org/id/ENSBTAG00000033077" } ] } } ], "crossref": [ { "id": "A0AAA9TDA2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "781847", "url": "https://www.ncbi.nlm.nih.gov/gene/781847", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781847", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781847", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MXK2", "url": "https://www.orthodb.org/?gene=F1MXK2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28333:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28333:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15293", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15293", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002695718", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695718", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RXP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXK2", "url": "https://www.uniprot.org/uniprotkb/F1MXK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXK2-1", "url": "https://www.uniprot.org/uniprotkb/F1MXK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEEKPGQPQSQHHHSHHHPHHHPQQQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHALQQHQETPKKKTGYGELNGNAGEREISLKSLGSEEATNPISRVLNGNQQVVDTNLKQTVKSSTFGKAGIKTRNFIQKNSMDKKNGKSYENKSGENQSIDKTDTVAIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNLVQDKIMQQETNVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDMLRKSSDIKPGVSSKKFDDRPKGKHTSAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTVQNSSVSPSSSSSSSSSTGETQTQASSRLSQVPMSALKSVTSASFSNGPVLAGTDASVYSPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKSSLFIYPSNMQTVLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSDHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTNESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEVENQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESVWNLQKQDPKRIITYNEAMDSPDQ", "length": 697, "header": "tr|A0AAA9TDA2-1|A0AAA9TDA2_BOVIN Isoform 1 of Nuclear FMR1 interacting protein 2 OS=Bos taurus OX=9913 GN=NUFIP2 PE=4 SV=1 CANONICAL=A0AAA9TDA2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2/entry#A0AAA9RXP0-1", "sequence": { "sequence": "MEEKPGQPQSQHHHSHHHPHHHPQQQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHALQQHQETPKKKTEMESVWNLQKQDPKRIITYNEAMDSPDQ", "length": 122, "header": "tr|A0AAA9RXP0-1|A0AAA9TDA2_BOVIN Computationally mapped isoform of Nuclear FMR1 interacting protein 2 OS=Bos taurus OX=9913 GN=NUFIP2 PE=4 SV=1 CANONICAL=A0AAA9TDA2-1" }, "locus": { "chromosome": "19", "start_pos": 20620127, "end_pos": 20600565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110404.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110404.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078286.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078286.1" } ] } }, { "isoform_ac": "A0AAA9TDA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2/entry#A0AAA9TDA2-1", "sequence": { "sequence": "MEEKPGQPQSQHHHSHHHPHHHPQQQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHALQQHQETPKKKTGYGELNGNAGEREISLKSLGSEEATNPISRVLNGNQQVVDTNLKQTVKSSTFGKAGIKTRNFIQKNSMDKKNGKSYENKSGENQSIDKTDTVAIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNLVQDKIMQQETNVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDMLRKSSDIKPGVSSKKFDDRPKGKHTSAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTVQNSSVSPSSSSSSSSSTGETQTQASSRLSQVPMSALKSVTSASFSNGPVLAGTDASVYSPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKSSLFIYPSNMQTVLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSDHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTNESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEVENQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKEMESVWNLQKQDPKRIITYNEAMDSPDQ", "length": 697, "header": "tr|A0AAA9TDA2-1|A0AAA9TDA2_BOVIN Isoform 1 of Nuclear FMR1 interacting protein 2 OS=Bos taurus OX=9913 GN=NUFIP2 PE=4 SV=1 CANONICAL=A0AAA9TDA2-1" }, "locus": { "chromosome": "19", "start_pos": 20620127, "end_pos": 20600565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120992.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120992.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094732.1" } ] } }, { "isoform_ac": "F1MXK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2/entry#F1MXK2-1", "sequence": { "sequence": "MEEKPGQPQSQHHHSHHHPHHHPQQQQQQQQPHHHHHYYFYNHSHNHHHHHHHQQPHQYLQHGAEGSPKAQPKPLKHEQKHALQQHQETPKKKTGYGELNGNAGEREISLKSLGSEEATNPISRVLNGNQQVVDTNLKQTVKSSTFGKAGIKTRNFIQKNSMDKKNGKSYENKSGENQSIDKTDTVAIPNGVVTNNSGYITNGYMGKGADNDGSGSESGYTTPKKRKARRNSAKGCENLNLVQDKIMQQETNVPTLKQGLETFKPDYSEQKGNRVDGSKPIWKYETGPGGTSRGKPAVGDMLRKSSDIKPGVSSKKFDDRPKGKHTSAVASKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKTVQNSSVSPSSSSSSSSSTGETQTQASSRLSQVPMSALKSVTSASFSNGPVLAGTDASVYSPGGQPLLTTAANTLTPISSGTDSVLQDMSLTSAAVEQIKSSLFIYPSNMQTVLLSTAQVDLPSQTDQQNLGDIFQNQWGLSFINEPSAGPETVTGKSSDHKVMEVTFQGEYPATLVSQGAEIIPSGTEHPVFPKAYELEKRTSPQVLGSILKSGTTNESGALSLEPSHIGDLQKADTSSQGALVFLSKDYEVENQNPLASPTNTLLGSAKEQRYQRGLERNDSWGSFDLRAAIVYHTKACICKCLLFVQIQFNLG", "length": 686, "header": "tr|F1MXK2-1|A0AAA9TDA2_BOVIN Computationally mapped isoform of Nuclear FMR1 interacting protein 2 OS=Bos taurus OX=9913 GN=NUFIP2 PE=4 SV=3 CANONICAL=A0AAA9TDA2-1" }, "locus": { "chromosome": "19", "start_pos": 20620127, "end_pos": 20602751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046961.4", "url": "https://www.ensembl.org/id/ENSBTAT00000046961.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044207.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044207.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781847", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781847", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 652, "end_pos": 654, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 }, { "start_pos": 177, "end_pos": 179 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 588, "end_pos": 590 }, { "start_pos": 652, "end_pos": 654 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCX3-1", "uniprot_ac": "A0AAA9TCX3", "uniprot_id": "A0AAA9TCX3_BOVIN", "mass": { "chemical_mass": 55101.0, "monoisotopic_mass": 55101.0 }, "refseq": {}, "gene_names": [ { "name": "C5H12orf50", "type": "recommended", "evidence": [ { "id": "A0AAA9TCX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3" } ] } ], "protein_names": [ { "name": "Chromosome 5 C12orf50 homolog", "type": "synonym", "evidence": [ { "id": "A0AAA9TCX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C5H12orf50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3", "locus": { "chromosome": "5", "start_pos": 17793281, "end_pos": 17823407, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018180", "url": "https://www.ensembl.org/id/ENSBTAG00000018180" } ] } } ], "crossref": [ { "id": "A0AAA9TCX3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018180", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018180", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR040943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15725", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15725", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15725:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15725:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYH6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T840", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T840", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T840-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T840-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7J9", "url": "https://www.uniprot.org/uniprotkb/E1B7J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7J9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVFFPNQWIVGSQCRFRHCEEALGSDTVCSLWREGKCLDPLCRFRHMEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSNIILQKETQEGIPPPTQSQEPLKPQENISRPIHHPLVLKTNFEEEEEEEGEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRVHTPSDISSSKSIASIVEKEIEKSLESGSELQEGDGLTVPTKFSLFERQGEIKASLDRKPRTDIAAFENGGGDCYVPQRIIFLGVDENEVLTEEKESTISKCSNAKDNKDSPHPKRSLTTRLVSTRHVLNATENISMKCREDLSSMNDVHPVMKPHFKGVKKRKWIYDEPKNFPDPGMQRAVQASNPKNKMSYHRNNKNKNSENASYIHVQRDAVRTVSLNAPPHGRPPHGSYNKADVNKEPKFKLCSDKYMSTSYNGSAWQKRIPFSKTYSKNEKIYTGHSGEIAAFPSGQMACGERRQKTRAATSLFL", "length": 484, "header": "tr|A0AAA9TCX3-1|A0AAA9TCX3_BOVIN Isoform 1 of Chromosome 5 C12orf50 homolog OS=Bos taurus OX=9913 GN=C5H12orf50 PE=4 SV=1 CANONICAL=A0AAA9TCX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYH6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3/entry#A0AAA9RYH6-1", "sequence": { "sequence": "MVFFPNQWIVGSQCRFRHCEEALGSDTVCSLWREGKCLDPLCRFRHMEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSNIILQKETQEGIPPPTQSQEPLKPQENISRPIHHPLVLKTNFEEEEEEEGEQNDYLALGQFNLKKIYPIDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRVHTPSDISSSKSIASIVEKEIEKSLESGSELQEGDGLTVPTKFSLFERQGEIKASLDRKPRTDIAAFENGGGDCYVPQRIIFLGVDENEVLTEEKESTISKCSNAKVNDVHPVMKPHFKGVKKRKWIYDEPKNFPDPGMQRAVQASNPKNKMSYHRNNKNKNSENASYIHVQRDAVRTVSLNAPPHGRPPHGSYNKADVNKEPKFKLCSDKYMSTSYNGSAWQKRIPFSKTYSKNEKIYTEPRRNGSK", "length": 438, "header": "tr|A0AAA9RYH6-1|A0AAA9TCX3_BOVIN Computationally mapped isoform of Chromosome 5 C12orf50 homolog OS=Bos taurus OX=9913 GN=C5H12orf50 PE=4 SV=1 CANONICAL=A0AAA9TCX3-1" }, "locus": { "chromosome": "5", "start_pos": 17823153, "end_pos": 17793476, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089973.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089973.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077662.1" } ] } }, { "isoform_ac": "A0AAA9T840-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3/entry#A0AAA9T840-1", "sequence": { "sequence": "MVFFPNQWIVGSQCRFRHCEEALGSDTVCSLWREGKCLDPLCRFRHMEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSNIILQKETQEGIPPPTQSQEPLKPQENISRPIHHPLVLKTNFEEEEEEEGEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRVHTPSDISSSKSIASIVEKEIEKSLESGSELQEGDGLTVPTKFSLFERQGEIKASLDRKPRTDIAAFENGGGDCYVPQRIIFLGVDENEVLTEEKESTISKCSNAKDNKDSPHPKRSLTTRLVSTRHVLNATENISMKCREDLSSMNDVHPVMKPHFKGVKKRKWIYDEPKNFPDPGMQRAVQASNPKNKMSYHRNNKNKNSENASYIHVQRDAVRTVSLNAPPHGRPPHGSYNKADVNKEPKFKLCSDKYMSTSYNGSAWQKRIPFSKTYSKNEKIYTEPRRNGSK", "length": 461, "header": "tr|A0AAA9T840-1|A0AAA9TCX3_BOVIN Computationally mapped isoform of Chromosome 5 C12orf50 homolog OS=Bos taurus OX=9913 GN=C5H12orf50 PE=4 SV=1 CANONICAL=A0AAA9TCX3-1" }, "locus": { "chromosome": "5", "start_pos": 17823153, "end_pos": 17793476, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118999.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118999.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094125.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094125.1" } ] } }, { "isoform_ac": "A0AAA9TCX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3/entry#A0AAA9TCX3-1", "sequence": { "sequence": "MVFFPNQWIVGSQCRFRHCEEALGSDTVCSLWREGKCLDPLCRFRHMEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSNIILQKETQEGIPPPTQSQEPLKPQENISRPIHHPLVLKTNFEEEEEEEGEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRVHTPSDISSSKSIASIVEKEIEKSLESGSELQEGDGLTVPTKFSLFERQGEIKASLDRKPRTDIAAFENGGGDCYVPQRIIFLGVDENEVLTEEKESTISKCSNAKDNKDSPHPKRSLTTRLVSTRHVLNATENISMKCREDLSSMNDVHPVMKPHFKGVKKRKWIYDEPKNFPDPGMQRAVQASNPKNKMSYHRNNKNKNSENASYIHVQRDAVRTVSLNAPPHGRPPHGSYNKADVNKEPKFKLCSDKYMSTSYNGSAWQKRIPFSKTYSKNEKIYTGHSGEIAAFPSGQMACGERRQKTRAATSLFL", "length": 484, "header": "tr|A0AAA9TCX3-1|A0AAA9TCX3_BOVIN Isoform 1 of Chromosome 5 C12orf50 homolog OS=Bos taurus OX=9913 GN=C5H12orf50 PE=4 SV=1 CANONICAL=A0AAA9TCX3-1" }, "locus": { "chromosome": "5", "start_pos": 17823153, "end_pos": 17794028, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104498.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104498.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096510.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096510.1" } ] } }, { "isoform_ac": "E1B7J9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3/entry#E1B7J9-1", "sequence": { "sequence": "MEMQQNCSISCFWETQPLGCVKISCIFYHSKPRNINGLFLPPSSNIILQKETQEGIPPPTQSQEPLKPQENISRPIHHPLVLKTNFEEEEEEEGEQNDASSLWTKTPEEIEEKRAIKEMCYKSGEYYRVHTPSDISSSKSIASIVEKEIEKSLESGSELQEGDGLTVPTKFSLFERQGEIKASLDRKPRTDIAAFENGGGDCYVPQRIIFLGVDENEVLTEEKESTISKCSNAKVNDVHPVMKPHFKGVKKRKWIYDEPKNFPDPGMQRVQASNPKNKMSYHRNNKNKNSENASYIHVQRDAVRTVSLNAPPHGRPPHGSYNKADVNKEPKFKLCSDKYMSTSYNGSAWQKRIPFSKTYSKNEKIYTVSSLGGSK", "length": 375, "header": "tr|E1B7J9-1|E1B7J9_BOVIN Computationally mapped isoform of Chromosome 5 C12orf50 homolog OS=Bos taurus OX=9913 GN=C5H12orf50 PE=4 SV=3 CANONICAL=A0AAA9TCX3-1" }, "locus": { "chromosome": "5", "start_pos": 17820349, "end_pos": 17796589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047880.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047880.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045043.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045043.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "poly(A)+ mRNA export from nucleus", "id": "GO:0016973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016973", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", 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"https://www.ebi.ac.uk/interpro/entry/IPR003887", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BIJ4", "url": "https://www.orthodb.org/?gene=E1BIJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13428", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13428", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13428:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13428:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03020", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03020", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09402", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09402", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847631", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847631", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S005", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S005", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S005-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S005-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQH0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIJ4", "url": "https://www.uniprot.org/uniprotkb/E1BIJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIJ4-1", "url": "https://www.uniprot.org/uniprotkb/E1BIJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQESKKNLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCNTPLKPSNKHMNSMSHLRLRTGLANSQGGS", "length": 913, "header": "tr|A0AAA9TCE5-1|A0AAA9TCE5_BOVIN Isoform 1 of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=1 CANONICAL=A0AAA9TCE5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S005-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5/entry#A0AAA9S005-1", "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQESKKNLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGNWLQ", "length": 838, "header": "tr|A0AAA9S005-1|A0AAA9TCE5_BOVIN Computationally mapped isoform of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=1 CANONICAL=A0AAA9TCE5-1" }, "locus": { "chromosome": "5", "start_pos": 48614389, "end_pos": 48543009, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106953.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106953.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076665.1" } ] } }, { "isoform_ac": "A0AAA9SEG6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5/entry#A0AAA9SEG6-1", "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQESKKNLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREVYSKMIQLYKPVNPKGNNS", "length": 852, "header": "tr|A0AAA9SEG6-1|A0AAA9TCE5_BOVIN Computationally mapped isoform of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=1 CANONICAL=A0AAA9TCE5-1" }, "locus": { "chromosome": "5", "start_pos": 48614389, "end_pos": 48538933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113121.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113121.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082242.1" } ] } }, { "isoform_ac": "A0AAA9TCE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5/entry#A0AAA9TCE5-1", "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQESKKNLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCNTPLKPSNKHMNSMSHLRLRTGLANSQGGS", "length": 913, "header": "tr|A0AAA9TCE5-1|A0AAA9TCE5_BOVIN Isoform 1 of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=1 CANONICAL=A0AAA9TCE5-1" }, "locus": { "chromosome": "5", "start_pos": 48614389, "end_pos": 48542863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114723.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114723.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093788.1" } ] } }, { "isoform_ac": "A0AAA9TQH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5/entry#A0AAA9TQH0-1", "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGKLVTVKYLRLDRYHHRFPQALTCNTPLKPSNKHMNSMSHLRLRTGLANSQGGS", "length": 868, "header": "tr|A0AAA9TQH0-1|A0AAA9TQH0_BOVIN Computationally mapped isoform of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=1 CANONICAL=A0AAA9TCE5-1" }, "locus": { "chromosome": "5", "start_pos": 48614389, "end_pos": 48542863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088731.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088731.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098662.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098662.1" } ] } }, { "isoform_ac": "E1BIJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5/entry#E1BIJ4-1", "sequence": { "sequence": "MAAAAASAPQQLSDEELFSQLRRYGLSPGPVTESTRPVYLKKLKKLREEEQQQHRSGGRGTKTRNSNNNNTAAATVAAAGPAAAAVGMGVRPVSGDLSFLRTPGGLGRVSASGPETPLGGPGGASATLTAGSKVLLGFSSDESDVEASPRDQAGGGGGRKDRAPLQYRGLKPPSAPLAASEVTNSNSAERRKPHSWWGARRPAAPELQSPSGRDGAADDEEQEGEDGEDRDPEAEEPLWSGRTVNGSRLLPYSCRENYSDSEEEEDDDVASSRQVLKDDTLSRHRPRRGHSKPLSPLPAKSAGGRLETSVQGGGGIAMNDRAAAAGSLDRSRNLEESAAAAAEQGGGCDPLDSSPIPRYRVNAKKLTPLLPPPLADMDSTLDSSTGSLLKTNNHIGGGAFGVDSPRIFPNSLPPSAAVAASSSLRINHSNHTGSNHTYLKNTYNKPKLSEPEEELLQQFKREEVSPTGGFSAHYLSMFLLTAACLFFLILGLTYLGMRGTGVSEDGGLGIKNPFDETFGDMQESKKNLMMNTLYKLHDRLAQLAGDHECGSSSQRTLSVQEAAAYLKDLGPEYEDTFNISLKWIFENGKDVGIRCVGYGPEEELTDIVDVQFLQSTRPQMSFWCRFRRAFVTVTHRLLLLCLGVVMVCVVLRYMKYRWTKEEEETRQMYDMVVKIIDVLRSHNEACQENKDLQPYMPIPHVRDSLIQPHDRKKMKKVWDRAVDFLAANESRVRTETRRIGGADFLVWRWIQPSASCDKILVIPSKVWQGQAFHLDRRNSPPNSLTPCLKIRNMFDPVMEIGDQWHLAIQEAILEKCSDNDGIVHIAVDKNSREGCVYVKCLSPEYAGKAFKALHGSWFDGVQQNDSVIQTSQS", "length": 873, "header": "tr|E1BIJ4-1|E1BIJ4_BOVIN Computationally mapped isoform of Inner nuclear membrane protein Man1 OS=Bos taurus OX=9913 GN=LEMD3 PE=4 SV=4 CANONICAL=A0AAA9TCE5-1" }, "locus": { "chromosome": "5", "start_pos": 48614389, "end_pos": 48538949, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053178.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053178.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047700.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047700.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 467, "start_aa": "Thr", "end_pos": 467, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr467", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" }, { "name": "negative regulation of activin receptor signaling pathway", "id": "GO:0032926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032926", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" }, { "name": "nuclear envelope organization", "id": "GO:0006998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006998", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 427, "end_pos": 429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCE5" }, { "id": "PS50954", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50954" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LEM", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 50, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 467 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 245, "end_pos": 247 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 427, "end_pos": 429 }, { "start_pos": 430, "end_pos": 432 }, { "start_pos": 435, "end_pos": 437 }, { "start_pos": 578, "end_pos": 580 }, { "start_pos": 69, "end_pos": 71 }, { "start_pos": 728, "end_pos": 730 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAH2-1", "uniprot_ac": "A0AAA9TAH2", "uniprot_id": "A0AAA9TAH2_BOVIN", "mass": { "chemical_mass": 82042.0, "monoisotopic_mass": 82042.0 }, "refseq": {}, "gene_names": [ { "name": "PUM3", "type": "recommended", "evidence": [ { "id": "A0AAA9TAH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ] } ], "protein_names": [ { "name": "Pumilio homolog 3", "type": "recommended", "evidence": [ { "id": "A0AAA9TAH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S018", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S018#function" }, { "database": "UniProtKB", "id": "ARBA00055542", "url": "https://www.uniprot.org/uniprotkb/ARBA00055542#function" }, { "database": "UniProtKB", "id": "A0AAA9T2X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X3#function" }, { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2#function" }, { "database": "UniProtKB", "id": "F6QTI1", "url": "https://www.uniprot.org/uniprotkb/F6QTI1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PUM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2", "locus": { "chromosome": "8", "start_pos": 41778313, "end_pos": 41634705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013357", "url": "https://www.ensembl.org/id/ENSBTAG00000013357" } ] } } ], "crossref": [ { "id": "A0AAA9TAH2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR001313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13389", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13389", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13389:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13389:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S018", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S018", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S018-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S018-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QTI1", "url": "https://www.uniprot.org/uniprotkb/F6QTI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QTI1-1", "url": "https://www.uniprot.org/uniprotkb/F6QTI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRRGPVEMPNFRFSGYCQPLNSSSAEEEEERLGGGARRGSGSRSGGAGTRACQGHTCAVSEGGLGGASGGPSSLPGAGVGGFLRVAIMEVKGKKKLTGKGTKMSQEKSKFHKNNDSGSSKTFPKKVVKEGGPKITSKNFEKTATKPGKKGVKQFKNKQQGDRIPKNKFQQANKFNQKRKFQPDSKSDESAAKKPKWDEFKKKKKELKQSRQLSDKTNYDIVIRAKQIWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQFGNEEQRKQAFEELRGDLVELSKAKYSRNIVKKFLMYGSKAQIAEIIRSFKGHVRKLLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMYCLWHGTPKDRKVIVKTMKTYIEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIINSLPNIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEIRRRELLESISPALLSYLQGHAQEVVLDKSACVLVADILGTATGDVQPAMDAVASLAAAELHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKERGREGCFAKTLIERVGVKNLKSWASVNRGAIILSSLLQSSDQEVANKVKAGLKSLIPALEKSKNTSKGIEMLLEKLTA", "length": 735, "header": "tr|A0AAA9TAH2-1|A0AAA9TAH2_BOVIN Isoform 1 of Pumilio homolog 3 OS=Bos taurus OX=9913 GN=PUM3 PE=4 SV=1 CANONICAL=A0AAA9TAH2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S018-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2/entry#A0AAA9S018-1", "sequence": { "sequence": "MAFHLELQVSDFPAFIIIVAIMEVKGKKKLTGKGTKMSQEKSKFHKNNDSGSSKTFPKKVVKEGGPKITSKNFEKTATKPGKKGVKQFKNKQQGDRIPKNKFQQANKFNQKRKFQPDSKSDESAAKKPKWDEFKKKKKELKQSRQLSDKTNYDIVIRAKQIWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQFGNEEQRKQAFEELRGDLVELSKAKYSRNIVKKFLMYGSKAQIAEIIRSFKGHVRKLLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMYCLWHGTPKDRKVIVKTMKTYIEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIINSLPNIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEIRRRELLESISPALLSYLQGHAQEVVLDKSACVLVADILGTATGDVQPAMDAVASLAAAELHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKERGREGCFAKTLIERVGVKNLKSWASVNRGAIILSSLLQSSDQEVANKVKAGLKSLIPALEKSKNTSKGIEMLLEKLTA", "length": 668, "header": "tr|A0AAA9S018-1|A0AAA9TAH2_BOVIN Computationally mapped isoform of Pumilio homolog 3 OS=Bos taurus OX=9913 GN=PUM3 PE=4 SV=1 CANONICAL=A0AAA9TAH2-1" }, "locus": { "chromosome": "8", "start_pos": 41696162, "end_pos": 41637423, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127726.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127726.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076680.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076680.1" } ] } }, { "isoform_ac": "A0AAA9T2X3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2/entry#A0AAA9T2X3-1", "sequence": { "sequence": "MEVKGKKKLTGKGTKMSQEKSKFHKNNDSGSSKTFPKKVVKEGGPKITSKNFEKTATKPGKKGVKQFKNKQQGDRIPKNKFQQANKFNQKRKFQPDSKSDESAAKKPKWDEFKKKKKELKQSRQLSDKTNYDIVIRAKQIWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQFGNEEQRKQAFEELRGDLVELSKAKYSRNIVKKFLMYGSKAQIAEIIRSFKGHVRKLLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMYCLWHGTPKDRKVIVKTMKTYIEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIINSLPNIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEIRRRELLESISPALLSYLQGHAQEVVLDKSACVLVADILGTATGDVQPAMDAVASLAAAELHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKERGREGCFAKTLIERVGVKNLKSWASVNRGAIILSS", "length": 604, "header": "tr|A0AAA9T2X3-1|A0AAA9TAH2_BOVIN Computationally mapped isoform of Pumilio homolog 3 OS=Bos taurus OX=9913 GN=PUM3 PE=4 SV=1 CANONICAL=A0AAA9TAH2-1" }, "locus": { "chromosome": "8", "start_pos": 41778244, "end_pos": 41659328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093104.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093104.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092086.1" } ] } }, { "isoform_ac": "A0AAA9TAH2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2/entry#A0AAA9TAH2-1", "sequence": { "sequence": "MTRRGPVEMPNFRFSGYCQPLNSSSAEEEEERLGGGARRGSGSRSGGAGTRACQGHTCAVSEGGLGGASGGPSSLPGAGVGGFLRVAIMEVKGKKKLTGKGTKMSQEKSKFHKNNDSGSSKTFPKKVVKEGGPKITSKNFEKTATKPGKKGVKQFKNKQQGDRIPKNKFQQANKFNQKRKFQPDSKSDESAAKKPKWDEFKKKKKELKQSRQLSDKTNYDIVIRAKQIWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQFGNEEQRKQAFEELRGDLVELSKAKYSRNIVKKFLMYGSKAQIAEIIRSFKGHVRKLLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMYCLWHGTPKDRKVIVKTMKTYIEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIINSLPNIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEIRRRELLESISPALLSYLQGHAQEVVLDKSACVLVADILGTATGDVQPAMDAVASLAAAELHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKERGREGCFAKTLIERVGVKNLKSWASVNRGAIILSSLLQSSDQEVANKVKAGLKSLIPALEKSKNTSKGIEMLLEKLTA", "length": 735, "header": "tr|A0AAA9TAH2-1|A0AAA9TAH2_BOVIN Isoform 1 of Pumilio homolog 3 OS=Bos taurus OX=9913 GN=PUM3 PE=4 SV=1 CANONICAL=A0AAA9TAH2-1" }, "locus": { "chromosome": "8", "start_pos": 41696162, "end_pos": 41654898, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128458.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128458.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093630.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093630.1" } ] } }, { "isoform_ac": "F6QTI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2/entry#F6QTI1-1", "sequence": { "sequence": "MEVKGKKKLTGKGTKMSQEKSKFHKNNDSGSSKTFPKKVVKEGGPKITSKNFEKTATKPGKKGVKQFKNKQQGDRIPKNKFQQANKFNQKRKFQPDSKSDESAAKKPKWDEFKKKKKELKQSRQLSDKTNYDIVIRAKQIWEILRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCYIQFGNEEQRKQAFEELRGDLVELSKAKYSRNIVKKFLMYGSKAQIAEIIRSFKGHVRKLLRHAEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLEVQPEKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSEMIEAIREAVVYLAHTHDGARVAMYCLWHGTPKDRKVIVKTMKTYIEKVANEIINSLPNIVNDKYGRKVLLYLLSPRDPAHTVREIIEVLQKGDGNAHSKKDTEIRRRELLESISPALLSYLQGHAQEVVLDKSACVLVADILGTATGDVQPAMDAVASLAAAELHPGGKDGELHIAEHPAGHLVLKWLIEQDKKMKERGREGCFAKTLIERVGVKNLKSWASVNRGAIILSSLLQSSDQEVANKVKAGLKSLIPALEKSKNTSKGIEMLLEKLTA", "length": 620, "header": "tr|F6QTI1-1|F6QTI1_BOVIN Computationally mapped isoform of Pumilio homolog 3 OS=Bos taurus OX=9913 GN=PUM3 PE=4 SV=1 CANONICAL=A0AAA9TAH2-1" }, "locus": { "chromosome": "8", "start_pos": 41696162, "end_pos": 41659328, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017765.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017765.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017765.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017765.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAH2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAH2" } ], "pmid": "" }, { "name": 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"Cricetulus griseus", "sequence": { "sequence": "MNPWLFACLVACFVGAWVPVVHVQGAFEDCCLGYQPRIKWNILQRARHYQWQEVSGSCNLRAVIFYFHHKGPVCMNPKDKDVKIAMRILSTKNKTVDNPQKSNTGSHTVRKKSNHAKSKMGNPSNNSARNATLGRSRMAMMNRKINN", "length": 147 }, "evidence": [ { "id": "A0AAA9TD41", "url": "https://omabrowser.org/oma/group/A0AAA9TD41/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15444-1", "protein_name": "C-C motif chemokine 25", "gene_name": "CCL25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL", "length": 150 }, "evidence": [ { "id": "A0AAA9TD41", "url": "https://omabrowser.org/oma/group/A0AAA9TD41/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35903-1", "protein_name": "C-C motif chemokine 25", "gene_name": "Ccl25", 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"id": "A0AAA9TD41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TD41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD41" }, { "id": "SM00199", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00199" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Chemokine interleukin-8-like", "eco_id": "ECO_0000259", "start_pos": 144, "end_pos": 207, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDW6-1", "uniprot_ac": "A0AAA9TDW6", "uniprot_id": "A0AAA9TDW6_BOVIN", "mass": { "chemical_mass": 75483.0, "monoisotopic_mass": 75483.0 }, "refseq": { "ac": "XP_024833195", "name": "microtubule-associated protein 9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833195" }, "gene_names": [ { "name": "MAP9", "type": "recommended", "evidence": [ { "id": "A0AAA9TDW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ] }, { "name": "MAP9", "type": "synonym", "evidence": [ { "id": "XP_024833195", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833195" } ] } ], "protein_names": [ { "name": "Microtubule associated protein 9", "type": "synonym", "evidence": [ { "id": "A0AAA9TDW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6/entry#names_and_taxonomy" } ] }, { "name": "microtubule-associated protein 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024833195", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833195" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6", "locus": { "chromosome": "17", "start_pos": 1978084, "end_pos": 1931202, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019053", "url": "https://www.ensembl.org/id/ENSBTAG00000019053" } ] } } ], "crossref": [ { "id": "A0AAA9TDW6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613821", "url": "https://www.ncbi.nlm.nih.gov/gene/613821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613821", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YENWLVR", "url": "https://omabrowser.org/oma/group/YENWLVR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI78", "url": "https://www.orthodb.org/?gene=F1MI78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14739:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14739:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024833195", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833195", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Y1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S934", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S934", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S934-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S934-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI78", "url": "https://www.uniprot.org/uniprotkb/F1MI78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI78-1", "url": "https://www.uniprot.org/uniprotkb/F1MI78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIKAITARSARQRSSEYSDDFDSDEIGDFSDTSVDENSVNKKMNNFHISDDEENNSPKLSFLKTKKSSNDVRKHEPIVSIKNDDIAFDNGEGMVVNPLPESQNKQQEVEKEKIKMETKPRILPIKSTSSENNSSLEADSQFKPSPRPRSMLKKHSHGEKKDSLGNNKETVPHEDLEGHSTPSFLPRPNDRQPEAERNAFSENLDPEDPWLTSIPSSSVKENLKDSFSLGSEEKASITVDQNEECTESHNSLKSTENEKNSFLIDFVTTALEKPKESQVTVGDVEEEKEKAHLIMNDDLTAEDTPLLQLQSILCTESSKKAIQDRNMKNKKSTNNRASSASGRLMTSEFLKKPSSLRRIPSTASASHYLGTLRVLDQKPSQKQNTEPDRADNLRATVYQEWLEKKNIYLHEMHRIKRIESENLRIQNEQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKAKKMEYLKEKNKKEKEYERAKKQKEEETVAEKRKDNLTAVEKWNEKKEVFFKEKEKVKIHEKRKEEQKRAEKKEKDKQALEEYEKWLPTRLLCPWDSPGKDAGVGCHALLHGIFVTQGSNPCRFRLLHCQAGSLPLAPPWEA", "length": 657, "header": "tr|A0AAA9TDW6-1|A0AAA9TDW6_BOVIN Isoform 1 of Microtubule associated protein 9 OS=Bos taurus OX=9913 GN=MAP9 PE=4 SV=2 CANONICAL=A0AAA9TDW6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6/entry#A0AAA9S3Y1-1", "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIKAITARSARQRSSEYSDDFDSDEIGDFSDTSVDENSVNKKMNNFHISDDEENNSPKLSFLKTKKSSNDVRKHEPIVSIKNDDIAFDNGEGMVVNPLPESQNKQQEVEKEKIKMETKPRILPIKSTSSENNSSLEADSQFKPSPRPRSMLKKHSHGEKKDSLGNNKETVPHEDLEGHSTPSFLPRPNDRQPEAERNAFSENLDPEDPWLTSIPSSSVKENLKDSFSLGSEEKASITDQNEECTESHNSLKSTENEKNSFLIDFVTTALEKPKESQVTVGDVEEEKEKAHLIMNDDLTAEDTPLLQLQSILCTESSKKAIQDRNMKNKKSTNNRASSASGRLMTSEFLKKPSSLRRIPSTASASHYLGTLRVLDQKPSQKQNTEPDRADNLRATVYQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKAKKMEYLKEKNKKEKEYERAKKQKEEETVAEKRKDNLTAVEKWNEKKEVFFKEKEKVKIHEKRKEEQKRAEKKEKDKQALEEYEKWLPTRLLCPWDSPGKDAGVGCHALLHGIFVTQGSNPCRFRLLHCQAGSLPLAPPWEA", "length": 626, "header": "tr|A0AAA9S3Y1-1|A0AAA9TDW6_BOVIN Computationally mapped isoform of Microtubule associated protein 9 OS=Bos taurus OX=9913 GN=MAP9 PE=4 SV=1 CANONICAL=A0AAA9TDW6-1" }, "locus": { "chromosome": "17", "start_pos": 1960568, "end_pos": 1932500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121614.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121614.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076827.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076827.1" } ] } }, { "isoform_ac": "A0AAA9S934-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6/entry#A0AAA9S934-1", "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIKAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSVDENSVNKKMNNFHISDDEENNSPKLSFLKTKKSSNDVRKHEPIVSIKNDDIAFDNGEGMVVNPLPESQNKQQEVEKEKIKMETKPRILPIKSTSSENNSSLEADSQFKPSPRPRSMLKKHSHGEKKDSLGNNKETVPHEDLEGHSTPSFLPRPNDRQPEAERNAFSENLDPEDPWLTSIPSSSVKENLKDSFSLGSEEKASITDQNEECTESHNSLKSTENEKNSFLIDFVTTALEKPKESQVTVGDVEEEKEKAHLIMNDDLTAEDTPLLQLQSILCTESSKKAIQDRNMKNKKSTNNRASSASGRLMTSEFLKKPSSLRRIPSTASASHYLGTLRVLDQKPSQKQNTEPDRADNLRATVYQEWLEKKNIYLHEMHRIKRIESENLRIQNEQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKAKKMEYLKEKNKKEKEYERAKKQKEEETVAEKRKDNLTAVEKWNEKKEVFFKEKEKVKIHEKRKEEQKRAEKKEKDKQALEEYEKWLEKKERKERIERKQKKHHPFLENETLPPWSPPSRTVFSKVF", "length": 644, "header": "tr|A0AAA9S934-1|A0AAA9TDW6_BOVIN Computationally mapped isoform of Microtubule associated protein 9 OS=Bos taurus OX=9913 GN=MAP9 PE=4 SV=1 CANONICAL=A0AAA9TDW6-1" }, "locus": { "chromosome": "17", "start_pos": 1977080, "end_pos": 1932500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098626.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098626.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082579.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082579.1" } ] } }, { "isoform_ac": "A0AAA9TDW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6/entry#A0AAA9TDW6-1", "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIKAITARSARQRSSEYSDDFDSDEIGDFSDTSVDENSVNKKMNNFHISDDEENNSPKLSFLKTKKSSNDVRKHEPIVSIKNDDIAFDNGEGMVVNPLPESQNKQQEVEKEKIKMETKPRILPIKSTSSENNSSLEADSQFKPSPRPRSMLKKHSHGEKKDSLGNNKETVPHEDLEGHSTPSFLPRPNDRQPEAERNAFSENLDPEDPWLTSIPSSSVKENLKDSFSLGSEEKASITVDQNEECTESHNSLKSTENEKNSFLIDFVTTALEKPKESQVTVGDVEEEKEKAHLIMNDDLTAEDTPLLQLQSILCTESSKKAIQDRNMKNKKSTNNRASSASGRLMTSEFLKKPSSLRRIPSTASASHYLGTLRVLDQKPSQKQNTEPDRADNLRATVYQEWLEKKNIYLHEMHRIKRIESENLRIQNEQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKAKKMEYLKEKNKKEKEYERAKKQKEEETVAEKRKDNLTAVEKWNEKKEVFFKEKEKVKIHEKRKEEQKRAEKKEKDKQALEEYEKWLPTRLLCPWDSPGKDAGVGCHALLHGIFVTQGSNPCRFRLLHCQAGSLPLAPPWEA", "length": 657, "header": "tr|A0AAA9TDW6-1|A0AAA9TDW6_BOVIN Isoform 1 of Microtubule associated protein 9 OS=Bos taurus OX=9913 GN=MAP9 PE=4 SV=2 CANONICAL=A0AAA9TDW6-1" }, "locus": { "chromosome": "17", "start_pos": 1960568, "end_pos": 1932500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096319.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096319.2" } ] } }, { "isoform_ac": "F1MI78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6/entry#F1MI78-1", "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIKAITARSARQRSSEYSDDFDSDEIGDFSDTSVDENSVNKKMNNFHISDDEENNSPKLSFLKTKKSSNDVRKHEPIVSIKNDDIAFDNGEGMVVNPLPESQNKQQEVEKEKIKMETKPRILPIKSTSSENNSSLEADSQFKPSPRPRSMLKKHSHGEKKDSLGNNKETVPHEDLEGHSTPSFLPRPNDRQPEAERNAFSENLDPEDPWLTSIPSSSVKENLKDSFSLGSEEKASITVDQNEECTESHNSLKSTENEKNSFLIDFVTTALEKPKESQVTVGDVEEEKEKAHLIMNDDLTAEDTPLLQLQSILCTESSKKAIQDRNMKNKKSTNNRASSASGRLMTSEFLKKPSSLRRIPSTASASHYLGTLRVLDQKPSQKQNTEPDRADNLRATVYQEWLEKKNIYLHEMHRIKRIESENLRIQNEQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKAKKMEYLKEKNKKEKEYERAKKQKEEETVAEKRKDNLTAVEKWNEKKEVFFKEKEKVKIHEKRKEEQKRAEKKEKDKQALEEYEKWLACIWRFLTFKHKESDVYSSIVFVWEENIRTSCLQD", "length": 637, "header": "tr|F1MI78-1|A0AAA9TDW6_BOVIN Computationally mapped isoform of Microtubule associated protein 9 OS=Bos taurus OX=9913 GN=MAP9 PE=4 SV=4 CANONICAL=A0AAA9TDW6-1" }, "locus": { "chromosome": "17", "start_pos": 1973716, "end_pos": 1932500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025362.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025362.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025362.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025362.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613821", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IQ91-1", "protein_name": "Microtubule-associated protein 9", "gene_name": "Map9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDEIFSTTLAYTKSPKATKRTSFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGEFSDTSTDESLVRKKVNDFHISDDEEKSSPRLSFLKTKKVNSDVAKDGQESVTQISEDMSPDVHDDPKSQNDDQEVGKEITEIKAKPRVLPIKKSTSSGENSSSHEADDHFKPSPRPRSIKKSIPMEEGDRPDDKKQSPSEDSATMPSLPRQNGTELETEEKVHSENLDLEDSLLQSLTSSSIKESPANCTSPGSQEKISIKDHDGEPTEIWDSLISNENEENSVLVNCVTPEVELPKTSQVTADDTEEEKEKAGFTDDDFTTDPLLSTSPSVITPTETAEPAKKTNEERNMKNKKPTNNRVSSASGRLMTSEFLKKSGPTRRSPSAATSSHYLGTLKVLDKKPSRKQSIETDKADHIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKRAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKRKTEEENAVRKSEALQAFEKWKEKKLEYLKEKTRKEKEYERAKKQKEEETVAEKKKDNLTAFEKWSEKKEALLKQKEKEKINERRKEELKRAEKKDKDQQAISEYEKWLEKKERQERVDRKQKKRHSYLESETHPPWSPPSRTVPSKVL", "length": 638 }, "evidence": [ { "id": "A0AAA9TDW6", "url": "https://omabrowser.org/oma/group/A0AAA9TDW6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZAG3-1", "protein_name": "Microtubule-associated protein 9", "gene_name": "Map9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDEIFSTTLAYTKSPKATKRTSFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGEFSDTSTDESLIRKKMNDFHMSDDEEKNSPRLSFLKTKKVNSEISKDDLDSVILDSEGTSPDAQEDMTGNSTPKSQNDDQDVGREVITMKPTPRMLPGKRSTSSGENSSSLDTDGHFKPSPRPRSMLKKSWHPEEGVRSGVDKEYSTTEDSAPTPSLPRQNGTELQTEEKVCSENLDLEDSLLQSLTSSSLKESPGGCISPGSQEKTPIKDHDGEPTEIWDSLISNENEGSSILVNCVTPELEQPKEGQVAADNLEEEREKGGFTEDDLTTDPLLSTSPSVITPTEPAEPAKKTNEVKTTKNKKTTNNRVSSASGRLMTSEFLKRSGPTKRSPSAATSSHYLGSLKVLDQKPPRKQSLEPDKADHIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAVRKGEALQAFEKWKEKKLEYLKEKTRREKESERAKKQKEEEAVAEKKKDSVTAFERWSEKKEALLKQKEKEKINERRKEELKRAEKKDKDKQAISEYEKWLEKKERQERIDRKQKKRHSFLESETHPPWSPPSRTAPSKVF", "length": 646 }, "evidence": [ { "id": "A0AAA9TDW6", "url": "https://omabrowser.org/oma/group/A0AAA9TDW6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TRR0-1", "protein_name": "Microtubule-associated protein 9", "gene_name": "Map9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDEIFSTTLAYTKSPKATKRTSFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGEFSDTSTDESLVRKKMNDFHISDDEEKNSPRLSFLKTKKVNRAISNDALDSSTPGSEGSSPDAQEDVTGDSLPKSQNDDREVGREIITVKPTPRMHPVKRSTSSGETSSGLDADGHFKPSPQPRSMLKKSSHTEEGVRPGVDKEHSISEASAPTPSLPRQNGTELQTEEKIYSENLDLEDSLLQSLTSSSFKESPGGCTSPGSQEKVPIKDHDGEPTEIWDSLLSNENEGSSVLVNCVTPELEQPKDGQVAADDLEEEREKGGFTEDDLTTDPLLSTSPSVITPTEPAEPAKKANEDRNTKNKKTTNNRVSSASGRLMTSEFLKRSGPTKRSPSAATSSHYLGSLKVLDQKQPRKQSLEPDKADHIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKRIAAKKRLEEKNKKKTEEENAMRKGEALQAFEKWKEKKLEYLKEKTRREKEYERAKKQKEEEAVAEKKKDSLTAFEKWSERKEALLKQKEKEKINERRKEELKRAEKKDKDKQAISEYEKWLEKKERQERIERKQKKRHSFLESETHPPWSPPSRTAPSKVF", "length": 646 }, "evidence": [ { "id": "A0AAA9TDW6", "url": "https://omabrowser.org/oma/group/A0AAA9TDW6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q49MG5-1", "protein_name": "Microtubule-associated protein 9", "gene_name": "MAP9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEYSDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNITKDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSSAENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPNGIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITENHNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPSTTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWSPPSRTVFAKVF", "length": 647 }, "evidence": [ { "id": "A0AAA9TDW6", "url": "https://omabrowser.org/oma/group/A0AAA9TDW6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "spindle assembly", "id": "GO:0051225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "regulation of mitotic centrosome separation", "id": "GO:0046602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046602", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "mitotic spindle assembly", "id": "GO:0090307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "regulation of mitotic spindle organization", "id": "GO:0060236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "regulation of mitotic cytokinesis", "id": "GO:1902412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902412", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "astral microtubule", "id": "GO:0000235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000235", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "spindle midzone", "id": "GO:0051233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 551, "end_pos": 553 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TCM6-1", "uniprot_ac": "A0AAA9TCM6", "uniprot_id": "A0AAA9TCM6_BOVIN", "mass": { "chemical_mass": 83183.0, "monoisotopic_mass": 83183.0 }, "refseq": { "ac": "XP_002689991", "name": "sushi domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689991" }, "gene_names": [ { "name": "SUSD1", "type": "recommended", "evidence": [ { "id": "A0AAA9TCM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" } ] }, { "name": "SUSD1", "type": "synonym", "evidence": [ { "id": "XP_002689991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689991" } ] } ], "protein_names": [ { "name": "Sushi domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TCM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#names_and_taxonomy" } ] }, { "name": "sushi domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002689991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689991" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUSD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6", "locus": { "chromosome": "8", "start_pos": 101441192, "end_pos": 101594748, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004813", "url": "https://www.ensembl.org/id/ENSBTAG00000004813" } ] } } ], "crossref": [ { "id": "A0AAA9TCM6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004813", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004813", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518850", "url": "https://www.ncbi.nlm.nih.gov/gene/518850", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518850", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518850", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCLRWQI", "url": "https://omabrowser.org/oma/group/TCLRWQI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQ74", "url": "https://www.orthodb.org/?gene=F1MQ74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24051:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24051:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689991", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S681", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S681", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S681-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S681-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFV9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4B6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4B6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4B6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4B6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ74", "url": "https://www.uniprot.org/uniprotkb/F1MQ74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ74-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKGSSLTFLLPQMVGVGLGSMAVVIVLAFLSFSAV", "length": 753, "header": "tr|A0AAA9TCM6-1|A0AAA9TCM6_BOVIN Isoform 1 of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S681-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9S681-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKGGFFTTEPPRKTICCDNPKNWP", "length": 742, "header": "tr|A0AAA9S681-1|A0AAA9TCM6_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101441326, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122167.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122167.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079354.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079354.1" } ] } }, { "isoform_ac": "A0AAA9SFV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9SFV9-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKVAVLSCPVMSDSLRPHGL", "length": 738, "header": "tr|A0AAA9SFV9-1|A0AAA9TCM6_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101467600, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112968.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112968.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084257.1" } ] } }, { "isoform_ac": "A0AAA9SWG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9SWG8-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNETAACQAPLSSTVSQSLLQFMSIELVMLS", "length": 695, "header": "tr|A0AAA9SWG8-1|A0AAA9TCM6_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101479770, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097919.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097919.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087575.1" } ] } }, { "isoform_ac": "A0AAA9T4B6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9T4B6-1", "sequence": { "sequence": "MWLWSCALTQFLSPPLSPDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKGSSLTFLLPQMVGVGLGSMAVVIVLAFLSFSAV", "length": 735, "header": "tr|A0AAA9T4B6-1|A0AAA9TCM6_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101584817, "end_pos": 101464652, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094128.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094128.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092639.1" } ] } }, { "isoform_ac": "A0AAA9T9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9T9R8-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNETAACQAPLSSTVSQSLLQFMSIELVMLS", "length": 735, "header": "tr|A0AAA9T9R8-1|A0AAA9T9R8_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101479770, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093619.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093619.1" } ] } }, { "isoform_ac": "A0AAA9TCM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9TCM6-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKGSSLTFLLPQMVGVGLGSMAVVIVLAFLSFSAV", "length": 753, "header": "tr|A0AAA9TCM6-1|A0AAA9TCM6_BOVIN Isoform 1 of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101464652, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125405.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125405.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095808.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095808.1" } ] } }, { "isoform_ac": "A0AAA9TRF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#A0AAA9TRF2-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTGFKSSSGAVADIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVRRSACAVWAHVKGSSLTFLLPQMVGVGLGSMAVVIVLAFLSFSAV", "length": 763, "header": "tr|A0AAA9TRF2-1|A0AAA9TRF2_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=1 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101464652, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090094.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090094.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099606.1" } ] } }, { "isoform_ac": "F1MQ74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6/entry#F1MQ74-1", "sequence": { "sequence": "MARGPWGVGIPLGRLLLPLLLPLNLARGAPRAWSQDDFHSDICATCHEHATCLKRETTSICICKYGFVGNGRTHCIDKDECQYGASVVCGNHTSCHNIPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSSRCRRGGRCVNTRGSYECYCMDGYLPKGGPEPFHPTRDATSCTEIDCGTPPEIPGGYIIGNYTSRLGSQVHYACKEGFFSDSEDTASSCTAMGTWESPKLNCQEIDCGRPPEVQHAILEGNHSSRLGSVAHYVCLEGFESPGGKITSVCTEKGTWRTSASTCSEIIIEINEVSVFNNTCVRWQINPGRINSKIEYVIYIKGQRLDPLESGHEETVNLTTESRTPEVCLDLYPGTNYTVNISTAPPRRSVPAVTEFQTAGDDLLEDDGIFNISIFNEVCLKLNRHSRKVGSERVYQFKVLGRRWYLNTFYHATSFNFTTREQTAVVCLDLYPATDYSVNVTLLGSPERPSVQTTVTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLVHIWGQRWYQKGFAQEMIFNITASSQTPETCLDLSPGTNYSVSIQALSSELPVVISLTTQITEPPLPEVDFFTVHGGPLPRLRLRKATEKNGPISSYQVLVLPSALQSTFACDSEEVASFFSEASEASGYVTAELLAKDIPDDAMEIPIGDRLYYGKYYNAPLKTGHDYCIILRITSEWNEVHHSHSCCRRWWALGWAPWLS", "length": 728, "header": "tr|F1MQ74-1|A0AAA9TCM6_BOVIN Computationally mapped isoform of Sushi domain containing 1 OS=Bos taurus OX=9913 GN=SUSD1 PE=4 SV=4 CANONICAL=A0AAA9TCM6-1" }, "locus": { "chromosome": "8", "start_pos": 101594549, "end_pos": 101464689, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043830.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043830.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041372.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041372.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518850", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518850", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTG3-1", "protein_name": "Sushi domain containing 1", "gene_name": "Susd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQGPRGTRRSPGCGLQRLLWLLLLLSLARGASGEPGTDDVCATCHEHATCQQKEGKRICICNYGFWGNGRTRCVDKDECQFGATVICGNHTSCHNTPGGFYCVCHTGYRATNNKKMFIPNDGTFCADVDECEDSGLCRRGGRCINTPGSFECYCMEGYVAKNGSEPFHPHADATSCTEIDCGIPPEVPGAYIVGSYSSTLGGQAHYSCKEGFLSISGDRVSRCTALGAWEPPELLCQEISCGSPPEVQNAILVGNHSSSQGSVAHYDCEEGFESPGGKITSVCTDSGSWSEITYACAEIAMVIHDVWVFNDTCVRWQRSPERVNSKVTYLIHTERLQPDAVESVYEETINVTTDSKTPEVCLHLQQGANYTVSISAAPPRRSVPASLSFQTAEDGLLEDDGIFNISVFNETCLKLNRHSRQAGSEQMYQVEALGQRWYLENFYHAVSYNFTTRDQAPKLCLDLLPATDYMINITLLRPTELRSAQVTVTTSATAKQPIDLSVCNDICLRQSSLKSVGAAEMYLFHVWGQRYQKAFVQEMVLNASNSQDPEICLDPHGGTSYNVSFQALSSALPVVIYLTTLITEPPLPEVDFFTVRGRLLPSFRLRKAKEINGPISSYQVLVLPLSLQSTFSCDSEGITSFFGNASPADGYVAAEILASDVPDDTLEISIGDRLYYGEYYNAPLKTVNEYCILLRITSEWNKVRRYSCAVMAEVKDSSLTVQQMVGVGLGSVAFVTILAFLSFSAV", "length": 747 }, "evidence": [ { "id": "A0AAA9TCM6", "url": "https://omabrowser.org/oma/group/A0AAA9TCM6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XS79-1", "protein_name": "Sushi domain containing 1", "gene_name": "SUSD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAGRGRALGPPPLLLLLLALPPGAGLPVSDVCATCHVHATCHQIEGKSACICNYGFVGNGRTHCQDKDECQIGASKICGNHTLCHNTHGSFYCVCLDGFRASNNNKIFIPNDGTNCTDIDECEEAGLCGYNARCVNTEGSYECYCNDGYKLENGERSFHPNASSASCKEIRCGSPPEMKHGYIVGNYSLVPGSTVHYECKEGFYSNEGKSSYCTAEKAWEPATLSCKVVDCGVPPAILNAHQASLSGTAYGSEVTYSCIHGYFIASGNQTAVCNAKGQWDGADLMCKEIDCGRPLLIPHTEIIWDNSTTLLSRVFYKCKEGYYFNGERNFSECTLDQKWESITYICKEEELFSNLTVFNETCVTWQMRTGRLGVQKTYTFHILGRRWDEKTFSEDVILNITTSEDNPKVCLDLNSGSNYVVNITTISSTNMPVSVTVAVQTKVKEAFNNVLIFNDTCLKWRRSVRGADMEDRYLFHVQGQRWYQKEFLHEMTFDLTTRKQAPEVCFDLQPGTNYSINISMVALNFSLLVSMTTQITDPPFPDIEFVAAKGSAPLLRLRKAEDRNGPISLYQVIVLPLGLQSTFVCDSFATATFFSNTTDAKGYVAAEFRARDVADNMSVALGDRHYYGKFYNAPLKLGKEYCVFLRIISEWNKVRTQSCVVWAQIKNSSPSLPYMTAVVLGSIAAICLILFLSFSAARSYLYRRVHSPPAALACEGVRLSATMDTARASSLETENVSLL", "length": 740 }, "evidence": [ { "id": "A0AAA9TCM6", "url": "https://omabrowser.org/oma/group/A0AAA9TCM6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9Q3H4-1", "protein_name": "Sushi domain containing 1", "gene_name": "Susd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRGPRGTRRSPGCGLQRLLRLVLLLSLARGVSGEPGTEDVDVCATCHEHATCQQKEGKRICICNYGFWGNGRTRCVDKDECQFGATVICGNHTSCHNTPGGFYCICHEGYRATNNNETFIPNDGTFCADIDECEDSGLCRHGGRCVNTPGSFACYCMEGYVAKNGPEPFHPRTDATSCTEIDCGIPPEVPEGYVVGSYSSTLGGQAHYSCKEGFLSVSGDRISRCTALGVWEPPKLHCQEISCGSPPEIQNAILVGNHSSRQGSVAHYDCQEGFESPGGKITSVCTEKGAWSEITYACTEIMIEIHDVLVFNDTCVRWQISPERVNARIVYLIRVERQQPDAAESVYEETVNVTTDSRTPEVCLHLQQGTNYTISISAAPPRRSVPAILGFQTPEDDLLEDDGLFNISVFNETCLTLSRHSRQVGSEQMYQVEVLGQRWYLESSYHAALFNFTTRDRAPEVCLDLYPATDYTINITLLRPTEPRSAQITITTSVTAKQTIANISVYNDTCLRWSSLKTADVLEMYLFHIWGQRWYQKAFVQEMVFNTTSSSQDPEICLDLHQGTSYNVSLQALSSALPVVIYLTTQITEPPLPEVDFFTVRGRPLPRFTLRKVKEINGPISSYQVLVLPLSLQSTFSCDSEGMTSFFGNTSPADGYVAAEILASDVPDDTLEISIGDRLYYGEYYNAPLKTGNEYCILLRITSEWNKVRRYSCAVWAEVKDSSLTAQQMVGVGLGSVAFVTILAFFSFSAV", "length": 752 }, "evidence": [ { "id": "A0AAA9TCM6", "url": "https://omabrowser.org/oma/group/A0AAA9TCM6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1SNB0-1", "protein_name": "Sushi domain containing 1", "gene_name": "SUSD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARGPRGAGFPPGRLLSLLLLLLLLCLARGAPRTPGADDSDVCASCHKHATCEQREGKKMCICKYGFVGNGRTHCIDKNECQFGATVVCGNHTSCHNTLGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSGLCRHGGRCVNTHGSFECYCMDGHLPKSGPEPFHPTRDATLCTEIDCGTPPEVPDGHIIGNYTSRFGSQVRYACKEGFFSDPEDTVSSCTASGTWESPKLNCQEINCGRPPEVPHAVLVGNHSSSLGGVAHYVCQEGFESSGGKITSVCTGKGTWRASAFTCTEIIIEINDLAVFNNTCVRWQRNPRRINSELVYEIHIKGQRLDPMESVHEETVNLTTNSRTPEVCLDLHQGTNYTVSISTTPPRRSVPAVIAFQTAEDDLLEDDGIFNISMFNEACLKLHRHSRKVGSEQVYQFKVLGQRQYLNNFYHSTSFNFTTRERAAVLCLDLYPATDYTVNVTLLGSPERHSVQITTTTAPAVKQTISNISVFNETCLRWRSMKTADIEEMYLFRIRGQRWYQKAFAQEVIFNITASSQTPETCLDLSPGTNYSISIQALSSELPVVISLTTRITEPPLPEIDFVTVHGGPLPRLRLRKAEEINGPISSYQVLVLPLALQSTFVCDSEEAPSFFSNASDAKGYVTAELLAKDIPNDAMEISIGDRLYYGKYYNAPLKKGNDYCIILRITSELNKVRRSSCAVWAQVKDSSLTLQQVVGVGLGSMAAVIVLAFLSFSAV", "length": 751 }, "evidence": [ { "id": "A0AAA9TCM6", "url": "https://omabrowser.org/oma/group/A0AAA9TCM6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6UWL2-1", "protein_name": "Sushi domain-containing protein 1", "gene_name": "SUSD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRGPWDAGPSRRLLPLLLLLGLARGAAGAPGPDGLDVCATCHEHATCQQREGKKICICNYGFVGNGRTQCVDKNECQFGATLVCGNHTSCHNTPGGFYCICLEGYRATNNNKTFIPNDGTFCTDIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRNGPEPFHPTTDATSCTEIDCGTPPEVPDGYIIGNYTSSLGSQVRYACREGFFSVPEDTVSSCTGLGTWESPKLHCQEINCGNPPEMRHAILVGNHSSRLGGVARYVCQEGFESPGGKITSVCTEKGTWRESTLTCTEILTKINDVSLFNDTCVRWQINSRRINPKISYVISIKGQRLDPMESVREETVNLTTDSRTPEVCLALYPGTNYTVNISTAPPRRSMPAVIGFQTAEVDLLEDDGSFNISIFNETCLKLNRRSRKVGSEHMYQFTVLGQRWYLANFSHATSFNFTTREQVPVVCLDLYPTTDYTVNVTLLRSPKRHSVQITIATPPAVKQTISNISGFNETCLRWRSIKTADMEEMYLFHIWGQRWYQKEFAQEMTFNISSSSRDPEVCLDLRPGTNYNVSLRALSSELPVVISLTTQITEPPLPEVEFFTVHRGPLPRLRLRKAKEKNGPISSYQVLVLPLALQSTFSCDSEGASSFFSNASDADGYVAAELLAKDVPDDAMEIPIGDRLYYGEYYNAPLKRGSDYCIILRITSEWNKVRRHSCAVWAQVKDSSLMLLQMAGVGLGSLAVVIILTFLSFSAV", "length": 747 }, "evidence": [ { "id": "A0AAA9TCM6", "url": "https://omabrowser.org/oma/group/A0AAA9TCM6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 77, "end_pos": 116, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TCM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM6" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 181, "end_pos": 240, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 197, "end_pos": 199 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 474, "end_pos": 476 }, { "start_pos": 502, "end_pos": 504 }, { "start_pos": 507, "end_pos": 509 }, { "start_pos": 546, "end_pos": 548 }, { "start_pos": 565, "end_pos": 567 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9E7-1", "uniprot_ac": "A0AAA9T9E7", "uniprot_id": "A0AAA9T9E7_BOVIN", "mass": { "chemical_mass": 71012.0, "monoisotopic_mass": 71012.0 }, "refseq": { "ac": "NP_001276748", "name": "basic helix-loop-helix ARNT-like protein 2", "summary": "This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. [provided by RefSeq, Feb 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276748" }, "gene_names": [ { "name": "ARNTL2", "type": "recommended", "evidence": [ { "id": "A0AAA9T9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ] }, { "name": "ARNTL2", "type": "synonym", "evidence": [ { "id": "NP_001276748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276748" } ] } ], "protein_names": [ { "name": "Aryl hydrocarbon receptor nuclear translocator like 2", "type": "synonym", "evidence": [ { "id": "A0AAA9T9E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7/entry#names_and_taxonomy" } ] }, { "name": "basic helix-loop-helix ARNT-like protein 2", "type": "synonym", "evidence": [ { "id": "NP_001276748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276748" } ] } ], "function": [ { "annotation": "This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. [provided by RefSeq, Feb 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001276748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276748" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARNTL2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7", "locus": { "chromosome": "5", "start_pos": 82468954, "end_pos": 82557896, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011804", "url": "https://www.ensembl.org/id/ENSBTAG00000011804" } ] } } ], "crossref": [ { "id": "A0AAA9T9E7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9E7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535794", "url": "https://www.ncbi.nlm.nih.gov/gene/535794", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535794", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535794", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23042", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23042", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14598", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001276748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276748", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9E7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEAEAAARGKVLMEGNQCIASVVSSHLSPWTKPIDTGSFSPHVTELPRKRRRSDSDPSQSGIMKEKVMEKLSQNPFTCLLSTRVEMSAFSCSRMEDGEQQVKIKSFREAHSQTEKRRRDKMNNLIGKLSTMIPQCSPMARKLDKLTVLRLAVQHLRSLKGMTSCYPGNNYRPSFIHDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSRILNYDQASLIGQSLFDFLHPKDVSKVKEQLSSSDISPREKLIDAKAALQVHSNFHTSKSHVYSGSRRSFFCRIKSCKISVKEEHEYLPNSKKKDHRKFCTVHCTGYLRSWPPNIAGMEEERDNKKDRSNFTCLVAVGRLQPHIVPQNSGEIKVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNLTDKHKAVLQSKEKIFTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTVVLGHSDAGETSLLPCSSQSSEGSSRQSFISVPGTSTEILLGAGSIGTDVASELLDLQRLQSSSSLDSNPTDLLKDTHTLNCRNMSDKELITLSPSEIGEREATKQNQSATAPLSHEPLLGEGVQLDLEALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIHWTL", "length": 635, "header": "tr|A0AAA9T9E7-1|A0AAA9T9E7_BOVIN Isoform 1 of Aryl hydrocarbon receptor nuclear translocator like 2 OS=Bos taurus OX=9913 GN=ARNTL2 PE=4 SV=1 CANONICAL=A0AAA9T9E7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7/entry#A0AAA9S6Z8-1", "sequence": { "sequence": "MRYCSLCLTGKVLMEGNQCIASVVSSHLSPWTKPIDTGSFSPHVTELPRKRRRSDSDPSQEAHSQTEKRRRDKMNNLIGKLSTMIPQCSPMARKLDKLTVLRLAVQHLRSLKGMTSCYPGNNYRPSFIHDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSRILNYDQASLIGQSLFDFLHPKDVSKVKEQLSSSDISPREKLIDAKAALQVHSNFHTSKSHVYSGSRRSFFCRIKSCKISVKEEHEYLPNSKKKDHRKFCTVHCTGYLRSWPPNIAGMEEERDNKKDRSNFTCLVAVGRLQPHIVPQNSGEIKVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNLTDKHKLQSKEKIFTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTVVLGHSDAGETSLLPCSSQSSEGSSRQSFISVPGTSTEILLGAGSIGTDVASELLDLQRLQSSSSLDSNPTDLLKDTHTLNCRNMSDKELITLSPSEIGEREATKQNQSATAPLSHEPLLGEGVQLDLEALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIHWTL", "length": 584, "header": "tr|A0AAA9S6Z8-1|A0AAA9T9E7_BOVIN Computationally mapped isoform of Aryl hydrocarbon receptor nuclear translocator like 2 OS=Bos taurus OX=9913 GN=ARNTL2 PE=4 SV=2 CANONICAL=A0AAA9T9E7-1" }, "locus": { "chromosome": "5", "start_pos": 82533886, "end_pos": 82469961, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126467.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126467.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079075.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079075.2" } ] } }, { "isoform_ac": "A0AAA9T9E7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7/entry#A0AAA9T9E7-1", "sequence": { "sequence": "MATEAEAAARGKVLMEGNQCIASVVSSHLSPWTKPIDTGSFSPHVTELPRKRRRSDSDPSQSGIMKEKVMEKLSQNPFTCLLSTRVEMSAFSCSRMEDGEQQVKIKSFREAHSQTEKRRRDKMNNLIGKLSTMIPQCSPMARKLDKLTVLRLAVQHLRSLKGMTSCYPGNNYRPSFIHDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSRILNYDQASLIGQSLFDFLHPKDVSKVKEQLSSSDISPREKLIDAKAALQVHSNFHTSKSHVYSGSRRSFFCRIKSCKISVKEEHEYLPNSKKKDHRKFCTVHCTGYLRSWPPNIAGMEEERDNKKDRSNFTCLVAVGRLQPHIVPQNSGEIKVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHSNLTDKHKAVLQSKEKIFTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTVVLGHSDAGETSLLPCSSQSSEGSSRQSFISVPGTSTEILLGAGSIGTDVASELLDLQRLQSSSSLDSNPTDLLKDTHTLNCRNMSDKELITLSPSEIGEREATKQNQSATAPLSHEPLLGEGVQLDLEALCDNDDTAMAAFMNYLEAEGGLGDPGDFSDIHWTL", "length": 635, "header": "tr|A0AAA9T9E7-1|A0AAA9T9E7_BOVIN Isoform 1 of Aryl hydrocarbon receptor nuclear translocator like 2 OS=Bos taurus OX=9913 GN=ARNTL2 PE=4 SV=1 CANONICAL=A0AAA9T9E7-1" }, "locus": { "chromosome": "5", "start_pos": 82557770, "end_pos": 82469961, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118136.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118136.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093479.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535794", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535794", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "circadian regulation of gene expression", "id": "GO:0032922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" }, { "name": "positive regulation of circadian rhythm", "id": "GO:0042753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042753", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9E7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9E7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 342, "end_pos": 344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 554, "end_pos": 556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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"enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 342, "end_pos": 344 }, { "start_pos": 415, "end_pos": 417 }, { "start_pos": 554, "end_pos": 556 }, { "start_pos": 577, "end_pos": 579 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TBA7-1", "uniprot_ac": "A0AAA9TBA7", "uniprot_id": "A0AAA9TBA7_BOVIN", "mass": { "chemical_mass": 41378.0, "monoisotopic_mass": 41378.0 }, "refseq": {}, "gene_names": [ { "name": "LETMD1", "type": "recommended", "evidence": [ { "id": "A0AAA9TBA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ] } ], "protein_names": [ { "name": "LETM1 domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TBA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LETMD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7", "locus": { "chromosome": "5", "start_pos": 28686002, "end_pos": 28695610, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010924", "url": "https://www.ensembl.org/id/ENSBTAG00000010924" } ] } } ], "crossref": [ { "id": "A0AAA9TBA7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TBA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR033122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14009", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14009:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14009:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07766", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07766", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQJ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALSRVCWARAALWGSAVPPGLYVVRRLQFVRSGLTWGAPRSSKLHLSPKADVKSLISYVVTKTKVINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADGKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRRDVTKCLFLGILSIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQIDFLDIYHALRKQSHPEILCYLEKVVPLISDAGLQWHMTELCTKMQRGTHPAVHDILALRECFANHPLGMDQLRALQMKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKENQTSFGFTLKILPVYSM", "length": 355, "header": "tr|A0AAA9TBA7-1|A0AAA9TBA7_BOVIN Isoform 1 of LETM1 domain containing 1 OS=Bos taurus OX=9913 GN=LETMD1 PE=4 SV=1 CANONICAL=A0AAA9TBA7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA05-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7/entry#A0AAA9SA05-1", "sequence": { "sequence": "MSSQERRMRCRRNATSSKLHLSPKADVKSLISYVVTKTKVINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADGKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRRDVTKCLFLGILSIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQIDFLDIYHALRKQSHPEILCYLEKVVPLISDAGLQWHMTELCTKMQRGTHPAVHDILALRECFANHPLGMDQLRALQMKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKETELSLLLHNVVLLSINYVGSRR", "length": 334, "header": "tr|A0AAA9SA05-1|A0AAA9TBA7_BOVIN Computationally mapped isoform of LETM1 domain containing 1 OS=Bos taurus OX=9913 GN=LETMD1 PE=4 SV=1 CANONICAL=A0AAA9TBA7-1" }, "locus": { "chromosome": "5", "start_pos": 28695411, "end_pos": 28688589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114898.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114898.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080256.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080256.1" } ] } }, { "isoform_ac": "A0AAA9TBA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7/entry#A0AAA9TBA7-1", "sequence": { "sequence": "MALSRVCWARAALWGSAVPPGLYVVRRLQFVRSGLTWGAPRSSKLHLSPKADVKSLISYVVTKTKVINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADGKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRRDVTKCLFLGILSIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQIDFLDIYHALRKQSHPEILCYLEKVVPLISDAGLQWHMTELCTKMQRGTHPAVHDILALRECFANHPLGMDQLRALQMKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKENQTSFGFTLKILPVYSM", "length": 355, "header": "tr|A0AAA9TBA7-1|A0AAA9TBA7_BOVIN Isoform 1 of LETM1 domain containing 1 OS=Bos taurus OX=9913 GN=LETMD1 PE=4 SV=1 CANONICAL=A0AAA9TBA7-1" }, "locus": { "chromosome": "5", "start_pos": 28695308, "end_pos": 28687006, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118123.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118123.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095264.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095264.1" } ] } }, { "isoform_ac": "A0AAA9TQJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7/entry#A0AAA9TQJ8-1", "sequence": { "sequence": "MALSRVCWARAALWGSAVPPGLYVVRRLQFVRSGLTWGAPRSSKLHLSPKADVKSLISYVVTKTKVINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADGKKARRIKTNMWKHNIKFHQLPYREMEHLRQKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKETELSLLLHNVVLLSINYVGSRR", "length": 236, "header": "tr|A0AAA9TQJ8-1|A0AAA9TQJ8_BOVIN Computationally mapped isoform of LETM1 domain containing 1 OS=Bos taurus OX=9913 GN=LETMD1 PE=4 SV=1 CANONICAL=A0AAA9TBA7-1" }, "locus": { "chromosome": "5", "start_pos": 28695308, "end_pos": 28688589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092360.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092360.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098693.1" } ] } }, { "isoform_ac": "A0AAA9TTJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7/entry#A0AAA9TTJ3-1", "sequence": { "sequence": "MALSRVCWARAALWGSAVPPGLYVVRRLQFVRSGLTWGAPRYLFPRQLLIRHFWTPKQQIDFLDIYHALRKQSHPEILCYLEKVVPLISDAGLQWHMTELCTKMQRGTHPAVHDILALRECFANHPLGMDQLRALQMKALCRAMLLTPYLPSVLLRHRLKTHTTVIHQLDKALAKLGVGQLTAQEVKSACYLRGLNSTHIAEERCRTWLGEWLQISCSLKETELSLLLHNVVLLSINYVGSRR", "length": 243, "header": "tr|A0AAA9TTJ3-1|A0AAA9TTJ3_BOVIN Computationally mapped isoform of LETM1 domain containing 1 OS=Bos taurus OX=9913 GN=LETMD1 PE=4 SV=1 CANONICAL=A0AAA9TBA7-1" }, "locus": { "chromosome": "5", "start_pos": 28695308, "end_pos": 28688589, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131139.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131139.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101948.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" }, { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" }, { "name": "regulation of phagocytosis", "id": "GO:0050764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050764", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA7" }, { "id": "PS51758", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51758" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Letm1 RBD", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 355, "start_aa": "Leu", "end_aa": "Met", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 313, "end_pos": 315 }, { "start_pos": 339, "end_pos": 341 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TD12-1", "uniprot_ac": "A0AAA9TD12", "uniprot_id": "A0AAA9TD12_BOVIN", "mass": { "chemical_mass": 69482.0, "monoisotopic_mass": 69482.0 }, "refseq": {}, "gene_names": [ { "name": "AVL9", "type": "recommended", "evidence": [ { "id": "A0AAA9TD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" } ] } ], "protein_names": [ { "name": "AVL9 cell migration associated", "type": "synonym", "evidence": [ { "id": "A0AAA9TD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AVL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12", "locus": { "chromosome": "4", "start_pos": 63946650, "end_pos": 64010264, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003114", "url": "https://www.ensembl.org/id/ENSBTAG00000003114" } ] } } ], "crossref": [ { "id": "A0AAA9TD12", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TD12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003114", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003114", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534141", "url": "https://www.ncbi.nlm.nih.gov/gene/534141", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534141", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534141", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IRTQFRV", "url": "https://omabrowser.org/oma/group/IRTQFRV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N025", "url": "https://www.orthodb.org/?gene=F1N025", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31017", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31017", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31017:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31017:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SA63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBY8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N025", "url": "https://www.uniprot.org/uniprotkb/F1N025", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N025-1", "url": "https://www.uniprot.org/uniprotkb/F1N025-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNSVQNSERGKKLGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTSSTPQSLTELPDGKP", "length": 628, "header": "tr|A0AAA9TD12-1|A0AAA9TD12_BOVIN Isoform 1 of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=1 CANONICAL=A0AAA9TD12-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SA63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#A0AAA9SA63-1", "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKLGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTSSTPQSLTELPDGKP", "length": 633, "header": "tr|A0AAA9SA63-1|A0AAA9TD12_BOVIN Computationally mapped isoform of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=1 CANONICAL=A0AAA9TD12-1" }, "locus": { "chromosome": "4", "start_pos": 64010001, "end_pos": 63956369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095159.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095159.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080807.1" } ] } }, { "isoform_ac": "A0AAA9SBY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#A0AAA9SBY8-1", "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKLGNVMVTTSRNVVQTGKAVGPLQNFA", "length": 615, "header": "tr|A0AAA9SBY8-1|A0AAA9TD12_BOVIN Computationally mapped isoform of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=1 CANONICAL=A0AAA9TD12-1" }, "locus": { "chromosome": "4", "start_pos": 64010001, "end_pos": 63947654, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107490.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107490.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082899.1" } ] } }, { "isoform_ac": "A0AAA9T1V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#A0AAA9T1V8-1", "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKLGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTSSTPQSLTELPDGKP", "length": 646, "header": "tr|A0AAA9T1V8-1|A0AAA9TD12_BOVIN Computationally mapped isoform of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=1 CANONICAL=A0AAA9TD12-1" }, "locus": { "chromosome": "4", "start_pos": 64010001, "end_pos": 63956369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105642.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105642.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091728.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091728.1" } ] } }, { "isoform_ac": "A0AAA9TD12-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#A0AAA9TD12-1", "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNSVQNSERGKKLGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTSSTPQSLTELPDGKP", "length": 628, "header": "tr|A0AAA9TD12-1|A0AAA9TD12_BOVIN Isoform 1 of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=1 CANONICAL=A0AAA9TD12-1" }, "locus": { "chromosome": "4", "start_pos": 64010001, "end_pos": 63956369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108591.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108591.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094736.1" } ] } }, { "isoform_ac": "F1N025-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12/entry#F1N025-1", "sequence": { "sequence": "MEIRRGGDGPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATIYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGTSLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDSSQYRPRKSMSEDAGLQESNPPADEFVSVPASDISNTNLGTVKKILGNHGGDAAIKTEEPLFQVEDDSSEQEASDSNQYLKPPSRPSPESSESDWETLDPTVLEDSSLKEREQVGSEQTNSFPKDSLPSDSPPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTIRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPKTCLPRDLHFRLCHGERMVPLRLLDQRCLAFILIGWEI", "length": 598, "header": "tr|F1N025-1|A0AAA9TD12_BOVIN Computationally mapped isoform of AVL9 cell migration associated OS=Bos taurus OX=9913 GN=AVL9 PE=3 SV=3 CANONICAL=A0AAA9TD12-1" }, "locus": { "chromosome": "4", "start_pos": 64010001, "end_pos": 63951198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004049.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004049.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004049.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004049.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534141", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534141", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IRC7-1", "protein_name": "Late secretory pathway protein AVL9 homolog isoform 2", "gene_name": "avl9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MECQSKEEPVLHIVVVGFHHKKGCQVEFSYPPIIPSAGHDSSTLPEEWKYLPFLALPDGAHNHQEDTVYFHLPPLDGQLKCVYGVSCYRQMEAKALKKREADVTRETVQKSVCVLSRLPLFGLIQAKLQLITHAYFEEKDFSQISILKELYDHMNRSLNCTSLEGSQIYLSLSARDLILHFKHKVLVLFKLILLEKKILFYVTPVKRLVETLMTILSLFPGMIEYGLADSSHYQTRRSISEDFSSPEIISADEESLSLFSTDITRTPKENEHRYDVNDPPDQSKPCNSTLDTHYIDARAEQQNLLDSSESEWETLEPHVMDEKESKMDIGHLEMFDADSGLPITVQPQSATGHGTLSTGLVSGLQEDQYGQPLAIFTKGYLCMPYMALQQHHLLSDINVRGFVSGATNVLFRQQRHLSDAVVDVDEAQILIHDPELRKMLNLSTADLRFADYLVKHVTENKEDVFLDGTGWEGGDEWIRAQFGLYMHSLLSSALQQDHERLLADYGVLFTSAWKMTHNYKMWISNKHPAMAEITPGHPFQGQYSVADVKIRLSHSMQNSERGKKIGNAVMSTSRSVVQTGKAVGQSVGGALTVAKSAMSSWFSMLAQPTAAVTSSQQSSD", "length": 620 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8I5ZNY0-1", "protein_name": "AVL9 cell migration associated", "gene_name": "Avl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKAGRESDGAPCGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHAVPEEWKYLPSLALPDGAHNYQEDTVFFHLPPRNGNGATVYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDAGLQEGNPSADDFISESTSDNLNTSLGIVTRIVAVNHGEDAVPPTEKPYFQVEGNNNKGQEHSDTGRYLELPPRPSPESSESDWETLDPSVLEDASLKEREQMGSDQTHLFQKDSVPSDSPPITVQPQANTRQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKMLSDYGTTFVAAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKIGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTPQSLPEPPNGKP", "length": 649 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZAB7-1", "protein_name": "AVL9 cell migration associated", "gene_name": "AVL9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEKRGAPPAAPPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGEGHDSHNLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRCGDRTTVYGVSCYRQIEAKALKVRQADITRETVQKSVCVLSQLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYDHMNSSLGGTLLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLTDSSHYRPRKSVSEDAGLQETTPWLDNSTSVSAGGISNTNLGTGKGGKKMAGNHSVEGQKANIPFCQSEKTYNGAQSSNGTVQHLEVPSRTSPESSESDWETLDPSILEESSMKGECEKAALEQVENRPSECPSSESLPITVQPQANTGHMVLVPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEIEDAHVQIHDPELRKILNPTTADLRFADYLVKHVTENRDDVFLDGTGWEGGDEWIRAQFSAYLHALLASVLQPDNEKTLSDFGTAFVAAWKNTHNYRVWNSNKHPALAEVHSSHPFQGQYSVSDVKLRLSHSVQNSERGKKIGNVMVSTSRNVVQTGKAVGQSVGGAFTSAKSAMSSWFSTFTQSSQSLGD", "length": 644 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HMP7-1", "protein_name": "Late secretory pathway protein AVL9 homolog isoform X1", "gene_name": "Avl9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKAGREGDGAPCGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHALPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDIGLQQSNPPADDFISESTSDISNTNLGTVTKIISGNHGGDTVLQLEKPCFQVEDNNNKEQEPSDTGRYLKLPPRPSPESSESDWETLDPSVLEDSSLKEREQMESDQTNIFQKDSVPSDSPPITVQPQANTRQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKMLSDYGTTFVAAWKNTHNYRVWNSNKHPALSEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKIGNVMVSTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTPQSLPEPPNGKP", "length": 649 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q12500-1", "protein_name": "Late secretory pathway protein AVL9", "gene_name": "AVL9", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDEHEEAVIFGICLVDFHHKRGPEIEYWYGLPEGTQSAELWPNLPFQALPDGSHSFEETFTYFTLLYDERRQRSPPNGATDLSDDSINDNTTLFAISCSRQIKSDELVTKDKDVTRSTVQKAIVVISRQPIFGQIKDKLSIVTNAFFLQHDFGDRKIIQSLYENLKSIYTPASLVRNAENRLYIGLCLRKILHDFKRNALVLLKAIMLEKKIIVYGNDVEALCNLQFGLISLIPDLMSNLQDSGSPQLFQDISKLNVVDSFKSSNRESVLRFLGFPLPIFEKGGLFSPYTPLQQMNDIRSERTLFFMIGSSNTLLAEQKEELCHIFVNTDNSTVDILDKTLNPVLQLSSHDKKWIESISGIVSDTWNENDDETPKNSQFEGSEDFIRWQFEDYLTGLLSSVKLSDYLDLHKENDQALKTIPEDMLNSNPVHLFNLNWVQSWKETQNFLIFNSRTDDRLFDLFPPKHIYNGADTLSLLQQRFLATFHNLKRSSSNSSSNKNGHQSEEDIKDQESIESKKSVSQISVNPGKNTDKPAANLWNSWKEYFNKPKNTANEDVTESTEDLKNRSKTSNAIQKAMMGLGLHYKPDAETDQQSEEVGNSEDNEDDDTDEDSEDDDDDGGDDDDSEDDDDDDDGEGDENGDDGEGDENGDDGEGDENGDKEDSQDFSNGFTDVTNINTDHDKENEQNFEGNAENFNEDETVADKDIEGGPESNKNSDSKTDIYENDRNVEDSSKTRNTVKKSNEEGGANDAAIGNCVQDEEKL", "length": 764 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54NJ9-1", "protein_name": "UDENN domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSINLIEYIGVIGFHHSLGHRIEFLYPDLDEESKKQYNWNLLPFYGIADGVHNSFEDYTFFIMEEINPTTSPSKKLYGLSYFKQKNKRDLPKQAITPEDTRSSIQKSVVILSKFPIFNSFKTQLSSATICYFNQGDFQNTDLLVTWFHAQNNEFKERNNEKLVINNSFGYQMNQVLENNNNNNKKLIPINSDFLFGSMSLKKLIMHFGRNSLVFFKLIMLERGVVVFCPQPVSPVSEAIMSVLSLHSKSYDLLFSTNQSISNDFQIDWTTSTSEEMVLNQLGLPIPLFNDGKDNNTTNSDGEKVYGSGGMILQPYLPLQQISLLLPPQQGSGKTFNGFLVGTSNSLFLKNPPSTVHAIVDIQNGEIQFKDESLNRIMELTSSDRRFIDNIYDKVELYNRNNSNNNNNNNNNNNNNNNNGNNSDNDNAVYKEGCDKWIRDQFENYIVCLLSSICRFIKIEDGKNVLTNMDQLAQYNDSWIRRWTTTKNFYLWKKQMFQNLPLPQLNYPVHPSGPPSDMLDRFQDKLTTSIKDLQPLTNQFSQLFSFTSTFLRNQINNNNNNSSNNNNNNFDNIDDNGEQQKQQIYNTHILKSSYSQEFYSSGDDINSTNTTWSKVQENGIIAATKAVSAVKPLVSSSKTMARQFSNQLMNYIAPHPSLDIPQLNQNDQDNSIFESQANEYDFIGNYYSNNNNNNHNNNNNNSNNNNDDDNYNNNNNNNNNTNSNNNNNNSNDNNGTYTIAPITTTSTTTKSSSTKIVGIISTSNDDNNDESINGISNEKKSYQLPSDTRDDAYEL", "length": 794 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q80U56-1", "protein_name": "Late secretory pathway protein AVL9 homolog", "gene_name": "Avl9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKSGRESDGAPCGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVYGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNRLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDAGPQESNPSADDFTSESTSDVLNTSLETVTRVMAVNHGEDAVPKTEKPYFQVEGNNNKGQEPSDSGRYLELPPRPSPESSESDWETLDPSVLEDASLKEREQMGSDQTHLFQKDSLPSDSPPITVQPQANNRQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKMLSDYGTTFVAAWKNTHNYRVWNSNKHPALSEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKIGSVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTPQSLPEPPNGKP", "length": 649 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NBF6-1", "protein_name": "Late secretory pathway protein AVL9 homolog", "gene_name": "AVL9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKARRGGDGVPRGPVLHIVVVGFHHKKGCQVEFSYPPLIPGDGHDSHTLPEEWKYLPFLALPDGAHNYQEDTVFFHLPPRNGNGATVFGISCYRQIEAKALKVRQADITRETVQKSVCVLSKLPLYGLLQAKLQLITHAYFEEKDFSQISILKELYEHMNSSLGGASLEGSQVYLGLSPRDLVLHFRHKVLILFKLILLEKKVLFYISPVNKLVGALMTVLSLFPGMIEHGLSDCSQYRPRKSMSEDGGLQESNPCADDFVSASTADVSHTNLGTIRKVMAGNHGEDAAMKTEEPLFQVEDSSKGQEPNDTNQYLKPPSRPSPDSSESDWETLDPSVLEDPNLKEREQLGSDQTNLFPKDSVPSESLPITVQPQANTGQVVLIPGLISGLEEDQYGMPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQKHLSDAIVEVEEALIQIHDPELRKLLNPTTADLRFADYLVRHVTENRDDVFLDGTGWEGGDEWIRAQFAVYIHALLAATLQLDNEKILSDYGTTFVTAWKNTHNYRVWNSNKHPALAEINPNHPFQGQYSVSDMKLRFSHSVQNSERGKKIGNVMVTTSRNVVQTGKAVGQSVGGAFSSAKTAMSSWLSTFTTSTSQSLTEPPDEKP", "length": 648 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VYB2-1", "protein_name": "UDENN domain-containing protein", "gene_name": "Dmel\\CG11178", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASEPENKPPILHILVVGFHHKLGCQVEFSHPPLISGSTGRNECPSGWKYLPTLALPDGSHNFAEDTVFFNLPSLYEPAESIYGVSCYRQIRVEKLKIRTADLTRSTVQKSVCILARLPIYGYIEVKLALIADAFFDQGDFSGTELLAKAYQQLNACLQDDESRRPLRHFHVGLSLREIVLHWRHKTLMLFKLMLLQRRVVCFGSPVRQMCVLILGMASLVPRLLEKGFQEVACVRTSRPLSPMPDFTDSLQREAQAEAEAELEAVASVAAATDEQKLTPESATAVEGEAEELALVSSAASAGEEQVSGDDTSTRSTPNSQSQDSSNGRNSSLTREASVDTLASNLAALCAVNPDEYRAPVSIFASGNLCLPYLSLPYMDLLSDPMVLSYVIGTSNVLFQQKRQLADVLVDIEAANLDAHDPELRRQLVLSTEDLRYMDYIMKHVQSPKEDAEGSEYWIREQFQGYILALLRTAVAPDATPKDNDHFNAHFMGAFKRTQCFQEWYDVRPEPEFFEALPAGHPFAGTLSVADMKLKLAQTMQNSESGRKINQAVNTTSRAVGGAISQAKGAFSSWWSSITTAPPNATNAGPATSSSNGQEGDVSEGAAAQEISVTFQNHKDVEDLDVAGVSIHLAGQEEAHESHESQSVSCDKPQGIVEIGREAELLDKTAQSEEPKIAAASQAGRPGCGGDVATSAVERSSGDVFIV", "length": 707 }, "evidence": [ { "id": "A0AAA9TD12", "url": "https://omabrowser.org/oma/group/A0AAA9TD12/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TD12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD12" }, { "id": "PS50211", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50211" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UDENN", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 573, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 160, "end_pos": 162 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9F6-1", "uniprot_ac": "A0AAA9T9F6", "uniprot_id": "A0AAA9T9F6_BOVIN", "mass": { "chemical_mass": 106247.0, "monoisotopic_mass": 106247.0 }, "refseq": {}, "gene_names": [ { "name": "CUL4B", "type": "recommended", "evidence": [ { "id": "A0AAA9T9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6" } ] } ], "protein_names": [ { "name": "Cullin-4B", "type": "recommended", "evidence": [ { "id": "A0AAA9T9F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CUL4B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6", "locus": { "chromosome": "X", "start_pos": 5086075, "end_pos": 5135456, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018569", "url": "https://www.ensembl.org/id/ENSBTAG00000018569" } ] } } ], "crossref": [ { "id": "A0AAA9T9F6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9F6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018569", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018569", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539668", "url": "https://www.ncbi.nlm.nih.gov/gene/539668", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKZ4", "url": "https://www.orthodb.org/?gene=A0A3Q1LKZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BFD5", "url": "https://www.orthodb.org/?gene=E1BFD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11932", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11932", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00888", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00888", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110314", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110314", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696395", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696395", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696400", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696400", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6781823", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6782135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6782210", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782210", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKZ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAN6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFD5", "url": "https://www.uniprot.org/uniprotkb/E1BFD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFD5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSVCPVTSGFSSPNPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSGSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFSCLGVPVTAPSHVPIQKKLRFEENLEFVGFDAKMAEESSSSSSSSPTAATSQQQQLKNKSILISTVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQERPQEMMFLWIVLIILRCSSSKKRIKKAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA", "length": 928, "header": "tr|A0AAA9T9F6-1|A0AAA9T9F6_BOVIN Isoform 1 of Cullin-4B OS=Bos taurus OX=9913 GN=CUL4B PE=3 SV=1 CANONICAL=A0AAA9T9F6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6/entry#A0A3Q1LKZ4-1", "sequence": { "sequence": "TMSQSPGSLDGSDDEAVPEGSKGEAFSGFSSPNPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSGSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFSCLGVPVTAPSHVPIQKKLRFEENLEFVGFDAKMAEESSSSSSSSPTAATSQQQQLKNKSILISTVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA", "length": 919, "header": "tr|A0A3Q1LKZ4-1|A0A3Q1LKZ4_BOVIN Computationally mapped isoform of Cullin-4B OS=Bos taurus OX=9913 GN=CUL4B PE=3 SV=2 CANONICAL=A0AAA9T9F6-1" }, "locus": { "chromosome": "X", "start_pos": 5130130, "end_pos": 5087079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072958.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072958.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060403.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060403.2" } ] } }, { "isoform_ac": "A0AAA9SAN6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6/entry#A0AAA9SAN6-1", "sequence": { "sequence": "MIDPDFTDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA", "length": 717, "header": "tr|A0AAA9SAN6-1|A0AAA9T9F6_BOVIN Computationally mapped isoform of Cullin-4B OS=Bos taurus OX=9913 GN=CUL4B PE=3 SV=1 CANONICAL=A0AAA9T9F6-1" }, "locus": { "chromosome": "X", "start_pos": 5115800, "end_pos": 5087079, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132483.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132483.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080514.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080514.1" } ] } }, { "isoform_ac": "A0AAA9T9F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9F6/entry#A0AAA9T9F6-1", "sequence": { "sequence": "MKSVCPVTSGFSSPNPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLNSSSSSSGSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFSCLGVPVTAPSHVPIQKKLRFEENLEFVGFDAKMAEESSSSSSSSPTAATSQQQQLKNKSILISTVASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQERPQEMMFLWIVLIILRCSSSKKRIKKAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA", "length": 928, "header": "tr|A0AAA9T9F6-1|A0AAA9T9F6_BOVIN Isoform 1 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"https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#names_and_taxonomy" } ] }, { "name": "Polyamine oxidase", "type": "synonym", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#names_and_taxonomy" } ] }, { "name": "peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005225508", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225508" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAOX", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3", "locus": { "chromosome": "26", "start_pos": 25599864, "end_pos": 25629653, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018321", "url": "https://www.ensembl.org/id/ENSBTAG00000018321" } ] } } ], "crossref": [ { "id": "A0AAA9TBR3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TBR3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018321", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018321", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282639", "url": "https://www.ncbi.nlm.nih.gov/gene/282639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10742:SF405", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10742:SF405", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01593", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141334", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141334", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-351200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225508", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225508", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "25800", "url": "https://www.rhea-db.org/rhea/25800", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25812", "url": "https://www.rhea-db.org/rhea/25812", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "25868", "url": "https://www.rhea-db.org/rhea/25868", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLI5", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG47", "url": "https://www.uniprot.org/uniprotkb/F1MG47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG47-1", "url": "https://www.uniprot.org/uniprotkb/F1MG47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQP7", "url": "https://www.uniprot.org/uniprotkb/F1MQP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQP7-1", "url": "https://www.uniprot.org/uniprotkb/F1MQP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVGSCSSTGLELRRRRWQMPLFSRWQMLLGRRLSPSDLTPRHRGPRALEVKALARASEAEKRLLLRLLAPFPRLLRTRTRPEQASRPPALSLGGDGRLQRRHRWIIHRPLRAGPRTSERPSATFPRAAGDSPEPPGTTAMQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHSFGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQLQVLFAGEATHRTFYSTTHGALLSGWREADRLMTLWDPQAQWPEPRL", "length": 652, "header": "tr|A0AAA9TBR3-1|A0AAA9TBR3_BOVIN Isoform 1 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=1 CANONICAL=A0AAA9TBR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#A0AAA9SBP6-1", "sequence": { "sequence": "MPLFSRWQMLLGRRLSPSDLTPRHRGPRALEVKALARASEAEKRLLLRLLAPFPRLLRTRTRPEQASRPPALSLGGDGRLQRRHRWIIHRPLRAGPRTSERPSATFPRAAGDSPEPPGTTAMQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHSFGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQLQVLFAGEATHRTFYSTTHGALLSGWREADRLMTLWDPQAQWPEPRL", "length": 633, "header": "tr|A0AAA9SBP6-1|A0AAA9TBR3_BOVIN Computationally mapped isoform of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=1 CANONICAL=A0AAA9TBR3-1" }, "locus": { "chromosome": "26", "start_pos": 25628907, "end_pos": 25602253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088207.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088207.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079646.1" } ] } }, { "isoform_ac": "A0AAA9TBR3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#A0AAA9TBR3-1", "sequence": { "sequence": "MKVGSCSSTGLELRRRRWQMPLFSRWQMLLGRRLSPSDLTPRHRGPRALEVKALARASEAEKRLLLRLLAPFPRLLRTRTRPEQASRPPALSLGGDGRLQRRHRWIIHRPLRAGPRTSERPSATFPRAAGDSPEPPGTTAMQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHSFGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQLQVLFAGEATHRTFYSTTHGALLSGWREADRLMTLWDPQAQWPEPRL", "length": 652, "header": "tr|A0AAA9TBR3-1|A0AAA9TBR3_BOVIN Isoform 1 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=1 CANONICAL=A0AAA9TBR3-1" }, "locus": { "chromosome": "26", "start_pos": 25628964, "end_pos": 25602253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094122.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094122.1" } ] } }, { "isoform_ac": "A0AAF6DLI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#A0AAF6DLI5-1", "sequence": { "sequence": "MKVGSCSSTGLELRRRRWQMPLFSRWQMLLGRRLSPSDLTPRHRGPRALEVKALARASEAEKRLLLRLLAPFPRLLRTRTRPEQASRPPALSLGGDGRLQRRHRWIIHRPLRAGPRTSERPSATFPRGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQLQVLFAGEATHRTFYSTTHGALLSGWREADRLMTLWDPQAQWPEPRL", "length": 578, "header": "tr|A0AAF6DLI5-1|A0AAF6DLI5_BOVIN Computationally mapped isoform of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=1 CANONICAL=A0AAA9TBR3-1" }, "locus": { "chromosome": "26", "start_pos": 25628964, "end_pos": 25602253, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063985.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063985.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053903.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053903.3" } ] } }, { "isoform_ac": "F1MG47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#F1MG47-1", "sequence": { "sequence": "MQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHSFGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQNMVKEEPGFFNLMKTGPLRTPGTARVRPWLVALPEARPRDPARPPAASPAPSLVPSPVPTPGPRPSPSTGR", "length": 536, "header": "tr|F1MG47-1|A0AAA9TBR3_BOVIN Computationally mapped isoform of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=3 CANONICAL=A0AAA9TBR3-1" }, "locus": { "chromosome": "26", "start_pos": 25610397, "end_pos": 25600026, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024380.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024380.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024380.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024380.5" } ] } }, { "isoform_ac": "F1MQP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3/entry#F1MQP7-1", "sequence": { "sequence": "MQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHSFGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSGVSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKLKLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKDVMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDYFPAHHVVVTVPLGFFKKHLDTFFEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDTSPLEDTAPELQDAWFKKLIGFWVLPPFHRASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAPRSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQRGFPGGSVVENLPAMQETRAQSLGQEDPLEKEIATHSSILAWRIPWTEEPDGLQSVGSQRVRHD", "length": 530, "header": "tr|F1MQP7-1|A0AAA9TBR3_BOVIN Computationally mapped isoform of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus OX=9913 GN=PAOX PE=3 SV=3 CANONICAL=A0AAA9TBR3-1" }, "locus": { "chromosome": "26", "start_pos": 25610397, "end_pos": 25604051, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057083.3", "url": "https://www.ensembl.org/id/ENSBTAT00000057083.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048799.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048799.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-141334", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141334", "resource": "Reactome", "description": "PAOs oxidise polyamines to amines" }, { "id": "R-BTA-351200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-351200", "resource": "Reactome", "description": "Interconversion of polyamines" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity", "id": "GO:0052903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "polyamine oxidase activity", "id": "GO:0046592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046592", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "spermidine catabolic process", "id": "GO:0046203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "putrescine biosynthetic process", "id": "GO:0009446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009446", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "putrescine catabolic process", "id": "GO:0009447", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009447", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "spermine catabolic process", "id": "GO:0046208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046208", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" }, { "name": "positive regulation of spermidine biosynthetic process", "id": "GO:1901307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "25800", "name": "", "equation": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q865R1-1", "A0AAA9TBR3-1" ], "evidence": [ { "id": "25800", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25800" } ] }, { "id": "25812", "name": "", "equation": "N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q865R1-1", "A0AAA9TBR3-1" ], "evidence": [ { "id": "25812", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25812" } ] }, { "id": "25868", "name": "", "equation": "N(1),N(12)-diacetylspermine + O2 + H2O = 3-acetamidopropanal + N(1)-acetylspermidine + H2O2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q865R1-1", "A0AAA9TBR3-1" ], "evidence": [ { "id": "25868", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25868" } ] }, { "id": "R-BTA-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-113535", "R-ALL-141349", "R-ALL-141343" ], "output_participant_list": [ "R-ALL-141327", "R-ALL-141350" ], "enzyme_list": [ "A0AAA9TBR3-1" ], "evidence": [ { "id": "R-BTA-141348", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141348" } ] }, { "id": "R-BTA-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-141323" ], "output_participant_list": [ "R-ALL-141324" ], "enzyme_list": [ "A0AAA9TBR3-1" ], "evidence": [ { "id": "R-BTA-141351", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141351" } ] }, { "id": "R-BTA-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033235" } ] }, { "id": "R-BTA-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033236" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113535", "participant_name": "O2 [peroxisomal matrix]", "crossref": [ { "id": "15379", "database": "ChEBI", "url": "" }, { "id": "8145133", "database": "PubChem Substance", "url": "" }, { "id": "C00007", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001377", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-141323", "participant_name": "NASPN [peroxisomal matrix]", "crossref": [ { "id": "58101", "database": "ChEBI", "url": "" }, { "id": "ZINC000003870097", "database": "ZINC", "url": "" }, { "id": "HMDB0062644", "database": "HMDB Metabolite", "url": "" }, { "id": "C02567", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-141324", "participant_name": "SPM [peroxisomal matrix]", "crossref": [ { "id": "ZINC000001532612", "database": "ZINC", "url": "" }, { "id": "C00315", "database": "COMPOUND", "url": "" }, { "id": "57834", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-141327", "participant_name": "3AAPNAL [peroxisomal matrix]", "crossref": [ { "id": "ZINC000013542048", "database": "ZINC", "url": "" }, { "id": "30322", "database": "ChEBI", "url": "" }, { "id": "HMDB0012880", "database": "HMDB Metabolite", "url": "" }, { "id": "8146179", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-141343", "participant_name": "H2O [peroxisomal matrix]", "crossref": [ { "id": "15377", "database": "ChEBI", "url": "" }, { "id": "8145132", "database": "PubChem Substance", "url": "" }, { "id": "C00001", "database": "COMPOUND", "url": "" }, { "id": "HMDB0002111", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-141349", "participant_name": "NASPM [peroxisomal matrix]", "crossref": [ { "id": "58324", "database": "ChEBI", "url": "" }, { "id": "ZINC000001532698", "database": "ZINC", "url": "" }, { "id": "C00612", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-141350", "participant_name": "PTCN [peroxisomal matrix]", "crossref": [ { "id": "ZINC000005828633", "database": "ZINC", "url": "" }, { "id": "326268", "database": "ChEBI", "url": "" }, { "id": "C00134", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LQH8", "gene_name": "GNPAT", "activity": [ { "ec_number": "2.3.1.42", "activity": "dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LTU2", "gene_name": "PEX10", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LYY4", "gene_name": "CRAT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] } ] }, { "uniprot_ac": "A0AAA9SAI8", "gene_name": "TYSND1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "A0AAA9SAI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI8" } ] } ] }, { "uniprot_ac": "A0AAA9SC38", "gene_name": "HAO1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A0AAA9SXG3", "gene_name": "DAO", "activity": [ { "ec_number": "1.4.3.3", "activity": "D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+).", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] } ] }, { "uniprot_ac": "A0AAA9TBR3", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TYP4", "gene_name": "PECR", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] } ] }, { "uniprot_ac": "A0AAA9TZC7", "gene_name": "ECI2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "F1MV74", "gene_name": "SCP2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] } ] }, { "uniprot_ac": "F1MVP8", "gene_name": "HACL1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] } ] }, { "uniprot_ac": "F1MYR5", "gene_name": "NOS2", "activity": [ { "ec_number": "1.14.13.39", "activity": "2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O.", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "O19094", "gene_name": "CROT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q29448", "gene_name": "HMGCL", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] } ] }, { "uniprot_ac": "Q29RU9", "gene_name": "PIPOX", "activity": [ { "ec_number": "1.5.3.1", "activity": "sarcosine + O2 + H2O = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+).", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] } ] }, { "uniprot_ac": "Q3SX23", "gene_name": "LONP2", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "Q3SX23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX23" } ] } ] }, { "uniprot_ac": "Q3SZP5", "gene_name": "ACOX1", "activity": [ { "ec_number": "1.3.3.6", "activity": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] }, { "ec_number": "1.3.3.6", "activity": "", "evidence": [ { "id": "Q3SZP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZP5" } ] } ] }, { "uniprot_ac": "Q3ZBW2", "gene_name": "HAO2", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "Q3ZBW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBW2" } ] } ] }, { "uniprot_ac": "Q865R1", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "Q865R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865R1" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "Q865R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q865R1" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" }, { "id": "PF01593", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01593" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amine oxidase", "eco_id": "ECO_0000259", "start_pos": 164, "end_pos": 637, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.5.3.13", "ec_name": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "1.5.3.13", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13" }, { "id": "1.5.3.13", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.5.3.13" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 394, "end_pos": 396 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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}, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TC75-1", "uniprot_ac": "A0AAA9TC75", "uniprot_id": "A0AAA9TC75_BOVIN", "mass": { "chemical_mass": 21802.0, "monoisotopic_mass": 21802.0 }, "refseq": {}, "gene_names": [ { "name": 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"https://www.ebi.ac.uk/interpro/entry/IPR017288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052133", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052133", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12044", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12044", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12044:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12044:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08945", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08945", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SEN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKQPSDVSSECDREGGQLQPAERPPQLRPGAPTSLQTERQGNPEGEGDRCPQGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQSQAVPADTRPEIWIAQELRRIGDEFNAYYPRRLAASSFPNQELNPGSESADSTPLDLQRIPLLFFFK", "length": 199, "header": "tr|A0AAA9TC75-1|A0AAA9TC75_BOVIN Isoform 1 of BCL2 like 11 OS=Bos taurus OX=9913 GN=BCL2L11 PE=4 SV=1 CANONICAL=A0AAA9TC75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75/entry#A0AAA9SEN0-1", "sequence": { "sequence": "MAKQPSDVSSECDREGGQLQPAERPPQLRPGAPTSLQTERQGNPEGEGDRCPQGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQSQAVPADTRPEIWIAQELRRIGDEFNAYYPRRVFVRHQAVEGHPQMVLLRVLRYIVRLVWRMQ", "length": 195, "header": "tr|A0AAA9SEN0-1|A0AAA9TC75_BOVIN Computationally mapped isoform of BCL2 like 11 OS=Bos taurus OX=9913 GN=BCL2L11 PE=4 SV=2 CANONICAL=A0AAA9TC75-1" }, "locus": { "chromosome": "11", "start_pos": 1232043, "end_pos": 1189981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132164.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132164.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080860.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080860.2" } ] } }, { "isoform_ac": "A0AAA9TC75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75/entry#A0AAA9TC75-1", "sequence": { "sequence": "MAKQPSDVSSECDREGGQLQPAERPPQLRPGAPTSLQTERQGNPEGEGDRCPQGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQSQAVPADTRPEIWIAQELRRIGDEFNAYYPRRLAASSFPNQELNPGSESADSTPLDLQRIPLLFFFK", "length": 199, "header": "tr|A0AAA9TC75-1|A0AAA9TC75_BOVIN Isoform 1 of BCL2 like 11 OS=Bos taurus OX=9913 GN=BCL2L11 PE=4 SV=1 CANONICAL=A0AAA9TC75-1" }, "locus": { "chromosome": "11", "start_pos": 1232043, "end_pos": 1157313, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123753.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123753.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095659.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "Bcl-2 family protein complex", "id": "GO:0097136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex assembly", "id": "GO:0031334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031334", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "positive regulation of release of cytochrome c from mitochondria", "id": "GO:0090200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "response to endoplasmic reticulum stress", "id": "GO:0034976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "positive regulation of fibroblast apoptotic process", "id": "GO:2000271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000271", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TBM6-1", "uniprot_ac": "A0AAA9TBM6", "uniprot_id": "A0AAA9TBM6_BOVIN", "mass": { "chemical_mass": 74825.0, "monoisotopic_mass": 74825.0 }, "refseq": {}, "gene_names": [ { "name": "IGFALS", "type": "recommended", "evidence": [ { "id": "A0AAA9TBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6" } ] } ], "protein_names": [ { "name": "Insulin-like growth factor-binding protein complex acid labile subunit", "type": "recommended", "evidence": [ { "id": "A0AAA9TBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGFALS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6", "locus": { "chromosome": "25", "start_pos": 1366703, "end_pos": 1377301, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033299", "url": "https://www.ensembl.org/id/ENSBTAG00000033299" } ] } } ], "crossref": [ { "id": "A0AAA9TBM6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TBM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24366", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24366", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24366:SF171", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24366:SF171", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SGM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVTHGLVARSLVPSSLWSCTVERAAGLDPEDVPVLPVDVGPASLAHTFRSGQQGLLLTGACRGPGVQLRPGRSRVLLRPESPSWAPPQAPLPAGVPALVVLLVSWAALGPHGLEGVEPVAPADPEGLQCPAVCSCGHDDFTDELSVFCSSRNLTQLPGGLPPGTRALWLDGNNFSSIPAAAFRNLSGLGFLNLQGSGLASLEPQALLGLRGLCHLHLEHNRLHALAAHTFLHTPGLASLGLSNNLLSRLDEGLFRGLAHLWDLNLGWNSLTVLPDTAFQGLAGLRELVLAGNKLAYLQPALFCGLGELRELDLSRNTLRSVKANVFVKLPKLQKLYLDHNLVAAVAPGAFLGMKALRWLDLSHNRVGSLLEDSFPGLLGLHVLRLSHNALAGLRPRTFKDLHFLEELQLGHNRLRQLPEEAFAGLGQLEVLALNDNQLQELRPGGFLGLRNLAVLNLSSNCLRDLPERAFQGLAKLHSLHLEGGCLARLGPLAFAGLSGLRRLFLKGNSIADVDERSLGGLAELLELDLTANQLTHLPGRLFQDLGRLEYLLLARNRLSALPADALGPLQRTFWLDVSHNRLEALPAAALAPLSRLRFLSLRNNSLRTFAPQPPGLERLWLEGNPWDCSCALGALRAFALQQPASVPRFVQALAEGNDDRQPPVLAYNNITCASPPSLAGLDLRDVGEAHFAHC", "length": 695, "header": "tr|A0AAA9TBM6-1|A0AAA9TBM6_BOVIN Isoform 1 of Insulin-like growth factor-binding protein complex acid labile subunit OS=Bos taurus OX=9913 GN=IGFALS PE=4 SV=1 CANONICAL=A0AAA9TBM6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6/entry#A0AAA9SGM3-1", "sequence": { "sequence": "MTQAIHPRGSRGRRGVPALVVLLVSWAALGPHGLEGVEPVAPADPEGLQCPAVCSCGHDDFTDELSVFCSSRNLTQLPGGLPPGTRALWLDGNNFSSIPAAAFRNLSGLGFLNLQGSGLASLEPQALLGLRGLCHLHLEHNRLHALAAHTFLHTPGLASLGLSNNLLSRLDEGLFRGLAHLWDLNLGWNSLTVLPDTAFQGLAGLRELVLAGNKLAYLQPALFCGLGELRELDLSRNTLRSVKANVFVKLPKLQKLYLDHNLVAAVAPGAFLGMKALRWLDLSHNRVGSLLEDSFPGLLGLHVLRLSHNALAGLRPRTFKDLHFLEELQLGHNRLRQLPEEAFAGLGQLEVLALNDNQLQELRPGGFLGLRNLAVLNLSSNCLRDLPERAFQGLAKLHSLHLEGGCLARLGPLAFAGLSGLRRLFLKGNSIADVDERSLGGLAELLELDLTANQLTHLPGRLFQDLGRLEYLLLARNRLSALPADALGPLQRTFWLDVSHNRLEALPAAALAPLSRLRFLSLRNNSLRTFAPQPPGLERLWLEGNPWDCSCALGALRAFALQQPASVPRFVQALAEGNDDRQPPVLAYNNITCASPPSLAGLDLRDVGEAHFAHC", "length": 615, "header": "tr|A0AAA9SGM3-1|A0AAA9TBM6_BOVIN Computationally mapped isoform of Insulin-like growth factor-binding protein complex acid labile subunit OS=Bos taurus OX=9913 GN=IGFALS PE=4 SV=1 CANONICAL=A0AAA9TBM6-1" }, "locus": { "chromosome": "25", "start_pos": 1371512, "end_pos": 1367707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098817.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098817.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082843.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082843.1" } ] } }, { "isoform_ac": "A0AAA9TBM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6/entry#A0AAA9TBM6-1", "sequence": { "sequence": "MRVTHGLVARSLVPSSLWSCTVERAAGLDPEDVPVLPVDVGPASLAHTFRSGQQGLLLTGACRGPGVQLRPGRSRVLLRPESPSWAPPQAPLPAGVPALVVLLVSWAALGPHGLEGVEPVAPADPEGLQCPAVCSCGHDDFTDELSVFCSSRNLTQLPGGLPPGTRALWLDGNNFSSIPAAAFRNLSGLGFLNLQGSGLASLEPQALLGLRGLCHLHLEHNRLHALAAHTFLHTPGLASLGLSNNLLSRLDEGLFRGLAHLWDLNLGWNSLTVLPDTAFQGLAGLRELVLAGNKLAYLQPALFCGLGELRELDLSRNTLRSVKANVFVKLPKLQKLYLDHNLVAAVAPGAFLGMKALRWLDLSHNRVGSLLEDSFPGLLGLHVLRLSHNALAGLRPRTFKDLHFLEELQLGHNRLRQLPEEAFAGLGQLEVLALNDNQLQELRPGGFLGLRNLAVLNLSSNCLRDLPERAFQGLAKLHSLHLEGGCLARLGPLAFAGLSGLRRLFLKGNSIADVDERSLGGLAELLELDLTANQLTHLPGRLFQDLGRLEYLLLARNRLSALPADALGPLQRTFWLDVSHNRLEALPAAALAPLSRLRFLSLRNNSLRTFAPQPPGLERLWLEGNPWDCSCALGALRAFALQQPASVPRFVQALAEGNDDRQPPVLAYNNITCASPPSLAGLDLRDVGEAHFAHC", "length": 695, "header": "tr|A0AAA9TBM6-1|A0AAA9TBM6_BOVIN Isoform 1 of Insulin-like growth factor-binding protein complex acid labile subunit OS=Bos taurus OX=9913 GN=IGFALS PE=4 SV=1 CANONICAL=A0AAA9TBM6-1" }, "locus": { "chromosome": "25", "start_pos": 1369791, "end_pos": 1367707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094084.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094084.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6" } ], "pmid": "" }, { "name": "insulin-like growth factor ternary complex", "id": "GO:0042567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBM6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBM6" } ], "pmid": "" } 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Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. 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Gene", "id": "ENSBTAG00000033180", "url": "https://www.ensembl.org/id/ENSBTAG00000033180" } ] } } ], "crossref": [ { "id": "A0AAA9TB51", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TB51", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd19203", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19203", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616050", "url": "https://www.ncbi.nlm.nih.gov/gene/616050", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12197:SF288", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12197:SF288", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00856", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00856", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "60260", "url": "https://www.rhea-db.org/rhea/60260", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SGZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCSQCRIAKYCSAKCQKKAWQDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMQETPSESEKLYSFYDLESNINKLTEDKKEGLRQLALTFQHFMREEIQDASQLPPSFDIFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVRDVEAGEELTICYLDMLMTSEERRKQLRGQYCFDCDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEDLKAHWKWEQVLAMCQSIISSNAERLPDINIYQLKVLDCAMDACLNLGLLEEALFYGIRTMEPYRIFYPGNHPVRGVQIMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAP", "length": 369, "header": "tr|A0AAA9TB51-1|A0AAA9TB51_BOVIN Isoform 1 of Histone-lysine N-methyltransferase SMYD3 OS=Bos taurus OX=9913 GN=SMYD3 PE=4 SV=1 CANONICAL=A0AAA9TB51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51/entry#A0AAA9SGZ4-1", "sequence": { "sequence": "MEPSKVEKFSTTDKGNGLRALAPLRPGELLFRSDPLAYTVSKGSRGVVCDRCLLGKEKLMRCSQCRIAKYCSAKCQKKAWQDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMQETPSESEKLYSFYDLESNINKLTEDKKEGLRQLALTFQHFMREEIQDASQLPPSFDIFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVRDVEAGEELTICYLDMLMTSEERRKQLRGQYCFDCDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEDLKAHWKWEQVLAMCQSIISSNAERLPDINIYQLKVLDCAMDACLNLGLLEEALFYGIRTMEPYRIFYPGNHPVRGVQIMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAP", "length": 428, "header": "tr|A0AAA9SGZ4-1|A0AAA9TB51_BOVIN Computationally mapped isoform of Histone-lysine N-methyltransferase SMYD3 OS=Bos taurus OX=9913 GN=SMYD3 PE=4 SV=1 CANONICAL=A0AAA9TB51-1" }, "locus": { "chromosome": "16", "start_pos": 31578646, "end_pos": 30839371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098232.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098232.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085471.1" } ] } }, { "isoform_ac": "A0AAA9TB51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51/entry#A0AAA9TB51-1", "sequence": { "sequence": "MRCSQCRIAKYCSAKCQKKAWQDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMQETPSESEKLYSFYDLESNINKLTEDKKEGLRQLALTFQHFMREEIQDASQLPPSFDIFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVRDVEAGEELTICYLDMLMTSEERRKQLRGQYCFDCDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEDLKAHWKWEQVLAMCQSIISSNAERLPDINIYQLKVLDCAMDACLNLGLLEEALFYGIRTMEPYRIFYPGNHPVRGVQIMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAP", "length": 369, "header": "tr|A0AAA9TB51-1|A0AAA9TB51_BOVIN Isoform 1 of Histone-lysine N-methyltransferase SMYD3 OS=Bos taurus OX=9913 GN=SMYD3 PE=4 SV=1 CANONICAL=A0AAA9TB51-1" }, "locus": { "chromosome": "16", "start_pos": 31578646, "end_pos": 31007266, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088395.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088395.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093297.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093297.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "id": "GO:0001162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001162", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "histone H3K36 dimethyltransferase activity", "id": "GO:0140954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "histone H4 methyltransferase activity", "id": "GO:0140939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140939", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" }, { "name": "histone H3K4 trimethyltransferase activity", "id": "GO:0140999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140999", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB51", "url": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DICIHTW", "url": "https://omabrowser.org/oma/group/DICIHTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MST4", "url": "https://www.orthodb.org/?gene=F1MST4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19305", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19305", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19305:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19305:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SH88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST4", "url": "https://www.uniprot.org/uniprotkb/F1MST4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST4-1", "url": "https://www.uniprot.org/uniprotkb/F1MST4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRPAPGTGTACSGFDPASGTPGLQRLSNGAGPESRCFLVFPATQRQSDVGRGANLRRNQMSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHAASGLMDQATHCEPSSGSQEGRPLQLQTSEPVISEEDTQELGQEFHVDVVTFSARRSASKSRVGNSSASGMYLLGLCGQSPCLWPGAGPDSGCIISQQPYLAEDPEEAQRSCVRHRDRAGETG", "length": 512, "header": "tr|A0AAA9TCW8-1|A0AAA9TCW8_BOVIN Isoform 1 of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=1 CANONICAL=A0AAA9TCW8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SH88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8/entry#A0AAA9SH88-1", "sequence": { "sequence": "MSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHADPEEAQRSCVRHRDR", "length": 345, "header": "tr|A0AAA9SH88-1|A0AAA9TCW8_BOVIN Computationally mapped isoform of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=1 CANONICAL=A0AAA9TCW8-1" }, "locus": { "chromosome": "7", "start_pos": 3459488, "end_pos": 3404171, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119046.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119046.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084697.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084697.1" } ] } }, { "isoform_ac": "A0AAA9TCW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8/entry#A0AAA9TCW8-1", "sequence": { "sequence": "MLRPAPGTGTACSGFDPASGTPGLQRLSNGAGPESRCFLVFPATQRQSDVGRGANLRRNQMSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHAASGLMDQATHCEPSSGSQEGRPLQLQTSEPVISEEDTQELGQEFHVDVVTFSARRSASKSRVGNSSASGMYLLGLCGQSPCLWPGAGPDSGCIISQQPYLAEDPEEAQRSCVRHRDRAGETG", "length": 512, "header": "tr|A0AAA9TCW8-1|A0AAA9TCW8_BOVIN Isoform 1 of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=1 CANONICAL=A0AAA9TCW8-1" }, "locus": { "chromosome": "7", "start_pos": 3469381, "end_pos": 3404156, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094701.1" } ] } }, { "isoform_ac": "A0AAA9TEN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8/entry#A0AAA9TEN3-1", "sequence": { "sequence": "MLRPAPGTGTACSGFDPASGTPGLQRLSNGAGPESRCFLVFPATQRQSDVGRGANLRRNQMSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHAASGLMDQATHCEPSSGSQEGRPLQLQTSEPVISEEDTQELGQDPPMGFPSGAVVKNPLANAGDAGSIPGSGRSPGVGNGNPLHILAWEVA", "length": 480, "header": "tr|A0AAA9TEN3-1|A0AAA9TEN3_BOVIN Computationally mapped isoform of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=1 CANONICAL=A0AAA9TCW8-1" }, "locus": { "chromosome": "7", "start_pos": 3469381, "end_pos": 3415732, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104211.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104211.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095432.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095432.1" } ] } }, { "isoform_ac": "A0AAA9TQ50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8/entry#A0AAA9TQ50-1", "sequence": { "sequence": "MLRPAPGTGTACSGFDPASGTPGLQRLSNGAGPESRCFLVFPATQRQSDVGRGANLRRNQMSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHAASGLMDQATHCEPSSGSQEGRPLQLQTSEPVISEEDTQELGQDQNGKLTRLWPYGFSGSSASPAAEQQ", "length": 458, "header": "tr|A0AAA9TQ50-1|A0AAA9TQ50_BOVIN Computationally mapped isoform of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=1 CANONICAL=A0AAA9TCW8-1" }, "locus": { "chromosome": "7", "start_pos": 3469381, "end_pos": 3418659, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110712.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110712.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099153.1" } ] } }, { "isoform_ac": "F1MST4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8/entry#F1MST4-1", "sequence": { "sequence": "MLRPAPGTGTACSGFDPASGTPGLQRLSNGAGPESRCFLVFPATQRQSDVGRGANLRRNQMSGDTCVQTWPCSYYLELEKRWVPGRLSLTSLSLKFMTDKTRETLVSFPLSSIIEIKKEASHFIFSSITILERDHSKHWFSSLQPSRNAVFSVIEHFWRELLLSESGAAAEAASSSMTKGKELTCLMACTQKRLEDTARVLHHQGEQLDGISRGLDKMESDLDVADRLLTELESPSWWPFSSKLWKTPSETKPKWDASMADSKAFGKEGIVIQVPAVISQRTESHVKPGRLTVLVSGLEIYNSDSLLMHRFEREDVDDIKVHTPYEISICQRFIGKPDISYRLISAKMPEVIPILEVQFSKKIELLEVAMMLGSTRTSSLAEKGYSVWHAASGLMDQATHCEPSSGSQEGRPLQLQTSEPVISEEDTQELGQILRKLKGLALDTETELERQDEALDGITEAVDRATLTIDKHNRRMKKLT", "length": 480, "header": "tr|F1MST4-1|F1MST4_BOVIN Computationally mapped isoform of Synaptosomal-associated protein 47 OS=Bos taurus OX=9913 GN=SNAP47 PE=3 SV=2 CANONICAL=A0AAA9TCW8-1" }, "locus": { "chromosome": "7", "start_pos": 3469381, "end_pos": 3404071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005482.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005482.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005482.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005482.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A2P7-1", "protein_name": "Synaptosomal-associated protein 47", "gene_name": "SNAP47", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNEDIRIHSWPCSYYFDTNKQWVSGRLSLTPVAIKFTADKTGEVLVNFHLSSISEIKKESSNLIFSSLTILEKNTKHWFSSLQPSRNAVFNILEHFWREQLLSSEGTGAEAAALQSTKGKELTGLLTGSQKRLEDTAKVLHYQGEQFDNIMRGLNKIEGDMDVADRLLTELESPSWWPFSSKLWKAPLETKPKETATVSDLKNQEGIIIRIPVIITHRTDSNVKPGKLTLFASGLEISDCNSQVIHRFESKDVDDIKVHTPYEISVRQRFIGKPDTSYRLLSARMPEAISVLEMQFSKKIQFLEDALGFVGPRKSPQVDFGTSIWQAATGLLGGVVQPSSPVGGREGTDSDQVQLQKHEKISQEEAKELKQILKKLKSLALETEAELERQDEALDSITTSVDRATLNIDKQNRRIKKLT", "length": 419 }, "evidence": [ { "id": "A0AAA9TCW8", "url": "https://omabrowser.org/oma/group/A0AAA9TCW8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q0P4A7-1", "protein_name": "Synaptosomal-associated protein 47", "gene_name": "snap47", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSQEPSIHTWPGSYYINSEKRWASGVLSLSRTTLRFASEQKQESLMSLKLSRIMEIKMESSSIIFSALTVLEQGNLKHWFGSLRPCRNAVYHVLEHFWRERLLSPSEPQGAEAPLSKGQELISLISGAQRRLEDTGKVLNHQGEQFDNMIQGLDKIESDLTVADKLLSELECPSWWPFSKMPWRSHQEAKSEAAAKAACTKGSGKIQKVIVSIPAIVFRDGNTGNMKPGSLTLLVSSLEVREANGQLLHCFEKEEVDDIHVFNPYEISIRQRFIGKPDICFRLLSARMTEALSVLEMQYKKKVEVTRDYAVFRSTSATTPESPESGGNVWAAGHGQDTEVPVEVPAGELTQLQLQVLQPTVTEAEAQELKQMLQQLKNLALEAETELERQDEALDVLSCSTDHATMNINRHTRRMRKLL", "length": 419 }, "evidence": [ { "id": "A0AAA9TCW8", "url": "https://omabrowser.org/oma/group/A0AAA9TCW8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5SQN1-1", "protein_name": "Synaptosomal-associated protein 47", "gene_name": "SNAP47", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAARRGLHCAGAERPRRRGRLWDSSGVPQRQKRPGPWRTQTQEQMSRDVCIHTWPCTYYLEPKRRWVTGQLSLTSLSLRFMTDSTGEILVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIEHFWRELLLSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESDLEVADRLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVISHRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKPDMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSARTSSPAEKSCSVWHAASGLMGRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRRMKGLALEAESELERQDEALDGVAAAVDRATLTIDKHNRRMKRLT", "length": 464 }, "evidence": [ { "id": "A0AAA9TCW8", "url": "https://omabrowser.org/oma/group/A0AAA9TCW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P6S0-1", "protein_name": "Synaptosomal-associated protein 47", "gene_name": "Snap47", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSDVRVHTWPCSYYLDLEKQWLPGKLTLTPRSLKFSVDKAEEVLVGLPLSSITEIRKETSLFIFSAITVLEKGQAKHWFSSLRPSRNVVFNIIEHFWRELLLSQPGTAANPTSPMTRGQELMGLMASSQRRMEDTAKVLHHQGEQLDSVMRGLEKMESDLDVADRLLTELETPSWWPFSAKFWKTPVEAKPRDSVSVAPCEPFGKEGVVIRVPAVVSQRTESHSKPGKLTVLVSGLEIHDSSSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPDVAYRLISAKMPEVIPILEVQFSKKIELLEDALVLRSRGRASPAEGGCSIRHAASRLMGCTTHQELPTGGQEGQQSQLQKDWPLLSEGEAQELTQILSKLKGLALDTEAELERQDAALDGITVAVDRATLTVDKHNRRMRKLL", "length": 419 }, "evidence": [ { "id": "A0AAA9TCW8", "url": "https://omabrowser.org/oma/group/A0AAA9TCW8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R570-1", "protein_name": "Synaptosomal-associated protein 47", "gene_name": "Snap47", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSDMRVHSWSCSYYLDLEKQWVSGKLTLTPHSLKFIVEKTEEVLVGLPLSSIIEIRKESSLFIFGAITVLEKGQTKHWFSSLQPSRNVVFNVIEHFWRELLLSQPGTAANIPSHVTRGQELIGLMANSQKRMEDTAKDLQQQSEQLDSVLKGLEKMESDLDVADRLLTELETPSWWPFGSKFWKMPAEENLKEGVSSTCEPFGKEGVVITVPAIISERAESHSKLGKLTVLVSALEIYDSCSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPDVAYQLISAKMPEVIPILEVQFSSKIELLEDALVLRNKVFASSAERHAASRPKGCTPHRELPTGGQEGEQLQLQKNLPLFSEGEAQELTQILSKMKGLALDTEAELERQDAALDGITVAVDRATLNVDKQNRRMRKLM", "length": 413 }, "evidence": [ { "id": "A0AAA9TCW8", "url": "https://omabrowser.org/oma/group/A0AAA9TCW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "SNARE complex", "id": "GO:0031201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031201", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "SNAP receptor activity", "id": "GO:0005484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005484", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "synaptic vesicle fusion to presynaptic active zone membrane", "id": "GO:0031629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" }, { "name": "synaptic vesicle priming", "id": "GO:0016082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW8" }, { "id": "PS50192", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "T-SNARE coiled-coil homology", "eco_id": "ECO_0000259", "start_pos": 196, "end_pos": 232, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 21 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 454, "end_pos": 456 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051093", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051093", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SI42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI42-1", "url": 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PE=3 SV=1 CANONICAL=A0AAA9TBA1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1/entry#A0AAA9SI42-1", "sequence": { "sequence": 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OX=9913 GN=LOC100300059 PE=3 SV=1 CANONICAL=A0AAA9TBA1-1" }, "locus": { "chromosome": "X", "start_pos": 136694178, "end_pos": 136395303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104271.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104271.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083413.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083413.1" } ] } }, { "isoform_ac": "A0AAA9TBA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1/entry#A0AAA9TBA1-1", "sequence": { "sequence": "MSRPQGLLWLPLAFTPVCVMVNSNVLLWITALAVKFTVIDSQAQYPVVSTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGVRNATQFAAVCPQHLDERSLLHDMLPVWFTANLDTLMTYMQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYRELIQQTITPATYHISFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDHEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPSKIWPTTKRPAITPANSNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNAANDIAHIQNEEIMSLQMKQLDHECESLQAHDTLRLTCPPDYTLTLRRPPMLAFPGTTRSTFNPTKCETVSIRCHSSAFKTHHHPSRLERDKDVHESRTWAFPTVTVEADTFLELSQGH", "length": 836, "header": "tr|A0AAA9TBA1-1|A0AAA9TBA1_BOVIN Isoform 1 of Carboxylesterase type B domain-containing protein OS=Bos taurus OX=9913 GN=LOC100300059 PE=3 SV=1 CANONICAL=A0AAA9TBA1-1" }, "locus": { "chromosome": "X", "start_pos": 136694567, "end_pos": 136395303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089152.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089152.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093953.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 332, "start_aa": "Thr", "end_pos": 332, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr332", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 642, "start_aa": "Thr", "end_pos": 642, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr642", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "neurexin family protein binding", "id": "GO:0042043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042043", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBA1" }, { "id": "PF00135", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carboxylesterase type B", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 590, "start_aa": "Tyr", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAD1-1", "uniprot_ac": "A0AAA9TAD1", "uniprot_id": "A0AAA9TAD1_BOVIN", "mass": { "chemical_mass": 100607.0, "monoisotopic_mass": 100607.0 }, "refseq": {}, "gene_names": [ { "name": "VPS39", "type": "recommended", "evidence": [ { "id": "A0AAA9TAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ] } ], "protein_names": [ { "name": "VPS39 subunit of HOPS complex", "type": "synonym", "evidence": [ { "id": "A0AAA9TAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1", "locus": { "chromosome": "10", "start_pos": 37550536, "end_pos": 37596984, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032055", "url": "https://www.ensembl.org/id/ENSBTAG00000032055" } ] } } ], "crossref": [ { "id": "A0AAA9TAD1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAD1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032055", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032055", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BM41", "url": "https://www.orthodb.org/?gene=E1BM41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12894", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12894", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12894:SF49", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12894:SF49", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM41", "url": "https://www.uniprot.org/uniprotkb/E1BM41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BM41-1", "url": "https://www.uniprot.org/uniprotkb/E1BM41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHAETGDEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGANKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLVENFKGLAIPYLEHVIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKAPVPAGEEEGELGEYRRKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTRMAEEYCHKHYDQNKDGNKDVYLSLLRMYLSPPSVHCLGPIKLELLEPQANLQAALQVLELHHSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSDMYHGVCESCMWPGGSYLLRIHL", "length": 874, "header": "tr|A0AAA9TAD1-1|A0AAA9TAD1_BOVIN Isoform 1 of VPS39 subunit of HOPS complex OS=Bos taurus OX=9913 GN=VPS39 PE=3 SV=1 CANONICAL=A0AAA9TAD1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1/entry#A0AAA9SIX4-1", "sequence": { "sequence": "MHDAFEPVPILEKLPLQIDCLAAWGCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHAETGDEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGANKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLVENFKGLAIPYLEHVIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKAPVPAGEEEGELGEYRRKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTRMAEEYCHKHYDQNKDGNKDVYLSLLRMYLSPPSVHCLGPIKLELLEPQANLQAALQVLELHHSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT", "length": 853, "header": "tr|A0AAA9SIX4-1|A0AAA9TAD1_BOVIN Computationally mapped isoform of VPS39 subunit of HOPS complex OS=Bos taurus OX=9913 GN=VPS39 PE=3 SV=1 CANONICAL=A0AAA9TAD1-1" }, "locus": { "chromosome": "10", "start_pos": 37596768, "end_pos": 37551919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130804.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130804.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083744.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083744.1" } ] } }, { "isoform_ac": "A0AAA9TAD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1/entry#A0AAA9TAD1-1", "sequence": { "sequence": "MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHAETGDEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGANKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLVENFKGLAIPYLEHVIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKAPVPAGEEEGELGEYRRKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTRMAEEYCHKHYDQNKDGNKDVYLSLLRMYLSPPSVHCLGPIKLELLEPQANLQAALQVLELHHSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSDMYHGVCESCMWPGGSYLLRIHL", "length": 874, "header": "tr|A0AAA9TAD1-1|A0AAA9TAD1_BOVIN Isoform 1 of VPS39 subunit of HOPS complex OS=Bos taurus OX=9913 GN=VPS39 PE=3 SV=1 CANONICAL=A0AAA9TAD1-1" }, "locus": { "chromosome": "10", "start_pos": 37596768, "end_pos": 37552902, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130873.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130873.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094979.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094979.1" } ] } }, { "isoform_ac": "E1BM41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1/entry#E1BM41-1", "sequence": { "sequence": "MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHAETGDEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGANKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLVENFKGLAIPYLEHVIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKAPVPAGEEEGELGEYRRKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHVLKDTRMAEEYCHKHYDQNKDGNKDVYLSLLRMYLSPPSVHCLGPIKLELLEPQANLQAALQVLELHHSKLDTTKAINLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNRQFQRIGYLLGQEEMGKAPSCVCIPVTQIWKLSSVCNPPGGCLFSFLLGCA", "length": 901, "header": "tr|E1BM41-1|E1BM41_BOVIN Computationally mapped isoform of VPS39 subunit of HOPS complex OS=Bos taurus OX=9913 GN=VPS39 PE=3 SV=2 CANONICAL=A0AAA9TAD1-1" }, "locus": { "chromosome": "10", "start_pos": 37596768, "end_pos": 37551540, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006949.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006949.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006949.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006949.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "vacuole fusion", "id": "GO:0097576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "endosomal vesicle fusion", "id": "GO:0034058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034058", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "late endosome to lysosome transport", "id": "GO:1902774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "autophagosome-lysosome fusion", "id": "GO:0061909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "AP-3 adaptor complex", "id": "GO:0030123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030123", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "lysosomal HOPS complex", "id": "GO:1902501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902501", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD1" }, { "id": "PS50219", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50219" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CNH", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 283, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 231, "end_pos": 233 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDB4-1", "uniprot_ac": "A0AAA9TDB4", "uniprot_id": "A0AAA9TDB4_BOVIN", "mass": { "chemical_mass": 132237.0, "monoisotopic_mass": 132237.0 }, "refseq": {}, "gene_names": [ { "name": "RBM20", "type": "recommended", "evidence": [ { "id": "A0AAA9TDB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ] } ], "protein_names": [ { "name": "RNA-binding protein 20", "type": "recommended", "evidence": [ { "id": "A0AAA9TDB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#names_and_taxonomy" } ] }, { "name": "RNA-binding motif protein 20", "type": "synonym", "evidence": [ { "id": "A0AAA9TDB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH. Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts. RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles. RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts. Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4#function" }, { "database": "UniProtKB", "id": "ARBA00057712", "url": "https://www.uniprot.org/uniprotkb/ARBA00057712#function" }, { "database": "UniProtKB", "id": "F1MF93", "url": "https://www.uniprot.org/uniprotkb/F1MF93#function" }, { "database": "UniProtKB", "id": "A0AAA9SJP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP1#function" }, { "database": "UniProtKB", "id": "A0AAA9TH85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH85#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RBM20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4", "locus": { "chromosome": "26", "start_pos": 31396918, "end_pos": 31202434, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023891", "url": "https://www.ensembl.org/id/ENSBTAG00000023891" } ] } } ], "crossref": [ { "id": "A0AAA9TDB4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDB4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023891", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023891", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12685", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12685", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525419", "url": "https://www.ncbi.nlm.nih.gov/gene/525419", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:525419", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525419", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTRADWG", "url": "https://omabrowser.org/oma/group/PTRADWG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF93", "url": "https://www.orthodb.org/?gene=F1MF93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9SJP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF93", "url": "https://www.uniprot.org/uniprotkb/F1MF93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF93-1", "url": "https://www.uniprot.org/uniprotkb/F1MF93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGVPGGFVCTASGGLCWTDSQELLRSQSAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPQHAATVPSTRFPSNALAFSPPGQTRGPGPTVSLPSQPPNAMVMHPFMPQTPTQPAVILGLGKTGPAPAAAGFYEYGKASSGQAYGSETDGQPGFLPASAATSGSVTYEGHYSHSGQDGQAAFPKDFYGPSAQGSQVAGGFVAEPAGALKGEVGPLLQGPNSQWESPHGFSGQSKPDLAAAPSLWPPPPGQPYELYDPEEPTPDRTPPSFGGRLNNSKQGFSGARRRAKEEQAVLSLRPLQAHELNDFHGVAPLHLPHVCSICDKKVFDLKDWELHVKGKLHAQKCLLFSENAGVRCVLGPAEGTLCGSPNSTAVYNPAGTEDYSSNLGTSYAAIPARSFTQSSPAFPSASPGTNFAQRKTGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYREKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREAERSIMRKEAEGSQHCAQGKSLPEGGGRQSLLQDHSGRCAQWWYAPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARRENGEDKRDRTDTWAHDRKHYPRQLDKAELDERLEVGRGYREKHPRSGSPNPLHSASGYKSREDGYHRKESKGKSDKYLKPQQDAPGRSRRKDEARLREGRHPHADDAGREDGLEPKGTKSKQSEKNRAKRSDRDQEGADDRKERMAENEAGKEEQDSMEESPPSVGRQEKETESSDTENRRARKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDRISAEICPCVTTALDLDFTKGFAKEGVKTIGNGAGEISLKSPEELPSASTGCPSDMDVEMPGLNLDAERKPAECETGLSLEGSDCYEKPAKGGESSDVRLAPPLLQMSSPKPAEERAWQPGPFLDDCKARGTPEDGAGEGSPLEEKAGPPTETDLQSQACQGASTPENSRYSEMKSLDVRSLEDAEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETERAGSPRPQDSGIVPHFERKKL", "length": 1214, "header": "tr|A0AAA9TDB4-1|A0AAA9TDB4_BOVIN Isoform 1 of RNA-binding protein 20 OS=Bos taurus OX=9913 GN=RBM20 PE=4 SV=1 CANONICAL=A0AAA9TDB4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#A0AAA9SJP1-1", "sequence": { "sequence": "MNPSGCAGSGRALCGAVCAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPQHAATVPSTRFPSNALAFSPPGQTRGPGPTVSLPSQPPNAMVMHPFMPQTPTQPAVILGLGKTGPAPAAAGFYEYGKASSGQAYGSETDGQPGFLPASAATSGSVTYEGHYSHSGQDGQAAFPKDFYGPSAQGSQVAGGFVAEPAGALKGEVGPLLQGPNSQWESPHGFSGQSKPDLAAAPSLWPPPPGQPYELYDPEEPTPDRTPPSFGGRLNNSKQGFSGARRRAKEEQAVLSLRPLQAHELNDFHGVAPLHLPHVCSICDKKVFDLKDWELHVKGKLHAQKCLLFSENAGVRCVLGPAEGTLCGSPNSTAVYNPAGTEDYSSNLGTSYAAIPARSFTQSSPAFPSASPGTNFAQRKTGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYREKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREAERYAPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARRENGEDKRDRTDTWAHDRKHYPRQLDKAELDERLEVGRGYREKHPRSGSPNPLHSASGYKSREDGYHRKESKGKSDKYLKPQQDAPGRSRRKDEARLREGRHPHADDAGREDGLEPKGTKSKQSEKNRAKRSDRDQEGADDRKERMAENEAGKEEQDSMEESPPSVGRQEKETESSDTENRRARKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDRISAEICPCVTTALDLDFTKGFAKEGVKTIGNGAGEISLKSPEELPSASTGCPSDMDVEMPGLNLDAERKPAECETGLSLEGSDCYEKPAKGGESSDVRLAPPLLQMSSPKPAEERAWQPGPFLDDCKARGTPEDGAGEGSPLEEKAGPPTETDLQSQACQGASTPENSRYSEMKSLDVRSLEDAEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETERAGSPRPQDSGIVPHFERKKL", "length": 1163, "header": "tr|A0AAA9SJP1-1|A0AAA9TDB4_BOVIN Computationally mapped isoform of RNA-binding protein 20 OS=Bos taurus OX=9913 GN=RBM20 PE=4 SV=1 CANONICAL=A0AAA9TDB4-1" }, "locus": { "chromosome": "26", "start_pos": 31396655, "end_pos": 31337204, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086513.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086513.1" } ] } }, { "isoform_ac": "A0AAA9TDB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#A0AAA9TDB4-1", "sequence": { "sequence": "MNGVPGGFVCTASGGLCWTDSQELLRSQSAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPQHAATVPSTRFPSNALAFSPPGQTRGPGPTVSLPSQPPNAMVMHPFMPQTPTQPAVILGLGKTGPAPAAAGFYEYGKASSGQAYGSETDGQPGFLPASAATSGSVTYEGHYSHSGQDGQAAFPKDFYGPSAQGSQVAGGFVAEPAGALKGEVGPLLQGPNSQWESPHGFSGQSKPDLAAAPSLWPPPPGQPYELYDPEEPTPDRTPPSFGGRLNNSKQGFSGARRRAKEEQAVLSLRPLQAHELNDFHGVAPLHLPHVCSICDKKVFDLKDWELHVKGKLHAQKCLLFSENAGVRCVLGPAEGTLCGSPNSTAVYNPAGTEDYSSNLGTSYAAIPARSFTQSSPAFPSASPGTNFAQRKTGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYREKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREAERSIMRKEAEGSQHCAQGKSLPEGGGRQSLLQDHSGRCAQWWYAPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARRENGEDKRDRTDTWAHDRKHYPRQLDKAELDERLEVGRGYREKHPRSGSPNPLHSASGYKSREDGYHRKESKGKSDKYLKPQQDAPGRSRRKDEARLREGRHPHADDAGREDGLEPKGTKSKQSEKNRAKRSDRDQEGADDRKERMAENEAGKEEQDSMEESPPSVGRQEKETESSDTENRRARKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDRISAEICPCVTTALDLDFTKGFAKEGVKTIGNGAGEISLKSPEELPSASTGCPSDMDVEMPGLNLDAERKPAECETGLSLEGSDCYEKPAKGGESSDVRLAPPLLQMSSPKPAEERAWQPGPFLDDCKARGTPEDGAGEGSPLEEKAGPPTETDLQSQACQGASTPENSRYSEMKSLDVRSLEDAEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETERAGSPRPQDSGIVPHFERKKL", "length": 1214, "header": "tr|A0AAA9TDB4-1|A0AAA9TDB4_BOVIN Isoform 1 of RNA-binding protein 20 OS=Bos taurus OX=9913 GN=RBM20 PE=4 SV=1 CANONICAL=A0AAA9TDB4-1" }, "locus": { "chromosome": "26", "start_pos": 31396655, "end_pos": 31303417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126983.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126983.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096110.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096110.1" } ] } }, { "isoform_ac": "A0AAA9TH85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#A0AAA9TH85-1", "sequence": { "sequence": "MTPGFGGLSAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPQHAATVPSTRFPSNALAFSPPGQTRGPGPTVSLPSQPPNAMVMHPFMPQTPTQPAVILGLGKTGPAPAAAGFYEYGKASSGQAYGSETDGQPGFLPASAATSGSVTYEGHYSHSGQDGQAAFPKDFYGPSAQGSQVAGGFVAEPAGALKGEVGPLLQGPNSQWESPHGFSGQSKPDLAAAPSLWPPPPGQPYELYDPEEPTPDRTPPSFGGRLNNSKQGFSGARRRAKEEQAVLSLRPLQAHELNDFHGVAPLHLPHVCSICDKKVFDLKDWELHVKGKLHAQKCLLFSENAGVRCVLGPAEGTLCGSPNSTAVYNPAGTEDYSSNLGTSYAAIPARSFTQSSPAFPSASPGTNFAQRKTGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYREKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREAERSIMRKEAEGSQHCAQGKSLPEGGGRQSLLQDHSGRCAQWWYAPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARRENGEDKRDRTDTWAHDRKHYPRQLDKAELDERLEVGRGYREKHPRSGSPNPLHSASGYKSREDGYHRKESKGKSDKYLKPQQDAPGRSRRKDEARLREGRHPHADDAGREDGLEPKGTKSKQSEKNRAKRSDRDQEGADDRKERMAENEAGKEEQDSMEESPPSVGRQEKETESSDTENRRARKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDRISAEICPCVTTALDLDFTKGFAKEGVKTIGNGAGEISLKSPEELPSASTGCPSDMDVEMPGLNLDAERKPAECETGLSLEGSDCYEKPAKGGESSDVRLAPPLLQMSSPKPAEERAWQPGPFLDDCKARGTPEDGAGEGSPLEEKAGPPTETDLQSQACQGASTPENSRYSEMKSLDVRSLEDAEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETERAGSPRPQDSGIVPHFERKKL", "length": 1194, "header": "tr|A0AAA9TH85-1|A0AAA9TH85_BOVIN Computationally mapped isoform of RNA-binding protein 20 OS=Bos taurus OX=9913 GN=RBM20 PE=4 SV=1 CANONICAL=A0AAA9TDB4-1" }, "locus": { "chromosome": "26", "start_pos": 31396655, "end_pos": 31325300, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100926.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100926.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096425.1" } ] } }, { "isoform_ac": "F1MF93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4/entry#F1MF93-1", "sequence": { "sequence": "MVLAAAMSQDAEPSGPEQPDRDARSVPGAPAPPAPPAPPGPRGMQPPPPPPPPPPQASLPQIIQNAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPQHAATVPSTRFPSNALAFSPPGQTRGPGPTVSLPSQPPNAMVMHPFMPQTPTQPAVILGLGKTGPAPAAAGFYEYGKASSGQAYGSETDGQPGFLPASAATSGSVTYEGHYSHSGQDGQAAFPKDFYGPSAQGSQVAGGFVAEPAGALKGEVGPLLQGPNSQWESPHGFSGQSKPDLAAAPSLWPPPPGQPYELYDPEEPTPDRTPPSFGGRLNNSKQGFSGARRRAKEEQAVLSLRPLQAHELNDFHGVAPLHLPHVCSICDKKVFDLKDWELHVKGKLHAQKCLLFSENAGVRCVLGPAEGTLCGSPNSTAVYNPAGTEDYSSNLGTSYAAIPARSFTQSSPAFPSASPGTNFAQRKTGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYREKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREAERYAPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARRENGEDKRDRTDTWAHDRKHYPRQLDKAELDERLEVGRGYREKHPRSGSPNPLHSASGYKSREDGYHRKESKGKSDKYLKPQQDAPGRSRRKDEARLREGRHPHADDAGREDGLEPKGTKSKQSEKNRAKRSDRDQEGADDRKERMAENEAGKEEQDSMEESPPSVGRQEKETESSDTENRRARKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDRISAEICPCVTTALDLDFTKGFAKEGVKTIGNGAGEISLKSPEELPSASTGCPSDMDVEMPGLNLDAERKPAECETGLSLEGSDCYEKPAKGGESSDVRLAPPLLQMSSPKPAEERAWQPGPFLDDCKARGTPEDGAGEGSPLEEKAGPPTETDLQSQACQGASTPENSRYSEMKSLDVRSLEDAEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETERAGSPRPQDSGIVPHFERKKL", "length": 1210, "header": "tr|F1MF93-1|A0AAA9TDB4_BOVIN Computationally mapped isoform of RNA-binding protein 20 OS=Bos taurus OX=9913 GN=RBM20 PE=4 SV=3 CANONICAL=A0AAA9TDB4-1" }, "locus": { "chromosome": "26", "start_pos": 31396655, "end_pos": 31202529, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046225.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046225.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043544.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043544.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 148, "start_aa": "Thr", "end_pos": 148, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr148", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 319, "start_aa": "Thr", "end_pos": 319, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr319", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:525419", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:525419", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9PT37-1", "protein_name": "RNA-binding protein 20", "gene_name": "Rbm20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVLAAAMSQDADPSGPEQPDRDACIVPGVQGPPAPQGQQGMQPLPPPLPPPPQPQSSLPQIIQNAAKLLDKNPFSVSSQNPLLTSPASVQLAQIQAQLTLHRLKMAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVLGTTHGPTGVSQHAATVPSAHFPSTAIAFSPPSQAGGPGPSVSLPSQPPNAMVVHTFSGVVPQTPAQPAVILSIGKAGPTPATTGFYDYGKANPGQAYGSETEGQPGFLPASASAAASGGVTYEGHYSHTGQDGQATFSKDFYGPSAQGSHAAGGFPADQAGSMKGDVGGLLQGTNSQWERPSGFSGQNKADITAGPGLWAPPASQPYELYDPEEPTSDRAPPAFGSRLNNSKQGFNCSCRRTKEGQAMLSVRPLQGHQLNDFRGLAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLLFSESAGLRSICATGEGTLSASANSTAVYNPTGNEDYTSTLGTSYAAIPTRAFAQSNPMFPSASSGTNFAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKPALINGEKLLIRMSTRYKELQLKKPGKNVAAIIQDIHSQRERCMLREADRYGPERPRSRSPMSRSLSPRSHSPPGPSRADWGNGRDSYAWRDEDRETVPRRENGEDKRDRLDVWAHDRKHYPRQLDKAELDERLEGGRGYREKYLKSGSPGPLHSASGYKGREDGYHRKETKAKLDKHPKQQQQDVPGRSRRKEEARLREPRHPHPEDSGKEEDLEPKVTRAPEGTKSKQSEKSKTKRADRDQEGADDKKEGRGAENEAGTEEQEGMEESPASVGTQQEGTESSDPENTRTKKGQDCDSGSEPEGDNWYPTNMEELVTVDEVGEEDFIMEPDIPELEEIVPIDQKDKILPEICPCVTATLGLDLAKDFTKQGETLGNGDAELSPKLPGQVPSTSTSCPNDTDMEMAGLNLDAERKPAESETGLSPEVSNCYEKEARGAEGSDVRLAPAAQRMSSPQPADERAQQSSPFLDDCKARGSPEDGPHEVSPLEEKASPTTESDLQSQACQENSRYTETRSLNSRSPEFTEAELKEPLSLPSWEPEVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEAAKVSHCRSTVHYRNLQKYLSQLAEEGLKETEGVDSPSPERSGIGPHLERKKL", "length": 1207 }, "evidence": [ { "id": "A0AAA9TDB4", "url": "https://omabrowser.org/oma/group/A0AAA9TDB4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UQS8-1", "protein_name": "RNA-binding protein 20", "gene_name": "Rbm20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLAVAMSQDADPSGPEQPDRDACVMPGVQGPSVPQGQQGMQPLPPPPPPQPQASLPQIIQNAAKLLDKSPFSVNNQNPLLTSPASVQLAQIQAQLTLHRLKMAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVLGTAHGPTGVSQHAASVPSAHFPSTAIAFSPPSQTGGPGPSVSLPSQPPNAMVVHTFSGVVPQTPAQPAVILSLGKAGPTPATTGFYDYGKANSGQAYGSETEGQPGFLPASASATASGSMTYEGHYSHTGQDGQPAFSKDFYGPNAQGPHIAGGFPADQTGSMKGDVGGLLQGTNSQWERPPGFSGQNKPDITAGPSLWAPPASQPYELYDPEEPTSDRAPPAFGSRLNNSKQGFGCSCRRTKEGQAVLSVRPLQGHQLNDFRGLAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLLFSESAGLRSIRASGEGTLSASANSTAVYNPTGNEDYTSNLGTSYAAIPTRAFAQSNPVFPSASSGTSFAAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKPAIINGEKLLIRMSTRYKELQLKKPGKNVAAIIQDIHSQRERDMLREADRYGPERPRSRSPMSRSLSPRSHSPPGPSRADWGNGRDSYAWRDEDRETVPRRENGEDKRDRLDVWAHDRKHYPRQLDKAELDERLEGGRGYREKYLKSGSPGPLHSVSGYKGREDGYHRKEPKAKLDKYPKQQPDVPGRSRRKEEARLREPRHPHPEDSGKAEDLEPKITRAPDGTKSKQSEKSKTKRADRDQEGADDKKESQLAENEAGAEEQEGMVGIQQEGTESCDPENTRTKKGQDCDSGSEPEGDNWYPTNMEELVTVDEVGEEDFIMEPDLPELEEIVPIDQKDKTLPKICTCVTATLGLDLAKDFTKQGETLGNGDAELSLKLPGQVPSTSASCPNDTDLEMPGLNLDAERKPAESETGLSLEVSNCYEKEARGEEDSDVSLAPAVQQMSSPQPADERARQSSPFLDDCKARGSPEDGSHEASPLEGKASPPTESDLQSQACRENPRYMEVKSLNVRSPEFTEAELKEPLSLPSWEPEVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEAAKVSHCRSTVHYRNLQKYLSQLAEEGLKETEGTDSPSPERGGIGPHLERKKL", "length": 1199 }, "evidence": [ { "id": "A0AAA9TDB4", "url": "https://omabrowser.org/oma/group/A0AAA9TDB4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5T481-1", "protein_name": "RNA-binding protein 20", "gene_name": "RBM20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVLAAAMSQDADPSGPEQPDRVACSVPGARASPAPSGPRGMQQPPPPPQPPPPPQAGLPQIIQNAAKLLDKNPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSVITGPHGHAGVPQHAAAIPSTRFPSNAIAFSPPSQTRGPGPSMNLPNQPPSAMVMHPFTGVMPQTPGQPAVILGIGKTGPAPATAGFYEYGKASSGQTYGPETDGQPGFLPSSASTSGSVTYEGHYSHTGQDGQAAFSKDFYGPNSQGSHVASGFPAEQAGGLKSEVGPLLQGTNSQWESPHGFSGQSKPDLTAGPMWPPPHNQPYELYDPEEPTSDRTPPSFGGRLNNSKQGFIGAGRRAKEDQALLSVRPLQAHELNDFHGVAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLVFSENAGIRCILGSAEGTLCASPNSTAVYNPAGNEDYASNLGTSYVPIPARSFTQSSPTFPLASVGTTFAQRKGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKSAVINGEKLLIRMSKRYKELQLKKPGKAVAAIIQDIHSQRERDMFREADRYGPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARREEERDPAPWRDNGDDKRDRMDPWAHDRKHHPRQLDKAELDERPEGGRPHREKYPRSGSPNLPHSVSSYKSREDGYYRKEPKAKSDKYLKQQQDAPGRSRRKDEARLRESRHPHPDDSGKEDGLGPKVTRAPEGAKAKQNEKNKTKRTDRDQEGADDRKENTMAENEAGKEEQEGMEESPQSVGRQEKEAEFSDPENTRTKKEQDWESESEAEGESWYPTNMEELVTVDEVGEEEDFIVEPDIPELEEIVPIDQKDKICPETCLCVTTTLDLDLAQDFPKEGVKAVGNGAAEISLKSPRELPSASTSCPSDMDVEMPGLNLDAERKPAESETGLSLEDSDCYEKEAKGVESSDVHPAPTVQQMSSPKPAEERARQPSPFVDDCKTRGTPEDGACEGSPLEEKASPPIETDLQNQACQEVLTPENSRYVEMKSLEVRSPEYTEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEETAKMSHCRSAVHYRNLQKYLSQLAEEGLKETEGADSPRPEDSGIVPRFERKKL", "length": 1227 }, "evidence": [ { "id": "A0AAA9TDB4", "url": "https://omabrowser.org/oma/group/A0AAA9TDB4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "pre-mRNA intronic binding", "id": "GO:0097157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097157", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "splicing factor binding", "id": "GO:1990935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "regulation of mRNA splicing, via spliceosome", "id": "GO:0048024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048024", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "heart formation", "id": "GO:0060914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060914", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "positive regulation of RNA splicing", "id": "GO:0033120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033120", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "negative regulation of mRNA splicing, via spliceosome", "id": "GO:0048025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "spliceosome-depend formation of circular RNA", "id": "GO:0160091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" }, { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDB4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" }, { "id": "PS50171", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Matrin-type", "eco_id": "ECO_0000259", "start_pos": 1148, "end_pos": 1179, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TDB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB4" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 482, "end_pos": 557, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 148, 319 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 332, "end_pos": 334 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], 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"url": "https://www.ensembl.org/id/ENSBTAP00000017097.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540945", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540945", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCH1" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCH1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "chromatin organization", "id": 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"MNGHGVGRAPGYSLNGAGEFYCEAVEGAQNPGGLLLSPAAFINPAQYASVLEGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2392, "header": "tr|A0AAA9TB55-1|A0AAA9TB55_BOVIN Isoform 1 of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0A3Q1LWU2-1", "sequence": { "sequence": "MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVLCRPCRSRVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHPRGHWAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2380, "header": "tr|A0A3Q1LWU2-1|A0A3Q1LWU2_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44746745, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086896.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086896.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061713.1" } ] } }, { "isoform_ac": "A0AAA9SLH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0AAA9SLH5-1", "sequence": { "sequence": "MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVLCRPCRSRVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2394, "header": "tr|A0AAA9SLH5-1|A0AAA9TB55_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44746745, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123030.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123030.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087223.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087223.1" } ] } }, { "isoform_ac": "A0AAA9SYH8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0AAA9SYH8-1", "sequence": { "sequence": "MNGHGVGRAPGYSLNGAGEFYCEAVEGAQNPGGLLLSPAAFINPAQYASVLEGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2321, "header": "tr|A0AAA9SYH8-1|A0AAA9TB55_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44743952, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111828.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111828.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089307.1" } ] } }, { "isoform_ac": "A0AAA9T0Y4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0AAA9T0Y4-1", "sequence": { "sequence": "MFWTPDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2338, "header": "tr|A0AAA9T0Y4-1|A0AAA9TB55_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44743176, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091251.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091251.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090019.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090019.1" } ] } }, { "isoform_ac": "A0AAA9TB55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0AAA9TB55-1", "sequence": { "sequence": "MNGHGVGRAPGYSLNGAGEFYCEAVEGAQNPGGLLLSPAAFINPAQYASVLEGRFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2392, "header": "tr|A0AAA9TB55-1|A0AAA9TB55_BOVIN Isoform 1 of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44743952, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132429.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132429.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095224.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095224.1" } ] } }, { "isoform_ac": "A0AAA9TLS4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#A0AAA9TLS4-1", "sequence": { "sequence": "MLAHSFNISLLNSYHTRKIQRSRRPPTTMSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEEQEKERKRKREEEERRKLPPPPEPPASPPEGHLVDSHMAPATARDGVHPRLPASVNGVCTDAEGPQPLMEQQRLEQGGLPEGPGSGAGDEANGPRGEKQARTQGPTPPIMPQSRSSESARVATLPTRGPELSAQEQMEGLLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPAVPSATRGMTRAMTMPPVSPAGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2413, "header": "tr|A0AAA9TLS4-1|A0AAA9TLS4_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=1 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44751082, "end_pos": 44713355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129631.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129631.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098178.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098178.1" } ] } }, { "isoform_ac": "E1BMN5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55/entry#E1BMN5-1", "sequence": { "sequence": "MLAHSFNISLLNSYHTRKIQRSRRPPTTMSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVNNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVSRLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYKPCDPQLVSERVAALEKSYESLCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGAGQAAARTAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRGHRPTLDALREQAAALPLALSRAPEVQGRVPALQRHYEELRARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARITAVNDIAEQLLKANPPGKDSIVNTQKQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAPAINARLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTSVASEEGPATLPEAEALLAQHAALRGEVERARSEYSQLRAVGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADATIKKLEDFMSTMEANGERIRGLLEAGRQLVSEGNVHAEKIQEKADSVERRHKKNQEAVQQLLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVWEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMEERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLTERQRTLGVAAAGPELAELQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPENTRLSIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDGANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAHELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAFEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGVNLQMDAQERPRDVSSADLVIKNHQGIKAEIEARADRFSSCVDMGQGLLARSHYAAEEISEKLSQLQARRQETADKWQEKMDWLQLVLEVLVFGRDAGVAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTANFLAAGGTGEGAEKKEGGRGTEEAAPSSRTPGQSSRRAPGGQPHGPCHCPGRSAPPPAGQCERRLHRCRGPPAPDGTAET", "length": 2185, "header": "tr|E1BMN5-1|E1BMN5_BOVIN Computationally mapped isoform of Spectrin beta chain OS=Bos taurus OX=9913 GN=SPTBN2 PE=1 SV=4 CANONICAL=A0AAA9TB55-1" }, "locus": { "chromosome": "29", "start_pos": 44751082, "end_pos": 44715558, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007787.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007787.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007787.7", "url": "https://www.ensembl.org/id/ENSBTAP00000007787.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2192, "start_aa": "Thr", "end_pos": 2192, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2192", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:132344210", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132344210", "resource": "KEGG Pathway" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-375165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375165", "resource": "Reactome", "description": "NCAM signaling for neurite out-growth" }, { "id": "R-BTA-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AB32TRJ9-1", "protein_name": "Spectrin beta chain", "gene_name": "sptbn2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTISPTDFDSVEIQQQYNDINNRWDIAAETEWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLGRVTCRIGDLYTDLRDGRMLIRLLEVLSGEQLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRSDLIDFDNLKRSNAHYNLQNAFNVAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDYAIEADQLIEKYETLASELLQWIEQTIVTLNDRQLANSLSAVQNQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEMLAARFDRKAAMRETWLSENQRLVSQDNFGVELGAVEAATRKHEAIETDIQAYGERVAAVEAVARELEAEGYHEVRRVLARRDNVLRLWEYLKELLAARRERLMAHRDLQRLLQELSYIMEWMEDMKSRLQSQDSGKHLHDVEDLLQKHTLVEADISAQAERVKAVQATAKRFASNEQSYKPCDPALVEEKVDLLGRAYGELGQLAADRRVRLDDSRRLWQFLWELGEEAAWIREQEQIISGGDYGKDLSSALHLLSKHEAFRDEMAARYGPLGNSIAGGEALVKEGHVGAPEVTERIKDVRAQWSHLEEASQLREQRLNESVAFHQFQTDANDMEAWILETLRQVSSQEVGHDEFSTQTLARKQREVEEEIQSHRSLIDSLHEQGSLLPEAYAHSPQVEGRLPAIEQRYEELEGLSSSWRQALDGALALYRMFSEASACQLWVGEKEQWLHNMEIPTKLEDLEVIQQRFDTLEPEMNTLGGRISDVNQVAQQLLGSDNRNKDQIDQTQNQLNNRWSDFQSLANQRKQALESALNIQNYHLECNEIKSWMKEKTKVIESTQSLGNDLAGVMALQRKLTGMERDLEAIQGKLDDLRSEAKKLVSEHPEQEEEIKGQLAEIQEVWEELRATMKRREESLGEASKLQGFLRDLDDFQAWLSRTQTTVASEDTPTSLAEAERLLAQHEAIKNEVDNYKEDYEKMRATGAEVTQGQTDAQHMFLAQRLQALDTGWHELRRMWESRHCVLAQAFDFQTLLRDAKQAEGFLNSQEYVLSHTEMPSSLQGAEEAIKKHEDFLTTMEASEEKINGVVESGRRLVSDGNTYADKIQEKTDSIQERHQKNKQAANELLAKLKDNRELQHFLQDGQELTLWINEKMLTAQDMSYDEARNLHSKWQKHQAFMAELASNKDWLDKIDKEGQVLVKEKPELEQTVSETLSGLQKQWVELENTTQAKAQCLFDANRAELFTQSCSALDSWLQNISSQLQSDDFGKDLTSVNILLKKHQMLEHQMDVREKEVQSLQSQALALAQEDSGIVEVDGEQRRVTDRFSQLQDPLKERRQHLLASKEAHQFNRDLEDEILWVKERMPLATSTDHGKDLPSVQLLMKKNQTLQKEIQGHQPRIDDIQAHGTNMSPGKESEMDRERRAALDGRLAELRELWALLISETEQRNVRLAEANRAQQFYTDAAEAEAWMGEQELHMMSEEKAKDEQSALVMVKKHQILEQALEDYAQTIHQLANSSRLMVNSEHPESERITLRQAQVDKLYAGLKDLAEERRGKLQERLRLTQLKREVDDLEQWIAEREVVAGSHELGQDYEHVTMLRDKFREFARDTSTIGQERVDAVNAQADELIESGHPENASVAEWKDGLNEAWADLLELIDTRTQMLAASYELHRFHQDAREALGLIREKKETLAGAELGRDLNTVQHFLRQHTAYEHDVQALSGQVTQVQDDAARLQKAYAGEKADDIHRHERAVTEAWEGLQSATQTRRLLLLDTVEKFRFLNMVRDLMLWMEGINLQIQSHDSPRDVSSAGLVIANHQDIKSEIETRADSFTACSEMGRTLINNNHYASDEIQEKLDQLQAKRTEINQKWQEKMDHLQIVLEVLQFGRDASMAESWLAGQEPLVRAAELGSNVDEVESLIKRHEAFEKLAAGWEDRFSQLEKLTTLEEQEIQRRREEEERARRPPTPPPVEEVVQSEINDSAARTSLDQTTLNQSVSVNGVYSDQDTSQSLSVSVSELKKAEPKPQSNPVSKPVAKPHKAQERFHRIFLYAKGSESESVNGPGRDSGLDSASRQDPSATLPGRGGAEGTTEAMEGILCRKQEMESHNKKSANRSWQNVYCVLRKGSLGFYKDNKSASNGIPYHGEVPISLGEAVCEVAHDYKKRKHVFKLRLGDGKEYLFQAKDDAEMSSWIRAIQSSMSSSERSPGASRGLSRAMTMPPMSPSSGEAGGVTMRNKDGKERDREKRFSFFGKKK", "length": 2398 }, "evidence": [ { "id": "A0AAA9TB55", "url": "https://omabrowser.org/oma/group/A0AAA9TB55/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O15020-1", "protein_name": "Spectrin beta chain, non-erythrocytic 2", "gene_name": "SPTBN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK", "length": 2390 }, "evidence": [ { "id": "A0AAA9TB55", "url": "https://omabrowser.org/oma/group/A0AAA9TB55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q00963-1", "protein_name": "Spectrin beta chain", "gene_name": "beta-Spec", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTTDISIVRWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDVGASHDDSERGGTPGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLPATSQKDEPKRRSFFTLKKK", "length": 2291 }, "evidence": [ { "id": "A0AAA9TB55", "url": "https://omabrowser.org/oma/group/A0AAA9TB55/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9QWN8-1", "protein_name": "Spectrin beta chain, non-erythrocytic 2", "gene_name": "Sptbn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAEHLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARRERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCDPGKEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAETGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQALARQHRALEEEIRAHRPTLDALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAGERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYFLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLLEAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEREMAVREKEVEAIQAQAKALAQEDQSAGEVERTSRAVEEKFRALCQPMKDRCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSACIDMGQELLARNHYAAEEISEKLSQLQSRRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKLTALEERENEQKRKREEEERRKQPPTSEPMASQPEGSLVDGQRVLDTAWDGTQSKLPPSTQAPSINGVCTDTESSQPLLEQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSESAHVATLPARGAELSAQEQMEGTLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSASRGLTRAMTMPPVSQPEGSIVLRSKDGREREREKRFSFFKKNK", "length": 2388 }, "evidence": [ { "id": "A0AAA9TB55", "url": "https://omabrowser.org/oma/group/A0AAA9TB55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "structural constituent of postsynapse", "id": "GO:0099186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "structural constituent of synapse", "id": "GO:0098918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098918", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "spectrin", "id": "GO:0008091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "paranodal junction", "id": "GO:0033010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "postsynaptic spectrin-associated cytoskeleton", "id": "GO:0099189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099189", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "parallel fiber to Purkinje cell synapse", "id": "GO:0098688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098688", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "actin filament capping", "id": "GO:0051693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "regulation of postsynaptic specialization assembly", "id": "GO:0099150", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099150", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1537, "end_pos": 1539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2242, "end_pos": 2244, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 168, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB55" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 2220, "end_pos": 2330, "start_aa": "Gln", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2192 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1537, "end_pos": 1539 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 2242, "end_pos": 2244 }, { "start_pos": 515, "end_pos": 517 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "A0AAA9T9X9", "uniprot_id": "A0AAA9T9X9_BOVIN", "mass": { "chemical_mass": 32175.0, "monoisotopic_mass": 32175.0 }, "refseq": {}, "gene_names": [ { "name": "DIABLO", "type": "recommended", "evidence": [ { "id": "A0AAA9T9X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ] } ], "protein_names": [ { "name": "Diablo IAP-binding mitochondrial protein", "type": "recommended", "evidence": [ { "id": "A0AAA9T9X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#names_and_taxonomy" } ] }, { "name": "Diablo homolog, mitochondrial", "type": "synonym", "evidence": [ { "id": "A0AAA9T9X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#names_and_taxonomy" } ] }, { "name": "Direct IAP-binding protein with low pI", "type": "synonym", "evidence": [ { "id": "A0AAA9T9X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ0#function" }, { "database": "UniProtKB", "id": "ARBA00057426", "url": "https://www.uniprot.org/uniprotkb/ARBA00057426#function" }, { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9#function" }, { "database": "UniProtKB", "id": "F6PXV2", "url": "https://www.uniprot.org/uniprotkb/F6PXV2#function" }, { "database": "UniProtKB", "id": "A0AAA9TQZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIABLO", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9", "locus": { "chromosome": "17", "start_pos": 53173948, "end_pos": 53156133, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004199", "url": "https://www.ensembl.org/id/ENSBTAG00000004199" } ] } } ], "crossref": [ { "id": "A0AAA9T9X9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9X9", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR009062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015142", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015142", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR32247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32247:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32247:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXV2", "url": "https://www.uniprot.org/uniprotkb/F6PXV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PXV2-1", "url": "https://www.uniprot.org/uniprotkb/F6PXV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAALRSWLSRSVSSLFRYRCGRVGGQGRTESGNSGSAVTRLQPRRCGLALRFSAERVTASRPSRRYRQCVPVVANFKKRCFSELIRPWHKTVAVGFGVTLCAVPIAQKPEPHSLSNDTLMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARSHIQLVKSQVQEVRQLSQKAETKLAEAQTEELRQKTQEDGSERAEPEEQEAYLRED", "length": 286, "header": "tr|A0AAA9T9X9-1|A0AAA9T9X9_BOVIN Isoform 1 of Diablo IAP-binding mitochondrial protein OS=Bos taurus OX=9913 GN=DIABLO PE=3 SV=1 CANONICAL=A0AAA9T9X9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#A0AAA9SMQ0-1", "sequence": { "sequence": "MAALRSWLSRSVSSLFRYRQCVPVVANFKKRCFSELIRPWHKTVAVGFGVTLCAVPIAQKPEPHSLSNDTLMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTAKTWKQPKYPSADDWRKKMGVHVHNGLLLGRKKERMPFAATWMQLEISY", "length": 221, "header": "tr|A0AAA9SMQ0-1|A0AAA9T9X9_BOVIN Computationally mapped isoform of Diablo IAP-binding mitochondrial protein OS=Bos taurus OX=9913 GN=DIABLO PE=3 SV=1 CANONICAL=A0AAA9T9X9-1" }, "locus": { "chromosome": "17", "start_pos": 53171566, "end_pos": 53156332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102213.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102213.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085245.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085245.1" } ] } }, { "isoform_ac": "A0AAA9T9X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#A0AAA9T9X9-1", "sequence": { "sequence": "MAALRSWLSRSVSSLFRYRCGRVGGQGRTESGNSGSAVTRLQPRRCGLALRFSAERVTASRPSRRYRQCVPVVANFKKRCFSELIRPWHKTVAVGFGVTLCAVPIAQKPEPHSLSNDTLMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARSHIQLVKSQVQEVRQLSQKAETKLAEAQTEELRQKTQEDGSERAEPEEQEAYLRED", "length": 286, "header": "tr|A0AAA9T9X9-1|A0AAA9T9X9_BOVIN Isoform 1 of Diablo IAP-binding mitochondrial protein OS=Bos taurus OX=9913 GN=DIABLO PE=3 SV=1 CANONICAL=A0AAA9T9X9-1" }, "locus": { "chromosome": "17", "start_pos": 53173288, "end_pos": 53156332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126769.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126769.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094825.1" } ] } }, { "isoform_ac": "A0AAA9TQZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#A0AAA9TQZ7-1", "sequence": { "sequence": "MAALRSWLSRSVSSLFRYRQCVPVVANFKKRCFSELIRPWHKTVAVGFGVTLCAVPIAQKPEPHSLSNDTLMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTVFQLCPTLCNPVDCNPPGSSVHGILQARMQEWEAILLQGIFPIQGSNPLVSCIAGRFLTF", "length": 232, "header": "tr|A0AAA9TQZ7-1|A0AAA9TQZ7_BOVIN Computationally mapped isoform of Diablo IAP-binding mitochondrial protein OS=Bos taurus OX=9913 GN=DIABLO PE=3 SV=2 CANONICAL=A0AAA9T9X9-1" }, "locus": { "chromosome": "17", "start_pos": 53165269, "end_pos": 53156332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092927.2", "url": "https://www.ensembl.org/id/ENSBTAT00000092927.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099754.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099754.2" } ] } }, { "isoform_ac": "F6PXV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9/entry#F6PXV2-1", "sequence": { "sequence": "MAALRSWLSRSVSSLFRYRQCVPVVANFKKRCFSELIRPWHKTVAVGFGVTLCAVPIAQAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARSHIQLVKSQVQEVRQLSQKAETKLAEAQTEELRQKTQEDGSERAEPEEQEAYLRED", "length": 194, "header": "tr|F6PXV2-1|F6PXV2_BOVIN Computationally mapped isoform of Diablo IAP-binding mitochondrial protein OS=Bos taurus OX=9913 GN=DIABLO PE=3 SV=1 CANONICAL=A0AAA9T9X9-1" }, "locus": { "chromosome": "17", "start_pos": 53173288, "end_pos": 53156332, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005496.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005496.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005496.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005496.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" }, { "name": "CD40 receptor complex", "id": "GO:0035631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway", "id": "GO:0097193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9X9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TB71-1", "uniprot_ac": "A0AAA9TB71", "uniprot_id": "A0AAA9TB71_BOVIN", "mass": { "chemical_mass": 234182.0, "monoisotopic_mass": 234182.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF638", "type": "recommended", "evidence": [ { "id": "A0AAA9TB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ] } ], "protein_names": [ { "name": "Zinc finger protein 638", "type": "synonym", "evidence": [ { "id": "A0AAA9TB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF638", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71", "locus": { "chromosome": "11", "start_pos": 13150491, "end_pos": 13299962, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009242", "url": "https://www.ensembl.org/id/ENSBTAG00000009242" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517669", "url": "https://www.ncbi.nlm.nih.gov/gene/517669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJV5", "url": "https://www.orthodb.org/?gene=E1BJV5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15592", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15592", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SN30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV5", "url": "https://www.uniprot.org/uniprotkb/E1BJV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJV5-1", "url": "https://www.uniprot.org/uniprotkb/E1BJV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGPPLQGALRPGTRGRRARSAKSYVDSALELPAMPGDSVPARYTTPEATRAGARSSVSSTSVAPLVTDPLKSFVLFLENFAPLVNSLNLGIANPLLLGPSPLHFAQIKTQLALQQLNAIASHSSTPPYTLLNQAFLKIAMSRPRFNPRGNFPLQRPRAPNPSEMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFACHESYQNMEPQRMNVQVTQHQTDPRLTKEKLDFHEAQQKKEKPHGSRWDDEPHISASVGVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSRSRNKETLGNEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEDEFRSQPSISASVPAPNVMCNSMFPVEDVFRQMDFPSESSSNQSFFPVESGSKMSGLHISRGQSVLEPVKSVSQSISQTVNQTMSQSLIPPPMNQQPFSSELISTVSQQERIPREPVINSSNVHGSGGSKKNYQSEADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRHSRRSSSSHRFRRSRSPVRCMYRPRSRSPRICHRFIPRYRSRSRSPYRMRNPFRGSPKCFRSVSPERTSRRSERSSDRKKALEDVIQRFGHESEFSKQKHPEAVDKGHSPAQKLKTGSGAKTSVKSTSSAKSDSNIGGHCTRYKSKNLEDDTPSESKQMADKTVSLQRKLRKDQSSHYGPVLLISELPEDGCTEEEIRKIFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAVMEYIETTPLLIKGKSVKVCVPGKKKSQNKEMKKKMSDSKKTSASTLKKDTDASTAVETVTAASATKTGQTKTSATKVNKSSGKSAGSVKSVVTVAAKGNKASIKTAKSSGKKSLEVKKAGIVKNKDISKSVNVPESSEMKTNVEVKTTENGAKETISAALEATENEPVNKETEEMCMVLISDLPSKGYSVEEVSNLVKPFGGLKDILILSSHKKAFIEINRKSADSMIKFYTCFPISMDGNQLSISMAPENMNLKDEEAIFTTLIRENDPEVNIDKIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVYMSNKNKAILQLDSPESAQSMYSFLKQNPQNIGDHVLTCTLSPKMDSSEVKAEKDPELGKESPDLKNSPVDESEVQTTADSPSIKPSEVEEESVPSVQTGTFIQQKEPFEEEPEKTLCVSDFALETVEVETQGEEVKVEIPLVASTSASIDLFTENVGESVLNQQVYTGDFEKEETEIINPETELSTSDNTFIEERNIKGILEDSPSEADFFSGITESMIEAVAEVDKQETVSEIVPSTCVVALVPGISTGDEQAVSTKGISEKTNMDEKEENELNTKEARMDLKTGREKAEKNDRMVTEKLDKVVAAVKEKPAENSVTKACPNKTVVQANKPDETSKISMLVASNASSSKSGIKADVVSSTKARATASKSENQKSFLKSVLRDQINAEKRLSAKESGLLKPTSARSGVAENSSKLKPIQSGVTRGSSGRISALQGKDSKLDYRDVTKQPQETEAKPSIMKRDDSNNKTLTGQNTKNPKNTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPFHVKQNPLKGKRKEALKNTPSSELNLKKKKGKISAPRVVEGELSFVTLDEIGEEEDAAAQLAQALVTVDEVIDEDDINVEDMVKNSNSLLTLDELIDQDDCISHSETKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADISFGALNTKGDEGNTGRDSLGFISSQMPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKIELTQRKNDHPTDKRGDRKKRTVDKKKTKLEALSQVGPVNENVMEENPKTMIERRSAATVPTKRVRIGKMPPSEKVVTVEPVKDEEAFQISEESGLEDSEPEQKRKKIEDSSGRSVAPDVPEDLDFLVPKAGFFCPICSLFYSDEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR", "length": 2108, "header": "tr|A0AAA9TB71-1|A0AAA9TB71_BOVIN Isoform 1 of Zinc finger protein 638 OS=Bos taurus OX=9913 GN=ZNF638 PE=4 SV=1 CANONICAL=A0AAA9TB71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SN30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71/entry#A0AAA9SN30-1", "sequence": { "sequence": "MSRPRFNPRGNFPLQRPRAPNPSEMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFACHESYQNMEPQRMNVQVTQHQTDPRLTKEKLDFHEAQQKKEKPHGSRWDDEPHISASVGVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSRSRNKETLGNEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEDEFRSQPSISASVPAPNVMCNSMFPVEDVFRQMDFPSESSSNQSFFPVESGSKMSGLHISRGQSVLEPVKSVSQSISQTVNQTMSQSLIPPPMNQQPFSSELISTVSQQERIPREPVINSSNVHGSGGSKKNYQSEADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRHSRRSSSSHRFRRSRSPVRCMYRPRSRSPRICHRFIPRYRSRSRSPYRMRNPFRGSPKCFRSVSPERTSRRSERSSDRKKALEDVIQRFGHESEFSKQKHPEAVDKGHSPAQKLKTGSGAKTSVKSTSSAKSDSNIGGHCTRYKSKNLEDDTPSESKQMADKTVSLQRKLRKDQSSHYGPVLLISELPEDGCTEEEIRKIFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAVMEYIETTPLLIKGKSVKVCVPGKKKSQNKEMKKKMSDSKKTSASTLKKDTDASTAVETVTAASATKTGQTKTSATKVNKSSGKSAGSVKSVVTVAAKGNKASIKTAKSSGKKSLEVKKAGIVKNKDISKSVNVPESSEMKTNVEVKTTENGAKETISAALEATENEPVNKETEEMCMVLISDLPSKGYSVEEVSNLVKPFGGLKDILILSSHKKAFIEINRKSADSMIKFYTCFPISMDGNQLSISMAPENMNLKDEEAIFTTLIRENDPEVNIDKIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVYMSNKNKAILQLDSPESAQSMYSFLKQNPQNIGDHVLTCTLSPKMDSSEVKAEKDPELGKESPDLKNSPVDESEVQTTADSPSIKPSEVEEESVPSVQTGTFIQQKEPFEEEPEKTLCVSDFALETVEVETQGEEVKVEIPLVASTSASIDLFTENVGESVLNQQVYTGDFEKEETEIINPETELSTSDNTFIEERNIKGILEDSPSEADFFSGITESMIEAVAEVDKQETVSEIVPSTCVVALVPGISTGDEQAVSTKGISEKTNMDEKEENELNTKEARMDLKTGREKAEKNDRMVTEKLDKVVAAVKEKPAENSVTKACPNKTVVQANKPDETSKISMLVASNASSSKSGIKADVVSSTKARATASKSENQKSFLKSVLRDQINAEKRLSAKESGLLKPTSARSGVAENSSKLKPIQSGVTRGSSGRISALQGKDSKLDYRDVTKQPQETEAKPSIMKRDDSNNKTLTGQNTKNPKNTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPFHVKQNPLKGKRKEALKNTPSSELNLKKKKGKISAPRVVEGELSFVTLDEIGEEEDAAAQLAQALVTVDEVIDEDDINVEDMVKNSNSLLTLDELIDQDDCISHSETKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADISFGALNTKGDEGNTGRDSLGFISSQMPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKIELTQRKNDHPTDKRGDRKKRTVDKKKTKLEALSQVGPVNENVMEENPKTMIERRSAATVPTKRVRIGKMPPSEKVVTVEPVKDEEAFQISEESGLEDSEPEQKRKKIEDSSGRSVAPDVPEDLDFLVPKAGFFCPICSLFYSDEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSRIIW", "length": 1971, "header": "tr|A0AAA9SN30-1|A0AAA9TB71_BOVIN Computationally mapped isoform of Zinc finger protein 638 OS=Bos taurus OX=9913 GN=ZNF638 PE=4 SV=1 CANONICAL=A0AAA9TB71-1" }, "locus": { "chromosome": "11", "start_pos": 13233938, "end_pos": 13150545, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085382.1" } ] } }, { "isoform_ac": "A0AAA9TB71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71/entry#A0AAA9TB71-1", "sequence": { "sequence": "MGGPPLQGALRPGTRGRRARSAKSYVDSALELPAMPGDSVPARYTTPEATRAGARSSVSSTSVAPLVTDPLKSFVLFLENFAPLVNSLNLGIANPLLLGPSPLHFAQIKTQLALQQLNAIASHSSTPPYTLLNQAFLKIAMSRPRFNPRGNFPLQRPRAPNPSEMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFACHESYQNMEPQRMNVQVTQHQTDPRLTKEKLDFHEAQQKKEKPHGSRWDDEPHISASVGVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSRSRNKETLGNEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEDEFRSQPSISASVPAPNVMCNSMFPVEDVFRQMDFPSESSSNQSFFPVESGSKMSGLHISRGQSVLEPVKSVSQSISQTVNQTMSQSLIPPPMNQQPFSSELISTVSQQERIPREPVINSSNVHGSGGSKKNYQSEADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRHSRRSSSSHRFRRSRSPVRCMYRPRSRSPRICHRFIPRYRSRSRSPYRMRNPFRGSPKCFRSVSPERTSRRSERSSDRKKALEDVIQRFGHESEFSKQKHPEAVDKGHSPAQKLKTGSGAKTSVKSTSSAKSDSNIGGHCTRYKSKNLEDDTPSESKQMADKTVSLQRKLRKDQSSHYGPVLLISELPEDGCTEEEIRKIFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAVMEYIETTPLLIKGKSVKVCVPGKKKSQNKEMKKKMSDSKKTSASTLKKDTDASTAVETVTAASATKTGQTKTSATKVNKSSGKSAGSVKSVVTVAAKGNKASIKTAKSSGKKSLEVKKAGIVKNKDISKSVNVPESSEMKTNVEVKTTENGAKETISAALEATENEPVNKETEEMCMVLISDLPSKGYSVEEVSNLVKPFGGLKDILILSSHKKAFIEINRKSADSMIKFYTCFPISMDGNQLSISMAPENMNLKDEEAIFTTLIRENDPEVNIDKIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVYMSNKNKAILQLDSPESAQSMYSFLKQNPQNIGDHVLTCTLSPKMDSSEVKAEKDPELGKESPDLKNSPVDESEVQTTADSPSIKPSEVEEESVPSVQTGTFIQQKEPFEEEPEKTLCVSDFALETVEVETQGEEVKVEIPLVASTSASIDLFTENVGESVLNQQVYTGDFEKEETEIINPETELSTSDNTFIEERNIKGILEDSPSEADFFSGITESMIEAVAEVDKQETVSEIVPSTCVVALVPGISTGDEQAVSTKGISEKTNMDEKEENELNTKEARMDLKTGREKAEKNDRMVTEKLDKVVAAVKEKPAENSVTKACPNKTVVQANKPDETSKISMLVASNASSSKSGIKADVVSSTKARATASKSENQKSFLKSVLRDQINAEKRLSAKESGLLKPTSARSGVAENSSKLKPIQSGVTRGSSGRISALQGKDSKLDYRDVTKQPQETEAKPSIMKRDDSNNKTLTGQNTKNPKNTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPFHVKQNPLKGKRKEALKNTPSSELNLKKKKGKISAPRVVEGELSFVTLDEIGEEEDAAAQLAQALVTVDEVIDEDDINVEDMVKNSNSLLTLDELIDQDDCISHSETKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADISFGALNTKGDEGNTGRDSLGFISSQMPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKIELTQRKNDHPTDKRGDRKKRTVDKKKTKLEALSQVGPVNENVMEENPKTMIERRSAATVPTKRVRIGKMPPSEKVVTVEPVKDEEAFQISEESGLEDSEPEQKRKKIEDSSGRSVAPDVPEDLDFLVPKAGFFCPICSLFYSDEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR", "length": 2108, "header": "tr|A0AAA9TB71-1|A0AAA9TB71_BOVIN Isoform 1 of Zinc finger protein 638 OS=Bos taurus OX=9913 GN=ZNF638 PE=4 SV=1 CANONICAL=A0AAA9TB71-1" }, "locus": { "chromosome": "11", "start_pos": 13299952, "end_pos": 13156343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098376.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098376.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095954.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095954.1" } ] } }, { "isoform_ac": "E1BJV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71/entry#E1BJV5-1", "sequence": { "sequence": "MSRPRFNPRGNFPLQRPRAPNPSEMRPPGPFMRPGSMGLPRFYPAGRARGIPHRFACHESYQNMEPQRMNVQVTQHQTDPRLTKEKLDFHEAQQKKEKPHGSRWDDEPHISASVGVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRYPDEQLTPENMPLILRDIRMRKMGRRLPNLPSRSRNKETLGNEAVSSNVIDYGHASKYGYTEDPLEVRIYDPEIPTDEVEDEFRSQPSISASVPAPNVMCNSMFPVEDVFRQMDFPSESSSNQSFFPVESGSKMSGLHISRGQSVLEPVKSVSQSISQTVNQTMSQSLIPPPMNQQPFSSELISTVSQQERIPREPVINSSNVHGSGGSKKNYQSEADIPIRSPFGIVKASWLPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTHIESCRQLRQQNEGNRKENETPRRRSHSPSPRHSRRSSSSHRFRRSRSPVRCMYRPRSRSPRICHRFIPRYRSRSRSPYRMRNPFRGSPKCFRSVSPERTSRRSERSSDRKKALEDVIQRFGHESEFSKQKHPEAVDKGHSPAQKLKTGSGAKTSVKSTSSAKSDSNIGGHCTRYKSKNLEDDTPSESKQMADKTVSLQRKLRKDQSSHYGPVLLISELPEDGCTEEEIRKIFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAVMEYIETTPLLIKGKSVKVCVPGKKKSQNKEMKKKMSDSKKTSASTLKKDTDASTAVETVTAASATKTGQTKTSATKVNKSSGKSAGSVKSVVTVAAKGNKASIKTAKSSGKKSLEVKKAGIVKNKDISKSVNVPESSEMKTNVEVKTTENGAKETISAALEATENEPVNKETEEMCMVLISDLPSKGYSVEEVSNLVKPFGGLKDILILSSHKKAFIEINRKSADSMIKFYTCFPISMDGNQLSISMAPENMNLKDEEAIFTTLIRENDPEVNIDKIYDRFVHLDNLPEDGLQCVLCVGLQFGKVDHHVYMSNKNKAILQLDSPESAQSMYSFLKQNPQNIGDHVLTCTLSPKMDSSEVKAEKDPELGKESPDLKNSPVDESEVQTTADSPSIKPSEVEEESVPSVQTGTFIQQKEPFEEEPEKTLCVSDFALETVEVETQGEEVKVEIPLVASTSASIDLFTENVGESVLNQQVYTGDFEKEETEIINPETELSTSDNTFIEERNIKGILEDSPSEADFFSGITESMIEAVAEVDKQETVSEIVPSTCVVALVPGISTGDEQAVSTKGISEKTNMDEKEENELNTKEARMDLKTGREKAEKNDRMVTEKLDKVVAAVKEKPAENSVTKACPNKTVVQANKPDETSKISMLVASNASSSKSGIKADVVSSTKARATASKSENQKSFLKSVLRDQINAEKRLSAKESGLLKPTSARSGVAENSSKLKPIQSGVTRGSSGRISALQGKDSKLDYRDVTKQPQETEAKPSIMKRDDSNNKTLTGQNTKNPKNTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVNPFHVKQNPLKGKRKEALKNTPSSELNLKKKKGKISAPRVVEGELSFVTLDEIGEEEDAAAQLAQALVTVDEVIDEDDINVEDMVKNSNSLLTLDELIDQDDCISHSETKDVTVLSVAEEQDLLKQERLVTVDEIGEVEELPLNESADISFGALNTKGDEGNTGRDSLGFISSQMPEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEEDGDNDLKIELTQRKNDHPTDKRGDRKKRTVDKKKTKLEALSQVGPVNENVMEENPKTMIERRSAATVPTKRVRIGKMPPSEKVVTVEPVKDEEAFQISEESGLEDSEPEQKRKKIEDSSGRSVAPDVPEDLDFLVPKAGFFCPICSLFYSDEKAMTNHCKSTRHKQNTEKFMAKQRKEKEQNEAEERSSR", "length": 1955, "header": "tr|E1BJV5-1|A0AAA9TB71_BOVIN Computationally mapped isoform of Zinc finger protein 638 OS=Bos taurus OX=9913 GN=ZNF638 PE=4 SV=4 CANONICAL=A0AAA9TB71-1" }, "locus": { "chromosome": "11", "start_pos": 13233938, "end_pos": 13156343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012184.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012184.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012184.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012184.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of RNA splicing", "id": "GO:0043484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043484", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB71", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1498, "end_pos": 1500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1520, "end_pos": 1522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1586, "end_pos": 1588, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1641, "end_pos": 1643, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1654, "end_pos": 1656, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1829, "end_pos": 1831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 943, "end_pos": 945, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" }, { "id": "PS50171", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Matrin-type", "eco_id": "ECO_0000259", "start_pos": 2058, "end_pos": 2088, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB71" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 813, "end_pos": 883, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1498, "end_pos": 1500 }, { "start_pos": 1520, "end_pos": 1522 }, { "start_pos": 1586, "end_pos": 1588 }, { "start_pos": 1641, "end_pos": 1643 }, { "start_pos": 1654, "end_pos": 1656 }, { "start_pos": 1829, "end_pos": 1831 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 585, "end_pos": 587 }, { "start_pos": 620, "end_pos": 622 }, { "start_pos": 943, "end_pos": 945 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TB88-1", "uniprot_ac": "A0AAA9TB88", "uniprot_id": "A0AAA9TB88_BOVIN", "mass": { "chemical_mass": 60578.0, "monoisotopic_mass": 60578.0 }, "refseq": {}, "gene_names": [ { "name": "OIT3", "type": "recommended", "evidence": [ { "id": "A0AAA9TB88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88" } ] } ], "protein_names": [ { "name": "Oncoprotein-induced transcript 3 protein", "type": "recommended", "evidence": [ { "id": "A0AAA9TB88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in hepatocellular function and development.", "evidence": [ { "database": "UniProtKB", "id": "F1MH22", "url": "https://www.uniprot.org/uniprotkb/F1MH22#function" }, { "database": "UniProtKB", "id": "ARBA00056508", "url": "https://www.uniprot.org/uniprotkb/ARBA00056508#function" }, { "database": "UniProtKB", "id": "A0AAA9TB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OIT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88", "locus": { "chromosome": "28", "start_pos": 28942806, "end_pos": 28915275, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009348", "url": "https://www.ensembl.org/id/ENSBTAG00000009348" } ] } } ], "crossref": [ { "id": "A0AAA9TB88", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TB88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057774", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057774", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EFPRHYT", "url": "https://omabrowser.org/oma/group/EFPRHYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH22", "url": "https://www.orthodb.org/?gene=F1MH22", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36191", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36191", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36191:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36191:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23283", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23283", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SQ82", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ82-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH22", "url": "https://www.uniprot.org/uniprotkb/F1MH22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH22-1", "url": "https://www.uniprot.org/uniprotkb/F1MH22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYRCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGPISIDWED", "length": 547, "header": "tr|A0AAA9TB88-1|A0AAA9TB88_BOVIN Isoform 1 of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=4 SV=1 CANONICAL=A0AAA9TB88-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SQ82-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88/entry#A0AAA9SQ82-1", "sequence": { "sequence": "MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYRCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDLCFR", "length": 321, "header": "tr|A0AAA9SQ82-1|A0AAA9TB88_BOVIN Computationally mapped isoform of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=4 SV=1 CANONICAL=A0AAA9TB88-1" }, "locus": { "chromosome": "28", "start_pos": 28940468, "end_pos": 28915334, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098120.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098120.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086098.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086098.1" } ] } }, { "isoform_ac": "A0AAA9TB88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88/entry#A0AAA9TB88-1", "sequence": { "sequence": "MPQLLLLACLLIIVTRVAPRALDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYRCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGPISIDWED", "length": 547, "header": "tr|A0AAA9TB88-1|A0AAA9TB88_BOVIN Isoform 1 of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=4 SV=1 CANONICAL=A0AAA9TB88-1" }, "locus": { "chromosome": "28", "start_pos": 28942183, "end_pos": 28915334, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108021.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108021.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095975.1" } ] } }, { "isoform_ac": "F1MH22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88/entry#F1MH22-1", "sequence": { "sequence": "SKLRLLLLLLLLLLSRFSPLDPCSAYISLNEPWRNTEHQFDESRGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKSCPGGYYVYRLTKPSVCFHVYCGHFYDICDDDCHGSCLGTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGIGRVLRSDGKTCEDIEGCHNNNGGCSHSCLTSETGYRCECPRGLVLSEDNHTCQVPVFCKSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDHEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEIMKYYIIQDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDERSRCAQGCHRRVRREASTEGEDASGPRSQMLTGGPISIDWED", "length": 545, "header": "tr|F1MH22-1|A0AAA9TB88_BOVIN Computationally mapped isoform of Oncoprotein-induced transcript 3 protein OS=Bos taurus OX=9913 GN=OIT3 PE=4 SV=4 CANONICAL=A0AAA9TB88-1" }, "locus": { "chromosome": "28", "start_pos": 28942183, "end_pos": 28919403, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012305.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012305.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012305.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012305.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QN47-1", "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "Oit3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPLSLLLTCLFTTIIPVSPIALDPCSAYISLNEPWRNTDHQFDESQSQPLCDNHMNGEWYRFTGMAGDAMPTFCVPENHCGTHAPVWLNGSHPLESDGIVQRQACASFKGNCCLWNTTVEVKACPGGYYVYRLAKPSVCFHVYCGHFYDICDEDCHGSCADTPECTCSPGTSIGPDGQTCFDENECEQNNGGCSEICVNLKNSHRCVCGVGRVLRSDGKTCEDIEGCHNNNGGCSHSCVGSERGYQCECPRGLVLSDDNHTCQVPVLCKSSAIEVSVPRELVGGLELFLTNNSCRGVSNGTHVNIVFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSELLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLEIFKDHEFEEPYRENLPTLKLRDSLYFGIEPLVHVSGLESLVESCFATPTAKMDEILKYYLIQDGCVSDDSVKQYSSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRVRREVGDDEDSAGLQDQTLTGGPITIDWED", "length": 546 }, "evidence": [ { "id": "A0AAA9TB88", "url": "https://omabrowser.org/oma/group/A0AAA9TB88/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SU75-1", "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "OIT3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQFLLLTCLFITITLVSPKALDPCSAYISLNEPWRNTDHQFDESQGSPLCDNSVDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPREGDGIVQRQACASFNGNCCLWNTTVEVKACPGGYYVYRLTKPSVCFHVYCGHFYDICDEDCHGSCLDTSECTCSPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGRTCEDIEGCHNNNGGCSHSCLTSEKGYQCECPRGLVLSEDNHTCQVPVFCRSNTIEVSIPRDLVGGLELFLTNTSCRGVSNGTHVNIIFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNTPLEIMSRSHGIFPFTLEIFKDNEFEEPYREALPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTSKIDEILKYYLIRDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGMLDQRSRCAQGCHRRMRREAVEGEDAAGLQSQMLTGGPISIDWED", "length": 546 }, "evidence": [ { "id": "A0AAA9TB88", "url": "https://omabrowser.org/oma/group/A0AAA9TB88/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6V0K7-1", "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "Oit3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLSLLLACLFTTVTLQSPVVLDPCSAYISLNEPWRNTDHQFDESQSQPLCDNHMDGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFKGNCCLWNTTVEVKACPGGYYVYRLAKPSVCFHIYCGHFYDICDEDCHGSCLDTTECACSPGTSLGPDGQTCFDENECEHNNGGCSEICVNLKNSHRCACGVGRVLRSDGKTCEDIEGCHSNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVPVLCKSSAIEVSVPRELVGGLELFLTNTSCRGVSNGTHVNIIFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLEIFKDHEFEEPYRETLPTLKLRDSLYFGIEPLVHVSGLESLVESCFATPTAKVDEILKYYLIRDGCVSDDSVKQYSSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRVRREAGEDEDSAGLQSQTLTGGPISIDWEE", "length": 546 }, "evidence": [ { "id": "A0AAA9TB88", "url": "https://omabrowser.org/oma/group/A0AAA9TB88/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R4V5-1", "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "Oit3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLSLLLTCLSTTVTLVSPAVLDPCSAYISLNEPWRNTDHQFDESQNQPLCDNHMNGEWYRFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEEDGIVQRQACASFKGNCCLWNATVEVKACPRGYYVYRLARPSVCFHVYCGHFYDICDEDCHGNCLDTTECACSPGTSLGPDGQTCFDENECEHNNGGCSEICVNLKNSHRCACGVGRVLRSDGKTCEDIEGCHNNNGGCSHSCLGSEEGYQCECPRGLVLSEDNHTCQVPVLCKSSAIEVSVPRELVGGLELFLTNTSCRGVSNGTHVNIVFSLKTCGTVVDVVNDKIVASNIVTGLPKETPGSSGDIIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNAPLEIRSRNHGIFPFTLEIFKDHEFEEPYRETLPTLKLRDSLYFGIEPLVHVNGLESLVESCFATPTAKMDEILKYYLIQDGCVSDDSVKQYSSRDHLAKHFQAPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRVRREVGEDEDSAGLQSQTLTGGPIAIDWED", "length": 546 }, "evidence": [ { "id": "A0AAA9TB88", "url": "https://omabrowser.org/oma/group/A0AAA9TB88/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WWZ8-1", "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "OIT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPFLLLTCLFITGTSVSPVALDPCSAYISLNEPWRNTDHQLDESQGPPLCDNHVNGEWYHFTGMAGDAMPTFCIPENHCGTHAPVWLNGSHPLEGDGIVQRQACASFNGNCCLWNTTVEVKACPGGYYVYRLTKPSVCFHVYCGHFYDICDEDCHGSCSDTSECTCAPGTVLGPDRQTCFDENECEQNNGGCSEICVNLKNSYRCECGVGRVLRSDGKTCEDVEGCHNNNGGCSHSCLGSEKGYQCECPRGLVLSEDNHTCQVPVLCKSNAIEVNIPRELVGGLELFLTNTSCRGVSNGTHVNILFSLKTCGTVVDVVNDKIVASNLVTGLPKQTPGSSGDFIIRTSKLLIPVTCEFPRLYTISEGYVPNLRNSPLEIMSRNHGIFPFTLEIFKDNEFEEPYREALPTLKLRDSLYFGIEPVVHVSGLESLVESCFATPTSKIDEVLKYYLIRDGCVSDDSVKQYTSRDHLAKHFQVPVFKFVGKDHKEVFLHCRVLVCGVLDERSRCAQGCHRRMRRGAGGEDSAGLQGQTLTGGPIRIDWED", "length": 545 }, "evidence": [ { "id": "A0AAA9TB88", "url": "https://omabrowser.org/oma/group/A0AAA9TB88/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TB88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB88" }, { "id": "PS51034", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51034" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZP", "eco_id": "ECO_0000259", "start_pos": 267, "end_pos": 516, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 259, "end_pos": 261 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 299, "end_pos": 301 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], 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] }, { "id": "IPR025768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529294", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529294", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PPKEEIY", "url": "https://omabrowser.org/oma/group/PPKEEIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEY9", "url": "https://www.orthodb.org/?gene=E1BEY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13586", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13586", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13586:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13586:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856907", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856907", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEY9", "url": "https://www.uniprot.org/uniprotkb/E1BEY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEY9-1", "url": "https://www.uniprot.org/uniprotkb/E1BEY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSGSASSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLGASFPSVSVSKSPMVEQAVQTGSLDNLNSKKLLPGKGTVGMQLNGRPAPPGTKATTDIAQPAAVQTQGQVNDENRRPQRRRSGNRRTRNRSRGQSRPTNIKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSDEAPADEDHLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSFRGGFRGGRGNGATRRNPTSHRAGTGRV", "length": 385, "header": "tr|A0AAA9TAP4-1|A0AAA9TAP4_BOVIN Isoform 1 of LSM family member 14B OS=Bos taurus OX=9913 GN=LSM14B PE=3 SV=1 CANONICAL=A0AAA9TAP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4/entry#A0AAA9SSV5-1", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSGSASSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDMSSEPHQLTSKGASFPSVSVSKSPMVEQAVQTGSLDNLNSKKLLPGKGTVGMQLNGRPAPPGTKATTGNRRTRNRSRGQSRPTNIKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSDEAPADEDHLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSFRGGFRGGRGNGATRRNPTSHRAGTGRV", "length": 398, "header": "tr|A0AAA9SSV5-1|A0AAA9TAP4_BOVIN Computationally mapped isoform of LSM family member 14B OS=Bos taurus OX=9913 GN=LSM14B PE=3 SV=1 CANONICAL=A0AAA9TAP4-1" }, "locus": { "chromosome": "13", "start_pos": 55072069, "end_pos": 55063273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104146.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104146.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088428.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088428.1" } ] } }, { "isoform_ac": "A0AAA9SZ46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4/entry#A0AAA9SZ46-1", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSGSASSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDMSSEPHQLTSKGNSSFGELHAVLRLRARGKPVARMTVAVANNLLSPWISS", "length": 220, "header": "tr|A0AAA9SZ46-1|A0AAA9TAP4_BOVIN Computationally mapped isoform of LSM family member 14B OS=Bos taurus OX=9913 GN=LSM14B PE=3 SV=1 CANONICAL=A0AAA9TAP4-1" }, "locus": { "chromosome": "13", "start_pos": 55072069, "end_pos": 55067575, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123086.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123086.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088648.1" } ] } }, { "isoform_ac": "A0AAA9TAP4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4/entry#A0AAA9TAP4-1", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSGSASSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLGASFPSVSVSKSPMVEQAVQTGSLDNLNSKKLLPGKGTVGMQLNGRPAPPGTKATTDIAQPAAVQTQGQVNDENRRPQRRRSGNRRTRNRSRGQSRPTNIKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSDEAPADEDHLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSFRGGFRGGRGNGATRRNPTSHRAGTGRV", "length": 385, "header": "tr|A0AAA9TAP4-1|A0AAA9TAP4_BOVIN Isoform 1 of LSM family member 14B OS=Bos taurus OX=9913 GN=LSM14B PE=3 SV=1 CANONICAL=A0AAA9TAP4-1" }, "locus": { "chromosome": "13", "start_pos": 55072069, "end_pos": 55063273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094645.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094645.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093080.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093080.1" } ] } }, { "isoform_ac": "E1BEY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4/entry#E1BEY9-1", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSGSASSFQPHVPYSPFRGMPPYSQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDMSSEPHQLTSKGASFPSVSVSKSPMVEQAVQTGSLDNLNSKKLLPGKGTVGMQLNGRPAPPGTKATTDIAQPAAVQTQGQVNDENRRPQRRRSGNRRTRNRSRGQSRPTNIKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSDEAPADEDHLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSFRGGFRGGRGNGATRRNPTSHRAGTGRV", "length": 424, "header": "tr|E1BEY9-1|A0AAA9TAP4_BOVIN Computationally mapped isoform of LSM family member 14B OS=Bos taurus OX=9913 GN=LSM14B PE=3 SV=3 CANONICAL=A0AAA9TAP4-1" }, "locus": { "chromosome": "13", "start_pos": 55072069, "end_pos": 55063273, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028723.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028723.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028723.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028723.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529294", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529294", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZY0-1", "protein_name": "LSM family member 14B", "gene_name": "Lsm14b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGYERTGAARGGGRPRMWLRRRSSPAPLRLRLSASFRSLSRSLVARRPLGAAEGASAAAARSCAGVGGQATARRRSGRGPALVPRALRAPAAAMSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHALPQDPAIVQSSLGSASASPFQPHVPYSPFRGMPPYGQLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDMSSEPPQLTCKGAGFPSTPVGKSPMVEQAVQTSSVDNLNAKKLLPSKVTSATQLNGRQAQPSSKPASDVVQPAPVHAQGQVNDENRRPPRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGDEKDPAVMAQSEETPPEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV", "length": 517 }, "evidence": [ { "id": "A0AAA9TAP4", "url": "https://omabrowser.org/oma/group/A0AAA9TAP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q898-1", "protein_name": "Protein LSM14 homolog B", "gene_name": "lsm14b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSGTPYIGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEGRPTDRPVPARDEIFEYIIFRGSDIKDITVCEPLKVHHGLPQDPAIVQSSVGTSSVHYPSQSSYSPYRGVLPAYNQLAASSLFSQQYAAALGLGLHGVSGRRGPMVEQAVQTVPAEKTQQQQQQKKSLGGGQQGGAQRGARAQRGDSSSAQQAVLKGQSPANNENKPPTSRRKPGTRRSRNRGQGQLLVGSTKPSTLQFEADFDFETANAQFNKDDLEKEIEDQNSVQEPRSPPEEHSAVEQQKQDSEHESAAEDDPLGPKCFYNKAKSFFDNISSELRSRRTTWAEERKLNVETFGVPGRYLRAGGFRGFGGRRGRGAAQRTLTHRAGSARV", "length": 380 }, "evidence": [ { "id": "A0AAA9TAP4", "url": "https://omabrowser.org/oma/group/A0AAA9TAP4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P45978-1", "protein_name": "Protein SCD6", "gene_name": "SCD6", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQYIGKTISLISVTDNRYVGLLEDIDSEKGTVTLKEVRCFGTEGRKNWGPEEIYPNPTVYNSVKFNGSEVKDLSILDANINDIQPVVPQMMPPASQFPPQQAQSPPQAQAQAHVQTNPQVPKPESNVPAAVAGYGVYTPTSTETATASMNDKSTPQDTNVNSQSRERGKNGENEPKYQRNKNRSSNRPPQSNRNFKVDIPNEDFDFQSNNAKFTKGDSTDVEKEKELESAVHKQDESDEQFYNKKSSFFDTISTSTETNTNMRWQEEKMLNVDTFGQASARPRFHSRGLGRGRGNYRGNRGNRGRGGQRGNYQNRNNYQNDSGAYQNQNDSYSRPANQFSQPPSNVEF", "length": 349 }, "evidence": [ { "id": "A0AAA9TAP4", "url": "https://omabrowser.org/oma/group/A0AAA9TAP4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8CGC4-1", "protein_name": "Protein LSM14 homolog B", "gene_name": "Lsm14b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMPPYGQLAASSLLSQQYAASLGLGAGFPSTPVGKSPMVEQAVQTSSVDNLNAKKLLPSKVTSATQLNGRQAQPSSKPASDVVQPAPVHTQGQVNDENRRPPRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKADKGEEKDPAVMAQSEETAAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV", "length": 385 }, "evidence": [ { "id": "A0AAA9TAP4", "url": "https://omabrowser.org/oma/group/A0AAA9TAP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BX40-1", "protein_name": "Protein LSM14 homolog B", "gene_name": "LSM14B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSSGTPYLGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV", "length": 385 }, "evidence": [ { "id": "A0AAA9TAP4", "url": "https://omabrowser.org/oma/group/A0AAA9TAP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "ovarian follicle development", "id": "GO:0001541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001541", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "membraneless organelle assembly", "id": "GO:0140694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "meiotic cell cycle process involved in oocyte maturation", "id": "GO:1903537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "maternal mRNA clearance", "id": "GO:0141065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 35, "end_pos": 37, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PS51512", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51512" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DFDF", "eco_id": "ECO_0000259", "start_pos": 241, "end_pos": 277, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PRU00846", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00846" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "FFD box", "eco_id": "ECO_0000256", "start_pos": 310, "end_pos": 326, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PS51513", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51513" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FFD box profile", "eco_id": "ECO_0000259", "start_pos": 310, "end_pos": 326, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PS52002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS52002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sm", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 83, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PRU00869", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00869" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "TFG box", "eco_id": "ECO_0000256", "start_pos": 330, "end_pos": 350, "start_aa": "Ser", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAP4" }, { "id": "PS51536", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51536" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TFG box profile", "eco_id": "ECO_0000259", "start_pos": 330, "end_pos": 350, "start_aa": 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"reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SKOR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2", "locus": { "chromosome": "10", "start_pos": 14680751, "end_pos": 14666581, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068922", "url": "https://www.ensembl.org/id/ENSBTAG00000068922" } ] } } ], "crossref": [ { "id": "A0AAA9TCA2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd21080", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21080", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786611", "url": "https://www.ncbi.nlm.nih.gov/gene/786611", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003380", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003380", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009061", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLCGLGQVTRRLWAPLPPQPENGIGFLATQAFLRSGGMEALTTQLGPGREGNSSPNSKQELQPYSGSSALKPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWEDVKAMFNGGTRKRTFSLQGGGGGGANGGSGGQGKGGAGGGGGGPGCGADMAPGPPPHKSLRCGEEEAAGPPGPPPPHAQRGLGLAAGAGGPAGPGGPGGGAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYGFPTAFGLCPKKDDPVLGAGEPKGGPGPGSGGGAGTGAGAGGPGTGHLPPGAGTGPGGGAMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPPYPAAQSQAKAVAAAVAAAAAAAAAAAGGGGPEPLDGTEPTKEGGLVAEERCPSALSRGPLDEDGADEALPPPLAPLAPPPPPPARKGSYVSAFRPVVKDAESIAKLYGSAREAYGGGPARGPGPGAGTGGGYVSPDFLSEGSSSYHSASPDVDTADEPEVDVESNRFPDEEGAPDEAEPGAPSTGGSPNGDQTAGPPSITSSGADGPTDSPEGGSPRPRRRPGLPPASRAAFGDLAADDMVRRPEKSSPSGGYELREACGPLGGPAPAKVYAPERDEHVKSAAAALGPAASYLCAPEAHEPDKEDNHSTADDLETRKCYPDQRSISQTSPANTDRGEDGLTLDVTGTQLVEKDIENLARDELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHHFSCKMLTPRHCTGNCSFKPPLLP", "length": 962, "header": "tr|A0AAA9TCA2-1|A0AAA9TCA2_BOVIN Isoform 1 of SKI family transcriptional corepressor 1 OS=Bos taurus OX=9913 GN=SKOR1 PE=3 SV=1 CANONICAL=A0AAA9TCA2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2/entry#A0AAA9STJ9-1", "sequence": { "sequence": 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Computationally mapped isoform of SKI family transcriptional corepressor 1 OS=Bos taurus OX=9913 GN=SKOR1 PE=3 SV=1 CANONICAL=A0AAA9TCA2-1" }, "locus": { "chromosome": "10", "start_pos": 14679747, "end_pos": 14671877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115020.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115020.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086409.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086409.1" } ] } }, { "isoform_ac": "A0AAA9TCA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2/entry#A0AAA9TCA2-1", "sequence": { "sequence": "MALLCGLGQVTRRLWAPLPPQPENGIGFLATQAFLRSGGMEALTTQLGPGREGNSSPNSKQELQPYSGSSALKPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWEDVKAMFNGGTRKRTFSLQGGGGGGANGGSGGQGKGGAGGGGGGPGCGADMAPGPPPHKSLRCGEEEAAGPPGPPPPHAQRGLGLAAGAGGPAGPGGPGGGAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYGFPTAFGLCPKKDDPVLGAGEPKGGPGPGSGGGAGTGAGAGGPGTGHLPPGAGTGPGGGAMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPPYPAAQSQAKAVAAAVAAAAAAAAAAAGGGGPEPLDGTEPTKEGGLVAEERCPSALSRGPLDEDGADEALPPPLAPLAPPPPPPARKGSYVSAFRPVVKDAESIAKLYGSAREAYGGGPARGPGPGAGTGGGYVSPDFLSEGSSSYHSASPDVDTADEPEVDVESNRFPDEEGAPDEAEPGAPSTGGSPNGDQTAGPPSITSSGADGPTDSPEGGSPRPRRRPGLPPASRAAFGDLAADDMVRRPEKSSPSGGYELREACGPLGGPAPAKVYAPERDEHVKSAAAALGPAASYLCAPEAHEPDKEDNHSTADDLETRKCYPDQRSISQTSPANTDRGEDGLTLDVTGTQLVEKDIENLARDELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHHFSCKMLTPRHCTGNCSFKPPLLP", "length": 962, "header": "tr|A0AAA9TCA2-1|A0AAA9TCA2_BOVIN Isoform 1 of SKI family transcriptional corepressor 1 OS=Bos taurus OX=9913 GN=SKOR1 PE=3 SV=1 CANONICAL=A0AAA9TCA2-1" }, "locus": { "chromosome": "10", "start_pos": 14679747, "end_pos": 14671541, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124884.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124884.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095686.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095686.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 708, "start_aa": "Thr", "end_pos": 708, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr708", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:786611", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786611", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 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"start_pos": 54, "end_pos": 56 }, { "start_pos": 806, "end_pos": 808 }, { "start_pos": 953, "end_pos": 955 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAL9-1", "uniprot_ac": "A0AAA9TAL9", "uniprot_id": "A0AAA9TAL9_BOVIN", "mass": { "chemical_mass": 79559.0, "monoisotopic_mass": 79559.0 }, "refseq": { "ac": "XP_002698212", "name": "IQ domain-containing protein E isoform X8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698212" }, "gene_names": [ { "name": "IQCE", "type": "recommended", "evidence": [ { "id": "A0AAA9TAL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9" } ] }, { "name": "IQCE", "type": "synonym", "evidence": [ { "id": "XP_002698212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698212" } ] } ], "protein_names": [ { "name": "IQ domain-containing protein E isoform X8", "type": "synonym", "evidence": [ { "id": "XP_002698212", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698212" } ] }, { "name": "IQ motif containing E", "type": "synonym", "evidence": [ { "id": "A0AAA9TAL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IQCE", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9", "locus": { "chromosome": "25", "start_pos": 40711126, "end_pos": 40672502, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014503", "url": "https://www.ensembl.org/id/ENSBTAG00000014503" } ] } } ], "crossref": [ { "id": "A0AAA9TAL9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAL9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014503", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014503", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "618833", "url": "https://www.ncbi.nlm.nih.gov/gene/618833", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052318", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052318", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TLISKCQ", "url": "https://omabrowser.org/oma/group/TLISKCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N1D1", "url": "https://www.orthodb.org/?gene=F1N1D1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22590", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22590", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22590:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22590:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5635838", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5635838", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002698212", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698212", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1D1", "url": "https://www.uniprot.org/uniprotkb/F1N1D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1D1-1", "url": "https://www.uniprot.org/uniprotkb/F1N1D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQGTAEPASETGDDSLSAITFDSDSDTKAKKKSFHKPPPTSLKSPYHSKPRKVASWRSLRTAASMPLGGRMSLTPQKLCLGSSKQGSLTPALTSDLTLDCAWTHSPSSAPDFVTEALRMKRSNLRRSASHGYVPGNPVYREKEDMYDEIIELKKSLNMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDASRGPDFVRTLAEKRPDAGWVINGLKQRVLKLEQQCKEKDNIINKLQTDVKTTNLEEMRIAMETYYEEIHRLHGLLASSEMTGKRPPVEKKIGLKRQKKMSSALLSLSRSVQELTEENQSLKEDLDRMLSNSPTASKIKGYTDWSKPRLVRRIAELEKKLSSMESPKPQASEAARSTSLTPSASSPTLHLQENERLHGAVKSLKGERSALHTQLQERDLEVKQLLQTKAELEKELESMKEGERERREREKALREEVQTLTRKFQELEGSKKDKEDEPVAAAPQTHEEPSQPPSPTASPSQPDAEPDWNQGGSSWPPSTCSEGRRDEAARVLQRRWKGYQRQKERALLDEAATVLQAAFRGHLARARLLSRAACVSEPPRVPSPPTQDSPEPRIPSPAAQAEGDPWQEEAVTIIQSAFRAHLARARHSDPGPGASTAAVPDRPAQPPPRAPCSPPCPVAGPGQGDSEGSSRETAKGPAPEDGAPRPPPCSEPPVSVLQPMAPTPAEDVNSDDSDEIVLAPSLPTRKSACLP", "length": 720, "header": "tr|A0AAA9TAL9-1|A0AAA9TAL9_BOVIN Isoform 1 of IQ motif containing E OS=Bos taurus OX=9913 GN=IQCE PE=4 SV=2 CANONICAL=A0AAA9TAL9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9/entry#A0AAA9SUC1-1", "sequence": { "sequence": "MSQGTAEPASETGDDSLSAITFDSDSDTKAKKKSFHKPPPTSLKSPYHSKPRKVASWRSLRTAASMPLGGRMSLTPQKLCLGSSKQGSLTPALTSDLTLDCAWTHSPSSAPDFVTEALRMKRSNLRRSASHGYVPGNPVYREKEDMYDEIIELKKSLNMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDASRGPDFVRTLAEKRPDAGWVINGLKQRVLKLEQQCKEKDNIINKLQTDVKTTNLEEMRIAMETYYEEIHRLHGLLASSEMTGKRPPVEKKIGLKRQKKMSSALLSLSRSVQELTEENQSLKEDLDRMLSNSPTASKIKGYTDWSKPRLVRRIAELEKKLSSMESPKPQASEAARSTSLTPSASSPTLHLQENERLHGAVKSLKGERSALHTQLQERDLEVKQLLQTKAELEKELESMKEGERERREREKALREEVQTLTRKFQELEGSKKDKEDEPVAAAPQTHEEPSQPPSPTASPSQPDAEPDWNQGGSSWPPSTCSEGRRDEAARVLQRRWKGYQRQKERALLDEHPLSTLVRTSVLRPRAEGPRSTDRKAGQSRLEGSYRAAGGFPGASSSGEAVVQGSLCLRTPQGAEPSHPGLARAPHPEPCCPGRGRPVARGGRHHHPVCLPGTPGTGQAQVGPPAGPCVQTPPGGSRLPSREAQAEPPVSVLQPMAPTPAEDVNSDDSDEIVLAPSLPTRKSACLP", "length": 715, "header": "tr|A0AAA9SUC1-1|A0AAA9TAL9_BOVIN Computationally mapped isoform of IQ motif containing E OS=Bos taurus OX=9913 GN=IQCE PE=4 SV=1 CANONICAL=A0AAA9TAL9-1" }, "locus": { "chromosome": "25", "start_pos": 40710122, "end_pos": 40672716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087610.1" } ] } }, { "isoform_ac": "A0AAA9TAL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9/entry#A0AAA9TAL9-1", "sequence": { "sequence": "MSQGTAEPASETGDDSLSAITFDSDSDTKAKKKSFHKPPPTSLKSPYHSKPRKVASWRSLRTAASMPLGGRMSLTPQKLCLGSSKQGSLTPALTSDLTLDCAWTHSPSSAPDFVTEALRMKRSNLRRSASHGYVPGNPVYREKEDMYDEIIELKKSLNMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDASRGPDFVRTLAEKRPDAGWVINGLKQRVLKLEQQCKEKDNIINKLQTDVKTTNLEEMRIAMETYYEEIHRLHGLLASSEMTGKRPPVEKKIGLKRQKKMSSALLSLSRSVQELTEENQSLKEDLDRMLSNSPTASKIKGYTDWSKPRLVRRIAELEKKLSSMESPKPQASEAARSTSLTPSASSPTLHLQENERLHGAVKSLKGERSALHTQLQERDLEVKQLLQTKAELEKELESMKEGERERREREKALREEVQTLTRKFQELEGSKKDKEDEPVAAAPQTHEEPSQPPSPTASPSQPDAEPDWNQGGSSWPPSTCSEGRRDEAARVLQRRWKGYQRQKERALLDEAATVLQAAFRGHLARARLLSRAACVSEPPRVPSPPTQDSPEPRIPSPAAQAEGDPWQEEAVTIIQSAFRAHLARARHSDPGPGASTAAVPDRPAQPPPRAPCSPPCPVAGPGQGDSEGSSRETAKGPAPEDGAPRPPPCSEPPVSVLQPMAPTPAEDVNSDDSDEIVLAPSLPTRKSACLP", "length": 720, "header": "tr|A0AAA9TAL9-1|A0AAA9TAL9_BOVIN Isoform 1 of IQ motif containing E OS=Bos taurus OX=9913 GN=IQCE PE=4 SV=2 CANONICAL=A0AAA9TAL9-1" }, "locus": { "chromosome": "25", "start_pos": 40710122, "end_pos": 40672716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093059.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093059.2" } ] } }, { "isoform_ac": "F1N1D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL9/entry#F1N1D1-1", "sequence": { "sequence": "MSQGTAEPASETGDDSLSAITFDSDSDTKAKKKSFHKPPPTSLKSPYHSKPRKVASWRSLRTAASMPLGGRMSLTPQKLCLGSSKQGSLTPALTSDLTLDCAWTHSPSSAPDFVTEALRMKRSNLRRSASHGYVPGNPVYREKEDMYDEIIELKKSLNMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDASRGPDFVRTLAEKRPDAGWVINGLKQRVLKLEQQCKEKDNIINKLQTDVKTTNLEEMRIAMETYYEEIHRLHGLLASSEMTGKRPPVEKKIGLKRQKKMSSALLSLSRSVQELTEENQSLKEDLDRMLSNSPTASKIKGYTDWSKPRLVRRIAELEKKLSSMESPKPQASEAARSTSLTPSASSPTLHLQENERLHGAVKSLKGERSALHTQLQERDLEVKQLLQTKAELEKELESMKEGERERREREKALREEVQTLTRKFQELEGSKKDKEDEPVAAAPQTHEEPSQPPSPTASPSQPDAEPDWNQGGSSWPPSTCSEGRRDEAARVLQRRWKGYQRQKERALLDEAATVLQAAFRGHLARARLLSRAACVSEPPRVPSPPTQDSPEPRIPSPAAQAEGDPWQEEAVTIIQSAFRAHLARARHSDPGPGASTAAVPDRPAQPPPRAPCSPPCPVAGPGQGDSEGSSRETAKGPAPEDGAPRPPPCSDSSGGRSGGLVFPSLEEFSTVCCDPHSQRL", "length": 709, "header": "tr|F1N1D1-1|A0AAA9TAL9_BOVIN Computationally mapped isoform of IQ motif containing E OS=Bos taurus OX=9913 GN=IQCE PE=4 SV=4 CANONICAL=A0AAA9TAL9-1" }, "locus": { "chromosome": "25", "start_pos": 40708008, "end_pos": 40672716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019288.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019288.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019288.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019288.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 485, "start_aa": "Thr", "end_pos": 485, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr485", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 692, "start_aa": "Thr", "end_pos": 692, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr692", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5635838", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5635838", "resource": "Reactome", "description": "Activation of SMO" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M2F5-1", "protein_name": "IQ domain-containing protein E", "gene_name": "Iqce", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLYTSKKNPLRRNLVLRVVPYALSPESTQHGDPRNLCPLGYIVAATVCVNPTGAPEVGSESTAGSDIESQPCLREAIGSIRAPGETKNSHKRQGAIAQCNPGRVHGWPLARAHTARAQDSPGIGGRTTSGALWPRHGCHGTRLAGRPPKLRAELAGPPRPRSAAAMSLGTTDLTSETGDDSLSAISFDSDVESKTKRKPLHKPPSTSPKSPYYSKPKKVTSWRSLKTAGSMPLSSRMSLTPQKLWLGTSKQGHVSGTSVYREKEDMYDEIIELKKSLHMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPGRGPDFVRTLAEKKPDTGWVITGLKQRIFRLEQQCKEKDSTINKLQTDMKTTNLEEMRIAMETYYEEIHRLQTLLASSEATGKKPILEKKMGVKRQKKMSSALLNLTRSVQELTEENQSLKEDLDRMLSNSPTVSKIKGYVDWSKPRLLRRIAELEKKVSSSESPKNSASELVKPNPVVPSPSNISVQKQLKGDQSKEDQPKVDPSEDQEHLQGTVKTLREELSALQEQLLGKDLEMKQMLQSKIDLEKELETAREGEKESQEREQALREEVEALTKKCQELEEAKRQETQERQDSFIAMTHEAHPEVHAPSPCSRHSEPDSDNNADNNAGEDGGSQPPALCSEERREAAIRTLQAQWKAHRCKKRKAALDEAATVLQAAFRGHLARSKLVPNKAPDSRSPSLPGLPSPLNQSSPSPPVPSPISPAEDSLTQEESIIVIQSILRGYLAQARVIANCCQEKTGPSQREAVSVTPSESASPPSLEASPGKDSEESGGEVAEDEDEAEEPPDPQPYSGALSMGLHAEEELRETAASEPAPSVPDSARGGQGDCPSSSSLEAVPCGKDAMCEERSSSTGSARPSLAEPSPPGLQPLSPPPVEDICSDDSDDIIFSPFLPRKKSPSPF", "length": 935 }, "evidence": [ { "id": "A0AAA9TAL9", "url": "https://omabrowser.org/oma/group/A0AAA9TAL9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F5G1-1", "protein_name": "IQ domain-containing protein E isoform X1", "gene_name": "iqce", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVVAGELGTEEEVEDLAEDSLCSSYVSDTEKQPRKKKVSGRPPPSPKSPYLNSANLHMKRAPAASCRTMKGLQLQNCKTPPAAPHRDVWLHLQDDGHGSLSKSPKVMDCSVTQSSISSARTPEYLKEALGMKKPKYSRSASNGYVPGTPDYKDKEEMYDEIIDLKKTIQTQKAESDKLRAKLRRFEEENCKKDRQIEQLLDPAKDPEYARSLVDRKTDPRSIINGLKQRILRLEQQCKEKENALSQLQSDHKTTNMQEMKITVETYFEEVQRLRTLLDSAERSNKAESKESRRQNKTLSTTVLRLTKTVQQLEEENQELKKELTQEEMSMTDSPACRAKGYMDWSKQRLVRRILELEKRLERMKNLQITKASQKSLDDTESTNQNAETEPSMITENDVLLNGVVTKLGEQKSELKLKLTQRDEEIRRLSAEKDERLKEVENVLKEQIRNHESLIQTHRQEMSALIVEITCLKEKLEEERNLKVVQDPIQVRDSSSLSTEPSSPSDFGTKKKNKAAEIIQKHWRSHRKRDLVLLQSCLRGHLIRQRHLEGQKQADLGTVPASMSQSGKSTQAVQEEEVTLLQSVFRAHLKRSTMNTDRAQSVSSIHQNKQHVLPAGSSQAVFTSKTQSSGVKIHQQEPATEIPKSVDSDDSDDIIVSPSRPPRKKEQPFSCFPFSADDLI", "length": 680 }, "evidence": [ { "id": "A0AAA9TAL9", "url": "https://omabrowser.org/oma/group/A0AAA9TAL9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6IPM2-1", "protein_name": "IQ domain-containing protein E", "gene_name": "IQCE", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLGTGEPALDTGDDSLSAVTFDSDVETKAKRKAFHKPPPTSPKSPYLSKPRKVASWRSLRTAGSMPLGGRASLTPQKLWLGTAKPGSLTQALNSPLTWEHAWTGVPGGTPDCLTDTFRVKRPHLRRSASNGHVPGTPVYREKEDMYDEIIELKKSLHVQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGTDFVRTLAEKRPDASWVINGLKQRILKLEQQCKEKDGTISKLQTDMKTTNLEEMRIAMETYYEEVHRLQTLLASSETTGKKPLGEKKTGAKRQKKMGSALLSLSRSVQELTEENQSLKEDLDRVLSTSPTISKTQGYVEWSKPRLLRRIVELEKKLSVMESSKSHAAEPVRSHPPACLASSSALHRQPRGDRNKDHERLRGAVRDLKEERTALQEQLLQRDLEVKQLLQAKADLEKELECAREGEEERREREEVLREEIQTLTSKLQELQEMKKEEKEDCPEVPHKAQELPAPTPSSRHCEQDWPPDSSEEGLPRPRSPCSDGRRDAAARVLQAQWKVYKHKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQSSPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGDDVNSDDSDDIVIAPSLPTKNFPV", "length": 695 }, "evidence": [ { "id": "A0AAA9TAL9", "url": "https://omabrowser.org/oma/group/A0AAA9TAL9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PCQ0-1", "protein_name": "IQ domain-containing protein E", "gene_name": "Iqce", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLGTTDIASETGDDSLSAITFESDIESKTKRKSFHKPPSTSPKSPYYSKPRKVTSWRSLKTAGSMPLSSRMSLTPQKLWLGSSKQGSVAQPPSPTLTSEHAWTHPPSCTPDYLTEAVRAKRADLRRSGSHGHVSGTSVYREKEDMYDEIIELKKSLHMQKSDVDLMRTKLRRLEEENSRKDRQIEQLLDPSRGPDFVRTLAEKKPDTGWVITGLKQRIFRLEQQCKEKDNTINKLQTDMKTTNLEEMRIAMETYYEEIHRLQTLLASSEATGKKPMVEKKLGVKRQKKMSSALLNLTRSVQELTEENQSLKEDLDRMLSNSPTISKIKGYGDWSKPRLLRRIAELEKKVSSSESPKQSTSELVNPNPLVRSPSNISVQKQPKGDQSPEDLPKVAPCEEQEHLQGTVKSLREELGALQEQLLEKDLEMKQLLQSKIDLEKELETAREGEKGRQEQEQALREEVEALTKKCQELEEAKREEKNSFVAVTHEAHPELHAPSPCSRHSEPDSDNSAGEEGSSQPPAPCSEERREAAIRTLQAQWKAHRRKKREAALDEAATVLQAAFRGHLARSKLVRSKVPDSRSPSLPGLLSPLNQSSPAPRVLSPISPAEENPTQEEAVIVIQSILRGYLAQARFIASCCREIAASSQRETVSLTPSGSASPPSLRASPGVIRKELCASEELRETSASEPAPSVPYSAQGGHGDCPSSSSLEAVPSMKDAMCEERSSSPRSAGPSLAEPSPPELQPLSPPPVEDICSDDSDDIIFSPFLPRKKSPSPF", "length": 778 }, "evidence": [ { "id": "A0AAA9TAL9", "url": "https://omabrowser.org/oma/group/A0AAA9TAL9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 485, 692 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 308, "end_pos": 310 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAT3-1", "uniprot_ac": "A0AAA9TAT3", "uniprot_id": "A0AAA9TAT3_BOVIN", "mass": { "chemical_mass": 38791.0, "monoisotopic_mass": 38791.0 }, "refseq": {}, "gene_names": [ { "name": "UBFD1", "type": "recommended", "evidence": [ { "id": "A0AAA9TAT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3" } ] } ], "protein_names": [ { "name": "Ubiquitin domain-containing protein UBFD1", "type": "recommended", "evidence": [ { "id": "A0AAA9TAT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBFD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3", "locus": { "chromosome": "25", "start_pos": 21249033, "end_pos": 21108511, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046033", "url": "https://www.ensembl.org/id/ENSBTAG00000046033" } ] } } ], "crossref": [ { "id": "A0AAA9TAT3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046033", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046033", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17047", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17047", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "G3MZF7", "url": "https://www.orthodb.org/?gene=G3MZF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16470", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16470", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16470:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16470:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00240", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00240", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25343", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25343", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SUJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZF7", "url": "https://www.uniprot.org/uniprotkb/G3MZF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZF7-1", "url": "https://www.uniprot.org/uniprotkb/G3MZF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRRRVSIETSTCFRPGCARLGAAAGANLSQLAFSRRPLRERWVLYTIIMAAAGAPDGMEEPGMDTEAETEAPARSLNCVEAEAAAGAAAEDSCAARGNLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPAVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF", "length": 356, "header": "tr|A0AAA9TAT3-1|A0AAA9TAT3_BOVIN Isoform 1 of Ubiquitin domain-containing protein UBFD1 OS=Bos taurus OX=9913 GN=UBFD1 PE=1 SV=1 CANONICAL=A0AAA9TAT3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3/entry#A0AAA9SUJ4-1", "sequence": { "sequence": "MAAAGAPDGMEEPGMDTEAETEAPARSLNCVEAEAAAGAAAEDSCAARGNLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPAVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKGVSVGPHGSLLLLGVLGSNSICGCNQRHCAGEMAVFLKALSPLAQETDPK", "length": 292, "header": "tr|A0AAA9SUJ4-1|A0AAA9TAT3_BOVIN Computationally mapped isoform of Ubiquitin domain-containing protein UBFD1 OS=Bos taurus OX=9913 GN=UBFD1 PE=1 SV=1 CANONICAL=A0AAA9TAT3-1" }, "locus": { "chromosome": "25", "start_pos": 21240376, "end_pos": 21228719, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089154.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089154.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086815.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086815.1" } ] } }, { "isoform_ac": "A0AAA9TAT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3/entry#A0AAA9TAT3-1", "sequence": { "sequence": "MGRRRRVSIETSTCFRPGCARLGAAAGANLSQLAFSRRPLRERWVLYTIIMAAAGAPDGMEEPGMDTEAETEAPARSLNCVEAEAAAGAAAEDSCAARGNLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKQHRKVLDKGKPEDVMPSVKGAQERLPAVPLSGMYNKSGGKVRLTFKLEQDQLWIGTKERTEKLPMGSIKNVVSEPIEGHEDYHMMAFQLGPTEASYYWVYWVPTQYVDAIKDTVLGKWQYF", "length": 356, "header": "tr|A0AAA9TAT3-1|A0AAA9TAT3_BOVIN Isoform 1 of Ubiquitin domain-containing protein UBFD1 OS=Bos taurus OX=9913 GN=UBFD1 PE=1 SV=1 CANONICAL=A0AAA9TAT3-1" }, "locus": { "chromosome": "25", "start_pos": 21240335, "end_pos": 21108515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118744.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118744.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093993.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093993.1" } ] } }, { "isoform_ac": "A0AAA9TFR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3/entry#A0AAA9TFR0-1", "sequence": { "sequence": "MAAAGAPDGMEEPGMDTEAETEAPARSLNCVEAEAAAGAAAEDSCAARGNLQPAPAQPPGDPAAQASVSNGEDAGGGAGRELVDLKIIWNKTKHDVKFPLDSTGSELKQKIHSITGLPPAMQKVMYKGLVPEDKTLREIKVTSGAKIMVVGSTINDVLAVNTPKDAAQQDAKAEENKKEPLCRQKGP", "length": 187, "header": "tr|A0AAA9TFR0-1|A0AAA9TFR0_BOVIN Computationally mapped isoform of Ubiquitin domain-containing protein UBFD1 OS=Bos taurus OX=9913 GN=UBFD1 PE=1 SV=1 CANONICAL=A0AAA9TAT3-1" }, "locus": { "chromosome": "25", "start_pos": 21230878, "end_pos": 21228719, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110251.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110251.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096996.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096996.1" } ] } }, { "isoform_ac": "A0AAA9TNA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT3/entry#A0AAA9TNA6-1", "sequence": { "sequence": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45930:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842259", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SWD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYY2", "url": "https://www.uniprot.org/uniprotkb/F1MYY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYY2-1", "url": "https://www.uniprot.org/uniprotkb/F1MYY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAAGRRMRGAPARLLLPLLLPWLLLLTPETRGAPGCPVPIRSCKCSGERPKGLSGGAPNPARRRVVCGGGDLPEPPDPGLLPNSTVTLLLSNNKITGLRSGAFLGLSLLEKLDLRNNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSGTFQGLPRLLRLNISGNIFSSLQPGVFDELPALKAVDFGTEFLTCDCHLRWLLPWAQNRSLQLSERTLCAYPSALHAQALAGLQEAQLRCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGVLLADSLVHDCTFITSELTLSHIGVWASGEWECSVSTVQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREAGMPGTRHAGPGQSPSPETEPLADQQLRFRCTTGRPNVSLSAFHIKNSVALASIQLPPSLFSTPPAALAPPAPPDCTLQLLVFRNGRLFRTLGNTSRPGATGPGRRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPMAAWWSQEGPGGPGGWRSEGCQLRSSQPNVSSLHCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPPEGDAAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYLDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQSPKGVTGRVSLEPGEELRGSTRLRSSGPLLSDSGSLLAAGSTGVVTPGPPEDGDGLYSPGVQLGALVTTHFLYLATWACGALTVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACRPPASGSRASPRAAPAGPEDGSPVFGEGPPSLKSSPSGSSGHAQPPGPCKLTNLQLAQSQACEAGAAARGDGEPELPGPRAGLGPRHPNNLHHGRRGHKSRAKGHRAGEAGGKNRLRALRGGAAGTAELQSSESGSPHHSPSESYLGSSRHSPGVGPRLEGEAALTPSEGSDTSAAPPPEAGRPSQRRSASRDNLRGGVLEKESKRRSYPLNSASLNGAPKGGKYDDVPSSGAEAAGGGCMKTGLWKSETTV", "length": 1335, "header": "tr|A0AAA9TCM9-1|A0AAA9TCM9_BOVIN Isoform 1 of Adhesion G protein-coupled receptor A2 OS=Bos taurus OX=9913 GN=ADGRA2 PE=3 SV=1 CANONICAL=A0AAA9TCM9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9/entry#A0AAA9SWD2-1", "sequence": { "sequence": "MGAAGRRMRGAPARLLLPLLLPWLLLLTPETRGAPGCPVPIRSCKCSGERPKGLSGGAPNPARRRVVCGGGDLPEPPDPGLLPNSTVTLLLSNNKITGLRSGAFLGLSLLEKLDLRNNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSGTFQGLPRLLRLNISGNIFSSLQPGVFDELPALKAVDFGTEFLTCDCHLRWLLPWAQNRSLQLSERTLCAYPSALHAQALAGLQEAQLRCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGVLLADSLVHDCTFITSELTLSHIGVWASGEWECSVSTVQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPPEGDAAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYLDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQSPKGVTGRVSLEPGEELRGSTRLRSSGPLLSDSGSLLAAGSTGVVTPGPPEDGDGLYSPGVQLGALVTTHFLYLATWACGALTVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACRPPASGSRASPRAAPAGPEDGSPVFGEGPPSLKSSPSGSSGHAQPPGPCKLTNLQLAQSQACEAGAAARGDGEPELPGPRAGLGPRHPNNLHHGRRGHKSRAKGHRAGEAGGKNRLRALRGGAAGTAELQSSESGSPHHSPSESYLGSSRHSPGVGPRLEGEAALTPSEGSDTSAAPPPEAGRPSQRRSASRDNLRGGVLEKESKRRSYPLNSASLNGAPKGGKYDDVPSSGAEAAGGGCMKTGLWKSETTV", "length": 1118, "header": "tr|A0AAA9SWD2-1|A0AAA9TCM9_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Bos taurus OX=9913 GN=ADGRA2 PE=3 SV=1 CANONICAL=A0AAA9TCM9-1" }, "locus": { "chromosome": "27", "start_pos": 33105431, "end_pos": 33070364, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109259.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109259.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087539.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087539.1" } ] } }, { "isoform_ac": "A0AAA9TCM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9/entry#A0AAA9TCM9-1", "sequence": { "sequence": "MGAAGRRMRGAPARLLLPLLLPWLLLLTPETRGAPGCPVPIRSCKCSGERPKGLSGGAPNPARRRVVCGGGDLPEPPDPGLLPNSTVTLLLSNNKITGLRSGAFLGLSLLEKLDLRNNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSGTFQGLPRLLRLNISGNIFSSLQPGVFDELPALKAVDFGTEFLTCDCHLRWLLPWAQNRSLQLSERTLCAYPSALHAQALAGLQEAQLRCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGVLLADSLVHDCTFITSELTLSHIGVWASGEWECSVSTVQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREAGMPGTRHAGPGQSPSPETEPLADQQLRFRCTTGRPNVSLSAFHIKNSVALASIQLPPSLFSTPPAALAPPAPPDCTLQLLVFRNGRLFRTLGNTSRPGATGPGRRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPMAAWWSQEGPGGPGGWRSEGCQLRSSQPNVSSLHCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPPEGDAAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYLDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQSPKGVTGRVSLEPGEELRGSTRLRSSGPLLSDSGSLLAAGSTGVVTPGPPEDGDGLYSPGVQLGALVTTHFLYLATWACGALTVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACRPPASGSRASPRAAPAGPEDGSPVFGEGPPSLKSSPSGSSGHAQPPGPCKLTNLQLAQSQACEAGAAARGDGEPELPGPRAGLGPRHPNNLHHGRRGHKSRAKGHRAGEAGGKNRLRALRGGAAGTAELQSSESGSPHHSPSESYLGSSRHSPGVGPRLEGEAALTPSEGSDTSAAPPPEAGRPSQRRSASRDNLRGGVLEKESKRRSYPLNSASLNGAPKGGKYDDVPSSGAEAAGGGCMKTGLWKSETTV", "length": 1335, "header": "tr|A0AAA9TCM9-1|A0AAA9TCM9_BOVIN Isoform 1 of Adhesion G protein-coupled receptor A2 OS=Bos taurus OX=9913 GN=ADGRA2 PE=3 SV=1 CANONICAL=A0AAA9TCM9-1" }, "locus": { "chromosome": "27", "start_pos": 33105431, "end_pos": 33070364, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135127.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135127.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093883.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093883.1" } ] } }, { "isoform_ac": "A0AAA9TY61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9/entry#A0AAA9TY61-1", "sequence": { "sequence": "MCSRNTYWMRDLRNNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSGTFQGLPRLLRLNISGNIFSSLQPGVFDELPALKAVDFGTEFLTCDCHLRWLLPWAQNRSLQLSERTLCAYPSALHAQALAGLQEAQLRCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGVLLADSLVHDCTFITSELTLSHIGVWASGEWECSVSTVQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREAGMPGTRHAGPGQSPSPETEPLADQQLRFRCTTGRPNVSLSAFHIKNSVALASIQLPPSLFSTPPAALAPPAPPDCTLQLLVFRNGRLFRTLGNTSRPGATGPGRRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPMAAWWSQEGPGGPGGWRSEGCQLRSSQPNVSSLHCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPPEGDAAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYLDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQSPKGVTGRVSLEPGEELRGSTRLRSSGPLLSDSGSLLAAGSTGVVTPGPPEDGDGLYSPGVQLGALVTTHFLYLATWACGALTVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACRPPASGSRASPRAAPAGPEDGSPVFGEGPPSLKSSPSGSSGHAQPPGPCKLTNLQLAQSQACEAGAAARGDGEPELPGPRAGLGPRHPNNLHHGRRGHKSRAKGHRAGEAGGKNRLRALRGGAAGTAELQSSESGSPHHSPSESYLGSSRHSPGVGPRLEGEAALTPSEGSDTSAAPPPEAGRPSQRRSASRDNLRGGVLEKESKRRSYPLNSASLNGAPKGGKYDDVPSSGAEAAGGGCMKTGLWKSETTV", "length": 1232, "header": "tr|A0AAA9TY61-1|A0AAA9TY61_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Bos taurus OX=9913 GN=ADGRA2 PE=3 SV=1 CANONICAL=A0AAA9TCM9-1" }, "locus": { "chromosome": "27", "start_pos": 33105431, "end_pos": 33089116, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098588.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098588.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103584.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103584.1" } ] } }, { "isoform_ac": "F1MYY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9/entry#F1MYY2-1", "sequence": { "sequence": "MGAAGRRMRGAPARLLLPLLLPWLLLLTPETRGAPGCPVPIRSCKCSGERPKGLSGGAPNPARRRVVCGGGDLPEPPDPGLLPNSTVTLLLSNNKITGLRSGAFLGLSLLEKLDLRNNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSGTFQGLPRLLRLNISGNIFSSLQPGVFDELPALKAVDFGTEFLTCDCHLRWLLPWAQNRSLQLSERTLCAYPSALHAQALAGLQEAQLRCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGVLLADSLVHDCTFITSELTLSHIGVWASGEWECSVSTVQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREAGMPGTRHAGPGQSPSPETEPLADQQLRFRCTTGRPNVSLSAFHIKNSVALASIQLPPSLFSTPPAALAPPAPPDCTLQLLVFRNGRLFRTLGNTSRPGATGPGRRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPMAAWWSQEGPGGPGGWRSEGCQLRSSQPNVSSLHCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPPEGDAAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYLDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQSPKGVTGRVSLEPGEELRGSTRLRSSGPLLSDSGSLLAAGSTGVVTPGPPEDGDGLYSPGVQLGALVTTHFLYLATWACGALTVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACRPPASGSRASPRAAPAGPEDGSPVFGEGPPSLKSSPSGSSGHAQPPGPCKLTNLQLAQSQACEAGAAARGDGEPELPGPRAGLGPRHPNNLHHGRRGHKSRAKGHRAGEAGGKNRLRALRGGAAGTAELQSSESGSPHHSPSESYLGSSRHSPGVGPRLEGEAALTPSEGSDTSAAPPPEAGRPSQRRSASRDNLRGGVLEKESKRRSYPLNSASLNGAPKGGKYDDVPSSGAEAAGGGCMKTGLWKKPLSHPILANQGA", "length": 1343, "header": "tr|F1MYY2-1|F1MYY2_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor A2 OS=Bos taurus OX=9913 GN=ADGRA2 PE=3 SV=3 CANONICAL=A0AAA9TCM9-1" }, "locus": { "chromosome": "27", "start_pos": 33105952, "end_pos": 33070364, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011608.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011608.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011608.6", "url": "https://www.ensembl.org/id/ENSBTAP00000011608.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616111", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616111", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G7Z0-1", "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "Adgra2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPRPALGRPGLPLSTPLARSGPSSRRTVRPLRCRSPRGDGLMGAGGRRMPVRSARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPDLKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTQIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGVQPSSPGQDVPLEPEALADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNTSRPGTAEPSKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGTDPLAAWWNQDGPGGWSSEGCKLRFSQPNVSSLYCQHLGNVAVLMELSAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPPEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRGHVAQNPKQGNSRLSLEPGEDPRGSTRLRSSGVLLSDSGSLLATVSAGVGTPAPPEESDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHAPPRALPTAAEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASMVARGDGEPEPTGSRSSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAQIPETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGCMKTGLWKSETTV", "length": 1378 }, "evidence": [ { "id": "A0AAA9TCM9", "url": "https://omabrowser.org/oma/group/A0AAA9TCM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0Z9U4-1", "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "ADGRA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQLYAVMPQALTQPWVPPAHCHHGTVPPQGCRVPHIIPRPCHLATGPAVPTPPAPWILGLLHHSPYNSTSLSPPSLCSHPHRLLSNNKITVLQNGSFFGLRVLEKLDLKNNLISTVQPGAFLGLPELKRLDLSNNRIGCLSASVFQGLTNLLRLNMSGNIFSSLPPGVFDELPSLKVVDFATEYLTCDCNLRWVLPWARNYSVQISERTLCVYPRHLHTTPLRSAQESQLQCAGTPELHTHHLIPSLRQVVFQGDRLPFQCTATYLDNSTQIHWYHNQQRVQEDERAGVIVEESLIHDCTFITSELILSNIHVSANGEWECAVSTSQGNVSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAFQSCLQYPFASGPASGGPAAEKQASRRCDRAGRWEEGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAANFSDMVDVLYVAQMIEKFIGYVDQIKQLTDVIVEMASNIMLVDDHILWMSQKEEKACTSIVRSLERIAAHTLSSNSQHMAVNSRNIAFEAYVVKPESYVGLSCVAFQRRDGGPPGRTALAEQAAEPQPDQQLRLRCTTGRPNISLSSFHIKNSIALASIQLPPSLFASPVPPAPLADCKLQLLVFRNGKLFCSTGNSSRLADDGKRRSVATPVIYAGTYGCSIGNLTEPVAVSLRHPGEGADPVAAYWNFEVLGGMGGWSAEGCQLAAREPNVTSLHCRHLSNVAVLMELSGFPSEARGPVEVLHPAMYTCTAVLLLCLFTTIITYIVHHGTIHITRKCWHMLLNLCFHMAMTSAVFAGGITLTGYLVVCQAVGIILHYSSLSTLLWMVVKARVLYKEATWKAPRQPDGDSAPPAPRPMLRFYLIAGGIPLIICGITAAVNIHNYHDNNPYCWLVWRPSLGAFYVPVAFILLVTWLYLLCAGLSLQCHAPRRKEPPELPGTLPRLGANGELLTDSGSISVTLHSGTHCPEVDGVYSLQAQLWALLAVHAMYVALWTFGAMAVSQRGDLNVVFSCLYGVTAVALGLFIFIHHCVRRRDVLGSWFSCCPSYRSALPMQPYSHPGTAAVEDGSQMFIGCDPEAARSATSSSSPSSAGSAAGRCKLTNLRAAQSQAEGPEHGDGRSAGAGRHSNNHRRNHKSRTKQHREGKHHRLKVLRGPSSEQSESGSVHNSHSESYHSSRNSPMNNCAAPRAAGPQDGEVAPGQSEGSDGFVEARRRSRDNVRQAEREAKRRSYPLNVGSHNGGLKGSKYDVNLAGADSGAGMRSGLWKSETTV", "length": 1282 }, "evidence": [ { "id": "A0AAA9TCM9", "url": "https://omabrowser.org/oma/group/A0AAA9TCM9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FBY6-1", "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "adgra2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGPCVRIPFWVRVFLLLLLYRIAAGCPELFSSGCSCTEDRSKAHPTPGTRRKVSCGGKELTETPEVSLLPNRTVSLNLSNNRIRMLKNGSFAGLSSLEKLDLRNNLISTIMPGAFLGLTALRKLDLSSNRIGCLTPEMFQGLTNLTKLNISGNIFSSLDPNVFMELHSLKLVNFHSEFLSCDCGLRWVPSFFRSGSARLGDETLCAYPRRLQNKPLRLLRESDLSCEGPLELHTLSLLPSQRQVVFKGDRLPFHCTASLVDKITALHWRQNGQPVTSDPTKGIHLEESVQHDCTFITSELILSNVHVEASGEWECVVSTGRGNTSCSVEIVVLENSASFCPEQKVNNNRGEFRWPRTLAGITSYQHCLQLRYPSLTLGGGVEQKKASRNCDRSGRWEEADYSQCLYTNDITRILHTFILMPVNASNAVTLAHQVRSYTLEAAGFTDTVDVLYVAQMMHKFMDYVTELRELSEVLVEMGSNLMQVDDQILARAQREERACSSIVYTLETLAWPQLHSHAQDLSRYSRNIVMEAHLIRPAHFTGISCTVYQRREGAAGSQVHDGADLSLEQQLRFRCTTGTHNTSLNAFHLKNAVALATVSLPATLFPPNAPPDCKLQFVAFRNGRFFPFTSNFTGHSDLARRRGISTPVIYAGLDGCSMWNQSDPIIVSLRHTSPGHDPVAAHWNSQALGHHGSWSLDGCQLIHSDVSISTLRCSVLSNYAVLQEIPDFPGSPSIPVEVLHPVIYTCTAVLLLCLFTIIITYILHHSSIRITRKSWHTLLNTSFHVAMTSAVFAGGITLTGYPIVCQAVGIVLHYSSLSTLLWIGVSARVIYKEALLRTPQQLEGESAVQPTQRPMLRFYLIAGGVPLIICGITAAVNINNYGDNIPYCWLVWQPSFGAFYIPAGLIILVTWIYFLCTVFCLRQRNFQESKDLQCSASDPSNLPESQPALSGSTSLLSTDSGVSPVHAGTTVEDQYSLKVQCLALMATQFVFVGLWCCGAMAVWHVDRERKLFSCLYGGTATGLGIFLVLHHCFKRLDVQAAWLGCCPGYHRSQPMPAYSHPCTVTVGVQSASERGSQLFVACHPPTDPNHYSSSARSSSTQSGTASITVVPSKLTNLLQVSQDNANNASRAPAGTNTNTSTSTENNKPTNNLLPSLLPVQQPQRRKACSRTKGGNTQYHHRGDARSHYRLKALRAGGGGSMGALGPSGTEHSNIYHVHKHASSENGSLRNSHSEGQNGLLTNGRHRGEGLATSPSEGSDGGSSGSRKPFPLLPSVARRAAMQQNAQCRSASKDNLKLAAAAERESKRSSFPLNMSSNVTATASLSTVSAPNGTLKGSVVELDTSGTDQSQGSVGMKSRVWKSETTV", "length": 1367 }, "evidence": [ { "id": "A0AAA9TCM9", "url": "https://omabrowser.org/oma/group/A0AAA9TCM9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91ZV8-1", "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "Adgra2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAGGRRMPVPPARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPALKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTRIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGAQPSSVGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGADPMAAWWNQDGPGGWSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPLEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRSHVAQNPKQGNRISLEPGEELRGSTRLRSSGVLLNDSGSLLATVSAGVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHVPARALPTATEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASVAARGDGEPEPTGSRGSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAPIAETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGSMKTGLWKSETTV", "length": 1336 }, "evidence": [ { "id": "A0AAA9TCM9", "url": "https://omabrowser.org/oma/group/A0AAA9TCM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PE1-1", "protein_name": "Adhesion G protein-coupled receptor A2", "gene_name": "ADGRA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV", "length": 1338 }, "evidence": [ { "id": "A0AAA9TCM9", "url": "https://omabrowser.org/oma/group/A0AAA9TCM9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "regulation of angiogenesis", "id": "GO:0045765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "regulation of chemotaxis", "id": "GO:0050920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050920", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" }, { "name": "Wnt signalosome", "id": "GO:1990909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990909", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 602, "end_pos": 604, "annotation": "n_glycosylation_sequon" }, { "start_pos": 659, "end_pos": 661, "annotation": 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taurus OX=9913 GN=ERAS PE=3 SV=1 CANONICAL=A0AAA9T9T1-1" }, "locus": { "chromosome": "X", "start_pos": 86938449, "end_pos": 86935261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108119.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108119.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088992.1" } ] } }, { "isoform_ac": "A0AAA9T9T1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1/entry#A0AAA9T9T1-1", "sequence": { "sequence": "MAQPTKPDMFDLGLGTWSPRSREQSHRAWGSPSKGVGKKLPEYKAVVVGASGVGKSALTIQLNNQCFVEDHDPTIQDSYWKEMALDHGGCILNVLDTAGQATHQALRDQCVAIGDGVLGVFALDDPSSLAQLQQMRATWGPHHTQPLVLVGNKCDLVTTTGDARAAAAALAKSWGAPFVETSAKTRQGVVEAFSLLIQEIQRVREAMAKEATTGPGGDKGRHQKAMCHCGCSVA", "length": 234, "header": "tr|A0AAA9T9T1-1|A0AAA9T9T1_BOVIN Isoform 1 of small monomeric GTPase OS=Bos taurus OX=9913 GN=ERAS PE=3 SV=1 CANONICAL=A0AAA9T9T1-1" }, "locus": { "chromosome": "X", "start_pos": 86938449, "end_pos": 86937748, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154694.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154694.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106124.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106124.1" } ] } }, { "isoform_ac": "E1BEP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1/entry#E1BEP6-1", "sequence": { "sequence": "MEGTVVGWTCPSLLGSGRRQRFMPGGGVPYHLTLAVGTVASPFPRHPAVVCVTSGQSSPLTPKPRCSSSSLHGSLSPGDPRPERRRLAPGPVSGPAVHISSLSCPLGAMAQPTKPDMFDLGLGTWSPRSREQSHRAWGSPSKGVGKKLPEYKAVVVGASGVGKSALTIQLNNQCFVEDHDPTIQDSYWKEMALDHGGCILNVLDTAGQATHQALRDQCVAIGDGVLGVFALDDPSSLAQLQQMRATWGPHHTQPLVLVGNKCDLVTTTGDARAAAAALAKSWGAPFVETSAKTRQGVVEAFSLLIQEIQRVREAMAKEATTGPGGDKGRHQKAMCHCGCSVA", "length": 342, "header": "tr|E1BEP6-1|E1BEP6_BOVIN Computationally mapped isoform of small monomeric GTPase OS=Bos taurus OX=9913 GN=ERAS PE=3 SV=2 CANONICAL=A0AAA9T9T1-1" }, "locus": { "chromosome": "X", "start_pos": 86938449, "end_pos": 86935745, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017619.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017619.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017619.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017619.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:540065", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540065", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9T1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9T1" } ], "pmid": "" }, { "name": "G protein activity", "id": "GO:0003925", "url": 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[ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SZE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNYKAIGKIGEGTFSEVMKIQNLRDGNHYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILTLHQVVFDRKSGSLALICELMDMNIYELIRGRRHPLSEKKVRHYMYQLCKSLDHMHRNGIFHRDVKPENILVKRDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYGFKMDLWSAGCVLYEMASLQPLFPGANELDQISRIHDVMGTPAEKTLTKFKQSRAMSFDFPFKKGSGIPLLTTSLSPQCLSLLHAMVAYDPDERITAHQALQHPYFQEQRAAEKQALARARWKASAPFPECPTAPELSSAWQTAQEGRKQKQPPRPEENHPRRPGPACLMELPRLKLSGAAKLASYSSPALPSVFLPKVPLLRPLKCVGAAQKTETQKDIKPSLKQYRLPTIERRGGGD", "length": 418, "header": "tr|A0AAA9TCI9-1|A0AAA9TCI9_BOVIN Isoform 1 of MAPK/MAK/MRK overlapping kinase OS=Bos taurus OX=9913 GN=MOK PE=3 SV=1 CANONICAL=A0AAA9TCI9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9/entry#A0AAA9SZE0-1", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000093837.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 312, "start_aa": "Thr", "end_pos": 312, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr312", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616277", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616277", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" }, { "name": "cyclin-dependent protein serine/threonine kinase activity", "id": "GO:0004693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004693", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" }, { "name": "ciliary base", "id": "GO:0097546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", 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"A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] 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"https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", 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"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + 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"https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { 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{ "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP48-1", "url": "https://www.uniprot.org/uniprotkb/F1MP48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ35", "url": "https://www.uniprot.org/uniprotkb/F1MQ35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ35-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLSCLWWTLSLILSLLSAYFFQQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "tr|A0AAA9TDX0-1|A0AAA9TDX0_BOVIN Isoform 1 of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=1 CANONICAL=A0AAA9TDX0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZY8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0/entry#A0AAA9SZY8-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTNEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGRGK", "length": 491, "header": "tr|A0AAA9SZY8-1|A0AAA9TDX0_BOVIN Computationally mapped isoform of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=1 CANONICAL=A0AAA9TDX0-1" }, "locus": { "chromosome": "19", "start_pos": 15159461, "end_pos": 15120628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135998.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135998.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090985.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090985.1" } ] } }, { "isoform_ac": "A0AAA9TDX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0/entry#A0AAA9TDX0-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLSCLWWTLSLILSLLSAYFFQQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 531, "header": "tr|A0AAA9TDX0-1|A0AAA9TDX0_BOVIN Isoform 1 of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=1 CANONICAL=A0AAA9TDX0-1" }, "locus": { "chromosome": "19", "start_pos": 15156294, "end_pos": 15120628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094361.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094361.1" } ] } }, { "isoform_ac": "A0AAA9TYQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0/entry#A0AAA9TYQ5-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGRGK", "length": 528, "header": "tr|A0AAA9TYQ5-1|A0AAA9TYQ5_BOVIN Computationally mapped isoform of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=1 CANONICAL=A0AAA9TDX0-1" }, "locus": { "chromosome": "19", "start_pos": 15159461, "end_pos": 15120628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133630.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133630.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102633.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102633.1" } ] } }, { "isoform_ac": "F1MP48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0/entry#F1MP48-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG", "length": 486, "header": "tr|F1MP48-1|A0AAA9TDX0_BOVIN Computationally mapped isoform of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=2 CANONICAL=A0AAA9TDX0-1" }, "locus": { "chromosome": "19", "start_pos": 15156294, "end_pos": 15120628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027104.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027104.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027104.3", "url": "https://www.ensembl.org/id/ENSBTAP00000027104.3" } ] } }, { "isoform_ac": "F1MQ35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0/entry#F1MQ35-1", "sequence": { "sequence": "MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREILLDVARTSLQTKVHPQLADVLTEAVVDSVLAVRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVAIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGIHTERNRQKSLPL", "length": 437, "header": "tr|F1MQ35-1|A0AAA9TDX0_BOVIN Computationally mapped isoform of Chaperonin containing TCP1 subunit 6B OS=Bos taurus OX=9913 GN=CCT6B PE=3 SV=1 CANONICAL=A0AAA9TDX0-1" }, "locus": { "chromosome": "19", "start_pos": 15154367, "end_pos": 15120628, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047729.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047729.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044907.2", "url": "https://www.ensembl.org/id/ENSBTAP00000044907.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-390471", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390471", "resource": "Reactome", "description": "Association of TriC/CCT with target proteins during biosynthesis" }, { "id": "R-BTA-6814122", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6814122", "resource": "Reactome", "description": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" }, { "name": "unfolded protein binding", "id": "GO:0051082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" }, { "name": "ATP-dependent protein folding chaperone", "id": "GO:0140662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140662", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "chaperonin-containing T-complex", "id": "GO:0005832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005832", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", 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"ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": 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{ "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": 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"ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": 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"activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": 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"url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": 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"evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": 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fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": 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"activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": 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], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytokine activity", "id": "GO:0005125", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005125", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TA58-1", "uniprot_ac": "A0AAA9TA58", "uniprot_id": "A0AAA9TA58_BOVIN", "mass": { "chemical_mass": 82662.0, "monoisotopic_mass": 82662.0 }, "refseq": {}, "gene_names": [ { "name": "KLHDC7A", "type": "recommended", "evidence": [ { "id": "A0AAA9TA58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58" } ] } ], "protein_names": [ { "name": "Kelch domain containing 7A", "type": "synonym", "evidence": [ { "id": "A0AAA9TA58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHDC7A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58", "locus": { "chromosome": "2", "start_pos": 134157039, "end_pos": 134192372, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030322", "url": "https://www.ensembl.org/id/ENSBTAG00000030322" } ] } } ], "crossref": [ { "id": "A0AAA9TA58", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TA58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030322", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030322", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530171", "url": "https://www.ncbi.nlm.nih.gov/gene/530171", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530171", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530171", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GTNFFHI", "url": "https://omabrowser.org/oma/group/GTNFFHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45972:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45972:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T410", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T410", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T410-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T410-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA58", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX28", "url": "https://www.uniprot.org/uniprotkb/G3MX28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX28-1", "url": "https://www.uniprot.org/uniprotkb/G3MX28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPRGGGAEAQDWHLDMQLTGQLVLSAAALLLLTAAYKLYKSRPAQALPRGADAKAEAEAEGGGSGQPAAQEAVPGAPWWDLRRRRGSKGTTGPPGCSWERTEASRVPATGASSATSEAGEAGKAGRKHAGEEHAGQCPDSDLPAPRCGDQEAGTAVDGKPELPHRPHQCSEPPSPPAGLPAMESGRVGGELTPRQDSGPPKHPGSGEQESPHEGEVAHREGQCDMNNTWVFTHASGVHREEAAALQAASDLGLALRQREGASDASYTFSSMARVRVEENFIPEKVEGIRPRLKGKVYDYHVEYTSQATSRSRLAPGTAASAGAPAPESVSGPLGTRIASGRPAGDGEGRQETAASPGSDPSGSTRGFSRKESLLQILENPEFQLQLDSFGDAAPSCPDQRAAPTRPTSQDSPESSSAGSRGKPHVHSVAGTSFFHPPLSPGSALEVHLDLGNCYQALAFAKRKKLEPLKEAAYKVMRDNYLQVLRSPDIYGRLSGAERELVLQRRLRGREHLVVADVCPQDGSGRLCCYDDERDAWRPLARLPPEAVSRGCAICSLFNYLFLVSGCQGSGLQPSNRVFCYNPLTDIWSEVCPLNQARPHCRLVALDGQLYAVGGECLNTVERYDPRLDRWTFAPPLPKDTFALAHTAAASGGELFVTGGSLRYLLLRFSVREQRWRAAPTGGGRDRTAEMVAVRGFLYRFDLNRSLGISVYRCSASARLWYECATYRTPYPEAFQCAVVDELVYCVGRRRTLRFLADSISPRDLSGT", "length": 768, "header": "tr|A0AAA9TA58-1|A0AAA9TA58_BOVIN Isoform 1 of Kelch domain containing 7A OS=Bos taurus OX=9913 GN=KLHDC7A PE=4 SV=1 CANONICAL=A0AAA9TA58-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T410-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58/entry#A0AAA9T410-1", "sequence": { "sequence": "MLPRGGGAEAQDWHLDMQLTGQLVLSAAALLLLTAAYKLYKSRPAQALPRGADAKAEAEAEGGGSGQPAAQEAVPGAPWWDLRRRRGSKGTTGPPGCSWERTEASRVPATGASSATSEAGEAGKAGRKHAGEEHAGQCPDSDLPAPRCGDQEAGTAVDGKPELPHRPHQCSEPPSPPAGLPAMESGRVGGELTPRQDSGPPKHPGSGEQESPHEGEVAHREGQCDMNNTWVFTHASGVHREEAAALQAASDLGLALRQREGASDASYTFSSMARVRVEENFIPEKVEGIRPRLKGKVYDYHVEYTSQATSRSRLAPGTAASAGAPAPESVSGPLGTRIASGRPAGDGEGRQETAASPGSDPSGSTRGFSRKESLLQILENPEFQLQLDSFGDAAPSCPDQRAAPTRPTSQDSPESSSAGSRGKPHVHSVAGTSFFHPPLSPGSALEVHLDLGNCYQALAFAKRKKLEPLKEAAYKVMRDNYLQVLRSPDIYGRLSGAERELVLQRRLRGREHLVVADVCPQDGSGRLCCYDDERDAWRPLARLPPEAVSRGCAICSLFNYLFLVSGCQGSGLQPSNRVFCYNPLTDIWSEVCPLNQARPHCRLVALDGQLYAVGGECLNTVERYDPRLDRWTFAPPLPKDTFALAHTAAASGGELFVTGGSLRYLLLRFSVREQRWRAAPTGGGRDRTAEMVAVRGFLYRFDLNRSLGISVYRCSASARLWYECATYRTPYPEAFQCAVVDELVYCVGRRRTLRFLADSISPRFVPEMRQAFPSPQGTLLPTVLTLPGPDVPQTRV", "length": 796, "header": "tr|A0AAA9T410-1|A0AAA9TA58_BOVIN Computationally mapped isoform of Kelch domain containing 7A OS=Bos taurus OX=9913 GN=KLHDC7A PE=4 SV=1 CANONICAL=A0AAA9TA58-1" }, "locus": { "chromosome": "2", "start_pos": 134180511, "end_pos": 134180067, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134711.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134711.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090435.1" } ] } }, { "isoform_ac": "A0AAA9TA58-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58/entry#A0AAA9TA58-1", "sequence": { "sequence": "MLPRGGGAEAQDWHLDMQLTGQLVLSAAALLLLTAAYKLYKSRPAQALPRGADAKAEAEAEGGGSGQPAAQEAVPGAPWWDLRRRRGSKGTTGPPGCSWERTEASRVPATGASSATSEAGEAGKAGRKHAGEEHAGQCPDSDLPAPRCGDQEAGTAVDGKPELPHRPHQCSEPPSPPAGLPAMESGRVGGELTPRQDSGPPKHPGSGEQESPHEGEVAHREGQCDMNNTWVFTHASGVHREEAAALQAASDLGLALRQREGASDASYTFSSMARVRVEENFIPEKVEGIRPRLKGKVYDYHVEYTSQATSRSRLAPGTAASAGAPAPESVSGPLGTRIASGRPAGDGEGRQETAASPGSDPSGSTRGFSRKESLLQILENPEFQLQLDSFGDAAPSCPDQRAAPTRPTSQDSPESSSAGSRGKPHVHSVAGTSFFHPPLSPGSALEVHLDLGNCYQALAFAKRKKLEPLKEAAYKVMRDNYLQVLRSPDIYGRLSGAERELVLQRRLRGREHLVVADVCPQDGSGRLCCYDDERDAWRPLARLPPEAVSRGCAICSLFNYLFLVSGCQGSGLQPSNRVFCYNPLTDIWSEVCPLNQARPHCRLVALDGQLYAVGGECLNTVERYDPRLDRWTFAPPLPKDTFALAHTAAASGGELFVTGGSLRYLLLRFSVREQRWRAAPTGGGRDRTAEMVAVRGFLYRFDLNRSLGISVYRCSASARLWYECATYRTPYPEAFQCAVVDELVYCVGRRRTLRFLADSISPRDLSGT", "length": 768, "header": "tr|A0AAA9TA58-1|A0AAA9TA58_BOVIN Isoform 1 of Kelch domain containing 7A OS=Bos taurus OX=9913 GN=KLHDC7A PE=4 SV=1 CANONICAL=A0AAA9TA58-1" }, "locus": { "chromosome": "2", "start_pos": 134190663, "end_pos": 134157276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094906.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094906.1" } ] } }, { "isoform_ac": "G3MX28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA58/entry#G3MX28-1", "sequence": { "sequence": "MLPRGGGAEAQDWHLDMQLTGQLVLSAAALLLLTAAYKLYKSRPAQALPRGADAKAEAEAEGGGSGQPAAQEAVPGAPWWDLRRRRGSKGTTGPPGCSWERTEASRVPATGASSATSEAGEAGKAGRKHAGEEHAGQCPDSDLPAPRCGDQEAGTAVDGKPELPHRPHQCSEPPSPPAGLPAMESGRVGGELTPRQDSGPPKHPGSGEQESPHEGEVAHREGQCDMNNTWVFTHASGVHREEAAALQAASDLGLALRQREGASDASYTFSSMARVRVEENFIPEKVEGIRPRLKGKVYDYHVEYTSQATSRSRLAPGTAASAGAPAPESVSGPLGTRIASGRPAGDGEGRQETAASPGSDPSGSTRGFSRKESLLQILENPEFQLQLDSFGDAAPSCPDQRAAPTRPTSQDSPESSSAGSRGKPHVHSVAGTSFFHPPLSPGSALEVHLDLGNCYQALAFAKRKKLEPLKEAAYKVMRDNYLQVLRSPDIYGRLSGAERELVLQRRLRGREHLVVADVCPQDGSGRLCCYDDERDAWRPLARLPPEAVSRGCAICSLFNYLFLVSGCQGSGLQPSNRVFCYNPLTDIWSEVCPLNQARPHCRLVALDGQLYAVGGECLNTVERYDPRLDRWTFAPPLPKDTFALAHTAAASGGELFVTGGSLRYLLLRFSVREQRWRAAPTGGGRDRTAEMVAVRGFLYRFDLNRSLGISVYRCSASARLWYECATYRTPYPEAFQCAVVDELVYCVGRRRTLRFLADSISPRLSILLAEGNGNLLQYSCLENPMDRGAWWAAVHGVVKSWTRLSDFTFTFHFHAL", "length": 816, "header": "tr|G3MX28-1|G3MX28_BOVIN Computationally mapped isoform of Kelch domain containing 7A OS=Bos taurus OX=9913 GN=KLHDC7A PE=4 SV=3 CANONICAL=A0AAA9TA58-1" }, "locus": { "chromosome": "2", "start_pos": 134190663, "end_pos": 134159158, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042815.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042815.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054087.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054087.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530171", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530171", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3AAU5-1", "protein_name": "Kelch domain containing 7A", "gene_name": "IGSF21", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQWVTVLWQSDMQLTGKLVLSAASLLLLTLAYRFYKSRSAPGGNNPTTDACREKGRRENAAPDGQNVEGLRHRWVFGARSGGDAQASVPDPRQKRERILPANEEKDGGKAKSHGFRDLNEMLNGEESGGNGHSMLVPHIILPNQTAGDGGAQSTEQDLASGIASKEGSRGTIQTLSVTSELGVNITASYREADTSHSFSSIAKIQVEESYIAERKTKDGDGQLSPGLRGKVYDYYIQSISHSVSTKKSLPSPFMGTALSCSSEHVREELQCLERVNEELQRSAGVNKKLQNFAALLPDTHSQETTVALQDPTTSLTVSSNVESLEKDPKPSAPTRSISRKNSVLQIAENSHLQLPLGGFCVTPANMPPASAQLDLVDKTNFFKTSPSSLDTHLDLGNCYEVLCRAKAEKLDFLQEAAYKVMSDNYLQVLRTPSIYCRLKASERDLILRRRMKGKMCVVVADISTQLGLYASRLCCYDDEGDRWHNLCHVPPEVVSQGCAMCSMFNYLFVVAGCEGLGRTPSNRVFCYNPLTNIWREICPLNQARPHCKLVALDGCLYAIGGECLYTVERYDPRYDRWVFIAPLPHDTFAVAHTATVCDGEIYVTGGTLRYVLLRYIAREDIWTVSPAGGGKDRTVEVVSVNGFVYRFDYNCSMGISVYRCRAKAKLWYECATHAKAYPACFQCAVMGSLVHCIGRHFHIRFLADPVSPRFGTKELRPFPSPRGSLIPVVLVLPWAGMEQTWV", "length": 743 }, "evidence": [ { "id": "A0AAA9TA58", "url": "https://omabrowser.org/oma/group/A0AAA9TA58/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LJZ7-1", "protein_name": "Kelch domain containing 7A", "gene_name": "Klhdc7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPTRKGTEAHDWHLDMQLTSKVVLSAAALLLVTVAYKLYKSRPAPAPHAGRKKERHKAENETEGLGQPAFQEAPPGTLPRGPRRRKASKGAGSPLDYSLEDPGDSYILDTPRSEEPTRKGSDESQDRQRPDSQQVPPPCGGQEAGTAVRGKPNPPHPLHSGCEPTSSPARLIPGVGGSCVGDNLSPWPDSRPLEETGSGDPEAPNCWTDPTLVNGDMNQSWIFTHMTGVSRGEAGALQAAANMGLATQQQEGATSASHTFSSVARIRMEENVIQKAEGPELKGRIYDYFVESTSKAVSRPVPCAAALADAAPSPGPGPEPLVTGAATRDQADNTAGGTLQVASPQPVPSPSAPGFGRKVSLLQIAENPELQLQPEGFRMPLPAHLDQSAQLGSDCSHGEPHVQLVAGTNFFHIPLTPASALDVRLDLGNCYEMLTLAKRQGLEALKEAAYKVLSDNYLQVLRSTDIYGGLSGAERELILQRRFRGHKCLVVADMCPQEDSGRLCCYDNVQDAWHPLAQLPLEAMSRGCALCSLFNYLFVVSGCQGPAGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEGYLYAIGGECLNTVERYDPRLDRWTFAPPLPNDTFALAHTATVCANEIFVTGGSLRYLLLRFSAQEQRWWAGPTAGSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCNASTRLWYECATYRLPYPDAFQCAVVDDRIYCVGRRRTLCFLADHISPRFVPNELQGFPAARGTLLPAVLTLPVPDVPQTPV", "length": 773 }, "evidence": [ { "id": "A0AAA9TA58", "url": "https://omabrowser.org/oma/group/A0AAA9TA58/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2APT9-1", "protein_name": "Kelch domain-containing protein 7A", "gene_name": "Klhdc7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPTGEGAEGQDWHLDMQLPSKVVLSAAALLLVTAAYKLYKSRPAPVGQAGRNNKDHKAENETEALGQLAFQEAPPGTLPRGRRRRKASKGAGTSLDYSLVDPEDPCILDISRSEEATRKGSDESQGRQCPDSQQVPPPCGGQEAGTDVRGKPNPPHLPHSGCEPTSSSGRLIPGVGGSCVGDKLSPWPDSRPPEETGSGDLEAPNGWTDLTLVNGDMNQSWIFTHMTGVSRGEAGVLQAAADMGLATQQQEGATNASHTFSSVARIRMEENIIQKAEGPGLKGRVYDYFVESTSKADSRPVPCPAALADAPSPGPGPEPLVTGAASRDEAANTAGGGASEAASPQPVASPSAPGFSRKVSLLQIAENPELQLQPEGFRMPLPAHLDQRAQLSSACSHGEPHVQLVAGTNFFHIPLTPASALDVRLDLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPDIYGGLSGAERELILQRRFRGHKRLVVADMCPQDDSGRLCCYDNVQDAWHPLAQLPPEAMSRGCALCTLFNYLFVVSGCQEPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEGHLYAIGGECLNTVERYDPRLDRWTFAPPLPNDTFALAHTATVCANEIFVTGGSLRYLLLRFSTQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCSASTRLWYECATYRLPYPDAFQCAVVDDHIYCVGRRRMLCFLADHISPRFVSKELKGFPSARGTLLPAVLTLPVPDVPQTPV", "length": 773 }, "evidence": [ { "id": "A0AAA9TA58", "url": "https://omabrowser.org/oma/group/A0AAA9TA58/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3HXK2-1", "protein_name": "Kelch domain-containing protein 7A", "gene_name": "Klhdc7a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLPTRAGAETHDWHLDMQLTSKVVLSAAALLLVTAAYKLYKSRPVPAGQAGRSNKGHKADCEAEGLGEVAFQGAPPGTLPRGPRRRKASRGAGIPLDCSLEDPGDSCQPVTSRSGESTRKGSDENQEGQRPESQHVSPPCGGQEAGTAVRGKPYPPHLPQLGCEPTSSPARLAPGVGGSCVGDKLSPWPDGRPPDQTGSGDPGAPNCCTDPTVVSSDMDQSWVFTHVTGVNKGEAGALQAAADMGLATQQREGATNASYTFSSVARIRMEENIIQKAEGPGPKLKGRVYDYFVESTSKAVSRPIPCSAALADAPSPGPGPEPLVTGADSRGQADNPEGAAEVMSPPPVPSPSAPGFSRKVSLLQIADNPELQLQPEGFTMPAPAHLDQEAQINSACSHGEPRVQLVAGTNFFHIQLTPASAQDVRLDLGNCYEVLTLAKRQGLEALKEAAYKVMSDNYLQVLRSTDIYGGLSGTERELILQRRFRGHKCLVVADVCPQEDSGRLCCYDNVQDAWHFLAQLPMEAMSQGCAVCTLFNYLFVVSGCQGPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEGCLYAIGGECLNTVERYDPRVDRWTFAPPLPNDTFALAHTATVCANEIFVTGGSLRYLLLRFSTQEQRWWASPTGGSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCSASTRFWYECATYRLPYPDAFQCAVVEDHIYCVGRRRMFCFLADHISPRFVPKELQGFPAARGTLLPAVLSLPVTDVPQTPV", "length": 773 }, "evidence": [ { "id": "A0AAA9TA58", "url": "https://omabrowser.org/oma/group/A0AAA9TA58/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5VTJ3-1", "protein_name": "Kelch domain-containing protein 7A", "gene_name": "KLHDC7A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEAEGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRKGSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSCAGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALEAASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQAIFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGFSRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPLTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV", "length": 777 }, "evidence": [ { "id": "A0AAA9TA58", "url": "https://omabrowser.org/oma/group/A0AAA9TA58/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 704, "end_pos": 706 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAB1-1", "uniprot_ac": "A0AAA9TAB1", "uniprot_id": "A0AAA9TAB1_BOVIN", "mass": { "chemical_mass": 61209.0, "monoisotopic_mass": 61209.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9TAB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1", "locus": {} } ], "crossref": [ { "id": "A0AAA9TAB1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd17374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7U0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALEELLDKVGGLGKFQILQMALTFPFYMIVVCHSLLENFTAAVPGHHCWVHNLDNATVSDNDTGILSPDVLLRISIPLDSNFKPEKCRRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVFDHSLFSFTIVTEWDLVCDHQSQKSMVQSLFMAGMLVGSFIYGHLSDRFGRKLILRCCLLQLAISGICAAFAPTFLIYCLLRFWSGCSAVAIVSNNSMLIVAWVRAQSKATVITLIACALSIGQMMLGGLAFVFREWRTLQLVVSVPFFVFFLSSRERAFSLTLLWEPGMKMWLVESARWLIITNKPDEGLKGLRIVAHRNGMKNAEATLNMEGLRATMQEQLEAAQTKTTVFDLFRTPNLCKRICLLSFARFANTVPYFGIFMNLQHFGSNIFLFQVIFGALTISARCLALLVLNHMGCRLTQMLLMFLVGLSILANMFVPQEMQTLRLTLASVGMGCVAAAVASNSVHNSELMPTLLRAKASGLNMMASRCGAALAPLLMTVVVYLPTLPWIIYGVCLILAGLLILLLPETRNMPLLDTIQDVENK", "length": 549, "header": "tr|A0AAA9TAB1-1|A0AAA9TAB1_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9TAB1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1/entry#A0AAA9T7U0-1", "sequence": { "sequence": "MALEELLDKVGGLGKFQILQMALTFPFYMIVVCHSLLENFTAAVPGHHCWVHNLDNATVSDNDTGILSPDVLLRISIPLDSNFKPEKCRRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVFDHSLFSFTIVTEWDLVCDHQSQKSMVQSLFMAGMLVGSFIYGHLSDRFGRKLILRCCLLQLAISGICAAFAPTFLIYCLLRFWSGFVAWVRAQSKATVITLIACALSIGQMMLGGLAFVFREWRTLQLVVSVPFFVFFLSSRERAFSLTLLWEPGMKMWLVESARWLIITNKPDEGLKGLRIVAHRNGMKNAEATLNMEVSREEEVVIGLEGRNKLILAFSLLRYTNPFLTRAHFGSNIFLFQVIFGALTISARCLALLVLNHMGCRLTQMLLMFLVGLSILANMFVPQEMQTLRLTLASVGMGCVAAAVASNSVHNSELMPTLLRAKASGLNMMASRCGAALAPLLMTVVVYLPTLPWIIYGVCLILAGLLILLLPETRNMPLLDTIQDVENK", "length": 516, "header": "tr|A0AAA9T7U0-1|A0AAA9TAB1_BOVIN Computationally mapped isoform of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9TAB1-1" }, "locus": { "chromosome": "29", "start_pos": 41381823, "end_pos": 41366042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091919.2", "url": "https://www.ensembl.org/id/ENSBTAP00000091919.2" } ] } }, { "isoform_ac": "A0AAA9TAB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1/entry#A0AAA9TAB1-1", "sequence": { "sequence": "MALEELLDKVGGLGKFQILQMALTFPFYMIVVCHSLLENFTAAVPGHHCWVHNLDNATVSDNDTGILSPDVLLRISIPLDSNFKPEKCRRFLHPQWQLLHLNGTFPNMTDLDTEPCVDGWVFDHSLFSFTIVTEWDLVCDHQSQKSMVQSLFMAGMLVGSFIYGHLSDRFGRKLILRCCLLQLAISGICAAFAPTFLIYCLLRFWSGCSAVAIVSNNSMLIVAWVRAQSKATVITLIACALSIGQMMLGGLAFVFREWRTLQLVVSVPFFVFFLSSRERAFSLTLLWEPGMKMWLVESARWLIITNKPDEGLKGLRIVAHRNGMKNAEATLNMEGLRATMQEQLEAAQTKTTVFDLFRTPNLCKRICLLSFARFANTVPYFGIFMNLQHFGSNIFLFQVIFGALTISARCLALLVLNHMGCRLTQMLLMFLVGLSILANMFVPQEMQTLRLTLASVGMGCVAAAVASNSVHNSELMPTLLRAKASGLNMMASRCGAALAPLLMTVVVYLPTLPWIIYGVCLILAGLLILLLPETRNMPLLDTIQDVENK", "length": 549, "header": "tr|A0AAA9TAB1-1|A0AAA9TAB1_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9TAB1-1" }, "locus": { "chromosome": "29", "start_pos": 41381823, "end_pos": 41366042, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098911.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098911.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093558.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093558.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAB1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAB1" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 536, "start_aa": "Trp", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 107, "end_pos": 109 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9V5-1", "uniprot_ac": "A0AAA9T9V5", "uniprot_id": "A0AAA9T9V5_BOVIN", "mass": { "chemical_mass": 63709.0, "monoisotopic_mass": 63709.0 }, "refseq": {}, "gene_names": [ { "name": "SCRN3", "type": "recommended", "evidence": [ { "id": "A0AAA9T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ] } ], "protein_names": [ { "name": "Secernin 3", "type": "synonym", "evidence": [ { "id": "A0AAA9T9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCRN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5", "locus": { "chromosome": "2", "start_pos": 22365327, "end_pos": 22397619, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012966", "url": "https://www.ensembl.org/id/ENSBTAG00000012966" } ] } } ], "crossref": [ { "id": "A0AAA9T9V5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9V5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012966", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012966", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CYYDVSD", "url": "https://omabrowser.org/oma/group/CYYDVSD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFJ9", "url": "https://www.orthodb.org/?gene=F1MFJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12994:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12994:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03577", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03577", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T8D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFJ9", "url": "https://www.uniprot.org/uniprotkb/F1MFJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFJ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLAKDFPILEAELEYATPRSESNVNKLCRLTGTAPPVAVGTSGVKGDDFRQLAPLHPFSLLSPFTWVARRPVKKKMEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKGTWIQSLGPGRFHLLRASCTLVPQLLNTTAREATSTRSLHTTARVAPAGHNSRKRGCINKDPAQPKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTEKAKTMLDNMRKLEKELFKEMESVLQNKHLQVDKIVNLLHQCTEDEIRIYKSNVSS", "length": 564, "header": "tr|A0AAA9T9V5-1|A0AAA9T9V5_BOVIN Isoform 1 of Secernin 3 OS=Bos taurus OX=9913 GN=SCRN3 PE=3 SV=1 CANONICAL=A0AAA9T9V5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5/entry#A0AAA9T8D4-1", "sequence": { "sequence": "MKLAKDFPILEAELEYATPRSESNVNKLCRLTGTAPPVAVGTSGVKGDDFRQLAPLHPFSLLSPFTWVARRPVKKKMEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTARILERVAISPSMGSFEPRIELTSPVSPALAGQFSTTEPPGKPLYYF", "length": 489, "header": "tr|A0AAA9T8D4-1|A0AAA9T9V5_BOVIN Computationally mapped isoform of Secernin 3 OS=Bos taurus OX=9913 GN=SCRN3 PE=3 SV=1 CANONICAL=A0AAA9T9V5-1" }, "locus": { "chromosome": "2", "start_pos": 22397420, "end_pos": 22374505, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105696.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105696.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094220.1" } ] } }, { "isoform_ac": "A0AAA9T9V5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5/entry#A0AAA9T9V5-1", "sequence": { "sequence": "MKLAKDFPILEAELEYATPRSESNVNKLCRLTGTAPPVAVGTSGVKGDDFRQLAPLHPFSLLSPFTWVARRPVKKKMEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKGTWIQSLGPGRFHLLRASCTLVPQLLNTTAREATSTRSLHTTARVAPAGHNSRKRGCINKDPAQPKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTEKAKTMLDNMRKLEKELFKEMESVLQNKHLQVDKIVNLLHQCTEDEIRIYKSNVSS", "length": 564, "header": "tr|A0AAA9T9V5-1|A0AAA9T9V5_BOVIN Isoform 1 of Secernin 3 OS=Bos taurus OX=9913 GN=SCRN3 PE=3 SV=1 CANONICAL=A0AAA9T9V5-1" }, "locus": { "chromosome": "2", "start_pos": 22397420, "end_pos": 22365728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120713.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120713.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093415.1" } ] } }, { "isoform_ac": "F1MFJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5/entry#F1MFJ9-1", "sequence": { "sequence": "MKLAKDFPILEAELEYATPRSESNVNKLCRLTGTAPPVAVGTSGVKGDDFRQLAPLHPFSLLSPFTWVARRPVKKKMEPCSCDTFVALPPATIDNRIIFGKNSDRPCDEVQEVVYFPAAVHDNLKEHLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREKVCDEEALLGMDLVRLGLERGDTAEKALNVIVDLLEKYGQGGNCSEGRMVFSYHNSFLIADRNEAWILETAGKYWAAEKVEEGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKKEFDFAATYSYLDTAKMMISPGRYCEGYKLLNKHKGNITFETMVEILRDKPSGINMEGEFLTTASMVSILPQDSKLPCIHFFTGTPDPERSVFKPFIFVPNISQLLNTSSPTFELEDSVGKKLQFNSKPDRRHPLYQKHQQALEILDNKTEKAKTMLDNMRKLEKELFKEMESVLQNKHLQVDKIVNLLHQCTEDEIRIYKSNVSS", "length": 498, "header": "tr|F1MFJ9-1|A0AAA9T9V5_BOVIN Computationally mapped isoform of Secernin 3 OS=Bos taurus OX=9913 GN=SCRN3 PE=3 SV=3 CANONICAL=A0AAA9T9V5-1" }, "locus": { "chromosome": "2", "start_pos": 22397420, "end_pos": 22365728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017239.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017239.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017239.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017239.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K189-1", "protein_name": "Secernin 3", "gene_name": "Scrn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQPYSCDTFVALPPATVGNRVIFGKNSDRLFDEVQEVIYFPAAVHSDLEKRLKCTYIEVDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAIWGREDISKEEALLGMDLVRLGLERADTAEKALNVIVDLLGKYGQGGNCAEGEEFSYYNSFLIADRNEAWILETSGKFWAAEKVQGVRNISNQFSITTKIDREHPDMRNYAKQRGWWDGKEEFDFAAAYSYTDTATMMTSPSRYCQGHKLLNKHKGNITYETMVEILRDRPSGINMKGEFLTTASMVSILPQDPSLPCIHLLTGTPHPERSVFKPFIFVPHVSPLLDTKSPTFELERPVAKKPYVKPDRRHLLYQNHQQALEMISNHKEKGKTILDNVRKLEKEVFEEIESILQNRHLDMDKTVNLFPQYVRDEIKIYQPNISS", "length": 418 }, "evidence": [ { "id": "A0AAA9T9V5", "url": "https://omabrowser.org/oma/group/A0AAA9T9V5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0ZRJ5-1", "protein_name": "Secernin 3", "gene_name": "SCRN3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAARPPPRSCDTFVALPPAAAGGRVVFGKNSDRPSDEVQEVLYVPAAAHPAGAQLECTYITVEQAEQTYAVVLSRPSWLWGAEMGANEHGVCIGNEAVWGREEVCDAEALLGMDLVRLGLERADTAEKALTVIVDLLEKYGQGGNCMESHMAFTYHNSFLIADRKEAWVLETSGKHWAAEKVEGGVRNISNQLSITTKIDREHPEMREYAKSKGWWDGEKEFDFAATYSYVNTARMTTSRSRYCEGYKLLNKHKGAITAETMMEILRDKESGINMEGGFMTTGSMVSVLPQDPNLPCIHFFTGTPDPARSVFKPFIFVPGITELLKTSSPTFGPDDPVKKQPRFQSKPDRRHELYKKHESAAVVMETMKGKGKKMLEEIQTLEKRKMSEMESILQNGCTDINQPVNLFSQCVDEELKIYG", "length": 420 }, "evidence": [ { "id": "A0AAA9T9V5", "url": "https://omabrowser.org/oma/group/A0AAA9T9V5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IJH6-1", "protein_name": "Secernin-3 isoform X1", "gene_name": "Scrn3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPYSCDTFVALPPATVGNRVIFGKNSDRLFDEVQEVIYFPAAVHNDLQKRLKCTYIEIDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREDISKEEALLGMDLVRLGLERADTAEKALDVIVDLLEKYGQGGNCAEGEEFSYYNSFLIADRNEAWILETSGKYWAAEKVQGVRNISNQLSITTKIDREHPNMRNYAKHKGWWDGKEDFDFTAAYSYMNTASMMTSSSRYCQGYKLLNKHKGNITFETMMEILRDEPSGINMKGEFLTTSSMVSILPRDSSLACIHFFTGTPHPERSVFKPFIFVPNISQLLDTKSPTFDLERPMAKKPYVKPDRRHPLYQKHQQAWEVISNSKEKSKTTLDDMRKLEKEVFEEMESILQNKHLDVDKTVNLFTQCVKDEIKIYQSNISS", "length": 418 }, "evidence": [ { "id": "A0AAA9T9V5", "url": "https://omabrowser.org/oma/group/A0AAA9T9V5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TMH2-1", "protein_name": "Secernin-3", "gene_name": "Scrn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPYSCDTFVALPPATVGNRVIFGKNSDRLFDEVQEVIYCPAAVHNDLEKRLKCTYIEVDQVPETYAVVLSRPAWLWGAEMGANEHGVCIGNEAVWGREDISKEEALLGMDLVRLGLERADTAEKALDVIVDLLEKYGQGGNCAEGKEFSYYNSFLIADRNEAWILETSGKYWAAERVQGVRNISNQLSITTKIDREHPDMRNYAKQRGWWDGKEEFDFTAAYSYIDTAAMMTSPSRYCQGYKLLDKHRGNITFETMMEILRDRPSGINMKGEFLTTASMVSVLPQDPSLPCIHLFTATPHPERSVFKPFIFVPHISPLLDTKSPTFEPERPVAKKPYVKPDRRHPLYQKHQEALEMISNSKEKGKTILDKMRKLEKAVSEEIESILQSGHLDEEKTVNLFPQYVKDEIKIYQSNISS", "length": 418 }, "evidence": [ { "id": "A0AAA9T9V5", "url": "https://omabrowser.org/oma/group/A0AAA9T9V5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VI64-1", "protein_name": "Secernin-3", "gene_name": "Dmel\\CG10098", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTNGDCFVVLPENCAEGTLIIGRNAEDEKNVNVASEVCFYDATEVLEGKTDGGASAETGGDMLRVILQKPQPGLWGGDFGANERGVALGLTWAAGENEAKDSDSLLGTDIVRLTLAVAKDVDDAVDRIGALVASHGHDNSKLNFIACDAAAAWLVSCSGKVWAAEKLEASFLRLPSGGLAVTTVVNKSSEGLDDAASFAAAHDAEAQAPAVDWCGPKPAGDGTYTQHDMFETLRSASNASSSRAATVSVLSVKGISCHWFTGTPNAAESVFKPFVFAPNPRISPLTQVQAEADLTLLHKLHSQRKPAALEHLRSLELSCVDELNNYFSLQDHASDELDELLKDCVEAEVKFYR", "length": 353 }, "evidence": [ { "id": "A0AAA9T9V5", "url": "https://omabrowser.org/oma/group/A0AAA9T9V5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ], "pmid": "" }, { "name": "detection of temperature stimulus involved in sensory perception of pain", "id": "GO:0050965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dipeptidase activity", "id": "GO:0016805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ], "pmid": "" }, { "name": "cysteine-type exopeptidase activity", "id": "GO:0070004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070004", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9V5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 395, "end_pos": 397, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 561, "end_pos": 563, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 156, "end_pos": 158 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 395, "end_pos": 397 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 506, "end_pos": 508 }, { "start_pos": 561, "end_pos": 563 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAD7-1", "uniprot_ac": "A0AAA9TAD7", "uniprot_id": "A0AAA9TAD7_BOVIN", "mass": { "chemical_mass": 83045.0, "monoisotopic_mass": 83045.0 }, "refseq": { "ac": "NP_001179809", "name": "N-acetylated-alpha-linked acidic dipeptidase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179809" }, "gene_names": [ { "name": "NAALAD2", "type": "recommended", "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ] }, { "name": "NAALAD2", "type": "synonym", "evidence": [ { "id": "NP_001179809", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179809" } ] } ], "protein_names": [ { "name": "N-acetylated-alpha-linked acidic dipeptidase 2", "type": "recommended", "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#names_and_taxonomy" } ] }, { "name": "3.4.17.21", "type": "synonym", "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#names_and_taxonomy" } ] }, { "name": "Glutamate carboxypeptidase III", "type": "synonym", "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#names_and_taxonomy" } ] }, { "name": "N-acetylated-alpha-linked acidic dipeptidase 2", "type": "synonym", "evidence": [ { "id": "NP_001179809", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179809" } ] }, { "name": "N-acetylated-alpha-linked acidic dipeptidase II", "type": "synonym", "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T8Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Y5#function" }, { "database": "UniProtKB", "id": "ARBA00057657", "url": "https://www.uniprot.org/uniprotkb/ARBA00057657#function" }, { "database": "UniProtKB", "id": "A0AAA9TA38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA38#function" }, { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NAALAD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7", "locus": { "chromosome": "29", "start_pos": 5097620, "end_pos": 5149224, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000284", "url": "https://www.ensembl.org/id/ENSBTAG00000000284" } ] } } ], "crossref": [ { "id": "A0AAA9TAD7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08022", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08022", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536439", "url": "https://www.ncbi.nlm.nih.gov/gene/536439", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003137", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003137", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046450", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046450", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536439", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536439", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TEWMEEY", "url": "https://omabrowser.org/oma/group/TEWMEEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGS8", "url": "https://www.orthodb.org/?gene=F1MGS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10404:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10404:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8963693", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963693", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179809", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Y5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Y5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Y5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS8", "url": "https://www.uniprot.org/uniprotkb/F1MGS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS8-1", "url": "https://www.uniprot.org/uniprotkb/F1MGS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSGRRPYLWIFLAAALASFLAGFTVGWLSKPLKDTATSADSHQNLRWKLISEMKADNIKSFLRSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIFLRYLGGIASPDESWKGGLNVSYNIGPGFVGHDSFRKVRMHVYNINKITRIYNVIGTIRGSVEPDRYVILGGHRDSWVFGGIDPTSGAATLQEVAQSFGKLLSSGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERSVAYINSDSSIEGNYTLRVDCTPLLHQLVYKLTKEISSPDDGFESKSLYESWLAKDPSSESKTLPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDTYSSYPIYHTIYETFELVEKFYDPTFKKQLAVAQLRGALVYELADAKIIPFNIQDYAKTLENYARSIYNSSRKHEQACRGHGVSFESLFSAVQNFSEAASDFHRRLSQVDLNNPMVVRIMNDQLMFLERAFIDPLGLPGRPFYRHIIFAPSSRNKYAGESFPGIFDAMFDIENKADPHSAWKEVKKHISIAAFTIQAAAGTLKEFL", "length": 740, "header": "tr|A0AAA9TAD7-1|A0AAA9TAD7_BOVIN Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=3 SV=1 CANONICAL=A0AAA9TAD7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8Y5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#A0AAA9T8Y5-1", "sequence": { "sequence": "MIRVKKFISSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIFLRYLGGIASPDESWKGGLNVSYNIGPGFVGHDSFRKVRMHVYNINKITRIYNVIGTIRGSVEPDRYVILGGHRDSWVFGGIDPTSGAATLQEVAQSFGKLLSSGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERSVAYINSDSSIEGNYTLRVDCTPLLHQLVYKLTKEISSPDDGFESKSLYESWLAKDPSSESKTLPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDTYSSYPIYHTIYETFELVEKFYDPTFKKQLAVAQLRGALVYELADAKIIPFNIQDYAKTLENYARSIYNSSRKHEQACRGHGVSFESLFSAVQNFSEAASDFHRRLSQVDLNNPMVVRIMNDQLMFLERAFIDPLGLPGRPFYRHIIFAPSSRNKYAGESFPGIFDAMFDIENKADPHSAWKEVKKHISIAAFTIQAAAGTLKEFL", "length": 684, "header": "tr|A0AAA9T8Y5-1|A0AAA9TAD7_BOVIN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=3 SV=1 CANONICAL=A0AAA9TAD7-1" }, "locus": { "chromosome": "29", "start_pos": 5140864, "end_pos": 5097740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114110.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114110.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093300.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093300.1" } ] } }, { "isoform_ac": "A0AAA9TA38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#A0AAA9TA38-1", "sequence": { "sequence": "MNSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIFLRYLGGIASPDESWKGGLNVSYNIGPGFVGHDSFRKVRMHVYNINKITRIYNVIGTIRGSVEPDRYVILGGHRDSWVFGGIDPTSGAATLQEVAQSFGKLLSSGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERSVAYINSDSSIEGNYTLRVDCTPLLHQLVYKLTKEISSPDDGFESKSLYESWLAKDPSSESKTLPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDTYSSYPIYHTIYETFELVEKFYDPTFKKQLAVAQLRGALVYELADAKIIPFNIQDYAKTLENYARSIYNSSRKHEQACRGHGVSFESLFSAVQNFSEAASDFHRRLSQVDLNNPMVVRIMNDQLMFLERAFIDPLGLPGRPFYRHIIFAPSSRNKYAGESFPGIFDAMFDIENKADPHSAWKEVKKHISIAAFTIQAAAGTLKEFL", "length": 677, "header": "tr|A0AAA9TA38-1|A0AAA9TA38_BOVIN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=3 SV=1 CANONICAL=A0AAA9TAD7-1" }, "locus": { "chromosome": "29", "start_pos": 5139812, "end_pos": 5097740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092121.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092121.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095569.1" } ] } }, { "isoform_ac": "A0AAA9TAD7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#A0AAA9TAD7-1", "sequence": { "sequence": "MATSGRRPYLWIFLAAALASFLAGFTVGWLSKPLKDTATSADSHQNLRWKLISEMKADNIKSFLRSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIFLRYLGGIASPDESWKGGLNVSYNIGPGFVGHDSFRKVRMHVYNINKITRIYNVIGTIRGSVEPDRYVILGGHRDSWVFGGIDPTSGAATLQEVAQSFGKLLSSGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERSVAYINSDSSIEGNYTLRVDCTPLLHQLVYKLTKEISSPDDGFESKSLYESWLAKDPSSESKTLPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDTYSSYPIYHTIYETFELVEKFYDPTFKKQLAVAQLRGALVYELADAKIIPFNIQDYAKTLENYARSIYNSSRKHEQACRGHGVSFESLFSAVQNFSEAASDFHRRLSQVDLNNPMVVRIMNDQLMFLERAFIDPLGLPGRPFYRHIIFAPSSRNKYAGESFPGIFDAMFDIENKADPHSAWKEVKKHISIAAFTIQAAAGTLKEFL", "length": 740, "header": "tr|A0AAA9TAD7-1|A0AAA9TAD7_BOVIN Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=3 SV=1 CANONICAL=A0AAA9TAD7-1" }, "locus": { "chromosome": "29", "start_pos": 5148929, "end_pos": 5097740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126608.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126608.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093592.1" } ] } }, { "isoform_ac": "A0AAA9TZI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#A0AAA9TZI2-1", "sequence": { "sequence": "MATSGRRPYLWIFLAAALASFLAGFTVGWLSKPLKDTATSADSHQNLRWKLISEMKADNIKSFLRSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKGTSSLLQAAATNMLVNHFLASLMLCLILKIKQILIQPGKK", "length": 305, "header": "tr|A0AAA9TZI2-1|A0AAA9TZI2_BOVIN Computationally mapped isoform of N-acetylated alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=4 SV=1 CANONICAL=A0AAA9TAD7-1" }, "locus": { "chromosome": "29", "start_pos": 5148929, "end_pos": 5097808, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102137.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102137.1" } ] } }, { "isoform_ac": "F1MGS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7/entry#F1MGS8-1", "sequence": { "sequence": "MATSGRRPYLWIFLAAALASFLAGFTVGWLSKPLKDTATSADSHQNLRWKLISEMKADNIKSFLRSFTKLPHLAGTEQNLLLAKKIQNQWKKFGLDSAELVHYDVLLSYPNETNANYISVTDEHGIEIFNTSYIEPPPDGYENVKNIVPPYNAFSPAGVPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGRIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTVAQRGNVLNLDGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIFLRYLGGIASPDESWKGGLNVSYNIGPGFVGHDSFRKVRMHVYNINKITRIYNVIGTIRGSVEPDRYVILGGHRDSWVFGGIDPTSGAATLQEVAQSFGKLLSSGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERSVAYINSDSSIEGNYTLRVDCTPLLHQLVYKLTKEISSPDDGFESKSLYESWLAKDPSSESKTLPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDTYSSYPIYHTIYETFELVEKFYDPTFKKQLAVAQLRGALVYELADAKIIPFNIQDYAKTLENYARSIYNSSRKHEQACRGHGVSFESLFSAVQNFSEAASDFHRRLSQVDLNKHIIFAPSSRNKYAGESFPGIFDAMFDIENKADPHSAWKEVKKHISIAAFTIQAAAGTLKEFL", "length": 709, "header": "tr|F1MGS8-1|A0AAA9TAD7_BOVIN Computationally mapped isoform of N-acetylated-alpha-linked acidic dipeptidase 2 OS=Bos taurus OX=9913 GN=NAALAD2 PE=3 SV=3 CANONICAL=A0AAA9TAD7-1" }, "locus": { "chromosome": "29", "start_pos": 5148929, "end_pos": 5097740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000354.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000354.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000354.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000354.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 379, "start_aa": "Thr", "end_pos": 379, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr379", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536439", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536439", "resource": "KEGG Pathway" }, { "id": "R-BTA-8963693", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963693", "resource": "Reactome", "description": "Aspartate and asparagine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XXI1-1", "protein_name": "Glutamate carboxypeptidase 2", "gene_name": "NAALAD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARNRATLCTRLGCPALLGCFVLGFLTGWLTKPTEKKRDSSDVYQSVRQRLVDEMKAESIRLFLRSFTKLPHLAGTEQNFLLAKQIQGQWKEFGLDSAELVHYDVLLSYPSETQPNYISVIDDRGNEIFNTSSFEPPPQGYENVTDILPPYNAFSVSGTPEADLVYVNYGRTEDFFKLKREMGINCTGKIVIARYGKIFRGNKVKNAVLAGAIGIILYSDPADYYAPGVDPYPDGWNLPDRGVQRGNVLNLNGAGDPLTPGYPAKEYIYRYKVNEGVGIPKIPVHPIGYHDAEVLLYAMGGPAAPDSTWKGALNVSYNIGPGFVRNISTRKVRMHVHTNNKVARIYNVIGIIRGAVEPDRYIILGGHRDSWVFGGIDPSTGAAVLQEVARSFGKMKTEGWRPKRTIIFASWDAEEFGLLGSTEWAEENARVLQERAVAYINTDSSIEGNYTLRVDCTPLLYKLIYNLTKEISSPDEGYENKSLYDSWLEKDPAPENNSYPRINKLGSGSDFEAYFQRLGIASGRVRYTKNRKTDKFSNYPVYHTVYETFELVERFYDPTFKKQLAIAKLRGKLVYELADSQVIPFDCRDYGEALKGYSDRIYKLAKKHEEQLKTYRVSFDPLFSAVGNFSEAAAEFHRRLEHVDRKDPVAVRIMNDQLMFIERAFIDPLGLPGRKFYRHVIFAPSSHNKYAGESFPGIYDAMFDIESKTDLHGAWEEVKRQISIAAFTVQAAAETLKEVA", "length": 740 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A2Y7-1", "protein_name": "N-acetylated-alpha-linked acidic dipeptidase 2", "gene_name": "Naalad2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDFQDSGCRCRKIGLQRCSYCRPQACSCSQRHSLTQKGMARPRQLRGLGMCITAVLASFIMGFTVGWFTKPLKETTTSSAYHQSIQQKLLSEMKAENIRSFLRSFTKLPHLAGTEQNLLLAKKIQTQWKKFGLDSANLVHYDVLLSYPNETNANYVSIVDEHGAEIFKTSYLEPPPDGYENVTNIVPPYNAFSAHGMPEGELVYVNYARTEDFFKLEREMHINCTGKIVIARYGKIFRGNKVKNAMLAGAMGIILYSDPADYFAPGVQPYPKGWNLPGAAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLPVEEAVGIPNIPVHPIGYNDAERLLRNLGGTAPPDQSWKGSLNVSYNIGPGFSGSEYSRKVRMHVHNINKITRIYNVIGTIRGSTEPDRYVILGGHRDSWVFGGIDPTTGTAVLQEIARSFGKLVNGGWKPRRTIIFASWDAEEFGLLGSTEWAEENAKILQERSIAYINSDSAIEGNYTLRVDCTPLLHQLVYKVAREISSPDDGFESKSLYESWLEKDPSPENKERPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVQNFYDPTFKKQLSVAQLRGALVYELADCVVIPFNIQDYAKALKNYAASIFNLSKKHDQQLRDHGVSFDPLFSAVKNFSEAASDFHRRLTQVDLNNPTAVRIMNDQQMLLERAFIDPLGLPGRPFYRHIIFAPSSHNKYAGESFPGIYDAMFDIENKADTHLAWAEVKKHISIAAFTIQAAAGTLTDVL", "length": 778 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1STP2-1", "protein_name": "N-acetylated-alpha-linked acidic dipeptidase 2", "gene_name": "NAALAD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKSRARQYLWLCVVAALASFLGGFTVGWFSKPLKVAVTSTDSPQNLRSQLLSEMKAENIKSFLRSFTELPHLAGTEQNLLLAKKIQTQWQKFGLDSAKLVHYDVLLSYPNKTNANYISVLDEHGVEIFKTSYLEPPPEGYENVKNVVPPYNAFSPQGMPEGELIYVNYARTEDFFKLERELNINCTGKIVIARYGKIFRGNKVKNAMLAGAKGIILYSDPADYSAPGVQPYPKGWNLPGTGVQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEDGVGIPQIPVHPIGYNDAEIILRYLGGTAAPDESWKGSLNVDYNIGPGFAGHDTFRKVKMHVHNINQITRIYNVIGTIKGSVEPDRYIILGGHRDSWVFGGIDPTSGAAVLQEVAQSFGKLMSRGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKTLQERGVAYINSDSSVEGNYTLRVDCTPLLYQLVYKLTKEISSPDDGFESKSLFESWLKKDPSSENKNLPRISKLGSGSDFEAYFQRLGIASGRIRYTKNRKTDNYSSYPVYHTIYETFELVENFYDPKFKKQLAVAQLRGALVYELADSKIIPFNIQDYAKALEIYATSIYKLSKKHDQEFRHYGVSFDSLFSAVKNFSEAASDFHRRLSQVDLNNPVAVRIMNDQLMLLERAFIDPLGLPGRPFYRHIIFAPSSHNKYAGESFPGIYDAMFDIDNKADAHSAWKEVKKHISVAAFTIQAAAGTLKEFL", "length": 740 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Y228-1", "protein_name": "Probable glutamate carboxypeptidase LAMP1", "gene_name": "LAMP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSKSKSLAFVIAALSYSFFSLFSSPPKSHYHELFISTSFSDNASVALNLHTLTRRPHVAGTVANAEAAEYVRSVFTSSALKSHVVAYQVSLTYPVHRSLVLTPTDSAKPITFLLEQEKLGDNPYANEVMPTFHGYAKSGNVSGPVVYANYGRVEDFVRLKKDMGVNVSGAVVIARYGQIYRGDIVKNAYEAGAVGVVIYTDKRDYGGDEWFPASKWMPPSGVQVGTVYNGLGDPTTPGWASVDGCERLSDEAVELSGDVPLIPSLPVSAADAEVILKTVVGDVSDGDVYPVGPGPGVLNLSYIGETVIAKIENVIGVIEGEEEPDRYVILGNHRDAWTFGAVDPNSGTAVLMEIAQRLDKLQKRGWKPRRTIILCNWDAEEYGLIGSTEWVEENREMLSSRAVAYLNVDCAVSGPGFHASATPQLDELIKVAAQEVRDPDNATQTIYESWIGSSDSVVIRRLGGGGSDYASFVQHVGVPGVDMSFGRGYPVYHSMYDDFTWMEKFGDPMFQRHVAMASVLGLVALRLADEEIIPFNYTSYALELKKSAEDLENEKLGHNIDVSTLIKSIEDLSTAAKHISLEKEAIKGALKVRELNDRLMMAERALTDRDGLSERPWYKHLIYGPSKYDDYGSKSFPGVDDAIDNAKKLNTKASWENVQHQIWRVSRAIRHASLVLKGELI", "length": 681 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CZR2-1", "protein_name": "N-acetylated-alpha-linked acidic dipeptidase 2", "gene_name": "Naalad2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARPRHLRGLGMCITAVLASFIAGFTVGWFIKPLKETTTSAGYHQSIQQKLLSEMKAENIRSFLRSFTKLPHLAGTEQNLLLAKKIQTQWKKFGLDSANLVHYDVLLSYPNETNANYVSIVDEHGVEIFKTSYLEPPPDGYENVTNIIPPYNAFSASGMPEGELVYVNYARTEDFFKLEREMNINCTGKIVIARYGKIFRGNKVKNAMLAGAMGIILYSDPADYFAPDVQPYPKGWNLPGAAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLPVEEAVGIPNIPVHPIGYNDAERLLRNLGGAAPPDKSWKGSLNVSYNIGPGFTGSEYSRNIRMHVNNINKITRIYNVIGTIRGSTEPDRYVILGGHRDSWVFGGIDPTTGTAVLQEIARSFGKLVNGGWRPRRTIIFASWDAEEFGLLGSTEWAEENAKLLQERSIAYINSDSAIEGNYTLRVDCTPLLNQLVYKVAREISSPDDGFESKSLYESWLEKDPSPENKECPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVQNFYDPTFKKQLSVAQLRGALVYELADSVVIPFNIQDYAKALKNYAASIFNISKKHDQQLRNHAVSFDPLFSAVKNFSEAASDFHRRLTQVDLNNPIAVRIMNDQQMLLERAFIDPLGLPGRKFYRHIIFAPSSHNKYAGESFPGIYDAMFDIENKADPSLAWAEVKKHISIAAFTIQAAAGTLTNVL", "length": 740 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y3Q0-1", "protein_name": "N-acetylated-alpha-linked acidic dipeptidase 2", "gene_name": "NAALAD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESRGRLYLWMCLAAALASFLMGFMVGWFIKPLKETTTSVRYHQSIRWKLVSEMKAENIKSFLRSFTKLPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLSYPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPEVQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQVDLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENKANSRLAWKEVKKHISIAAFTIQAAAGTLKEVL", "length": 740 }, "evidence": [ { "id": "A0AAA9TAD7", "url": "https://omabrowser.org/oma/group/A0AAA9TAD7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" }, { "name": "dipeptidase activity", "id": "GO:0016805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016805", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" }, { "name": "carboxypeptidase activity", "id": "GO:0004180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004180", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAD7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 603, "end_pos": 605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 628, "end_pos": 630, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" }, { "id": "PF02225", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PA", "eco_id": "ECO_0000259", "start_pos": 161, "end_pos": 249, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" }, { "id": "PF04389", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04389" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M28", "eco_id": "ECO_0000259", "start_pos": 347, "end_pos": 549, "start_aa": "Asn", "end_aa": "Phe", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAD7" }, { "id": "PF04253", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04253" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transferrin receptor-like dimerisation", "eco_id": "ECO_0000259", "start_pos": 617, "end_pos": 737, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.17.21", "ec_name": "N-acetyl-L-aspartyl-L-glutamate + H2O = N-acetyl-L-aspartate + L-glutamate.", "evidence": [ { "id": "3.4.17.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.17.21" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 379 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 130, "end_pos": 132 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 449, "end_pos": 451 }, { "start_pos": 603, "end_pos": 605 }, { "start_pos": 628, "end_pos": 630 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", 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"sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9G1-1", "uniprot_ac": "A0AAA9T9G1", "uniprot_id": "A0AAA9T9G1_BOVIN", "mass": { "chemical_mass": 7598.0, "monoisotopic_mass": 7598.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Keratin associated protein 19-3", "type": "synonym", "evidence": [ { "id": "A0AAA9T9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1#function" }, { "database": "UniProtKB", "id": "ARBA00003327", "url": "https://www.uniprot.org/uniprotkb/ARBA00003327#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1", "locus": {} } ], "crossref": [ { "id": "A0AAA9T9G1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9G1", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR021743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051528", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051528", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR38140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR38140:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR38140:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T9G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHYSNHYGGLGYGYGGFGGLGFGHGCGCGSFRRLGFGSGFGGYGCGSGFGSFGYGYNHCPSFFGRYGFSSFY", "length": 73, "header": "tr|A0AAA9T9G1-1|A0AAA9T9G1_BOVIN Isoform 1 of Keratin associated protein 19-3 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T9G1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9G1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1/entry#A0AAA9T9G1-1", "sequence": { "sequence": "MSHYSNHYGGLGYGYGGFGGLGFGHGCGCGSFRRLGFGSGFGGYGCGSGFGSFGYGYNHCPSFFGRYGFSSFY", "length": 73, "header": "tr|A0AAA9T9G1-1|A0AAA9T9G1_BOVIN Isoform 1 of Keratin associated protein 19-3 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9T9G1-1" }, "locus": { "chromosome": "1", "start_pos": 5396936, "end_pos": 5396718, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100454.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100454.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092543.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TD35-1", "uniprot_ac": "A0AAA9TD35", "uniprot_id": "A0AAA9TD35_BOVIN", "mass": { "chemical_mass": 66297.0, "monoisotopic_mass": 66297.0 }, "refseq": {}, "gene_names": [ { "name": "TMEM181", "type": "recommended", "evidence": [ { "id": "A0AAA9TD35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35" } ] } ], "protein_names": [ { "name": "Transmembrane protein 181", "type": "synonym", "evidence": [ { "id": "A0AAA9TD35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TD35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM181", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35", "locus": { "chromosome": "9", "start_pos": 95045019, "end_pos": 94983625, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063575", "url": "https://www.ensembl.org/id/ENSBTAG00000063575" } ] } } ], "crossref": [ { "id": "A0AAA9TD35", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TD35", "database": "AlphaFoldDB", "categories": [] }, { "id": "614300", "url": "https://www.ncbi.nlm.nih.gov/gene/614300", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR054077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR054077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614300", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614300", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31918:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31918:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T9G2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTPFRQPRAFLDSHGRSHAEMETLWKERVAELTRCPLRWAQGPCTPPPPRRGPSPRRAASAHVTRPRVALGESPGAGAPRAAVPPAPPAAAAVSAPSPPGAEGRAAAMEPLAPMRLYTLSKHHFVLVFVVFFVCFGLTVFVGIRGPKVIQTSAANFSLNNSKKLKPIQIFSKPLSTYNQQLWLTCVVELDQSKETSIQTTFTMTVKVDGVAQDGTTKFIHNKVHNRTRTLTCAEKCAEIIVAHLSYLNYTKYTVTVGFEHLKRPIKEMNFTWKTYDPAFSHLEIWFRFVFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSILLPLLLLYNDPFFPLSFLVNSWFPGMLDDLFQSVFLCALLLFWLCVYHGVRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGVKVFFMVVAVVYILYLLFLIVRACSELGHMPYVDLRLKFLTALTFVVLVISIVILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAQYKEGSESD", "length": 583, "header": "tr|A0AAA9TD35-1|A0AAA9TD35_BOVIN Isoform 1 of Transmembrane protein 181 OS=Bos taurus OX=9913 GN=TMEM181 PE=4 SV=1 CANONICAL=A0AAA9TD35-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35/entry#A0AAA9T9G2-1", "sequence": { "sequence": "MDAEYPAFEPPLCSELKHLCKRLQEAYRELKEDLTPFRDDRYYRLAPMRLYTLSKHHFVLVFVVFFVCFGLTVFVGIRGPKVIQTSAANFSLNNSKKLKPIQIFSKPLSTYNQQLWLTCVVELDQSKETSIQTTFTMTVKVDGVAQDGTTKFIHNKVHNRTRTLTCAEKCAEIIVAHLSYLNYTKYTVTVGFEHLKRPIKEMNFTWKTYDPAFSHLEIWFRFVFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSILLPLLLLYNDPFFPLSFLVNSWFPGMLDDLFQSVFLCALLLFWLCVYHGVRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGVKVFFMVVAVVYILYLLFLIVRACSELGHMPYVDLRLKFLTALTFVVLVISIVILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAQYKEGSESD", "length": 516, "header": "tr|A0AAA9T9G2-1|A0AAA9TD35_BOVIN Computationally mapped isoform of Transmembrane protein 181 OS=Bos taurus OX=9913 GN=TMEM181 PE=4 SV=1 CANONICAL=A0AAA9TD35-1" }, "locus": { "chromosome": "9", "start_pos": 95044015, "end_pos": 94983824, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114626.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114626.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093496.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093496.1" } ] } }, { "isoform_ac": "A0AAA9TD35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD35/entry#A0AAA9TD35-1", "sequence": { "sequence": "MQTPFRQPRAFLDSHGRSHAEMETLWKERVAELTRCPLRWAQGPCTPPPPRRGPSPRRAASAHVTRPRVALGESPGAGAPRAAVPPAPPAAAAVSAPSPPGAEGRAAAMEPLAPMRLYTLSKHHFVLVFVVFFVCFGLTVFVGIRGPKVIQTSAANFSLNNSKKLKPIQIFSKPLSTYNQQLWLTCVVELDQSKETSIQTTFTMTVKVDGVAQDGTTKFIHNKVHNRTRTLTCAEKCAEIIVAHLSYLNYTKYTVTVGFEHLKRPIKEMNFTWKTYDPAFSHLEIWFRFVFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSILLPLLLLYNDPFFPLSFLVNSWFPGMLDDLFQSVFLCALLLFWLCVYHGVRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGVKVFFMVVAVVYILYLLFLIVRACSELGHMPYVDLRLKFLTALTFVVLVISIVILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAQYKEGSESD", "length": 583, "header": "tr|A0AAA9TD35-1|A0AAA9TD35_BOVIN Isoform 1 of Transmembrane protein 181 OS=Bos taurus OX=9913 GN=TMEM181 PE=4 SV=1 CANONICAL=A0AAA9TD35-1" }, "locus": { "chromosome": "9", "start_pos": 95044015, "end_pos": 95001098, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126728.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126728.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094661.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094661.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 256, "start_aa": "Thr", "end_pos": 256, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr256", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:614300", "name": 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"url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836411" }, "gene_names": [ { "name": "MMP28", "type": "recommended", "evidence": [ { "id": "A0AAA9T9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ] }, { "name": "MMP28", "type": "synonym", "evidence": [ { "id": "XP_024836411", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836411" } ] } ], "protein_names": [ { "name": "Matrix metallopeptidase 28", "type": "synonym", "evidence": [ { "id": "A0AAA9T9K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2/entry#names_and_taxonomy" } ] }, { "name": "matrix metalloproteinase-28 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024836411", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836411" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MMP28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2", "locus": { "chromosome": "19", "start_pos": 14613457, "end_pos": 14587774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006086", "url": "https://www.ensembl.org/id/ENSBTAG00000006086" } ] } } ], "crossref": [ { "id": "A0AAA9T9K2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9K2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006086", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006086", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00094", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00094", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04278", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04278", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519276", "url": "https://www.ncbi.nlm.nih.gov/gene/519276", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519276", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519276", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYWHLDQ", "url": "https://omabrowser.org/oma/group/RYWHLDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BK30", "url": "https://www.orthodb.org/?gene=E1BK30", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10201:SF298", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10201:SF298", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00045", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00045", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00413", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01471", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01471", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836411", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836411", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK30", "url": "https://www.uniprot.org/uniprotkb/E1BK30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BK30-1", "url": "https://www.uniprot.org/uniprotkb/E1BK30-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARVGLLLRVLPLLLWGGLDAQRVGPELRREAEAFLEKYGYLSDQGPSRPSSTQFSNAIREFQWVSQLPISGVLDPPTLHQMTRPRCGVADTDSQMPWTERVSALFAGRWAKMRRKKRFARQGNKWYKRHLSYRLLNWPQHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLAFFQGDHNDGLSNAFDGPGGALAHAFLPRRGEAHFDRDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSAAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPQGGSVAIQLPGKLFTDFEAWDPLRLQGRRPETRGPKYCHSSFDAVTVDGQQRLYVFQGNQFWEVTADGNVSEPRPLRERWAGLPPHIEAAAVSLEDGDFYFFKGSRCWRFRGPKPVWGSPQLCRAGGLPRHPDAAFFFPPLRRLVLFKGTRYYVLAREGLQVEPYYPRGLRDWGGVPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQTTTSGRWATELPWMGCWHANSGGALF", "length": 517, "header": "tr|A0AAA9T9K2-1|A0AAA9T9K2_BOVIN Isoform 1 of Matrix metallopeptidase 28 OS=Bos taurus OX=9913 GN=MMP28 PE=3 SV=1 CANONICAL=A0AAA9T9K2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9K2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2/entry#A0AAA9T9K2-1", "sequence": { "sequence": "MAARVGLLLRVLPLLLWGGLDAQRVGPELRREAEAFLEKYGYLSDQGPSRPSSTQFSNAIREFQWVSQLPISGVLDPPTLHQMTRPRCGVADTDSQMPWTERVSALFAGRWAKMRRKKRFARQGNKWYKRHLSYRLLNWPQHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLAFFQGDHNDGLSNAFDGPGGALAHAFLPRRGEAHFDRDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSAAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPQGGSVAIQLPGKLFTDFEAWDPLRLQGRRPETRGPKYCHSSFDAVTVDGQQRLYVFQGNQFWEVTADGNVSEPRPLRERWAGLPPHIEAAAVSLEDGDFYFFKGSRCWRFRGPKPVWGSPQLCRAGGLPRHPDAAFFFPPLRRLVLFKGTRYYVLAREGLQVEPYYPRGLRDWGGVPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQTTTSGRWATELPWMGCWHANSGGALF", "length": 517, "header": "tr|A0AAA9T9K2-1|A0AAA9T9K2_BOVIN Isoform 1 of Matrix metallopeptidase 28 OS=Bos taurus OX=9913 GN=MMP28 PE=3 SV=1 CANONICAL=A0AAA9T9K2-1" }, "locus": { "chromosome": "19", "start_pos": 14612748, "end_pos": 14588018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090775.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090775.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093311.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093311.1" } ] } }, { "isoform_ac": "E1BK30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2/entry#E1BK30-1", "sequence": { "sequence": "MEENQAPGWSEAFLEKYGYLSDQGPSRPSSTQFSNAIREFQWVSQLPISGVLDPPTLHQMTRPRCGVADTDSQMPWTERVSALFAGRWAKMRRKKRFARQGNKWYKRHLSYRLLNWPQHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLAFFQGDHNDGLSNAFDGPGGALAHAFLPRRGEAHFDRDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSAAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPQGGSVAIQLPGKLFTDFEAWDPLRLQGRRPETRGPKYCHSSFDAVTVDGQQRLYVFQGNQFWEVTADGNVSEPRPLRERWAGLPPHIEAAAVSLEDGDFYFFKGSRCWRFRGPKPVWGSPQLCRAGGLPRHPDAAFFFPPLRRLVLFKGTRYYVLAREGLQVEPYYPRGLRDWGGVPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQTTTSGRWATELPWMGCWHANSGGALF", "length": 494, "header": "tr|E1BK30-1|E1BK30_BOVIN Computationally mapped isoform of Matrix metallopeptidase 28 OS=Bos taurus OX=9913 GN=MMP28 PE=3 SV=3 CANONICAL=A0AAA9T9K2-1" }, "locus": { "chromosome": "19", "start_pos": 14612748, "end_pos": 14597466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007997.7", "url": "https://www.ensembl.org/id/ENSBTAT00000007997.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007997.6", "url": "https://www.ensembl.org/id/ENSBTAP00000007997.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519276", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519276", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ATR1-1", "protein_name": "Matrix metallopeptidase 28", "gene_name": "MMP28", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAARVGLLLRTLPLLLWGGLDAQLAQRVGQELRREAEAFLEKYGYLNEQVPQSPTSSLRFSKAIREFQWVSQLPISGVLDPATLRQMMRPRCGVADTNSQAPGTERVSALFAGHQAKMRRKKRFARQGTKWYKQHLSYRLVNWPQHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLSNAFDGPGGALAHAFLPRRGEAHFDRDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSAAPRALMAPYYKRLGRDALLSWDDVLAVQNLYGKPQGGSVATQLPGKLFTDFEAWDPHRLQERLPETPGPKYCHSSFDAVTVDRQQRLYVFQGNQFWEVAADGNVSEPRPLQERWAGLPPHIEAAAVSLEEGDFYFFKGSRCWRFRGPKPVWGSPKLCRAGGLPRHPDAALFFPPLNRLILFKGARYYVLARGGLQVEPYYPRGLKDWGGVPEEVMGALPRPDGSIIFFRDDRYWRLDQNKLQATASGRWATELPWMGCWHANSGGALF", "length": 521 }, "evidence": [ { "id": "A0AAA9T9K2", "url": "https://omabrowser.org/oma/group/A0AAA9T9K2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2M312-1", "protein_name": "Matrix metalloproteinase-28 isoform X1", "gene_name": "Mmp28", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVPGVSLLLRALLLLLLLLWGCRDAQPARLGHPELRQEAEAFLEKYGYFSEQGSKAPASTQFRNAIREFQWVSQLPISGVLDQATLRQMTLPRCGVADTDSHAAWAKRISALFAGPGAKMRRKKRFARPGNKWYKQHLSYRLVNWPERLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLPRRGEAHFDRDERWSLSRRRGRNLFVVLAHEIGHTLGLAHSPAPRALMAPYYKKLGRDALLSWDDVLAVQSLYGKPLGRSVATQLPGKLFTDFEAWDPHNSRRIRPETRGPKYCHSSFDAITVDRQWRLYIFKGSYFWEVTADGNVSEPRPLQKRWPGLPPDIEAAAVSLEDGDFYFFKGSRCWRFQGTKSVWGHSQLCRGGRLPRHPDAALFFPPLRRLVLFKGSRYYVLARGGKQVEPYYPRSLRDWAGVPEEVSGALPRPDGSVVFFRDDHYWQLDQAKLRVTSSGRWATELSWMGCWNANSGGALF", "length": 523 }, "evidence": [ { "id": "A0AAA9T9K2", "url": "https://omabrowser.org/oma/group/A0AAA9T9K2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1AN12-1", "protein_name": "Matrix metallopeptidase 28", "gene_name": "MMP28", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGLRAALGLLPLLPLLLLAAVRGAAVRGERRRAELFLQKYGYLGAPQAGRLSPVEFTAALRDFQRVSHLRPSGVLDVPTLRQMGRPRCGMGDGESRPSAPRRRRSMQHGSKWHKRHLTYRMVNWPPYLPQHEVRLAVRAAFELWSNVSSLVFWEARDGPADIRLTFFHGDHNDGLNNAFDGPGGALAHAFFPRRGEAHFDSAERWSLHSGKGRNLFVVVAHEVGHTLGLEHSPTKSALMSPYYKKLGKDFVLNWDDILAIQNLYGKPSKGLAIQLPGRVFTHFQDWSGDLYGEEHQRRSLSTYYCHSFFDAITADTEHNLYVFKGSHFWVVSASGNASQPQPLHMRWPGLPAGIDACAYSPFSHSFYFFKGGRCWNYHHSTLMSGFPQKCSAHGLPRHPDTALYFQQLRRLVLFKGAKYFVLSEETLTLEPYYPRSLLDWDGVPPGTTGAVVHRDGFLYFFRDDRYWRFNQAKLQVVANGKWAAELPWMGCWDANGGHILF", "length": 501 }, "evidence": [ { "id": "A0AAA9T9K2", "url": "https://omabrowser.org/oma/group/A0AAA9T9K2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9H239-1", "protein_name": "Matrix metalloproteinase-28", "gene_name": "MMP28", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF", "length": 520 }, "evidence": [ { "id": "A0AAA9T9K2", "url": "https://omabrowser.org/oma/group/A0AAA9T9K2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" }, { "name": "collagen catabolic process", "id": "GO:0030574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030574", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9K2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9K2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": 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"end_pos": 76768025, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001343", "url": "https://www.ensembl.org/id/ENSBTAG00000001343" } ] } } ], "crossref": [ { "id": "A0AAA9T9M4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9M4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001343", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001343", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527397", "url": "https://www.ncbi.nlm.nih.gov/gene/527397", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527397", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527397", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR16206", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16206", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16206:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16206:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015320650", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015320650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1A9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA57", "url": "https://www.uniprot.org/uniprotkb/E1BA57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA57-1", "url": "https://www.uniprot.org/uniprotkb/E1BA57-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENRDVPPGPYRATKLWNEITTSFRVGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRTNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGKWGTENLDDNSQLFRFPTSSPLKTLPRRHPELRKNNIENFSKDKDSIFKLRNLSRRTPKKHGLHFSQENSEKMNCEIIEEDQENLAENREISQKDVEEVWRYVILIYLQTVLGVSSLEEVINPKQVIPQYIMYNMTNTSKHGVVILQDKSDDLPHWVLSAMKCLANWPRSNDMNNPTYIGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGYVTVSDRPRGIHKIQDDPQSSKILHLNNLNSFKSTECLLLSLLHKDKTKEESDTTERLQISDQGFQEKYDKKMQLVNFKNRRASANDIIGGSCYNLIGLSRMHVLSSNIKPRCYSLEGIVDLPGSSSKEVSSVFHQSVLNIEGQNNMQSLGSETKQESLMNLHSEEGIQKPFSVGYKRTSTLTTQDQEELYNGKCKPKQLCRSQSLLLRSSTRRNSYINMPVAEIIMKPNLEQGSTSVQTAMEGELGESSTTINKRLCKSTIELSENSLPPASSMLTGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPQLHDAMGTRSLMIHTFSRSVLRCAEEVDLDELLAARLVSFLMDHQQEILQVPSYLLAAVEKHLDYLRKGHVCIIKNPGDGVIAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNKSLPLKEKRRKIKQFQKEYPLIYQKRFPTSESEAALFGDKPTIKQPMLFLRKPKFRSLRY", "length": 815, "header": "tr|A0AAA9T9M4-1|A0AAA9T9M4_BOVIN Isoform 1 of DEP domain-containing protein 1A OS=Bos taurus OX=9913 GN=DEPDC1 PE=4 SV=1 CANONICAL=A0AAA9T9M4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9M4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4/entry#A0AAA9T9M4-1", "sequence": { "sequence": "MENRDVPPGPYRATKLWNEITTSFRVGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRTNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGKWGTENLDDNSQLFRFPTSSPLKTLPRRHPELRKNNIENFSKDKDSIFKLRNLSRRTPKKHGLHFSQENSEKMNCEIIEEDQENLAENREISQKDVEEVWRYVILIYLQTVLGVSSLEEVINPKQVIPQYIMYNMTNTSKHGVVILQDKSDDLPHWVLSAMKCLANWPRSNDMNNPTYIGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGYVTVSDRPRGIHKIQDDPQSSKILHLNNLNSFKSTECLLLSLLHKDKTKEESDTTERLQISDQGFQEKYDKKMQLVNFKNRRASANDIIGGSCYNLIGLSRMHVLSSNIKPRCYSLEGIVDLPGSSSKEVSSVFHQSVLNIEGQNNMQSLGSETKQESLMNLHSEEGIQKPFSVGYKRTSTLTTQDQEELYNGKCKPKQLCRSQSLLLRSSTRRNSYINMPVAEIIMKPNLEQGSTSVQTAMEGELGESSTTINKRLCKSTIELSENSLPPASSMLTGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPQLHDAMGTRSLMIHTFSRSVLRCAEEVDLDELLAARLVSFLMDHQQEILQVPSYLLAAVEKHLDYLRKGHVCIIKNPGDGVIAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNKSLPLKEKRRKIKQFQKEYPLIYQKRFPTSESEAALFGDKPTIKQPMLFLRKPKFRSLRY", "length": 815, "header": "tr|A0AAA9T9M4-1|A0AAA9T9M4_BOVIN Isoform 1 of DEP domain-containing protein 1A OS=Bos taurus OX=9913 GN=DEPDC1 PE=4 SV=1 CANONICAL=A0AAA9T9M4-1" }, "locus": { "chromosome": "3", "start_pos": 76788637, "end_pos": 76768286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112444.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112444.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094700.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094700.1" } ] } }, { "isoform_ac": "A0AAA9U1A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4/entry#A0AAA9U1A9-1", "sequence": { "sequence": "MENRDVPPGPYRATKLWNEITTSFRVGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRTNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGKWGTENLDDNSQLFRFPTSSPLKTLPRRHPELRKNNIENFSKDKDSIFKLRNLSRRTPKKHGLHFSQENSEKMNCEIIEEDQENLAENREISQKDVEEVWRYVILIYLQTVLGVSSLEEVINPKQVIPQYIMYNMTNTSKHGVVILQDKSDDLPHWVLSAMKCLANWPRSNDMNNPTYIGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILGLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPQLHDAMGTRSLMIHTFSRSVLRCAEEVDLDELLAARLVSFLMDHQQEILQVPSYLLAAVEKHLDYLRKGHIKNPGDGVIAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNKSLPLKEKRRKIKQFQKEYPLIYQKRFPTSESEAALFGDKPTIKQPMLFLRKPKFRSLRY", "length": 528, "header": "tr|A0AAA9U1A9-1|A0AAA9U1A9_BOVIN Computationally mapped isoform of DEP domain-containing protein 1B OS=Bos taurus OX=9913 GN=DEPDC1 PE=4 SV=2 CANONICAL=A0AAA9T9M4-1" }, "locus": { "chromosome": "3", "start_pos": 76788637, "end_pos": 76768286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122738.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122738.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103843.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103843.2" } ] } }, { "isoform_ac": "E1BA57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4/entry#E1BA57-1", "sequence": { "sequence": "MENRDVPPGPYRATKLWNEITTSFRVGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRTNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGKWGTENLDDNSQLFRFPTSSPLKTLPRRHPELRKNNIENFSKDKDSIFKLRNLSRRTPKKHGLHFSQENSEKMNCEIIEEDQENLAENREISQKDVEEVWRYVILIYLQTVLGVSSLEEVINPKQVIPQYIMYNMTNTSKHGVVILQDKSDDLPHWVLSAMKCLANWPRSNDMNNPTYIGFERDVFRTIADYFLDLPEPLLTFEYYELFVNILVVCGYVTVSDRPRGIHKIQDDPQSSKILHLNNLNSFKSTECLLLSLLHKDKTKEESDTTERLQISDQGFQEKYDKKMQLVNFKNRRASANDIIGGSCYNLIGLSRMHVLSSNIKPRCYSLEGIVDLPGSSSKEVSSVFHQSVLNIEGQNNMQSLGSETKQESLMNLHSEEGIQKPFSVGYKRTSTLTTQDQEELYNGKCKPKQLCRSQSLLLRSSTRRNSYINMPVAEIIMKPNLEQGSTSVQTAMEGELGESSTTINKRLCKSTIELSENSLPPASSMLTGTQSLLQPHLERVAIDALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPQLHDAMGTRSLGDSPSKNTGMGCHAFLQGIFPNPGVPHCGQILYHLSHQMIHTFSRSVLRCAEEVDLDELLAARLVSFLMDHQQEILQVPSYLLAAVEKHLDYLRKGHIKNPGDGVIAPLPTYSYCKQISAQEFDEQKVSTSQAAIAELLENIIKNKSLPLKEKRRKIKQFQKEYPLIYQKRFPTSESEAALFGDKPTIKQPMLFLRKPKFRSLRY", "length": 850, "header": "tr|E1BA57-1|E1BA57_BOVIN Computationally mapped isoform of DEP domain containing 1 OS=Bos taurus OX=9913 GN=DEPDC1 PE=4 SV=4 CANONICAL=A0AAA9T9M4-1" }, "locus": { "chromosome": "3", "start_pos": 76788637, "end_pos": 76768286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000040383.7", "url": "https://www.ensembl.org/id/ENSBTAT00000040383.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040158.6", "url": "https://www.ensembl.org/id/ENSBTAP00000040158.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527397", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527397", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9M4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 755, "end_pos": 757, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T9M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M4" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 108, "start_aa": "Phe", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 129, "end_pos": 131 }, { "start_pos": 142, "end_pos": 144 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 227, "end_pos": 229 }, { "start_pos": 755, "end_pos": 757 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9M9-1", "uniprot_ac": "A0AAA9T9M9", "uniprot_id": "A0AAA9T9M9_BOVIN", "mass": { "chemical_mass": 31558.0, "monoisotopic_mass": 31558.0 }, "refseq": { "ac": "NP_001377739", "name": "olfactory receptor family 51 subfamily AC member 4", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"resource": "Reactome", "description": "snRNP Assembly" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA05" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA05" } ], "pmid": "" }, { "name": "SMN complex", "id": "GO:0032797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032797", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA05", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA05" } ], "pmid": "" }, { "name": "Gemini of Cajal bodies", "id": "GO:0097504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097504", 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"ac": "NP_001376825", "name": "olfactory receptor family 4 subfamily F member 14G", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376825" }, "gene_names": [ { "name": "OR4F14G", "type": "recommended", "evidence": [ { "id": "A0AAA9TA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA47" } ] }, { "name": "OR4F14G", "type": "synonym", "evidence": [ { "id": "NP_001376825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376825" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9TA47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA47/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4F3/4F16/4F29", "type": "synonym", "evidence": [ { "id": "NP_001376825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376825" } ] }, { "name": "olfactory receptor family 4 subfamily F member 14G", "type": "synonym", "evidence": [ { "id": "NP_001376825", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376825" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TA89-1", "uniprot_ac": "A0AAA9TA89", "uniprot_id": "A0AAA9TA89_BOVIN", "mass": { "chemical_mass": 71314.0, "monoisotopic_mass": 71314.0 }, "refseq": { "ac": "XP_002691029", "name": "exonuclease 3'-5' domain-containing protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691029" }, "gene_names": [ { "name": "EXD2", "type": "recommended", "evidence": [ { "id": "A0AAA9TA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ] }, { "name": "EXD2", "type": "synonym", "evidence": [ { "id": "XP_002691029", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691029" } ] } ], "protein_names": [ { "name": "Exonuclease 3'-5' domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "A0AAA9TA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#names_and_taxonomy" } ] }, { "name": "3'-5' exoribonuclease EXD2", "type": "synonym", "evidence": [ { "id": "A0AAA9TA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#names_and_taxonomy" } ] }, { "name": "3.1.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9TA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#names_and_taxonomy" } ] }, { "name": "Exonuclease 3'-5' domain-like-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0AAA9TA89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#names_and_taxonomy" } ] }, { "name": "exonuclease 3'-5' domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "XP_002691029", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691029" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EXD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89", "locus": { "chromosome": "10", "start_pos": 81026336, "end_pos": 80972508, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010052", "url": "https://www.ensembl.org/id/ENSBTAG00000010052" } ] } } ], "crossref": [ { "id": "A0AAA9TA89", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TA89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010052", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010052", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06141", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06141", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539532", "url": "https://www.ncbi.nlm.nih.gov/gene/539532", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539532", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539532", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYYQTPK", "url": "https://omabrowser.org/oma/group/RYYQTPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BEQ0", "url": "https://www.orthodb.org/?gene=E1BEQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13620:SF104", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13620:SF104", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691029", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEQ0", "url": "https://www.uniprot.org/uniprotkb/E1BEQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BEQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKHLVALTVTTLLGVAVGGFVLWKGFQRRRSKSSPVTRRRLSQQQQQQQQQQVPGGRELPAPGEDQPHSIAPRASWEERILGAKVMTVSQEAEWDQIEPSLRSEIEDFPVLGIDCEWVNSEGKASPLSLLQMASPSGFCVLVRLPKLICGGKTLPKTLLDILADGTILKVGVGCSEDASKLLQDYGLVVKGCLDLRYLAMRQRNNLLSNGLSLKSLSETVLNFPLDKSLLLRCSNWDAENLTEDQVIYAARDAQISVALFLHLLGYPFSRNSTLEENDDHIVWRKILEKCQDVVDIPFRSKGLSRSGEEVNGEATESQQKTRNKKSKADGMMPGNQQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLQFEPAGRPESPGDYYLMVKENLCVVCGKKDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDIHLKQQLAREFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPAHRKEELLQGLREFYRTDRVTEEMLQEAASLETRISNENYIPHGLKVVQRHTQGGLRSLMQLESRWRQHFLDSMQPRHLPQQWSVDHNHQKLLRKYGEDLPIKLS", "length": 628, "header": "tr|A0AAA9TA89-1|A0AAA9TA89_BOVIN Isoform 1 of Exonuclease 3'-5' domain-containing protein 2 OS=Bos taurus OX=9913 GN=EXD2 PE=3 SV=1 CANONICAL=A0AAA9TA89-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TA89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#A0AAA9TA89-1", "sequence": { "sequence": "MSKHLVALTVTTLLGVAVGGFVLWKGFQRRRSKSSPVTRRRLSQQQQQQQQQQVPGGRELPAPGEDQPHSIAPRASWEERILGAKVMTVSQEAEWDQIEPSLRSEIEDFPVLGIDCEWVNSEGKASPLSLLQMASPSGFCVLVRLPKLICGGKTLPKTLLDILADGTILKVGVGCSEDASKLLQDYGLVVKGCLDLRYLAMRQRNNLLSNGLSLKSLSETVLNFPLDKSLLLRCSNWDAENLTEDQVIYAARDAQISVALFLHLLGYPFSRNSTLEENDDHIVWRKILEKCQDVVDIPFRSKGLSRSGEEVNGEATESQQKTRNKKSKADGMMPGNQQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLQFEPAGRPESPGDYYLMVKENLCVVCGKKDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDIHLKQQLAREFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPAHRKEELLQGLREFYRTDRVTEEMLQEAASLETRISNENYIPHGLKVVQRHTQGGLRSLMQLESRWRQHFLDSMQPRHLPQQWSVDHNHQKLLRKYGEDLPIKLS", "length": 628, "header": "tr|A0AAA9TA89-1|A0AAA9TA89_BOVIN Isoform 1 of Exonuclease 3'-5' domain-containing protein 2 OS=Bos taurus OX=9913 GN=EXD2 PE=3 SV=1 CANONICAL=A0AAA9TA89-1" }, "locus": { "chromosome": "10", "start_pos": 81025332, "end_pos": 80994910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095943.2", "url": "https://www.ensembl.org/id/ENSBTAT00000095943.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093536.1" } ] } }, { "isoform_ac": "E1BEQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89/entry#E1BEQ0-1", "sequence": { "sequence": "MSKHLVALTVTTLLGVAVGGFVLWKGFQRRRSKSSPVTRRRLSQQQQQQQQQQVPGGRELPAPGEDQPHSIAPRASWEERILGAKVMTVSQEAEWDQIEPSLRSEIEDFPVLGIDCEWVNSEGKASPLSLLQMASPSGFCVLVRLPKLICGGKTLPKTLLDILADGTILKVGVGCSEDASKLLQDYGLVVKGCLDLRYLAMRQRNNLLSNGLSLKSLSETVLNFPLDKSLLLRCSNWDAENLTEDQVIYAARDAQISVALFLHLLGYPFSRNSTLEENDDHIVWRKILEKCQDVVDIPFRSKGLSRSGEEVNGEATESQQKTRNKKSKADGMMPGNQQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLQFEPAGRPESPGDYYLMVKENLCVVCGKKDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDIHLKQQLAREFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPAHRKEELLQGLREFYRTDRVTEEMLQEAASLETRSVGIETQRFMFPVSNLPSRVLAC", "length": 580, "header": "tr|E1BEQ0-1|A0AAA9TA89_BOVIN Computationally mapped isoform of Exonuclease 3'-5' domain-containing protein 2 OS=Bos taurus OX=9913 GN=EXD2 PE=3 SV=3 CANONICAL=A0AAA9TA89-1" }, "locus": { "chromosome": "10", "start_pos": 81023272, "end_pos": 80994910, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013255.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013255.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013255.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013255.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539532", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539532", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A1J1-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "EXD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQVAKEVPVLQREVPQVFQSSPGPQIVGLVICFPSTAEKLKMSKHLVALTVTTLLGVAVGGFVLWKGIQRRRNKTSHVTRQQLPPPPQPKAPGRGELPAPEEDQPHSSAPRASWEERILKAKVVTVSQEEEWDQIEPLLRRELKDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCVLVRLPKLISGGKTLPKTLLDILADGTILKVGVGCSEDASKLLQDYGLIVKGCLDLRYLAMRHRNNLLSNGLSLKSLAETVLNFPLDKSLLLRCSNWDAENLTEDQVIYAARDAQISVALFLRLLGYPFSRNSTPEENNDRIGWRKVLEKCQDVVDVPFRSKGISRSGEEVHGEAAEAPQKPRNKKSKTDGAMPGTHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEDPFVVKLQFEPAGRPESPGDYYLMVKENLCVVCGKKDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYHDNHLKQQLAREFQAPIGSEEGLRLLEDPERRQVRSGARALLTAESLPAHRKEELLQALREFYHTHSVTEQMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPRHLPQQWSVDHNHQKLLRKYGEDLPIKLS", "length": 665 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z6W7-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "EXD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRQAAVPVALAALLGIAAGGLVLWKAAQRRRGRARSGSLREEAAGERPEGKASEAGGREALPLFAPPTLSWVERSLGADIVVVSERQEWDRVQPLLKKELEKWPVLGMDCEWVSVEGKANPVSLLQMASASGLCVLVRLPRLVASGQPVPKTLLDIMADDAVLKVGVGCWEDACKLLQDYSLPVKGSVDLRYLAMRQRKDLLHNCLSLKSLAEKVLNCPLDKSPHMRCSNWEAEELTQDQVLYAARDAQVSVALFLHLLGFACLPATSKGENSVSGWEKVLSKCQGLVDIPFKGRKSGSTGEDRSGEARSPHKGKNRRSVVNVHSSGSQQVRDPRRQKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRKKAQWYLDKGIGDLVSTDPFVVKLRFEPSGRPESDVDYYLMVKENLCVVCGKRESYIRKNIVPHEYRRHFPIQMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAEEFGAPIGSEEGVRLLEDPLRRQVRSGARALLNADSLPDPRKAELLQGIKDFFNVEAVTPEMLQEAAGLETRICNESYMPHGLKVVQCCAKGGLRSLMQLERRWRQHFLDSMQPKHLPEQWSVDHNHTKLIRKYGEDLQIQLS", "length": 621 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7FEI8-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "Exd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRQNLLALTVTTLLGVAMGGFVLWKGIQRKWSKTSRVMQPQLQPQPQQQQQPQPQQQQQPPQQEQQKQQVPGAREWPPPEDDQLPFGALRTPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGKTLPRTLLDILADGTILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNSVLCNGLSLKSLAETLLNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRNSYEEENNGQINWQKVLEKCRDMVDIPFRSKGLARLGEEINGEALESQQKPRNRKARTDGMVPGSNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIVTEEMLQEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS", "length": 648 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54YU4-1", "protein_name": "3'-5' exonuclease domain-containing protein", "gene_name": "exdl2A", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLKNKNILTNLLNNNKKSFIGTSIIFIAFYWVYNNYIKQIDNKDKDNTENNNENNENNNIVLNKTNDNSNIVKKVKFNNFFKLSNDIKIHVLSTPKECDLILNEFYQSLLLKMNDDKNSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPINTNTIIDGADILNQQQITTESNALLFPNCSEINNDGLDFIIGFDAEWSNFNSIDDSTTTTTTTSKYNHKVALIQLSSKNETFLIQVSQMEKIPTSLEQILTDPRLIKVGVAVSQDAATIFQTFSVVTKGCVDLVPIARLTNYEGNGLASLALNVMNVTLDKSNLIRCSHWENKDLTNDQIHYAAADAWVGREIFEIMYNTYKNSKTDPNEKDLIYTLCRPFINTSFKVKVEKSKNNNTGKPNPNKPIKENMLKKTVPDKRVLYDNCLMYSPDDVLLCSISKKKVEWYVSRQLADIIKEEPLSIKLKFQPHGEGHSGDDYYLAHKENICVVCGSTHKILRHSVVPHCYRQYLPEEIKSHSSHDVLLLCCDCHANMDKRAQIMRMMIAKQYNVPLDSENKVYITDNTLLKITKMALIVKNHFYQQQEQQQEEEKTIINEDGSCSSSTNKISNKKYKSNIPEYKLEEMKVEVANYIGKKEIDLKDLDQLIYLNPKQKNENYIPHEKQVMEKVLALGEKGIFEFIRSWRKNFIETVQPKFLSQHWSINKDILNNYKPKNQKPKQIQLQ", "length": 718 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VEG4-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "Exd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQQPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS", "length": 650 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NVH0-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "EXD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKFGEDLPIQLS", "length": 621 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VGN7-1", "protein_name": "Exonuclease 3'-5' domain-containing protein 2", "gene_name": "Exd2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTRESAVATKRNWAILAAGVGLVYVLVRHRHRLLCPLRRVWSFGSLVPQRRIEVINSVQDPTTQWVLNELKNHCQTFKVLGFDCEWITVGGSRRPVALLQLSSHRGLCALFRLCHMKQIPQDLRELLEDDSVIKVGVAPQEDAMKLSHDYGVGVASTLDLRFLCVMAGHKPEGLGKLSKTHLNYTLDKHWRLACSNWEAKTLEPKQLDYAANDALMAVAIYQKLCRDLQPKHFWQRRQLDDNSMHNKFEPFLDVDFTKGFTLNPSGSGVTRSKGSTQSKSNKWVPKKQPYRQIATRTKDFYDNCLLQAPDGELLCTIDRRKASWYLNQNLGTHISEEPFTVRLNFEPAGRAVGDVGRFYQTIKKNQCVVCGDRDAYIRKNVVPREYRKHFPLVMKSHTSDDVLLLCPTCHQLSNISDLRVRSKLAVQCEAPFKQEDGSVKYHDDPQLKRVQSAGKALLHHGAKIPAAKKAEMEKTLLDYYSDQTDITEDLLRQAASVEYRVENSDYCQHGERVVQQYRDHFGGLVELERLWRQHFLHTMQPRFLPELWNVNHNADRLEVRASEGRIDKADLMVAGLDAKIKET", "length": 583 }, "evidence": [ { "id": "A0AAA9TA89", "url": "https://omabrowser.org/oma/group/A0AAA9TA89/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "single-stranded DNA 3'-5' DNA exonuclease activity", "id": "GO:0008310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "3'-5'-RNA exonuclease activity", "id": "GO:0000175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000175", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "3'-5' exonuclease activity", "id": "GO:0008408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008408", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA89" } ], "pmid": "" }, { "name": "DNA double-strand break processing", "id": "GO:0000729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA89", "url": 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"A0AAA9TA96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA96/entry#A0AAA9TA96-1", "sequence": { "sequence": "MWELTVLLLLVPSSGQAATPEKPILSLHPPWTTIFKGEKVTLRCDGYHPLLLELRPISTLWYLGHLLLPSYKKSIEVHTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAAVFEGEPLVMRCRGWYDKTVYKLHYYHDGQPVRYFHSSANYTVPQARASDSGRYQCSGTMRIPVESAPMFSAKVAVTVQELFQEPVLRVIGRVEARGGAFGGVVLRCETRLHPQKRDTPLQFAFYKYSRPVRRYDWDAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGRGSPLDLASTTAPDPGNQPLSFRKPPVSRSVPSVPSVPNVTSAGPQFPAGGAPTAGPPACAPPTPLQQTAGALKPDVALLLREMQLLQGLLSRVVLELKETQPLPGHTVETPTSHSAVSQGTPETTTVES", "length": 417, "header": "tr|A0AAA9TA96-1|A0AAA9TA96_BOVIN Isoform 1 of Fc receptor like B OS=Bos taurus OX=9913 GN=FCRLB PE=4 SV=1 CANONICAL=A0AAA9TA96-1" }, "locus": { "chromosome": "3", "start_pos": 7889585, "end_pos": 7884635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127515.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127515.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094941.1", "url": 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{ "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 341, "start_aa": "Thr", "end_pos": 341, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:522702", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522702", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A8M3-1", "protein_name": "Fc receptor-like B", "gene_name": "Fcrlb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWTLTVLLLLVPGSGKAATLEKPVLSLHPPWTTIFKGERVTLRCDGYHPLLLELRPISTLWYLGHVLLPSHKKSIEVQAPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAAVFEGEPLVMRCRGWYDKVVYKLHYYHDGQAVRYFHSSTNYTVLQARASDSGHYQCSGTMRIPVESAPMFSSKVAVTVQELFQTPVLRTLSPQEARGRVVLRCETRLHPQKRDTPLQFAFYKYSRPVRRFDWGAEYTVPEPEVEELESYWCEAATTTRSVRKRSPWLQLPGRGSVLDLASTTAPAPQAAALAPGDKPLSFRKTPVSRSVPSVTSVPNSTFTGLQFPAGHVPTAGPHACVPLPTSTDLSREALQPKVDLLLREMQLLKGLLSRVVLGLKDPQALRELTETPETPNSLTVNPITPETTVVESQEDS", "length": 426 }, "evidence": [ { "id": "A0AAA9TA96", "url": "https://omabrowser.org/oma/group/A0AAA9TA96/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DRQ8-1", "protein_name": "Fc receptor-like B", "gene_name": "Fcrlb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/A0AAA9TAA6", "locus": {} } ], "crossref": [ { "id": "A0AAA9TAA6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAA6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004894", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004894", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01852", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01852", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LHKEICA", "url": "https://omabrowser.org/oma/group/LHKEICA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10903:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10903:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TAA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFF3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCF9", "url": "https://www.uniprot.org/uniprotkb/F1MCF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCF9-1", "url": "https://www.uniprot.org/uniprotkb/F1MCF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNIFTFPETAYMRQPAFLWFDRIMYCQDYISLVQFKDQKKLMEGLQRSRYGTMAEEHQGFEPSSSLRIILVGKTGSGRSATGNSILCQPVFESKLGAQAVTRKCQRATGMWNGRSIVVVDTPPIFEAEAQDQEVYENIGACYLLSVPGPHVLLLVTQLGRFTEQDVVAVTRVKEVFGAGAERYMVILFTHKEDLEGGSLDEYVANTDNLRLRRLVRECGRRYCAFNNRALGDEQREQLAQLMAVIEGLEREHQSAFLTNELFFDAQMLLQMGGGAHGEGQRRYLDKVRLQVAKQKQDLKEAERNSAFKALLRLKAWIVSHVKIFVLLVLCLLIFLAIVIILCTHQG", "length": 347, "header": "tr|A0AAA9TAA6-1|A0AAA9TAA6_BOVIN Isoform 1 of GTPase, IMAP family member 5 OS=Bos taurus OX=9913 GN=GIMAP5 PE=3 SV=2 CANONICAL=A0AAA9TAA6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6/entry#A0AAA9TAA6-1", "sequence": { "sequence": "MKNIFTFPETAYMRQPAFLWFDRIMYCQDYISLVQFKDQKKLMEGLQRSRYGTMAEEHQGFEPSSSLRIILVGKTGSGRSATGNSILCQPVFESKLGAQAVTRKCQRATGMWNGRSIVVVDTPPIFEAEAQDQEVYENIGACYLLSVPGPHVLLLVTQLGRFTEQDVVAVTRVKEVFGAGAERYMVILFTHKEDLEGGSLDEYVANTDNLRLRRLVRECGRRYCAFNNRALGDEQREQLAQLMAVIEGLEREHQSAFLTNELFFDAQMLLQMGGGAHGEGQRRYLDKVRLQVAKQKQDLKEAERNSAFKALLRLKAWIVSHVKIFVLLVLCLLIFLAIVIILCTHQG", "length": 347, "header": "tr|A0AAA9TAA6-1|A0AAA9TAA6_BOVIN Isoform 1 of GTPase, IMAP family member 5 OS=Bos taurus OX=9913 GN=GIMAP5 PE=3 SV=2 CANONICAL=A0AAA9TAA6-1" }, "locus": { "chromosome": "4", "start_pos": 113338367, "end_pos": 113329177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089969.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089969.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092902.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092902.2" } ] } }, { "isoform_ac": "A0AAA9TCS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6/entry#A0AAA9TCS7-1", "sequence": { "sequence": "MHPKFCNTLLFVGFRASFQPVGFSFVLTRDGNMKLMEGLQRSRYGTMAEEHQGFEPSSSLRIILVGKTGSGRSATGNSILCQPVFESKLGAQAVTRKCQRATGMWNGRSIVVVDTPPIFEAEAQDQEVYENIGACYLLSVPGPHVLLLVTQLGRFTEQDVVAVTRVKEVFGAGAERYMVILFTHKEDLEGGSLDEYVANTDNLRLRRLVRECGRRYCAFNNRALGDEQREQLAQLMAVIEGLEREHQSAFLTNELFFDAQMLLQMGGGAHGEGQRRYLDKVRLQVAKQKQDLKEAERNSAFKALLRLKAWIVSHVKIFVLLVLCLLIFLAIVIILCTHQG", "length": 340, "header": "tr|A0AAA9TCS7-1|A0AAA9TCS7_BOVIN Computationally mapped isoform of GTPase, IMAP family member 5 OS=Bos taurus OX=9913 GN=GIMAP5 PE=3 SV=2 CANONICAL=A0AAA9TAA6-1" }, "locus": { "chromosome": "4", "start_pos": 113338367, "end_pos": 113329904, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106588.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106588.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095867.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095867.2" } ] } }, { "isoform_ac": "A0AAA9TFF3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6/entry#A0AAA9TFF3-1", "sequence": { "sequence": "MEGLQRSRYGTMAEGGIEHQGFEPSSSLRIILVGKTGSGRSATGNSILCQPVFESKLGAQAVTRKCQRATGMWNGRSIVVVDTPPIFEAEAQDQEVYENIGACYLLSVPGPHVLLLVTQLGRFTEQDVVAVTRVKEVFGAGAERYMVILFTHKEDLEGGSLDEYVANTDNLRLRRLVRECGRRYCAFNNRALGDEQREQLAQLMAVIEGLEREHQSAFLTNELFFDAQMLLQMGGGAHGEGQRRYLDKVRLQVAKQKQDLKEAERNSAFKALLRLKAWIVSHVKIFVLLVLCLLIFLAIVIILCTHQG", "length": 308, "header": "tr|A0AAA9TFF3-1|A0AAA9TFF3_BOVIN Computationally mapped isoform of GTPase, IMAP family member 5 OS=Bos taurus OX=9913 GN=GIMAP5 PE=3 SV=1 CANONICAL=A0AAA9TAA6-1" }, "locus": { "chromosome": "4", "start_pos": 113338367, "end_pos": 113333614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128048.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128048.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095588.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095588.1" } ] } }, { "isoform_ac": "F1MCF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6/entry#F1MCF9-1", "sequence": { "sequence": "MEGLQRSRYGTMAEGGIEHQGFEPSSSLRIILVGKTGSGRSATGNSILCQPVFESKLGAQAVTRKCQRATGMWNGRSIVVVDTPPIFEAEAQDQEVYENIGACYLLSVPGPHVLLLVTQLGRFTEQDVVAVTRVKEVFGAGAERYMVILFTHKEDLEGGSLDEYVANTDNLRLRRLVRECGRRCSCRWGVAPMEKVRGATWTRYGCRLQSKSKT", "length": 214, "header": "tr|F1MCF9-1|A0AAA9TAA6_BOVIN Computationally mapped isoform of GTPase, IMAP family member 5 OS=Bos taurus OX=9913 GN=GIMAP5 PE=3 SV=4 CANONICAL=A0AAA9TAA6-1" }, "locus": { "chromosome": "4", "start_pos": 113338221, "end_pos": 113333614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031205.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031205.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031161.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031161.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q96F15-1", "protein_name": "GTPase IMAP family member 5", "gene_name": "GIMAP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIFHYI", "length": 307 }, "evidence": [ { "id": "A0AAA9TAA6", "url": "https://omabrowser.org/oma/group/A0AAA9TAA6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99MI6-1", "protein_name": "GTPase IMAP family member 3", "gene_name": "Gimap3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METLQNVVTGGKKGGCTSGSRPLRILLVGKSGCGKSATGNSLLRRPAFESRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDVMAVRMVKEVFGVGVMRHMIVLFTRKEDLAEKSLEEFVTHTDNRSLRSLVQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAETLLREGYSVHQEAYRCYLAKVRQEVEKQRWELEEQEGSWVLKVLPIGKKLEVLHSDFCWYLVLAILIFFVFFFLLFYV", "length": 301 }, "evidence": [ { "id": "A0AAA9TAA6", "url": "https://omabrowser.org/oma/group/A0AAA9TAA6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA6" }, { "id": "PS51720", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51720" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AIG1-type G", "eco_id": "ECO_0000259", "start_pos": 64, "end_pos": 267, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"A0AAA9TAC1_BOVIN", "mass": { "chemical_mass": 39829.0, "monoisotopic_mass": 39829.0 }, "refseq": {}, "gene_names": [ { "name": "ALX1", "type": "recommended", "evidence": [ { "id": "A0AAA9TAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" } ] } ], "protein_names": [ { "name": "ALX homeobox protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1/entry#names_and_taxonomy" } ] }, { "name": "Cartilage homeoprotein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1", "locus": { "chromosome": "5", "start_pos": 14939197, "end_pos": 14916523, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014977", "url": "https://www.ensembl.org/id/ENSBTAG00000014977" } ] } } ], "crossref": [ { "id": "A0AAA9TAC1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014977", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014977", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" 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"sequence": "MKAFLSHKLLCVTPLAYIHCRGDNVSECRGLVPAGICLKWSCLSNLGLDAPCPGGALEHVMETLDNESFYSKASAGKCVQAFGPLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRLSPVKGIPEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPEFERRSSSIAVLRMKAKEHAANISWAM", "length": 355, "header": "tr|A0AAA9TAC1-1|A0AAA9TAC1_BOVIN Isoform 1 of ALX homeobox protein 1 OS=Bos taurus OX=9913 GN=ALX1 PE=3 SV=1 CANONICAL=A0AAA9TAC1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1/entry#A0AAA9TAC1-1", "sequence": { "sequence": "MKAFLSHKLLCVTPLAYIHCRGDNVSECRGLVPAGICLKWSCLSNLGLDAPCPGGALEHVMETLDNESFYSKASAGKCVQAFGPLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRLSPVKGIPEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPEFERRSSSIAVLRMKAKEHAANISWAM", "length": 355, "header": "tr|A0AAA9TAC1-1|A0AAA9TAC1_BOVIN Isoform 1 of ALX homeobox protein 1 OS=Bos taurus OX=9913 GN=ALX1 PE=3 SV=1 CANONICAL=A0AAA9TAC1-1" }, "locus": { "chromosome": "5", "start_pos": 14938882, "end_pos": 14916529, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092929.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092929.1" } ] } }, { "isoform_ac": "E1BKK2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1/entry#E1BKK2-1", "sequence": { "sequence": "MPVHCRGDNVSECRGLVPAGICLKWSCLSNLGLDAPCPGGALEHVMETLDNESFYSKASAGKCVQAFGPLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNSLRLSPVKGIPEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPEFERRSSSIAVLRMKAKEHAANISWAM", "length": 340, "header": "tr|E1BKK2-1|E1BKK2_BOVIN Computationally mapped isoform of ALX homeobox protein 1 OS=Bos taurus OX=9913 GN=ALX1 PE=3 SV=3 CANONICAL=A0AAA9TAC1-1" }, "locus": { "chromosome": "5", "start_pos": 14938882, "end_pos": 14917132, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019938.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019938.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019938.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019938.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": 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"" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": 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"https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 219, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TAC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAC1" }, { "id": "PS50803", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50803" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OAR", "eco_id": "ECO_0000259", "start_pos": 335, "end_pos": 348, "start_aa": "Ser", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], 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"categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24408:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24408:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024834648", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAE7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAE7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNKSQGSVSFTDVTVDFTQEEWEQLDPSQRILYMDVMLENYSNLLSVEVWKADDQMETDPRNPDEQARPFVIFKDQTPTEERDNNLFGKTFNLSTDFVSLRQVPYKYDLYEKTLRYNSDLLTSNRNYIRKKADDCNGFGKALFYLKQEKTHPGVEYSEYNKSGKAFSHKEAIFKHQKIRNLVQPFICNYCDKAFSFKSLLISHKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTGEKPFECLECGKAFTHQSNLIVHQRAHMEKKPYECSECGKTFAQKFELTTHQRIHTGERPYECNECAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHMRTHTGEKPYECTECGKTFSQRSTLRLHLRIHTGEKPYECAECGKAFSRKSRLSVHQRVHTGDRP", 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"https://www.ncbi.nlm.nih.gov/protein/XP_002700433" }, "gene_names": [ { "name": "TXLNG", "type": "recommended", "evidence": [ { "id": "A0AAA9TAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ] }, { "name": "TXLNG", "type": "synonym", "evidence": [ { "id": "XP_002700433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700433" } ] } ], "protein_names": [ { "name": "Taxilin gamma", "type": "synonym", "evidence": [ { "id": "A0AAA9TAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9/entry#names_and_taxonomy" } ] }, { "name": "gamma-taxilin", "type": "synonym", "evidence": [ { "id": "XP_002700433", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700433" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TXLNG", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9", "locus": { "chromosome": "X", "start_pos": 126701246, "end_pos": 126743466, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001768", "url": "https://www.ensembl.org/id/ENSBTAG00000001768" } ] } } ], "crossref": [ { "id": "A0AAA9TAG9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001768", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001768", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515927", "url": "https://www.ncbi.nlm.nih.gov/gene/515927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026183", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026183", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PKELNTA", "url": "https://omabrowser.org/oma/group/PKELNTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G3X6A9", "url": "https://www.orthodb.org/?gene=G3X6A9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16127", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16127", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16127:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16127:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09728", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09728", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002700433", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002700433", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6A9", "url": "https://www.uniprot.org/uniprotkb/G3X6A9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X6A9-1", "url": "https://www.uniprot.org/uniprotkb/G3X6A9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATRVEEAARGRGGGAEEAVEAGRGGRRRSPRQKFVIGTMEEAGMCGLGVKADMLHNSQSNDILQHQDSHCGSTSNKHSLEEDARSDFITKGRSLVSPAYCTRESREEIPGREARTDPPDGQQDSECSRSKDKALGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIMKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDMHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEIQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIVWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSGRAAGGGPAPPEAQPCATSAPPEESGATWQSAARVIPEAGSLGAGPGIESVD", "length": 512, "header": "tr|A0AAA9TAG9-1|A0AAA9TAG9_BOVIN Isoform 1 of Taxilin gamma OS=Bos taurus OX=9913 GN=TXLNG PE=3 SV=1 CANONICAL=A0AAA9TAG9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9/entry#A0AAA9TAG9-1", "sequence": { "sequence": "MATRVEEAARGRGGGAEEAVEAGRGGRRRSPRQKFVIGTMEEAGMCGLGVKADMLHNSQSNDILQHQDSHCGSTSNKHSLEEDARSDFITKGRSLVSPAYCTRESREEIPGREARTDPPDGQQDSECSRSKDKALGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIMKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDMHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEIQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIVWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSGRAAGGGPAPPEAQPCATSAPPEESGATWQSAARVIPEAGSLGAGPGIESVD", "length": 512, "header": "tr|A0AAA9TAG9-1|A0AAA9TAG9_BOVIN Isoform 1 of Taxilin gamma OS=Bos taurus OX=9913 GN=TXLNG PE=3 SV=1 CANONICAL=A0AAA9TAG9-1" }, "locus": { "chromosome": "X", "start_pos": 126743225, "end_pos": 126702250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133349.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133349.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095695.1" } ] } }, { "isoform_ac": "G3X6A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9/entry#G3X6A9-1", "sequence": { "sequence": "MATRVEEAARGRGGGAEEAVEAGRGGRRRSPRQKLEESRNVQKQMKILQKKQAQIMKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDMHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEIQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIVWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSGRAAGGGPAPPEAQPCATSAPPEESGATWQSAARVIPEAGSLGAGPGIESVD", "length": 380, "header": "tr|G3X6A9-1|G3X6A9_BOVIN Computationally mapped isoform of Taxilin gamma OS=Bos taurus OX=9913 GN=TXLNG PE=3 SV=2 CANONICAL=A0AAA9TAG9-1" }, "locus": { "chromosome": "X", "start_pos": 126743225, "end_pos": 126702250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002316.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002316.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002316.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002316.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515927", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515927", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061HYT0-1", "protein_name": "Gamma-taxilin isoform X1", "gene_name": "Txlng", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATRIEEAARGRGGGTEEATEGEGGERRGSPRQKFEIETMEEAGICGLEVKEDMFCNSQANDILQHQDSSCGGTTKTHSLEGDEGSDFITKNMNLVSSAFRAQESREEIPGREARTGPPDGQQDSECSRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENLQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETMIWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAADGDLVSPAMQPCAALDSLKEMNTSRRALGMHLEARAKAKSVSERRSATQKPSSSGSAKGIESVD", "length": 528 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A0G2QC39-1", "protein_name": "Taxilin gamma", "gene_name": "Txlng", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATRLEEATRGRGGGTEEAIEGGPGGRGGRRRSPPEKFEIGTMEEARICELGVKADMVCKSQANDILQHQDSSCGGTTKKHSLEGDEGSDFVTNTRNLVSSVFCTQETREEIPGREARTGPPDGQQDSECSRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAADGDLVSPTTQPCAVLDSFKEMNTSRALGMPLEARAKTKSVSERSAAQKPSSSGSAAQGIESVD", "length": 530 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287BFL6-1", "protein_name": "Taxilin gamma", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATRVEEAARGRGGGVEEAIEAGRGGRRRSPRQKFVMGTMEEAGMCGLAVKADMLHNSQPNDILQHQDSHCGGTSNRHALEEDASSDFITKSRSLVSPAYCTQESREEIPGREARTDPPDGQQDSECSRSKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQMTLNEIQAQLEQHDLHNAKLRQENMELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRSKWENNNKALLQMAEEKTVRDKEYKAFQIKLDRLEKLCRALQTERNELNEKVEVLKGQVAGRAAGAGPAPPGAQPCAALPAPQESRTAWPVAPGVPPEAASPGAGPGIESVD", "length": 512 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1NI14-1", "protein_name": "Taxilin gamma", "gene_name": "TXLNG", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MATRGAEAARGGGSGGGGAAGRSRRHSQGRGGEEAVAGASGSPELVVGAMEEAGSQEMGMNNQDQLMNSRCNELSNTALQHTQPNCDGLEHTDMLEGTEYITKNRKLLGSTCCSQESREETPGREEARTDPPDGQQDPESEKHKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQVVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENIQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEAEEKHQREREFLLKEATESRHKCEQMKQQEAQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIVWRTKWENNNKALLQMAEEKTVRDKEYKGFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSLREADVDLAVQVLQSCTLNSHEELESPTDTEGGIQPSVESHAANRSEKTVSTSPVPGTESVD", "length": 535 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BHN1-1", "protein_name": "Gamma-taxilin", "gene_name": "Txlng", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATRLEEVTRGRGGGTEEASEGGRGGRRRSPPQKFEIGTMEEARICGLGVKADMVCNSQANDILQHQDPSCGGTTKKHSLEGDEGSDFITKNRNLVSSVFCTQEKREEIPGREARTGPPDGQQDSECSRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRNVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKAFQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAADGDLVSPATQPCAVLDSFKETSRRTLGMHLEARAKSVCEKSAAQKPSSSGSPAQGIESVD", "length": 524 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NUQ3-1", "protein_name": "Gamma-taxilin", "gene_name": "TXLNG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATRVEEAARGRGGGAEEATEAGRGGRRRSPRQKFEIGTMEEAGICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQRSAVQKPPSTGSAPAIESVD", "length": 528 }, "evidence": [ { "id": "A0AAA9TAG9", "url": "https://omabrowser.org/oma/group/A0AAA9TAG9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "syntaxin binding", "id": "GO:0019905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019905", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of bone mineralization", "id": "GO:0030500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030500", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" }, { "name": "regulation of cell cycle process", "id": "GO:0010564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010564", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], 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"MARARGQAPGSGGRRRPRRGSAGTGPRGESAGLLLLLLQVLPPGAAAGPGRRGTRGAGGVCWPSAAPAFPRDARLLLFLPPPPPPPPSSAPAASSSRMDAVPRGGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSGNQELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCGSASPRGFAPSPGSQQSGYGGSLGAGLGGYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLASASSMSLPAAAPTTSVFSFSPVHMISAVKQRSAFAPVLRPPSSPPQACPRTHGEGLPDQPFEDSDKFHSPARGLQGLAYS", "length": 695, "header": "tr|A0AAA9TAW8-1|A0AAA9TAW8_BOVIN Isoform 1 of Transcription factor COE4 OS=Bos taurus OX=9913 GN=EBF4 PE=3 SV=1 CANONICAL=A0AAA9TAW8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8/entry#A0A3Q1M4G4-1", "sequence": { 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"https://www.ensembl.org/id/ENSBTAT00000077139.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064697.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064697.2" } ] } }, { "isoform_ac": "A0A3Q1M8U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8/entry#A0A3Q1M8U0-1", "sequence": { "sequence": "MARARGQAPGSGGRRRPRRGSAGTGPRGESAGLLLLLLQVLPPGAAAGPGRRGTRGAGGVCWPSAAPAFPRDARLLLFLPPPPPPPPSSAPAASSSRMDAVPRGGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCGSASPRGFAPSPGSQQSGYGGSLGAGLGGYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLASASSMSLPAAAPTTSVFSFSPVHMISAVKQRSAFAPVLRPPSSPPQACPRTHGEGLPDQPFEDSDKFHSPARGLQGLAYS", "length": 673, "header": "tr|A0A3Q1M8U0-1|A0A3Q1M8U0_BOVIN Computationally mapped isoform of Transcription factor COE4 OS=Bos taurus OX=9913 GN=EBF4 PE=3 SV=2 CANONICAL=A0AAA9TAW8-1" }, "locus": { "chromosome": "13", "start_pos": 52479664, "end_pos": 52423098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070732.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070732.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066539.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066539.2" } ] } }, { "isoform_ac": "A0AAA9TAW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8/entry#A0AAA9TAW8-1", "sequence": { "sequence": "MARARGQAPGSGGRRRPRRGSAGTGPRGESAGLLLLLLQVLPPGAAAGPGRRGTRGAGGVCWPSAAPAFPRDARLLLFLPPPPPPPPSSAPAASSSRMDAVPRGGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSGNQELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCGSASPRGFAPSPGSQQSGYGGSLGAGLGGYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLASASSMSLPAAAPTTSVFSFSPVHMISAVKQRSAFAPVLRPPSSPPQACPRTHGEGLPDQPFEDSDKFHSPARGLQGLAYS", "length": 695, "header": "tr|A0AAA9TAW8-1|A0AAA9TAW8_BOVIN Isoform 1 of Transcription factor COE4 OS=Bos taurus OX=9913 GN=EBF4 PE=3 SV=1 CANONICAL=A0AAA9TAW8-1" }, "locus": { "chromosome": "13", "start_pos": 52479664, "end_pos": 52423098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089185.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089185.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095142.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095142.1" } ] } }, { "isoform_ac": "E1BFT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8/entry#E1BFT2-1", "sequence": { "sequence": "MQGAGILDASTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPSGNQELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCGSASPRGFAPSPGSQQSGYGGSLGAGLGGYGAPGVTGLGVPGSPSFLNGSTATSPFAIMPSSPPLASASSMSLPAAAPTTSVFSFSPVHMISAVKQRSAFAPVLRPPSSPPQACPRTHGEGLPDQPFEDSDKFHSPARGLQGLAYS", "length": 571, "header": "tr|E1BFT2-1|A0AAA9TAW8_BOVIN Computationally mapped isoform of Transcription factor COE4 OS=Bos taurus OX=9913 GN=EBF4 PE=3 SV=4 CANONICAL=A0AAA9TAW8-1" }, "locus": { "chromosome": "13", "start_pos": 52478790, "end_pos": 52423098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045103.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045103.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042518.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042518.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 538, "start_aa": "Thr", "end_pos": 538, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr538", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "T cell apoptotic process", "id": "GO:0070231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070231", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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"end_pos": 599 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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] }, { "id": "IPR036719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521876", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521876", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVYDVGE", "url": "https://omabrowser.org/oma/group/CVYDVGE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDD1", "url": "https://www.orthodb.org/?gene=F1MDD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18945", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18945", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02931", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02931", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02932", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02932", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-629594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-629594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179475", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29827", "url": "https://www.rhea-db.org/rhea/29827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD1", "url": "https://www.uniprot.org/uniprotkb/F1MDD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDD1-1", "url": "https://www.uniprot.org/uniprotkb/F1MDD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNWPHSCISFCWIYFAASRLRAVEPADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPPWARVVILKYMSRILFVYDVGESCLSPHQDRERDRLTKVYDKLPEPNLKTSRNKDPSRKKEVNKLLKNDLRYPGENLEDGDSYCARYRVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD", "length": 479, "header": "tr|A0AAA9TB23-1|A0AAA9TB23_BOVIN Isoform 1 of Neuronal acetylcholine receptor subunit alpha-9 OS=Bos taurus OX=9913 GN=CHRNA9 PE=3 SV=1 CANONICAL=A0AAA9TB23-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TB23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23/entry#A0AAA9TB23-1", "sequence": { "sequence": "MNWPHSCISFCWIYFAASRLRAVEPADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPPWARVVILKYMSRILFVYDVGESCLSPHQDRERDRLTKVYDKLPEPNLKTSRNKDPSRKKEVNKLLKNDLRYPGENLEDGDSYCARYRVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD", "length": 479, "header": "tr|A0AAA9TB23-1|A0AAA9TB23_BOVIN Isoform 1 of Neuronal acetylcholine receptor subunit alpha-9 OS=Bos taurus OX=9913 GN=CHRNA9 PE=3 SV=1 CANONICAL=A0AAA9TB23-1" }, "locus": { "chromosome": "6", "start_pos": 59337764, "end_pos": 59324388, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121708.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121708.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093243.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093243.1" } ] } }, { "isoform_ac": "F1MDD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23/entry#F1MDD1-1", "sequence": { "sequence": "MGRREWSVALAVEPADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPPWARVVILKYMSRILFVYDVGESCLSPHQDRERDRLTKVYDKLPEPNLKTSRNKDPSRKKEVNKLLKNDLRYPGENLEDGDSYCARYRVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD", "length": 468, "header": "tr|F1MDD1-1|F1MDD1_BOVIN Computationally mapped isoform of Neuronal acetylcholine receptor subunit alpha-9 OS=Bos taurus OX=9913 GN=CHRNA9 PE=3 SV=3 CANONICAL=A0AAA9TB23-1" }, "locus": { "chromosome": "6", "start_pos": 59337764, "end_pos": 59314371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039651.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039651.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039441.4", "url": "https://www.ensembl.org/id/ENSBTAP00000039441.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521876", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521876", "resource": "KEGG Pathway" }, { "id": "R-BTA-629594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-629594", "resource": "Reactome", "description": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "G3X8Z7-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "Chrna9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNRPHPCISFCWMYFAASGIKAVETANGKYAQKLFSDLFEDYSNALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVQGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQITKVYGKLPGSNLKASRNKDLSRKKELRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD", "length": 479 }, "evidence": [ { "id": "A0AAA9TB23", "url": "https://omabrowser.org/oma/group/A0AAA9TB23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3LPQ6-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "CHRNA9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNWPHSCISFCWIYFAASRLGAVDTADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDMYDGLDSIRIPSDLVWRPDIVLYNKADDDSSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDHQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYCCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRLLFVYDVGESCLGPRHDRERGRLSKVYGQLPEPDLKTARNKDLPRKKERNKLVKNDLRYPGETLQDADSYCARYTVLTRNIEYIAKCLKDHKATHSKGSEWKKVAKVIDRFFMWVFFIMVFVMTILIIARAD", "length": 479 }, "evidence": [ { "id": "A0AAA9TB23", "url": "https://omabrowser.org/oma/group/A0AAA9TB23/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P43144-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "Chrna9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRPHSCLSFCWMYFAASGIRAVETANGKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRNKDLSRKKEVRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD", "length": 479 }, "evidence": [ { "id": "A0AAA9TB23", "url": "https://omabrowser.org/oma/group/A0AAA9TB23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9PTS8-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "CHRNA9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRNNLSSFYVSLWLLFTATMLQAVESAKGKYAQMLFNELFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQSWYDAYLKWDKDKYDGLDSIRIPSNLVWRPDIVLYNKADDDFSEPVNTNVVLRYDGKITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIINSLDSGDLSDFVEDVEWEIHGMPAVKNVITYGCCSEPYPDVTFTLILKRKSSFYIFNLLLPCILISFLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAEIMPPSENVPLIGKYYIATMTMITASTALTIIIMNVHHCGSEAKPVPQWARVVILDYMSKIFFVYDVGENCTSPRREKEQEHRLEGGDMCRGGDGKSHLSSRNDDSDLKENLNGNWNKSFGVHGENVRENVNCCSCYKMLIKNIEYIANCVRDHKANRAKGIEWKKVAKVMDRFFMWIFFIMVFFMSVLIIGKAA", "length": 484 }, "evidence": [ { "id": "A0AAA9TB23", "url": "https://omabrowser.org/oma/group/A0AAA9TB23/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9UGM1-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "CHRNA9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD", "length": 479 }, "evidence": [ { "id": "A0AAA9TB23", "url": "https://omabrowser.org/oma/group/A0AAA9TB23/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "acetylcholine-gated monoatomic cation-selective channel activity", "id": "GO:0022848", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022848", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "serotonin-gated monoatomic cation channel activity", "id": "GO:0022850", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022850", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "excitatory extracellular ligand-gated monoatomic ion channel activity", "id": "GO:0005231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005231", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "acetylcholine-gated channel complex", "id": "GO:0005892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005892", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "transmembrane transporter complex", "id": "GO:1902495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902495", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "acetylcholine receptor signaling pathway", "id": "GO:0095500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0095500", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "membrane depolarization", "id": "GO:0051899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051899", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "response to auditory stimulus", "id": "GO:0010996", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010996", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB23" } ], "pmid": "" }, { "name": "regulation of membrane potential", "id": "GO:0042391", "url": 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"equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] }, { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] }, { "id": "29827", "name": "", "equation": "Mg(2+)(in) = Mg(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29827" } ] }, { "id": "34963", "name": "", "equation": "Na(+)(in) = Na(+)(out)", "summary": "", 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"uniprot_ac": "A0AAA9TB56", "uniprot_id": "A0AAA9TB56_BOVIN", "mass": { "chemical_mass": 26101.0, "monoisotopic_mass": 26101.0 }, "refseq": { "ac": "XP_015326927", "name": "retrotransposon Gag-like protein 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326927" }, "gene_names": [ { "name": "RTL6", "type": "recommended", "evidence": [ { "id": "A0AAA9TB56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56" } ] }, { "name": "RTL6", "type": "synonym", "evidence": [ { "id": "XP_015326927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326927" } ] } ], "protein_names": [ { "name": "Retrotransposon Gag like 6", "type": "synonym", "evidence": [ { "id": "A0AAA9TB56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56/entry#names_and_taxonomy" } ] }, { "name": "retrotransposon Gag-like protein 6", "type": "synonym", "evidence": [ { "id": "XP_015326927", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326927" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTL6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56", "locus": { "chromosome": "5", "start_pos": 115126902, "end_pos": 115133999, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000056562", "url": "https://www.ensembl.org/id/ENSBTAG00000056562" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012425", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012425", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786696", "url": "https://www.ncbi.nlm.nih.gov/gene/786696", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032549", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032549", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786696", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786696", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCASNRA", "url": "https://omabrowser.org/oma/group/TCASNRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B809", "url": "https://www.orthodb.org/?gene=E1B809", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PF16297", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16297", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015326927", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326927", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TB56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B809", "url": "https://www.uniprot.org/uniprotkb/E1B809", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B809-1", "url": "https://www.uniprot.org/uniprotkb/E1B809-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQPQTSKAETPASVASPSAPMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAMRERQTLCRQLAATGTAPCPVHPASSGTSPAPALPTRARNL", "length": 239, "header": "tr|A0AAA9TB56-1|A0AAA9TB56_BOVIN Isoform 1 of Retrotransposon Gag like 6 OS=Bos taurus OX=9913 GN=RTL6 PE=4 SV=1 CANONICAL=A0AAA9TB56-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TB56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56/entry#A0AAA9TB56-1", "sequence": { "sequence": "MVQPQTSKAETPASVASPSAPMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAMRERQTLCRQLAATGTAPCPVHPASSGTSPAPALPTRARNL", "length": 239, "header": "tr|A0AAA9TB56-1|A0AAA9TB56_BOVIN Isoform 1 of Retrotransposon Gag like 6 OS=Bos taurus OX=9913 GN=RTL6 PE=4 SV=1 CANONICAL=A0AAA9TB56-1" }, "locus": { "chromosome": "5", "start_pos": 115133130, "end_pos": 115132414, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125775.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125775.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103599.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103599.1" } ] } }, { "isoform_ac": "E1B809-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56/entry#E1B809-1", "sequence": { "sequence": "MDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAMRERQTLCRQLAATGTAPCPVHPASSGTSPAPALPTRARNL", "length": 218, "header": "tr|E1B809-1|E1B809_BOVIN Computationally mapped isoform of Retrotransposon Gag like 6 OS=Bos taurus OX=9913 GN=RTL6 PE=4 SV=3 CANONICAL=A0AAA9TB56-1" }, "locus": { "chromosome": "5", "start_pos": 115130169, "end_pos": 115129855, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016488.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016488.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040227.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040227.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 80, "start_aa": "Thr", "end_pos": 80, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr80", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:786696", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786696", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6G8M7-1", "protein_name": "Retrotransposon Gag like 6", "gene_name": "Rtl6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVQPQTSKTENPASAPGASAQMDDVVDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKPPLKHSRRAQIRKTSASNRAVRERERERQMLCRQLATAGTGPCPVHPASNGTSPAPALPTRGRNL", "length": 243 }, "evidence": [ { "id": "A0AAA9TB56", "url": "https://omabrowser.org/oma/group/A0AAA9TB56/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SJU6-1", "protein_name": "Retrotransposon Gag like 6", "gene_name": "RTL6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVQPQTSKAETPASAASTNAQMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAIASSGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAVRERQTLCRQLAATGAAPCPVHPASNGTSPAPALPTRARNL", "length": 239 }, "evidence": [ { "id": "A0AAA9TB56", "url": "https://omabrowser.org/oma/group/A0AAA9TB56/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q505G4-1", "protein_name": "Retrotransposon Gag-like protein 6", "gene_name": "Rtl6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVQPRTSKTESPASAPGASAQMDDVVDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHSRRAQIRKTSASNRAVRERERERQMLCRQLAAAGTGSCPVHPASNGTNPAPALPSRGRNL", "length": 243 }, "evidence": [ { "id": "A0AAA9TB56", "url": "https://omabrowser.org/oma/group/A0AAA9TB56/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ICC9-1", "protein_name": "Retrotransposon Gag-like protein 6", "gene_name": "RTL6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVQPQTSKAESPALAASPNAQMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISSITSNGTRPMTTPPTSLPEPFSGDPGRLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAVRERQMLCRQLASAGTGPCPVHPASNGTSPAPALPARARNL", "length": 239 }, "evidence": [ { "id": "A0AAA9TB56", "url": "https://omabrowser.org/oma/group/A0AAA9TB56/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TB56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB56" }, { "id": "PF16297", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16297" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4939", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 177, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 80 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 52, "end_pos": 54 }, { "start_pos": 89, "end_pos": 91 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TB60-1", "uniprot_ac": "A0AAA9TB60", "uniprot_id": "A0AAA9TB60_BOVIN", "mass": { "chemical_mass": 13862.0, "monoisotopic_mass": 13862.0 }, "refseq": { "ac": "XP_010814255", "name": "uncharacterized protein C17orf100 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814255" }, "gene_names": [ { "name": "C19H17orf100", "type": "recommended", "evidence": [ { "id": "A0AAA9TB60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60" } ] }, { "name": "C19H17orf100", "type": "synonym", "evidence": [ { "id": "XP_010814255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814255" } ] } ], "protein_names": [ { "name": "Chromosome 17 open reading frame 100", "type": "synonym", "evidence": [ { "id": "A0AAA9TB60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60/entry#names_and_taxonomy" } ] }, { "name": "uncharacterized protein C17orf100 homolog", "type": "synonym", "evidence": [ { "id": "XP_010814255", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814255" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "C19H17orf100", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60", "locus": {} } ], "crossref": [ { "id": "100138261", "url": "https://www.ncbi.nlm.nih.gov/gene/100138261", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:100138261", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138261", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSERRCE", "url": "https://omabrowser.org/oma/group/TSERRCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "XP_010814255", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814255", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TB60", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPLRGKPSPARAESICSEEKATVSVETSSHRVETSYRHVRTSSRQVETTYRSSEGPSVSPSGKRLPRVLEVSSQHVETASQLTETASRHVRASSLRVETSVHRMESPPRREKPAARQNVQKAR", "length": 125, "header": "tr|A0AAA9TB60-1|A0AAA9TB60_BOVIN Isoform 1 of Chromosome 17 open reading frame 100 OS=Bos taurus OX=9913 GN=C19H17orf100 PE=4 SV=1 CANONICAL=A0AAA9TB60-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TB60-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB60/entry#A0AAA9TB60-1", "sequence": { "sequence": "MASPLRGKPSPARAESICSEEKATVSVETSSHRVETSYRHVRTSSRQVETTYRSSEGPSVSPSGKRLPRVLEVSSQHVETASQLTETASRHVRASSLRVETSVHRMESPPRREKPAARQNVQKAR", "length": 125, "header": "tr|A0AAA9TB60-1|A0AAA9TB60_BOVIN Isoform 1 of Chromosome 17 open reading frame 100 OS=Bos taurus OX=9913 GN=C19H17orf100 PE=4 SV=1 CANONICAL=A0AAA9TB60-1" }, "locus": { "chromosome": "19", "start_pos": 25219615, "end_pos": 25219241, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093307.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093307.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138261", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138261", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A8MU93-1", "protein_name": 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"length": 1182, "header": "tr|A0AAA9TBD5-1|A0AAA9TBD5_BOVIN Isoform 1 of Cartilage intermediate layer protein OS=Bos taurus OX=9913 GN=CILP PE=4 SV=1 CANONICAL=A0AAA9TBD5-1" }, "locus": { "chromosome": "10", "start_pos": 12164589, "end_pos": 12151628, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095296.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095296.1" } ] } }, { "isoform_ac": "A0AAA9TVR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBD5/entry#A0AAA9TVR0-1", "sequence": { "sequence": "MAGAKACTFFFLVLQITSALGRQMMLTQSVRRVQPGKRTSGVFAKPANLLDRSLRRDTEHSLWSPWSPWSKCSAACGHPGVQTRTRTCLAESVSLCSEATEEGRHCMEQACSACDLTCPMGKANAECDACMCQDFVLYGAVSLPGGAPASGAAVYLLSKTPKLLTQTDSSGRFRVPGLCPDGKSILKITKTKFAPIHLTVPKTRLKAATIRAEFVRAETPYIVMSPETKARRAGQSVSLCCKATGKPKPDKYFWYHNNTLLDPSLYKHDSKLVLRNLRRDQAGEYFCKAQSDAGAAKSRIAQLTVIASDEIPCNPNPESYLIRLPHDCFQNATNSFYYDVGRCPVKTCAGKQDNGIRCRDAVEHCCGISKTEDREIQCSGYTLPTKVATECSCQRCTETRRIVRGRVSAADNGEPLRFGHVYMGNTRVSMTGYKGTFTLHVPQDTERLVLTFVDRMQKFVNTTKVLPFNKKGSAVFHEIKMLRRKEPITLEATETNIIPLGDMAGEDPVAELEIPSKSFYRQNGEPYMGKVKASVTFLDPRNISTATAAQSDLNFINDEGDTFPLRTYGMFSVDFRDEATSESLNVGKVKVHLDSTQVKMPEHVPMMKLWSLNPDTGLWEEEGDFKPESQRRNRREDRTFLVGNMEIRERRLFNLDVPESRRCFIKVRAYRSERFLPSEQIQGVVVSVINLEPRTGFSSNPRAWGRFDSVLTGPNGACLPAFCDDQSPDAYSAYVLASLAGEELEAVESSPKFNPNAIGVPQPYLNKLKYRRTDHEDPRVKKTAFQISMAKPRPNSPEEGNGPIYAFENLRECEDAPPSAAHFRFYQIEGDRYDYNTVPFNDDDPMGWTEDYLAWWPKPMEFRACYIKVKIVGPLEINVRSRNMGGTHRRTVGKLYGIRDVKSTRDRDQPNISSACLEFKCSGMLYDQDRVDRTLVKVIPQGSCQRASVNSMLHEYLVNHLPLAVNNNTSEYTMLAPLDPLGHNYGIYTVTDQDPRTAKEIALGRCFDGTSDGSSRVMKANVGVALTFNCVERQVGRQSAFQYLQNTPAQPSPASTVRGRVPSRRQRASQGSQRGGVASLRFPGAAQQPLSD", "length": 1092, "header": "tr|A0AAA9TVR0-1|A0AAA9TVR0_BOVIN Computationally mapped isoform of Cartilage intermediate layer protein OS=Bos taurus OX=9913 GN=CILP PE=4 SV=1 CANONICAL=A0AAA9TBD5-1" }, "locus": { "chromosome": "10", "start_pos": 12164589, "end_pos": 12151628, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100012.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100012.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101500.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336614", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336614", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": 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"glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1001, "end_pos": 1003 }, { "start_pos": 1057, "end_pos": 1059 }, { "start_pos": 1058, "end_pos": 1060 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 347, "end_pos": 349 }, { "start_pos": 421, "end_pos": 423 }, { "start_pos": 551, "end_pos": 553 }, { "start_pos": 632, "end_pos": 634 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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receptor family 6 subfamily C member 267", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377640" }, "gene_names": [ { "name": "OR6C267", "type": "recommended", "evidence": [ { "id": "A0AAA9TBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF8" } ] }, { "name": "OR6C267", "type": "synonym", "evidence": [ { "id": "NP_001377640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377640" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9TBF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily C member 267", "type": "synonym", "evidence": [ { "id": "NP_001377640", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377640" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377640" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBF8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C267", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF8", "locus": { "chromosome": "5", "start_pos": 57706904, "end_pos": 57705969, 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010800957", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800957", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBG5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRQAAGALLLTLLLLHGLLLAVTHGLRAYDGLSLPEDAETVTAGRAGWSYSDLSDDEDFLADEASGDGVGSGDLGSGDFQMVYFRALVNFTHSIDYSPQLEDAGSEEFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEVLHGVISSGSIASYVTSPQGFQFRRLGTVPQVPRACTEAEFACHRYNECVALEYRCDRRPDCRDMSDELDCEEPMPTLSSQPPPLGATPPPPAQPESLPSQQRPATPAPQAALPSPGRPVPCGPHEAACHSGHCIPKDYVCDGQEDCADGSDEADCGPTPPCEPNEFPCGNGHCALKLWRCDGDFDCEDHTDEADCPVKRPEDVCGPTKFRCVSTNTCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPQELIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLTIHDVKEADQGAYTCEAMNARGMVFGIPDGVLELIPQRGPCPDGHFYLEHSASCLPCFCFGVTNVCQSSRRFRDQIRLRFDQPNDFKGVNVTMPAQPGMPPVSSTQLQIDTTLQEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYKVRYELARGTLEPVQRPDVVLVGAGHRLLSRGHTSTQPGVPNQRQVQLSEEHWVHESGRPVQRAEMLQVLQSLEAVLIQTVYDHKMASVGLSDVAMDTTVTYATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDATKATATACRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAAGYEGNPIQPNGKCRPINQQIVRCDERGSTGSSGEACLCKNNVVGRLCNECVAGSFHLSARNPDGCLKCFCMGVSRQCTSSSWRRAQVLGASEEPTRFTLTNPTGTHNASEGISSPSPGELVFSSFHSLPPGPYFWSLPPHFLGDKVTSYGGELRFTVTQRPQPGSAPLPGQPLVVLQGNNIVLEHHTSQQPSSGQPSTFTVPFWEQAWQRPDGQPATREHLLMALADIDSLLIQASHTQRPAESRVSGISMDVAVPEDTGQDPAREVEQCACPPGYRGPSCQDCDAGYTRMPSGLYLGTCERCSCHGHTEVCEPETGACQECQHHTEGPRCEQCQPGYYGDAQRGTPHDCQPCPCHGAPAAGQATHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCRRSGGQLPEQIGCGCDPQGSVSNQCDPAGQCQCKAQVEGLTCSQCRPHHFHLSASNPDGCLPCFCMGVTQQCASSSYTRQLISTRFAPGDFQGFALVNPQRNSRLTGGFSVEPVPEGTQLSFGNFAHLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGAQGSPLSDPDVQITGNNIMLVASQPALQGPERKNYEVVFQEEFWRRPDGQPATREHLLMALADLDELLVRATFSSMPLAASISGVSLEVAQPGPSEGPRALEVEECRCPPGYVGSSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHHAAGEFCEQCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCAPGYVGNPNVPGGRCLPQADQAPLVVQVHPTRSVVPQGGPHSLRCQVSGSPPHYFYWSREDGRPLPSSTQQRHQGSELHFPSVQPSDAGVYICTCRNLHHANTSRAELLVTEAPGKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMDQGTATLHVQASATPSAPVVSIHPPQLTVQPGQMAEFRCSATGHPMPSLEWTGGPGGQLPQKAQVHRGILRLPAVEASDQGQYLCHAHSSAGQHVARAVLHVHGGNGPRVQVSPERTQVHEGRTVRLYCRAAGVPSATITWRKEGGSLPPQARAERTDIATLLIPAITAADAGFYLCVATSPAGTAQARIQVVVLPGATTPPVRIESSSPSVTEGQTLDLNCVVAGLAHSQITWYKRGGSLPPHAQVRGSRLRLPQVSPADSGEYVCRVENDSGPKEASIIVSVLHSRHPGPGYTPAPGGAPAPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSLLRLHQVSPADSGEYVCRVVLGSGPLETSVLVSIEASDAGTIPAPGPVPPVRIESSSPTVAEGQTLDLNCVVAGQAHAPVTWYKRGGTLPARHQVRGSRLYIFQASPADAGEYVCRASNGVEASITVTVTKTQGANFAYPPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQPHAQVTWHKRGGSLPARHQTHGSLLRLYQVSPADSGEYVCRVVGGSVPLESSVLVSIEPVDSVPALGVTPPVRIESSSSHVAEGQTLDLNCLVSGQPHAQVTWHKRGGSLPARHQVHGSRLRLPQMTPADSGEYVCRVVSGSGTQEASVLVTIQQRRGPTRYQNVVYPVRIESSSDSLANGRTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLIVTIQGSDSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAGQPQATITWYKRGGSLPARHQAHGSRLRLHQMSVADSGEYVCRANNNIDALEASIVVSVTPGTGGPSGPSGTMPIRIESSSSHVAEGQTLDLNCVVPGQAHAQVTWHRRGGSLPAHHQTHGSRLRLHRVSPADSGEYVCRVALGSGPLEASVLVTIEASGSGSVVVPAPGGAPPIRIETSSSHVAEGQTLDLKCVVPGQAHAQVTWHRRGGSLPARHQVHGPLLRLNHVSPADSGEYSCQVSSSSGTLEASVLVTIEASSPSPIPAPGLAQPIHIEASSSHVTEGQTVDLNCVVPGQAHAQVTWHKRGGSLPTRHQTHGSRLRLHHVSQSDSGEYVCRVVGGSGSEQEASFTITVPPSAGSSYRLRSPVISIDPPSSTVQQGQDASFKCLVHDGAAPISLEWKTRNQELEDNVRISPNGSIITIVGARPSNHGAYRCVASNAYGVAQSVVNLSVHGPPVVSVLPEGPVRVKLGKDVTLECVSSGEPRSSARWTRIGAPTHLEQRAHGLLDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKRVEVIVDTGAVAPGAPQVQVEEVELTVEAGHTATLRCSATGSPKPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNASSPAGHAEATVVLHVESPPYATTVPEHASVRAGEAVQLQCLAHGTPPLTFQWSRVGGHLPAGATARNELLLFEAAAPEDSGRYRCQVTNRVGLAEAFAQVLVRGPSGSLPATPAPAGSAPTVQVTPQLETKSIGASVEFHCVVPSDPGTQLRWVKEGGPLPPGHSVHDGVLRIQNLDQNCQGTYVCQAQGPWGQAQASAQLVVQALPSVLINIRTSVQSVVVGHAVEFECLALGDPKPQVTWSKVGGRLRPGIVQSGGIVRIARVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISTPPEVRVPAGSTAVFPCMVSGYPAPEITWSKLDGNLPPDSRLENHMLLLPSVQPQDAGTYVCTATNRQGKVKAFAQLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKQIPGSPANLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQGSLIVGSLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCQDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGHGYTCRCHLGRSGMRCEEGVTVTTPSLSGTDSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHHVSAERLNKDGSLQVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPAVQLPPATNVSAHFHGCVGEVSVNGKRLDLTYSFLGSQGVGQCYDSSPCERQPCRHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLHEPCLHGGTCQGTHCLCPPGFSGPRCQHSSAHGLVESDWHLEGSGGNDAPGQYGAYFYDNGFLALPGRIFSRSLPEVPETIELEVRTSTASGLLVWQGEETGQSGRGKDFISLGLQDGHLVFSYQLGSGEARLVSEDPINDGEWHRVTALREGQRGSIQVDGEELVSGQSPGPNVAVNTKGSIYVGGAPNVAVLTGGRFSSGITGCIKNLVLHSARPGGPPPQPVDMQHRAQAGANTRPCPS", "length": 4401, "header": "tr|A0AAA9TDR0-1|A0AAA9TDR0_BOVIN Isoform 1 of Basement membrane-specific heparan sulfate proteoglycan core protein OS=Bos taurus OX=9913 GN=HSPG2 PE=1 SV=1 CANONICAL=A0AAA9TDR0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBG5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0/entry#A0AAA9TBG5-1", "sequence": { "sequence": "MGRQAAGALLLTLLLLHGLLLAVTHGLRAYDGLSLPEDAETVTAGRAGWSYSDLSDDEDFLADEASGDGVGSGDLGSGDFQMVYFRALVNFTHSIDYSPQLEDAGSEEFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEVLHGVISSGSIASYVTSPQGFQFRRLGTVPQVPRACTEAEFACHRYNECVALEYRCDRRPDCRDMSDELDCEEPMPTLSSQPPPLGATPPPPAQPESLPSQQRPATPAPQAALPSPGRPVPCGPHEAACHSGHCIPKDYVCDGQEDCADGSDEADCGPTPPCEPNEFPCGNGHCALKLWRCDGDFDCEDHTDEADCPVKRPEDVCGPTKFRCVSTNTCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPQELIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLTIHDVKEADQGAYTCEAMNARGMVFGIPDGVLELIPQRGPCPDGHFYLEHSASCLPCFCFGVTNVCQSSRRFRDQIRLRFDQPNDFKGVNVTMPAQPGMPPVSSTQLQIDTTLQEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYKVRYELARGTLEPVQRPDVVLVGAGHRLLSRGHTSTQPGVPNQRQVQLSEEHWVHESGRPVQRAEMLQVLQSLEAVLIQTVYDHKMASVGLSDVAMDTTVTYATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDATKATATACRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAAGYEGNPIQPNGKCRPINQQIVRCDERGSTGSSGEACLCKNNVVGRLCNECVAGSFHLSARNPDGCLKCFCMGVSRQCTSSSWRRAQVLGASEEPTRFTLTNPTGTHNASEGISSPSPGELVFSSFHSLPPGPYFWSLPPHFLGDKVTSYGGELRFTVTQRPQPGSAPLPGQPLVVLQGNNIVLEHHTSQQPSSGQPSTFTVPFWEQAWQRPDGQPATREHLLMALADIDSLLIQASHTQRPAESRVSGISMDVAVPEDTGQDPAREVEQCACPPGYRGPSCQDCDAGYTRMPSGLYLGTCERCSCHGHTEVCEPETGACQECQHHTEGPRCEQCQPGYYGDAQRGTPHDCQPCPCHGAPAAGQATHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCRRSGGQLPEQIGCGCDPQGSVSNQCDPAGQCQCKAQVEGLTCSQCRPHHFHLSASNPDGCLPCFCMGVTQQCASSSYTRQLISTRFAPGDFQGFALVNPQRNSRLTGGFSVEPVPEGTQLSFGNFAHLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGAQGSPLSDPDVQITGNNIMLVASQPALQGPERKNYEVVFQEEFWRRPDGQPATREHLLMALADLDELLVRATFSSMPLAASISGVSLEVAQPGPSEGPRALEVEECRCPPGYVGSSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHHAAGEFCEQCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCAPGYVGNPNVPGGRCLPQADQAPLVVQVHPTRSVVPQGGPHSLRCQVSGSPPHYFYWSREDGRPLPSSTQQRHQGSELHFPSVQPSDAGVYICTCRNLHHANTSRAELLVTEAPGKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMDQGTATLHVQASATPSAPVVSIHPPQLTVQPGQMAEFRCSATGHPMPSLEWTGGPGGQLPQKAQVHRGILRLPAVEASDQGQYLCHAHSSAGQHVARAVLHVHGGNGPRVQVSPERTQVHEGRTVRLYCRAAGVPSATITWRKEGGSLPPQARAERTDIATLLIPAITAADAGFYLCVATSPAGTAQARIQVVVLPGATTPPVRIESSSPSVTEGQTLDLNCVVAGLAHSQITWYKRGGSLPPHAQVRGSRLRLPQVSPADSGEYVCRVENDSGPKEASIIVSVLHSRHPGPGYTPAPGGAPAPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSLLRLHQVSPADSGEYVCRVVLGSGPLETSVLVSIEASDAGTIPAPGPVPPVRIESSSPTVAEGQTLDLNCVVAGQAHAPVTWYKRGGTLPARHQVRGSRLYIFQASPADAGEYVCRASNGVEASITVTVTKTQGANFAYPPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQPHAQVTWHKRGGSLPARHQVHGSRLRLPQMTPADSGEYVCRVVSGSGTQEASVLVTIQQRRGPTRYQNVVYPVRIESSSDSLANGRTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLIVTIQGSDSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAGQPQATITWYKRGGSLPARHQAHGSRLRLHQMSVADSGEYVCRANNNIDALEASIVVSVTPGTGGPSGPSGTMPIRIESSSSHVAEGQTLDLNCVVPGQAHAQVTWHRRGGSLPAHHQTHGSRLRLHRVSPADSGEYVCRVALGSGPLEASVLVTIEASGSGSVVVPAPGGAPPIRIETSSSHVAEGQTLDLKCVVPGQAHAQVTWHRRGGSLPARHQVHGPLLRLNHVSPADSGEYSCQVSSSSGTLEASVLVTIEASSPSPIPAPGLAQPIHIEASSSHVTEGQTVDLNCVVPGQAHAQVTWHKRGGSLPTRHQTHGSRLRLHHVSQSDSGEYVCRVVGGSGSEQEASFTITVPPSAGSSYRLRSPVISIDPPSSTVQQGQDASFKCLVHDGAAPISLEWKTRNQELEDNVRISPNGSIITIVGARPSNHGAYRCVASNAYGVAQSVVNLSVHGPPVVSVLPEGPVRVKLGKDVTLECVSSGEPRSSARWTRIGAPTHLEQRAHGLLDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKRVEVIVDTGAVAPGAPQVQVEEVELTVEAGHTATLRCSATGSPKPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNASSPAGHAEATVVLHVESPPYATTVPEHASVRAGEAVQLQCLAHGTPPLTFQWSRVGGHLPAGATARNELLLFEAAAPEDSGRYRCQVTNRVGLAEAFAQVLVRGPSGSLPATPAPAGSAPTVQVTPQLETKSIGASVEFHCVVPSDPGTQLRWVKEGGPLPPGHSVHDGVLRIQNLDQNCQGTYVCQAQGPWGQAQASAQLVVQALPSVLINIRTSVQSVVVGHAVEFECLALGDPKPQVTWSKVGGRLRPGIVQSGGIVRIARVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISTPPEVRVPAGSTAVFPCMVSGYPAPEITWSKLDGNLPPDSRLENHMLLLPSVQPQDAGTYVCTATNRQGKVKAFAQLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKQIPGSPANLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQGSLIVGSLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCQDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGHGYTCRCHLGRSGMRCEEGVTVTTPSLSGTDSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHHVSAERLNKDGSLQVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPAVQLPPATNVSAHFHGCVGEVSVNGKRLDLTYSFLGSQGVGQCYDSSPCERQPCRHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLHEPCLHGGTCQGTHCLCPPGFSGPRCQHSSAHGLVESDWHLEGSGGNDAPGQYGAYFYDNGFLALPGRIFSRSLPEVPETIELEVRTSTASGLLVWQGEETGQSGRGKDFISLGLQDGHLVFSYQLGSGEARLVSEDPINDGEWHRVTALREGQRGSIQVDGEELVSGQSPGPNVAVNTKGSIYVGGAPNVAVLTGGRFSSGITGCIKNLVLHSARPGGPPPQPVDMQHRAQAGANTRPCPS", "length": 4305, "header": "tr|A0AAA9TBG5-1|A0AAA9TDR0_BOVIN Computationally mapped isoform of Basement membrane-specific heparan sulfate proteoglycan core protein OS=Bos taurus OX=9913 GN=HSPG2 PE=1 SV=1 CANONICAL=A0AAA9TDR0-1" }, "locus": { "chromosome": "2", "start_pos": 130976362, "end_pos": 130867595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088932.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088932.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094185.1" } ] } }, { "isoform_ac": "A0AAA9TCB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0/entry#A0AAA9TCB8-1", "sequence": { "sequence": "MERRWQEVTHGLRAYDGLSLPEDAETVTAGRAGWSYSDLSDDEDFLADEASGDGVGSGDLGSGDFQMVYFRALVNFTHSIDYSPQLEDAGSEEFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEVLHGVISSGSIASYVTSPQGFQFRRLGTVPQVPRACTEAEFACHRYNECVALEYRCDRRPDCRDMSDELDCEEPMPTLSSQPPPLGATPPPPAQPESLPSQQRPATPAPQAALPSPGRPVPCGPHEAACHSGHCIPKDYVCDGQEDCADGSDEADCGPTPPCEPNEFPCGNGHCALKLWRCDGDFDCEDHTDEADCPVKRPEDVCGPTKFRCVSTNTCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPQELIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLTIHDVKEADQGAYTCEAMNARGMVFGIPDGVLELIPQRGPCPDGHFYLEHSASCLPCFCFGVTNVCQSSRRFRDQIRLRFDQPNDFKGVNVTMPAQPGMPPVSSTQLQIDTTLQEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYKVRYELARGTLEPVQRPDVVLVGAGHRLLSRGHTSTQPGVPNQRQVQLSEEHWVHESGRPVQRAEMLQVLQSLEAVLIQTVYDHKMASVGLSDVAMDTTVTYATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDATKATATACRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAAGYEGNPIQPNGKCRPINQQIVRCDERGSTGSSGEACLCKNNVVGRLCNECVAGSFHLSARNPDGCLKCFCMGVSRQCTSSSWRRAQVLGASEEPTRFTLTNPTGTHNASEGISSPSPGELVFSSFHSLPPGPYFWSLPPHFLGDKVTSYGGELRFTVTQRPQPGSAPLPGQPLVVLQGNNIVLEHHTSQQPSSGQPSTFTVPFWEQAWQRPDGQPATREHLLMALADIDSLLIQASHTQRPAESRVSGISMDVAVPEDTGQDPAREVEQCACPPGYRGPSCQDCDAGYTRMPSGLYLGTCERCSCHGHTEVCEPETGACQECQHHTEGPRCEQCQPGYYGDAQRGTPHDCQPCPCHGAPAAGQATHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCRRSGGQLPEQIGCGCDPQGSVSNQCDPAGQCQCKAQVEGLTCSQCRPHHFHLSASNPDGCLPCFCMGVTQQCASSSYTRQLISTRFAPGDFQGFALVNPQRNSRLTGGFSVEPVPEGTQLSFGNFAHLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGAQGSPLSDPDVQITGNNIMLVASQPALQGPERKNYEVVFQEEFWRRPDGQPATREHLLMALADLDELLVRATFSSMPLAASISGVSLEVAQPGPSEGPRALEVEECRCPPGYVGSSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHHAAGEFCEQCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCAPGYVGNPNVPGGRCLPQADQAPLVVQVHPTRSVVPQGGPHSLRCQVSGSPPHYFYWSREDGRPLPSSTQQRHQGSELHFPSVQPSDAGVYICTCRNLHHANTSRAELLVTEAPGKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMDQGTATLHVQASATPSAPVVSIHPPQLTVQPGQMAEFRCSATGHPMPSLEWTGGPGGQLPQKAQVHRGILRLPAVEASDQGQYLCHAHSSAGQHVARAVLHVHGGNGPRVQVSPERTQVHEGRTVRLYCRAAGVPSATITWRKEGGSLPPQARAERTDIATLLIPAITAADAGFYLCVATSPAGTAQARIQVVVLPGATTPPVRIESSSPSVTEGQTLDLNCVVAGLAHSQITWYKRGGSLPPHAQVRGSRLRLPQVSPADSGEYVCRVENDSGPKEASIIVSVLHSRHPGPGYTPAPGGAPAPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSLLRLHQVSPADSGEYVCRVVLGSGPLETSVLVSIEASDAGTIPAPGPVPPVRIESSSPTVAEGQTLDLNCVVAGQAHAPVTWYKRGGTLPARHQVRGSRLYIFQASPADAGEYVCRASNGVEASITVTVTKTQGANFAYPPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQPHAQVTWHKRGGSLPARHQTHGSLLRLYQVSPADSGEYVCRVVGGSVPLESSVLVSIEPVDSVPALGVTPPVRIESSSSHVAEGQTLDLNCLVSGQPHAQVTWHKRGGSLPARHQVHGSRLRLPQMTPADSGEYVCRVVSGSGTQEASVLVTIQQRRGPTRYQNVVYPVRIESSSDSLANGRTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLIVTIQGSDSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAGQPQATITWYKRGGSLPARHQAHGSRLRLHQMSVADSGEYVCRANNNIDALEASIVVSVTPGTGGPSGPSGTMPIRIESSSSHVAEGQTLDLNCVVPGQAHAQVTWHRRGGSLPAHHQTHGSRLRLHRVSPADSGEYVCRVALGSGPLEASVLVTIEASGSGSVVVPAPGGAPPIRIETSSSHVAEGQTLDLKCVVPGQAHAQVTWHRRGGSLPARHQVHGPLLRLNHVSPADSGEYSCQVSSSSGTLEASVLVTIEASSPSPIPAPGLAQPIHIEASSSHVTEGQTVDLNCVVPGQAHAQVTWHKRGGSLPTRHQTHGSRLRLHHVSQSDSGEYVCRVVGGSGSEQEASFTITVPPSAGSSYRLRSPVISIDPPSSTVQQGQDASFKCLVHDGAAPISLEWKTRNQELEDNVRISPNGSIITIVGARPSNHGAYRCVASNAYGVAQSVVNLSVHGPPVVSVLPEGPVRVKLGKDVTLECVSSGEPRSSARWTRIGAPTHLEQRAHGLLDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKRVEVIVDTGAVAPGAPQVQVEEVELTVEAGHTATLRCSATGSPKPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNASSPAGHAEATVVLHVESPPYATTVPEHASVRAGEAVQLQCLAHGTPPLTFQWSRVGGHLPAGATARNELLLFEAAAPEDSGRYRCQVTNRVGLAEAFAQVLVRGPSGSLPATPAPAGSAPTVQVTPQLETKSIGASVEFHCVVPSDPGTQLRWVKEGGPLPPGHSVHDGVLRIQNLDQNCQGTYVCQAQGPWGQAQASAQLVVQALPSVLINIRTSVQSVVVGHAVEFECLALGDPKPQVTWSKVGGRLRPGIVQSGGIVRIARVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISTPPEVRVPAGSTAVFPCMVSGYPAPEITWSKLDGNLPPDSRLENHMLLLPSVQPQDAGTYVCTATNRQGKVKAFAQLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKQIPGSPANLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQGSLIVGSLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCQDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGHGYTCRCHLGRSGMRCEEGVTVTTPSLSGTDSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHHVSAERLNKDGSLQVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPAVQLPPATNVSAHFHGCVGEVSVNGKRLDLTYSFLGSQGVGQCYDSSPCERQPCRHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLHEPCLHGGTCQGTHCLCPPGFSGPRCQHSSAHGLVESDWHLEGSGGNDAPGQYGAYFYDNGFLALPGRIFSRSLPEVPETIELEVRTSTASGLLVWQGEETGQSGRGKDFISLGLQDGHLVFSYQLGSGEARLVSEDPINDGEWHRVTALREGQRGSIQVDGEELVSGQSPGPNVAVNTKGSIYVGGAPNVAVLTGGRFSSGITGCIKNLVLHSARPGGPPPQPVDMQHRAQAGANTRPCPS", "length": 4386, "header": "tr|A0AAA9TCB8-1|A0AAA9TCB8_BOVIN Computationally mapped isoform of Basement membrane-specific heparan sulfate proteoglycan core protein OS=Bos taurus OX=9913 GN=HSPG2 PE=1 SV=1 CANONICAL=A0AAA9TDR0-1" }, "locus": { "chromosome": "2", "start_pos": 130976362, "end_pos": 130870429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126357.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126357.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094383.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094383.1" } ] } }, { "isoform_ac": "A0AAA9TDR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0/entry#A0AAA9TDR0-1", "sequence": { "sequence": "MGRQAAGALLLTLLLLHGLLLAVTHGLRAYDGLSLPEDAETVTAGRAGWSYSDLSDDEDFLADEASGDGVGSGDLGSGDFQMVYFRALVNFTHSIDYSPQLEDAGSEEFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEVLHGVISSGSIASYVTSPQGFQFRRLGTVPQVPRACTEAEFACHRYNECVALEYRCDRRPDCRDMSDELDCEEPMPTLSSQPPPLGATPPPPAQPESLPSQQRPATPAPQAALPSPGRPVPCGPHEAACHSGHCIPKDYVCDGQEDCADGSDEADCGPTPPCEPNEFPCGNGHCALKLWRCDGDFDCEDHTDEADCPVKRPEDVCGPTKFRCVSTNTCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPQELIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLTIHDVKEADQGAYTCEAMNARGMVFGIPDGVLELIPQRGPCPDGHFYLEHSASCLPCFCFGVTNVCQSSRRFRDQIRLRFDQPNDFKGVNVTMPAQPGMPPVSSTQLQIDTTLQEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYKVRYELARGTLEPVQRPDVVLVGAGHRLLSRGHTSTQPGVPNQRQVQLSEEHWVHESGRPVQRAEMLQVLQSLEAVLIQTVYDHKMASVGLSDVAMDTTVTYATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDATKATATACRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAAGYEGNPIQPNGKCRPINQQIVRCDERGSTGSSGEACLCKNNVVGRLCNECVAGSFHLSARNPDGCLKCFCMGVSRQCTSSSWRRAQVLGASEEPTRFTLTNPTGTHNASEGISSPSPGELVFSSFHSLPPGPYFWSLPPHFLGDKVTSYGGELRFTVTQRPQPGSAPLPGQPLVVLQGNNIVLEHHTSQQPSSGQPSTFTVPFWEQAWQRPDGQPATREHLLMALADIDSLLIQASHTQRPAESRVSGISMDVAVPEDTGQDPAREVEQCACPPGYRGPSCQDCDAGYTRMPSGLYLGTCERCSCHGHTEVCEPETGACQECQHHTEGPRCEQCQPGYYGDAQRGTPHDCQPCPCHGAPAAGQATHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCRRSGGQLPEQIGCGCDPQGSVSNQCDPAGQCQCKAQVEGLTCSQCRPHHFHLSASNPDGCLPCFCMGVTQQCASSSYTRQLISTRFAPGDFQGFALVNPQRNSRLTGGFSVEPVPEGTQLSFGNFAHLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGAQGSPLSDPDVQITGNNIMLVASQPALQGPERKNYEVVFQEEFWRRPDGQPATREHLLMALADLDELLVRATFSSMPLAASISGVSLEVAQPGPSEGPRALEVEECRCPPGYVGSSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHHAAGEFCEQCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCAPGYVGNPNVPGGRCLPQADQAPLVVQVHPTRSVVPQGGPHSLRCQVSGSPPHYFYWSREDGRPLPSSTQQRHQGSELHFPSVQPSDAGVYICTCRNLHHANTSRAELLVTEAPGKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMDQGTATLHVQASATPSAPVVSIHPPQLTVQPGQMAEFRCSATGHPMPSLEWTGGPGGQLPQKAQVHRGILRLPAVEASDQGQYLCHAHSSAGQHVARAVLHVHGGNGPRVQVSPERTQVHEGRTVRLYCRAAGVPSATITWRKEGGSLPPQARAERTDIATLLIPAITAADAGFYLCVATSPAGTAQARIQVVVLPGATTPPVRIESSSPSVTEGQTLDLNCVVAGLAHSQITWYKRGGSLPPHAQVRGSRLRLPQVSPADSGEYVCRVENDSGPKEASIIVSVLHSRHPGPGYTPAPGGAPAPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSLLRLHQVSPADSGEYVCRVVLGSGPLETSVLVSIEASDAGTIPAPGPVPPVRIESSSPTVAEGQTLDLNCVVAGQAHAPVTWYKRGGTLPARHQVRGSRLYIFQASPADAGEYVCRASNGVEASITVTVTKTQGANFAYPPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQPHAQVTWHKRGGSLPARHQTHGSLLRLYQVSPADSGEYVCRVVGGSVPLESSVLVSIEPVDSVPALGVTPPVRIESSSSHVAEGQTLDLNCLVSGQPHAQVTWHKRGGSLPARHQVHGSRLRLPQMTPADSGEYVCRVVSGSGTQEASVLVTIQQRRGPTRYQNVVYPVRIESSSDSLANGRTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLIVTIQGSDSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAGQPQATITWYKRGGSLPARHQAHGSRLRLHQMSVADSGEYVCRANNNIDALEASIVVSVTPGTGGPSGPSGTMPIRIESSSSHVAEGQTLDLNCVVPGQAHAQVTWHRRGGSLPAHHQTHGSRLRLHRVSPADSGEYVCRVALGSGPLEASVLVTIEASGSGSVVVPAPGGAPPIRIETSSSHVAEGQTLDLKCVVPGQAHAQVTWHRRGGSLPARHQVHGPLLRLNHVSPADSGEYSCQVSSSSGTLEASVLVTIEASSPSPIPAPGLAQPIHIEASSSHVTEGQTVDLNCVVPGQAHAQVTWHKRGGSLPTRHQTHGSRLRLHHVSQSDSGEYVCRVVGGSGSEQEASFTITVPPSAGSSYRLRSPVISIDPPSSTVQQGQDASFKCLVHDGAAPISLEWKTRNQELEDNVRISPNGSIITIVGARPSNHGAYRCVASNAYGVAQSVVNLSVHGPPVVSVLPEGPVRVKLGKDVTLECVSSGEPRSSARWTRIGAPTHLEQRAHGLLDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKRVEVIVDTGAVAPGAPQVQVEEVELTVEAGHTATLRCSATGSPKPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNASSPAGHAEATVVLHVESPPYATTVPEHASVRAGEAVQLQCLAHGTPPLTFQWSRVGGHLPAGATARNELLLFEAAAPEDSGRYRCQVTNRVGLAEAFAQVLVRGPSGSLPATPAPAGSAPTVQVTPQLETKSIGASVEFHCVVPSDPGTQLRWVKEGGPLPPGHSVHDGVLRIQNLDQNCQGTYVCQAQGPWGQAQASAQLVVQALPSVLINIRTSVQSVVVGHAVEFECLALGDPKPQVTWSKVGGRLRPGIVQSGGIVRIARVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISTPPEVRVPAGSTAVFPCMVSGYPAPEITWSKLDGNLPPDSRLENHMLLLPSVQPQDAGTYVCTATNRQGKVKAFAQLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKQIPGSPANLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQGSLIVGSLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCQDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGHGYTCRCHLGRSGMRCEEGVTVTTPSLSGTDSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHHVSAERLNKDGSLQVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPAVQLPPATNVSAHFHGCVGEVSVNGKRLDLTYSFLGSQGVGQCYDSSPCERQPCRHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLHEPCLHGGTCQGTHCLCPPGFSGPRCQHSSAHGLVESDWHLEGSGGNDAPGQYGAYFYDNGFLALPGRIFSRSLPEVPETIELEVRTSTASGLLVWQGEETGQSGRGKDFISLGLQDGHLVFSYQLGSGEARLVSEDPINDGEWHRVTALREGQRGSIQVDGEELVSGQSPGPNVAVNTKGSIYVGGAPNVAVLTGGRFSSGITGCIKNLVLHSARPGGPPPQPVDMQHRAQAGANTRPCPS", "length": 4401, "header": "tr|A0AAA9TDR0-1|A0AAA9TDR0_BOVIN Isoform 1 of Basement membrane-specific heparan sulfate proteoglycan core protein OS=Bos taurus OX=9913 GN=HSPG2 PE=1 SV=1 CANONICAL=A0AAA9TDR0-1" }, "locus": { "chromosome": "2", "start_pos": 130976362, "end_pos": 130867595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128491.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128491.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096267.1" } ] } }, { "isoform_ac": "A0AAA9TIZ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0/entry#A0AAA9TIZ8-1", "sequence": { "sequence": "MGRQAAGALLLTLLLLHGLLLAVTHGLRAYDGLSLPEDAETVTAGRAGWSYSDLSDDEDFLADEASGDGVGSGDLGSGDFQMVYFRALVNFTHSIDYSPQLEDAGSEEFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEVLHGVISSGSIASYVTSPQGFQFRRLGTVPQVPRACTEAEFACHRYNECVALEYRCDRRPDCRDMSDELDCEEPMPTLSSQPPPLGATPPPPAQPESLPSQQRPATPAPQAALPSPGRPVPCGPHEAACHSGHCIPKDYVCDGQEDCADGSDEADCGPTPPCEPNEFPCGNGHCALKLWRCDGDFDCEDHTDEADCPVKRPEDVCGPTKFRCVSTNTCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPQELIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLTIHDVKEADQGAYTCEAMNARGMVFGIPDGVLELIPQRGPCPDGHFYLEHSASCLPCFCFGVTNVCQSSRRFRDQIRLRFDQPNDFKGVNVTMPAQPGMPPVSSTQLQIDTTLQEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYKVRYELARGTLEPVQRPDVVLVGAGHRLLSRGHTSTQPGVPNQRQVQLSEEHWVHESGRPVQRAEMLQVLQSLEAVLIQTVYDHKMASVGLSDVAMDTTVTYATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDATKATATACRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAAGYEGNPIQPNGKCRPINQQIVRCDERGSTGSSGEACLCKNNVVGRLCNECVAGSFHLSARNPDGCLKCFCMGVSRQCTSSSWRRAQVLGASEEPTRFTLTNPTGTHNASEGISSPSPGELVFSSFHSLPPGPYFWSLPPHFLGDKVTSYGGELRFTVTQRPQPGSAPLPGQPLVVLQGNNIVLEHHTSQQPSSGQPSTFTVPFWEQAWQRPDGQPATREHLLMALADIDSLLIQASHTQRPAESRVSGISMDVAVPEDTGQDPAREVEQCACPPGYRGPSCQDCDAGYTRMPSGLYLGTCERCSCHGHTEVCEPETGACQECQHHTEGPRCEQCQPGYYGDAQRGTPHDCQPCPCHGAPAAGQATHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCRRSGGQLPEQIGCGCDPQGSVSNQCDPAGQCQCKAQVEGLTCSQCRPHHFHLSASNPDGCLPCFCMGVTQQCASSSYTRQLISTRFAPGDFQGFALVNPQRNSRLTGGFSVEPVPEGTQLSFGNFAHLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGAQGSPLSDPDVQITGNNIMLVASQPALQGPERKNYEVVFQEEFWRRPDGQPATREHLLMALADLDELLVRATFSSMPLAASISGVSLEVAQPGPSEGPRALEVEECRCPPGYVGSSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHHAAGEFCEQCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCAPGYVGNPNVPGGRCLPQADQAPLVVQVHPTRSVVPQGGPHSLRCQVSGSPPHYFYWSREDGRPLPSSTQQRHQGSELHFPSVQPSDAGVYICTCRNLHHANTSRAELLVTEAPGKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPSRAMDFNGILTIRNVQPSDAGTYVCTGSNMFAMDQGTATLHVQASATPSAPVVSIHPPQLTVQPGQMAEFRCSATGHPMPSLEWTGGPGGQLPQKAQVHRGILRLPAVEASDQGQYLCHAHSSAGQHVARAVLHVHGGNGPRVQVSPERTQVHEGRTVRLYCRAAGVPSATITWRKEGGSLPPQARAERTDIATLLIPAITAADAGFYLCVATSPAGTAQARIQVVVLPGATTPPVRIESSSPSVTEGQTLDLNCVVAGLAHSQITWYKRGGSLPPHAQVRGSRLRLPQVSPADSGEYVCRVENDSGPKEASIIVSVLHSRHPGPGYTPAPGGAPAPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGEYVCRASNGVEASITVTVTKTQGANFAYPPGGTQPVRIEPSSSHVAEGQTLDLNCVVPGQPHAQVTWHKRGGSLPARHQTHGSLLRLYQVSPADSGEYVCRVVGGSVPLESSVLVSIEPVDSVPALGVTPPVRIESSSSHVAEGQTLDLNCLVSGQPHAQVTWHKRGGSLPARHQVHGSRLRLPQMTPADSGEYVCRVVSGSGTQEASVLVTIQQRRGPTRYQNVVYPVRIESSSDSLANGRTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSQETSLIVTIQGSDSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAGQPQATITWYKRGGSLPARHQAHGSRLRLHQMSVADSGEYVCRANNNIDALEASIVVSVTPGTGGPSGPSGTMPIRIESSSSHVAEGQTLDLNCVVPGQAHAQVTWHRRGGSLPAHHQTHGSRLRLHRVSPADSGEYVCRVALGSGPLEASVLVTIEASGSGSVVVPAPGGAPPIRIETSSSHVAEGQTLDLKCVVPGQAHAQVTWHRRGGSLPARHQVHGPLLRLNHVSPADSGEYSCQVSSSSGTLEASVLVTIEASSPSPIPAPGLAQPIHIEASSSHVTEGQTVDLNCVVPGQAHAQVTWHKRGGSLPTRHQTHGSRLRLHHVSQSDSGEYVCRVVGGSGSEQEASFTITVPPSAGSSYRLRSPVISIDPPSSTVQQGQDASFKCLVHDGAAPISLEWKTRNQELEDNVRISPNGSIITIVGARPSNHGAYRCVASNAYGVAQSVVNLSVHGPPVVSVLPEGPVRVKLGKDVTLECVSSGEPRSSARWTRIGAPTHLEQRAHGLLDSHTVLQISSAKPSDAGTYVCLAQNALGTAQKRVEVIVDTGAVAPGAPQVQVEEVELTVEAGHTATLRCSATGSPKPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNASSPAGHAEATVVLHVESPPYATTVPEHASVRAGEAVQLQCLAHGTPPLTFQWSRVGGHLPAGATARNELLLFEAAAPEDSGRYRCQVTNRVGLAEAFAQVLVRGPSGSLPATPAPAGSAPTVQVTPQLETKSIGASVEFHCVVPSDPGTQLRWVKEGGPLPPGHSVHDGVLRIQNLDQNCQGTYVCQAQGPWGQAQASAQLVVQALPSVLINIRTSVQSVVVGHAVEFECLALGDPKPQVTWSKVGGRLRPGIVQSGGIVRIARVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISTPPEVRVPAGSTAVFPCMVSGYPAPEITWSKLDGNLPPDSRLENHMLLLPSVQPQDAGTYVCTATNRQGKVKAFAQLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKQIPGSPANLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQGSLIVGSLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCQDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGHGYTCRCHLGRSGMRCEEGVTVTTPSLSGTDSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHHVSAERLNKDGSLQVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPAVQLPPATNVSAHFHGCVGEVSVNGKRLDLTYSFLGSQGVGQCYDSSPCERQPCRHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLHEPCLHGGTCQGTHCLCPPGFSGPRCQHSSAHGLVESDWHLEGSGGNDAPGQYGAYFYDNGFLALPGRIFSRSLPEVPETIELEVRTSTASGLLVWQGEETGQSGRGKDFISLGLQDGHLVFSYQLGSGEARLVSEDPINDGEWHRVTALREGQRGSIQVDGEELVSGQSPGPNVAVNTKGSIYVGGAPNVAVLTGGRFSSGITGCIKNLVLHSARPGGPPPQPVDMQHRAQAGANTRPCPS", "length": 4303, "header": "tr|A0AAA9TIZ8-1|A0AAA9TIZ8_BOVIN Computationally mapped isoform of Basement membrane-specific heparan sulfate proteoglycan core protein OS=Bos taurus OX=9913 GN=HSPG2 PE=1 SV=1 CANONICAL=A0AAA9TDR0-1" }, "locus": { "chromosome": "2", "start_pos": 130976362, "end_pos": 130867595, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105787.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105787.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096217.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1864, "start_aa": "Thr", "end_pos": 1864, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1864", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 252, "start_aa": "Thr", "end_pos": 252, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr252", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2725, "start_aa": "Thr", "end_pos": 2725, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2725", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 323, "start_aa": "Thr", "end_pos": 323, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr323", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3402, "start_aa": "Thr", "end_pos": 3402, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3402", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:444872", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:444872", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi lumen", "id": "GO:0005796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005796", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDR0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1757, "end_pos": 1759, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2121, "end_pos": 2123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3083, "end_pos": 3085, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3116, "end_pos": 3118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3289, "end_pos": 3291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3790, "end_pos": 3792, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3846, "end_pos": 3848, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4078, "end_pos": 4080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 964, "end_pos": 966, "annotation": "n_glycosylation_sequon" } ], 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TBT0-1", "uniprot_ac": "A0AAA9TBT0", "uniprot_id": "A0AAA9TBT0_BOVIN", "mass": { "chemical_mass": 40524.0, "monoisotopic_mass": 40524.0 }, "refseq": {}, "gene_names": [ { "name": "ADAL", "type": "recommended", "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0" } ] } ], "protein_names": [ { "name": "N6-Methyl-AMP deaminase", "type": "recommended", "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#names_and_taxonomy" } ] }, { "name": "Adenosine deaminase-like protein", "type": "synonym", "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#names_and_taxonomy" } ] }, { "name": "N6,N6-dimethyl-AMP deaminase", "type": "synonym", "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#names_and_taxonomy" } ] }, { "name": "N6-isopentenyl-AMP deaminase", "type": "synonym", "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP). 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[ "Protein" ] } ], "sequence": { "sequence": "MMEAEEQPWKTTFYSKLPKVELHAHLNGSISSSTIRKLIAKKPDLKIHDQMTMIDKGEKRTLEECLQMFQIIHLLTTTPEDVLMVTKDVIKEFADDGVKYLELRSTPRGEDATDVLFVSFPGMTKKTYVESILEGIKQSKEENVDIDVRYLISIDRRGGSSAAKEAVKLAEEFFLSAEDTVLGLDLSGDPSAGQAKDFLEPLLEAKKSGLKLALHLSEIPNQKTETQVLLNLFPDRIGHGTFLSSSEEGSPDLVDFVRQHQIPLELCLTSNVKSQTVPAYDQHHFGFWYSVAHPAVICTDDKGVFATRLSQEYQLVAETFHLTQSQVWDLSYESISYIFASDSTKADLRKKWSHLKPHF", "length": 359, "header": "tr|A0AAA9TBT0-1|A0AAA9TBT0_BOVIN Isoform 1 of N6-Methyl-AMP deaminase OS=Bos taurus OX=9913 GN=ADAL PE=3 SV=2 CANONICAL=A0AAA9TBT0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#A0AAA9TBT0-1", "sequence": { "sequence": "MMEAEEQPWKTTFYSKLPKVELHAHLNGSISSSTIRKLIAKKPDLKIHDQMTMIDKGEKRTLEECLQMFQIIHLLTTTPEDVLMVTKDVIKEFADDGVKYLELRSTPRGEDATDVLFVSFPGMTKKTYVESILEGIKQSKEENVDIDVRYLISIDRRGGSSAAKEAVKLAEEFFLSAEDTVLGLDLSGDPSAGQAKDFLEPLLEAKKSGLKLALHLSEIPNQKTETQVLLNLFPDRIGHGTFLSSSEEGSPDLVDFVRQHQIPLELCLTSNVKSQTVPAYDQHHFGFWYSVAHPAVICTDDKGVFATRLSQEYQLVAETFHLTQSQVWDLSYESISYIFASDSTKADLRKKWSHLKPHF", "length": 359, "header": "tr|A0AAA9TBT0-1|A0AAA9TBT0_BOVIN Isoform 1 of N6-Methyl-AMP deaminase OS=Bos taurus OX=9913 GN=ADAL PE=3 SV=2 CANONICAL=A0AAA9TBT0-1" }, "locus": { "chromosome": "21", "start_pos": 55108731, "end_pos": 55093357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128494.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128494.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096172.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096172.2" } ] } }, { "isoform_ac": "F1N1T1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0/entry#F1N1T1-1", "sequence": { "sequence": "MMEAEEQPWKTTFYSKLPKVELHAHLNGSISSSTIRKLIAKKPDLKIHDQMTMIDKGEKRTLEECLQMFQIIHLLTTTPEDVLMVTKDVIKEFADDGVKYLELRSTPRGEDATGMTKKTYVESILEGIKQSKEENVDIDVRYLISIDRRGGSSAAKEAVKLAEEFFLSAEDTVLGLDLSGDPSIPNQKTETQVLLNLFPDRIGHGTFLSSSEEGSPDLVDFVRQHQIPLELCLTSNVKSQTVPAYDQHHFGFWYSVAHPAVICTDDKGVFATRLSQEYQLVAETFHLTQSQVWDLSYESISYIFASDSTKADLRKKWSHLKPHF", "length": 324, "header": "tr|F1N1T1-1|A0AAA9TBT0_BOVIN Computationally mapped isoform of N6-Methyl-AMP deaminase OS=Bos taurus OX=9913 GN=ADAL PE=3 SV=2 CANONICAL=A0AAA9TBT0-1" }, "locus": { "chromosome": "21", "start_pos": 55108731, "end_pos": 55093357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019248.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019248.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019248.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019248.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2161541", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2161541", "resource": "Reactome", "description": "Abacavir metabolism" }, { "id": "R-BTA-74217", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74217", "resource": "Reactome", "description": "Purine salvage" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "nucleotide metabolic process", "id": "GO:0009117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0" } ], "pmid": "" }, { "name": "toxic metabolite repair", "id": "GO:0110052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110052", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0" } ], "pmid": "" }, { "name": "adenosine catabolic process", "id": "GO:0006154", "url": 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"name": "adenosine deaminase activity", "id": "GO:0004000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16001", "name": "", "equation": "N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VC13-1" ], "evidence": [ { "id": "16001", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16001" } ] }, { "id": "86223", "name": "", "equation": "N(6),N(6)-dimethyl-AMP + H2O + H(+) = dimethylamine + IMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VC13-1" ], "evidence": [ { "id": "86223", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/86223" } ] }, { "id": "86227", "name": "", "equation": "N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O + H(+) = dimethylallylamine + IMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VC13-1" ], "evidence": [ { "id": "86227", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/86227" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q0VC13", "gene_name": "MAPDA", "activity": [ { "ec_number": "3.5.4.-", "activity": "", "evidence": [ { "id": "Q0VC13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC13" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT0" }, { "id": "PS51671", "database": "PROSITE", "url": 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the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345" }, "gene_names": [ { "name": "OR8B1AN", "type": "recommended", "evidence": [ { "id": "A0AAA9TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" } ] }, { "name": "OR8B1AN", "type": "synonym", "evidence": [ { "id": "NP_001377345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 147", "type": "synonym", "evidence": [ { "id": "NP_001377345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345" } ] }, { "name": "olfactory receptor family 8 subfamily B member 1AN", "type": "synonym", "evidence": [ { "id": "NP_001377345", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8B1AN", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3", "locus": { "chromosome": "29", "start_pos": 27673064, "end_pos": 27673993, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000063301", "url": "https://www.ensembl.org/id/ENSBTAG00000063301" } ] } } ], "crossref": [ { "id": "A0AAA9TBT3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TBT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "785107", "url": "https://www.ncbi.nlm.nih.gov/gene/785107", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785107", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785107", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377345", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGNGSSVTQFIFLGLTDQPDLQLPLFFLFLVMYMVTVMGNLGLLILIGLSSHLYMPMYFFLFNLSFIYLCYSSVFTLKMLINLISKKNIISYMGCMTQLYFLSFFVISECYVLISMAYDRYVAICNPLLYNVAMTPKVCSSLMLGSYFMAFAGAMVLTECMLRLTFCEANTINHYMCDIMPLLKLSCTSTYVNELVDSITSGFNVIVPSITIFVSYVFIFSSILQISSKEGRSKVFGTCSSHVIAVSLFFGSISFVYLKPSSAVSMDEGKISSVFYTNMVPLLNPLIYSLRNEDVKLALRKTLPRWF", "length": 309, "header": "tr|A0AAA9TBT3-1|A0AAA9TBT3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8B1AN PE=3 SV=1 CANONICAL=A0AAA9TBT3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3/entry#A0AAA9TBT3-1", "sequence": { "sequence": "MAPGNGSSVTQFIFLGLTDQPDLQLPLFFLFLVMYMVTVMGNLGLLILIGLSSHLYMPMYFFLFNLSFIYLCYSSVFTLKMLINLISKKNIISYMGCMTQLYFLSFFVISECYVLISMAYDRYVAICNPLLYNVAMTPKVCSSLMLGSYFMAFAGAMVLTECMLRLTFCEANTINHYMCDIMPLLKLSCTSTYVNELVDSITSGFNVIVPSITIFVSYVFIFSSILQISSKEGRSKVFGTCSSHVIAVSLFFGSISFVYLKPSSAVSMDEGKISSVFYTNMVPLLNPLIYSLRNEDVKLALRKTLPRWF", "length": 309, "header": "tr|A0AAA9TBT3-1|A0AAA9TBT3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8B1AN PE=3 SV=1 CANONICAL=A0AAA9TBT3-1" }, "locus": { "chromosome": "29", "start_pos": 27673993, "end_pos": 27673067, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096707.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096707.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094143.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785107", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785107", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBT3" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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160382.0, "monoisotopic_mass": 160382.0 }, "refseq": { "ac": "XP_024834328", "name": "Fanconi anemia group A protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834328" }, "gene_names": [ { "name": "FANCA", "type": "recommended", "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ] }, { "name": "FANCA", "type": "synonym", "evidence": [ { "id": "XP_024834328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834328" } ] } ], "protein_names": [ { "name": "FA complementation group A", "type": "synonym", "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1/entry#names_and_taxonomy" } ] }, { "name": "Fanconi anemia group A protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024834328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834328" } ] } ], "function": [], 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"url": "https://www.ebi.ac.uk/interpro/entry/IPR003516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618375", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618375", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AIPHCPA", "url": "https://omabrowser.org/oma/group/AIPHCPA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B6X8", "url": "https://www.orthodb.org/?gene=E1B6X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12047", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12047", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12047:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12047:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03511", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03511", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15865", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15865", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24783", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024834328", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834328", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6X8", "url": "https://www.uniprot.org/uniprotkb/E1B6X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B6X8-1", "url": "https://www.uniprot.org/uniprotkb/E1B6X8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAPGARVAASDQGPGVRRRAWAELLEGRVERQKLSPEGEQKVRESAVRLLRSHLNLNDLILEVEGPPCDQPCLRQLIDCDGPEAHTNLSSSLIGSALRDQATRLGVPVAVLSSQVVASGLMRICEADTRPPPKVLLTPEQRKKLSSLLEIAQNLLAQNMFSRLYFCQELWKAQNSLLLEAVWRLHVQNVVSIPELLESRADTQAVVVWLCKDLGLLCEQIEVPCPHAEVARAVLADLVQMFVLRGFQKSDGVRGDGAPAQMAQIAAAVLEQMLASTLEAMAAGLPEGSPAYKAGSCWFSVFSGPMYQSILSAETLKRWFCHTLTQILTHKPVLKVSDAVQMQREWSFARTPALLSGLYRRLFVILSPEELVGHLQDVLETQEVNWRHVLSCVSTLVICLPDAQQLVNGWVTRLLARAFESWDLDSMVLAFLVVRQAALEGPAVFPSYATWFQATFGSTRGIHSCSKKALVFLFKFLSDLVPFEVPRYLQVHILHPPLVPGKYRTLLTDYVVLAKTRLADLKISIENMGLYEDLSSAGDVTQPQSQASQDVEKALSVFEHTGKVPVAILEASIFRRSYYLSHFLPALLTPRVLPRAPDSREALIESLRRADKIPPALYSAYRQACSTAGQKQPEDAAQGGEVEPSCAEEPLDLLMAALQELRASMTDPTQHDELSAQVAMVSERLHSVLGLSEDVSSDEAAPVQLSVQAPKLQPLEQRVVDLLLTSFCQNLMAASSVAPPDRQGPWATHFVRALCGHRFLPAVLTRLCQLLHHQGPSLSASHVLGLAALAVHLGESRSELPKVHVGPPAPARGLPIPEFIDSLLPCTAQQASALCLKFSTAAISYSLCKFSQSHELLHSCLSPGLIKKFQFLMFRWFPEARDPPSQEDPASLPWRPLCLPSVDWRRAALCLWKQRALKELLKQEGLQLTYRDWLQLEIEIQPEVDSLSDTERQDFQQWAIHQHFLPMPSATGGCDGDLEAACTTLVDVLMDFCQSSRSHHHSENSDLVLSGCKGNRDIFSRLQEMAADLEQGPAPLGHAAPHGHFLFGVFRRRLQALTHGWDMASRLQRQRELLTCKRTLLGLPPSMLVSSPRAEQPAAPSCTDFFHLVNSELRNFSHDGALTHDITAHFFRGLLNTCARSRDPSLAADLALTACQTQCPLLLTSALLWWSSLEPELHCRWRRWSQSPLPAELRKLQEAHLFAESVSSPLTPSPAPGPSWLCAAALHFAIQRARKESFRQELGKLDGQGEELFVSLFFFSLMGLLSSYLTPQAIGSLRALDICADILGCLQRRRISWLLVFQLTEADVPLGRTLLGLAPDHQVRLLPVAFYSLLPYFDEDALLTEDAFLHVALNMYLKLVGLFVAGETGAIWTVAHDGELPTQGDPVSLITNARLFLLQLIPRCPERSFLHVAELLAESGDCDPEVSAALLSRRQAVLDPDLSQEPQLF", 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"MSAPGARVAASDQGPGVRRRAWAELLEGRVERQKLSPEGEQKVRESAVRLLRSHLNLNDLILEVEGPPCDQPCLRQLIDCDGPEAHTNLSSSLIGSALRDQATRLGVPVAVLSSQVVASGLMRICEADTRPPPKVLLTPEQRKKLSSLLEIAQNLLAQNMFSRLYFCQELWKAQNSLLLEAVWRLHVQNVVSIPELLESRADTQAVVVWLCKDLGLLCEQIEVPCPHAEVARAVLADLVQMFVLRGFQKSDGVRGDGAPAQMAQIAAAVLEQMLASTLEAMAAGLPEGSPAYKAGSCWFSVFSGPMYQSILSAETLKRWFCHTLTQILTHKPVLKVSDAVQMQREWSFARTPALLSGLYRRLFVILSPEELVGHLQDVLETQEVNWRHVLSCVSTLVICLPDAQQLVNGWVTRLLARAFESWDLDSMVLAFLVVRQAALEGPAVFPSYATWFQATFGSTRGIHSCSKKALVFLFKFLSDLVPFEVPRYLQVHILHPPLVPGKYRTLLTDYVVLAKTRLADLKISIENMGLYEDLSSAGDVTQPQSQASQDVEKALSVFEHTGKVPVAILEASIFRRSYYLSHFLPALLTPRVLPRAPDSREALIESLRRADKIPPALYSAYRQACSTAGQKQPEDAAQGGEVEPSCAEEPLDLLMAALQELRASMTDPTQHDELSAQVAMVSERLHSVLGLSEDVSSDEAAPVQLSVQAPKLQPLEQRVVDLLLTSFCQNLMAASSVAPPDRQGPWATHFVRALCGHRFLPAVLTRLCQLLHHQGPSLSASHVLGLAALAVHLGESRSELPKVHVGPPAPARGLPIPEFIDSLLPCTAQQASALCLKFSTAAISYSLCKFSQSHELLHSCLSPGLIKKFQFLMFRWFPEARDPPSQEDPASLPWRPLCLPSVDWRRAALCLWKQRALKELLKQEGLQLTYRDWLQLEIEIQPEVDSLSDTERQDFQQWAIHQHFLPMPSATGGCDGDLEAACTTLVDVLMDFCQSSRSHHHSENSDLVLSGCKGNRDIFSRLQEMAADLEQGPAPLGHAAPHGHFLFGVFRRRLQALTHGWDMASRLQRQRELLTCKRTLLGLPPSMLVSSPRAEQPAAPSCTDFFHLVNSELRNFSHDGALTHDITAHFFRGLLNTCARSRDPSLAADLALTACQTQCPLLLTSALLWWSSLEPELHCRWRRWSQSPLPAELRKLQEAHLFAESVSSPLTPSPAPGPSWLCAAALHFAIQRARKESFRQELGKLDGQGEELFVSLFFFSLMGLLSSYLTPQAIGSLRALDICADILGCLQRRRISWLLVFQLTEADVPLGRTLLGLAPDHQVRLLPVAFYSLLPYFDEDALLTEDAFLHVALNMYLKLVGLFVAGETGAIWTVAHDGELPTQGDPVSLITNARLFLLQLIPRCPERSFLHVAELLAESGDCDPEVSAALLSRRQAVLDPDLSQEPQLF", "length": 1449, "header": "tr|A0AAA9TBU1-1|A0AAA9TBU1_BOVIN Isoform 1 of FA complementation group A OS=Bos taurus OX=9913 GN=FANCA PE=4 SV=1 CANONICAL=A0AAA9TBU1-1" }, "locus": { "chromosome": "18", "start_pos": 14644928, "end_pos": 14607451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132412.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132412.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094321.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094321.1" } ] } }, { "isoform_ac": "E1B6X8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1/entry#E1B6X8-1", "sequence": { "sequence": "MSAPGARVAASDQGPGVRRRAWAELLEGRVERQKLSPEGEQKVRESAVRLLRSHLNLNDLILEVEGPPCDQPCLRQLIDCDGPEAHTNLSSSLIGSALRDQATRLGVPVAVLSSQVVASGLMRICEADTRPPPKVLLTPEQRKKLSSLLEIAQNLLAQNMFSRLYFCQELWKAQNSLLLEAVWRLHVQNVVSIPELLESRADTQAVVVWLCKDLGLLCEQIEVPCPHAEVARAVLADLVQMFVLRGFQKSDGVRGDGAPAQMAQIAAAVLEQMLASTLEAMAAGLPEGSPAYKAGSCWFSVFSGPMYQSILSAETLKRWFCHTLTQILTHKPVLKVSDAVQMQREWSFARTPALLSGLYRRDPTLLSRLPAAVCPRTHCQAACRPPPMLGDRCGQVDGWVTRLLARAFESWDLDSMVLAFLVVRQAALEGPAVFPSYATWFQATFGSTRGIHSCSKKALVFLFKFLSDLVPFEVPRYLQVHILHPPLVPGKYRTLLTDYVVLAKTRLADLKISIENMGLYEDLSSAGDVTQPQSQASQDVEKALSVFEHTGKVPVAILEASIFRRSYYLSHFLPALLTPRVLPRAPDSREALIESLRRADKIPPALYSAYRQACSTAGQKQPEDAAQGGEVEPSCAEEPLDLLMAALQELRASMTDPTQHDELSAQVAMVSERLHSVLGLSEDVSSDEAAPVQLSVQAPKLQPLEQRVVDLLLTSFCQNLMAASSVAPPDRQGPWATHFVRALCGHRFLPAVLTRLCQLLHHQGPSLSASHVLGLAALAVHLGESRSELPKVHVGPPAPARGLPIPEFIDSLLPCTAQQASALCLKFSTAAISYSLCKFSQSHELLHSCLSPGLIKKFQFLMFRWFPEARDPPSQEDPASLPWRPLCLPSVDWRRAALCLWKQRALKELLKQEGLQLTYRDWLQLEIEIQPEVDSLSDTERQDFQQWAIHQHFLPMPSATGGCDGDLEAACTTLVDVLMDFCQSSRSHHHSENSDLVLSGCKGNRDIFSRLQEMAADLEQGPAPLGHAAPHGHFLFGVFRRRLQALTHGWDMASRLQRQRELLTCKRTLLGLPPSMLVSSPRAEQPAAPSCTDFFHLVNSELRNFSHDGALTHDITAHFFRGLLNTCARSRDPSLAADLALTACQTQCPLLLTSALLWWSSLEPELHCRWRRWSQSPLPAELRKLQEAHLFAESVSSPLTPSPAPGPSWLCAAALHFAIQRARKESFRQELGKLDGQGEELFVSLFFFSLMGLLSSYLTPQAIGSLRALDICADILGCLQRRRISWLLVFQLTEADVPLGRTLLGLAPDHQVRLLPVAFYSLLPYFDEDALLTEDAFLHVALNMYLKLVGLFVAGETGAIWTVAHDGELPTQGDPVSLITNARLFLLQLIPRCPERSFLHVAELLAESGDCDPEVSAALLSRRQAVLDPDLSQEPQLF", "length": 1438, "header": "tr|E1B6X8-1|E1B6X8_BOVIN Computationally mapped isoform of FA complementation group A OS=Bos taurus OX=9913 GN=FANCA PE=4 SV=3 CANONICAL=A0AAA9TBU1-1" }, "locus": { "chromosome": "18", "start_pos": 14644928, "end_pos": 14607451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002478.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002478.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002478.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002478.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618375", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618375", "resource": "KEGG Pathway" }, { "id": "R-BTA-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AGX8-1", "protein_name": "FA complementation group A", "gene_name": "Fanca", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGSPARGAAVGGGPRVLRKTWTELLAGRVKKQKYDPEREQKLKDSALKLLRYHQNMHDLLLEAEVPQCKKLRLSELIDCGGAEASSDPSTPFIRSAFRDQASRLGVPVGVLSARVFAHSVQQVCVEPSHPVLLSPEQSERLSSLLVSAQRLLAHNMFSRLTFCQELWKAQNSLLLEAVWRLHTHHVVSLQELLQSHPDTEAMTTWLFRNLRFLCELIGASCPSSDTVEAMLSGLVQLLISWGFQGSSDPRRLLESEKIEKMPQEVRKLPRVAADVLQRMLAFSLDTLDADSQTTLDHQAVSGWITVYSGRTCCGMIAADSLKSFLSHALTQILTHKPVLKVSDAIQMQKEWSFAKTPHLLIDLYCRVFVTLGPEESIGHLQEVLELQEVNWQHVLSCVSTLVVCFSEAQQLIKDWVASLMARAFESYHLDSMVTAFLIVRQATLEGPYVFPSYADWFKESFGSSHGYHSCSKKTLVFLFKFLSDLVPWEAPRHMQVHIFHPPLVPSKYHSLLTDYISLAKTRLADLKVSLENVGLYEDLSSTGDIAERESQAVQDVKKAIMVFEQTGKIPMPVLEASIFRRPYYLSHFLPALLAPRVLPEVPDSRVAFIETLKRADKIPPSSYSAYRQACATAGDKQPDNTTSGQRTETNCAERPLGLLTAALEELRALMTDPTQYSVISAQVAVVSERLNAALGHRNDDDVSLRRSKIQLSVLLPTLQSQDQGVVDLLLTAFCQNLMAACSFVPPERQSSWAVLFVRTLCGHMLLPAVLTRLCQLLRHQGPNLSAPHVLGLAALAVHLGECRSTLPEVDPGVLAPPSSLCVPDFLNSLLTCHTRDSLLFCMKFCTAAISYCLCKFSAQPSASLHNCLSPGLIQKFQFIVLRLFPEARAPCSPEHTARIPWKLLYLPSADWPRAALSLWRWSSFQELLKEEEFHLTYRDWIQLELEIQPEADALSGTERHDFHQWAIYERYLPAPSAMGGCGGDLEAACTVLVSELMDFHQRSYNHSEDSDLVLGGRTGNEDLLSRLQEMAMDLELDQGSAVPRGCSTPESHFLFRVFRGRLQALARPGSMATSLRRQQELLICKRLLLRLPPSVLVGSPQAGQPVSPNCEEFFNLVTSGLRNICCHGSVLTYDLTIHFFRGLLNVCLRSQDPALVANRTLAECQTKCPMILTSALLWWSSLEPVLCSQWKKCYQSTLPQELQRLQEARKFASNFASDSAAPAPSPAWISAAALYFATREAGRENVTTHLKRLDCEREELLITLLFFSLMGLLSSYLTQRDTAEYQKAVDICAEVLACLERRKVSWLMLFQLAETDAKLGHLLLLAPDQHTRLLPLAFYSLLSCFSDGTTVREAAFLHVAVDMYLKLVQLFVDGETRIVLPQASRSISELQDSPVQLITKARSFLLQLIPQCPRQCFSNMTELLAGRGDCDPEVSNALQQRQQAGPSFDLSQEPHLF", "length": 1458 }, "evidence": [ { "id": "A0AAA9TBU1", "url": "https://omabrowser.org/oma/group/A0AAA9TBU1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LKC7-1", "protein_name": "FA complementation group A", "gene_name": "FANCA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRQRGPDAASGRGVWAFGMSASGARGAFPDSGSGRCKRAWTELLAGRVKRQKLGPDGEQKVRESAVRLLRSHLNLSDLFLEVEGPQFAEPRLHRWIEWGGPEADARLSSSFVGSALQDQASRLGVPVAVLSSRVVASALARICASDARPSPQMLLTPEQRKKLSSVLGTARDLIAHGMFSRRCFCGEVWKVQNSLLLEAVWHLHVQNIVSLQELLESHADVQAAGTWLSRSLYHLCEQMEASSPHTDVARAVLTGFVQMFVLRGFPKNVDPRSTVEPEPVTQIAADVLQRMLTSALEALAAGLQEASAAYKAVRCWFGTFGRHTYQSIISTESPKRFFCHTLTQILTHRPVLKVSDALQMQREWCFARTHPLLSDLYRKLFVVLSPEELVARLQEVLETQEVNWQHVLSCVSALVICLPDAQPLVNGWVARLLARAFESCDLDSMVSAFLVVRQAAQEGPAAFPPYADWFQASFGSARYHGCSKKALVFLFKFLSDLVPFEAPQYLKVHMLHPPLVPSKHRTLLSDYVALARTRLADLKVSVETMGLYEDVSAAGDMAEPHSQASRDVEKAVSVFQHTGKVPVAVMEASVFRRPYYLSHFLPALLTPRVLPTVEDARAALIEALRRADKIPPSLYSAYRQACSTAGEKQPEAPGSEAEHSCAEEPLDLLTAALGELRASLSDPTQQDVLSARMAVVSDRLGPALGLSKDDEDGSSVATVQLSVRTPELPPRELKVVDLLLTAFSQNLLAASCLAPPDRQGPWAARLVRTLCGHGLLPAVLTRLCQLLRHQGPSLSASHVLGLAALAVHLGEAASTLPAVCAGPPGPARPLPVPELFDCLLPCGTPEAWALCLRFCTAAISYSVCKFSSQSRGVLRSCLSPGLIKKFQFLVLRLFPEARDAPAGAEDAAGPGWQPLCLPSVDWQRAALCLWEQGAFRELLEQDGLRLTYRDWLLLELEIQPEVDALSDTERWAFQQWAIHEHFLPAPASAGGCAGDLEAACTVLADVLMDFWQRSRSDGHSDNSHLAVSGYTGNRDIFSRLQELAGDLQQGPEAPLGPSPARGHFLFGLFRRRLRALARGQDVATRLQRQQELLMFRRVLLGLPPTVLVGSPQAGPPAALACEDFFHLVNTELRDFSQDGALSHDITLHFFRGLLDACSRSSDPSLAADLTLTACGTQCPLLLTSALLWWPRLEPELRRRWTRCSRGPLPSELQRLQEARHFARSVLGPLEAPPAPGPAWLCAAALHLELRQAGKAGLRSELARLPCPGDELLLFLFFFSLMGLLASHVTPHAAGSPEALAVCTEILGCLQRRRVSWLPLFQLTEAGAGLGHTLLRLAPDHLLRLLPVAFYSLLSSFEEDAPLQQEAFLHVAVDMYLQLVRLFMDGGTSAVSTRAHSGELRGQGDPVSLITKARLFLLQLIPRCPARSFACVTELLAAPGACDPEVRAALLRRQPAGLDPDLRQEPCLFGPDLHGV", "length": 1476 }, "evidence": [ { "id": "A0AAA9TBU1", "url": "https://omabrowser.org/oma/group/A0AAA9TBU1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15360-1", "protein_name": "Fanconi anemia group A protein", "gene_name": "FANCA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHSSSFIGSALQDQASRLGVPVGILSAGMVASSVGQICTAPAETSHPVLLTVEQRKKLSSLLEFAQYLLAHSMFSRLSFCQELWKIQSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGFQKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQILTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLLEDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPRYLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVSIENMGLYEDLSSAGDITEPHSQALQDVEKAIMVFEHTGNIPVTVMEASIFRRPYYVSHFLPALLTPRVLPKVPDSRVAFIESLKRADKIPPSLYSTYCQACSAAEEKPEDAALGVRAEPNSAEEPLGQLTAALGELRASMTDPSQRDVISAQVAVISERLRAVLGHNEDDSSVEISKIQLSINTPRLEPREHMAVDLLLTSFCQNLMAASSVAPPERQGPWAALFVRTMCGRVLPAVLTRLCQLLRHQGPSLSAPHVLGLAALAVHLGESRSALPEVDVGPPAPGAGLPVPALFDSLLTCRTRDSLFFCLKFCTAAISYSLCKFSSQSRDTLCSCLSPGLIKKFQFLMFRLFSEARQPLSEEDVASLSWRPLHLPSADWQRAALSLWTHRTFREVLKEEDVHLTYQDWLHLELEIQPEADALSDTERQDFHQWAIHEHFLPESSASGGCDGDLQAACTILVNALMDFHQSSRSYDHSENSDLVFGGRTGNEDIISRLQEMVADLELQQDLIVPLGHTPSQEHFLFEIFRRRLQALTSGWSVAASLQRQRELLMYKRILLRLPSSVLCGSSFQAEQPITARCEQFFHLVNSEMRNFCSHGGALTQDITAHFFRGLLNACLRSRDPSLMVDFILAKCQTKCPLILTSALVWWPSLEPVLLCRWRRHCQSPLPRELQKLQEGRQFASDFLSPEAASPAPNPDWLSAAALHFAIQQVREENIRKQLKKLDCEREELLVFLFFFSLMGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESDLRLGRLLLRVAPDQHTRLLPFAFYSLLSYFHEDAAIREEAFLHVAVDMYLKLVQLFVAGDTSTVSPPAGRSLELKGQGNPVELITKARLFLLQLIPRCPKKSFSHVAELLADRGDCDPEVSAALQSRQQAAPDADLSQEPHLF", "length": 1455 }, "evidence": [ { "id": "A0AAA9TBU1", "url": "https://omabrowser.org/oma/group/A0AAA9TBU1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JL70-1", "protein_name": "Fanconi anemia group A protein homolog", "gene_name": "Fanca", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPGSPARGAAMGGGPRGLRKTWTELLAGRVKKQKYDPEREQKLKDSALKLLRYHQNMHDLLLEVEEPQCKRLRLSELIDRDSADASSDRSASFIRSAFRDQASRLGVPVGVLSAKVFARSVQQVCVEPSHPVLLSPEQSKKLSSLLMIARHLLAQNMFSRLTFCQELWKAQNSLLLEAMWRLHTHSVVSLQELLQSHPDSEAMAMWLFRNLRSLCEQIGASCPSPDTTEAMLSGLVQLLISRGFQGSSDPRRLVEPERLPQVATDVLQRMLAFSLDTLEADPQTTLDCQAVSGWIPIYSGHTCCGVVTENSLKSFFSHTLTQILTHKPVLKVSDAIQMQKEWSFAKTHHLLTDLHCRVLATLGPEESVGRLQEVLEMQEVNWQHVLSCVSTLVVCFPEAQQLVKGWVASLMARAFESYHLDSMVTAFLIVRQATLEGPYVFPSYADWFKESFGSSHGYHSCSKKTLVFLFKFLSDLVPWEAPRYMQVHIFHPPLVPSKYHSLLTDYISLAKTRLADLKVSLENVGLYEDLSSPGDIAERESQAVQDVKKAIMVFEQTGKIPMPVLEASIFRRPYYVSHFLPTLLAPRVLPEVPDPRVALIETLKRADKIPSSIYDAYRKACASAEKQQPENATSAQRTEADCAKEPLGLLTAALEELRALMTDPTQYSVISAQVAVVSEKLNAVLGHRNDGGSLQRAKIQLSVLPSTLQKQDQAVVDLLLTAFCQNLMAASSFVPPERQSPWAVLFVRTLCGHVLLPAVLTRLRQLLRHQGQSLSTSHVLGLAALAVHLGECRSMLPEVDPDVLAPSAGSLCVPDFLNSLLTCRTRDSLLFCMNFCTAAVSYCLCKFSALRNCLSPGLIKKFQFVVLRLFPEARAPCAPEHAACVPWRPLYLPSADWQRAALSLWRRDSFQELLKDKEFYLTYRDWVQLELEIQPEADVLSDMERHDFHQWAIYERYLPAPTALGGCGGDLEEACTVLVSEIMDFHQSSRSYNHSEDSDLVLGGRTGNKDILSRLQEIALDLELDQGSAVPHGCSTPQSHFLFRVFRRRLQALARPDSMATSLRRQQELLTCKRLLLCLPPSVLVGGPQAGQPISPNCGEFFSLVNSELRNFCCHGSVLTSDITIHFFRGLLRVCLRSQDPALVANQTLTECQTKCPVILTSALLWWSSLEPVLCGRWMRCYQSPLPRELRRLQEAREFASNFASASASPAPSPAWIAAAALHFAWRGVRKEDVTAHLQRLDCQREELLIALFFFSLMGLLSSYLTQRDTAEHLKAVDICAEVLTCLERRKVSWLVLFQLTEKDAKLGHLLHLAPDQHTRLLPLAFYSLLSCFSEGAAVREAAFLHVAVDMYLKLLQLFVDGETRLQGHSESQGSPVQLITKARVFLLQLIPQCPKQCFSNMTELLAGRGDCDPEVSNALRQRQQADPSFDLYQEPQLF", "length": 1439 }, "evidence": [ { "id": "A0AAA9TBU1", "url": "https://omabrowser.org/oma/group/A0AAA9TBU1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ], "pmid": "" }, { "name": "regulation of regulatory T cell differentiation", "id": "GO:0045589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1115, "end_pos": 1117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" }, { "id": "PF03511", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03511" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fanconi anaemia group A protein C-terminal", "eco_id": "ECO_0000259", "start_pos": 1221, "end_pos": 1425, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" }, { "id": "PF15865", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fanconi anaemia group A protein N-terminal", "eco_id": "ECO_0000259", "start_pos": 170, "end_pos": 524, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" }, { "id": "PF24783", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24783" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fanconi anaemia group A protein arcN subdomain", "eco_id": "ECO_0000259", "start_pos": 649, "end_pos": 881, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TBU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU1" }, { "id": "PF24781", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24781" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fanconi anaemia group A protein helical", "eco_id": "ECO_0000259", "start_pos": 544, "end_pos": 625, "start_aa": "Gln", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1115, "end_pos": 1117 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"MLYTLRVSNIHLAQQGETGQASRPRSPFLSTTVGGSEQLTVARKDTELPHPLHRHPRGVLTLPKSDVLIKDKDVAFLSVGAAAAFVDARDTFVVPHLLHLLHRVHGLHVVADEPQACGVQLLLVACPGVVVLQPQVLGGEEFGEEPDEQPGGEVAHGEALLHDLAHFFVGQQVRRRHREVGRGHHQLVQGDLAEVLAAPFGGQRGPLKFLPEPLRVDCIAGQVPALRARNVDLALLLVGAPLLRVPAPAALVQFAHELQCPDTVILGPWVEKLHVVADELDTGRVQLLLAQGAAAVVLLAQVLVGEELREQVHQQARGKVADGQAALVDAAQLLLAQQAVGARHLEVGLRDLQLVEVDGHQPDLLGPPAGPLALEAVFHLDHGDVIGQAG", "length": 390, "header": "tr|A0AAA9TBU7-1|A0AAA9TBU7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9TBU7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBU7/entry#A0AAA9TBU7-1", "sequence": { "sequence": "MLYTLRVSNIHLAQQGETGQASRPRSPFLSTTVGGSEQLTVARKDTELPHPLHRHPRGVLTLPKSDVLIKDKDVAFLSVGAAAAFVDARDTFVVPHLLHLLHRVHGLHVVADEPQACGVQLLLVACPGVVVLQPQVLGGEEFGEEPDEQPGGEVAHGEALLHDLAHFFVGQQVRRRHREVGRGHHQLVQGDLAEVLAAPFGGQRGPLKFLPEPLRVDCIAGQVPALRARNVDLALLLVGAPLLRVPAPAALVQFAHELQCPDTVILGPWVEKLHVVADELDTGRVQLLLAQGAAAVVLLAQVLVGEELREQVHQQARGKVADGQAALVDAAQLLLAQQAVGARHLEVGLRDLQLVEVDGHQPDLLGPPAGPLALEAVFHLDHGDVIGQAG", "length": 390, "header": "tr|A0AAA9TBU7-1|A0AAA9TBU7_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0AAA9TBU7-1" }, "locus": { "chromosome": "9", "start_pos": 42930060, "end_pos": 42923986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107919.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107919.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096187.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], 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{ "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523" }, "gene_names": [ { "name": "OR51A3", "type": "recommended", "evidence": [ { "id": "A0AAA9TBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2" } ] }, { "name": "OR51A3", "type": "synonym", "evidence": [ { "id": "NP_001377523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523" } ] } ], "protein_names": [ { "name": "Olfactory receptor family 51 subfamily A member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9TBV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 51A4", "type": "synonym", "evidence": [ { "id": "NP_001377523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523" } ] }, { "name": "olfactory receptor family 51 subfamily A member 3", "type": "synonym", "evidence": [ { "id": "NP_001377523", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TBV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51A3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2", "locus": { "chromosome": "15", "start_pos": 50020161, "end_pos": 50019208, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066146", "url": "https://www.ensembl.org/id/ENSBTAG00000066146" } ] } } ], "crossref": [ { "id": "A0AAA9TBV2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TBV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15222", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15222", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788777", "url": "https://www.ncbi.nlm.nih.gov/gene/788777", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788777", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788777", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377523", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPLNDTNIEVLRFFLIGIPGLEKSHFWISIPFSSVYFLSLLGNFTILFFIKTEPSLHEPTHYFLSMLSISDLGLSLSFSPITLGLFLFGVHGIHAATCFAQEFFIHLFTVIEASVLLVMAFDQYVAMHHPLRYSTILTSSQVIKTGVLLTSKNIMLILPLPFLLQRLTYCHQNLLLHSYCLHQGVMKVACSDNRVNVVYGLCATLSSILDLLFITFSYMMILKTVLGIATPREQPKALNTHISHICAVLIFCVPVLSAAMLHQFASGVSPMIHILMADVFLLVPLLMNPIVSCVKTHQIRKKVMGKFCSKRSLSMQ", "length": 317, "header": "tr|A0AAA9TBV2-1|A0AAA9TBV2_BOVIN Isoform 1 of Olfactory receptor family 51 subfamily A member 3 OS=Bos taurus OX=9913 GN=OR51A3 PE=3 SV=1 CANONICAL=A0AAA9TBV2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV2/entry#A0AAA9TBV2-1", "sequence": { "sequence": 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"uniprot_ac": "A0AAA9TC47", "uniprot_id": "A0AAA9TC47_BOVIN", "mass": { "chemical_mass": 26994.0, "monoisotopic_mass": 26994.0 }, "refseq": { "ac": "XP_059745914", "name": "retinoic acid early transcript 1E-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745914" }, "gene_names": [ { "name": "LOC132342095", "type": "recommended", "evidence": [ { "id": "A0AAA9TC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC47" } ] }, { "name": "LOC132342095", "type": "synonym", "evidence": [ { "id": "XP_059745914", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745914" } ] } ], "protein_names": [ { "name": "MHC class I-like antigen recognition-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0AAA9TC47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC47/entry#names_and_taxonomy" } ] }, { "name": "retinoic acid early transcript 1E-like", "type": "synonym", 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"id": "IPR002345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904044", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904044", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FECINNC", "url": "https://omabrowser.org/oma/group/FECINNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSR5", "url": "https://www.orthodb.org/?gene=A0A3Q1LSR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11430:SF65", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11430:SF65", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00061", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00061", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LSR5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSR5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASIQKICWFKSVFPRCKKTHLNLIMTYSNLFTGRWLTHFIAAENIDKITEGAPFHIFMRYIEFDEENGTIHFHFYIKKNGECIEKYVSGLKEENFYAVDYSGHNEFQVISGDKNTLITHNLNVDEDGRETEMVGLFGLSDVVDPNRIEEFKNVVREKGIPEENIRNFIYNDNCPRE", "length": 177, "header": "tr|A0AAA9TC69-1|A0AAA9TC69_BOVIN Isoform 1 of Lipocalin/cytosolic fatty-acid binding domain-containing protein OS=Bos taurus OX=9913 GN=LOC101904044 PE=3 SV=1 CANONICAL=A0AAA9TC69-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSR5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69/entry#A0A3Q1LSR5-1", "sequence": { "sequence": "MKALLLSLVLGLLAASQGDVIDASQFTGRWLTHFIAAENIDKITEGAPFHIFMRYIEFDEENGTIHFHFYIKKNGECIEKYVSGLKEENFYAVDYSGHNEFQVISGDKNTLITHNLNVDEDGRETEMVGLFGLSDVVDPNRIEEFKNVVREKGIPEENIRNFIYNDNCPRE", "length": 171, "header": "tr|A0A3Q1LSR5-1|A0A3Q1LSR5_BOVIN Computationally mapped isoform of Lipocalin/cytosolic fatty-acid binding domain-containing protein OS=Bos taurus OX=9913 GN=LOC101904044 PE=3 SV=1 CANONICAL=A0AAA9TC69-1" }, "locus": { "chromosome": "X", "start_pos": 137407596, 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"glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P08937-1", "protein_name": "Odorant-binding protein", "gene_name": "Obp1f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVKFLLIVLALGVSCAHHENLDISPSEVNGDWRTLYIVADNVEKVAEGGSLRAYFQHMECGDECQELKIIFNVKLDSECQTHTVVGQKHEDGRYTTDYSGRNYFHVLKKTDDIIFFHNVNVDESGRRQCDLVAGKREDLNKAQKQELRKLAEEYNIPNENTQHLVPTDTCNQ", "length": 172 }, "evidence": [ { "id": "A0AAA9TC69", "url": "https://omabrowser.org/oma/group/A0AAA9TC69/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small molecule binding", "id": "GO:0036094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036094", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], 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{ "uniprot_canonical_ac": "A0AAA9TC77-1", "uniprot_ac": "A0AAA9TC77", "uniprot_id": "A0AAA9TC77_BOVIN", "mass": { "chemical_mass": 46050.0, "monoisotopic_mass": 46050.0 }, "refseq": { "ac": "XP_002687737", "name": "somatostatin receptor type 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687737" }, "gene_names": [ { "name": "SSTR3", "type": "recommended", "evidence": [ { "id": "A0AAA9TC77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ] }, { "name": "SSTR3", "type": "synonym", "evidence": [ { "id": "XP_002687737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687737" } ] } ], "protein_names": [ { "name": "Somatostatin receptor 3", "type": "synonym", "evidence": [ { "id": "A0AAA9TC77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77/entry#names_and_taxonomy" } ] }, { "name": "somatostatin receptor type 3", "type": "synonym", "evidence": [ { "id": "XP_002687737", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687737" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSTR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77", "locus": { "chromosome": "5", "start_pos": 75621865, "end_pos": 75642635, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055328", "url": "https://www.ensembl.org/id/ENSBTAG00000055328" } ] } } ], "crossref": [ { "id": "cd15972", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15972", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518585", "url": "https://www.ncbi.nlm.nih.gov/gene/518585", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001856", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001856", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518585", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518585", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVPACPP", "url": "https://omabrowser.org/oma/group/EVPACPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24229:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24229:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687737", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687737", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TC77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTPGSLSLLPVTSEPGNTSSAWPPDAVLGNVSAASSAAGLAVSGILIPLVYLVVCVVGLLGNSLVIYVVLRQTATPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVRAPSCQRRRHSERKVTRMVVAVVALFVLCWMPFYVLNIINVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVQNQEPPVGPPEKTEEEEEAGDGEDRHEGAGKQGDWGEMNGRVNQIIQPGPSGQERPPSSTTSKERQFLPQEPLAGEKSDTLHISYL", "length": 422, "header": "tr|A0AAA9TC77-1|A0AAA9TC77_BOVIN Isoform 1 of Somatostatin receptor 3 OS=Bos taurus OX=9913 GN=SSTR3 PE=3 SV=1 CANONICAL=A0AAA9TC77-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TC77-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77/entry#A0AAA9TC77-1", "sequence": { "sequence": "MNTPGSLSLLPVTSEPGNTSSAWPPDAVLGNVSAASSAAGLAVSGILIPLVYLVVCVVGLLGNSLVIYVVLRQTATPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVRAPSCQRRRHSERKVTRMVVAVVALFVLCWMPFYVLNIINVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVQNQEPPVGPPEKTEEEEEAGDGEDRHEGAGKQGDWGEMNGRVNQIIQPGPSGQERPPSSTTSKERQFLPQEPLAGEKSDTLHISYL", "length": 422, "header": "tr|A0AAA9TC77-1|A0AAA9TC77_BOVIN Isoform 1 of Somatostatin receptor 3 OS=Bos taurus OX=9913 GN=SSTR3 PE=3 SV=1 CANONICAL=A0AAA9TC77-1" }, "locus": { "chromosome": "5", "start_pos": 75621921, "end_pos": 75621865, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104952.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104952.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099424.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518585", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518585", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YHV2-1", "protein_name": "Somatostatin receptor 3", "gene_name": "SSTR3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDTSAFSLPTPTVSEEGNASGSWAGFTTPNSSTTTTSPGVVVSGILIPMVYLIVCVVGLIGNSLVIYVVLRHSVSESVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMAVDAINQFTSIFCLTVMSVDRYLAVVHPGKSSKWRTARVAKAVSATVWMLSSIVVLPVVVFSDVPLGMNTCHIQWPEPASVWRAGFIIYTATLGFFGPLLVICLCYLLIVVKVRSSGRRVRALSSKHKLSERRVTRMVVTVVAVFVLCWLPFYVLNIINVVCPLPEEPSLFGVYFLVVVLPYANSCANPIIYGFLSYRFKQGFRRAIFRPSRRVQSQEVPECPPEKSDDGGEEKEISKITQNGNDREERPLSSRAGERNGQKPLPEEPVGCEKSSKLHVSYL", "length": 402 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3IM09-1", "protein_name": "Somatostatin receptor type 3", "gene_name": "Sstr3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASAAYASSVPTTLDPGNTSSAWPLDASLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVICVVLRHTASPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAAFIIYTAALGFFGPLLIICLCYLLIVVKVRSATRRVRAPSCQWVQASSCQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIINVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEEEEEEEEERREEEERRSRRKEMNGRAGQIAQPGTSGQEPSTGTAKEQQFLPQEATAGDKPGTLSHL", "length": 425 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LL93-1", "protein_name": "Somatostatin receptor 3", "gene_name": "SSTR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDTPGYPSLVPTTSEPGNASSAWSLDAVLGNGSSAPSAAGLAVRGILIPLVYLVVCVVGLLGNSLVIYVVLRQTASPSVTSIYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVRAPSCQRRRPSERRVTRMVVAVVALFVLCWMPFYVLNIINVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRNQEPPVGPPEKTEEEEEDGGEHEKGGAGNQGERKEMNGRVIQITQPGPSGQERPPSGTATKEHQFLPQEPSAGDKSGPLHISYL", "length": 421 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P30935-1", "protein_name": "Somatostatin receptor type 3", "gene_name": "Sstr3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL", "length": 428 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P30936-1", "protein_name": "Somatostatin receptor type 3", "gene_name": "Sstr3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGDKASTLSHL", "length": 428 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P32745-1", "protein_name": "Somatostatin receptor type 3", "gene_name": "SSTR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL", "length": 418 }, "evidence": [ { "id": "A0AAA9TC77", "url": "https://omabrowser.org/oma/group/A0AAA9TC77/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "somatostatin receptor activity", "id": "GO:0004994", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004994", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "ciliary membrane", "id": "GO:0060170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060170", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ], "pmid": "" }, { "name": "9+0 non-motile cilium", "id": "GO:0097731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097731", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TC77", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC77" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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"MEGNPVHRVSAGDAWSSSMHPDIESERHSQSFNVEELTNILDGGAQNTALRRKVESIIHSEPELSLKDNYFMTQNERYEAAIKKKFHILMLAQRLGWSEGSSELQYASRSVSGDLGFAIHHIFQKTIRSLGSEEQIAKWDPLCSKFQILGTYAQTELGHGTYLQGLETEATYDAATQEFVVHSPTMTAIKWWPGDLGRSATHALVQAQLICSGARQGMHAFIVPIRSLDDHSPLPGITIGDIGPKMDFEHTDNGFLKLDHVRIPRENMLNRFAQVLPDGTYVKLGVPKSNYLSMVVVRVDILLGEVLPLLQKACTIAVRYAVIRRQSRLRPSDPEAKVLDYQTQQQKLFPPLAMAYAFHFVANNLLEFFHHSYSFILDGDFALLPELHALSAGLKAMLSDFCTQGVEQCRRACGGHGYSKLSGLPSLLTRVTASCTYEGENTVLYLQTARFLIKSYLNTQKSPGSASKGSLPQSVAYLTAPDLARCPAQTAADFLQPELYTTAWAHVAVRLIKDSVHHLQTLRQAGADEHDAWNQTTVIHVQATKAHLYYVTVKIFTEALEKLESQPAIHQVLKRLSDLYALHGILTNAGDFLHDGFLSGAQIDMARKAYLDLLPFIRKDAILLTDAFDFTDQCLNSALGCYDGHAYERLFQWAQKSPTNTEGNPAYEKYIRPLLQGRRARL", "length": 682, "header": "tr|A0AAA9TCA5-1|A0AAA9TCA5_BOVIN Isoform 1 of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOX2 PE=1 SV=2 CANONICAL=A0AAA9TCA5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA5/entry#A0AAA9TCA5-1", "sequence": { "sequence": 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"header": "tr|F1MRF5-1|F1MRF5_BOVIN Computationally mapped isoform of Acyl-coenzyme A oxidase OS=Bos taurus OX=9913 GN=ACOX2 PE=1 SV=2 CANONICAL=A0AAA9TCA5-1" }, "locus": { "chromosome": "22", "start_pos": 42867103, "end_pos": 42838677, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005472.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005472.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005472.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005472.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-193368", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" }, { "id": "R-BTA-389887", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "resource": "Reactome", "description": "Beta-oxidation 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"evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA5" } ], "pmid": "" }, { "name": "very long-chain fatty acid metabolic process", "id": "GO:0000038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000038", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA5" } ], "pmid": "" }, { "name": "acyl-CoA oxidase activity", "id": "GO:0003997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003997", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCA5" } ], "pmid": "" }, { "name": 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"disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MFSD12", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3", "locus": { "chromosome": "7", "start_pos": 20381477, "end_pos": 20368841, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014979", "url": "https://www.ensembl.org/id/ENSBTAG00000014979" } ] } } ], "crossref": [ { "id": "A0AAA9TCJ3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014979", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014979", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17491", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17491", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11328:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11328:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13347", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13347", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29655", "url": "https://www.rhea-db.org/rhea/29655", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZJ3", "url": "https://www.uniprot.org/uniprotkb/F1MZJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MZJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLRLARVDAAPEIPLPTRGCPGSTSTTPAKALGGVGRRRGAPGRTGRGDPGLGVQSASAGRTGRVRSAAMGPGPPAAGAGAPLRPLSLVARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGFEADRAAGRCARFGPRKAWHLVGTICVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELVTNDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSPHTGPTEDVSDQLGVQDVPVFRNLSLLVVGVGAVFSLLFHLGTREGRRRQVEEPGEHSPLLAPSTTQPLLLWKHWLREPAFYQVGLLYMSTRLIVNLSQTYIAMYLTYSLHLPKRFIATIPLVMYLSGFCSSFLMKPVNKCIGRNMTYFVGLLVILAFAAWVALAEELGMAVYVAAVLLGMGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAIQSLHPCSLELCCKACVAFYHWVMVVVTGGVGVAATMALCSLLVWPIRLRRWDPGA", "length": 546, "header": "tr|A0AAA9TCJ3-1|A0AAA9TCJ3_BOVIN Isoform 1 of Major facilitator superfamily domain-containing protein 12 OS=Bos taurus OX=9913 GN=MFSD12 PE=3 SV=1 CANONICAL=A0AAA9TCJ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3/entry#A0AAA9TCJ3-1", "sequence": { "sequence": 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"Ensembl Peptide", "id": "ENSBTAP00000094462.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094462.1" } ] } }, { "isoform_ac": "A0AAA9TYM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3/entry#A0AAA9TYM9-1", "sequence": { "sequence": "MGPGPPAAGAGAPLRPLSLVARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGFEADRAAGRCARFGPRKAWHLVGTICVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELVTNDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSPHTGPTEDVSDQLGVQDVPVFRNLSLLVVGVGAVFSLLFHLGTREGRRRQVEEPGEHSPLLAPSTTQPLLLWKHWLREPAFYQVGLLYMSTRLIVNLSQTYIAMYLTYSLHLPKRFIATIPLVMYLSGFCSSFLMKPVNKCIGRNMTYFVGLLVILAFAAWVALAEELGMAVYVAAVLLGMGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAIQSLHPCSLELCCKACVAFYHWVMVVVTGGVGVAATMALCSLLVWPIRLRRFPCPTSQTCRPFPPGSYPGLEVCWKWSQLQLTAVCACTRVPLHTCGTLQLRWHSFS", "length": 527, "header": "tr|A0AAA9TYM9-1|A0AAA9TYM9_BOVIN Computationally mapped isoform of Major facilitator superfamily domain-containing protein 12 OS=Bos taurus OX=9913 GN=MFSD12 PE=3 SV=1 CANONICAL=A0AAA9TCJ3-1" }, "locus": { "chromosome": "7", "start_pos": 20381449, "end_pos": 20369163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115706.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115706.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103733.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103733.1" } ] } }, { "isoform_ac": "F1MZJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3/entry#F1MZJ3-1", "sequence": { "sequence": "MGPGPPAAGAGAPLRPLSLVARLSYAVGHFLNDLCASMWFTYLLLYLHSVRAYSSRGAGLLLLLGQVADGLCTPLVGFEADRAAGRCARFGPRKAWHLVGTICVLLSFPFIFSPCLGCGAATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELVTNDHEKVELTALRYAFTVVANITVYGAAWLLLHLQGSPHTGPTEDVSDQLGVQDVPVFRNLSLLVVGVGAVFSLLFHLGTREGRRRQVEEPGEHSPLLAPSTTQPLLLWKHWLREPAFYQVGLLYMSTRLIVNLSQTYIAMYLTYSLHLPKRFIATIPLVMYLSGFCSSFLMKPVNKCIGRNMTYFVGLLVILAFAAWVALAEELGMAVYVAAVLLGMGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVMAIQSLHPCSLELCCKACVAFYHWVMVVVTGGVGVAATMALCSLLVWPIRLRRSAVCACTRVPLHTCGTLQLRWHSFS", "length": 496, "header": "tr|F1MZJ3-1|A0AAA9TCJ3_BOVIN Computationally mapped isoform of Major facilitator superfamily domain-containing protein 12 OS=Bos taurus OX=9913 GN=MFSD12 PE=3 SV=4 CANONICAL=A0AAA9TCJ3-1" }, "locus": { "chromosome": "7", "start_pos": 20381449, "end_pos": 20369163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019942.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019942.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019942.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019942.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of melanin biosynthetic process", "id": "GO:0048022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048022", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "carbohydrate transport", "id": "GO:0008643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008643", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "melanin biosynthetic process", "id": "GO:0042438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042438", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "pigment metabolic process involved in pigmentation", "id": "GO:0043474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043474", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "cysteine transmembrane transport", "id": "GO:1903712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903712", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "regulation of melanin biosynthetic process", "id": "GO:0048021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048021", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCJ3" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": 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"database": "Ensembl Transcript", "id": "ENSBTAT00000110740.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110740.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096423.1" } ] } }, { "isoform_ac": "A0ABI0NML7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCM7/entry#A0ABI0NML7-1", "sequence": { "sequence": "MPLHQISVIPAREMAGNGRSSMCRNKEKSKEVENDKSPRRSASLSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQACLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKRAEKNRSCTVSMDTKDAGAVPALQTGPTARQPAEAGPTELIPV", "length": 285, "header": "tr|A0ABI0NML7-1|A0ABI0NML7_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=MARCHF1 PE=4 SV=1 CANONICAL=A0AAA9TCM7-1" }, "locus": { "chromosome": "6", "start_pos": 2104060, "end_pos": 1473603, "strand": "-", "evidence": [ { "database": "Ensembl 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376921" }, "gene_names": [ { "name": "OR8B1R", "type": "recommended", "evidence": [ { "id": "A0AAA9TCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3" } ] }, { "name": "OR8B1R", "type": "synonym", "evidence": [ { "id": "NP_001376921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376921" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9TCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 8 subfamily B member 1R", "type": "synonym", "evidence": [ { "id": "NP_001376921", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376921" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376921" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8B1R", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3", "locus": { "chromosome": "29", "start_pos": 27330651, "end_pos": 27331577, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064416", "url": "https://www.ensembl.org/id/ENSBTAG00000064416" } ] } } ], "crossref": [ { "id": "A0AAA9TCN3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516940", "url": "https://www.ncbi.nlm.nih.gov/gene/516940", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516940", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516940", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ATYMITF", "url": "https://omabrowser.org/oma/group/ATYMITF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376921", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TCN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGNNSFVTEFILLGLTDRPDLQLPLFFLFLGIYMVTVLGNLGLIILIALNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLINFTSKKNIISYMGCMAQLYFFCFFVISEIYVLTSMAYDRYVAICKPLLYNATMSPKVCSSLMLGSYLMAFSGAMAHTGCMLRLTFCDANTINHYFCDVHPLLQLSCTSTYVNELVVFIVVGINIIVPSFTIFVSYCLILTNILHIKSTEGRSKALSTCSSHIIAISLFFGSSAFMYLKPSAAGSMDEEKISSVFYTNVVSVMNPLIYSLRNKDVKTALRKTLSRR", "length": 308, "header": "tr|A0AAA9TCN3-1|A0AAA9TCN3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8B1R PE=3 SV=1 CANONICAL=A0AAA9TCN3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCN3/entry#A0AAA9TCN3-1", "sequence": { "sequence": 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"A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRP11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5", "locus": { "chromosome": "9", "start_pos": 86964642, "end_pos": 87022299, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032007", "url": "https://www.ensembl.org/id/ENSBTAG00000032007" } ] } } ], "crossref": [ { "id": "A0AAA9TCT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TCT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032007", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032007", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617450", "url": "https://www.ncbi.nlm.nih.gov/gene/617450", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000601", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000601", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617450", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617450", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HACCAQP", "url": "https://omabrowser.org/oma/group/HACCAQP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BFN8", "url": "https://www.orthodb.org/?gene=E1BFN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46876", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46876", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46876:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46876:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07502", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07502", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN8", "url": "https://www.uniprot.org/uniprotkb/E1BFN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN8-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAARESAGLGRRRPPPRRALPGLLLLCLWLPGGRAAGSPSAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGDPQEGCPGPGGGGYRARPDAIIRTKDSIAAGASFLSAPAAVQDWRQCLQACCLEPHCSVAVVELPRRPAPPATALGCYLFNCTWRGRSVCKFALHRGYSSYSLSRSPEGEQEGLEAGAPALTRASPRLEKDEPPLSKAGQDVVLHLPTDGVILDGRESTDDHAIVQYEWTLLQGDPTVDMKVPQSGTLKLSHLREGAYTFQLTVMDTAGQRSSDNVSVTVLPVAFSTVGCSSVCSRYHFFCDDGCCIDIMLACDGVEQCPDGSDEAFCQNLSDNRKMVTHRTTARPKTTGPSTDAGRSASLEKSEKATTPEQPPELSTTEKSNHSTFWGPESRIDLEMPDGGSSGKNRKEENYIFESKSNRGGGEHPAPEAGIKAMSPALGVWSLNHWTTREVFHPLFLSSSAEGKVSPLSKVQCCLWPWVWLSLLCCFSWLPVDYDW", "length": 521, "header": "tr|A0AAA9TCT5-1|A0AAA9TCT5_BOVIN Isoform 1 of Low-density lipoprotein receptor-related protein 11 OS=Bos taurus OX=9913 GN=LRP11 PE=3 SV=1 CANONICAL=A0AAA9TCT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5/entry#A0AAA9TCT5-1", "sequence": { "sequence": "MASAARESAGLGRRRPPPRRALPGLLLLCLWLPGGRAAGSPSAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGDPQEGCPGPGGGGYRARPDAIIRTKDSIAAGASFLSAPAAVQDWRQCLQACCLEPHCSVAVVELPRRPAPPATALGCYLFNCTWRGRSVCKFALHRGYSSYSLSRSPEGEQEGLEAGAPALTRASPRLEKDEPPLSKAGQDVVLHLPTDGVILDGRESTDDHAIVQYEWTLLQGDPTVDMKVPQSGTLKLSHLREGAYTFQLTVMDTAGQRSSDNVSVTVLPVAFSTVGCSSVCSRYHFFCDDGCCIDIMLACDGVEQCPDGSDEAFCQNLSDNRKMVTHRTTARPKTTGPSTDAGRSASLEKSEKATTPEQPPELSTTEKSNHSTFWGPESRIDLEMPDGGSSGKNRKEENYIFESKSNRGGGEHPAPEAGIKAMSPALGVWSLNHWTTREVFHPLFLSSSAEGKVSPLSKVQCCLWPWVWLSLLCCFSWLPVDYDW", "length": 521, "header": "tr|A0AAA9TCT5-1|A0AAA9TCT5_BOVIN Isoform 1 of Low-density lipoprotein receptor-related protein 11 OS=Bos taurus OX=9913 GN=LRP11 PE=3 SV=1 CANONICAL=A0AAA9TCT5-1" }, "locus": { "chromosome": "9", "start_pos": 87022100, "end_pos": 86966487, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110794.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110794.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095878.1" } ] } }, { "isoform_ac": "E1BFN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5/entry#E1BFN8-1", "sequence": { "sequence": "MASAARESAGLGRRRPPPRRALPGLLLLCLWLPGGRAAGSPSAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGDPQEGCPGPGGGGYRARPDAIIRTKDSIAAGASFLSAPAAVQDWRQCLQACCLEPHCSVAVVELPRRPAPPATALGCYLFNCTWRGRSVCKFALHRGYSSYSLSRSPEGEQEGLEAGAPALTRASPRLEKDEPPLSKAGQDVVLHLPTDGVILDGRESTDDHAIVQYEWTLLQGDPTVDMKVPQSGTLKLSHLREGAYTFQLTVMDTAGQRSSDNVSVTVLPVAFSTVGCSSVCSRYHFFCDDGCCIDIMLACDGVEQCPDGSDEAFCQNLSDNRKMVTHRTTARPKTTGPSTDAGRSASLEKSEKATTPEQPPELSTTEKSNHSTFWGPESRIDLEMPDGGSSGKNRKEENYIFESKSNRGGGEHPAPEAGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL", "length": 505, "header": "tr|E1BFN8-1|E1BFN8_BOVIN Computationally mapped isoform of Low-density lipoprotein receptor-related protein 11 OS=Bos taurus OX=9913 GN=LRP11 PE=3 SV=3 CANONICAL=A0AAA9TCT5-1" }, "locus": { "chromosome": "9", "start_pos": 87022100, "end_pos": 86966413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052954.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052954.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047808.3", "url": "https://www.ensembl.org/id/ENSBTAP00000047808.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617450", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617450", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B7G6-1", "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "lrp11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFPRAHHVLLCAALLWVSSSAGARSSPTSELKSRISGVEELLEEFRKQLQQDEPSSREQEGDGDRCVAGFRAAESRIIRASASIEQGAAFLSAPPRVFSWRDCARACCSLPHCTVAIIQEDLKQPDDSLRCYLFNCTYRGKSVCSFSYQPGFSTYSRLNDSSGAPGTAATDRPAGRPAPALGEEEAMMQDLDEPPRSDAGQDLVVQLPTDWAVLDGRDSTDDHHITRYEWALVRGDPSVKMKVTHPGLLKLSGLREGVYTFEITVIDTAGQKSSDNVSVSVLAPAPNAQVCTGHCSRYQFMCDDGCCIDIGYACDGKQHCPDRSDEDFCQNFDSGRKSSSSKHGADLQTEAAAQTPTEMQHTDISKPEAHQHYGFSNQDPCAAPPVVGPCKGVFPRWYYDSETGICQHFQYGGCKGNHNNFLQKSDCVNECIQKPTVAKHQTTATPLFSFKSYTTPVASVHQEKRPNPLLDSQNSLAERKTQRLLEGHPPPESGAILPLAFGLLISALLLLMVGCRLFLVRRRLKKALPLTTEESDYLINGMYL", "length": 544 }, "evidence": [ { "id": "A0AAA9TCT5", "url": "https://omabrowser.org/oma/group/A0AAA9TCT5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XMB0-1", "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "LRP11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALVLVLLAALGGRAVLPGARSAAPLADLRSQISGVESLLEEFRRQLQQEEPGPPAAAAGGGGERCGGSGGFSARPDSIIRTKDSIAAGATFLRAPDGAAGWRQCLDACCAEPRCTLAVVQGPGRPRAAAELGCFLFNCTHRGRPVCRFAPHRGYSTYSRLPAPPPADDAAASSRGAALVPPALPPEEEFDEPPVCKAGQDLVLQSPVDWVILDGRESSDDRGIVQYEWTLLQGDSSLEMKVPQPGTLKLSHLQEGTYIFQLTVTDTAGQRSMDNVSVTVLPMTHSAVACVGVCSRYQFICDDGCCIDITFACDGVKQCPDGSDETFCQNLSPGRKTVTHSAPSTTQQRTAGLTEKTDENLAAENTLKATVRNQLLLSLDADTSNQSLSQGPKKQNSGFVPDNSSSGKKTGDKNGNGLIVPKRDQLGDGHPVPETGAVLPLALGLAITALLLLMVACRLRLVRQKLKKARPITSEESDYLINGMYL", "length": 487 }, "evidence": [ { "id": "A0AAA9TCT5", "url": "https://omabrowser.org/oma/group/A0AAA9TCT5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M753-1", "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "Lrp11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARGGPGPGSRHRALRGLLLLCLWLPGGRPGEPAAPPSGVDRLLQDFRRQLQRARPREELEPELLGGPQEDCPGAGGTAVYRAVSDTIIRTQDSIAAGASFLRAPGTVRGWRQCVAACCSEPSCSVAVVQLPRGPSVPSPVPAPRCYLFNCTARGRSVCKFAPLRGYRTYTLSRAGDAAGISPGPGEDEPPVSRAGKDVVLRLPTDGVVLDGRESTDDHAIVLYEWTLQQGDPSSVDMKVPQPGTLKLSHLKEGAYVFQLTVTDSVGQRSSDNVSVTVLPRLRSTGGCSSACSRYHFFCDNGCCIDIALACDGVRQCPDGSDEDFCQNLALDRKLVTHTVATSAQPGATGLNEGEGDPWLEKSQKATTHNQPATVSHPEKRIQPTQKAPESQINPVQPDSNSSGKNQEEKYDLKSKSDQARGEHPAPEAGAVLPLALGLAITALLLLMVTCRLRLVKQKLKKARPITSEESDYLINGMYL", "length": 481 }, "evidence": [ { "id": "A0AAA9TCT5", "url": "https://omabrowser.org/oma/group/A0AAA9TCT5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86VZ4-1", "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "LRP11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASVAQESAGSQRRLPPRHGALRGLLLLCLWLPSGRAALPPAAPLSELHAQLSGVEQLLEEFRRQLQQERPQEELELELRAGGGPQEDCPGPGSGGYSAMPDAIIRTKDSLAAGASFLRAPAAVRGWRQCVAACCSEPRCSVAVVELPRRPAPPAAVLGCYLFNCTARGRNVCKFALHSGYSSYSLSRAPDGAALATARASPRQEKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDDHAIVQYEWALLQGDPSVDMKVPQSGTLKLSHLQEGTYTFQLTVTDTAGQRSSDNVSVTVLRAAYSTGGCLHTCSRYHFFCDDGCCIDITLACDGVQQCPDGSDEDFCQNLGLDRKMVTHTAASPALPRTTGPSEDAGGDSLVEKSQKATAPNKPPALSNTEKRNHSAFWGPESQIIPVMPDSSSSGKNRKEESYIFESKGDGGGGEHPAPETGAVLPLALGLAITALLLLMVACRLRLVKQKLKKARPITSEESDYLINGMYL", "length": 500 }, "evidence": [ { "id": "A0AAA9TCT5", "url": "https://omabrowser.org/oma/group/A0AAA9TCT5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CB67-1", "protein_name": "Low-density lipoprotein receptor-related protein 11", "gene_name": "Lrp11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATRGGGPGPGFRHRALRGLLLLCLWLPGSRPGEPAAPSSGVDRLLQDFRRQLQRARPREELEPELLGGPREDCPGAGGTAVYRAVPDTIIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVPAPMPAPRCYLFNCTARGRSVCKFAPLRGYRTYTLSRAEDAAGIPPRPDEDKPPVSKAGKDVVLHLPTDGVVLDGRESSDDHAIVLYEWTLQQGDPSSVDMKVPQPGTLRLSRLKEGAYIFQLTVTDSVGQRSSDNVSVTVLPRPYSTGGCSSACSRYHFFCDSGCCIDIALACDGVRQCPDGSDEDFCQNLALDRKLVTHTVATSAQPGAMGLNEGEGDPKLEKSQRATTHNQPATVSHPETRIHSTQKAPESQINPVQPDSNSSGKNQEEGNYDLKSKSGQAGGEHPAPEAGAVLPLALGLAITVLLLLMVTCRLRLVKQKLKKARPITSEESDYLINGMYL", "length": 483 }, "evidence": [ { "id": "A0AAA9TCT5", "url": "https://omabrowser.org/oma/group/A0AAA9TCT5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "response to cold", "id": "GO:0009409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009409", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "response to mechanical stimulus", "id": "GO:0009612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009612", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "response to water deprivation", "id": "GO:0009414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009414", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "response to heat", "id": "GO:0009408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009408", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" }, { "name": "multicellular organismal response to stress", "id": "GO:0033555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033555", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCT5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphoprotein binding", "id": "GO:0051219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051219", 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"publication": [], "pathway": [ { "id": "bta:520518", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520518", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PGZ5-1", "protein_name": "Cytochrome c oxidase assembly factor 7", "gene_name": "COA7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLIDFGDEEEVRSYLENLHVEYSYQCFKEKDPEGCQRLADYLDAVKKDFEAAARVLRDNCELHGHSESCYRLGAYQAIGKGGLAADLKAAYKSFLKSCEKGGKKSVNACHSVGLLAHDGRVNDDKPDPVVARDYYTKACDGNFAPSCFNLSVIYLQGAAGVPKDMNRALKYSLKGCELGHIWACANASRMYKLGDGVEKNDDKAEDLKNRAKQLHKEQKEASSSLTFGE", "length": 231 }, "evidence": [ { "id": "A0AAA9TD90", "url": "https://omabrowser.org/oma/group/A0AAA9TD90/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4AC65-1", "protein_name": "Cytochrome c oxidase assembly factor 7", "gene_name": "Coa7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"MDEGAQKRKEQESGMALSQAQLTFKDVFIDFTPEEWECLDPAQRTLYKDVMVETLGNLLSVDMSQIDMIKKLQAKADSGKGEIFQRVMFERAESLESKDFHLRKMQENIDDFDCLRTDDERNDKGLSTSHNKNLTDGRDHHSRSDAENGTFERHGSSFQDESQMMQSEGIIFECSQVVTDVSASGLSSQRTLNVCKGFSHKDENAVMHPSELLPDHETQNKRPYKCNECDITFLQDSELTRHQRIHTGGKPYKCDVCGKAFNQTRKLAIHWRIHTGEKPHKCDVCGKVFKQAAKFLIHWRYHMREKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCGKAFSHSANLTVHRRLHTGEKPYKCDVCGKAFNQTAKLRLHQRIHTGEKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCDKAFSDTSSLTVHRRLHTGEKPYKCDICGKGFSVSSSLAVHQRVHTGEKPYKCDVCGKAFNQTAKLGLHQKIHTGEKSYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDICGKAFRVSSNLAVHRRVHTGEKPYKCDVCGKAFSQATGLAVHQRIHTGEKPYKCDVCGKAFNHTTRLELHQRIHTGEKPYKCNVCDKAFSHTANLTVHRRLHTGEKPYKCDICGKGFRVSSNLGVHRSVHTGEKPYKCDVCGKAFSHTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRLHTGE", "length": 753, "header": "tr|A0AAA9TDC0-1|A0AAA9TDC0_BOVIN Isoform 1 of Zinc finger protein 665-like OS=Bos taurus OX=9913 GN=LOC100140695 PE=3 SV=2 CANONICAL=A0AAA9TDC0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDC0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0/entry#A0AAA9TDC0-1", "sequence": { "sequence": "MDEGAQKRKEQESGMALSQAQLTFKDVFIDFTPEEWECLDPAQRTLYKDVMVETLGNLLSVDMSQIDMIKKLQAKADSGKGEIFQRVMFERAESLESKDFHLRKMQENIDDFDCLRTDDERNDKGLSTSHNKNLTDGRDHHSRSDAENGTFERHGSSFQDESQMMQSEGIIFECSQVVTDVSASGLSSQRTLNVCKGFSHKDENAVMHPSELLPDHETQNKRPYKCNECDITFLQDSELTRHQRIHTGGKPYKCDVCGKAFNQTRKLAIHWRIHTGEKPHKCDVCGKVFKQAAKFLIHWRYHMREKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCGKAFSHSANLTVHRRLHTGEKPYKCDVCGKAFNQTAKLRLHQRIHTGEKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCDKAFSDTSSLTVHRRLHTGEKPYKCDICGKGFSVSSSLAVHQRVHTGEKPYKCDVCGKAFNQTAKLGLHQKIHTGEKSYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDICGKAFRVSSNLAVHRRVHTGEKPYKCDVCGKAFSQATGLAVHQRIHTGEKPYKCDVCGKAFNHTTRLELHQRIHTGEKPYKCNVCDKAFSHTANLTVHRRLHTGEKPYKCDICGKGFRVSSNLGVHRSVHTGEKPYKCDVCGKAFSHTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRLHTGE", "length": 753, "header": "tr|A0AAA9TDC0-1|A0AAA9TDC0_BOVIN Isoform 1 of Zinc finger protein 665-like OS=Bos taurus OX=9913 GN=LOC100140695 PE=3 SV=2 CANONICAL=A0AAA9TDC0-1" }, "locus": { "chromosome": "18", "start_pos": 59783180, "end_pos": 59771071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135397.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135397.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094857.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094857.2" } ] } }, { "isoform_ac": "F1MX34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0/entry#F1MX34-1", "sequence": { "sequence": "MEQLLKPMHPGEAAVNMSQIDMIKKLQAKADSGKGEIFQRVMFERAESLESKDFHLRKMQENIDDFDCLRTDDERNDKGLSTSHNKNLTDGRDHHSRSDAENGTFERHGSSFQDESQMMQSEGIIFECSQVVTDVSASGLSSQRTLNVCKGFSHKDENAVMHPSELLPDHETQNKRPYKCNECDITFLQDSELTRHQRIHTGGKPYKCDVCGKAFNQTRKLAIHWRIHTGEKPHKCDVCGKVFKQAAKFLIHWRYHMREKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCGKAFSHSANLTVHRRLHTGEKPYKCDVCGKAFNQTAKLRLHQRIHTGEKPYKCDVCGKAFSQTANLAVHQRIHTGEKPYKCNVCDKAFSDTSSLTVHRRLHTGEKPYKCDICGKGFSVSSSLAVHQRVHTGEKPYKCDVCGKAFNQTAKLGLHQKIHTGEKSYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDICGKAFRVSSNLAVHRRVHTGEKPYKCDVCGKAFSQATGLAVHQRIHTGEKPYKCDVCGKAFNHTTRLELHQRIHTGEKPYKCNVCDKAFSHTANLTVHRRLHTGEKPYKCDICGKGFRVSSNLGVHRSVHTGEKPYKCDVCGKAFSHTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRVHTGEKPYKCDVCGKAFSRTGNLAVHRRLHTGE", "length": 707, "header": "tr|F1MX34-1|F1MX34_BOVIN Computationally mapped isoform of C2H2-type domain-containing protein OS=Bos taurus OX=9913 GN=LOC100140695 PE=3 SV=4 CANONICAL=A0AAA9TDC0-1" }, "locus": { "chromosome": "18", "start_pos": 59777684, "end_pos": 59771071, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028697.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028697.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028697.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028697.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 251, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TDC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC0" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 97, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 630, "end_pos": 632 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDC6-1", "uniprot_ac": "A0AAA9TDC6", "uniprot_id": "A0AAA9TDC6_BOVIN", "mass": { "chemical_mass": 35108.0, "monoisotopic_mass": 35108.0 }, "refseq": { "ac": "NP_001377159", "name": "olfactory receptor family 8 subfamily G member 5", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377159" }, "gene_names": [ { "name": "OR8G5", "type": "recommended", "evidence": [ { "id": "A0AAA9TDC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6" } ] }, { "name": "OR8G5", "type": "synonym", "evidence": [ { "id": "NP_001377159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377159" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0AAA9TDC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 8 subfamily G member 5", "type": "synonym", "evidence": [ { "id": "NP_001377159", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377159" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377159" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6", "locus": { "chromosome": "29", "start_pos": 27531085, "end_pos": 27530144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068207", "url": "https://www.ensembl.org/id/ENSBTAG00000068207" } ] } } ], "crossref": [ { "id": "A0AAA9TDC6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "616755", "url": "https://www.ncbi.nlm.nih.gov/gene/616755", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616755", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616755", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377159", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEMAAENHSSVTEFTLAGLTEQPRLQLPLFLLFLGIYVVTVVGNLVMITLIGLSSHLHTPMYYFLTNLSFIDLCQSTVITPKMLVSSVTEKNIISYPECMTQLFFFLVFIIAECYLLAAMAYDRYVAICSPLLYNITMSHQACFSLICGVYVMGLVCAFSHIGCMLRVHFCKFDVINHYFCDLLPLLKLSCSSTYVNELLVLCFGSLNIFAPILTILSSYIFIISSTLHIHSTEGRSKAFSTCSSHISAVAIFYGSEAFMYLQPSSVSSMDQGKVSSVFYTIVVPLLNPLIYSLRNKDVNVALKKMLDRRKFL", "length": 313, "header": "tr|A0AAA9TDC6-1|A0AAA9TDC6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8G5 PE=3 SV=1 CANONICAL=A0AAA9TDC6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDC6/entry#A0AAA9TDC6-1", "sequence": { "sequence": "MEMAAENHSSVTEFTLAGLTEQPRLQLPLFLLFLGIYVVTVVGNLVMITLIGLSSHLHTPMYYFLTNLSFIDLCQSTVITPKMLVSSVTEKNIISYPECMTQLFFFLVFIIAECYLLAAMAYDRYVAICSPLLYNITMSHQACFSLICGVYVMGLVCAFSHIGCMLRVHFCKFDVINHYFCDLLPLLKLSCSSTYVNELLVLCFGSLNIFAPILTILSSYIFIISSTLHIHSTEGRSKAFSTCSSHISAVAIFYGSEAFMYLQPSSVSSMDQGKVSSVFYTIVVPLLNPLIYSLRNKDVNVALKKMLDRRKFL", "length": 313, "header": "tr|A0AAA9TDC6-1|A0AAA9TDC6_BOVIN 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"database": "Ensembl Gene", "id": "ENSBTAG00000006223", "url": "https://www.ensembl.org/id/ENSBTAG00000006223" } ] } } ], "crossref": [ { "id": "A0AAA9TDF6", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDF6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006223", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006223", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "507126", "url": "https://www.ncbi.nlm.nih.gov/gene/507126", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507126", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507126", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RPEYEVQ", "url": "https://omabrowser.org/oma/group/RPEYEVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BN78", "url": "https://www.orthodb.org/?gene=E1BN78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15215", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15215", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15215:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15215:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12736", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12736", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685734", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685734", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN78", "url": "https://www.uniprot.org/uniprotkb/E1BN78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BN78-1", "url": "https://www.uniprot.org/uniprotkb/E1BN78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVSLQDFVCALDPASLPRVLRVCSGVYFQGSIYEISGNECCLSTGDLIKVTHVRLQKVVCENPGTGQTTELAPNFQGLFSPLTGPQSYGTLEELVCAATQSSKSLPIRFMSTHRIATKARVVPQEQPLKLEAVEMHQGACCARCVLDSGAQQGFLHLPLSQQGPFWKLEPGPPRTLLQVLQDPTVRDTLLTCSAFPWRSLTLKPQYEVEAIMHFRRTVVKIPSTLEVDVEDVTTSSQHIHFIQPLLLSEALARGGPFPLATEILEVPQGSPNFLSPWLSSLQKGQRLCLHGVASPPWRFLASTRGRKVPRHFMISGAYRGKLRRRPREFPTAYDLLGALQPGQPLRVVATKDCEGDELENLGFASLAVGDRLEVRGSGQALGQHERDIDVLVCQRLGEPTGEEEAGEDEEVEDQEQILLPLYFSGGFVEELSDARRYSLQDLTAQFSLPCEVKVVAKDPRHPADPLPSFPGLQLEEKILEPFLVVSLDSDPEMCFEIPPRWLDLTVVEVKELPGQPSGALPMATVEELTEAFYYRLRKLPAVESQAPPPRPPKSKGLSEQKKQMSKEKGIKSSEVSELQEPPLLPKLRTKSLLKVTQDSSNLYSEVPGRKKGCRPAVPITEDSDDEHDYEEIAEQFSKTL", "length": 642, "header": "tr|A0AAA9TDF6-1|A0AAA9TDF6_BOVIN Isoform 1 of Thymocyte selection associated family member 2 OS=Bos taurus OX=9913 GN=THEMIS2 PE=3 SV=1 CANONICAL=A0AAA9TDF6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDF6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6/entry#A0AAA9TDF6-1", "sequence": { "sequence": "MEPVSLQDFVCALDPASLPRVLRVCSGVYFQGSIYEISGNECCLSTGDLIKVTHVRLQKVVCENPGTGQTTELAPNFQGLFSPLTGPQSYGTLEELVCAATQSSKSLPIRFMSTHRIATKARVVPQEQPLKLEAVEMHQGACCARCVLDSGAQQGFLHLPLSQQGPFWKLEPGPPRTLLQVLQDPTVRDTLLTCSAFPWRSLTLKPQYEVEAIMHFRRTVVKIPSTLEVDVEDVTTSSQHIHFIQPLLLSEALARGGPFPLATEILEVPQGSPNFLSPWLSSLQKGQRLCLHGVASPPWRFLASTRGRKVPRHFMISGAYRGKLRRRPREFPTAYDLLGALQPGQPLRVVATKDCEGDELENLGFASLAVGDRLEVRGSGQALGQHERDIDVLVCQRLGEPTGEEEAGEDEEVEDQEQILLPLYFSGGFVEELSDARRYSLQDLTAQFSLPCEVKVVAKDPRHPADPLPSFPGLQLEEKILEPFLVVSLDSDPEMCFEIPPRWLDLTVVEVKELPGQPSGALPMATVEELTEAFYYRLRKLPAVESQAPPPRPPKSKGLSEQKKQMSKEKGIKSSEVSELQEPPLLPKLRTKSLLKVTQDSSNLYSEVPGRKKGCRPAVPITEDSDDEHDYEEIAEQFSKTL", "length": 642, "header": "tr|A0AAA9TDF6-1|A0AAA9TDF6_BOVIN Isoform 1 of Thymocyte selection associated family member 2 OS=Bos taurus OX=9913 GN=THEMIS2 PE=3 SV=1 CANONICAL=A0AAA9TDF6-1" }, "locus": { "chromosome": "2", "start_pos": 125486064, "end_pos": 125473682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126541.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126541.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094902.1" } ] } }, { "isoform_ac": "E1BN78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6/entry#E1BN78-1", "sequence": { "sequence": "MNQIQPPPVGSFQDGREEDSRGLFSPLTGPQSYGTLEELVCAATQSSKSLPIRFMSTHRIATKARVVPQEQPLKLEAVEMHQGACCARCVLDSGAQQGFLHLPLSQQGPFWKLEPGPPRTLLQVLQDPTVRDTLLTCSAFPWRSLTLKPQYEVEAIMHFRRTVVKIPSTLEVDVEDVTTSSQHIHFIQPLLLSEALARGGPFPLATEILEVPQGSPNFLSPWLSSLQKGQRLCLHGVASPPWRFLASTRGRKVPRHFMISGAYRGKLRRRPREFPTAYDLLGALQPGQPLRVVATKDCEGDELENLGFASLAVGDRLEVRGSGQALGQHERDIDVLVCQRLGEPTGEEEAGEDEEVEDQEQILLPLYFSGGFVEELSDARRYSLQDLTAQFSLPCEVKVVAKDPRHPADPLPSFPGLQLEEKILEPFLVVSLDSDPEMCFEIPPRWLDLTVVEVKELPGQPSGALPMATVEELTEAFYYRLRKLPAVESQAPPPRPPKSKGLSEQKKQMSKEKGIKSSEVSELQEPPLLPKLRTKSLLKVTQDSSNLYSEVPGRKKGCRPAVPITEDSDDEHDYEEIAEQFSKTL", "length": 585, "header": "tr|E1BN78-1|A0AAA9TDF6_BOVIN Computationally mapped isoform of Thymocyte selection associated family member 2 OS=Bos taurus OX=9913 GN=THEMIS2 PE=3 SV=3 CANONICAL=A0AAA9TDF6-1" }, "locus": { "chromosome": "2", "start_pos": 125483002, "end_pos": 125473682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008171.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008171.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008171.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008171.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507126", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507126", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDR7-1", "protein_name": "Thymocyte selection associated family member 2", "gene_name": "Themis2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPVPLQDFASSLDPASLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHIHLEKVVCEDPETGQTLELNPNFTGLFSTLTSLQSYRTLEDLVSAMPQNSTQCPIYFKSTQRIVTEARVVPEDQPLRLEAVEVHHGTRYARCVQASKTQEIILHLPLSQKGPFWRCKPSAPQTLLQILQDPAMKGLRLTCPSLPWASVILKPQYQLQAIMHMRSSVVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLARGGPFPLSTEILEVPDGPPIFLSPWMSFLRKGQRLCIYGPASSPWRVVASSKSRKVPRYFLLSGAYQGKLKRRPREFPTAYDLLGALQPGRPLRVVATKDCDGNEEENPEFSFLAVGDRLEVLRSGQVCGAQGQDIDVLICQRLNEQSGEEEEEEEEEGEEVEDKEQVLLPLYLSGSFVEEVNDSRRYSLADLTAQYTLPCEVKVVAKDSHHPTDPLTSFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEIEGRPGQVAGPLSVPTVEELSEAFYYGLRKLPVSGNQAPPPRPPKKQQNTQRCKEGGVKARVVEPKPSCPQLERKAKTLEAFPANKSSVYSKISNKKDHKSNPQAQNSVLSMKPKSSSSLGKYSTTESHLPPDPDIDDHDYEEI", "length": 657 }, "evidence": [ { "id": "A0AAA9TDF6", "url": "https://omabrowser.org/oma/group/A0AAA9TDF6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5TEJ8-1", "protein_name": "Protein THEMIS2", "gene_name": "THEMIS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPVPLQDFVRALDPASLPRVLRVCSGVYFEGSIYEISGNECCLSTGDLIKVTQVRLQKVVCENPKTSQTMELAPNFQGYFTPLNTPQSYETLEELVSATTQSSKQLPTCFMSTHRIVTEGRVVTEDQLLMLEAVVMHLGIRSARCVLGMEGQQVILHLPLSQKGPFWTWEPSAPRTLLQVLQDPALKDLVLTCPTLPWHSLILRPQYEIQAIMHMRRTIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAWEGPFPLSMEILEVPEGRPIFLSPWVGSLQKGQRLCVYGLASPPWRVLASSKGRKVPRHFLVSGGYQGKLRRRPREFPTAYDLLGAFQPGRPLRVVATKDCEGEREENPEFTSLAVGDRLEVLGPGQAHGAQGSDVDVLVCQRLSDQAGEDEEEECKEEAESPERVLLPFHFPGSFVEEMSDSRRYSLADLTAQFSLPCEVKVVAKDTSHPTDPLTSFLGLRLEEKITEPFLVVSLDSEPGMCFEIPPRWLDLTVVKAKGQPDLPEGSLPIATVEELTDTFYYRLRKLPACEIQAPPPRPPKNQGLSKQRRHSSEGGVKSSQVLGLQQHARLPKPKAKTLPEFIKDGSSTYSKIPAHRKGHRPAKPQRQDLDDDEHDYEEILEQFQKTI", "length": 643 }, "evidence": [ { "id": "A0AAA9TDF6", "url": "https://omabrowser.org/oma/group/A0AAA9TDF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91YX0-1", "protein_name": "Protein THEMIS2", "gene_name": "Themis2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPVPLQDFVSGLDPTSLPRVLRVCSGVYFEGSVYELFGNECCLSTGDLIKVTHVQLQKVVCEYPETGQTLELNPNFTGLFSPLTSLRSYRTLEDLVSAMPQNSTRWPIYFKSTQRIVTKASVVPEDQPLRLEAVEIHHGIRYARCVQVSKTKELLHLPLSQKGPFWRCKPSAPQTLHQILQDPALKDLTLSCPSLPWNSVILKPQYMLQAIMHMRSSIVKIPSTLEVEVEDVTASSQHIHFFKPLRLSEVLAGGGPFPLTTEILEVPEGPPVFLSPWVSFLRKGQRLCIYGPASPSWRVVASSKSRKVPRYFMLSGAYQGKLKRRPREFSTAYDLLGALQPGRPLRVVATKDCDGNEEENPDFSFLAVGDRLEVLRSGQVCGTKGQDIDVLVCQRLSEQSGEEEEDLEEIEDEAEDKEQILLPLYLSGSFVEEVNDSRRYNLVDLTAQYSLPCEVKVVTKDTRHPTDPLASFPGLRLEEKLTEPFLVVSLDSQPEMCFEIPPRWLDLTVVEAEGQPAQVARPLSIAPVEELSEAFYYSLRKLPASESQAPPPRPPKSQGINKKQQNIQSCKESSVKPQVVEPQKSCPQPQLKAKTLEALPKNKSNVYSKISVHKKDRKPNPQTQNSVLSMKPKTSSSLGKHSTMESHLLPDPDMDDHDYEEI", "length": 663 }, "evidence": [ { "id": "A0AAA9TDF6", "url": "https://omabrowser.org/oma/group/A0AAA9TDF6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of B cell activation", "id": "GO:0050864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050864", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDF6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF6" }, { "id": "PF12736", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12736" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CABIT", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 237, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDI5-1", "uniprot_ac": "A0AAA9TDI5", "uniprot_id": "A0AAA9TDI5_BOVIN", "mass": { "chemical_mass": 115921.0, "monoisotopic_mass": 115921.0 }, "refseq": {}, "gene_names": [ { "name": "SIPA1", "type": "recommended", "evidence": [ { "id": "A0AAA9TDI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ] } ], "protein_names": [ { "name": "Signal-induced proliferation-associated protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TDI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#names_and_taxonomy" } ] }, { "name": "GTPase-activating protein Spa-1", "type": "synonym", "evidence": [ { "id": "A0AAA9TDI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SIPA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5", "locus": { "chromosome": "29", "start_pos": 43828086, "end_pos": 43816349, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013884", "url": "https://www.ensembl.org/id/ENSBTAG00000013884" } ] } } ], "crossref": [ { "id": "A0AAA9TDI5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDI5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013884", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013884", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06745", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06745", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MI55", "url": "https://www.orthodb.org/?gene=A0A3Q1MI55", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15711:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15711:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MI55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI55-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM17", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM17-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPCQPQCGQGRNRPAGWAPTTRARQCGPAPGEPGPQVRGAPMWAGGGVGSPRRGPAPAPTDDLFARKLRQPARPPLTPHTFEPRPTRGPLVRSGSDAGEARPPTPASPRARAHSHEEASRPAAPPARFFSDPLALLGLPAEEPEPEFPPVPEPRCFAHYDVQSLLFDWSPRPRGPGAQAEASSGTPAAAQDQTASSDLLLEAPGFVSELGGEGELGLGGPVSPPVPPSLPNAAVSVLEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKDSSGGGTLHSYRIIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHIFLVVRAEAPCTPHTSYRVAVSRTQDTPAFGPALPPGGGPFAANADFRALLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGALVWGVRAAPGARGAAGAEAGSSDGAEVPCLLGISAEALVLVAPRDGRVVFNCSCRDVLAWTFSEQRLDLYYGRGEAITLRFDGPPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAAGFITHVERFTFAETTGLRPGARLLRVCGQTVPSLGPEAAAQLLRSAPKVCVTVLPPDDSGRPRRSFSELYTLSLQEPSRRGAAEPVQDEAPAEALLPDTKQLLQVCLNDSGGPPGPGDLVEERTEFLHSQNPPSPSSSLSDEAPVLPNTTPDLLLATTAKPAAPSEGRETPLTQDGPGSPGGFEDKDEPAPELRASFLPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDAKGTPKSDAEPEPSSLSEKVSHLESMLRKLQDDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSLATDLA", "length": 1082, "header": "tr|A0AAA9TDI5-1|A0AAA9TDI5_BOVIN Isoform 1 of Signal-induced proliferation-associated protein 1 OS=Bos taurus OX=9913 GN=SIPA1 PE=4 SV=1 CANONICAL=A0AAA9TDI5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#A0A3Q1MI55-1", "sequence": { "sequence": "MWAGGGVGSPRRGPAPAPTDDLFARKLRQPARPPLTPHTFEPRPTRGPLVRSGSDAGEARPPTPASPRARAHSHEEASRPAAPPARFFSDPLALLGLPAEEPEPEFPPVPEPRCFAHYDVQSLLFDWSPRPRGPGAQAEASSGTPAAAQDQTASSDLLLEAPGFEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKDSSGGGTLHSYRIIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHIFLVVRAEAPCTPHTSYRVAVSRTQDTPAFGPALPPGGGPFAANADFRALLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGALVWGVRAAPGARGAAGAEAGSSDGAEVPCLLGISAEALVLVAPRDGRVVFNCSCRDVLAWTFSEQRLDLYYGRGEAITLRFDGPPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAAGFITHVERFTFAETTGLRPGARLLRVCGQTVPSLGPEAAAQLLRSAPKVCVTVLPPDDSGRPRRSFSELYTLSLQEPSRRGAAEPVQDEAPAEALLPDTKQLLQVCLNDSGGPPGPGDLVEERTEFLHSQNPPSPSSSLSDEAPVLPNTTPDLLLATTAKPAAPSEGRETPLTQDGPGSPGGFEDKDEPAPELRASFLPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDAKGTPKSDAEPEPSSLSEKVSHLESMLRKLQDDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSLATDLA", "length": 1008, "header": "tr|A0A3Q1MI55-1|A0A3Q1MI55_BOVIN Computationally mapped isoform of Signal-induced proliferation-associated protein 1 OS=Bos taurus OX=9913 GN=SIPA1 PE=4 SV=2 CANONICAL=A0AAA9TDI5-1" }, "locus": { "chromosome": "29", "start_pos": 43827849, "end_pos": 43818930, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066483.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066483.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068819.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068819.2" } ] } }, { "isoform_ac": "A0AAA9TDI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#A0AAA9TDI5-1", "sequence": { "sequence": "MPCQPQCGQGRNRPAGWAPTTRARQCGPAPGEPGPQVRGAPMWAGGGVGSPRRGPAPAPTDDLFARKLRQPARPPLTPHTFEPRPTRGPLVRSGSDAGEARPPTPASPRARAHSHEEASRPAAPPARFFSDPLALLGLPAEEPEPEFPPVPEPRCFAHYDVQSLLFDWSPRPRGPGAQAEASSGTPAAAQDQTASSDLLLEAPGFVSELGGEGELGLGGPVSPPVPPSLPNAAVSVLEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKDSSGGGTLHSYRIIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHIFLVVRAEAPCTPHTSYRVAVSRTQDTPAFGPALPPGGGPFAANADFRALLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGALVWGVRAAPGARGAAGAEAGSSDGAEVPCLLGISAEALVLVAPRDGRVVFNCSCRDVLAWTFSEQRLDLYYGRGEAITLRFDGPPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAAGFITHVERFTFAETTGLRPGARLLRVCGQTVPSLGPEAAAQLLRSAPKVCVTVLPPDDSGRPRRSFSELYTLSLQEPSRRGAAEPVQDEAPAEALLPDTKQLLQVCLNDSGGPPGPGDLVEERTEFLHSQNPPSPSSSLSDEAPVLPNTTPDLLLATTAKPAAPSEGRETPLTQDGPGSPGGFEDKDEPAPELRASFLPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDAKGTPKSDAEPEPSSLSEKVSHLESMLRKLQDDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSLATDLA", "length": 1082, "header": "tr|A0AAA9TDI5-1|A0AAA9TDI5_BOVIN Isoform 1 of Signal-induced proliferation-associated protein 1 OS=Bos taurus OX=9913 GN=SIPA1 PE=4 SV=1 CANONICAL=A0AAA9TDI5-1" }, "locus": { "chromosome": "29", "start_pos": 43827849, "end_pos": 43817972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113278.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113278.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094198.1" } ] } }, { "isoform_ac": "A0AAA9TSL0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#A0AAA9TSL0-1", "sequence": { "sequence": "APMWAGGGVGSPRRGPAPAPTDDLFARKLRQPARPPLTPHTFEPRPTRGPLVRSGSDAGEARPPTPASPRARAHSHEEASRPAAPPARFFSDPLALLGLPAEEPEPEFPPVPEPRCFAHYDVQSLLFDWSPRPRGPGAQAEASSGTPAAAQDQTASSDLLLEAPGFVSELGGEGELGLGGPVSPPVPPSLPNAAVSVLEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKDSSGGGTLHSYRIIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHIFLVVRAEAPCTPHTSYRVAVSRTQDTPAFGPALPPGGGPFAANADFRALLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNERLDLYYGRGEAITLRFDGPPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAAGFITHVERFTFAETTGLRPGARLLRVCGQTVPSLGPEAAAQLLRSAPKVCVTVLPPDDSGRPRRSFSELYTLSLQEPSRRGAAEPVQDEAPAEALLPDTKQLLQVCLNDSGGPPGPGDLVEERTEFLHSQNPPSPSSSLSDEAPVLPNTTPDLLLATTAKPAAPSEGRETPLTQDGPGSPGGFEDKDEPAPELRASFLPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDAKGTPKSDAEPEPSSLSEKVSHLESMLRKLQDDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSLATDLA", "length": 941, "header": "tr|A0AAA9TSL0-1|A0AAA9TSL0_BOVIN Computationally mapped isoform of Signal-induced proliferation-associated protein 1 OS=Bos taurus OX=9913 GN=SIPA1 PE=4 SV=1 CANONICAL=A0AAA9TDI5-1" }, "locus": { "chromosome": "29", "start_pos": 43827849, "end_pos": 43818924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105133.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105133.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100343.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100343.1" } ] } }, { "isoform_ac": "A0AAF6DM17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5/entry#A0AAF6DM17-1", "sequence": { "sequence": "MGRNRPAGWAPTTRARQCGPAPGEPGPQVRGAPMWAGGGVGSPRRGPAPAPTDDLFARKLRQPARPPLTPHTFEPRPTRGPLVRSGSDAGEARPPTPASPRARAHSHEEASRPAAPPARFFSDPLALLGLPAEEPEPEFPPVPEPRCFAHYDVQSLLFDWSPRPRGPGAQAEASSGTPAAAQDQTASSDLLLEAPGFVSELGGEGELGLGGPVSPPVPPSLPNAAVSVLEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKDSSGGGTLHSYRIIVRTTQLRTLRGTISEDALPPGPPRGLSPRKLLEHVAPRLSPTCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHIFLVVRAEAPCTPHTSYRVAVSRTQDTPAFGPALPPGGGPFAANADFRALLLAKALNGEQAAGHARQFHAMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRAAPRGPGAELQAAGALVWGVRAAPGARGAAGAEAGSSDGAEVPCLLGISAEALVLVAPRDGRVVFNCSCRDVLAWTFSEQRLDLYYGRGEAITLRFDGPPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAAGFITHVERFTFAETTGLRPGARLLRVCGQTVPSLGPEAAAQLLRSAPKVCVTVLPPDDSGRPRRSFSELYTLSLQEPSRRGAAEPVQDEAPAEALLPDTKQLLQVCLNDSGGPPGPGDLVEERTEFLHSQNPPSPSSSLSDEAPVLPNTTPDLLLATTAKPAAPSEGRETPLTQDGPGSPGGFEDKDEPAPELRASFLPRTLSLRNSISKIMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPILESGDAKGTPKSDAEPEPSSLSEKVSHLESMLRKLQDDLQKEKADRAALEEEVRSLRHNNRRLQAESESAATRLLLASKQLGSLATDLA", "length": 1074, "header": "tr|A0AAF6DM17-1|A0AAF6DM17_BOVIN Computationally mapped isoform of Signal-induced proliferation-associated protein 1 OS=Bos taurus OX=9913 GN=SIPA1 PE=4 SV=1 CANONICAL=A0AAA9TDI5-1" }, "locus": { "chromosome": "29", "start_pos": 43827849, "end_pos": 43818727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018435.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018435.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018435.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018435.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 104, "start_aa": "Thr", "end_pos": 104, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr104", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 185, "start_aa": "Thr", "end_pos": 185, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr185", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of small GTPase mediated signal 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"MPVTGKTFRRRRADSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRI", "length": 289, "header": "tr|A0AAA9TDL0-1|A0AAA9TDL0_BOVIN Isoform 1 of Chromosome 11 C9orf78 homolog OS=Bos taurus OX=9913 GN=C11H9orf78 PE=3 SV=1 CANONICAL=A0AAA9TDL0-1" }, "locus": { "chromosome": "11", "start_pos": 100214762, "end_pos": 100205815, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103466.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103466.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096713.1" } ] } }, { "isoform_ac": "A0AAA9TI25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0/entry#A0AAA9TI25-1", "sequence": { "sequence": "MPVTGKTFRRRRADSESEEDEQDSEEVRAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY", "length": 269, "header": "tr|A0AAA9TI25-1|A0AAA9TI25_BOVIN Computationally mapped isoform of Chromosome 11 C9orf78 homolog OS=Bos taurus OX=9913 GN=C11H9orf78 PE=3 SV=1 CANONICAL=A0AAA9TDL0-1" }, "locus": { "chromosome": "11", "start_pos": 100214762, "end_pos": 100206831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115230.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115230.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097926.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097926.1" } ] } }, { "isoform_ac": "A0AAA9TYF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0/entry#A0AAA9TYF0-1", "sequence": { "sequence": "MPVTGKTFRRRRADSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY", "length": 289, "header": "tr|A0AAA9TYF0-1|A0AAA9TYF0_BOVIN Computationally mapped isoform of Chromosome 11 C9orf78 homolog OS=Bos taurus OX=9913 GN=C11H9orf78 PE=3 SV=1 CANONICAL=A0AAA9TDL0-1" }, "locus": { "chromosome": "11", "start_pos": 100214762, "end_pos": 100206831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090511.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090511.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102253.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102253.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of homologous chromosome segregation", "id": "GO:0060629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" }, { "name": "mRNA cis splicing, via spliceosome", "id": "GO:0045292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045292", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "U5 snRNA binding", "id": "GO:0030623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030623", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDL1-1", "uniprot_ac": "A0AAA9TDL1", "uniprot_id": "A0AAA9TDL1_BOVIN", "mass": { "chemical_mass": 55312.0, "monoisotopic_mass": 55312.0 }, "refseq": {}, "gene_names": [ { "name": "SBK1", "type": "recommended", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase SBK1", "type": "recommended", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1/entry#names_and_taxonomy" } ] }, { "name": "SH3 domain-binding kinase 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in signal-transduction pathways related to the control of brain development.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1#function" }, { "database": "UniProtKB", "id": "ARBA00058173", "url": "https://www.uniprot.org/uniprotkb/ARBA00058173#function" }, { "database": "UniProtKB", "id": "F1MX36", "url": "https://www.uniprot.org/uniprotkb/F1MX36#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SBK1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1", "locus": { "chromosome": "25", "start_pos": 25821461, "end_pos": 25769711, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032140", "url": "https://www.ensembl.org/id/ENSBTAG00000032140" } ] } } ], "crossref": [ { "id": "A0AAA9TDL1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032140", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032140", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13987", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13987", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614815", "url": "https://www.ncbi.nlm.nih.gov/gene/614815", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614815", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614815", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IFCFIKY", "url": "https://omabrowser.org/oma/group/IFCFIKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MX36", "url": "https://www.orthodb.org/?gene=F1MX36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24359", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24359", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24359:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24359:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX36", "url": "https://www.uniprot.org/uniprotkb/F1MX36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MX36-1", "url": "https://www.uniprot.org/uniprotkb/F1MX36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KAQVAGGQAQAQGPEANRLLTLEHAGSGSPAQARDDAVEAATSHPCPVLELPPAWPLRCGKEDVPAFCFVCFHREEEEELLEEVPLQREKMSVGCPEPEPPHSLPCCGPGTAPGLGAGVPLLTEDMQALTLRTVAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPAGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGPGPVPVPVPVPVPEPGLAPPGPPGRTDGRPDKSKGQVVLATAIEICV", "length": 508, "header": "tr|A0AAA9TDL1-1|A0AAA9TDL1_BOVIN Isoform 1 of Serine/threonine-protein kinase SBK1 OS=Bos taurus OX=9913 GN=SBK1 PE=4 SV=1 CANONICAL=A0AAA9TDL1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1/entry#A0AAA9TDL1-1", "sequence": { "sequence": "KAQVAGGQAQAQGPEANRLLTLEHAGSGSPAQARDDAVEAATSHPCPVLELPPAWPLRCGKEDVPAFCFVCFHREEEEELLEEVPLQREKMSVGCPEPEPPHSLPCCGPGTAPGLGAGVPLLTEDMQALTLRTVAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPAGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGPGPVPVPVPVPVPEPGLAPPGPPGRTDGRPDKSKGQVVLATAIEICV", "length": 508, "header": "tr|A0AAA9TDL1-1|A0AAA9TDL1_BOVIN Isoform 1 of Serine/threonine-protein kinase SBK1 OS=Bos taurus OX=9913 GN=SBK1 PE=4 SV=1 CANONICAL=A0AAA9TDL1-1" }, "locus": { "chromosome": "25", "start_pos": 25820457, "end_pos": 25769711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092197.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092197.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096214.1" } ] } }, { "isoform_ac": "F1MX36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1/entry#F1MX36-1", "sequence": { "sequence": "MSVGCPEPEPPHSLPCCGPGTAPGLGAGVPLLTEDMQALTLRTVAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPAGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGPGPVPVPVPVPVPEPGLAPPGPPGRTDGRPDKSKGQVVLATAIEICV", "length": 418, "header": "tr|F1MX36-1|F1MX36_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase SBK1 OS=Bos taurus OX=9913 GN=SBK1 PE=3 SV=3 CANONICAL=A0AAA9TDL1-1" }, "locus": { "chromosome": "25", "start_pos": 25820457, "end_pos": 25816381, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045600.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045600.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042978.4", "url": "https://www.ensembl.org/id/ENSBTAP00000042978.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614815", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614815", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4F952-1", "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "SBK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "KAQVAGGQVRGPEANRLLTLEHTGSGTPAQARDDAAEATTSHPCPVLELPPAWPLGCGVEDVPAFCFVCFHREEEEELLEEVPLQREKMSVGVPEPEPPHSLPCCGPGTAPGLGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPAGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGPVPVPVPVPVPEPGLAPPGPPGRTDGRPDKSKGQVVLATAIEICV", "length": 504 }, "evidence": [ { "id": "A0AAA9TDL1", "url": "https://omabrowser.org/oma/group/A0AAA9TDL1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q52WX2-1", "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "SBK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAIEICV", "length": 424 }, "evidence": [ { "id": "A0AAA9TDL1", "url": "https://omabrowser.org/oma/group/A0AAA9TDL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8QZX0-1", "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "Sbk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVGCPEPEPLHSLPCCGPGAAPVPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEECYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHSRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRLPGSLRLEAPGPLKRTVLTESGSGSRPSPPSVGPVVPVPVPVPVPVPEAGLAPPAPPGRTDGRTDKSKGQVVLATAIEICV", "length": 417 }, "evidence": [ { "id": "A0AAA9TDL1", "url": "https://omabrowser.org/oma/group/A0AAA9TDL1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Z335-1", "protein_name": "Serine/threonine-protein kinase SBK1", "gene_name": "Sbk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVGCPEPEPLHSLPCCGPGAAPVPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEECYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHSRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRLPGPLRLEAPGPLKRTVLTESGSGSRPSPPSVGPVVPVPVPVPVPVPEAGLAPPAPPGRTDGRADKSKGQVVLATAIEICV", "length": 417 }, "evidence": [ { "id": "A0AAA9TDL1", "url": "https://omabrowser.org/oma/group/A0AAA9TDL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ], "pmid": "" }, { "name": "protein serine kinase activity", "id": "GO:0106310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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"uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", 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OS=Bos taurus OX=9913 GN=PATL2 PE=3 SV=3 CANONICAL=A0AAA9TDV4-1" }, "locus": { "chromosome": "10", "start_pos": 103068910, "end_pos": 103060244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002039.4", "url": "https://www.ensembl.org/id/ENSBTAT00000002039.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002039.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002039.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3, "start_aa": "Thr", "end_pos": 3, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "deadenylation-dependent decapping of nuclear-transcribed mRNA", "id": "GO:0000290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000290", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" } ], "pmid": "" }, { "name": "P-body assembly", "id": "GO:0033962", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033962", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" } ], "pmid": "" }, { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV4" }, { "id": "PF09770", 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"categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TVENQSSVSEFLLLGIPIQSEQQGVFFALFLGMYLTTVLGNLLILLLIRLDSRLHNPMYFFLSHLALTDITFSSVTVPKMLVIMQTKRKSIPYAGCLSQTCFFILLADLDSFLITTMAYDRYVAICHPLHYTTIMSQSVCVTLVLGSWVIACACALLHTLLLAQLSFCADNTIPYFFCDLAALLKLSCSDTSLNQLVIFTAGLTAIMLPFVCILVSYGHIGATILRVPSAKGICKALSTCGSHLSVVTLYYGAIIGVYFLPSSNSTNDSNIISSLMYTVVTPMLNPFIYSLR", "length": 292, "header": "tr|A0AAA9TDV9-1|A0AAA9TDV9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9TDV9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDV9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9/entry#A0AAA9TDV9-1", "sequence": { "sequence": "TVENQSSVSEFLLLGIPIQSEQQGVFFALFLGMYLTTVLGNLLILLLIRLDSRLHNPMYFFLSHLALTDITFSSVTVPKMLVIMQTKRKSIPYAGCLSQTCFFILLADLDSFLITTMAYDRYVAICHPLHYTTIMSQSVCVTLVLGSWVIACACALLHTLLLAQLSFCADNTIPYFFCDLAALLKLSCSDTSLNQLVIFTAGLTAIMLPFVCILVSYGHIGATILRVPSAKGICKALSTCGSHLSVVTLYYGAIIGVYFLPSSNSTNDSNIISSLMYTVVTPMLNPFIYSLR", "length": 292, "header": "tr|A0AAA9TDV9-1|A0AAA9TDV9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0AAA9TDV9-1" }, "locus": { "chromosome": "11", "start_pos": 93592360, "end_pos": 93591485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099175.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099175.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095086.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDV9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 }, { "start_pos": 267, "end_pos": 269 }, { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAX0-1", "uniprot_ac": "A0AAA9TAX0", "uniprot_id": "A0AAA9TAX0_BOVIN", "mass": { "chemical_mass": 102287.0, "monoisotopic_mass": 102287.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC39", "type": "recommended", "evidence": [ { "id": "A0AAA9TAX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ] } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 39", "type": "recommended", "evidence": [ { "id": "A0AAA9TAX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.", "evidence": [ { "database": "UniProtKB", "id": "G5E519", "url": "https://www.uniprot.org/uniprotkb/G5E519#function" }, { "database": "UniProtKB", "id": "ARBA00045182", "url": "https://www.uniprot.org/uniprotkb/ARBA00045182#function" }, { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0", "locus": { "chromosome": "1", "start_pos": 86371093, "end_pos": 86318639, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001969", "url": "https://www.ensembl.org/id/ENSBTAG00000001969" } ] } } ], "crossref": [ { "id": "A0AAA9TAX0", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TAX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001969", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001969", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534432", "url": "https://www.ncbi.nlm.nih.gov/gene/534432", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR033290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534432", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534432", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSKNCDE", "url": "https://omabrowser.org/oma/group/NSKNCDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "G5E519", "url": "https://www.orthodb.org/?gene=G5E519", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18962", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18962", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18962:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18962:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00009fqr", "url": "https://www.rcsb.org/structure/pdb_00009fqr", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "9FQR", "url": "https://www.rcsb.org/structure/9FQR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF24161", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24161", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E519", "url": "https://www.uniprot.org/uniprotkb/G5E519", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G5E519-1", "url": "https://www.uniprot.org/uniprotkb/G5E519-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSEFLAELRWEDGFAIPVANEENKTLEEQLSKLQDERSSMQDQLRDYEDRINAMTSHFKNVKQEFLFTQSLCKARDHEIESEEHFKMIAERELGRVKDEIQRLENEITSIREKKNDKENSIFKTTQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTVECNQRRKVLDNEFAETLSVQLELDKAAQDFRKIHNERQKLILQWESTIEQMQKRDKDIDNCAVLDSLKATVNRSSSDLEALRKNISKVKMDINEETARLGKIKNHNQIVRKKLKEITEKTMSVEEKATNLEDMLREEERGVKEVEVQLNIVKDVLFKKVQELQTETMKEKALVSEIEGTRSSLKHLNHQLHKLDFETLQQQEIMYAQDFYIQQVERRMSRLKGDINSEEKQALEAKTVELQKTLEEKKSALCLLETQIKKLHNDLYFTKKSNSKYRDEKQSLMTKINELTLFNDRSEKELTKAKALKQDLMIEDNLLKLEVKRTRELLHSKAEEVLSLEKRKQQLHTAMEERTEEIKVHKTMLASQIRYVDQERQNISAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALGNTLQVLNSCNNNYKQSFQKVTPSSAEYEVKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLTVIEHLTNNVKEKVTEKQAYVLQLNRETEEQKPKLERVTKQCAKLTKEVRLLKDTKDETLEEQDIKLREVKQLHKIIDEMIVDITQENAEIGVILQTYFQQSGLELPTTSTKGSRHSSRSPSQTSLLSARSSKSTSTSASQTSIKVLELNFPASPLTGSTSRPTSASSASSTGKSRKTNK", "length": 877, "header": "tr|A0AAA9TAX0-1|A0AAA9TAX0_BOVIN Isoform 1 of Coiled-coil domain-containing protein 39 OS=Bos taurus OX=9913 GN=CCDC39 PE=3 SV=1 CANONICAL=A0AAA9TAX0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0/entry#A0AAA9TAX0-1", "sequence": { "sequence": "MSSEFLAELRWEDGFAIPVANEENKTLEEQLSKLQDERSSMQDQLRDYEDRINAMTSHFKNVKQEFLFTQSLCKARDHEIESEEHFKMIAERELGRVKDEIQRLENEITSIREKKNDKENSIFKTTQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTVECNQRRKVLDNEFAETLSVQLELDKAAQDFRKIHNERQKLILQWESTIEQMQKRDKDIDNCAVLDSLKATVNRSSSDLEALRKNISKVKMDINEETARLGKIKNHNQIVRKKLKEITEKTMSVEEKATNLEDMLREEERGVKEVEVQLNIVKDVLFKKVQELQTETMKEKALVSEIEGTRSSLKHLNHQLHKLDFETLQQQEIMYAQDFYIQQVERRMSRLKGDINSEEKQALEAKTVELQKTLEEKKSALCLLETQIKKLHNDLYFTKKSNSKYRDEKQSLMTKINELTLFNDRSEKELTKAKALKQDLMIEDNLLKLEVKRTRELLHSKAEEVLSLEKRKQQLHTAMEERTEEIKVHKTMLASQIRYVDQERQNISAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALGNTLQVLNSCNNNYKQSFQKVTPSSAEYEVKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLTVIEHLTNNVKEKVTEKQAYVLQLNRETEEQKPKLERVTKQCAKLTKEVRLLKDTKDETLEEQDIKLREVKQLHKIIDEMIVDITQENAEIGVILQTYFQQSGLELPTTSTKGSRHSSRSPSQTSLLSARSSKSTSTSASQTSIKVLELNFPASPLTGSTSRPTSASSASSTGKSRKTNK", "length": 877, "header": "tr|A0AAA9TAX0-1|A0AAA9TAX0_BOVIN Isoform 1 of Coiled-coil domain-containing protein 39 OS=Bos taurus OX=9913 GN=CCDC39 PE=3 SV=1 CANONICAL=A0AAA9TAX0-1" }, "locus": { "chromosome": "1", "start_pos": 86370330, "end_pos": 86318896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113954.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113954.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093173.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093173.1" } ] } }, { "isoform_ac": "G5E519-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0/entry#G5E519-1", "sequence": { "sequence": "MSSEFLAELRWEDGFAIPVANEENKTLEEQLSKLQDERSSMQDQLRDYEDRINAMTSHFKNVKQEFLFTQSLCKARDHEIESEEHFKMIAERELGRVKDEIQRLENEITSIREKKNDKENSIFKTTQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTVECNQRRKVLDNEFAETLSVQLELDKAAQDFRKIHNERQKLILQWESTIEQMQKRDKDIDNCAVALARIKQEIREKENLVKEKIKFLENEIGNNTEYEKKISVADRKVLKCRTEYQRHEANRIQLKDELDSLKATVNRSSSDLEALRKNISKVKMDINEETARLGKIKNHNQIVRKKLKEITEKTMSVEEKATNLEDMLREEERGVKEVEVQLNIVKDVLFKKVQELQTETMKEKALVSEIEGTRSSLKHLNHQLHKLDFETLQQQEIMYAQDFYIQQVERRMSRLKGDINSEEKQALEAKTVELQKTLEEKKSALCLLETQIKKLHNDLYFTKKSNSKYRDEKQSLMTKINELTLFNDRSEKELTKAKALKQDLMIEDNLLKLEVKRTRELLHSKAEEVLSLEKRKQQLHTAMEERTEEIKVHKTMLASQIRYVDQERQNISAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALGNTLQVLNSCNNNYKQSFQKVTPSSAEYEVKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLTVIEHLTNNVKEKVTEKQAYVLQLNRETEEQKPKLERVTKQCAKLTKEVRLLKDTKDETLEEQDIKLREVKQLHKIIDEMIVDITQENAEIGVILQTYFQQSGLELPTTSTKGSRHSSRSPSQTSLLSARSSKSTSTSASQTSIKVLELNFPASPLTGSTSRPTSASSASSTGKSRKTNK", "length": 941, "header": "tr|G5E519-1|G5E519_BOVIN Computationally mapped isoform of Coiled-coil domain-containing protein 39 OS=Bos taurus OX=9913 GN=CCDC39 PE=1 SV=2 CANONICAL=A0AAA9TAX0-1" }, "locus": { "chromosome": "1", "start_pos": 86370330, "end_pos": 86318896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002557.8", "url": "https://www.ensembl.org/id/ENSBTAT00000002557.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002557.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002557.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "G5E519", "url": "https://www.uniprot.org/uniprotkb/G5E519" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:534432", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534432", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061IPR2-1", "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "Ccdc39", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSEFLSELHWEDGFAIPVANQENKMLEDQLSKLQKEKSNLQDQLRDYEDRINSMTSHFKNVNQEFSFTQALYKAREYEIESEEHFKAIAERELGRVKDEIQRLEKEMTAIRERKNDTENAIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDTFTLQKYAQQDDNKIRALTLQLERLTVECNEKRKLLDNELTETLSVQLELDKAAQDFRKIHLERQELIQQWESTIEQMKRRDQEIDNFALTLSRIKQETREKEGLVKEKIKFLENEVGNNVEYERRISAAERKVLKFRMEYQRHETSRTQLKDELDTLKATLNRTSSDLEALRKNISKVKKDIHDETSKLQKLKRHNEVVKHKLNMITEKTMSVEEKATNMEDMLKEEEKSVREVEVQLNIVKDVLFKKVQELQNETMKEKALVSEIEGTRCALKHLNHRLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQSLETKIVELKKTLDEKKSTLSLLEAQIKKLHNDLYFLKKSNSKNNDEKQSVMNKINELHLFVDRSEKELNKAITAKQDLMIDDNLLKLEVKRTRELLYSKAEEVLSLEKRKQQLYTTMKERAEEIKVHKAMLASQIKYVDQQRQTVSFEFQERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALQNTLQVLNSCNNNYKQSFKKVTPSSDEYGMKIQLEEQKRSADEKYRCRQRQIRELQEDIQSMENTFEVLEHLANNVKEKLTEKQSYSLQLSKETEEQLPKLERVTKQCGRLKREIRILKETNDETLEEQDIELREIKQYHRDIDQMLVTIMEDTEVNIILQTYFEQNGLELPAVKGQSSRSSSQSSLSSVRSPEVPVTPVVPVTPVSPTSVKVLQQSLPESPTGSNSSRSASNGSNSSTPKGKKPSK", "length": 942 }, "evidence": [ { "id": "A0AAA9TAX0", "url": "https://omabrowser.org/oma/group/A0AAA9TAX0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A5G2QJI8-1", "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "CCDC39", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSEFLAELHWEDGFAIPVANEENKILEDQLSKLQNERSSLQDQLRDYEDRINAMTSHFKNVKQEFLFTQSLCKAREHEIESEEHFKMIAERELGRVKDEIQRLENETASIQEKKSDKENYIFKTIQKLDGLKCQMNWDQQALEAWLEESARKDSDAFTLQKYAQQDDNKIRALTLQLERLTVECNQRRKVLDNELAETLSAQLELDKAAQDFRKIHSERQELIKQWENTIEQMQQRDRDIDNCALLDSLKATVNRSSSDLEALRKNISKIKKDINEETTRLHKIKNHNQIVRKKLKQITEKTMSVEEKATNLEDMLKEEERGVKEVEVQLNILKDVLFKKVRELQTETMKEKAIVSEIEGTRSSLKHLNHQLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEERQALEAKTVELKKTLEEKKSTLSLLEVQIKKLHNDLYFIKKSNSKNCDEKQSLMTKINELNLFNDRSEKELNKVKALKQDLMIEDNLLKLEVKRAREMLHSKAKEVLSLEKRKQQLHTAMEERTEEIKVHKTMLASQIRYVDQERQNVSAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALGNTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLAVIEHVTNNVKEKMSEKQAYALQLSRETEEQKPKLERVTKQCAKLTKEIRLLKDTKDVTLEEHDIKLREVKRLHKIIDEMLADIAEENAEIGTILQTYFQQSGLELPTASTKGSHHSSRSPSQTSLLSSARSSKSTSTSTSQTSIKVLELNFPASPLIGSTSRPASVSSGSSNGKSKKSNK", "length": 878 }, "evidence": [ { "id": "A0AAA9TAX0", "url": "https://omabrowser.org/oma/group/A0AAA9TAX0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3Z8K2-1", "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "Ccdc39", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSEFLSELHWEDGFAIPVANQENKILEDQLAKLHKEKSNLQDQLRDYEDRINSMSSHLKNVNQEFLFTQSLYKARECEIESEEHFKAIAERELGRVKDEIQQLEKEMAIILERKNDKENAIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDNNKIRALTLKLEKLTMECNEKRKLLDNELTETLSAQLELDKAAQDFRKIHVERQELIQQWENTIEQMQRRDQEIDNCALALARIKQEAREKEGVVREKIKFLENEVGNNVEYERRISIAERKVSKCRMEYQRQEANRNQLKDELDTLKTTLNRTSSDLEALRKNISKVKKDILDETGRLQKLKHHNEIVKHKLKMITEKTISIEEKATNMEDMLKEEEKNLKEVEVQLNIVKGVLFKKVQELQSAITKEKALGSEIEGTRSSLKHLNQRLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALEVKIVELRKTMEERKSTLSLLEEQIKKLHNDLYFIKKSNGKNKDEKESLMNKIGELHLFVDRSEKELNKAKAVKEDLMIEDNLLKLQVKRARELLYSKAEEVLSLEKRKQQLCTAMEERVEEIKVHKAMLTSQIRYVDQQRQTVSSEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKISKAEKEIYALQNTLQVLSSCNNNYKQSFKKVTPSSDEYGIKIQLEEQKRSADEKYRCKQRQIRELQEDIQSMENTFEVIEHLANNAREKLSEKQTLSFQLRKETEEQKPKIQRVTKQCGRLRREIRILRQTNDETLEEQDIQLREIIQFHKDIDQMLVNAMENAEIHVIFQTYFQQNGLELPTAKGPSSRSSSQSSLSSIRSLEDSIPISPPTAKVIELRFPGPPARSDSSRSSSGSNSNIPKGKKLNK", "length": 934 }, "evidence": [ { "id": "A0AAA9TAX0", "url": "https://omabrowser.org/oma/group/A0AAA9TAX0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D5Y1-1", "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "Ccdc39", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCSEFLSELHWEDGFAIPVANQENKILEDQLAKLREEKSNLQDQLHDYEERINSMTSHLKNVNQEFLFTQSLYKARESEIESEEHFKAIAERELGRVKNETQLLEKEMAIIRERKSQMENNIFKTTQKLDDLKCQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDDNKIRALTLQLEKLTMEYNEKRKLLDSELTETLSAQLELDKAAQDFRKIHLERQELIQQWENTIEQMQRRDQEIDNCALALSRIKQEAREKEGVVKEKIKFLENEVENNIEYERKISVAERKVSKCRMDYQRHEGNRSQLKDELDTLKTTLNRTSSDLQALRKNISKVKKDIFDETLRLQKLKHHNEVVKHKLKMITEKTLSIEEKATNMEDMLKEEEKGLKEVEVQLGIVKDVLFKKVQELQNEIAKEKALVSEIEGTRSSLKHLNKQLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALEAKILELKKTMDEKKSTLSLLESQIKKLHNDLYFIKKSNGKNNDEKESLMNKISELNLFIDRSEKELSKAKAVKEDMMIEDNLLKLQVKRARELLYSKAEEVLSLEKRKQQLGKDMEERAEEIKVHKAMLTSQIRCVEQQRKTMSSEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALQNTLQVLNSCNSNYKQSFKKVTPSSDEYALKIQLEEQKRTADERYRCKQRQIRELQEDIQSMENTFEVIGHLANNAKEKLTEKQTLAFQLRKETEEQKPKLQRITKQCGRLRREIRILKQTDNETLEEQDIQLREIIQFHKDIDQMLVNAMENAEIHAIFKTYFEQNGLELPTARGPSSRSSSQSSSLSSFRSLEDVTLQSPPTAKVIQLRFPEPPPATNDSSRSASSGSNSNIPKEKKLSK", "length": 937 }, "evidence": [ { "id": "A0AAA9TAX0", "url": "https://omabrowser.org/oma/group/A0AAA9TAX0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UFE4-1", "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "CCDC39", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK", "length": 941 }, "evidence": [ { "id": "A0AAA9TAX0", "url": "https://omabrowser.org/oma/group/A0AAA9TAX0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "inner dynein arm assembly", "id": "GO:0036159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036159", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "lung development", "id": "GO:0030324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030324", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "heart looping", "id": "GO:0001947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001947", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "determination of pancreatic left/right asymmetry", "id": "GO:0035469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035469", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "cilium-dependent cell motility", "id": "GO:0060285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060285", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "epithelial cilium movement involved in determination of left/right asymmetry", "id": "GO:0060287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060287", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "determination of digestive tract left/right asymmetry", "id": "GO:0071907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071907", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" }, { "name": "determination of liver left/right asymmetry", "id": "GO:0071910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071910", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": 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"Bos taurus [9913]" } ], "gene": [ { "name": "SOX5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3", "locus": { "chromosome": "5", "start_pos": 86627007, "end_pos": 85672952, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022360", "url": "https://www.ensembl.org/id/ENSBTAG00000022360" } ] } } ], "crossref": [ { "id": "A0AAA9TDU3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TDU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022360", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022360", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22030", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22030", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22042", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22042", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533829", "url": "https://www.ncbi.nlm.nih.gov/gene/533829", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036910", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQ49", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR44", "url": "https://www.orthodb.org/?gene=A0A3Q1MR44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWN9", "url": "https://www.orthodb.org/?gene=A0A3Q1MWN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45789", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45789", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45789:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45789:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847670", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847670", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR44", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR44-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWN9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWN9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMD2", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DMD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMD2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 751, "header": "tr|A0AAA9TDU3-1|A0AAA9TDU3_BOVIN Isoform 1 of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=1 CANONICAL=A0AAA9TDU3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0A3Q1LQ49-1", "sequence": { "sequence": "MKQSPNMRMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 724, "header": "tr|A0A3Q1LQ49-1|A0AAA9TDU3_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=2 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86081205, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078881.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078881.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057086.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057086.2" } ] } }, { "isoform_ac": "A0A3Q1MR44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0A3Q1MR44-1", "sequence": { "sequence": "VSVMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 753, "header": "tr|A0A3Q1MR44-1|A0A3Q1MR44_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=2 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86159664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073558.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073558.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074161.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074161.2" } ] } }, { "isoform_ac": "A0A3Q1MWN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0A3Q1MWN9-1", "sequence": { "sequence": "MRVCVQLETIIGGCCDKGKLCFSSMLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 787, "header": "tr|A0A3Q1MWN9-1|A0A3Q1MWN9_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=2 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86159660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077774.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077774.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059948.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059948.2" } ] } }, { "isoform_ac": "A0AAA9SP99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0AAA9SP99-1", "sequence": { "sequence": "MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 642, "header": "tr|A0AAA9SP99-1|A0AAA9TDU3_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=1 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86219341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117201.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117201.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084723.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084723.1" } ] } }, { "isoform_ac": "A0AAA9SPZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0AAA9SPZ7-1", "sequence": { "sequence": "MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 722, "header": "tr|A0AAA9SPZ7-1|A0AAA9TDU3_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=2 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86219341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112535.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112535.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087446.2", "url": "https://www.ensembl.org/id/ENSBTAP00000087446.2" } ] } }, { "isoform_ac": "A0AAA9TDU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0AAA9TDU3-1", "sequence": { "sequence": "MSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPASQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTTLGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGVPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 751, "header": "tr|A0AAA9TDU3-1|A0AAA9TDU3_BOVIN Isoform 1 of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=1 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86219341, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129053.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129053.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094938.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094938.1" } ] } }, { "isoform_ac": "A0AAF6DMD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3/entry#A0AAF6DMD2-1", "sequence": { "sequence": "MHDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPASLASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN", "length": 377, "header": "tr|A0AAF6DMD2-1|A0AAF6DMD2_BOVIN Computationally mapped isoform of SRY-box transcription factor 5 OS=Bos taurus OX=9913 GN=SOX5 PE=4 SV=2 CANONICAL=A0AAA9TDU3-1" }, "locus": { "chromosome": "5", "start_pos": 86626479, "end_pos": 86563149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030260.7", "url": "https://www.ensembl.org/id/ENSBTAT00000030260.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030245.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030245.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 318, "start_aa": "Thr", "end_pos": 318, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr318", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": 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"MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 380, "header": "tr|A0AAA9TCV6-1|A0AAA9TCV6_BOVIN Isoform 1 of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=1 CANONICAL=A0AAA9TCV6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPA8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1LPA8-1", "sequence": { "sequence": "MAEGAQPQQPPQLGPGAAARGMKRESELELPVPGGGGDGAEPGLSKRPRTEEAAADGGGMQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 429, "header": "tr|A0A3Q1LPA8-1|A0A3Q1LPA8_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74188652, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076517.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076517.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058841.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058841.2" } ] } }, { "isoform_ac": "A0A3Q1M080-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1M080-1", "sequence": { "sequence": "MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVGTQPTDMHSPPLRPQPPPLPPLQPLTATVMAGCTPPTPTMPLPLPLVTELALWRVYTEVATADLPPTEVT", "length": 370, "header": "tr|A0A3Q1M080-1|A0A3Q1M080_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 73994890, "end_pos": 73901320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081618.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081618.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066608.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066608.2" } ] } }, { "isoform_ac": "A0A3Q1M221-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1M221-1", "sequence": { "sequence": "MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYSAEEMLTSHSKSLSGVSVPFSDITDGVGTQPTDMHSPPLRPQPPPLPPLQPLTATVMAGCTPPTPTMPLPLPLVTELALWRVYTEVATADLPPTEVT", "length": 406, "header": "tr|A0A3Q1M221-1|A0A3Q1M221_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 73994890, "end_pos": 73901320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067418.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067418.2" } ] } }, { "isoform_ac": "A0A3Q1M7M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1M7M2-1", "sequence": { "sequence": "MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 358, "header": "tr|A0A3Q1M7M2-1|A0A3Q1M7M2_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 73994890, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084156.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084156.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064382.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064382.2" } ] } }, { "isoform_ac": "A0A3Q1MG25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1MG25-1", "sequence": { "sequence": "MYGVYCMDYQYPVVQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 383, "header": "tr|A0A3Q1MG25-1|A0A3Q1MG25_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74005946, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076941.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076941.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073192.2" } ] } }, { "isoform_ac": "A0A3Q1MR30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1MR30-1", "sequence": { "sequence": "MAEGAQPQQPPQLGPGAAARGMKRESELELPVPGGGGDGAEPGLSKRPRTEEAAADGGGMQNEPLTPGYHGFPTRDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYIESANCFRSNRVGTQPTDMHSPPLRPQPPPLPPLQPLTATVMAGCTPPTPTMPLPLPLVTELALWRVYTEVATADLPPTEVT", "length": 460, "header": "tr|A0A3Q1MR30-1|A0A3Q1MR30_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74188652, "end_pos": 73901320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070015.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070015.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074136.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074136.2" } ] } }, { "isoform_ac": "A0A3Q1MZV1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0A3Q1MZV1-1", "sequence": { "sequence": "MYCTPTVCKGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 376, "header": "tr|A0A3Q1MZV1-1|A0AAA9TCV6_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=2 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74052491, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073356.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073356.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061812.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061812.2" } ] } }, { "isoform_ac": "A0AAA9SBN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0AAA9SBN1-1", "sequence": { "sequence": "MAEGAQPQQPPQLGPGAAARGMKRESELELPVPGGGGDGAEPGLSKRPRTEEAAADGGGMQNEPLTPGYHGFPTRDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 415, "header": "tr|A0AAA9SBN1-1|A0AAA9TCV6_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=1 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74188652, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079631.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079631.1" } ] } }, { "isoform_ac": "A0AAA9TCV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#A0AAA9TCV6-1", "sequence": { "sequence": "MEKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 380, "header": "tr|A0AAA9TCV6-1|A0AAA9TCV6_BOVIN Isoform 1 of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=1 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 73994890, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134197.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134197.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095904.1" } ] } }, { "isoform_ac": "F1N2A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6/entry#F1N2A9-1", "sequence": { "sequence": "MGRLQMLKHKNEPLTPGYHGFPTRDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQAHGEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPAAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY", "length": 395, "header": "tr|F1N2A9-1|F1N2A9_BOVIN Computationally mapped isoform of RNA binding protein fox-1 homolog 2 OS=Bos taurus OX=9913 GN=RBFOX2 PE=4 SV=4 CANONICAL=A0AAA9TCV6-1" }, "locus": { "chromosome": "5", "start_pos": 74186899, "end_pos": 73901330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026808.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026808.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026808.7", "url": "https://www.ensembl.org/id/ENSBTAP00000026808.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" }, { "name": "regulation of definitive erythrocyte differentiation", "id": "GO:0010724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010724", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TCV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCV6" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 187, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], 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"categories": [ "Protein" ] }, { "id": "F6Q8G9-1", "url": "https://www.uniprot.org/uniprotkb/F6Q8G9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAGSVPARYLVYFQYLGTDFNGVAAVRGVQRAVGVQNYLEEAAERLNSVMPVKFTISSRTDAGVHALSNAAHLDIQRRSDLPPFSPEVLTEALNTHLKHPAIRVLQAFRVPSHFHARHAAISRTYLYRLATGCPRPDRLPVFERNRCWALQADCLDVAAMQEAAQHLLGTHDFSAFQSAGSPASSPVRTLRRASVSPDPASPFVLPEESRQLQFWSMEFESQSFLYKQVRRMTAVLVAVGLGALMPAQVKAILESRDPLGKHQSRVAPAHGLFLKSVLYEGLGPTSMQPPRRPSETQYRSHR", "length": 303, "header": "tr|A0AAA9TCW3-1|A0AAA9TCW3_BOVIN Isoform 1 of tRNA pseudouridine synthase OS=Bos taurus OX=9913 GN=PUSL1 PE=3 SV=1 CANONICAL=A0AAA9TCW3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW3/entry#A0AAA9SRB6-1", "sequence": { "sequence": 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"A0AAA9TCW3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22376", "name": "", "equation": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TCW3-1", "E1BDL3-1" ], "evidence": [ { "id": "22376", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22376" } ] }, { "id": "54572", "name": "", "equation": "a uridine in tRNA = a pseudouridine in tRNA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DI8-1", "Q5E9Z1-1", "E1BDL3-1", "A0AAA9TCW3-1", "A0AAA9T9C6-1", "Q17QT4-1" ], "evidence": [ { "id": "54572", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54572" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { 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{ "id": "PTHR15076", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15076", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15076:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15076:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "A0AAA9TAX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAWRGLSCLTLLCVLLHVRGENGDFDLADALDDPKPTKKPSSGIYPNPRPPYQPQPGNPNNGGDIYPRTKPPPPRPQPGNSGGFLSDSDLIDGGRYPPRRPAGGGGGGFQPGHDGYGGAGHSTAGNQQGNMIAKIVSPIVSMVVVTLIGLAVRYYNQRRNSLRTNEPRTI", "length": 171, "header": "tr|A0AAA9TAX2-1|A0AAA9TAX2_BOVIN Isoform 1 of Xg glycoprotein OS=Bos taurus OX=9913 GN=XG PE=3 SV=2 CANONICAL=A0AAA9TAX2-1" }, "isoforms": [ { "isoform_ac": 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TA18-1", "uniprot_ac": "A0AAA9TA18", "uniprot_id": "A0AAA9TA18_BOVIN", "mass": { "chemical_mass": 37188.0, "monoisotopic_mass": 37188.0 }, "refseq": { "ac": "XP_005221943", "name": "mortality factor 4-like protein 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221943" }, "gene_names": [ { "name": "MORF4L1", "type": "recommended", "evidence": [ { "id": "A0AAA9TA18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ] }, { "name": "MORF4L1", "type": "synonym", "evidence": [ { "id": "XP_005221943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221943" } ] }, { "name": "MORF4L2", "type": "synonym", "evidence": [ { "id": "XP_005221943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221943" } ] } ], "protein_names": [ { "name": "Mortality factor 4-like protein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TA18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18/entry#names_and_taxonomy" } ] }, { "name": "mortality factor 4-like protein 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005221943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221943" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MORF4L1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18", "locus": { "chromosome": "21", "start_pos": 25194048, "end_pos": 25176585, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010988", "url": "https://www.ensembl.org/id/ENSBTAG00000010988" } ] } } ], "crossref": [ { "id": "A0AAA9TA18", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TA18", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010988", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010988", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18983", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18983", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614390", "url": "https://www.ncbi.nlm.nih.gov/gene/614390", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000953", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000953", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025995", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025995", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GLQTYFD", "url": "https://omabrowser.org/oma/group/GLQTYFD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LL49", "url": "https://www.orthodb.org/?gene=A0A3Q1LL49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10880", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10880:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10880:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05712", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221943", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221943", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTAGLQQKNLDVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMSRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 323, "header": "tr|A0AAA9TA18-1|A0AAA9TA18_BOVIN Isoform 1 of Mortality factor 4-like protein 1 OS=Bos taurus OX=9913 GN=MORF4L1 PE=4 SV=1 CANONICAL=A0AAA9TA18-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL49-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18/entry#A0A3Q1LL49-1", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKTLKTREDIVALFPVPEGAPSVHHPFLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTAGLQQKNLDVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMSRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 362, "header": "tr|A0A3Q1LL49-1|A0A3Q1LL49_BOVIN Computationally mapped isoform of Mortality factor 4 like 1 OS=Bos taurus OX=9913 GN=MORF4L1 PE=4 SV=1 CANONICAL=A0AAA9TA18-1" }, "locus": { "chromosome": "21", "start_pos": 25193888, "end_pos": 25176784, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083950.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083950.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057180.1" } ] } }, { "isoform_ac": "A0AAA9TA18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18/entry#A0AAA9TA18-1", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTAGLQQKNLDVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMSRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 323, "header": "tr|A0AAA9TA18-1|A0AAA9TA18_BOVIN Isoform 1 of Mortality factor 4-like protein 1 OS=Bos taurus OX=9913 GN=MORF4L1 PE=4 SV=1 CANONICAL=A0AAA9TA18-1" }, "locus": { "chromosome": "21", "start_pos": 25193888, "end_pos": 25176784, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105908.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105908.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092788.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092788.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "K7GQW8-1", "protein_name": "Mortality factor 4-like protein 1", "gene_name": "MORF4L1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGEGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 323 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P60762-1", "protein_name": "Mortality factor 4-like protein 1", "gene_name": "Morf4l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTREDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 362 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54RM0-1", "protein_name": "NuA4 complex subunit EAF3 homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDETYEENEKVLVHHQNRIYEAKIIKVDPKTSKSDKKKPLYFIHYLGWKEKWNEWIEPNKILKYTDKNRELQKRTNIKASTTSLNNKKNTKKAKEVKQQQQQQQPIAYDSENSDEDENESELEDGGGEDADEGGEDIEDQENNNNNDTGGEEADDNNTSPRSTGSSSSSSSSKSNNNNNNNNNNNNNNNNNNNNNNNNNNKRKRNDSKSSHFQSTKFIDIEIPLSLKNKLVDDWNSINNEKSILSLPKSPNVKDILNKIIEENDKSSECKEVINGIKQYFNKALGTLLLYKFERPQYDSILKTNPKKSMSDIYGAEHLLRLFVKLPQLLVISNLEEKTITQLKDAFEIVLEYLEKNSSTLFLKEYTIASSPYLKAASSN", "length": 379 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6AYU1-1", "protein_name": "Mortality factor 4-like protein 1", "gene_name": "Morf4l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDANLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 323 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q94C32-1", "protein_name": "Protein MRG1", "gene_name": "MRG1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGSSSKEETASDGDTASGGASPSNDGRLFSEGERVLAYHGPRVYGAKVQKVELRKKEWKYFVHYLGWNKNWDEWVSADRLLKHTEENLVKQKALDKKQGVEKGTKSGRSAQTKTRSSADTKADKDDTKTNAAKGKKRKHESGNEKDNVTAEKLMKIQIPASLKKQLTDDWEYIAQKDKVVKLPRSPNVDEILSKYLEFKTKKDGMVTDSVAEILKGIRSYFDKALPVMLLYKKERRQYQESIVDDTSPSTVYGAEHLLRLFVKLPDLFSYVNMEEETWSRMQQTLSDFLKFIQKNQSTFLLPSAYDSDKVSDGKGKGKDD", "length": 320 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UBU8-1", "protein_name": "Mortality factor 4-like protein 1", "gene_name": "MORF4L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKSAVRPRRSEKSLKTHEDIVALFPVPEGAPSVHHPLLTSSWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVEVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHRKAV", "length": 362 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Y0I1-1", "protein_name": "NuA4 complex subunit EAF3 homolog", "gene_name": "MRG15", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGEVKPAKVENYSTGTDANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGERSKKDNKKGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSNFINVDPEYVRNAQ", "length": 424 }, "evidence": [ { "id": "A0AAA9TA18", "url": "https://omabrowser.org/oma/group/A0AAA9TA18/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex", "id": "GO:0035267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TA18", "database": "UniProtKB", "url": 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"Protein" ] }, { "id": "A0AAA9TA36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA9", "url": "https://www.uniprot.org/uniprotkb/E1BPA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLYPSLEDLKVDQAMQAQAKAVPRMPALPVRGKGDSQPPLLYPNLAELENYMGLSLSSQEVQQSLPQTPESASAAVSGPSPGQVVAPVSGNSLGALRAEIKPGVREIHLCKDERGKTGLRLQAIDKGIFVQLVQANTPASLVGLRFGDQILQIDGRDCAGWSTDKAHQVVKKASAEKIVIIVRDRPFQRTITMHKDSTGHVGFVIKKGKIISLVKGSSAARNGLLTNHYVCEVNGQNVIGLKDKEVTEILATAGNVITLTIIPTVIYEHMVKKLSPTLLHHTMDHSIPDV", "length": 292, "header": "tr|A0AAA9TA36-1|A0AAA9TA36_BOVIN Isoform 1 of Syndecan binding protein 2 OS=Bos taurus OX=9913 GN=SDCBP2 PE=4 SV=1 CANONICAL=A0AAA9TA36-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MMT4-1", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9TA36/entry#A0AAA9TA36-1", "sequence": { "sequence": "MATLYPSLEDLKVDQAMQAQAKAVPRMPALPVRGKGDSQPPLLYPNLAELENYMGLSLSSQEVQQSLPQTPESASAAVSGPSPGQVVAPVSGNSLGALRAEIKPGVREIHLCKDERGKTGLRLQAIDKGIFVQLVQANTPASLVGLRFGDQILQIDGRDCAGWSTDKAHQVVKKASAEKIVIIVRDRPFQRTITMHKDSTGHVGFVIKKGKIISLVKGSSAARNGLLTNHYVCEVNGQNVIGLKDKEVTEILATAGNVITLTIIPTVIYEHMVKKLSPTLLHHTMDHSIPDV", "length": 292, "header": "tr|A0AAA9TA36-1|A0AAA9TA36_BOVIN Isoform 1 of Syndecan binding protein 2 OS=Bos taurus OX=9913 GN=SDCBP2 PE=4 SV=1 CANONICAL=A0AAA9TA36-1" }, "locus": { "chromosome": "13", "start_pos": 59813735, "end_pos": 59804887, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094885.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094885.1" } ] } }, { "isoform_ac": "E1BPA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36/entry#E1BPA9-1", "sequence": { "sequence": "MEIVENAVGEHFSGVFQGAAMATLYPSLEDLKVDQAMQAQAKAVPRMPALPVRGKGDSQPPLLYPNLAELENYMGLSLSSQEVQQSLPQTPESASAAVSGPSPGQVVAPVSGNSLGALRAEIKPGVREIHLCKDERGKTGLRLQAIDKGIFVQLVQANTPASLVGLRFGDQILQIDGRDCAGWSTDKAHQVVKKASAEKIVIIVRDRPFQRTITMHKDSTGHVGFVIKKGKIISLVKGSSAARNGLLTNHYVCEVNGQNVIGLKDKEVTEILATAGNVITLTIIPTVIYEHMVKKLSPTLLHHTMDHSIPDV", "length": 312, "header": "tr|E1BPA9-1|E1BPA9_BOVIN Computationally mapped isoform of Syndecan binding protein 2 OS=Bos taurus OX=9913 GN=SDCBP2 PE=4 SV=4 CANONICAL=A0AAA9TA36-1" }, "locus": { "chromosome": "13", "start_pos": 59813735, "end_pos": 59797056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039310.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039310.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039107.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039107.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617742", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617742", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TA36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA36" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 108, "end_pos": 187, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TDW8-1", "uniprot_ac": "A0AAA9TDW8", "uniprot_id": "A0AAA9TDW8_BOVIN", "mass": { "chemical_mass": 11682.0, "monoisotopic_mass": 11682.0 }, "refseq": { "ac": "XP_024838178", "name": "prokineticin-2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838178" }, "gene_names": [ { "name": "PROK2", "type": "recommended", "evidence": [ { "id": "A0AAA9TDW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8" } ] }, { "name": "Bv8", "type": "synonym", "evidence": [ { "id": "XP_024838178", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838178" } ] }, { "name": "PROK2", "type": "synonym", "evidence": [ { "id": "XP_024838178", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838178" } ] } ], 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May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.", "evidence": [ { "database": "UniProtKB", "id": "F1MMX1", "url": "https://www.uniprot.org/uniprotkb/F1MMX1#function" }, { "database": "UniProtKB", "id": "ARBA00054597", "url": "https://www.uniprot.org/uniprotkb/ARBA00054597#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PROK2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8", "locus": { "chromosome": "22", "start_pos": 29883008, "end_pos": 29859914, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019330", "url": "https://www.ensembl.org/id/ENSBTAG00000019330" } ] } } ], "crossref": [ { "id": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18821", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18821:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18821:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06607", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06607", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838178", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838178", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TDW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMX1", "url": "https://www.uniprot.org/uniprotkb/F1MMX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MMX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSPRCARLLLLLLLPPLLLTPPAGDAAVITGACDRDPQCGGGMCCAVSLWVKSIRICTPMGKVGDSCHPMTRKVPFLGRRMHHTCPCLPGLACSRTSFNRYTCLAQK", "length": 108, "header": "tr|A0AAA9TDW8-1|A0AAA9TDW8_BOVIN Isoform 1 of Prokineticin 2 OS=Bos taurus OX=9913 GN=PROK2 PE=3 SV=1 CANONICAL=A0AAA9TDW8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TDW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8/entry#A0AAA9TDW8-1", "sequence": { "sequence": "MRSPRCARLLLLLLLPPLLLTPPAGDAAVITGACDRDPQCGGGMCCAVSLWVKSIRICTPMGKVGDSCHPMTRKVPFLGRRMHHTCPCLPGLACSRTSFNRYTCLAQK", "length": 108, "header": "tr|A0AAA9TDW8-1|A0AAA9TDW8_BOVIN Isoform 1 of Prokineticin 2 OS=Bos taurus OX=9913 GN=PROK2 PE=3 SV=1 CANONICAL=A0AAA9TDW8-1" }, "locus": { "chromosome": "22", "start_pos": 29872574, "end_pos": 29859940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097412.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097412.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095096.1" } ] } }, { "isoform_ac": "F1MMX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8/entry#F1MMX1-1", "sequence": { "sequence": "MRSPRCARLLLLLLLPPLLLTPPAGDAAVITGACDRDPQCGGGMCCAVSLWVKSIRICTPMGKVGDSCHPMTRKNHFGNGRQERRKRKRRRKKKVPFLGRRMHHTCPCLPGLACSRTSFNRYTCLAQK", "length": 128, "header": "tr|F1MMX1-1|F1MMX1_BOVIN Computationally mapped isoform of Prokineticin-2 OS=Bos taurus OX=9913 GN=PROK2 PE=3 SV=3 CANONICAL=A0AAA9TDW8-1" }, "locus": { "chromosome": "22", "start_pos": 29872574, "end_pos": 29859940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025742.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025742.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025742.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025742.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZGF4-1", "protein_name": "Prokineticin 2", "gene_name": "PROK2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAASCLTLLLGHHQNLQLMEFLTALACDRDQQCGGGMCCAVSLWIRSLRMCTPMGNVGEECHPLSHRVPFPGRRMHHTCPCLPSLSCTRASPSKFRCLPDFRKEDVFF", "length": 109 }, "evidence": [ { "id": "A0AAA9TDW8", "url": "https://omabrowser.org/oma/group/A0AAA9TDW8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9HC23-1", "protein_name": "Prokineticin-2", "gene_name": "PROK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSLCCAPLLLLLLLPPLLLTPRAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGKLGDSCHPLTRKNNFGNGRQERRKRKRSKRKKEVPFFGRRMHHTCPCLPGLACLRTSFNRFICLAQK", "length": 129 }, "evidence": [ { "id": "A0AAA9TDW8", "url": "https://omabrowser.org/oma/group/A0AAA9TDW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXU7-1", "protein_name": "Prokineticin-2", "gene_name": "Prok2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDPRCAPLLLLLLLPLLFTPPAGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGQVGDSCHPLTRKSHVANGRQERRRAKRRKRKKEVPFWGRRMHHTCPCLPGLACLRTSFNRFICLARK", "length": 128 }, "evidence": [ { "id": "A0AAA9TDW8", "url": "https://omabrowser.org/oma/group/A0AAA9TDW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TDW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9TDW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TDW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW8" }, { "id": "PF06607", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06607" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Prokineticin", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 105, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], 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{ "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TB15-1", "uniprot_ac": "A0AAA9TB15", "uniprot_id": "A0AAA9TB15_BOVIN", "mass": { "chemical_mass": 36374.0, "monoisotopic_mass": 36374.0 }, "refseq": { "ac": "XP_005203781", "name": "zinc transporter ZIP1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203781" }, "gene_names": [ { "name": "SLC39A1", "type": "recommended", "evidence": [ { "id": "A0AAA9TB15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15" } ] }, { "name": "SLC39A1", "type": "synonym", "evidence": [ { "id": "XP_005203781", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203781" } ] } ], "protein_names": [ { "name": "Solute carrier family 39 member 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TB15", "database": "UniProtKB", "url": 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"url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TB15", "database": "AlphaFoldDB", "categories": [] }, { "id": "530352", "url": "https://www.ncbi.nlm.nih.gov/gene/530352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003689", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003689", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11040:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11040:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005203781", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203781", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TB15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAGKQPNSPCSGLRVIGATAATMGPWGEPELLVWRPEAAASEAPVPMGLEVKLGALVLLLVLTLICSLVPVCVLRRPGANPEASASRQKALSLVSCFAGGVFLATCLLDLLPDYLGAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPPPREETRALLGTVNGGPQHWHDGLGVPQAGGASSAPSALRACVLVFSLALHSVFEGLAVGLQRDQARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGTALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIQI", "length": 347, "header": "tr|A0AAA9TB15-1|A0AAA9TB15_BOVIN Isoform 1 of Solute carrier family 39 member 1 OS=Bos taurus OX=9913 GN=SLC39A1 PE=4 SV=1 CANONICAL=A0AAA9TB15-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15/entry#A0AAA9SIZ4-1", "sequence": { "sequence": "MGAGKQPNSPCSGLRVIGATAATMGPWGEPELLVWRPEAAASEAPVPMGLEVKLGALVLLLVLTLICSLVPVCVLRRPGANPEASAPVPSPRVHPGHGLLPGPGDGADHAGLQGTVGTTTSRGDEGSPGYSEWWATALARWTGGPTGRRSLISSLSPACLCIGLLLGPAFSV", "length": 172, "header": "tr|A0AAA9SIZ4-1|A0AAA9TB15_BOVIN Computationally mapped isoform of Solute carrier family 39 member 1 OS=Bos taurus OX=9913 GN=SLC39A1 PE=4 SV=1 CANONICAL=A0AAA9TB15-1" }, "locus": { "chromosome": "3", "start_pos": 16475754, "end_pos": 16473450, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093677.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093677.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086213.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086213.1" } ] } }, { "isoform_ac": "A0AAA9TB15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15/entry#A0AAA9TB15-1", "sequence": { "sequence": "MGAGKQPNSPCSGLRVIGATAATMGPWGEPELLVWRPEAAASEAPVPMGLEVKLGALVLLLVLTLICSLVPVCVLRRPGANPEASASRQKALSLVSCFAGGVFLATCLLDLLPDYLGAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPPPREETRALLGTVNGGPQHWHDGLGVPQAGGASSAPSALRACVLVFSLALHSVFEGLAVGLQRDQARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGTALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELATSEQRILKVILLLAGFALLTGLLFIQI", "length": 347, "header": "tr|A0AAA9TB15-1|A0AAA9TB15_BOVIN Isoform 1 of Solute carrier family 39 member 1 OS=Bos taurus OX=9913 GN=SLC39A1 PE=4 SV=1 CANONICAL=A0AAA9TB15-1" }, "locus": { "chromosome": "3", "start_pos": 16476148, "end_pos": 16473450, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095189.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095189.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion transmembrane transporter activity", "id": "GO:0005385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TB15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TB15" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9G5-1", "uniprot_ac": "A0AAA9T9G5", "uniprot_id": "A0AAA9T9G5_BOVIN", "mass": { "chemical_mass": 58923.0, "monoisotopic_mass": 58923.0 }, "refseq": {}, "gene_names": [ { "name": "SLC17A8", "type": "recommended", "evidence": [ { "id": "A0AAA9T9G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ] } ], "protein_names": [ { "name": "Solute carrier family 17 member 8", "type": "synonym", "evidence": [ { "id": "A0AAA9T9G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC17A8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5", "locus": { "chromosome": "5", "start_pos": 64336404, "end_pos": 64295905, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001088", "url": "https://www.ensembl.org/id/ENSBTAG00000001088" } ] } } ], "crossref": [ { "id": "A0AAA9T9G5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9G5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001088", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001088", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529659", "url": "https://www.ncbi.nlm.nih.gov/gene/529659", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529659", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529659", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VTTIFWN", "url": "https://omabrowser.org/oma/group/VTTIFWN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BA07", "url": "https://www.orthodb.org/?gene=E1BA07", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11662:SF207", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11662:SF207", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-442660", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66336", "url": "https://www.rhea-db.org/rhea/66336", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "71255", "url": "https://www.rhea-db.org/rhea/71255", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA07", "url": "https://www.uniprot.org/uniprotkb/E1BA07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA07-1", "url": "https://www.uniprot.org/uniprotkb/E1BA07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFKAFNTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEVNIELNEEGRPVQTPRQKPPLCDCHCCGVPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFFTSTLNMFIPSAARAHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGVLVQYIGWASVFYTYGILGIIWYMFWLLQAYECPAAHPTISQEERTYIETSIGEGANLVSLSVGLLSAVPHMVMTIIVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGMAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGIFASGEKQEWADPENLSEEKCGIIDQDELAEETELNHESFASPRKMSYGATTQNCEVQRKEWRGQRGVTLNEEELTSYQNEGGNFSDAS", "length": 538, "header": "tr|A0AAA9T9G5-1|A0AAA9T9G5_BOVIN Isoform 1 of Solute carrier family 17 member 8 OS=Bos taurus OX=9913 GN=SLC17A8 PE=3 SV=1 CANONICAL=A0AAA9T9G5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5/entry#A0AAA9T9G5-1", "sequence": { "sequence": "MPFKAFNTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEVNIELNEEGRPVQTPRQKPPLCDCHCCGVPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFFTSTLNMFIPSAARAHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGVLVQYIGWASVFYTYGILGIIWYMFWLLQAYECPAAHPTISQEERTYIETSIGEGANLVSLSVGLLSAVPHMVMTIIVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGMAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGIFASGEKQEWADPENLSEEKCGIIDQDELAEETELNHESFASPRKMSYGATTQNCEVQRKEWRGQRGVTLNEEELTSYQNEGGNFSDAS", "length": 538, "header": "tr|A0AAA9T9G5-1|A0AAA9T9G5_BOVIN Isoform 1 of Solute carrier family 17 member 8 OS=Bos taurus OX=9913 GN=SLC17A8 PE=3 SV=1 CANONICAL=A0AAA9T9G5-1" }, "locus": { "chromosome": "5", "start_pos": 64335686, "end_pos": 64296337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098624.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098624.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092548.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092548.1" } ] } }, { "isoform_ac": "E1BA07-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5/entry#E1BA07-1", "sequence": { "sequence": "MPFKAFNTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEVNIELNEEGRPVQTPRQKPPLCDCHCCGVPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFFTSTLNMFIPSAARAHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGVLVQYIGWASVFYTYGILGIIWYMFWLLQAYECPAAHPTISQEERTYIETSIGEGANLVSLSKFNTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIIVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGMAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGIFASGEKQEWADPENLSEEKCGIIDQDELAEETELNHESFASPRKMSYGATTQNCEVQRKEWRGQRGVTLNEEELTSYQNEGGNFSDAS", "length": 588, "header": "tr|E1BA07-1|E1BA07_BOVIN Computationally mapped isoform of Solute carrier family 17 member 8 OS=Bos taurus OX=9913 GN=SLC17A8 PE=3 SV=3 CANONICAL=A0AAA9T9G5-1" }, "locus": { "chromosome": "5", "start_pos": 64335686, "end_pos": 64296337, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001445.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001445.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001445.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001445.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:529659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529659", "resource": "KEGG Pathway" }, { "id": "R-BTA-442660", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "resource": "Reactome", "description": "SLC-mediated transport of neurotransmitters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKV3-1", "protein_name": "Solute carrier family 17 member 8", "gene_name": "SLC17A8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELNEEGRPVQTSRQRPPLCDCHCCGVPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGVLVQYIGWASVFYIYGMLGMLWYMFWLLQAYECPSAHPTISHEEKTYIETSIGEGANLVSLSKFNTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDRDELAEETELNHECFASPQKKMSYGATTQNCEVQRKEWRGQRRGTLDEEELTSYQNEEGTFSDTS", "length": 544 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2MTN4-1", "protein_name": "Vesicular glutamate transporter 3 isoform X1", "gene_name": "Slc17a8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEDNIELNEEGRPVQASRPHLPVCDCSCCGIPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQMAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNIFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYIFWLLQAYECPAAHPTISNAEKTYIETSIGEGANLASPSKFNTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADCLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPESLSEEKCGIIDQDELAEETELNHEAILSPRKKMSYGATTQNVKVQKSGWRQQREAAFDEEEALSYQNEGDYSETS", "length": 588 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YA39-1", "protein_name": "Solute carrier family 17 member 8", "gene_name": "SLC17A8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPFKGFHSLKERFFNPGKEEVKNTVSDSLGNLRRKIDGTNIEEDHIELTEEGRPVQASARKPQVCDCYCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYINGKPELQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFIANKLAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMFVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIVWYMFWLLHAYESPAAHPTITREERVYIETSIGEGASLASTNKFSTPWKRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIIVPIGGQIADFLRSRKILTTTTVRKVMNCGGFGMEATLLLVVGYSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYAIFASGEKQEWADPENLNEEKCGIIDQDELAEETEMNNETFVTPKKTYGATSQNSEIQRREWRKQKQMTQDMEEQTSYHYENGNFQDLS", "length": 587 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7TSF2-1", "protein_name": "Vesicular glutamate transporter 3", "gene_name": "Slc17a8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPLSYQNEEDFSETS", "length": 588 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7XJR2-1", "protein_name": "Probable anion transporter 3, chloroplastic", "gene_name": "ANTR3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATVGSLKPLHHSSCSSSFPRNPIVNRKALLGFVFDSARKNQIRCENLRYSSESDGKRRNAAAKKRNQSPERCAAEGVLTGGGGSEAIAEVRTMMPERIKVVILTACMMCLCNADRVVMSVAVVPLADKLGWSSSFLGVVQSSFLWGYIFSSVIGGALVDRYGGKRVLAWGVALWSLATLLTPWAAAHSTLALLCVRAFFGLAEGVAMPSMTTLLSRWFPMDERASAVGISMAGFHMGNVVGLLLTPLMLSSIGISGPFILFASLGLLWVSTWSSGVTNNPQDSPFITRSELRLIQAGKPVQPSTISPKPNPSLRLLLSKLPTWAIIFANVTNNWGYFVLLSWMPVYFQTVFNVNLKQAAWFSALPWATMAISGYYAGAASDFLIRTGHSVTSVRKIMQSIGFMGPGLSLLCLNFAKSPSCAAVFMTIALSLSSFSQAGFLLNMQDIAPQYAGFLHGISNCAGTLAAIVSTIGTGYFVQWLGSFQAFLTVTAFLYFATTVFWLLFATGERVF", "length": 512 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8BFU8-1", "protein_name": "Vesicular glutamate transporter 3", "gene_name": "Slc17a8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEDAIELNEEGRPVQTSRAHRPVCDCSCCGIPKRYICDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEDKCGIIDQDELAEETELNHETFVSPRKKMSYGATTQNCEVQKTEWRQQRESAFDGEEPLSYQAEGDFSETS", "length": 601 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NDX2-1", "protein_name": "Vesicular glutamate transporter 3", "gene_name": "SLC17A8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS", "length": 589 }, "evidence": [ { "id": "A0AAA9T9G5", "url": "https://omabrowser.org/oma/group/A0AAA9T9G5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "excitatory synapse", "id": "GO:0060076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "chloride channel activity", "id": "GO:0005254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "neurotransmitter transmembrane transporter activity", "id": "GO:0005326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005326", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "L-glutamate transmembrane transporter activity", "id": "GO:0005313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005313", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "sodium:phosphate symporter activity", "id": "GO:0005436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005436", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "L-glutamate uniporter activity", "id": "GO:0140788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140788", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "sodium ion transport", "id": "GO:0006814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "phosphate ion transport", "id": "GO:0006817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006817", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "neurotransmitter transport", "id": "GO:0006836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006836", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "regulation of synapse structure or activity", "id": "GO:0050803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "synaptic transmission, glutamatergic", "id": "GO:0035249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035249", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "phosphate ion homeostasis", "id": "GO:0055062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055062", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "neurotransmitter loading into synaptic vesicle", "id": "GO:0098700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098700", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "positive regulation of glutamate uptake involved in transmission of nerve impulse", "id": "GO:0051951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051951", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" }, { "name": "regulation of acetylcholine uptake", "id": "GO:0051631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 533, "end_pos": 535, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] }, { "id": "66336", "name": "", "equation": "L-glutamate(out) = L-glutamate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "66336", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66336" } ] }, { "id": "71255", "name": "", "equation": "3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71255" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] }, { "uniprot_ac": "Q5E9B7", "gene_name": "CLIC1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] } ] }, { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T9G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9G5" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 538, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 105, "end_pos": 107 }, { "start_pos": 106, "end_pos": 108 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 533, "end_pos": 535 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9T9Z2-1", "uniprot_ac": "A0AAA9T9Z2", "uniprot_id": "A0AAA9T9Z2_BOVIN", "mass": { "chemical_mass": 131070.0, "monoisotopic_mass": 131070.0 }, "refseq": {}, "gene_names": [ { "name": "VCPIP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ] } ], "protein_names": [ { "name": "Deubiquitinating protein VCPIP1", "type": "recommended", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#names_and_taxonomy" } ] }, { "name": "Valosin-containing protein p97/p47 complex-interacting protein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#names_and_taxonomy" } ] }, { "name": "Valosin-containing protein p97/p47 complex-interacting protein p135", "type": "synonym", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.", "evidence": [ { "database": "UniProtKB", "id": "E1BCH9", "url": "https://www.uniprot.org/uniprotkb/E1BCH9#function" }, { "database": "UniProtKB", "id": "ARBA00057273", "url": "https://www.uniprot.org/uniprotkb/ARBA00057273#function" }, { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VCPIP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2", "locus": { "chromosome": "14", "start_pos": 30873818, "end_pos": 30899215, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006695", "url": "https://www.ensembl.org/id/ENSBTAG00000006695" } ] } } ], "crossref": [ { "id": "A0AAA9T9Z2", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9T9Z2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22769", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22769", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539643", "url": "https://www.ncbi.nlm.nih.gov/gene/539643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KHSTETD", "url": "https://omabrowser.org/oma/group/KHSTETD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCH9", "url": "https://www.orthodb.org/?gene=E1BCH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14843", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14843", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14843:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14843:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02338", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02338", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689896", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCH9", "url": "https://www.uniprot.org/uniprotkb/E1BCH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCH9-1", "url": "https://www.uniprot.org/uniprotkb/E1BCH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTPPSLAAAAAATPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDSVRDVLVPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDASLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRFGDVQGQESESPLPTKIILTGQKAKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTVRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKPSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTMKPEDSAVTGRLSSKELQEQADKEMYSLCLLATLMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSTPHLDPRARETPVVRKHTTGTDFSSSSIKTEPSVFTAAPSNSELIRIAPGVVTTRDSRQLDPDMVEAQRKKLQEMVSSIQASMDKHLRDQSTEQSPSDPPQRKVEAVSSSVKSGSLQTGSPESFSPTGDTENLNIETADGCVAEALEAAFAERSEAQKGSSVEEPEEMDSQDAEMTNTTEPMDHS", "length": 1194, "header": "tr|A0AAA9T9Z2-1|A0AAA9T9Z2_BOVIN Isoform 1 of Deubiquitinating protein VCPIP1 OS=Bos taurus OX=9913 GN=VCPIP1 PE=4 SV=1 CANONICAL=A0AAA9T9Z2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T9Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#A0AAA9T9Z2-1", "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTPPSLAAAAAATPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDSVRDVLVPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDASLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRFGDVQGQESESPLPTKIILTGQKAKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTVRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKPSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTMKPEDSAVTGRLSSKELQEQADKEMYSLCLLATLMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSTPHLDPRARETPVVRKHTTGTDFSSSSIKTEPSVFTAAPSNSELIRIAPGVVTTRDSRQLDPDMVEAQRKKLQEMVSSIQASMDKHLRDQSTEQSPSDPPQRKVEAVSSSVKSGSLQTGSPESFSPTGDTENLNIETADGCVAEALEAAFAERSEAQKGSSVEEPEEMDSQDAEMTNTTEPMDHS", "length": 1194, "header": "tr|A0AAA9T9Z2-1|A0AAA9T9Z2_BOVIN Isoform 1 of Deubiquitinating protein VCPIP1 OS=Bos taurus OX=9913 GN=VCPIP1 PE=4 SV=1 CANONICAL=A0AAA9T9Z2-1" }, "locus": { "chromosome": "14", "start_pos": 30899016, "end_pos": 30874822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118403.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118403.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092747.1" } ] } }, { "isoform_ac": "E1BCH9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2/entry#E1BCH9-1", "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTPPSLAAAAAATPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDSVRDVLVPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDASLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRFGDVQGQESESPLPTKIILTGQKAKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTVRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKPSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTMKPEDSAVTGRLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSTPHLDPRARETPVVRKHTTGTDFSSSSIKTEPSVFTAAPSNSELIRIAPGVVTTRDSRQLDPDMVEAQRKKLQEMVSSIQASMDKHLRDQSTEQSPSDPPQRKVEAVSSSVKSGSLQTGSPESFSPTGDTENLNIETADGCVAEALEAAFAERSEAQKGSSVEEPEEMDSQDAEMTNTTEPMDHS", "length": 1223, "header": "tr|E1BCH9-1|E1BCH9_BOVIN Computationally mapped isoform of Deubiquitinating protein VCPIP1 OS=Bos taurus OX=9913 GN=VCPIP1 PE=4 SV=3 CANONICAL=A0AAA9T9Z2-1" }, "locus": { "chromosome": "14", "start_pos": 30899016, "end_pos": 30874822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008802.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008802.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008802.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008802.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 762, "start_aa": "Thr", "end_pos": 762, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr762", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539643", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689896", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689896", "resource": "Reactome", "description": "Ovarian tumor domain proteases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2BJ69-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "vcpip1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSLIPGSKQKDRRILCGMCPDPQCQAKLIFPAHTSMSIECTECGQRHEQKNLANVEEVTNPDVVLHNLLRNALLGVPGPPKKGSELVKVMGLSNYHCKLLSPILTRYGMDKQTGTAKLLKEMNQGDIFDCSLLGDRAFLIEQEHVSTVGYGRDRSGSLIYLHDTLEEIKKANGNRECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKLHFKQNLDRYKALFQDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPVILLDSLSGMRSSGDYSATFLPGLIPEEQCRGKDGTLNKPICIAWSSSGRNHYLPLVGIKGLALPRLPAALLPKAWGVPQELIRKYVSLDPSGSCVIGGDRSLQDKYLLRLVSAMEDVFMDKHSIHPALVADVHQYIYRRTGVIGVQPEEVTEAAKKSIQEGRLHRCLVCNALSELHVPAEWLIPGGKLYNLAKSTHGTLRADKNYSFPLNSLVCSYNPEKDVLVPDYKLSSLTTCTWCHGTSVRRVRGDGSVVYLDGDRTNTPSQGGKCGCGFKHFWEGKEYDNLPEAFPITLEWAGRVVRETVYWFQYEIDPTLNSNVYDVTMRLVTKHFPGEFGSEILVQKVVNTILHHTAKKSQDEYNPVAIEGAHVQNKVDGGESSAHPPTKIILTGQKGKTLHKEELVMSKTERVLQHSISEQAALSQRRSTDRVRHQDPRPSSPSSSSSSAPPTPTKVPPTSGEKKIRVTTSDGRQAMLTLQPHTTYSDLQNSIIQVFNLSPGQLCIRHGFPPRELPPPPPEDQNRPVALQHGDRISVEVLKESSADPQVTQTHTHSPQTHAHSDPRLSHSSSRELQDNIDLEMSSLCLLAALMGEDVWSYAKKLPHLFQQGGVFYNIVKKDMGLLDGKHCTLPHLSGKTFVFNATEERLELCVDTAGHFPVGPDVEELVQEALSQLRSDAASRSREGSPAHSLRLGSGGAVRKKEQNITAFQGKGHSLGSAPPEHPPIRRQHSSGVDLSGSARGEGLTLSGEDLVRVAPGMLTLREGRGMGLEPAVIEAQRQRLQEMVSNIQASMDKHLRQHTAARNDGKEEETPDKPEEMESHGPEPPNTFEPMDQS", "length": 1108 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0X7P8-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "VCPIP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQPRQQPPPPPSPQQQPQPPPPAAAKKRERRIFSGTCPDPKCQARLFFPAHGPQGAGSIECTDCGQRHEQRQLLAVEEVTDPDLVLHNLLRNALLGVSGAGPPRRNTELVKVLGLSNYHCKLLAPILARYGMDKQTGKAKLLTEMNQGDIFDCSLLGDRAFLIEPEHVETVGYGKDRSGSLIYLHDTLEDIKKANNSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKKHFEENLSHYKALFHDFIDVAEWEDIINECDPLFVPPEGVPMGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLVPLEKCMGKDGMLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPRKLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLMRLVAAMEEVFMSKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHRCLMCGALSEHHVPPEWLAPGGKLYNLAKNTHGQLRPDKNYSFPLNNLVCSYSPAKDVLVPDYSLSSLTTCNWCHSNLVRRVREDGSVLYLDGDRTNTRSTGGKCGCGFKHYWEGKEYDNLPEAFPITLEWSGRVVRETVYWFQYESDTSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVNTILHQTAKKNPDDYTPVNIDGAHAQRAGEVQQGQELESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNIADQASVMQKRKSEKMKQEHKGQPRTVSPGAVREGPSSAPATPTKTPYSPTSTKEKKIRITTNDGRQSMLTLKCTTTFLELQESIAREFNIPPYLQCIRYGFPPKELLPPKEGMENEPVPLQHGDRIAIEILKGKEESSQPAAAHSAHAVKHDDVTVTSKISSKELQEQVDKEMYSLCLLATLMGEDVWSYAKGLPQLFQQGGVFYSIMKKTTGLVDGKHCTFPHLPGKNFVYNAAEDRLELCVDAAGHFPIGPDVEDLVKEALSQVRAEATSRSREASPSHGMLKLGSGGVVKKKSEQLHNITAFQGKGHSLGTASGSQQHDQRAREAPLLRKHSTETDFSPAKIEPSVFPAASAKSELIRIAPGVVTMRDGRQLDPTLIEAQRKKLQEMISSIQASMDRHLRDQNAEQSASVDVSQRKVEAVSSTAKTGSFQAGLPEPFSAPGGTEHLNTESAGDNMVNSVGTTFPARSKAQKGNSVEELEEMDSQDAGITNVTEPMDHS", "length": 1216 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RTZ5-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "VCPIP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTPPSLAAAAAAAPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDSVKDVLVPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDASLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRVGDVQGQESESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTVRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHAVKTEESAVTGKLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASTAPHLDPRARETPVGRKHTAGTDFSNSSIKTEPSVFTASPSNSELIRIAPGVVTMRDSRQLDPDMVEAQRKKLQEMVSSIQASMDKHLRDQSTEQSPSDLPQRKVEVVSSSLKSGNLQTGLPESFSLTGGTENLNTDTAESCVAEALGAEFATRSKAQKGNSVEEPEEMDSQDAEMTNTAEPMDHS", "length": 1223 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CDG3-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "Vcpip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTSSSLAAAASPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLYGALSELHVPSEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDPVKDVLLPDYGLSNLTACNWCHGSSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWEGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDPSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRVGDVQGQELESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKPSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKGRAEGGPSTAAHSAHTVKQEEIAVTGKLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSHPHIDPRARETLAVRKHNTGTDFSNSSIKTEPPVFTAASSNSELIRIAPGVVTMRDGRQIDPDVVEAQRKKLQEMVSSIQASMDKHLRDQSAEQAPSDLSQRKVEVVSSVRPVNLQTGLPEPFSLTGGTENLNTETTDSHVADVLGAAFATRSKAQKENSMEEPEEMDSQDAETTNTTEPMDHS", "length": 1220 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CF97-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "Vcpip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQPPPPPPLPPPPPPPEAPQTSSSLAAAATPGGLSKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGRDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRPDKNYSFPLNNLVCSYDPVKDVLLPDYGLSNLTACNWCHGTSVRRVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWEGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDPSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRIGDVQGQELESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKGKAEGGPSTAAHSAHTVRQEEIAVTGKLSSKELQEQADKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYNIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASSNPHMDPRARETLAVRKHNTGTDFSNSSIKTEPPVFTAASSNSELIRIAPGVVTMRDGRQIDPDVVEAQRKKLQEMVSSIQASMDKHLRDQSTEQTPSDLSQRKVEAVSSSVRPGNLQTGLPESFSLTGGTENLNTETTDSRVADVLGAAFATRSKAQKENSMEEPEEMDSQDAETTNTTEPMDHS", "length": 1221 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96JH7-1", "protein_name": "Deubiquitinating protein VCPIP1", "gene_name": "VCPIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQPPPPPPPLPPPPPPPEAPQTPSSLASAAASGGLLKRRDRRILSGSCPDPKCQARLFFPASGSVSIECTECGQRHEQQQLLGVEEVTDPDVVLHNLLRNALLGVTGAPKKNTELVKVMGLSNYHCKLLSPILARYGMDKQTGRAKLLRDMNQGELFDCALLGDRAFLIEPEHVNTVGYGKDRSGSLLYLHDTLEDIKRANKSQECLIPVHVDGDGHCLVHAVSRALVGRELFWHALRENLKQHFQQHLARYQALFHDFIDAAEWEDIINECDPLFVPPEGVPLGLRNIHIFGLANVLHRPIILLDSLSGMRSSGDYSATFLPGLIPAEKCTGKDGHLNKPICIAWSSSGRNHYIPLVGIKGAALPKLPMNLLPKAWGVPQDLIKKYIKLEEDGGCVIGGDRSLQDKYLLRLVAAMEEVFMDKHGIHPSLVADVHQYFYRRTGVIGVQPEEVTAAAKKAVMDNRLHKCLLCGALSELHVPPEWLAPGGKLYNLAKSTHGQLRTDKNYSFPLNNLVCSYDSVKDVLVPDYGMSNLTACNWCHGTSVRKVRGDGSIVYLDGDRTNSRSTGGKCGCGFKHFWDGKEYDNLPEAFPITLEWGGRVVRETVYWFQYESDSSLNSNVYDVAMKLVTKHFPGEFGSEILVQKVVHTILHQTAKKNPDDYTPVNIDGAHAQRVGDVQGQESESQLPTKIILTGQKTKTLHKEELNMSKTERTIQQNITEQASVMQKRKTEKLKQEQKGQPRTVSPSTIRDGPSSAPATPTKAPYSPTTSKEKKIRITTNDGRQSMVTLKSSTTFFELQESIAREFNIPPYLQCIRYGFPPKELMPPQAGMEKEPVPLQHGDRITIEILKSKAEGGQSAAAHSAHTVKQEDIAVTGKLSSKELQEQAEKEMYSLCLLATLMGEDVWSYAKGLPHMFQQGGVFYSIMKKTMGMADGKHCTFPHLPGKTFVYNASEDRLELCVDAAGHFPIGPDVEDLVKEAVSQVRAEATTRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASGNPHLDPRARETSVVRKHNTGTDFSNSSTKTEPSVFTASSSNSELIRIAPGVVTMRDGRQLDPDLVEAQRKKLQEMVSSIQASMDRHLRDQSTEQSPSDLPQRKTEVVSSSAKSGSLQTGLPESFPLTGGTENLNTETTDGCVADALGAAFATRSKAQRGNSVEELEEMDSQDAEMTNTTEPMDHS", "length": 1222 }, "evidence": [ { "id": "A0AAA9T9Z2", "url": "https://omabrowser.org/oma/group/A0AAA9T9Z2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "regulation of protein localization to chromatin", "id": "GO:1905634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "Golgi reassembly", "id": "GO:0090168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "protein K48-linked deubiquitination", "id": "GO:0071108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane fusion", "id": "GO:0016320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016320", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "protein K11-linked deubiquitination", "id": "GO:0035871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035871", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" }, { "name": "protein-DNA covalent cross-linking repair", "id": "GO:0106300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T9Z2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1186, "end_pos": 1188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 709, "end_pos": 711, "annotation": "n_glycosylation_sequon" }, { "start_pos": 720, "end_pos": 722, "annotation": "n_glycosylation_sequon" }, { "start_pos": 925, "end_pos": 927, "annotation": "n_glycosylation_sequon" }, { "start_pos": 993, "end_pos": 995, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8940100", "name": "CDK1 phosphorylates VCPIP1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-BTA-8940103" ], "output_participant_list": [ "R-ALL-8931884", "R-BTA-8940104" ], "enzyme_list": [ "P48734-1", "A0AAA9T9Z2-1" ], "evidence": [ { "id": "R-BTA-8940100", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8940100" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8931884", "participant_name": "ADP [endoplasmic reticulum lumen]", "crossref": [ { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "ZINC000012360703", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-BTA-8940103", "participant_name": "VCPIP1 [endoplasmic reticulum lumen]", "crossref": [ { "id": "E1BCH9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006695", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000008802", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000008802", "database": "ENSEMBL", "url": "" }, { "id": "XP_024857596.1", "database": "RefSeq", "url": "" }, { "id": "53883", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8940104", "participant_name": "phospho-VCPIP1 [endoplasmic reticulum lumen]", "crossref": [ { "id": "ENSBTAT00000008802", "database": "ENSEMBL", "url": "" }, { "id": "53883", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000006695", "database": "ENSEMBL", "url": "" }, { "id": "E1BCH9", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000008802", "database": "ENSEMBL", "url": "" }, { "id": "XP_024857596.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9T9Z2", "gene_name": "VCPIP1", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9T9Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9Z2" }, { "id": "PS50802", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50802" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OTU", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 362, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33, 762 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1186, "end_pos": 1188 }, { "start_pos": 203, "end_pos": 205 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 535, "end_pos": 537 }, { "start_pos": 709, "end_pos": 711 }, { "start_pos": 720, "end_pos": 722 }, { "start_pos": 925, "end_pos": 927 }, { "start_pos": 993, "end_pos": 995 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TAX8-1", "uniprot_ac": "A0AAA9TAX8", "uniprot_id": "A0AAA9TAX8_BOVIN", "mass": { "chemical_mass": 163447.0, "monoisotopic_mass": 163447.0 }, "refseq": {}, "gene_names": [ { "name": "NEXMIF", "type": "recommended", "evidence": [ { "id": "A0AAA9TAX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ] } ], "protein_names": [ { "name": "Neurite extension and migration factor", "type": "synonym", "evidence": [ { "id": "A0AAA9TAX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEXMIF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8", "locus": { "chromosome": "X", "start_pos": 76428370, "end_pos": 76218556, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000300", "url": "https://www.ensembl.org/id/ENSBTAG00000000300" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000300", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000300", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512493", "url": "https://www.ncbi.nlm.nih.gov/gene/512493", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042794", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042794", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512493", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512493", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETHIFQK", "url": "https://omabrowser.org/oma/group/ETHIFQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BF32", "url": "https://www.orthodb.org/?gene=E1BF32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46946", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46946", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46946:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46946:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15735", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF32", "url": "https://www.uniprot.org/uniprotkb/E1BF32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BF32-1", "url": "https://www.uniprot.org/uniprotkb/E1BF32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNQQDKAIVASTNGENTMINGVKENDSEDQDVAMKSFAALEAAAPIQSIPVAQKENLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGVAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDSVDPEPGISLKVSDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRREAEKPDIDLEDPGQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKTGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEEKGAEKKDGKDNDEKSALNKPCSGTEVGQFKNLKQGHLANSLEASGNFSDGSSFIEVSFDTMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPGGSIEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGRVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNSNADSSKTSLCQKQSFEPGSFEMSFLPPARKRKSKLGNRHRIQRIPSIETSASGKQVSFCNDERQANNRKEDGGLKGTLKSAPLAASSCANGSHLNDITGPDSEKVKAQDGQFKAPERKVLNKIKFKSEARLKSKKIKAGQESKPVVQMSPLLENQSSKANSKNEPIAGTSNSSHLSEFHETKVAKNSTFLPTSCSSEMPLSSAHVANNIPVIPGGYLQTLLDASDLSNNTGISYFNHHSPEQNEDRLTQTEKSFVPLQPSQDCVLSSPSESELLQSSQNFKMESSSYGDVWHNKPTSGSQEFMAEVSREIAPTQSSEFGVSQVVSMENSLTATTYSPICLNSGGSSCNKVIYTSVQDTQLSSDDSYQLCHFNNGEVCFPFQQGPVNMDNVRLFSFDSIAPLSVNSSNYCSLSLKSCEKDGDDDIADDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEISPPDTPSLSPQITRCENIKTLGTLKGFQEGVPGTLGNMEKIKWDCSTLSQQVQVDDGFTLHNHQFQFHMFNDEDSVSLLQKAPCLSTFNDPSSQISTSNKVSKSRKKSSPSKSGAMNQSSSQKNNRKKSPKSNNKGMEKPPGKTSRQVPKSAKKGKFMAAINGEKMQIGISRGGGQINSISSTGKTLAECIQHGPVASMKMPSQKGLSGDWSLGKESSPGWNDMNMGTSTNNLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKVNSGSPGATKNHRSIKGVSKSNGKAAIGDPGRASMSGYNEDSRSAFFDKKLNNLSTLGNNVPTHKKLYRHKTSSKALREEKCKGKRMEREQVHKDEAGTASFEKLR", "length": 1484, "header": "tr|A0AAA9TAX8-1|A0AAA9TAX8_BOVIN Isoform 1 of Neurite extension and migration factor OS=Bos taurus OX=9913 GN=NEXMIF PE=4 SV=1 CANONICAL=A0AAA9TAX8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8/entry#A0AAA9TAX8-1", "sequence": { "sequence": "MDNQQDKAIVASTNGENTMINGVKENDSEDQDVAMKSFAALEAAAPIQSIPVAQKENLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGVAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDSVDPEPGISLKVSDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRREAEKPDIDLEDPGQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKTGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEEKGAEKKDGKDNDEKSALNKPCSGTEVGQFKNLKQGHLANSLEASGNFSDGSSFIEVSFDTMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPGGSIEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGRVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNSNADSSKTSLCQKQSFEPGSFEMSFLPPARKRKSKLGNRHRIQRIPSIETSASGKQVSFCNDERQANNRKEDGGLKGTLKSAPLAASSCANGSHLNDITGPDSEKVKAQDGQFKAPERKVLNKIKFKSEARLKSKKIKAGQESKPVVQMSPLLENQSSKANSKNEPIAGTSNSSHLSEFHETKVAKNSTFLPTSCSSEMPLSSAHVANNIPVIPGGYLQTLLDASDLSNNTGISYFNHHSPEQNEDRLTQTEKSFVPLQPSQDCVLSSPSESELLQSSQNFKMESSSYGDVWHNKPTSGSQEFMAEVSREIAPTQSSEFGVSQVVSMENSLTATTYSPICLNSGGSSCNKVIYTSVQDTQLSSDDSYQLCHFNNGEVCFPFQQGPVNMDNVRLFSFDSIAPLSVNSSNYCSLSLKSCEKDGDDDIADDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEISPPDTPSLSPQITRCENIKTLGTLKGFQEGVPGTLGNMEKIKWDCSTLSQQVQVDDGFTLHNHQFQFHMFNDEDSVSLLQKAPCLSTFNDPSSQISTSNKVSKSRKKSSPSKSGAMNQSSSQKNNRKKSPKSNNKGMEKPPGKTSRQVPKSAKKGKFMAAINGEKMQIGISRGGGQINSISSTGKTLAECIQHGPVASMKMPSQKGLSGDWSLGKESSPGWNDMNMGTSTNNLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKVNSGSPGATKNHRSIKGVSKSNGKAAIGDPGRASMSGYNEDSRSAFFDKKLNNLSTLGNNVPTHKKLYRHKTSSKALREEKCKGKRMEREQVHKDEAGTASFEKLR", "length": 1484, "header": "tr|A0AAA9TAX8-1|A0AAA9TAX8_BOVIN Isoform 1 of Neurite extension and migration factor OS=Bos taurus OX=9913 GN=NEXMIF PE=4 SV=1 CANONICAL=A0AAA9TAX8-1" }, "locus": { "chromosome": "X", "start_pos": 76427644, "end_pos": 76422495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093749.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093749.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095153.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095153.1" } ] } }, { "isoform_ac": "E1BF32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8/entry#E1BF32-1", "sequence": { "sequence": "MDNQQDKAIVASTNGENTMINGVKENDSEDQDVAMKSFAALEAAAPIQSIPVAQKENLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGVAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDSVDPEPGISLKVSDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRREAEKPDIDLEDPGQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKTGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEEKGAEKKDGKDNDEKSALNKPCSGTEVGQFKNLKQGHLANSLEASGNFSDGSSFIEVSFDTMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPGGSIEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGRVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNSNADSSKTSLCQKQSFEPGSFEMSFLPPARKRKSKLGNRHRIQRIPSIETSASGKQVSFCNDERQANNRKEDGGLKGTLKSAPLAASSCANGSHLNDITGPDSEKVKAQDGQFKAPERKVLNKIKFKSEARLKSKKIKAGQESKPVVQMSPLLENQSSKANSKNEPIAGTSNSSHLSEFHETKVAKNSTFLPTSCSSEMPLSSAHVANNIPVIPGGYLQTLLDASDLSNNTGISYFNHHSPEQNEDRLTQTEKSFVPLQPSQDCVLSSPSESELLQSSQNFKMESSSYGDVWHNKPTSGSQEFMAEVSREIAPTQSSEFGVSQVVSMENSLTATTYSPICLNSGGSSCNKVIYTSVQDTQLSSDDSYQLCHFNNGEVCFPFQQGPVNMDNVRLFSFDSIAPLSVNSSNYCSLSLKSCEKDGDDDIADDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEISPPDTPSLSPQITRCENIKTLGTLKGFQEGVPGTLGNMEKIKWDCSTLSQQVQVDDGFTLHNHQFQFHMFNDEDSVSLLQKAPCLSTFNDPSSQISTSNKVSKSRKKSSPSKSGAMNQSSSQKNNRKKSPKSNNKGMEKPPGKTSRQVPKSAKKGKFMAAINGEKMQIGISRGGGQINSISSTGKTLAECIQHGPVASMKMPSQKGLSGDWSLGKESSPGWNDMNMGTSTNNLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKVNSGSPGATKNHRSIKGVSKSNGKAAIGDPGRASMSGYNEDSRSAFFDKKLNNLSTLGNNVPTHKKLYRHKTSSKALREEKCKGKRMEREQVHKDEAGTASFEKLRDSDYNLLNAETTFWVLPVFEEETLIFQKDI", "length": 1514, "header": "tr|E1BF32-1|E1BF32_BOVIN Computationally mapped isoform of Neurite extension and migration factor OS=Bos taurus OX=9913 GN=NEXMIF PE=4 SV=3 CANONICAL=A0AAA9TAX8-1" }, "locus": { "chromosome": "X", "start_pos": 76428331, "end_pos": 76422495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000375.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000375.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000375.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000375.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512493", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512493", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YMF7-1", "protein_name": "Neurite extension and migration factor", "gene_name": "KIAA2022", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDDQQEQDCASEDQETILINGVKENEPRTSDGEERPYSAADTTDAFPALTAAPKETQACHRVLPPLPAKKPCSLSPPSPLRLTDVPEHTSDDSSAHAISLTSCVTKGMSSWSLPGDCEKAPFSMMEPGGMSALTGDCLMQPSRTCLGCFIESKDGIDAEPGISLKVGDINRDYDTCSVSDIGIHCMSTGETMRYGDQLLSDQLLSFPMHKSRAADKRDAEKSDSDSEDPTQKNYYEGLLLDKCNGEEPLLTNPNQEWGYFESFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDDSTLGSDVCSLKIRYESFQDNVREKTTALQEDAQFNFFPSVFGNCTKRDSRSTLKRGPGGATDPSQFKSEEGIIWGEEEEDGEEEDGEEEEKAALNKSCNSTEVVQYVGPKRSHFLDSVNSTEDSGEFSDDSTCTESSYDVLRDIKDCSRYLSRDHSSSFIQQNYGLRAKRKVRYSDDYLYDVDSIENEKILDKKEWLPDGPKEEDDDEWCPKKRRKVSRKEPPVIIKYIIINRFKGEKHMLVKLSKVDANETTVTLNEELLSKYEKLAPLKGFWQERQQSRLDLLRSSLYHKQNFYLNGSDASFLPHPRKRKCKLANRHRIQRIKAIEQSVNKLGSCSSDHKQPCSSKEDAGLKGLQALAIATPSCANGLHVNDITDIAAVKCKSQEREYKGTERKVLRRIKFKSEARLKCKKIKADASVVEGCPALGDQDSAVHLKDDNIPCASDSSHHPECHEDKIAKNSPFLPSTSSSDKPLPSANITTNVPLIPGGYLQTLLDASDLSSSTGISYFAQHPSEQQHPLPSIIPADKPFTALQPSQSCVLSPPSESELQQSPGHLEMEQSTFGSVWPASKAAGSNRQEFTGELQDTAALTGEFGGAAGTDGLPASGYPQVNLNSSKLLYQKNYMPDSQQVQPDDSYQSCHFNNGEGRFHFQRGTLSTDDGRLISFDSVGSLSVSSSNYSSLKSCEKDGDDDINDDFLAHCSPKLVIQQSIDEITPLKESTDLLDISNFTPDKFRQSSLSEMSPPDTPNLSPQIAGSDTKPLGTLKGFPESAQAALSSSEKVKWNCGVLQTEEQADNGFTLNNHQFQFHMFNDEDSVSLLEKRPCLSTFNEPSGQISTNSKVSKSKRKSSSSKNAGTNQSSSQKTTRKKSPKTNKGTDKPQGKNSRQAPKSTRKGKNAASLSSEKAQVGGSRAVSQLASPASAPKGLAEGIQHSSQATGKLGKHNGLAGEWALGKDSGTAWSETSLGSTTGLLDDDQREFEEPSNILSNIASGMADVQRFMMASIEPLWGPVNHNSVPDIFRSPESNSLKLKTLKILAGTPQESKKKANSSSPGMAKNHKSNNKGSSKNSKAATCDPGRPNCSAGYNTDIHSPFFDKNYSNLSTLGNNGPTHKKLYRHKSSSKSLRDENCKIKRTDREQTHKDPPVTASFEKLRESDSILLKAETTFLVFPVFEEETPFSRKKTFDVSFFCLFVFVHSFQNMPCGMLKCKC", "length": 1511 }, "evidence": [ { "id": "A0AAA9TAX8", "url": "https://omabrowser.org/oma/group/A0AAA9TAX8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZGX1-1", "protein_name": "Neurite extension and migration factor", "gene_name": "Nexmif", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDNQQDKVIAASANGENNLINGVKENDSEEQDVAMKSFAALEASTPIQPIPVVQKESPMFPRGLLPLPSKKPCMQSPPSPLGLIEAPDHSATGASVNAISLTSGVAKGLNTWSLPNECEKAPFAIMEPAGISALNGDCLMQPSRTCLGCFMESKEAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENLKYGEQLLSDQLLGFPLHKSRAGDRRESEKPDIDLEDPTQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVENYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGVLKQSSDLSQFKVPDVSIIWGDEDKNLDKKKGKEEVHEDKSIEKKDEKDNGEKPALNNKPCSGLEVEQFKNLKPDHLTNSLETSGNFSDDSSFIEVSYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWPPGGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSESQLSKYAKLSPLKGFWQKKKKQKNGNTDSVKTPFCQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIQSMEASASSKQVSFGSDQKQASNRKEEGGLKGTPKSALLAAPSSANGSHLRGLIGPDSAKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKIKTGQENKPVVQMSPVSEDPSSKANLKNEVTPGTSNSSHMSEFHETKVVKNSTFLPTTCSSEMPLSSANVATNIPVIPGGYLQTLLDASDLSNNTSISYFTNHSAEQNEASLSQTEKAFAPLQSAQDCVLSSSSDSQLQQSSQNFKMEASNYGSLWPDKDTSGSQEFMTEVSGEIATSQSSEFEATQVVSMENNLTAITYSPVCLNSGGSGCNKVLYASVQDSHLAPDDSYQLCHFNNGEICFPFQQGPISTEDDGQLFSFDSMTPLSVSSSSYCPLSLKSCEKDGDDDINDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQSTRCESIKTLGTMKGFQEGVPGSLSSMEKIKWDCSTLSQQVQADDGFTLNNHQFQFHMFNDEDSVGLLQKNPCLSTFDEPAGQISANNKVSKSRKKTSPGKSGAVSQSSSQKNTRKKSPKASNKGVEKPPSKTSRQVPKSAKKGKYVAAVNGEKMQIGIGHSGGQPNSTSSNGKTLTECIQHGGPVAPMKIPSQKGLSGDWALGKESRPGWNDMSVVTNTNNLLDDDQREFQEPSYILSNIASGMADVQRFMMASMEPLWEPMEHQGESNTFYSPDSNSLKLKTLKILAGTPQESKKKINNGSSGATKNHRSIKAVSKSSGKAAVGDPGHADVSGSSEDSRSAFFDKKYSNMNTLGNNGPTHKKLYRHKSSSKTLRDEKYKGKRVEREQIHKDEAGTTCFEKLRGSSYNLLKAETAFGVLPVFEEETHIFQKDI", "length": 1517 }, "evidence": [ { "id": "A0AAA9TAX8", "url": "https://omabrowser.org/oma/group/A0AAA9TAX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DTT1-1", "protein_name": "Neurite extension and migration factor", "gene_name": "Nexmif", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDNQQDKVIAASANGDNNLINGVKNNDSEDQEVAMKSFVALEATTPIQPIPVIQKESPMFPRGLLPPPSKKPCMQSPPSPLALIEAPDHSANSASVNAISLTSGVAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKEAVDPEPGISLKVSDLNRDYETCAVSDIGIQCINAGENIKYGEQLLSDQLLGFPLHKSRAGDRRESEKPDIDLEDPTQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVENYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGILKQSSDLSQFKVPDVSIIWGEEDKNLDKKKGKEEVHEDKSIETKDEKDNGEKPALNNKPCGGLEVEQFKNLKADQLTNSLETSGNFSDDSSFIEVSYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWPPGGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLSKVDASETTVNLSENQLSKYAKLSPLKGFWQKKKKQKNSNTDSVKTPLCQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIQSVETSASSKQVSFCSDQKQACNRKEDGVKGTPKSALLTDPSCANGSHLRGLIVSDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKIKAGQENKPVVQMSPVSEDTSSKANLKNEVTPGTSNSSHMSEFHETKVKNSTFLPTTCSSEMPLSSANVATNIPVIPGGYLQTLLDASDLSNNTSISYFTNHSAEQNEGSLTQTEKAFVPLQSAQDCVLSSSSDSQLQQSSQNFKMEASNFGSLWPDKDTSGSQEFMTEVSREIATNQSSEFEASQVVSMENNLTAITYSPVCLNSDASGCNKVLYASLQDSHLPPEDLYQLCHFNNGEICFPFQQGPLSTDDDGRLFSFDSMTSLTVSSSNYCSLSLKSCEKDGDDEINDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLLEMSPPDTPSLSPQSTRCESIKTLGTMKGFQEGVPGSLSTVEKIKWDCNTLSQQAQADDGFTLNSHQFQFHMFNDEDSVGLLQKSPCLSTFDEPAGQINTNSKVSKSRKKTSPGKSGAVSQSSSQKNSRKKSPKASNKGVEKPPSKTSRQVPKSTKKGKYVAAVNGEKMQIGIGHSGGQPNSTSSNAKTLTECIQHGGPVASMKIPSQKGLSGDWALGKESRPGWNDMSVVTNTNNLLDDDQREFQEPSYILSNIASGMADVQRFMMASMEPLWEPMEHQGESNTFYSPDSNSLKLKTLKILAGTPQESKKKVTNGSSGATKNHRSVKAVSKSNGKAAIGEPGHADMPGSSEDSRSAFFDKKYSNVNTLGNNGPTHKKLYRHKSSSKGLRDEKYKGKRVEREQAHKDEAGTTSFEKLRDSNYNLLKAETAFGVLPVFEEETHIFQKDI", "length": 1515 }, "evidence": [ { "id": "A0AAA9TAX8", "url": "https://omabrowser.org/oma/group/A0AAA9TAX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5QGS0-1", "protein_name": "Neurite extension and migration factor", "gene_name": "NEXMIF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAAAPIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLTSGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPEPGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRRETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLCSKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQFNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQEDKGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISYDAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERKEWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETTVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPPARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGAPSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQESKPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPLSSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQPTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSSEFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNGEICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHCSPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCESMKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDSVSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGNNKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECIQHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYILSNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESKKKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMSTLGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLRDSDYNLLKAETTFWVLPVFEEETRIFQKDI", "length": 1516 }, "evidence": [ { "id": "A0AAA9TAX8", "url": "https://omabrowser.org/oma/group/A0AAA9TAX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of cell-matrix adhesion", "id": "GO:0001953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001953", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" }, { "name": "negative regulation of cell adhesion mediated by integrin", "id": "GO:0033629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033629", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" }, { "name": "negative regulation of neuron migration", "id": "GO:2001223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001223", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" }, { "name": "negative regulation of cell-cell adhesion mediated by cadherin", "id": "GO:2000048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000048", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TAX8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1001, "end_pos": 1003, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1056, "end_pos": 1058, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1187, "end_pos": 1189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1431, "end_pos": 1433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 751, "end_pos": 753, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" }, { "start_pos": 783, "end_pos": 785, "annotation": "n_glycosylation_sequon" }, { "start_pos": 825, "end_pos": 827, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TAX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAX8" }, { "id": "PF15735", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15735" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DUF4683", "eco_id": "ECO_0000259", "start_pos": 284, "end_pos": 671, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1001, "end_pos": 1003 }, { "start_pos": 1056, "end_pos": 1058 }, { "start_pos": 1187, "end_pos": 1189 }, { "start_pos": 1431, "end_pos": 1433 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 751, "end_pos": 753 }, { "start_pos": 768, "end_pos": 770 }, { "start_pos": 783, "end_pos": 785 }, { "start_pos": 825, "end_pos": 827 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TGZ1-1", "uniprot_ac": "A0AAA9TGZ1", "uniprot_id": "A0AAA9TGZ1_BOVIN", "mass": { "chemical_mass": 97670.0, "monoisotopic_mass": 97670.0 }, "refseq": { "ac": "XP_010814396", "name": "zinc finger protein 624", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814396" }, "gene_names": [ { "name": "ZNF624", "type": "recommended", "evidence": [ { "id": "A0AAA9TGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ] }, { "name": "ZNF624", "type": "synonym", "evidence": [ { "id": "XP_010814396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814396" } ] } ], "protein_names": [ { "name": "Zinc finger protein 624", "type": "synonym", "evidence": [ { "id": "A0AAA9TGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 624", "type": "synonym", "evidence": [ { "id": "XP_010814396", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814396" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" }, { "database": "UniProtKB", "id": "A0A3Q1LL37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL37#function" }, { "database": "UniProtKB", "id": "F1MGA9", "url": "https://www.uniprot.org/uniprotkb/F1MGA9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF624", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1", "locus": { "chromosome": "19", "start_pos": 33101808, "end_pos": 33088965, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031071", "url": "https://www.ensembl.org/id/ENSBTAG00000031071" } ] } } ], "crossref": [ { "id": "A0AAA9TGZ1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TGZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031071", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031071", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "104975043", "url": "https://www.ncbi.nlm.nih.gov/gene/104975043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:104975043", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104975043", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GGLWKWN", "url": "https://omabrowser.org/oma/group/GGLWKWN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGA9", "url": "https://www.orthodb.org/?gene=F1MGA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF142", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF142", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010814396", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814396", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGA9", "url": "https://www.uniprot.org/uniprotkb/F1MGA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVVFSVGPLSPQVFQPEEDLHLQAEEPELVKESVTFKDVAVDFTLEEWRLMDPTQRDLHKDVMLENYRNLVSLGLAISKPDMISHLENGKGPWVVVREISRTPFSELETKPTTKNTIPTEDFSKKHLSQDAIVEKLTENGLWDPIMGGLWKWGDRILRLQYSQQSPVGQKTVKPKKIPTIQKGFEFGTVLLPEPEVITEEPHGKYQTHDGNFTEGLDLITDTHLRKEICKDTEGSKVTSPASELTLEKKPNKKEKPYKCSTCEKAFRYRSLLNQHQRTHTKEKPYECNECGKMFSQPSYLSQHKKIHTGEKPYKCSECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGDKPYKCNDCGKAFRNKSYLSVHQKTHTEEKPYKCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECSECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLSVHHRMHTGEKPYKCNECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYTCYNCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYRCEECGKAFRTNSDFIVHLRMHTGEKPYKCSECGKAFRSSSSLTVHQRTHQREIQLI", "length": 848, "header": "tr|A0AAA9TGZ1-1|A0AAA9TGZ1_BOVIN Isoform 1 of Zinc finger protein 624 OS=Bos taurus OX=9913 GN=ZNF624 PE=3 SV=1 CANONICAL=A0AAA9TGZ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL37-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1/entry#A0A3Q1LL37-1", "sequence": { "sequence": "MAAVVFSVGPLSPQVFQPEEDLHLQAEEPELVKESVTFKDVAVDFTLEEWRLMDPTQRDLHKDVMLENYRNLVSLELETKPTTKNTIPTEDFSKKHLSQDAIVEKLTENGLWDPIMGGLWKWGDRILRLQYSQQSPVGQKTVKPKKIPTIQKGFEFGTVLLPEPEVITEEPHGKYQTHDGNFTEGLDLITDTHLRKEICKDTEGSKVTSPASELTLEKKPNKKEKPYKCSTCEKAFRYRSLLNQHQRTHTKEKPYECNECGKMFSQPSYLSQHKKIHTGEKPYKCSECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGDKPYKCNDCGKAFRNKSYLSVHQKTHTEEKPYKCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECSECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLSVHHRMHTGEKPYKCNECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYTCYNCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYRCEECGKAFRTNSDFIVHLRMHTGEKPYKCSECGKAFRSSSSLTVHQRTHQREIQLI", "length": 816, "header": "tr|A0A3Q1LL37-1|A0AAA9TGZ1_BOVIN Computationally mapped isoform of Zinc finger protein 624 OS=Bos taurus OX=9913 GN=ZNF624 PE=3 SV=1 CANONICAL=A0AAA9TGZ1-1" }, "locus": { "chromosome": "19", "start_pos": 33101284, "end_pos": 33092442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085917.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085917.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057159.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057159.1" } ] } }, { "isoform_ac": "A0AAA9TGZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1/entry#A0AAA9TGZ1-1", "sequence": { "sequence": "MAAVVFSVGPLSPQVFQPEEDLHLQAEEPELVKESVTFKDVAVDFTLEEWRLMDPTQRDLHKDVMLENYRNLVSLGLAISKPDMISHLENGKGPWVVVREISRTPFSELETKPTTKNTIPTEDFSKKHLSQDAIVEKLTENGLWDPIMGGLWKWGDRILRLQYSQQSPVGQKTVKPKKIPTIQKGFEFGTVLLPEPEVITEEPHGKYQTHDGNFTEGLDLITDTHLRKEICKDTEGSKVTSPASELTLEKKPNKKEKPYKCSTCEKAFRYRSLLNQHQRTHTKEKPYECNECGKMFSQPSYLSQHKKIHTGEKPYKCSECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGDKPYKCNDCGKAFRNKSYLSVHQKTHTEEKPYKCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECSECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLSVHHRMHTGEKPYKCNECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYTCYNCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYRCEECGKAFRTNSDFIVHLRMHTGEKPYKCSECGKAFRSSSSLTVHQRTHQREIQLI", "length": 848, "header": "tr|A0AAA9TGZ1-1|A0AAA9TGZ1_BOVIN Isoform 1 of Zinc finger protein 624 OS=Bos taurus OX=9913 GN=ZNF624 PE=3 SV=1 CANONICAL=A0AAA9TGZ1-1" }, "locus": { "chromosome": "19", "start_pos": 33101284, "end_pos": 33092442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130865.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130865.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097489.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097489.1" } ] } }, { "isoform_ac": "F1MGA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1/entry#F1MGA9-1", "sequence": { "sequence": "MDPTQRDLHKDVMLENYRNLVSLGLAISKPDMISHLENGKGPWVVVREISRTPFSELETKPTTKNTIPTEDFSKKHLSQDAIVEKLTENGLWDPIMGGLWKWGDRILRLQYSQQSPVGQKTVKPKKIPTIQKGFEFGTVLLPEPEVITEEPHGKYQTHDGNFTEGLDLITDTHLRKEICKDTEGSKVTSPASELTLEKKPNKKEKPYKCSTCEKAFRYRSLLNQHQRTHTKEKPYECNECGKMFSQPSYLSQHKKIHTGEKPYKCSECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGDKPYKCNDCGKAFRNKSYLSVHQKTHTEEKPYKCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECSECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLSVHHRMHTGEKPYKCNECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYTCYNCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYRCEECGKAFRTNSDFIVHLRMHTGEKPYKCSECGKAFRSSSSLTVHQRTHQREIQLI", "length": 796, "header": "tr|F1MGA9-1|A0AAA9TGZ1_BOVIN Computationally mapped isoform of Zinc finger protein 624 OS=Bos taurus OX=9913 GN=ZNF624 PE=3 SV=4 CANONICAL=A0AAA9TGZ1-1" }, "locus": { "chromosome": "19", "start_pos": 33101284, "end_pos": 33096357, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052640.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052640.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050398.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050398.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:104975043", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104975043", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9P2J8-1", "protein_name": "Zinc finger protein 624", "gene_name": "ZNF624", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQDSTLSREGKPEGEIMAAVFFSVGRLSPEVTQPDEDLHLQAEETQLVKESVTFKDVAIDFTLEEWRLMDPTQRNLHKDVMLENYRNLVSLGLAVSKPDMISHLENGKGPWVTVREISRIPYPDMEPKPATKKATRTKAISEDLSQEAILEKLTENGLWDSRMEGLWKWNDRILRLQNNQENHLSQRIIPLKKTPTSQRGFRFESILIPEPGIATEELHSRCQTQEENFTENLNLITDTHLGKIICKEMKGSKAIRQTSELTLGKKSNNKEKPYKCSTCEKAFHYRSLLIQHQRTHTKEKPYECNECGKTFSQPSYLSQHKKIHTGEKPYKCNECGKAFIASSSLMVHQRIHTKEKPYQCNVCGKSFSQCARLNQHQRIQTGEKPYKCSECGKAFSDKSKLARHQETHNGEKPYKCDDCGKAFRNKSYLSVHQKTHTEEKPYQCNECGKSFKNTTIFNVHQRIHTGEKPFRCNECGKAYRSNSSLIVHIRTHTGEKPYECNECGKAFNRIANFTEHQRIHTGEKPYKCNECGKAFINYSCLTVHHRMHTGEKPYKCTECGKAFMRSSSLIIHQRIHTEEKPYLCNECGESFRIKSHLTVHQRIHTGEKPYKCTDCERAFTKMVNLKEHQKIHTGVKPYKCYDCGKSFRTKSYLIVHQRTHTGEKPYKCNECEKAFTNTSQLTVHQRRHTGEKPYKCNECGKVFTSNSGFNTHQRTHTGEKPFKCNDCGKAFSQMVHVTEHQKIHSGEKPYKCDVCGKAFRRGSYLTVHWRTHTGEKPYTCKECGKGCITLSQLTLHQRIHTGERPYKCEECGKAFRTNSDFTVHLRMHTGEKPYKCNECGKAFRSSSSLTVHQRIHQRETQLI", "length": 865 }, "evidence": [ { "id": "A0AAA9TGZ1", "url": "https://omabrowser.org/oma/group/A0AAA9TGZ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 467, "end_pos": 469, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 259, "end_pos": 286, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ1" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 107, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 213, "end_pos": 215 }, { "start_pos": 410, "end_pos": 412 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 467, "end_pos": 469 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 662, "end_pos": 664 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFT1-1", "uniprot_ac": "A0AAA9TFT1", "uniprot_id": "A0AAA9TFT1_BOVIN", "mass": { "chemical_mass": 129125.0, "monoisotopic_mass": 129125.0 }, "refseq": { "ac": "XP_059746946", "name": "centrosomal protein of 128 kDa isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746946" }, "gene_names": [ { "name": "CEP128", "type": "recommended", "evidence": [ { "id": "A0AAA9TFT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ] }, { "name": "CEP128", "type": "synonym", "evidence": [ { "id": "XP_059746946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746946" } ] } ], "protein_names": [ { "name": "Centrosomal protein 128", "type": "synonym", "evidence": [ { "id": "A0AAA9TFT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 128 kDa isoform X5", "type": "synonym", "evidence": [ { "id": "XP_059746946", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746946" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP128", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1", "locus": { "chromosome": "10", "start_pos": 91775871, "end_pos": 92255522, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021708", "url": "https://www.ensembl.org/id/ENSBTAG00000021708" } ] } } ], "crossref": [ { "id": "A0AAA9TFT1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFT1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021708", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021708", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529746", "url": "https://www.ncbi.nlm.nih.gov/gene/529746", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ITSTLQX", "url": "https://omabrowser.org/oma/group/ITSTLQX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4L1", "url": "https://www.orthodb.org/?gene=A0A3Q1M4L1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BP64", "url": "https://www.orthodb.org/?gene=E1BP64", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46657", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46657", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46657:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46657:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059746946", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746946", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL84", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL84-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4L1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5F6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLT9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLT9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP64", "url": "https://www.uniprot.org/uniprotkb/E1BP64", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP64-1", "url": "https://www.uniprot.org/uniprotkb/E1BP64-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQDRVNALETSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1100, "header": "tr|A0AAA9TFT1-1|A0AAA9TFT1_BOVIN Isoform 1 of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0A3Q1LL84-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRGDWNAKVGSQETPGVTGKFGLGIRNEAGQRLIEFCQEKALVITNTSSNNTREDSIHGHHQMVNTEIRLIIFFAAKDGEALYSQQDQELTVAQTVNSFLPNSDLN", "length": 1037, "header": "tr|A0A3Q1LL84-1|A0AAA9TFT1_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 92039560, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068141.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068141.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057241.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057241.2" } ] } }, { "isoform_ac": "A0A3Q1LZW0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0A3Q1LZW0-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQDRVNALETKERVEIRTLEVSSRKSSSLQTVSIRTSPHTLRGAIRVYSGEELEVKAESSSIVRQGSEQEIKSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1162, "header": "tr|A0A3Q1LZW0-1|A0AAA9TFT1_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075442.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075442.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063205.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063205.2" } ] } }, { "isoform_ac": "A0A3Q1M4L1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0A3Q1M4L1-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQDRVNALETSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1045, "header": "tr|A0A3Q1M4L1-1|A0AAA9TFT1_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074636.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074636.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064751.1" } ] } }, { "isoform_ac": "A0AAA9S5F6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0AAA9S5F6-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRGSTTLRQGFCGVSDGKESACNAGDPGSTPGLGRSPGEGNGQSTLIFLPGEFREQWSLAACSPWGHKESERLSN", "length": 1006, "header": "tr|A0AAA9S5F6-1|A0AAA9TFT1_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91982077, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081178.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081178.1" } ] } }, { "isoform_ac": "A0AAA9TFT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0AAA9TFT1-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQDRVNALETSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1100, "header": "tr|A0AAA9TFT1-1|A0AAA9TFT1_BOVIN Isoform 1 of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121196.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121196.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095708.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095708.1" } ] } }, { "isoform_ac": "A0AAA9TI17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0AAA9TI17-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQDRVNALETSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1018, "header": "tr|A0AAA9TI17-1|A0AAA9TI17_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130390.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130390.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095847.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095847.1" } ] } }, { "isoform_ac": "A0ABI0NLT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#A0ABI0NLT9-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQPKLLFKMPPSEDASQTAMKNQKEAQFEEKADRVNALETSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1130, "header": "tr|A0ABI0NLT9-1|A0ABI0NLT9_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=1 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106165.1" } ] } }, { "isoform_ac": "E1BP64-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1/entry#E1BP64-1", "sequence": { "sequence": "MAESSSDSDHFRSRDRLRRWAASSVHREVRHRPTVDVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIGQLRSQRLSRNSGGRSISVTSLSTSDLDGVTVTESYRFPPTSPLKDYGDQQGVKRNRSKTGVRFVPETDDVGQFHAFHQSLRDLSSEQVRLGDDFNRELARRSRSDAATRRALEELTEKLNEAQKQDVVSDRVERRLQEIEKEMRTERELVERRQDQLGVISQQLQEALKKQEAKAEENEGEMKNKLRQTESEKSKLQQELELSRRLLNQSEGSRETLLHQVEELRTQLMKAEGDPKGLHHQVSQISRQQSSLQDEQGDDWRFRRGVEREDLEKQMSDLRVQLNFSAMASELEEVKRCLERKDKEKVHLAAQVENLTRELENREKQQLEMLDELTEIQKHFETCDAKHKRADLQITKLTQHAEEATKQAEQYLLEFQQSEGLRQEAEKRREELKLKAQESIRQWKLKHKKLERTLEKQSESLDQLSEKNNQILKEKDELKSQLYAALQQIENLRKELNDVLTKRALQEEELHCKEQKLSDVKSHQADLELEVKDSLDTIHRLEGELKKQNQIQSQLKAEKAHLEEQIAELKESQAKDKAQLLEMQEAIKDLSAIRADLANKLAEEQRARKEVLKNLSDLRTQAKSKDEETATIISQLKLERDVHQRELEDLTSSLQSVKTKHEHNIQELMKHFKKEKSEAENHIRTLKAESLEDKNMAQVQRCQLEKLKSQYDRLTEELTQNANENKKLKLKYQCLKDELEEKEKHITNEEEHRRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSRDSMDKLKVFSSSPDINYDPHRWLAESKTKLQWLCEELKERENREKSLRHQLMLCRQQLKNVTENKEAELQCLFEQIERQEQLLEEIHREKRDLLEETHRKDEEMESLQSTRVALDHLESVPEKLSLLEDFKGFRGSCSLSDRIDGRYSKYRVHRDSLQQCRDDTKHRVQSFRDDRNFAESSHAYGLDQSSCWQDHSRFLSSPRFSHLNSFTQRTVAPDSPSIKEDAPSLLMDERSPQPRKEEYESKNSKM", "length": 1092, "header": "tr|E1BP64-1|E1BP64_BOVIN Computationally mapped isoform of Centrosomal protein 128 OS=Bos taurus OX=9913 GN=CEP128 PE=4 SV=4 CANONICAL=A0AAA9TFT1-1" }, "locus": { "chromosome": "10", "start_pos": 92233804, "end_pos": 91776875, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061224.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061224.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053426.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053426.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A8E4-1", "protein_name": "Centrosomal protein 128", "gene_name": "Cep128", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAESSSDSDHFRYRDRLSRWAARSVQRGIGSRSTVDVTAKVNTITSTLQDTTRNLRQMDQMLGRYREYSLGQAGAVGQLKEDLEQSINQLRSQRLRRSSGGRSVSVTSLSASDFDGGAVAESLRFTPTSPLKDYDPQGIKRNRFRTGVRFVSETDDMVQLHTFHQSLRDLSSEQVRLGDDFNKELFRRSRSDAETKRVLEELTEKLNEAQKQDVVSDRVERRLQEIEREMRFERELVERRHDQLGLVSLKLQEALKKQEAKGDENEDIIKNKLRQTETEKSQLEQELEISRRLLSQSEGSRETLLHQVEELRTQLIKAEGDQRGLQHQVSCISKQPSSHQDDQGDDRRFRRGVEREKQNLEKQMADLRVQLNFNAMASELEEVKRCMDRKDLEKANLAAKIENLTRDLENREKQQLQMLDQLTEIQNHFETCEATRKQTDLQISELSQHAEEATKQAEHYLSEFQRSEALREEAEKRREDLKAKAQDAIRQWKLKHKKLERSMEKQGETLVQLTEKNNQVLKERDELKGQLCAALQQIENLRKELNDVLSKRALQDEELHCKEKKLNDIESHRAELELEVKNSLDTIHRLENELKRQSMIQNQIKAEKFHLEEEITELKESQSQDKVKLLEMQESIKDLSAVRADLANRLAEEERAKKAAFRDLSELTAQVKSKEEETVTAVTQLKLERDVHQRELEDLTSSLESVKVKHEQNIQELMRHFKNEKSEAESHIRTLEAESLEDKKVAKAHLGQLEKLKSKCEKLAEELTQNENENKKLKLKYQSLKEELEAKEKHISNEEEHLRRMEESRLQLKDQLLCLETEQESILGVIGKEIDEACKTFSRDSAEKLKVFTSGPQIHYDPHRWLAESKTKLQWLCEELKERESREKTLRRQLAASRQELRELTQHKESELLCLFEHIERQEQLLEEFHQEKRGLLEETQRKDEEVETLQPNLLFKLPPWEEASQSAVNSQNASHLEDKADRVNALQMSTRVALDHLESVPEKLSLLEDFKDFRGSSSLSVKSDGRYSKYSLHGDSAQQRRDDTKYRIKTFRDDRPFSAGSHAHGLDHSSSWQDHSRFLSTPQFSHFNCLPAFTKRTIASDPASIKGDAPGLPANGTSLQSKREEYESKKSKM", "length": 1134 }, "evidence": [ { "id": "A0AAA9TFT1", "url": "https://omabrowser.org/oma/group/A0AAA9TFT1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XJI2-1", "protein_name": "Centrosomal protein 128", "gene_name": "CEP128", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADSSSDSDFFRARIGRWPPLRRTSHNRARNYGAEEVTEKIHTLASTLQDTNRNLRHVDHLLGQYREYNKEQTEAIATLKETLEQSIGQLKSQRLTRNSGMRSASLSSLYPSDLDGETVSGVHHFVPTSPLRDYGDSQGNRHRRSRSASVRFVNEADDLNQLHSFHQSLRDLSSEQVRLGDDLSRELSRRNRADAEVRETLAELSEKLTESQRQETVSARVERRLQEIEQEMRAERQLVERRQDQLGQMSVQLQEALKKQDAKATETEELVKNKLVKYESEKKQLEQELEQSRKKLNQSESNREALLHQIEEIRSQLLRAEEDRADLQRQISHVVMYHQSSHDVREDERRIRTVAERYEREKQELEKHILELKAKLTHNTAMSEVEELKRRIEHKDKEKAQLVLQIEVLTSDLENREKQQQKMLDQLKELQSCYKASENGRRQTELQSAELAHQIEESTKEAERYLTEFKHSEALRLETEKRREDLKVRAQETIRQWKQKCKKLDREVEKQNEAISELMDKNNQALKEKDDLRNQLLSAIHQIENLQKELDDVLTKRAQQEEQLHCKEVKLDEMKSQQMSLEEEIKEFQGTVNKLENELKKQIFLQNQMQAEKEHLEQEIATSNSIHEKDRERLLEMQADVKNLSAVRVELMNRIAEEEKIKKELHKSLSELQKHQESKHEEMTSANRQLKMEREAHQQELADLRLELHNAKIKHERNIQELTKLLKQEKDDADAQIRMLKMELVEEKNIVKAQSQQLEKIKLECDKLTEELTQCEEGNTKLRRKFEFVKQELEKKDKQISDEEDHLRRMDKARLQFKVQLHHLEMEKESILTMIGTEIDAACEIFSRDSMEKFKAISLTPTVLNDPHRWLAETKTKLQWLCEEVKERENKEKKLRRYLLQSQQHLKHFTQLKESEHQSLFKQIKKQEQLLEEVHKEKRELLEKLHRREEEMGALQERIMSLEMSTRVALDHLESVPEKLSLLEDFKDNGESHCRREMIEERYTKYKEIVTSLQQQLEGSKQRVQQFKDGCSSHVEIDAEISGIQVAAASSSRRTQNNFLSSSLLSDSSSHMLRTVPSDTSAIKEDSVNVAITEMKQQAGRGKQ", "length": 1104 }, "evidence": [ { "id": "A0AAA9TFT1", "url": "https://omabrowser.org/oma/group/A0AAA9TFT1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6ZU80-2", "protein_name": "Centrosomal protein 128", "gene_name": "CEP128", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATMNGTSSQPKKEEYGS", "length": 1094 }, "evidence": [ { "id": "A0AAA9TFT1", "url": "https://omabrowser.org/oma/group/A0AAA9TFT1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BI22-1", "protein_name": "Centrosomal protein 128", "gene_name": "Cep128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAESSSDSDHVRYRDGLSRWATRSFQRGVGSHSTVDVTAKVNTITNTLQDTTRNLRHVDQMLGRYREYSTGQAGAVGQLKEDLEQSINQLRSQRLRRSSGGRSVSVTSLSASDLDGGAVTENLRFAPTSPLKDYDLQGIKRNRFRTGVRFVSETDDMVQLHTFHQSLRDLSSEQVRLGDDLNRELFRRSRSDAETKRVLEELTGKLNEVQKPDVVSDRVERRLQEIEREMRLERELVERRHDQLGLVSLKLQEALKKQEAKADENEDVIKRKLRQSETEKSQLEQELEISRRLLSQSESNRETLLHQVEELRTQLIKAEGDQRGLQHQVPCISKQPLSHQDDQGDDRRFRRGVEREKLSLEKQMADLRVQLNFNSMASELEEVKRCMERKDQEKATLAAQIENLTRDLENREKQQLQMLDQLTEIQNHFETCEANRKRTDLQLSELSQHAEEATKQAEHYLSEFQRSETLREEAEKRREDLKAKAQESIRQWKLKHKKLERSMEKQAETLVQLTEKNNQFIKERDELKSQLCAALQQIENLRKELNDVLSKRALQEEELHCKEKKLNDIESHQAELELEVKNSLDTIHRLENELKRQSKSQSQIKAEKIHLEEEITELKKSQSQDKVKLLEMQESIKDLSAIRADLANKLAEEEKAKKAVFRDLSELTAQVKSKEEETATAITQLKLERDVHQRELEDLSSSLESVKLKHEQNIQELMKHFKKEKSEAESHIRMLKAESLEDKNMAKAHLGQLEKLKSQCEKLTEELTHTENENKKLKLKYQSLKEELDKKEKYISTEEEHLRRMEESRLHLKDQLLCLETEQESILGVIGKEIDEACKTFSRDSLEKLKVLTSGPQLHYDPHRWLAESKTKLQWLCEELKERESRERSMRQQLAACRQELRELTEHKESELLCLFEHIERQEQLLEEFHQEKRGLLEETQRKDEEVETLQDRVNALQMSTRVALDHLESVPEKLSLLEDFKDFRGASSLSEKTDGRYSKYSLHGDSVQQRRDDTKPRIKSFRDDRPLSAGSHAHGLDHSSSCQDHSRFLSSPQFSHSLPVFTKRTIATDPASIEGDTTSLPANGTSPQSKKEEHEIKKYKK", "length": 1102 }, "evidence": [ { "id": "A0AAA9TFT1", "url": "https://omabrowser.org/oma/group/A0AAA9TFT1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0017015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "negative regulation of cilium assembly", "id": "GO:1902018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "positive regulation of protein localization", "id": "GO:1903829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "centriolar subdistal appendage", "id": "GO:0120103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" }, { "name": "sperm head-tail coupling apparatus", "id": "GO:0120212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120212", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFT1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 662, "end_pos": 664 }, { "start_pos": 902, "end_pos": 904 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFD0-1", "uniprot_ac": "A0AAA9TFD0", "uniprot_id": "A0AAA9TFD0_BOVIN", "mass": { "chemical_mass": 142133.0, "monoisotopic_mass": 142133.0 }, "refseq": {}, "gene_names": [ { "name": "SORBS1", "type": "recommended", "evidence": [ { "id": "A0AAA9TFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ] } ], "protein_names": [ { "name": "Sorbin and SH3 domain containing 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11919", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11922", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11922", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLW5", "url": "https://www.orthodb.org/?gene=A0A3Q1LLW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRD5", "url": "https://www.orthodb.org/?gene=A0A3Q1LRD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHH3", "url": "https://www.orthodb.org/?gene=A0A3Q1MHH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6RJF0", "url": "https://www.orthodb.org/?gene=F6RJF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167:SF64", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167:SF64", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-445355", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445355", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLW5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLW5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRD5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRD5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHH3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHH3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ63", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ63-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RJF0", "url": "https://www.uniprot.org/uniprotkb/F6RJF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RJF0-1", "url": "https://www.uniprot.org/uniprotkb/F6RJF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNSAGLVLPPDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDATSSSPAPPEVIVVPLYRVNTDRGHEGTDRPPASLGPHGPPVPAAAPAGSPLTFPTLDDFIPPHLQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQNSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQFPSHSKLLMPAPSSLPHPRRALSPEMHAVTSEWISLTVGVPSRRPLALTPPLPPLPEASIYSSDPLALFTRPSSSLPLNLPHSGWSDRSTPHSAVSLLALPPPHKAHSPAPGAQASFHVNGDSGTYVPPPGVLQDSFSQPWLGRSDRVISELSDAFSSQGKRQPWRDGNGARERKAEREAGERCPGGPAISKKSCLRPSDVVRCLSTEQRLTELHTPEESRPRHQPLGGPFSGREAERSELQRGGEPAARMGASQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1288, "header": "tr|A0AAA9TFD0-1|A0AAA9TFD0_BOVIN Isoform 1 of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=1 CANONICAL=A0AAA9TFD0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0A3Q1LLW5-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNSAGLVLPPDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQPSHHSLRAGPDLTESEKSYVQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 906, "header": "tr|A0A3Q1LLW5-1|A0AAA9TFD0_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=2 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072933.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072933.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057607.2" } ] } }, { "isoform_ac": "A0A3Q1LRD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0A3Q1LRD5-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTDEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSAHSRAVHSSSALGPGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQDRKSILLPSEKAQSCENLCVSGSLNDSRRGLPLPVGGSVENLLMRSRRDYDGRSSSTLSLQEFGAAARRPCPLSRKAGPQFTMLYRDMHHINRAGLFLGSGSSSSVRDLASHFERSGLALARGELGTSQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDLSGRLSKSPTPVLARSGLVSARSAESLLESTKLRPREVDGLSSGSIIYASPTCSRMVDSALGFRGLVPSEPLSACSDELDRCSNVSSDSREGSSGSVHGDFPKHRLNKCKGTCPASYTRFTTIRRHEQQQASRRPDWRPDPRGDKGTLLRNIYLMSPLPFRLKKPLQHPLRQPGPGDFSGQKPEPPSQPHRDEPPSGGRPSVPKRLSSRLTMARLSRISEPPQERPATPEVCPRAFSNGNSVPYSDQGLDRNNNPRGELGAPLGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQFPSHSKLLMPAPSSLPHPRRALSPEMHAVTSEWISLTVGVPSRRPLALTPPLPPLPEASIYSSDPLALFTRPSSSLPLNLPHSGWSDRSTPHSAVSLLALPPPHKAHSPAPGAQASFHVNGDSGTYVPPPGVLQDSFSQPWLGRSDRVISELSDAFSSQGKRQPWRDGNGARERKAEREAGERCPGGPAISKKSCLRPSDVVRCLSTEQRLTELHTPEESRPRHQPLGGPFSGREAERSELQRGGEPAARMGASQEAVCNEIINIAEKSVHYCSTVSHPLDFHHKVSPSDNKSSLIISQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1613, "header": "tr|A0A3Q1LRD5-1|A0AAA9TFD0_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=3 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067165.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067165.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062820.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062820.3" } ] } }, { "isoform_ac": "A0A3Q1MHH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0A3Q1MHH3-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNSAGLVLPPDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDATSSSPAPPEVIVVPLYRVNTDRGHEGTDRPPASLGPHGPPVPAAAPAGSPLTFPTLDDFIPPHLQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQFPSHSKLLMPAPSSLPHPRRALSPEMHAVTSEWISLTVGVPSRRPLALTPPLPPLPEASIYSSDPLALFTRPSSSLPLNLPHSGWSDRSTPHSAVSLLALPPPHKAHSPAPGAQASFHVNGDSGTYVPPPGVLQDSFSQPWLGRSDRVISELSDAFSSQGKRQPWRDGNGARERKAEREAGERCPGGPAISKKSCLRPSDVVRCLSTEQRLTELHTPEESRPRHQPLGGPFSGREAERSELQRGGEPAARMGASQPSHHSLRAGPDLTESEKSYVQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1262, "header": "tr|A0A3Q1MHH3-1|A0AAA9TFD0_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=2 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078922.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078922.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073704.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073704.2" } ] } }, { "isoform_ac": "A0A3Q1MJ63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0A3Q1MJ63-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNSAGLVLPPDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDATSSSPAPPEVIVVPLYRVNTDRGHEGTDRPPASLGPHGPPVPAAAPAGSPLTFPTLDDFIPPHLQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQNSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQPWRDGNGARERKAEREAGERCPGGPAISKKSCLRPSDVVRCLSTEQRLTELHTPEESRPRHQPLGGPFSGREAERSELQRGGEPAARMGASQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1104, "header": "tr|A0A3Q1MJ63-1|A0AAA9TFD0_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=1 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069154.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069154.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074379.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074379.2" } ] } }, { "isoform_ac": "A0AAA9TEP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0AAA9TEP2-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNRDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSAHSRAVHSSSALGPGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQDRKSILLPSEKAQSCENLCVSGSLNDSRRGLPLPVGGSVENLLMRSRRDYDGRSSSTLSLQEFGAAARRPCPLSRKAGPQFTMLYRDMHHINRAGLFLGSGSSSSVRDLASHFERSGLALARGELGTSQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDLSGRLSKSPTPVLARSGLVSARSAESLLESTKLRPREVDGLSSGSIIYASPTCSRMVDSALGFRGLVPSEPLSACSDELDRCSNVSSDSREGSSGSVHGDFPKHRLNKCKGTCPASYTRFTTIRRHEQQQASRRPDWRPDPRGDKGTLLRNIYLMSPLPFRLKKPLQHPLRQPGPGDFSGQKPEPPSQPHRDEPPSGGRPSVPKRLSSRLTMARLSRISEPPQERPATPEVCPRAFSNGNSVPYSDQGLDRNNNPRGELGAPLGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1291, "header": "tr|A0AAA9TEP2-1|A0AAA9TEP2_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=1 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063009.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063009.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096574.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096574.1" } ] } }, { "isoform_ac": "A0AAA9TFD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#A0AAA9TFD0-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNSAGLVLPPDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDATSSSPAPPEVIVVPLYRVNTDRGHEGTDRPPASLGPHGPPVPAAAPAGSPLTFPTLDDFIPPHLQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQNSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLETDLNLCQTELEADLEKTETLNKAPSTNLSQSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQFPSHSKLLMPAPSSLPHPRRALSPEMHAVTSEWISLTVGVPSRRPLALTPPLPPLPEASIYSSDPLALFTRPSSSLPLNLPHSGWSDRSTPHSAVSLLALPPPHKAHSPAPGAQASFHVNGDSGTYVPPPGVLQDSFSQPWLGRSDRVISELSDAFSSQGKRQPWRDGNGARERKAEREAGERCPGGPAISKKSCLRPSDVVRCLSTEQRLTELHTPEESRPRHQPLGGPFSGREAERSELQRGGEPAARMGASQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 1288, "header": "tr|A0AAA9TFD0-1|A0AAA9TFD0_BOVIN Isoform 1 of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=1 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110076.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110076.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097284.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097284.1" } ] } }, { "isoform_ac": "F6RJF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0/entry#F6RJF0-1", "sequence": { "sequence": "MSSECDAGASKAVVNGLAPGSNGQDKDMDPTRICTGKGAVTLRASSSYREIPSSSPVSPQETPKQERKTVLESENSSADEWRLSSNADANGNAQPSSLAAKGYRSVHPSLPSSKPQDATSSSPAPPEVIVVPLYRVNTDRGHEGTDRPPASLGPHGPPVPAAAPAGSPLTFPTLDDFIPPHLQRRSHHSQPASAPGSLPPASQTPPSFSPQPPLVPPVPEGLRRVSEPDLTGAVSSTDSSPLLNEVSSSHAGTDSQTFASVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRAGEQDSAPAQEKPTSPGRAAERKAKDDSRRVAKSAQDLSDVCMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSCIDGEKVVKRSATLPLPTRSSSLKSSPERTDWEPPDKKVDTRKYRAEPRSIYEYQPGKSSVLTNEKMSSAVSPTPDISSEPPGYVYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPTDYIDLPFSSSPSRSTTASPQQPQAQQRRVAPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL", "length": 815, "header": "tr|F6RJF0-1|F6RJF0_BOVIN Computationally mapped isoform of Sorbin and SH3 domain containing 1 OS=Bos taurus OX=9913 GN=SORBS1 PE=4 SV=2 CANONICAL=A0AAA9TFD0-1" }, "locus": { "chromosome": "26", "start_pos": 16941308, "end_pos": 16822693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003743.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003743.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003743.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003743.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 641, "start_aa": "Thr", "end_pos": 641, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr641", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-445355", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445355", "resource": "Reactome", "description": "Smooth Muscle Contraction" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "cell-substrate junction", "id": "GO:0030055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "insulin receptor binding", "id": "GO:0005158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "signaling receptor complex adaptor activity", "id": "GO:0030159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030159", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" }, { "name": "cell-substrate adhesion", "id": "GO:0031589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031589", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 631, "end_pos": 633, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 792, "end_pos": 851, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD0" }, { "id": "PS50831", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50831" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SoHo", "eco_id": "ECO_0000259", "start_pos": 365, "end_pos": 468, "start_aa": "Val", "end_aa": "Asp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 641 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 631, "end_pos": 633 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEG7-1", "uniprot_ac": "A0AAA9TEG7", "uniprot_id": "A0AAA9TEG7_BOVIN", "mass": { "chemical_mass": 53771.0, "monoisotopic_mass": 53771.0 }, "refseq": {}, "gene_names": [ { "name": "DEPTOR", "type": "recommended", "evidence": [ { "id": "A0AAA9TEG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ] } ], "protein_names": [ { "name": "DEP domain containing MTOR interacting protein", "type": "synonym", "evidence": [ { "id": "A0AAA9TEG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DEPTOR", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7", "locus": { "chromosome": "14", "start_pos": 81483827, "end_pos": 81286486, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015341", "url": "https://www.ensembl.org/id/ENSBTAG00000015341" } ] } } ], "crossref": [ { "id": "A0AAA9TEG7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEG7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04441", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04441", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04442", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04442", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23067", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23067", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M184", "url": "https://www.orthodb.org/?gene=A0A3Q1M184", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LP19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP19-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M184", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M184", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M184-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M184-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZX3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6N5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6N5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6N5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6N5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQLVVSVNGLNVLHVDYRTGYSGHRPTIKGMKANLQNSRLLGEVSQRQQ", "length": 480, "header": "tr|A0AAA9TEG7-1|A0AAA9TEG7_BOVIN Isoform 1 of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0A3Q1LP19-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKGSTEFSRATFPNLHYTAL", "length": 448, "header": "tr|A0A3Q1LP19-1|A0AAA9TEG7_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=3 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81404145, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080972.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080972.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058624.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058624.3" } ] } }, { "isoform_ac": "A0A3Q1M184-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0A3Q1M184-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKEI", "length": 432, "header": "tr|A0A3Q1M184-1|A0AAA9TEG7_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=2 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81419321, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083301.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083301.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061795.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061795.2" } ] } }, { "isoform_ac": "A0A3Q1MZX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0A3Q1MZX3-1", "sequence": { "sequence": "MAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHGQKLLTAIVWTVSDLVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKGYSGHRPTIKGMKANLQNSRLLGEVSQRQQ", "length": 430, "header": "tr|A0A3Q1MZX3-1|A0AAA9TEG7_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=2 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81448745, "end_pos": 81286820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082475.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082475.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061855.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061855.2" } ] } }, { "isoform_ac": "A0AAA9S3V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAA9S3V2-1", "sequence": { "sequence": "MEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQLVVSVNGLNVLHVDYRTRRRVWLSGCLCV", "length": 388, "header": "tr|A0AAA9S3V2-1|A0AAA9TEG7_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81443392, "end_pos": 81286907, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126244.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126244.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080617.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080617.1" } ] } }, { "isoform_ac": "A0AAA9SF87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAA9SF87-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKGYSGHRPTIKGMKANLQNSRLLGEVSQRQQ", "length": 460, "header": "tr|A0AAA9SF87-1|A0AAA9TEG7_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81448745, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134615.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134615.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082505.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082505.1" } ] } }, { "isoform_ac": "A0AAA9TEG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAA9TEG7-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQLVVSVNGLNVLHVDYRTGYSGHRPTIKGMKANLQNSRLLGEVSQRQQ", "length": 480, "header": "tr|A0AAA9TEG7-1|A0AAA9TEG7_BOVIN Isoform 1 of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81448745, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089915.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089915.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095323.1" } ] } }, { "isoform_ac": "A0AAA9TN45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAA9TN45-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKPHLRG", "length": 435, "header": "tr|A0AAA9TN45-1|A0AAA9TN45_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81415842, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105913.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105913.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097769.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097769.1" } ] } }, { "isoform_ac": "A0AAA9TQE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAA9TQE4-1", "sequence": { "sequence": "MAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKNPAGFPPVDLCDGLTLFQQSASTGLFWRERLYRKRGRENIYLASLLLNTGLSTSSGLIPIINTIPILQ", "length": 453, "header": "tr|A0AAA9TQE4-1|A0AAA9TQE4_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=2 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81428833, "end_pos": 81286820, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122606.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122606.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100592.2", "url": "https://www.ensembl.org/id/ENSBTAP00000100592.2" } ] } }, { "isoform_ac": "A0AAF6DLQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0AAF6DLQ3-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKELLVCFC", "length": 437, "header": "tr|A0AAF6DLQ3-1|A0AAF6DLQ3_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81402077, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020394.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020394.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020394.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020394.7" } ] } }, { "isoform_ac": "A0ABI0P6N5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7/entry#A0ABI0P6N5-1", "sequence": { "sequence": "MFPSWPRPRPRGARPRPHVGGLSGHRPPPPRGSQWRVSSAPPPAKMAGAVSVRAGWGSEPSPQRTTETEGAARAMEGVGGGDGGARQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAFVRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATAREEAEQLCQRLLEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLSEKSPSSQETHDSPFCLRKQGHDNRKSASFTSVSPSKEIKTASAARRSSMGSCGSSGYFSSSPTLSNSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQLVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC", "length": 472, "header": "tr|A0ABI0P6N5-1|A0ABI0P6N5_BOVIN Computationally mapped isoform of DEP domain containing MTOR interacting protein OS=Bos taurus OX=9913 GN=DEPTOR PE=4 SV=1 CANONICAL=A0AAA9TEG7-1" }, "locus": { "chromosome": "14", "start_pos": 81439666, "end_pos": 81286685, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147252.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147252.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107329.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107329.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "negative regulation of TORC2 signaling", "id": "GO:1903940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903940", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001236", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "negative regulation of cell size", "id": "GO:0045792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045792", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "phosphatidic acid binding", "id": "GO:0070300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEG7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEG7" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 99, "end_pos": 182, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFF5-1", "uniprot_ac": "A0AAA9TFF5", "uniprot_id": "A0AAA9TFF5_BOVIN", "mass": { "chemical_mass": 58028.0, "monoisotopic_mass": 58028.0 }, "refseq": {}, "gene_names": [ { "name": "MEPE", "type": "recommended", "evidence": [ { "id": "A0AAA9TFF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5" } ] } ], "protein_names": [ { "name": "Matrix extracellular phosphoglycoprotein", "type": "synonym", "evidence": [ { "id": "A0AAA9TFF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MEPE", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5", "locus": { "chromosome": "6", "start_pos": 36850100, "end_pos": 36864170, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007568", "url": "https://www.ensembl.org/id/ENSBTAG00000007568" } ] } } ], "crossref": [ { "id": "A0AAA9TFF5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFF5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007568", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007568", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613958", "url": "https://www.ncbi.nlm.nih.gov/gene/613958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PGRKNQT", "url": "https://omabrowser.org/oma/group/PGRKNQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR16510", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16510", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16510:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16510:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TFF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG36", "url": "https://www.uniprot.org/uniprotkb/E1BG36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG36-1", "url": "https://www.uniprot.org/uniprotkb/E1BG36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRIFCLELLLFSLTLAAPTLQPQAEKKKQDYVEEQRQEEKNKGIALPHSGKRSQEPAPKENIVLKKEEDLFLPRTNENNKSTKSQSLSGNKQSMNEDYIISSKENAHSDLKMSIYPESKGKHRAEDRDSAIRKLHSQEGYGAALIRNSMYHGMEPRTVTELLGGENKENKPRNVLGKIPADANYAKAPSQLKNHQRDSQAQNIPVKSKSTHLTQHNMDYLKQLPKVKKIPSDFEGSGYPDLQGRGDNDLSPFSGDGPPFKDISGKGDAIDPDRKGTDIQTELSIPSETETTSPDAKGPGYNEIPEKERNGRKTTGTRGKTAQEANTDVSLVEGSNDIIGGTDFKKLPGQEGNRVHGGSQDAHQGEIEFHYPHVPSKDQRKDGSRDGAEGTNYNEIPPNGKGSSRKGTQHSTRYQEPSKEKQRFPSKSEGQGQLIPPRGLDNEIKHEIGSHNGPNNEGTITTHSRKNHYVPHRQNNYAWNKGGSQSKGTWGYRNSHSNRRFRPPKKHDSSESSDSGSSSESDGD", "length": 523, "header": "tr|A0AAA9TFF5-1|A0AAA9TFF5_BOVIN Isoform 1 of Matrix extracellular phosphoglycoprotein OS=Bos taurus OX=9913 GN=MEPE PE=4 SV=1 CANONICAL=A0AAA9TFF5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFF5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5/entry#A0AAA9TFF5-1", "sequence": { "sequence": "MRIFCLELLLFSLTLAAPTLQPQAEKKKQDYVEEQRQEEKNKGIALPHSGKRSQEPAPKENIVLKKEEDLFLPRTNENNKSTKSQSLSGNKQSMNEDYIISSKENAHSDLKMSIYPESKGKHRAEDRDSAIRKLHSQEGYGAALIRNSMYHGMEPRTVTELLGGENKENKPRNVLGKIPADANYAKAPSQLKNHQRDSQAQNIPVKSKSTHLTQHNMDYLKQLPKVKKIPSDFEGSGYPDLQGRGDNDLSPFSGDGPPFKDISGKGDAIDPDRKGTDIQTELSIPSETETTSPDAKGPGYNEIPEKERNGRKTTGTRGKTAQEANTDVSLVEGSNDIIGGTDFKKLPGQEGNRVHGGSQDAHQGEIEFHYPHVPSKDQRKDGSRDGAEGTNYNEIPPNGKGSSRKGTQHSTRYQEPSKEKQRFPSKSEGQGQLIPPRGLDNEIKHEIGSHNGPNNEGTITTHSRKNHYVPHRQNNYAWNKGGSQSKGTWGYRNSHSNRRFRPPKKHDSSESSDSGSSSESDGD", "length": 523, "header": "tr|A0AAA9TFF5-1|A0AAA9TFF5_BOVIN Isoform 1 of Matrix extracellular phosphoglycoprotein OS=Bos taurus OX=9913 GN=MEPE PE=4 SV=1 CANONICAL=A0AAA9TFF5-1" }, "locus": { "chromosome": "6", "start_pos": 36861848, "end_pos": 36850480, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116014.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116014.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094899.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094899.1" } ] } }, { "isoform_ac": "E1BG36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5/entry#E1BG36-1", "sequence": { "sequence": "MRIFCLELLLFSLTLAAPTLQPQAEKKKQDYVEEQRITYKGRHEKHGYYMFKYVSTSSGRKNQTDMKEEKNKGIALPHSGKRSQEPAPKENIVLKKEEDLFLPRTNENNKSTKSQSLSGNKQSMNEDYIISSKENAHSDLKMSIYPESKGKHRAEDRDSAIRKLHSQEGYGAALIRNSMYHGMEPRTVTELLGGENKENKPRNVLGKIPADANYAKAPSQLKNHQRDSQAQNIPVKSKSTHLTQHNMDYLKQLPKVKKIPSDFEGSGYPDLQGRGDNDLSPFSGDGPPFKDISGKGDAIDPDRKGTDIQTELSIPSETETTSPDAKGPGYNEIPEKERNGRKTTGTRGKTAQEANTDVSLVEGSNDIIGGTDFKKLPGQEGNRVHGGSQDAHQGEIEFHYPHVPSKDQRKDGSRDGAEGTNYNEIPPNGKGSSRKGTQHSTRYQEPSKEKQRFPSKSEGQGQLIPPRGLDNEIKHEIGSHNGPNNEGTITTHSRKNHYVPHRQNNYAWNKGGSQSKGTWGYRNSHSNRRFRPPKKHDSSESSDSGSSSESDGD", "length": 553, "header": "tr|E1BG36-1|A0AAA9TFF5_BOVIN Computationally mapped isoform of Matrix extracellular phosphoglycoprotein OS=Bos taurus OX=9913 GN=MEPE PE=4 SV=3 CANONICAL=A0AAA9TFF5-1" }, "locus": { "chromosome": "6", "start_pos": 36861848, "end_pos": 36850480, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009958.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009958.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009958.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009958.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613958", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8K4L6-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "Mepe", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTPEGLMKMQAVSVGLLLFSMTWAAPMPNEDRSSCGNQDSIHKDLAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQEKRPQSVLSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHTRQTRRSTHYLTHLPQIKKTPSDLEGSGSPDLLVRGDNDVPPFSGDGQHFMHIPGKGGAGSGPESSTSRPLSGSSKAEVIDPHMSGLGSNEIPGREGHGGSAYATRDKAAQGAGSAGGSLVGGSNEITGSTNFRELPGKEGNRINAGSQNAHQGKVEFHYPQVASREKVKGGVEHAGRAGYNEIPKSSKGSSSKDAEESKGNQLTLTASQRFPGKGKSQGPALPSHSLSNEVKSEENHYVFHGQNNLTPNKGMSQRRGSWPSRRPNSHRRASTRQRDSSESSSSGSSSESHGD", "length": 441 }, "evidence": [ { "id": "A0AAA9TFF5", "url": "https://omabrowser.org/oma/group/A0AAA9TFF5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ES02-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "Mepe", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQAVSVGLFLFSMTWAAPKLNEDGSSGGNQGNIHLASVKPEPMVGKGTEGGRDAPLHLLDQNRQGATLLRNITQPVKSLVTGTEVQSDRNKEKKPQSVLSVIPTDVHNTNDYSEDTENQQRDLLLQNSPGQSKHTPRARRSTHYLTHLPQIRKILSDFEDSASPDLLVRGDNDVPPFSGDGQHFMHTPDRGGAVGSDPESSAGHPVSGSSNVEIVDPHTNGLGSNEIPGREGHIGGAYATRGKTAQGAGSADVSLVEGSNEITGSTKFRELPGKEGNRVDASSQNAHQGKVEFHYPQAPSKEKVKGGSREHTGKAGYNEIPKSSKGGASKDAEESKGNQVTLTESQRFPGKGKGQSSHSLGNEVKSEEDSSNSLSREGIAIAHRRTSHPTRNRGMSQRRGSWASRRPHPHRRVSTRQRDSSESSSSGSSSESSGD", "length": 435 }, "evidence": [ { "id": "A0AAA9TFF5", "url": "https://omabrowser.org/oma/group/A0AAA9TFF5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD", "length": 525 }, "evidence": [ { "id": "A0AAA9TFF5", "url": "https://omabrowser.org/oma/group/A0AAA9TFF5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix protein binding", "id": "GO:1990430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990430", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "biomineral tissue development", "id": "GO:0031214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031214", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFF5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFF5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": 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"OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BG38", "url": "https://www.orthodb.org/?gene=E1BG38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45872", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45872", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45872:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45872:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09128", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09128", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17838", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17838", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LFQ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSE0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MSE0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MSE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NB40", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NB40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NB40-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NB40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9M2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG38", "url": "https://www.uniprot.org/uniprotkb/E1BG38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BG38-1", "url": "https://www.uniprot.org/uniprotkb/E1BG38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGMLKDPDPAMGREASETENDKEFKRQQGEAEAREQEGKTSTEQESQRQRQREEHGQKHTEAKTETKRHTETQSRGGDTQVETDAGPPASPGRARKREPGHRARDRRARPRAPRRSPPRADTSPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQAPDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 1040, "header": "tr|A0AAA9TE39-1|A0AAA9TE39_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=1 CANONICAL=A0AAA9TE39-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0A3Q1LFQ5-1", "sequence": { "sequence": "MGERGETASDTDSPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQAPDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTERKWKRLSGRLGRSESLRVSDRRRPSRGSLGAKGRGGGRSRSDVDMDPSSATAVLGPTRRATPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 990, "header": "tr|A0A3Q1LFQ5-1|A0A3Q1LFQ5_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=2 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51339891, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066417.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066417.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057049.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057049.2" } ] } }, { "isoform_ac": "A0A3Q1MSE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0A3Q1MSE0-1", "sequence": { "sequence": "MEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 873, "header": "tr|A0A3Q1MSE0-1|A0AAA9TE39_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=2 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51338840, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071013.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071013.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072935.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072935.2" } ] } }, { "isoform_ac": "A0A3Q1NB40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0A3Q1NB40-1", "sequence": { "sequence": "MGRQRLRRARRGDGEQEKIGPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 935, "header": "tr|A0A3Q1NB40-1|A0AAA9TE39_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=2 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51339823, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075770.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075770.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068508.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068508.2" } ] } }, { "isoform_ac": "A0AAA9SF99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0AAA9SF99-1", "sequence": { "sequence": "MGMLKDPDPAMGREASETENDKEFKRQQGEAEAREQEGKTSTEQESQRQRQREEHGQKHTEAKTETKRHTETQSRGGDTQVETDAGPPASPGRARKREPGHRARDRRARPRAPRRSPPRADTSPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQAPDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 1007, "header": "tr|A0AAA9SF99-1|A0AAA9TE39_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=1 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51344050, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101439.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101439.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082525.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082525.1" } ] } }, { "isoform_ac": "A0AAA9T9M2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0AAA9T9M2-1", "sequence": { "sequence": "MSYLTAVPYFLGWEPERCQGPEGEKWLQGLLVPEGGGPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 952, "header": "tr|A0AAA9T9M2-1|A0AAA9TE39_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=1 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51339532, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096544.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096544.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093568.1" } ] } }, { "isoform_ac": "A0AAA9TE39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0AAA9TE39-1", "sequence": { "sequence": "MGMLKDPDPAMGREASETENDKEFKRQQGEAEAREQEGKTSTEQESQRQRQREEHGQKHTEAKTETKRHTETQSRGGDTQVETDAGPPASPGRARKREPGHRARDRRARPRAPRRSPPRADTSPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQAPDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 1040, "header": "tr|A0AAA9TE39-1|A0AAA9TE39_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=1 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51344050, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109779.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109779.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094440.1" } ] } }, { "isoform_ac": "A0AAA9TQG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#A0AAA9TQG9-1", "sequence": { "sequence": "MEFSRQEYWSGPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTESPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 926, "header": "tr|A0AAA9TQG9-1|A0AAA9TQG9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=1 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51341549, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099262.1" } ] } }, { "isoform_ac": "E1BG38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39/entry#E1BG38-1", "sequence": { "sequence": "MEFSSPAVPMEAEDVARGAAPGPPRPGLAPVSIIGAEDEDFEIELKTNPEEQNNQFQNLDQVKRRPAHLMALLQHVAMQFEPGPLLCCLHADMLGSLGPKEFKKAFIDFYHSFLDKHSILRVMVPPAVAFELDRTRPDLFPEDLQRQFVQEVVQSQQVAVVRQLEDFRSKKLMGMTPWEQELVQLGAWVARDRASYEARERHLAERQLTHLEEMQHTISNDEEKSAAVVNAISMYMRHLGVRTKSGDKKSGRNFFRKKMIGNRRSDEPTKTKKGLSSFLDAARWNRGEPQDFRHPKVEVDAEKPGLTERKGGQGAPSRDRNLGGPGQDTPGVSPHLLSGDSPDREPGVDALLEVGDPPPQGPASLDAPAPLESTEEAADTERKWKRLSGRLGRSESLRVSDRRRPSRGSLGAKGRGGGRSRSDVDMDPSSATAVLGPTRRATPEPGDEGEPGRSGLELEPEEPPGWRELVPQDILHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDVFYQPIADGGFYSQEELQNIFPSLDELIEVHSLFLDSLMKRRQDSGYLIKEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCTFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIEQNTEEPVEREKVERAAECCREILQHVNLAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKRLIYEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERFLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVIFTWDQEAQIYELVAQTVSERRIWCTLITETAGCLKVPSRTSRPKHRPGPSSTREPLLSSSENGNGSREMPPADGRMERLFNSLLPFCRQGLEGQLAAKALQKVLTLKQLLLPSEEDSGAGPPLEGDGVPGGSPLSPTQPQEIREELLSLEETIKQLEEVEEEFCRLRLLLSQLGENTVPQSGCT", "length": 980, "header": "tr|E1BG38-1|A0AAA9TE39_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 1 OS=Bos taurus OX=9913 GN=ARHGEF1 PE=4 SV=5 CANONICAL=A0AAA9TE39-1" }, "locus": { "chromosome": "18", "start_pos": 51341549, "end_pos": 51324004, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025175.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025175.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025175.8", "url": "https://www.ensembl.org/id/ENSBTAP00000025175.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "Rho-activating G protein-coupled receptor signaling pathway", "id": "GO:0160221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160221", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 920, "end_pos": 922, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { 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Gene", "id": "ENSBTAG00000004223", "url": "https://www.ensembl.org/id/ENSBTAG00000004223" } ] } } ], "crossref": [ { "id": "A0AAA9TH14", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TH14", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd01562", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01562", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525340", "url": "https://www.ncbi.nlm.nih.gov/gene/525340", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000634", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000634", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43050:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43050:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00291", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00291", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19169", "url": "https://www.rhea-db.org/rhea/19169", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T124", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T124", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T124-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T124-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLX8", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YLX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SAPGLWTQSGQDPSQLRRGDPDTLQPLRHLLGCCYSCSYSASAARAQPGNHDGRAARARAHPPPTLFPAPSRSPPQTTVAAQGGKAPNARSIAPAGTAGRGRRALRVRRGVVRKIRGALNAIRGLISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYGASIVYSEQSEESRENITKRIAEETEGIMVHPNQEPAVIAGQGTIAMEVLNQVPLVDALVVPVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPYPPETIADGIKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGVAVVLSQHFRTVPAEVKNICIVLSGGNVDLTSLTWVKKQDEKAAP", "length": 392, "header": "tr|A0AAA9TH14-1|A0AAA9TH14_BOVIN Isoform 1 of Serine racemase OS=Bos taurus OX=9913 GN=SRR PE=3 SV=2 CANONICAL=A0AAA9TH14-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T124-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14/entry#A0AAA9T124-1", "sequence": { "sequence": "MCDQYCISFADVEKAHINIRDFIHLTPVLTSSILNQITGRNLFFKCELFQKTGSFKIRGALNAIRGLISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYGASIVYSEQSEESRENITKRIAEETEGIMVHPNQEPAVIAGQGTIAMEVLNQVPLVDALVVPVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPYPPETIADGIKSSIGLNTWPIIRDLVDDVFTVTEDEIKGIFWTQGLNPHLCTADRFFTAEPPGKPYTNLWCSINDETQIHLLPSLITCIQIENKLAFRTFMSLLY", "length": 335, "header": "tr|A0AAA9T124-1|A0AAA9TH14_BOVIN Computationally mapped isoform of Serine racemase OS=Bos taurus OX=9913 GN=SRR PE=3 SV=1 CANONICAL=A0AAA9TH14-1" }, "locus": { "chromosome": "19", "start_pos": 23300736, "end_pos": 23292738, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100546.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100546.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092503.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092503.1" } ] } }, { "isoform_ac": "A0AAA9TGD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14/entry#A0AAA9TGD6-1", "sequence": { "sequence": "MKPTGRKQQRTMCDQYCISFADVEKAHINIRDFIHLTPVLTSSILNQITGRNLFFKCELFQKTGSFKIRGALNAIRGLISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYGASIVYSEQSEESRENITKRIAEETEGIMVHPNQEPAVIAGQGTIAMEVLNQVPLVDALVVPVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPYPPETIADGIKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGVAVVLSQHFRTVPAEVKNICIVLSGGNVDLTSLTWVKKQDEKAAP", "length": 345, "header": "tr|A0AAA9TGD6-1|A0AAA9TH14_BOVIN Computationally mapped isoform of Serine racemase OS=Bos taurus OX=9913 GN=SRR PE=3 SV=1 CANONICAL=A0AAA9TH14-1" }, "locus": { "chromosome": "19", "start_pos": 23297547, "end_pos": 23287421, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127471.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127471.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095936.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095936.1" } ] } }, { "isoform_ac": "A0AAA9TH14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14/entry#A0AAA9TH14-1", "sequence": { "sequence": "SAPGLWTQSGQDPSQLRRGDPDTLQPLRHLLGCCYSCSYSASAARAQPGNHDGRAARARAHPPPTLFPAPSRSPPQTTVAAQGGKAPNARSIAPAGTAGRGRRALRVRRGVVRKIRGALNAIRGLISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYGASIVYSEQSEESRENITKRIAEETEGIMVHPNQEPAVIAGQGTIAMEVLNQVPLVDALVVPVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPYPPETIADGIKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGVAVVLSQHFRTVPAEVKNICIVLSGGNVDLTSLTWVKKQDEKAAP", "length": 392, "header": "tr|A0AAA9TH14-1|A0AAA9TH14_BOVIN Isoform 1 of Serine racemase OS=Bos taurus OX=9913 GN=SRR PE=3 SV=2 CANONICAL=A0AAA9TH14-1" }, "locus": { "chromosome": "19", "start_pos": 23297547, "end_pos": 23280605, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134714.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134714.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096335.2", "url": "https://www.ensembl.org/id/ENSBTAP00000096335.2" } ] } }, { "isoform_ac": "A0AAF6YLX8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH14/entry#A0AAF6YLX8-1", "sequence": { "sequence": "MTDKTMCDQYCISFADVEKAHINIRDFIHLTPVLTSSILNQITGRNLFFKCELFQKTGSFKIRGALNAIRGLISAHPEEKPRAVVAHSSGNHGQALSFAARLEGIPAYVIVPETAPNCKKLAIQAYGASIVYSEQSEESRENITKRIAEETEGIMVHPNQEPAVIAGQGTIAMEVLNQVPLVDALVVPVGGGGMLAGIAVTVKALRPSVKVYAAEPLNADDCYQSKLKGELTPNPYPPETIADGIKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGVAVVLSQHFRTVPAEVKNICIVLSGGNVDLTSLTWVKKQDEKAAPQSVSV", "length": 344, "header": "tr|A0AAF6YLX8-1|A0AAF6YLX8_BOVIN Computationally mapped isoform of L-serine ammonia-lyase OS=Bos taurus OX=9913 GN=SRR PE=3 SV=1 CANONICAL=A0AAA9TH14-1" }, "locus": { "chromosome": "19", "start_pos": 23297565, "end_pos": 23279351, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005532.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005532.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005532.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005532.5" } ] } } ], "glycosylation": 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"Ensembl Peptide", "id": "ENSBTAP00000095305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095305.1" } ] } }, { "isoform_ac": "A0AAA9TJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ5/entry#A0AAA9TJA0-1", "sequence": { "sequence": "MMNLSTGIIFCFLILGVSSQGWGTFLKEAGQGAKDMWRAYQDMKEANYKGADKYFHARGNYDAAQRGPGGAWAAKVISNARETIQGITDPLFKGMTRDQVREDSKADQAANEWGRSGKDPNHFRPAGLPNKY", "length": 132, "header": "tr|A0AAA9TJA0-1|A0AAA9TGJ5_BOVIN Computationally mapped isoform of Mammary serum amyloid A3.2 OS=Bos taurus OX=9913 GN=M-SAA3.2 PE=3 SV=1 CANONICAL=A0AAA9TGJ5-1" }, "locus": { "chromosome": "29", "start_pos": 26505966, "end_pos": 26500623, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108922.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108922.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096312.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096312.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "high-density lipoprotein particle", "id": "GO:0034364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034364", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ5" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGJ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFD9-1", "uniprot_ac": "A0AAA9TFD9", "uniprot_id": "A0AAA9TFD9_BOVIN", "mass": { "chemical_mass": 126829.0, "monoisotopic_mass": 126829.0 }, "refseq": { "ac": "XP_059734667", "name": "coiled-coil domain-containing protein 150 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734667" }, "gene_names": [ { "name": "CCDC150", "type": "recommended", "evidence": [ { "id": "A0AAA9TFD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9" } ] }, { "name": "CCDC150", "type": "synonym", "evidence": [ { "id": "XP_059734667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734667" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 150", "type": "synonym", "evidence": [ { "id": "A0AAA9TFD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 150 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059734667", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734667" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC150", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9", "locus": { "chromosome": "2", "start_pos": 85328176, "end_pos": 85236678, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017695", "url": "https://www.ensembl.org/id/ENSBTAG00000017695" } ] } } ], "crossref": [ { "id": "A0AAA9TFD9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017695", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017695", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509158", "url": "https://www.ncbi.nlm.nih.gov/gene/509158", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509158", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509158", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TCRYNPG", "url": "https://omabrowser.org/oma/group/TCRYNPG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT85", "url": "https://www.orthodb.org/?gene=A0A3Q1LT85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCA6", "url": "https://www.orthodb.org/?gene=F1MCA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X8G4", "url": "https://www.orthodb.org/?gene=G3X8G4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35352:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35352:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_059734667", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734667", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB36", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN86", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCA6", "url": "https://www.uniprot.org/uniprotkb/F1MCA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCA6-1", "url": "https://www.uniprot.org/uniprotkb/F1MCA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X8G4", "url": "https://www.uniprot.org/uniprotkb/G3X8G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X8G4-1", "url": "https://www.uniprot.org/uniprotkb/G3X8G4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQSMGVTELDVHMETTMSRPVLSPTRINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGDKRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQTKVKQLEEQLHSLTETSSQNDHLRKLNKALEGKYAQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1087, "header": "tr|A0AAA9TFD9-1|A0AAA9TFD9_BOVIN Isoform 1 of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=1 CANONICAL=A0AAA9TFD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#A0A3Q1LT85-1", "sequence": { "sequence": "METTMSRPVLSPTRINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGDKRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQVDDVHTLFTIRVKSQTWAGSSTVFPLCALQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1068, "header": "tr|A0A3Q1LT85-1|A0AAA9TFD9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=2 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85246018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084170.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084170.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060524.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060524.2" } ] } }, { "isoform_ac": "A0AAA9RV47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#A0AAA9RV47-1", "sequence": { "sequence": "MPPRRRKSPERPASSKFLESYRPPVNSVKERTSSVGLPSVVPNPTRRVTFAPALTSVRSSQEIGDSRISLKTLLNAIKTMEGRLEGKIDILASRPLINDESPNFLNRDSVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 587, "header": "tr|A0AAA9RV47-1|A0AAA9TFD9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=1 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85303143, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089106.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089106.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077150.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077150.1" } ] } }, { "isoform_ac": "A0AAA9SB36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#A0AAA9SB36-1", "sequence": { "sequence": "METTMSRPVLSPTRINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGDKRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1009, "header": "tr|A0AAA9SB36-1|A0AAA9TFD9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=1 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85246018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133245.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133245.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083306.1" } ] } }, { "isoform_ac": "A0AAA9SN86-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#A0AAA9SN86-1", "sequence": { "sequence": "MLLLLSHFSYVRLCATPQTAAHQTPPSLGLSRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQTKVKQLEEQLHSLTETSSQNDHLRKLNKALEGKYAQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1053, "header": "tr|A0AAA9SN86-1|A0AAA9TFD9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=1 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85246617, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132993.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132993.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087781.1" } ] } }, { "isoform_ac": "A0AAA9TFD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#A0AAA9TFD9-1", "sequence": { "sequence": "MLQSMGVTELDVHMETTMSRPVLSPTRINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGDKRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQTKVKQLEEQLHSLTETSSQNDHLRKLNKALEGKYAQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1087, "header": "tr|A0AAA9TFD9-1|A0AAA9TFD9_BOVIN Isoform 1 of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=1 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85244189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105763.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105763.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097290.1" } ] } }, { "isoform_ac": "F1MCA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#F1MCA6-1", "sequence": { "sequence": "METTMSRPVLSPTRINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGDKRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKVDINALTCNVQTLEEKNKQLTDKIASLELEQASSDYHWLAQQQVENVLGKITDSKNKLAYEKGKLQTKVKQLEEQLHSLTETSSQNDHLRKLNKALEGKYAQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1074, "header": "tr|F1MCA6-1|A0AAA9TFD9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=3 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85246018, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012295.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012295.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012295.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012295.6" } ] } }, { "isoform_ac": "G3X8G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFD9/entry#G3X8G4-1", "sequence": { "sequence": "MLLLLSHFSYVRLCATPQTAAHQTPPSLGLSRGQLETPECSVSQNITRPIQNEIICSGKTNILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKDLNPQKTDFLKERLNTIQEEHSKDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTATLEIASETKKNAAIIEEELKTTKRKMNLKIQELRRQLSQEKHLRESLEKSGSALLLRIQEMEATVEVERKQVQILQENCIALRSSIQTTQELLAQEQQQKGELETASSQLKSDLVSRDDIISKLVEENKNIQMSFNKEHEGNAYLRSEIVSLHEASEKAQILNDQLTRKCSELSSMLQTVKMENTRIIADHQAILQEEQKMMTQTFQEQNLLLDAAHASITSELQTVQNEKTQLQMHLDHLILEHNQCIQKAQEAEKRATVQKELLESTIARLRGDLEASTQEKKSLLEEKDRLQKEVNKTEKEVAEEKCNLEKELAKNKLAQQQVENVLGKITDSKNKLAYEKGKLQTKVKQLEEQLHSLTETSSQNDHLRKLNKALEGKYAQVKSLLEKNEEELSQAVKGRDAALKESQKLKGDLETLEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDVAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLESKELERQNLETFKERMSEESKIEAELHAERIDALRKQFQIERETAKKAAQREVTEMKKALDEANFRSVEVSRTNRELRQKLTELEKLLNSSKEKIKNQRAQIKLHLSAKANNAQNVERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLARSQYDTSARNKQQELRLEAERKLRQELENRCQELEETIRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWREEDQDKRHNSMSNQSALHRWENKRNRLVPKKCHSEQERK", "length": 1015, "header": "tr|G3X8G4-1|G3X8G4_BOVIN Computationally mapped isoform of Coiled-coil domain containing 150 OS=Bos taurus OX=9913 GN=CCDC150 PE=4 SV=3 CANONICAL=A0AAA9TFD9-1" }, "locus": { "chromosome": "2", "start_pos": 85327922, "end_pos": 85246617, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063467.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063467.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056396.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056396.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509158", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509158", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M7H6-1", "protein_name": "Coiled-coil domain containing 150", "gene_name": "Ccdc150", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METNLLAAGRSYGLVDGLGVHMETTVCRPVLSPTHINATASETFTVLQQKMRIVEEQTSSLRDDLIMLGYGDRRCQLQTSDYLEDPVSQKVTSPIPNEVVCPESRGILWKNYEFLANRMCYLENLIQPLKMNIFHLQTEKDLNPQKAAFLKDQLNTIQGEHFKDLKLLQLEVMNLRQQLKVVKEEEDRAQDEVQRLTATLEIATETKKNAAVIEEELKTTKRKMNLKIQELRRQLAQEEHVRASLEKSASSMLLKVHEMESAVEAERQQVHTLQQKCIDLHSSMQTTQELLAQEQQKSNGLEMTASQLKSDLISRDNLIYKLVEENKSTQMSLKKEHEENTYLKSEVLSLQDISGKAQVLNDQLSKKCSELTSMLKAVKLENSRIIAEHHATLKVEQKMITETFQEQNLLLDTAHASITGELQTVQNDKAQLQMHLDHLILEHNQCLQKAQEAEKRTMAQKELLESTIARLRGELEASMQEKKSLLEKNEWFQREQVNKSEKGVAKEKCNLEKELAESKEDTNVLNQNLQILVEENKHLTDKMASLEHHKATSDYQGFAQQKVEKALEKITESKNKLAYEKGKLQIKVKQLEEQLHTFTETRLHNDHLQRQNKALEVKHAQIKSLLGKNEEELAEAVKCRDAALKESQKLKGDLEALEDRENKKVGNFQKQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERSLNQQRVQKLEAEVDQWQARMLIVEAQHSNEMEPLQKSLDVTREDNRKLAMSLEQALQTNGHLQSKLDHLQEKLESKERERQNLEAFKERVAEESKVEAELHAERIEALRKQFQTERETAKKVSHREVSELKKALDEANFRSVEVSRTNRELRHKATELEKVVNSNKEKLKNQRAQIRMHLSAKANSAQNMERMKQIEMELRQMEIIKDQYQKKNYEQSLSIQRFVSEMNALQKEMEMLAKSQYETSARNKQQELRLVAERKIRQELESRCKDLEDTIRHLRKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWLEENQDMRHNIATSQSVLHRWETKQNLGLMPKKYHSDTERKK", "length": 1101 }, "evidence": [ { "id": "A0AAA9TFD9", "url": "https://omabrowser.org/oma/group/A0AAA9TFD9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SN13-1", "protein_name": "Coiled-coil domain containing 150", "gene_name": "CCDC150", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDCAMHMETTVSRPVISPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGQLETPECLEQPVSQSIISPIQKEIICSGKTDILWKNCEFLVNRMCRLESLIQSLKMNIFRLQTEKELNPQKTAFLKDRLNTIQEEHSRDLKLLQLEVMNLRQQLRDVKEEEDKAQDEVQRLTVTLERASETKKNAAIIEEELKITKRKMNLKIQELRRQLSQEKHLRETLEKSGSAMLLKIQEMASTVEMERKQVQILQQNCIALRNSIQTTQELLAQEQQQKGELETATSQLKSDLVSRDDLISKLVEENKNLQMSFSKEHEENAYLRSEIMSLHEASEKAQALNEQLTRNCSELNSMLQTVRMENTRIIANHQAILQEEQKMMTKTFQEQNLLLDAAHASITSELQTVQNEKTQLQVHLDHLILEHNQCTQKAQDAEKRTAVQKELLESTIVRLRDELEASMQEKNSLLEEKERLQSKVNKAEKEVAQEKSNLEEELAKNKLARQQVENVLGKITESKNKLAYEKGKLQIKVKQLEEQLHSFTETSSQNDHLRKLNKALEGKYAQVKSILEKNEEELSRAVKGRDAALKESQKLKGDLEALEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERALNQQRVQKLEAEVDQWQARMLVVDAQHNSEMEPLQKALDIAREDNRKLAMSLEQALQTNNHLQTKLDHVQEKLENKEQELQNLETFKERMNEESKMEAELHAERIEALRKQFQTERETAKKAAQREMTELKKALDEANFRSVEVSRTNRELRQKLTELEKMLNSSKEKIKNQKAQIKLHLSAKANNVQNMERMKQIETELRQMELIKDQYQKKNYEQSLSIQKFVSEMTNLQKEMQLLAKSQYDTSARNKQQELRLELERKVRQELEHRCQELEETVRHLKKCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWLEEDQDKSHDNMSSQSALHRWENKQNLRLVPKKCHSELEKK", "length": 1046 }, "evidence": [ { "id": "A0AAA9TFD9", "url": "https://omabrowser.org/oma/group/A0AAA9TFD9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8CDI7-1", "protein_name": "Coiled-coil domain-containing protein 150", "gene_name": "Ccdc150", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METNLLPGGPSYGLLDESGVQMETTVCRPVLSPTHINGTASETFTVLQQKMRIVEEQTSSLRDDLIMLGYGDRRGQLETPNYLEDPASQKAISPIPNEVICPESPGNLWRNYEFLVNRMCYLENLIQSLKMNIFHLQTEKESNPQKTAFLNDQLNIIQGEHSKGLKLLQLEVMNLRQQLKVVKEEEDRAQDEMQRLTATLEIATETKKNAAVIEEELKTTKRKMNLKIQELRRQLAQEKLVRESLETSASSMLLKVQEMGSVVEAERQQVHALQEKCTALHSSMKTTQDLLAQEQRKNEDLGMTISQLKSDLNSRDNLICKLVEENKATQISLKKEHEENIYLKSEILSLQDVSGKAQVLNDQLSKKCSELTSMLQVVKMENSRIIAEHQAILKVEQKMITETFQEQNLLLDAAHASITGELQAVQNEKAQLQIHLDHLILEHNQCLQKSQEAEKRTVVQKELLESTIARLQGELKASLQEKKSLLEKNEWFQREVNKTEKEVAKEKCNLEKELAESKEDINVLNQNLQTLMEENKHLTNKMASLEHHKATSDYQGKVEKALEKITDSKNMLAYEKGKLQTKVKQLEAQLHTFAETMLQKDHLHKLNKALEVKYTQANSELSASKAYLEQTEAHLKEMKSILGKNEEELAQAVKCRDAALKESQKLKGDLKALEDRESKKVGNFQKQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERSLNQQRVQKLEAEVDQWQARMLIVEAQHGSEIEPLQKSLDITREDNRKLAMSLEQALQTNGHLQSKLDHLQEKLESKERERQSLEAFKEQVAEESKVEAELHAERIEALRKQFQTERETAKKASQREVSELKKALDEANFRSVEVSRANRELRHKATELEKVVNSNKEKLKNQRAQIKLHLSAKANNAQNMERMKQIEMELRQMEIIKDQYQKKNYEQSLSIQRFVSEMNTLQKEMELLTKSQYETSARNKQQELRLVAERKMRLELENRCKELEETIRHLKRCKEATENKLKEASVESEQITANLEEAHRWFKCRFDGLQLELTKNRLQRLPREDRWLEENQDMMHNVATSQSVLHRWETKQKYHSDTERKK", "length": 1110 }, "evidence": [ { "id": "A0AAA9TFD9", "url": "https://omabrowser.org/oma/group/A0AAA9TFD9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NCX0-1", "protein_name": "Coiled-coil domain-containing protein 150", "gene_name": "CCDC150", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDCKVHMETTVSRPVLSPTHINATASETFTVLQQRMRIVEEQTSSLRDDLIMLDFGEKRGYLEAPDCLEDLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLNPQKTAFLKDRLNAIQEEHSKDLKLLHLEVMNLRQQLRAVKEEEDKAQDEVQRLTATLKIASQTKKNAAIIEEELKTTKRKMNLKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRSEIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQEQNLLLDAAHASITNELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAVQKELLESTIARLRGELEASMQEKKSLLEEKERFQREVNKTEKEIVQERCNLEKELAKNKVDINTLTHNLQTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQRQLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERKIRQELENRCQELEETVRHLKKCKEATENTLKEASVESEQITANLEEAHRWFKHRFDGLQLELTKNRLQRPSGEDRWQEKDQDVKHDVMSNQSVLHRWERKQNLRPMPKKYHSEVQRK", "length": 1101 }, "evidence": [ { "id": "A0AAA9TFD9", "url": "https://omabrowser.org/oma/group/A0AAA9TFD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 1061, "end_pos": 1063, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" }, { "start_pos": 873, "end_pos": 875, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1061, "end_pos": 1063 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 486, "end_pos": 488 }, { "start_pos": 79, "end_pos": 81 }, { "start_pos": 873, "end_pos": 875 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFP3-1", "uniprot_ac": "A0AAA9TFP3", "uniprot_id": "A0AAA9TFP3_BOVIN", "mass": { "chemical_mass": 118434.0, "monoisotopic_mass": 118434.0 }, "refseq": { "ac": "XP_002697002", "name": "E3 ubiquitin-protein ligase PDZRN3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697002" }, "gene_names": [ { "name": "PDZRN3", "type": "recommended", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ] }, { "name": "PDZRN3", "type": "synonym", "evidence": [ { "id": "XP_002697002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697002" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase PDZRN3", "type": "recommended", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase PDZRN3", "type": "synonym", "evidence": [ { "id": "XP_002697002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697002" } ] }, { "name": "PDZ domain-containing RING finger protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase PDZRN3", "type": "synonym", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin cytoplasmic domain-associated protein 3", "type": "synonym", "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3#function" }, { "database": "UniProtKB", "id": "ARBA00053412", "url": "https://www.uniprot.org/uniprotkb/ARBA00053412#function" }, { "database": "UniProtKB", "id": "F1MRX7", "url": "https://www.uniprot.org/uniprotkb/F1MRX7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDZRN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3", "locus": { "chromosome": "22", "start_pos": 28387641, "end_pos": 28118157, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018644", "url": "https://www.ensembl.org/id/ENSBTAG00000018644" } ] } } ], "crossref": [ { "id": "A0AAA9TFP3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018644", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018644", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06715", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06715", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509083", "url": "https://www.ncbi.nlm.nih.gov/gene/509083", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509083", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509083", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HAGCGQL", "url": "https://omabrowser.org/oma/group/HAGCGQL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY75", "url": "https://www.orthodb.org/?gene=A0A3Q1LY75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MRX7", "url": "https://www.orthodb.org/?gene=F1MRX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15545", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15545", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15545:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15545:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002697002", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY75-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRX7", "url": "https://www.uniprot.org/uniprotkb/F1MRX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MRX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGQVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTQGEQRAGGHCCARALRAHNAALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAPPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKDGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQMVDMGTQTDITFEHIMALSKMSSPTPPVLDPYLLPEEHPSAHEYYDPNDYIAGIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWLDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAPAASPPLAGQRKLTCSQDTLGSGDLPFSNESFISADCADADYLGIPVDECERFRELLELKCQVKSAGPYGLYYPGSTLDASKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQFREPWMLHNSGFRNYNTSVDGRRRELADITELPEKSDKDSSSAYNTGESCRSTPLTLEMSPDNSLRRAAEGEGAAEAYGPSPKNLLSITEDSEGGSPNYSPSPKELDPSPAPESKERKPSDEGGGGSGSPTPGAKLGGSYLPPFPHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLNSANQSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSELKMGRYWSKEERKQHVVRAKEQRRRREFMMQSRLDCLKEQQGADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGAKSPDGTRVYNSFLSVTTV", "length": 1061, "header": "tr|A0AAA9TFP3-1|A0AAA9TFP3_BOVIN Isoform 1 of E3 ubiquitin-protein ligase PDZRN3 OS=Bos taurus OX=9913 GN=PDZRN3 PE=4 SV=1 CANONICAL=A0AAA9TFP3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#A0A3Q1LY75-1", "sequence": { "sequence": "MGCSLCSLQKPEEQYKLLYEVCQVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQMVDMGTQTDITFEHIMALSKMSSPTPPVLDPYLLPEEHPSAHEYYDPNDYIAGIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWLDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAPAASPPLAGQRKLTCSQDTLGSGDLPFSNESFISADCADADYLGIPVDECERFRELLELKCQVKSAGPYGLYYPGSTLDASKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQFREPWMLHNSGFRNYNTSVDGRRRELADITELPEKSDKDSSSAYNTGESCRSTPLTLEMSPDNSLRRAAEGEGAAEAYGPSPKNLLSITEDSEGGSPNYSPSPKELDPSPAPESKERKPSDEGGGGSGSPTPGAKLGGSYLPPFPHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLNSANQSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSELKMGRYWSKEERKQHVVRAKEQRRRREFMMQSRLDCLKEQQGADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGAKSPDGTRVYNSFLSVTTV", "length": 778, "header": "tr|A0A3Q1LY75-1|A0AAA9TFP3_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase PDZRN3 OS=Bos taurus OX=9913 GN=PDZRN3 PE=4 SV=1 CANONICAL=A0AAA9TFP3-1" }, "locus": { "chromosome": "22", "start_pos": 28386613, "end_pos": 28330405, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074541.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074541.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065692.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065692.1" } ] } }, { "isoform_ac": "A0AAA9TFP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#A0AAA9TFP3-1", "sequence": { "sequence": "MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGQVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTQGEQRAGGHCCARALRAHNAALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAPPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKDGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQMVDMGTQTDITFEHIMALSKMSSPTPPVLDPYLLPEEHPSAHEYYDPNDYIAGIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWLDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAPAASPPLAGQRKLTCSQDTLGSGDLPFSNESFISADCADADYLGIPVDECERFRELLELKCQVKSAGPYGLYYPGSTLDASKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQFREPWMLHNSGFRNYNTSVDGRRRELADITELPEKSDKDSSSAYNTGESCRSTPLTLEMSPDNSLRRAAEGEGAAEAYGPSPKNLLSITEDSEGGSPNYSPSPKELDPSPAPESKERKPSDEGGGGSGSPTPGAKLGGSYLPPFPHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLNSANQSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSELKMGRYWSKEERKQHVVRAKEQRRRREFMMQSRLDCLKEQQGADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGAKSPDGTRVYNSFLSVTTV", "length": 1061, "header": "tr|A0AAA9TFP3-1|A0AAA9TFP3_BOVIN Isoform 1 of E3 ubiquitin-protein ligase PDZRN3 OS=Bos taurus OX=9913 GN=PDZRN3 PE=4 SV=1 CANONICAL=A0AAA9TFP3-1" }, "locus": { "chromosome": "22", "start_pos": 28386613, "end_pos": 28118356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118171.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118171.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095824.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095824.1" } ] } }, { "isoform_ac": "F1MRX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3/entry#F1MRX7-1", "sequence": { "sequence": "MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGQVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTQGEQRAGGHCCARALRAHNAALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAPPPGGKDNQDGSSSEGIFVSKIVDSGPAAKDGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQMVDMGTQTDITFEHIMALSKMSSPTPPVLDPYLLPEEHPSAHEYYDPNDYIAGIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWLDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAPAASPPLAGQRKLTCSQDTLGSGDLPFSNESFISADCADADYLGIPVDECERFRELLELKCQVKSAGPYGLYYPGSTLDASKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQFREPWMLHNSGFRNYNTSVDGRRRELADITELPEKSDKDSSSAYNTGESCRSTPLTLEMSPDNSLRRAAEGEGAAEAYGPSPKNLLSITEDSEGGSPNYSPSPKELDPSPAPESKERKPSDEGGGGSGSPTPGAKLGGSYLPPFPHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLNSANQSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSELKMGRYWSKEERKQHVVRAKEQRRRREFMMQSRLDCLKEQQGADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGAKSPDGTRVYNSFLSVTTV", "length": 1032, "header": "tr|F1MRX7-1|A0AAA9TFP3_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase PDZRN3 OS=Bos taurus OX=9913 GN=PDZRN3 PE=4 SV=4 CANONICAL=A0AAA9TFP3-1" }, "locus": { "chromosome": "22", "start_pos": 28386613, "end_pos": 28118356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024807.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024807.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024807.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024807.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 377, "start_aa": "Thr", "end_pos": 377, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr377", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 845, "start_aa": "Thr", "end_pos": 845, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr845", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509083", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509083", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E7FDW2-1", "protein_name": "E3 ubiquitin-protein ligase PDZRN3-B", "gene_name": "pdzrn3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGFELDRFKGAVDPDFKCNLCNKVLEDPLTTPCGHVFCAGCVLPWVVQQSSCPVKCQRISTKELNHVLPLKNLILKLDIKCDNHARGCEKIVKLQHLAEHAEMCDYSPAKCRNKGCSEVLNLKDMDAHMRESCDYRAVGICESGCGLMLTHKEQKLDNHCCLKALKAHNGALQGKVVTLDKELKKQALKSTKREKSLLAQLSAVHNELQMTALKYQKKFTEYSARIDSLSKSLSPSPPCKGGETKSVTAILHRESGSLGFNIVGGRPCVDNKDGTSNEGIFVSKIVEKGAADKEGGLQIHDRIMEVNGKDLSKATHDQAVEAFRMAKEPIMVQVLRRAPRPKPTGPTGEGQVVDISTQTDITFQHIMALSKLPTSSTPVDVLEQYLLPEGHSPAHEYFDPNDFLEGMQHEIEREELEYEEVDLYRTNIHDKLGFTVCYRTDDEDETGIYVSEIDPNSIAAKDGRIREGDRIIQINGIEIQNREEAVALLTSEEHPNVCLLLARPEIQLDEGWMDDDRNDYLDDLHMDMLEQQHHQAMQFTASMLQQKKHEEDGGTTDTATLLSHHHEKDSGVGRTDDSTRNDESSEQENLADDQTSASTTLGSRRRLAYSQDTLGSGDLPFSSESFISADYADAEFLGDFPADECERFRELLELKCQMQSAGSSGTPDQSLLWPSGGQGGVGEEGVDKELELLNEELRSIELECLSIVRAHRMQQLREQCREQSWMLHNSGFRNYNTSVDARRHELADISELPEKSDKDSSSAYNTGESCRSTPLTLELSPDNSLRRGNESQAEAGASSSTSGPSRILKPLLSPVQEACSPTRGRPTLLKESEVGTQPEVRERKGGRHAHPQSPYKHAHIPAHAQHYQSYMQLIQQKSVEYAQSQMSLVSMCRDPVTSADLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQHAVRAKEQRQRREFMKQSRMDCQKELGVTTEDKKDVNIIELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSLLSVTTV", "length": 1053 }, "evidence": [ { "id": "A0AAA9TFP3", "url": "https://omabrowser.org/oma/group/A0AAA9TFP3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P68907-1", "protein_name": "E3 ubiquitin-protein ligase PDZRN3", "gene_name": "Pdzrn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFELDRFDGEVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPSRCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLLAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKISSPSPPVLGPYLLPEEHPSSHEYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGEDATASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDVDYLGIPEDECERFRELLELKCQVQSTSPYSLYYPSSPLDAAGKGDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANMEAYRPSPKNLLAITEDPEVSTPNYNPGAKELDPSQALEIKERRVSDGSRSPTASPKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSAEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV", "length": 1062 }, "evidence": [ { "id": "A0AAA9TFP3", "url": "https://omabrowser.org/oma/group/A0AAA9TFP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q69ZS0-1", "protein_name": "E3 ubiquitin-protein ligase PDZRN3", "gene_name": "Pdzrn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPASHDYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGEDATASANPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDVDYLGIPEDECERFRELLELKCQVQSASPYSLYYPSSPLDAAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANIEAYRPSPKNLLAITEDPEVSTPSYNPSAKELDPSQALEIKERRGSDGSRSPTASPKLGNAYLPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSVEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV", "length": 1063 }, "evidence": [ { "id": "A0AAA9TFP3", "url": "https://omabrowser.org/oma/group/A0AAA9TFP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UPQ7-1", "protein_name": "E3 ubiquitin-protein ligase PDZRN3", "gene_name": "PDZRN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAEGISCPSSEGAVGTTEAYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPTPSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV", "length": 1066 }, "evidence": [ { "id": "A0AAA9TFP3", "url": "https://omabrowser.org/oma/group/A0AAA9TFP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 730, "end_pos": 732, "annotation": "n_glycosylation_sequon" }, { "start_pos": 812, "end_pos": 814, "annotation": "n_glycosylation_sequon" }, { "start_pos": 908, "end_pos": 910, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 249, "end_pos": 339, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 18, "end_pos": 53, "start_aa": "Cys", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP3" }, { "id": "PS50145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRAF-type", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 139, "start_aa": "His", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 377, 845 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 495, "end_pos": 497 }, { "start_pos": 622, "end_pos": 624 }, { "start_pos": 730, "end_pos": 732 }, { "start_pos": 812, "end_pos": 814 }, { "start_pos": 908, "end_pos": 910 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { 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"id": "ENSBTAT00000098597.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098597.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078473.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078473.1" } ] } }, { "isoform_ac": "A0AAA9SSK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH57/entry#A0AAA9SSK6-1", "sequence": { "sequence": "MRLLVALLLLCVPGSLSLRGPSTVTGAVGDSLSVECRYEEEYSEFHKYWCRQPCFPLWQRTLQTSGPEVEVKSGRVSITDHPEDLAFTVTLESLTADDAGKYRCGVATMLKEEGLLGFLPDPFFQVQVIVSAGDRQLAGKSRGQDTVLHPPQFFTPPSITASSSNSSTWTSGSLSQQQGPLLGSAHFLLLVFLKVPLLLGMLGAALWVNRPQWAVCGETEPV", "length": 222, "header": "tr|A0AAA9SSK6-1|A0AAA9TH57_BOVIN Computationally mapped isoform of CD300H molecule OS=Bos taurus OX=9913 GN=CD300H PE=4 SV=1 CANONICAL=A0AAA9TH57-1" }, "locus": { "chromosome": "19", "start_pos": 56874629, "end_pos": 56866880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118515.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118515.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087107.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087107.1" } ] } }, { "isoform_ac": "A0AAA9TH57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH57/entry#A0AAA9TH57-1", "sequence": { "sequence": "MRLLVALLLLCVPGSLSLRGPSTVTGAVGDSLSVECRYEEEYSEFHKYWCRQPCFPLWQRTLQTSGPEVEVKSGRVSITDHPEDLAFTVTLESLTADDAGKYRCGVATMLKEEGLLGFLPDPFFQVQVIVSAGDRQLAGKSRGQDTVLHPPQFFTPPSITASSSNSSTWTSGSLSQQQGPLLGSAHFLLLVFLKVPLLLGMLGAALWVNRPLRSSADRQSQSIYENW", "length": 227, "header": "tr|A0AAA9TH57-1|A0AAA9TH57_BOVIN Isoform 1 of CD300H molecule OS=Bos taurus OX=9913 GN=CD300H PE=4 SV=1 CANONICAL=A0AAA9TH57-1" }, "locus": { "chromosome": "19", "start_pos": 56888395, "end_pos": 56866880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109038.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109038.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097569.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097569.1" } ] } }, { "isoform_ac": "A0AAA9TNB1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH57/entry#A0AAA9TNB1-1", "sequence": { "sequence": "MGGRTTCLLPALFLLVIPGSLSLRGPSTVTGAVGDSLSVECRYEEEYSEFHKYWCRQPCFPLWQRTLQTSGPEVEVKSGRVSITDHPEDLAFTVTLESLTADDAGKYRCGVATMLKEEGLLGFLPDPFFQVQVIVSAGDRQLAGKSRGQDTVLHPPQFFTPPSITASSSNSSTWTSGSLSQQQGPLLGSAHFLLLVFLKVPLLLGMLGAALWVNRPQWAVCGETEPV", "length": 227, "header": "tr|A0AAA9TNB1-1|A0AAA9TNB1_BOVIN Computationally mapped isoform of CD300H molecule OS=Bos taurus OX=9913 GN=CD300H PE=4 SV=1 CANONICAL=A0AAA9TH57-1" }, "locus": { "chromosome": "19", "start_pos": 56874629, "end_pos": 56839813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097238.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097238.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099845.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099845.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], 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"categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M9N4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9N4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9N4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV90-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQSLDICQLGYAYMITPQQKPWSLSL", "length": 338, "header": "tr|A0AAA9TFQ3-1|A0AAA9TFQ3_BOVIN Isoform 1 of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9N4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0A3Q1M9N4-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVSTIPTKDRLEGLLAFKEKRTPRYKGE", "length": 275, "header": "tr|A0A3Q1M9N4-1|A0AAA9TFQ3_BOVIN Computationally mapped isoform of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86686157, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068139.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068139.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067281.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067281.1" } ] } }, { "isoform_ac": "A0AAA9RTD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0AAA9RTD6-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRTPRYKGE", "length": 339, "header": "tr|A0AAA9RTD6-1|A0AAA9TFQ3_BOVIN Computationally mapped isoform of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86686157, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090248.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090248.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076194.1" } ] } }, { "isoform_ac": "A0AAA9S6Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0AAA9S6Z7-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQVCDKISLIQCRYTPYLLYKSTKLYIMSRFDSCLLQNHTNGLKLFVSFL", "length": 362, "header": "tr|A0AAA9S6Z7-1|A0AAA9TFQ3_BOVIN Computationally mapped isoform of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86682431, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096190.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096190.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077945.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077945.1" } ] } }, { "isoform_ac": "A0AAA9SJB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0AAA9SJB8-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIANLPVPTIAAIDGLALGGGLELALACDIRVAGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRTPRYKGE", "length": 320, "header": "tr|A0AAA9SJB8-1|A0AAA9TFQ3_BOVIN Computationally mapped isoform of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86686157, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134900.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134900.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082681.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082681.1" } ] } }, { "isoform_ac": "A0AAA9TFQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0AAA9TFQ3-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAMINEIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQSLDICQLGYAYMITPQQKPWSLSL", "length": 338, "header": "tr|A0AAA9TFQ3-1|A0AAA9TFQ3_BOVIN Isoform 1 of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86694252, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135118.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135118.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095682.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095682.1" } ] } }, { "isoform_ac": "A0AAA9TV90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3/entry#A0AAA9TV90-1", "sequence": { "sequence": "MAVAASAAPGALGTLQASRARLVAACCARLGPRWRLPGSWTCPRVDSTIWARGWTPAAGGAAWQRGYSAEVKTEDELRVRYLEEENRGIVVLGINRAYAKNSLSKNLIKMLSKAVDALKSDKKVRTIIVRSEVPGIFCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIFSARVLDGQEAKSVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTIPTKDRLEGLLAFKEKRTPRYKGE", "length": 310, "header": "tr|A0AAA9TV90-1|A0AAA9TV90_BOVIN Computationally mapped isoform of AU RNA binding methylglutaconyl-CoA hydratase OS=Bos taurus OX=9913 GN=AUH PE=1 SV=1 CANONICAL=A0AAA9TFQ3-1" }, "locus": { "chromosome": "8", "start_pos": 86686157, "end_pos": 86504014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091819.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091819.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102280.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" }, { "name": "L-leucine catabolic process", "id": "GO:0006552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006552", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "enoyl-CoA hydratase activity", "id": "GO:0004300", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004300", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" }, { "name": "methylglutaconyl-CoA hydratase activity", "id": "GO:0004490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004490", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" }, { "name": "lyase activity", "id": "GO:0016829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEA1-1", "uniprot_ac": "A0AAA9TEA1", "uniprot_id": "A0AAA9TEA1_BOVIN", "mass": { "chemical_mass": 51225.0, "monoisotopic_mass": 51225.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC7", "type": "recommended", "evidence": [ { "id": "A0AAA9TEA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 7", "type": "recommended", "evidence": [ { "id": "A0AAA9TEA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1", "locus": {} } ], "crossref": [ { "id": "A0AAA9TEA1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEA1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052951", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052951", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22035:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22035:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15368", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15368", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M9R8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9R8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9R8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPVKHLLTSSSKLVNVPELTFKKGLFNSPLSPKPKEKHSAKVVRDKLEPMVLKSPPTGESIVRYALPIPSSKTKELIAEDELIRKITKHLKMVVSSLEETYGYGTQNGEKAVVKPEHEELNFSVGDDLTSFLICCSQFATQLEAAAKEEHNILESLFKWFQRQVNQMEEISKDQTFSEAEFPTPDKTVSLSIAQIVKQVHKLEELKNRLKEGSKGNFRELLSKPFIKTHSTEEITDVSVTEPQTSPVTNQLNTMLKIFENQANKLERAMNEQLMLEAKYTQIQSDLQVLSEEKLMLENELQKLKSTEKTKATSERTKKVMKTEKKKDKGKSEDSEAKKSVGKELKVKENMPQVQKVAHALEIENKVLREQLKQALQEAERAKQQLAYFLNQEKEFLKSEAKTKTTTEMGTGKLKVKGEDSKYILLENETRKAVVGDSGGQKTNDKITYPQ", "length": 451, "header": "tr|A0AAA9TEA1-1|A0AAA9TEA1_BOVIN Isoform 1 of Coiled-coil domain containing 7 OS=Bos taurus OX=9913 GN=CCDC7 PE=4 SV=1 CANONICAL=A0AAA9TEA1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M9R8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1/entry#A0A3Q1M9R8-1", "sequence": { "sequence": "MKPVKHLLTSSSKLVNVPELTFKKGLFNSPLSPKPKEKHSAKVVRDKLEPMVLKSPPTGESIVRYALPIPSSKTKELIAEDELIRKITKHLKMVVSSLEETYGYGTQNGEKAVVKPEHEELNFSVGDDLTSFLICCSQFATQLEAAAKEEHNILESLFKWFQRQVNQMEESYE", "length": 173, "header": "tr|A0A3Q1M9R8-1|A0AAA9TEA1_BOVIN Computationally mapped isoform of Coiled-coil domain containing 7 OS=Bos taurus OX=9913 GN=CCDC7 PE=4 SV=2 CANONICAL=A0AAA9TEA1-1" }, "locus": { "chromosome": "13", "start_pos": 20303252, "end_pos": 20280513, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068935.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068935.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070703.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070703.2" } ] } }, { "isoform_ac": "A0AAA9RU85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1/entry#A0AAA9RU85-1", "sequence": { "sequence": "MKPVKHLLTSSSKLVNVPELTFKKGLFNSPLSPKPKEKHSAKVVRDKLEPMVLKSPPTGESIVRYALPIPSSKTKELIAEDELIRKITKHLKMVVSSLEETYGYGTQNGEKAVVKPEHEELNFSVGDDLTSFLICCSQFATQLEAAAKEEHNILESLFKWFQRQVNQMEEKLLL", "length": 174, "header": "tr|A0AAA9RU85-1|A0AAA9TEA1_BOVIN Computationally mapped isoform of Coiled-coil domain containing 7 OS=Bos taurus OX=9913 GN=CCDC7 PE=4 SV=1 CANONICAL=A0AAA9TEA1-1" }, "locus": { "chromosome": "13", "start_pos": 20303252, "end_pos": 20283594, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095188.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095188.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074625.1" } ] } }, { "isoform_ac": "A0AAA9TEA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEA1/entry#A0AAA9TEA1-1", "sequence": { "sequence": "MKPVKHLLTSSSKLVNVPELTFKKGLFNSPLSPKPKEKHSAKVVRDKLEPMVLKSPPTGESIVRYALPIPSSKTKELIAEDELIRKITKHLKMVVSSLEETYGYGTQNGEKAVVKPEHEELNFSVGDDLTSFLICCSQFATQLEAAAKEEHNILESLFKWFQRQVNQMEEISKDQTFSEAEFPTPDKTVSLSIAQIVKQVHKLEELKNRLKEGSKGNFRELLSKPFIKTHSTEEITDVSVTEPQTSPVTNQLNTMLKIFENQANKLERAMNEQLMLEAKYTQIQSDLQVLSEEKLMLENELQKLKSTEKTKATSERTKKVMKTEKKKDKGKSEDSEAKKSVGKELKVKENMPQVQKVAHALEIENKVLREQLKQALQEAERAKQQLAYFLNQEKEFLKSEAKTKTTTEMGTGKLKVKGEDSKYILLENETRKAVVGDSGGQKTNDKITYPQ", "length": 451, "header": "tr|A0AAA9TEA1-1|A0AAA9TEA1_BOVIN Isoform 1 of Coiled-coil domain containing 7 OS=Bos taurus OX=9913 GN=CCDC7 PE=4 SV=1 CANONICAL=A0AAA9TEA1-1" }, "locus": { "chromosome": "13", "start_pos": 20303252, "end_pos": 20257517, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092566.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092566.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096929.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096929.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 428, "end_pos": 430 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFU8-1", "uniprot_ac": "A0AAA9TFU8", "uniprot_id": "A0AAA9TFU8_BOVIN", "mass": { "chemical_mass": 138816.0, "monoisotopic_mass": 138816.0 }, "refseq": { "ac": "XP_003587965", "name": "erythroid differentiation-related factor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587965" }, "gene_names": [ { "name": "EDRF1", "type": "recommended", "evidence": [ { "id": "A0AAA9TFU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8" } ] }, { "name": "EDRF1", "type": "synonym", "evidence": [ { "id": "XP_003587965", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587965" } ] } ], "protein_names": [ { "name": "Erythroid differentiation regulatory factor 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TFU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8/entry#names_and_taxonomy" } ] }, { "name": "erythroid differentiation-related factor 1 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"ENSBTAG00000009439", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009439", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534065", "url": "https://www.ncbi.nlm.nih.gov/gene/534065", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR056582", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056582", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534065", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534065", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AFLYCNM", "url": "https://omabrowser.org/oma/group/AFLYCNM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BCZ3", "url": "https://www.orthodb.org/?gene=E1BCZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15000", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15000", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15000:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15000:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23723", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23723", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587965", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKJ7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ3", "url": "https://www.uniprot.org/uniprotkb/E1BCZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BCZ3-1", "url": "https://www.uniprot.org/uniprotkb/E1BCZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSKEAGAEAPPAGAAARGGLSLLSQGESEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSRKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSATEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLTPLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNASNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKTVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAGDEFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEQLRKQHRVLADLHYSKAGKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELVEEFEQPKSEETPPAADSSPSLNREEVTKLLSIFESRLSFLLLQSIKLLSSTKKKTSSILDEDIVLKTNKQVYSQLLRATANKNASLLERVDLLIHLLDQLACGRGSSAVVQ", "length": 1237, "header": "tr|A0AAA9TFU8-1|A0AAA9TFU8_BOVIN Isoform 1 of Erythroid differentiation regulatory factor 1 OS=Bos taurus OX=9913 GN=EDRF1 PE=4 SV=1 CANONICAL=A0AAA9TFU8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDE7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8/entry#A0A3Q1MDE7-1", "sequence": { "sequence": "MADSKEAGAEAPPAGAAARGGLSLLSQGESEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSRKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSATEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLTPLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNASNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKTVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAGDEFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEQLRKQHRVLADLHYSKAGKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELVEEFEQVGHNFPSKEQVCPNFMAAITIRSDPGAQKNSQPLCPLFPHPPATKQWD", "length": 1179, "header": "tr|A0A3Q1MDE7-1|A0AAA9TFU8_BOVIN Computationally mapped isoform of Erythroid differentiation regulatory factor 1 OS=Bos taurus OX=9913 GN=EDRF1 PE=4 SV=2 CANONICAL=A0AAA9TFU8-1" }, "locus": { "chromosome": "26", "start_pos": 45283789, "end_pos": 45252740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069731.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069731.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072170.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072170.2" } ] } }, { "isoform_ac": "A0AAA9TFU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8/entry#A0AAA9TFU8-1", "sequence": { "sequence": "MADSKEAGAEAPPAGAAARGGLSLLSQGESEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSRKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSATEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLTPLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNASNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKTVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAGDEFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEQLRKQHRVLADLHYSKAGKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELVEEFEQPKSEETPPAADSSPSLNREEVTKLLSIFESRLSFLLLQSIKLLSSTKKKTSSILDEDIVLKTNKQVYSQLLRATANKNASLLERVDLLIHLLDQLACGRGSSAVVQ", "length": 1237, "header": "tr|A0AAA9TFU8-1|A0AAA9TFU8_BOVIN Isoform 1 of Erythroid differentiation regulatory factor 1 OS=Bos taurus OX=9913 GN=EDRF1 PE=4 SV=1 CANONICAL=A0AAA9TFU8-1" }, "locus": { "chromosome": "26", "start_pos": 45285805, "end_pos": 45252740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131345.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131345.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095895.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095895.1" } ] } }, { "isoform_ac": "A0ABI0NKJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8/entry#A0ABI0NKJ7-1", "sequence": { "sequence": "MQVMRVKSDPGFPAHASPQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSRKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSATEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLTPLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNASNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKTVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAGDEFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEQLRKQHRVLADLHYSKAGKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELVEEFEQPKSEETPPAADSSPSLNREEVTKLLSIFESRLSFLLLQSIKLLSSTKKKTSILDEDIVLKTNKQVYSQLLRATANKNASLLERVDLLIHLLDQLACGRGSSAVVQ", "length": 1219, "header": "tr|A0ABI0NKJ7-1|A0ABI0NKJ7_BOVIN Computationally mapped isoform of Erythroid differentiation regulatory factor 1 OS=Bos taurus OX=9913 GN=EDRF1 PE=4 SV=1 CANONICAL=A0AAA9TFU8-1" }, "locus": { "chromosome": "26", "start_pos": 45285805, "end_pos": 45253167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153670.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153670.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105289.1" } ] } }, { "isoform_ac": "E1BCZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8/entry#E1BCZ3-1", "sequence": { "sequence": "MADSKEAGAEAPPAGAAARGGLSLLSQGESEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSRKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSATEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNASNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKTVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAGDEFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEQLRKQHRVLADLHYSKAGKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELVEEFEQPKSEETPPAADSSPSLNREEVTKLLSIFESRLSFLLLQSIKLLSSTKKKTSSILDEDIVLKTNKQVYSQLLRATANKNASLLERVDLLIHLLDQLACGRGSSAVVQ", "length": 1203, "header": "tr|E1BCZ3-1|A0AAA9TFU8_BOVIN Computationally mapped isoform of Erythroid differentiation regulatory factor 1 OS=Bos taurus OX=9913 GN=EDRF1 PE=4 SV=4 CANONICAL=A0AAA9TFU8-1" }, "locus": { "chromosome": "26", "start_pos": 45285805, "end_pos": 45252740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012421.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012421.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012421.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012421.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534065", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534065", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K4K6-1", "protein_name": "Erythroid differentiation regulatory factor 1", "gene_name": "Edrf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMGDPKEAGAEASPSGAAARGGLSLLSQTESEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSPAEQQESASSDQTHESEGASWPAPFEMPSSVSEDPSASSQGREPLEPSCIVGHVASAPKEQNLTTLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASSSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSDSPLNENSDESYSEEEEEEEMADSDENGSYGTSSDPADDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPSTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNCSGQSGMTPGSWQHKMKLQLILKSSKAYYILSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQGERVVSKSVSAAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRVCAQAHCGAEDEFKREFSPEEGLYYSKAVDYYLKALRSLGTRDMHPVVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKHCDVDSATARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMSSQNSNVGKLKTLSGALDIMVRTEHAFQLIRKELVEECDQPKNDEATPAADSSPNLNREEVIKLLSIFESRLSFLLLQSIKLMSSSKRKMSNTEDDAALQTNKQIYSQLLRATANRNSTLLERIEVVICLLEQLASGSSGSSGSAVP", "length": 1241 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0R4IK17-1", "protein_name": "Erythroid differentiation-related factor 1 isoform X1", "gene_name": "edrf1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVLNMSSQDKTDTDLRQEEEHSSSEDNKQEGVICLGNNEVKSRAVVKYSAAPPPSSYALLQEKTDLKLPPANWLRENAQLGPAGTTILGSSRKSKPFSSFGMAFDFIDCIGDDVDVVSDSENIKKLLKIPYSKSHVSMAVHRVGSTLLLDELDIQELFMRSSQTNDWTWLKEFYQRLIDQKWQRKKKSKEHWNEKAILSKFLYYSINSDGTAVSVPSDTEQTGDEGCGAGTDGPSWPATFSSSTTDSEESALPKEEQVDTYALGHVSSVPKEQNLPTLFNEGENSQGLRNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLMCNVPELVMCFHVNGIVQKYEMIKTEDIPNLENSTFSTRVVKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEEAAEEKCQNPFTLPVAVLLYKVASNMMLKKSQNRKIYGTIRTLLLNCIKLLDEDRHPQIIASAHYMLAELFQLDDVSEDEGNGESLRGGGSEDSYSDEDEEDEEEDEDERCSFSTASEPQHDSKAVAVIKSVGELSVPEKYKSTHQIRPNFAYPVSQDKEEKCRLVLSYVLKGLKAVDSSIKKESDLPAADPSTPIPLKYEERSPNGAREVEQEIALLLDRVGPCNEELKVPTRSGMLPGTWQHRMKLQLFLKASKAYYVLSDAATNLLKYGRALRYIKLALQCHDAYCSISGGLHAQVLLFHCQCLSLCGDVQLMLAQNASNRAAYLEEYSYQTKDDQEILHCLHRESSCQAFSMATDLALDPEYQLIVSCKCYEAAHDLLTSGVLKDQAQEQLGQVLKRLGNIRNEMGVFYMNQAAAMQAEKEGGRKKDCTNAKKTRSKSIIFFSGPDQKNPENQATMRRSVCVAEQELWKKSFSCFEKGMQYFSAISDSVNTALLLCNIGRLMRICAQAHCVITSEQSRGEFSPEETLYYNKAIDYYQRALKALGCRESHSAVWDSVNWELSTTYFTLATLLQDYAPLSRKAQEQIEREVTETMMKSLRYCDLQTESARQPLYQYRAATIHHRLASMYHSCYRNQVGDESDRKQHKALAEQHYSKAVRLFVNLSDAPCELLRTLLERVAFAEFTMAGQNSSAVKLKTLTGALEIMCETRHAFRLIHKELLEQQENITKAEEKPEEVPEGSESSSSSELNTEEVLKLIGIFEPSFSFLLLQVIKLSSASKRKLSGKEEEQVKIYKSVYSRLLRAEKSDPLIQRVSLFLELLDQLNPPSGSEEPRSSS", "length": 1270 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XFQ7-1", "protein_name": "Erythroid differentiation regulatory factor 1", "gene_name": "EDRF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAELCGLEAAASLRGDAEEPKQGSVLFLGGNEVKSSAVVKYSSAPPQAAFAWLQEKTDLKLPPANWLRESAKLGPAGTTVLGNNKKSTPFSSFGMAYDFIDSIGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSSSKQHEESAVPGESDEAGRASWPAPFEMPSSLSEDPGASNQGSVPLEPSYIVGHVASAPKEQNLTTLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEDIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMLKKNQNKKHYGTIRTLLLNCLKLLDNGRHPQIIASANYMLSELFQLDEPKKEDNTDFPINGNSDESYSEEEEEMPDSDENGSYSNSSDPPDDNKAVAIIKSVGELSVPEKYKSVHRIRPSCAFPVCHGAEERCRLVLSYVLEGLKSVDSSVKKESDLPAADPSTPIPLKYEDESTSGGPECLEKQMALFLDKMGSFQKDKHSSQSGMIPGSWQYKMKLQLILKSSKAYYVLSDAAMILQKYGRALRYIKLALQCHDTYCCLSASMLPEVLVFLCQCLTLCGDIQLMLAQNANNRAAYLEEYNYQTKEDQEILHSLHRESSCQVFAWATDLSTDLECQLSVSCKCYEAAYEILLFSNLKKQNPEQRVQVLKRMGNIRNEIGVFYMNQAAAVQTERVVSKNVSTTEQQLWKKSFSCFEKGIQNFESIDDATNAALLLCNTGRLMRICAQAHCATEGDFKREFSPEEALYYNKAIDYYLKALRSLGKREMHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDTVSPRQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAVRLFQLLKDAPCELLRVQLERVAFAEFQMASQNSSAGKLKTLFGALDIMAKTKCAFQLIRKDLAAESEQISKGESNAESLSPNESSTALNKEEVMKLLSIFESRMSFLLLQSIKLLTSTKKKTGGVNEEEVTLKTNKQVYSLLLRATANKSMTLLERIEVILNLLEQLSQNSEASNGGIQ", "length": 1229 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FS23-1", "protein_name": "Erythroid differentiation-related factor 1 isoform X1", "gene_name": "Edrf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGDPKEAGAEASPPGAAARGGLSLLSQAESEEPSSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSPAEQQESSSSDQTHDSEGASWPAPFEMPSSVSEDPSASSQGREPLEPSCIVGHVASAPKEQNLTTLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEENSDSPLNENSDESYSEEEEEMPDSDENGSYGTSSDPADDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPSTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNCSGQSGMTPGSWQHKMKLQLILKSSKAYYILSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQGERVVSKSVSAAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRVCAQAHCGAEDEFKREFSPEEGLYYSKAVDYYLKALRSLGTRDMHPVVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKHCDVDSATARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVKTDHAFQLIRKELVEECDQPKNNEATPAADSSPNLNQEEVIKLLSIFESRLSFLLLQSIKLLSSSKKKMSSNTEEDTVLQTNKQIYSQLLRATANRNSTLLERIDVIICLLEQLASGSSGSSGSAVA", "length": 1240 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1SDM8-1", "protein_name": "Erythroid differentiation regulatory factor 1", "gene_name": "EDRF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGDSKEAVAEAPPIGATARDGLSLLSQGETEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSAAEQQESSSSDQTNDSDGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLTTLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTVRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLVEPKKEESSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPNTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFNDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERAVSKSVSTAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRICAQAHCGAAEDFKREFSPEEGLYYNKAVDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRMLADLHYSKAVKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTKHAFQLIRKELLEEFDQPKSEETPPAAESPPGLNREEVLKLLSIFESRLSFLLLQSVKLLSSTKKKTSSNLEEDVVLKTNKQIYSQLLRATANKNASLLERIDLLLHLLEQLAHGAAGGAVQ", "length": 1236 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3B7T1-1", "protein_name": "Erythroid differentiation-related factor 1", "gene_name": "EDRF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDAKEAGAEGPPAGAAARGGLSLLSQGESEESSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVSSTAEQQESSSSDQTNDSEGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVASAPKEQNLITLFNDGEHSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCLKLLDKSRHPQIIASANYMLSELFQLDEPKKEENSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDSKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPSTPIPLKYEDESSRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFHYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQSERLVSKSVSAAEQQLWKKSFSCFEKGIHNFESIEDATNAALLLCNTGRLMRICAQAHCGAGDELKREFSPEEGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTEHAFQLIQKELIEEFGQPKSGDAAAAADASPSLNREEVMKLLSIFESRLSFLLLQSIKLLSSTKKKTSNNIEDDTILKTNKHIYSQLLRATANKTATLLERINVIVHLLGQLAAGSAASSNAVQ", "length": 1238 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6GQV7-1", "protein_name": "Erythroid differentiation-related factor 1", "gene_name": "Edrf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDPKEAGAEASPSGAAARGGLSLLSQADSEEPSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGAAQPVPSPAEQEESSSSQQTHESEGAAWPAPFEMPSSVSEDPSASSQGREPLEPSCIVGHVASAPKEQNLTTLFNDGENSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCVKLLDKSRHPQIIASANYMLSELFQLDEPKKEESSDSPLNENSDESYSEEEEEMADSDENGSYSTSSDPADDNKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADPSTPIPLKYEDESTRGGPEGLEKQMALFLDKMGSIQKGSCSGQSGMTPGSWQHKMKLQLILKSSKAYYILSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFNYQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAAALQGERVVSKSVSAAEQQLWKKSFSCFEKGIHNFESIDDATNAALLLCNTGRLMRVCAQAHCGAEDEFKREFSPEEGLYYSKAVDYYLKALRSLGTRDMHPIVWDSVNWELSTTYFTMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKHCDVDSATARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMSSQNSNVGKLKTLSGALDIMVRTEHAFQLIRKELVEECDQPKNDEATPAADSSPNLNREEVIKLLSIFESRLSFLLLQSIKLMSSSKRKMSSNAEEDIVLQTNKQIYSQLLRATANRNSTLLERIEVVICLLEQLASGSSRSSGSAVP", "length": 1239 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VSP0-1", "protein_name": "Erythroid differentiation-related factor 1", "gene_name": "Dmel\\CG6511", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEDRNEEIEPCRSIGPHELDVVKSQAVIKLSPVPVPAHFKRLECNTNLNLPPLNWLTTSHSSHGLHQALYQSAGFASFRLGQMFPDCVGEVDVVSDAENIKQLLKLPYSAKSAISMVVHKVGNTLLLDEFDIQKYLLRKADDDWKWLRSFILEHVLTYGDTQHNYCLKERSREALQTKNLLSKFLYHSLKQTGDELDYDVANTPTQLTSRKQGLPITGPVLPEPKIEENVPDPKSSHAFNRNVVWTFEDIRMLIGTDMPIFGGPNRPCISLRLRDAAQPINVLTGIDYWLDNLMCNVPEVVMCYHLDGIVQKYEIIKTEDLPYLENSQFSPQVVRNVAQNILAFLKANATKAGHTYWLFKGRNDDVVKLYDLTTLCQSQASEKSDEDPPEQQVNPFTVPVGMLLYSVARNMKNTLPHISPKAAGNIRALLDNCIKLLPKEQYPQIVSSSHYILSDLHVPAGIDPKAPKFEEVDSDDQSLYDDDEEEDEEDYEDDVLDYSSEKSYQSSEQSGGKANVAVRHICDALRDFKSHAKKSKPAPLIATTAERCSFSLEHISAGLSCLQYFNGSQEEKLKESETNAKQEEKRRILHEEQNPNMAKPCSAIPLPYEQLKVSQQPTQVVKKPNSKTQAKRSKSKELTTTTKSKSANASNQQMSAKFNTQHFGSWNVHLKLLLLEKACLTFATLAEHYYESRRYGSTLRSIELACRCQQVLNKYMANVVSQYSCLLGRAGDCFFQISKNWESIEEYIQQFGELDPSMDFIGDELAQELEGEEEELPSLAPSNNVEQVMLHSCKCYEQALEHAQKAESNELLRRLGNVRNELGLKYMYWAQEEYSELMKKKESTKDAGNDQTEDSPTADPSEPLYVKLTVNSYDCLRRGIEAFTAVKDNVNLAFLYCNIGRFMRLRAHLIMPNESAITLESQKAFYNEAFSYYVKAKDCLDTRKANPELWDLVHWELSTATFTLAKQLQDHSAADKSSLVDASKEVLELLQKSLRLCDVEHPGARQVLYSFRSGLIHKRIASFHYSQLRSHGCCDFSQLPKSTLQLCKYHYEKATQILESLKEVGDLLVVQLERISLHEFLAELSTHTAQKIKQMQAALEICLQCHLIFAHVIDTNSGQVADDEFAGHLTLFESRLQNALKTLTKLTLAGKDPKQLSKLYKRMYMETLTGKHGLGAQQSSTACLKHLHMLLARLRAMCETQLAPRPAVRVF", "length": 1211 }, "evidence": [ { "id": "A0AAA9TFU8", "url": "https://omabrowser.org/oma/group/A0AAA9TFU8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 548, "end_pos": 550, "annotation": "n_glycosylation_sequon" }, { "start_pos": 668, "end_pos": 670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 758, "end_pos": 760, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8" }, { "id": "PF23788", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23788" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EDRF1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 560, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU8" }, { "id": "PF23723", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23723" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EDRF1 TPR repeats region", "eco_id": "ECO_0000259", "start_pos": 836, "end_pos": 1227, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1209, "end_pos": 1211 }, { "start_pos": 238, "end_pos": 240 }, { "start_pos": 286, "end_pos": 288 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 413, "end_pos": 415 }, { "start_pos": 548, "end_pos": 550 }, { "start_pos": 668, "end_pos": 670 }, { "start_pos": 758, "end_pos": 760 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9THS1-1", "uniprot_ac": "A0AAA9THS1", "uniprot_id": "A0AAA9THS1_BOVIN", "mass": { "chemical_mass": 60093.0, "monoisotopic_mass": 60093.0 }, "refseq": {}, "gene_names": [ { "name": "NSMF", "type": "recommended", "evidence": [ { "id": "A0AAA9THS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ] } ], "protein_names": [ { "name": "NMDA receptor synaptonuclear signaling and neuronal migration factor", "type": "synonym", "evidence": [ { "id": "A0AAA9THS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NSMF", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1", "locus": { "chromosome": "11", "start_pos": 106433886, "end_pos": 106442690, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030247", "url": "https://www.ensembl.org/id/ENSBTAG00000030247" } ] } } ], "crossref": [ { "id": "A0AAA9THS1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9THS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030247", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030247", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615854", "url": "https://www.ncbi.nlm.nih.gov/gene/615854", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR033374", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033374", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058542", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 532, "header": "tr|A0AAA9THS1-1|A0AAA9THS1_BOVIN Isoform 1 of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=1 CANONICAL=A0AAA9THS1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MDI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#A0A3Q1MDI7-1", "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 502, "header": "tr|A0A3Q1MDI7-1|A0AAA9THS1_BOVIN Computationally mapped isoform of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=2 CANONICAL=A0AAA9THS1-1" }, "locus": { "chromosome": "11", "start_pos": 106442491, "end_pos": 106434890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074438.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074438.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066894.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066894.2" } ] } }, { "isoform_ac": "A0AAA9RTP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#A0AAA9RTP0-1", "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQANFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 507, "header": "tr|A0AAA9RTP0-1|A0AAA9THS1_BOVIN Computationally mapped isoform of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=1 CANONICAL=A0AAA9THS1-1" }, "locus": { "chromosome": "11", "start_pos": 106442491, "end_pos": 106434890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099070.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099070.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076395.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076395.1" } ] } }, { "isoform_ac": "A0AAA9RUW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#A0AAA9RUW9-1", "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAISNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 509, "header": "tr|A0AAA9RUW9-1|A0AAA9THS1_BOVIN Computationally mapped isoform of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=1 CANONICAL=A0AAA9THS1-1" }, "locus": { "chromosome": "11", "start_pos": 106442491, "end_pos": 106434890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098942.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098942.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074758.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074758.1" } ] } }, { "isoform_ac": "A0AAA9THS1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#A0AAA9THS1-1", "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 532, "header": "tr|A0AAA9THS1-1|A0AAA9THS1_BOVIN Isoform 1 of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=1 CANONICAL=A0AAA9THS1-1" }, "locus": { "chromosome": "11", "start_pos": 106442491, "end_pos": 106434890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097321.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097321.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098068.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098068.1" } ] } }, { "isoform_ac": "G3X6Z0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1/entry#G3X6Z0-1", "sequence": { "sequence": "MGAVASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGADHLLADACSGHDGSPEMQPAPQNKRRLSLISNGRYEGSLPEEAASGKPAGEGPQPRVYTISGEPALLPGPEAEAIELAVVKGRRQREQHPHHHSQPLRASPGGSHEDVSRPCQSWAGSRQGSKECPGCAQLAPSPSPQAFGVDQPPLPEAPGRRKKLERMYSVDRVSDDVPIRTWFPKENLFSFQTATTTMQAVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRVKAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLGEAFEDLDWETEKGLEAVACDTEGFVPPKVMLISSKVPKAEYIPTIIRRDDPAIIPILYDHEHATFEDILEEIEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLMSKVNPEPNVIHVMGCYVLGNPNGEKLFQNLRTLMTPYRVIFESPLELSAQGKQMIETYFDFRLYRLWKSRQHSKLLDFEDVL", "length": 530, "header": "tr|G3X6Z0-1|G3X6Z0_BOVIN Computationally mapped isoform of NMDA receptor synaptonuclear signaling and neuronal migration factor OS=Bos taurus OX=9913 GN=NSMF PE=4 SV=3 CANONICAL=A0AAA9THS1-1" }, "locus": { "chromosome": "11", "start_pos": 106442491, "end_pos": 106434890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016087.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016087.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016087.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016087.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of neuronal synaptic plasticity", "id": "GO:0048168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048168", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "positive regulation of neuron migration", "id": "GO:2001224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001224", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "regulation of neuron migration", "id": "GO:2001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001222", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" }, { "name": "cellular response to gonadotropin stimulus", "id": "GO:0071371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071371", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THS1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": 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"https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TGG0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DVVLTQTPLSLSIIPGEMASISCKSSQSLVHSDGKTYLNWIQYKPGQSPQGLIYQVSNRYSGVSDRFTGSGSGTDFTLTISRVQAEDAGVYYCYQGTEDPPTVIQPLTQTSLPGWLSCSKCSFSGELTADALSLC", "length": 135, "header": "tr|A0AAA9TGG0-1|A0AAA9TGG0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9TGG0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TGG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG0/entry#A0AAA9TGG0-1", "sequence": { "sequence": "DVVLTQTPLSLSIIPGEMASISCKSSQSLVHSDGKTYLNWIQYKPGQSPQGLIYQVSNRYSGVSDRFTGSGSGTDFTLTISRVQAEDAGVYYCYQGTEDPPTVIQPLTQTSLPGWLSCSKCSFSGELTADALSLC", "length": 135, "header": "tr|A0AAA9TGG0-1|A0AAA9TGG0_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN= PE=4 SV=2 CANONICAL=A0AAA9TGG0-1" }, "locus": { "chromosome": "11", "start_pos": 47251579, "end_pos": 47251175, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107748.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107748.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097645.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097645.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": {}, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TGG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGG0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 93, "start_aa": "Asp", "end_aa": "Cys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEQ8-1", "uniprot_ac": "A0AAA9TEQ8", "uniprot_id": "A0AAA9TEQ8_BOVIN", "mass": { "chemical_mass": 80625.0, "monoisotopic_mass": 80625.0 }, "refseq": {}, "gene_names": [ { "name": "NPHP1", "type": "recommended", "evidence": [ { "id": "A0AAA9TEQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ] } ], "protein_names": [ { "name": "Nephrocystin-1", "type": "recommended", "evidence": [ { "id": "A0AAA9TEQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPHP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8", "locus": { "chromosome": "11", "start_pos": 1762645, "end_pos": 1697163, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007675", "url": "https://www.ensembl.org/id/ENSBTAG00000007675" } ] } } ], "crossref": [ { "id": "A0AAA9TEQ8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007675", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007675", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11770", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11770", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505421", "url": "https://www.ncbi.nlm.nih.gov/gene/505421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15176:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15176:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MI92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MI92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMLKRKLQYFGHLMQRVDSLEKTLMLGGIGGRRRRGRQRMRWLDGITDSMAVDGLLFESRLKGALEASKRRDMYQRCIQLKQAIDENKNALQKLKKADEPAPVGNYYQKKEEEHNLLDKLTHQLQELAVSISRENVPETGALAEREEEENSDEEDEEEDDDEEESEESGGEDEETEEEEEEKQEGESQPEATSGEYIALGDFTAQQVGDLTFKKGEILCIIKKNSDGWWMAKNAKGNEGLIPKTYLEPYNKEGGQESSEGGSEEDTEVGDGTVDGAEVKQRTDSHWSAVRKAISEQINTVDVLTAMGAIPAGFRPSTLFQLLEEGNQFRASYFLQPELTPSQLAFRDLMWDAKTGSIRSRPSRVSLILTLWSCKMIPLPGVSIQVLSRHVRLCLFDGSEVLSNIHTVRATWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSSPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDATGIPIPAKTYKLFLNGGTPYEKGVEVDPSVSRRAHGSVFHQLMTMRRQPQLLVKLRSLNRRSRSTLSLLPETLIGSMCCVHLLIFYRQILGDVLLKDRMSLNSADLISNPVLATFPKLLEESDIMDALRSSWAEKESTLKRSEKGDRELLKAVFLLVYHDCALPLLHSALLPPSRWAEEETEAARWKGIADFLKQNQENEGALQVLLSPEGVHEPFDISEQTYDFLGERRKNVT", "length": 715, "header": "tr|A0AAA9TEQ8-1|A0AAA9TEQ8_BOVIN Isoform 1 of Nephrocystin-1 OS=Bos taurus OX=9913 GN=NPHP1 PE=3 SV=1 CANONICAL=A0AAA9TEQ8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MI92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8/entry#A0A3Q1MI92-1", "sequence": { "sequence": "MLARRQRDPLQSLQRRNQELKQQVDGLLFESRLKGALEASKRRDMYQRCIQLKQAIDENKNALQKLKKADEPAPVGNYYQKKEEEHNLLDKLTHQLQELAVSISRENVPETGALAEREEEENSDEEDEEEDDDEEESEESGGEDEETEEEEEEKQEGESQPEATSGEYIALGDFTAQQVGDLTFKKGEILCIIKKNSDGWWMAKNAKGNEGLIPKTYLEPYNKEGGQESSEGGSEEDTEVGDGTVDGAEVKQRTDSHWSAVRKAISEQINTVDVLTAMGAIPAGFRPSTLFQLLEEGNQFRASYFLQPELTPSQLAFRDLMWDAKTGSIRSRPSRVSLILTLWSCKMIPLPGVSIQVLSRHVRLCLFDGSEVLSNIHTVRATWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSSPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDATGIPIPAKTYKLFLNGGTPYEKGVEVDPSVSRRAHGSVFHQLMTMRRQPQLLVKLRSLNRRSRSTLSLLPETLIGSMCCVHLLIFYRQILGDVLLKDRMSLNSADLISNPVLATFPKLLEESDIMDALRSSWAEKESTLKRSEKGDRELLKAVFLLVYHDCALPLLHSALLPPSRWAEEETEAARWKGIADFLKQNQENEGALQVLLSPEGVHEPFDISEQTYDFLGERRKNVT", "length": 687, "header": "tr|A0A3Q1MI92-1|A0AAA9TEQ8_BOVIN Computationally mapped isoform of Nephrocystin-1 OS=Bos taurus OX=9913 GN=NPHP1 PE=3 SV=2 CANONICAL=A0AAA9TEQ8-1" }, "locus": { "chromosome": "11", "start_pos": 1761994, "end_pos": 1697189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082104.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082104.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068869.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068869.2" } ] } }, { "isoform_ac": "A0AAA9RY99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8/entry#A0AAA9RY99-1", "sequence": { "sequence": "MLARRQRDPLQSLQRRNQELKQQVDGLLFESRLKGALEASKRRDMYQRCIQLKQAIDENKNALQKLKKADEPAPVGNYYQKKEEEHNLLDKLTHQLQELAVSISRENVPEYAPPFFLPFK", "length": 120, "header": "tr|A0AAA9RY99-1|A0AAA9TEQ8_BOVIN Computationally mapped isoform of Nephrocystin-1 OS=Bos taurus OX=9913 GN=NPHP1 PE=3 SV=1 CANONICAL=A0AAA9TEQ8-1" }, "locus": { "chromosome": "11", "start_pos": 1708492, "end_pos": 1697189, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106795.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106795.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077583.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077583.1" } ] } }, { "isoform_ac": "A0AAA9TEQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8/entry#A0AAA9TEQ8-1", "sequence": { "sequence": "MMLKRKLQYFGHLMQRVDSLEKTLMLGGIGGRRRRGRQRMRWLDGITDSMAVDGLLFESRLKGALEASKRRDMYQRCIQLKQAIDENKNALQKLKKADEPAPVGNYYQKKEEEHNLLDKLTHQLQELAVSISRENVPETGALAEREEEENSDEEDEEEDDDEEESEESGGEDEETEEEEEEKQEGESQPEATSGEYIALGDFTAQQVGDLTFKKGEILCIIKKNSDGWWMAKNAKGNEGLIPKTYLEPYNKEGGQESSEGGSEEDTEVGDGTVDGAEVKQRTDSHWSAVRKAISEQINTVDVLTAMGAIPAGFRPSTLFQLLEEGNQFRASYFLQPELTPSQLAFRDLMWDAKTGSIRSRPSRVSLILTLWSCKMIPLPGVSIQVLSRHVRLCLFDGSEVLSNIHTVRATWQPKKPKTWTFSPQVTGILPCLLDGDCFIRSNSSSPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDATGIPIPAKTYKLFLNGGTPYEKGVEVDPSVSRRAHGSVFHQLMTMRRQPQLLVKLRSLNRRSRSTLSLLPETLIGSMCCVHLLIFYRQILGDVLLKDRMSLNSADLISNPVLATFPKLLEESDIMDALRSSWAEKESTLKRSEKGDRELLKAVFLLVYHDCALPLLHSALLPPSRWAEEETEAARWKGIADFLKQNQENEGALQVLLSPEGVHEPFDISEQTYDFLGERRKNVT", "length": 715, "header": "tr|A0AAA9TEQ8-1|A0AAA9TEQ8_BOVIN Isoform 1 of Nephrocystin-1 OS=Bos taurus OX=9913 GN=NPHP1 PE=3 SV=1 CANONICAL=A0AAA9TEQ8-1" }, "locus": { "chromosome": "11", "start_pos": 1761994, "end_pos": 1703001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105511.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105511.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096590.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096590.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" }, { "name": "positive regulation of bicellular tight junction assembly", "id": "GO:1903348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903348", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ8" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 191, "end_pos": 251, "start_aa": "Ala", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 442, "end_pos": 444 }, { "start_pos": 461, "end_pos": 463 }, { "start_pos": 713, "end_pos": 715 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEZ9-1", "uniprot_ac": "A0AAA9TEZ9", "uniprot_id": "A0AAA9TEZ9_BOVIN", "mass": { "chemical_mass": 61672.0, "monoisotopic_mass": 61672.0 }, "refseq": { "ac": "XP_005211122", "name": "connector enhancer of kinase suppressor of ras 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211122" }, "gene_names": [ { "name": "CNKSR3", "type": "recommended", "evidence": [ { "id": "A0AAA9TEZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ] }, { "name": "CNKSR3", "type": "synonym", "evidence": [ { "id": "XP_005211122", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211122" } ] } ], "protein_names": [ { "name": "CNKSR family member 3", "type": "synonym", "evidence": [ { "id": "A0AAA9TEZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#names_and_taxonomy" } ] }, { "name": "connector enhancer of kinase suppressor of ras 3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005211122", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211122" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CNKSR3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9", "locus": { "chromosome": "9", "start_pos": 91103523, "end_pos": 91213912, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012674", "url": "https://www.ensembl.org/id/ENSBTAG00000012674" } ] } } ], "crossref": [ { "id": "A0AAA9TEZ9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012674", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06748", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06748", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09511", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09511", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506781", "url": "https://www.ncbi.nlm.nih.gov/gene/506781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506781", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VTRWSPK", "url": "https://omabrowser.org/oma/group/VTRWSPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MR80", "url": "https://www.orthodb.org/?gene=A0A3Q1MR80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MVE4", "url": "https://www.orthodb.org/?gene=F1MVE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12844:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12844:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10534", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10534", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211122", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211122", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MR80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVE4", "url": "https://www.uniprot.org/uniprotkb/F1MVE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVE4-1", "url": "https://www.uniprot.org/uniprotkb/F1MVE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 554, "header": "tr|A0AAA9TEZ9-1|A0AAA9TEZ9_BOVIN Isoform 1 of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=1 CANONICAL=A0AAA9TEZ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MR80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#A0A3Q1MR80-1", "sequence": { "sequence": "MANKIVLLAWYQLCHRGQGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 555, "header": "tr|A0A3Q1MR80-1|A0AAA9TEZ9_BOVIN Computationally mapped isoform of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=2 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91149066, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075818.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075818.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074224.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074224.2" } ] } }, { "isoform_ac": "A0AAA9SNV8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#A0AAA9SNV8-1", "sequence": { "sequence": "MDLKEASLQGYGSSGHPWWLHGKGSACSAGVTEDAGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 572, "header": "tr|A0AAA9SNV8-1|A0AAA9TEZ9_BOVIN Computationally mapped isoform of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=1 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91184640, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098552.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098552.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085581.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085581.1" } ] } }, { "isoform_ac": "A0AAA9SYQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#A0AAA9SYQ9-1", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 540, "header": "tr|A0AAA9SYQ9-1|A0AAA9TEZ9_BOVIN Computationally mapped isoform of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=1 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91213713, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112698.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112698.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091592.1" } ] } }, { "isoform_ac": "A0AAA9TEZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#A0AAA9TEZ9-1", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 554, "header": "tr|A0AAA9TEZ9-1|A0AAA9TEZ9_BOVIN Isoform 1 of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=1 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91213713, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119051.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119051.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095416.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095416.1" } ] } }, { "isoform_ac": "A0AAA9THX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#A0AAA9THX0-1", "sequence": { "sequence": "MPPESSVLAATANAISPFAGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 556, "header": "tr|A0AAA9THX0-1|A0AAA9THX0_BOVIN Computationally mapped isoform of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=1 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91208624, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091072.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091072.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096695.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096695.1" } ] } }, { "isoform_ac": "F1MVE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9/entry#F1MVE4-1", "sequence": { "sequence": "MTGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLAVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWKPPLVQTSPPTTTTQSPDSTMDASLKKEKPAILDLYIPPPPSVPYSPREENGGSVYGFSKCKQPQPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPAKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKSEDALCRYFSNERIPPILEESSSPTYRFSRPGTERQLVRGADYIRGSRCYITSDLHSSATIPFPEEGTKKKAGSSAAKSSSPEPSLLVSWLTRLKLLTH", "length": 539, "header": "tr|F1MVE4-1|A0AAA9TEZ9_BOVIN Computationally mapped isoform of CNKSR family member 3 OS=Bos taurus OX=9913 GN=CNKSR3 PE=3 SV=2 CANONICAL=A0AAA9TEZ9-1" }, "locus": { "chromosome": "9", "start_pos": 91176854, "end_pos": 91104752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016838.6", "url": "https://www.ensembl.org/id/ENSBTAT00000016838.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016838.5", "url": "https://www.ensembl.org/id/ENSBTAP00000016838.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506781", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506781", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XMP1-1", "protein_name": "CNKSR family member 3", "gene_name": "CNKSR3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPVTKWSPKQVVDWTKGLDDCLQQYVHKFEREKINGEQLLQISHQDLEDMGITRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSNNLQNYICTRRKSSNYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRTPFTGIADFSSMKNRIIQLCLDLTTTVQKDCTVADMEDKVQTVSKALNGICDKAIRSTTDPLMSQCACLEEVHLTNIRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVAKLRENPAGVRLLLKKRPTGSFHFTPAPLKNLRWKPPLVQTSPPPTSTQSPESTMDTSVKKEKPAILDLYIPPPPAVPYSPRDEKGSFLYGGGSKPSHPLLGSKGAESPNSFLDQESRRRRFTIADSDQLPGYHMEANILPAKMREKTQSYGKPRPLSMPADGSWIGAAEPFSRPRAPGRKGKILGEDVLCRYFSNERIPPIIEESPSTQHPFSRPMSEKQLVRGMDYIRGSRCFMNTDLHNSATIPFQEEGAKKSSVTSSTKSSSAEPSLLVSWITRLKLLTH", "length": 559 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SB22-1", "protein_name": "CNKSR family member 3", "gene_name": "CNKSR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISGRRKSPAYDGNTSHKPPNEFLTSVVELIGAAKALLAWLDRTPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLTVVKVLNGICDKTIRSATDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTSSFNFTPAPLKNLRWRPPLVQTSPLPTTTQSPDSTMDASLKKEKPAILDLYIPPPPAIPYSPREENGSAGYGGVSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNVLPTKMREKTPSYGKPRPLSMPADASWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSAPPYRFSRPPTERQLVRGADYIRGSRCYLSSDLHSSATIPFQEEGTKKKAGPSAARSSSAEPSLLVSWFTRLKLLTH", "length": 555 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GU34-1", "protein_name": "Connector enhancer of kinase suppressor of ras 3 isoform X1", "gene_name": "Cnksr3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLALKLRASSHNLQNYISSRRKSSAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCLVAEMEDKVLNVVKVLNGICDKTMRSTSDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENRSFAYGGSSKGKQQLSGRKGSESPNSFLDQESQRRRFTIADSDQLPAYSVGTNVLPTKMRKKTPSYGKPRPLSMPADGNWMGIVDPFARPRGPGRKGDDALCRYFSNERITPIIEESASPVYRFSRPTTERHLVRGADYIRGSRCYLNSDLHSSATIPFQEEGPKKKSATSSAKASSGEPSLLVSWLTRLKLLTH", "length": 555 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5SGD7-1", "protein_name": "Connector enhancer of kinase suppressor of ras 3", "gene_name": "Cnksr3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFSYRGHTKSKQPLPGRKGSESPNSFLDQESQRRRFTITDSDQLPGYSVGTNILPIKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGHGRKGEDALCRYFSNERITPIIEESASPVYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGPKKKSASSSAKASSGEPSLLVSWLTRLKLLTH", "length": 555 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P9H4-1", "protein_name": "Connector enhancer of kinase suppressor of ras 3", "gene_name": "CNKSR3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH", "length": 555 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMA3-1", "protein_name": "Connector enhancer of kinase suppressor of ras 3", "gene_name": "Cnksr3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDTMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLIAEMEDKVLNVVKVLNGICDKTMRSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVRKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFGYRGHSKSKQPLPVRKGSESPNSFLDQESQRRRFTIADSDQLPGYSVETNVLPTKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGNGRKGEDALCRYFSNERITPITEESASPMYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGSKKKSASSSAKASSGEPSLLVSWLTRLKLLTH", "length": 555 }, "evidence": [ { "id": "A0AAA9TEZ9", "url": "https://omabrowser.org/oma/group/A0AAA9TEZ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "pmid": "" }, { "name": "enzyme-linked receptor protein signaling pathway", "id": "GO:0007167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007167", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" }, { "id": "PS51290", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51290" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CRIC", "eco_id": "ECO_0000259", "start_pos": 80, "end_pos": 174, "start_aa": "Asn", "end_aa": "Ala", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TEZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 211, "end_pos": 293, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TEZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEZ9" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 72, "start_aa": "Trp", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 298, "end_pos": 300 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TH50-1", "uniprot_ac": "A0AAA9TH50", "uniprot_id": "A0AAA9TH50_BOVIN", "mass": { "chemical_mass": 25659.0, "monoisotopic_mass": 25659.0 }, "refseq": { "ac": "XP_024846819", "name": "coiled-coil domain-containing protein 71L", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846819" }, "gene_names": [ { "name": "CCDC71L", "type": "recommended", "evidence": [ { "id": "A0AAA9TH50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH50" } ] }, { "name": "CCDC71L", "type": "synonym", "evidence": [ { "id": "XP_024846819", "database": "RefSeq", "url": 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"Protein" ] }, { "id": "A0A3Q1MRE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRSVKRRRRRPPAAPAAAARGGGFRLGGGAGLEAREEKVVYSRSQLSLADSTKALGDAFKLFMPRSTEFMSSDAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPEPPGGPTARGPTRRPAPSAAARRRRRGARAPAARRRKLPPPPPPVPEESCPVKPAAPEPCFGGRTLEEIWRAATPTLTTFPTIRVGSDVWGERSLAAARRKARQILRVNLEPVVRLRRFPVPRA", "length": 233, "header": "tr|A0AAA9TH50-1|A0AAA9TH50_BOVIN Isoform 1 of Coiled-coil domain containing 71 like OS=Bos taurus OX=9913 GN=CCDC71L PE=4 SV=1 CANONICAL=A0AAA9TH50-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MRE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH50/entry#A0A3Q1MRE2-1", "sequence": { "sequence": "MTKPRGGRRPPSCTGRQDLHPRPPPSEGEGQRRRRRRPPAAPAAAARGGGFRLGGGAGLEAREEKVVYSRSQLSLADSTKALGDAFKLFMPRSTEFMSSDAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPEPPGGPTARGPTRRPAPSAAARRRRRGARAPAARRRKLPPPPPPVPEESCPVKPAAPEPCFGGRTLEEIWRAATPTLTTFPTIRVGSDVWGERSLAAARRKARQILRVNLEPVVRLRRFPVPRA", "length": 259, "header": "tr|A0A3Q1MRE2-1|A0AAA9TH50_BOVIN Computationally mapped isoform of Coiled-coil domain containing 71 like OS=Bos taurus OX=9913 GN=CCDC71L PE=4 SV=2 CANONICAL=A0AAA9TH50-1" }, "locus": { "chromosome": "4", "start_pos": 47814521, "end_pos": 47813592, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085779.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085779.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074327.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074327.2" } ] } }, { "isoform_ac": "A0AAA9TH50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH50/entry#A0AAA9TH50-1", "sequence": { "sequence": "MRRSVKRRRRRPPAAPAAAARGGGFRLGGGAGLEAREEKVVYSRSQLSLADSTKALGDAFKLFMPRSTEFMSSDAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPEPPGGPTARGPTRRPAPSAAARRRRRGARAPAARRRKLPPPPPPVPEESCPVKPAAPEPCFGGRTLEEIWRAATPTLTTFPTIRVGSDVWGERSLAAARRKARQILRVNLEPVVRLRRFPVPRA", "length": 233, "header": "tr|A0AAA9TH50-1|A0AAA9TH50_BOVIN Isoform 1 of Coiled-coil domain containing 71 like OS=Bos taurus OX=9913 GN=CCDC71L PE=4 SV=1 CANONICAL=A0AAA9TH50-1" }, "locus": { "chromosome": "4", "start_pos": 47814290, "end_pos": 47813592, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095548.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095548.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", 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"MTRSRKQAALERGAGKMNSEAGSAAEGARAAAAGAAGNGTAPGVWGLEGDSEKVVYSRSQVSYAGTKALGDALKLFMPKSTEFMSSDSELWNFLCSLKHEFSPVILRSKDVYGYASCRAVVPDPPPPSAERPRHRPGKRRLPPAKRRAAVTGGSAKRPRRRRRRRRRAQGWRHRAAPAAGGPQGEERLQAAAGAPSEEEAEDSERGSPAEEAAWEQPFGGKSLEEIWKAATPRLITFPTIRVRGGVWNWRSLEAARRRAQRILGVDLSPVVRVRRLPVAPS", "length": 281 }, "evidence": [ { "id": "A0AAA9TH50", "url": "https://omabrowser.org/oma/group/A0AAA9TH50/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4FG98-1", "protein_name": "Coiled-coil domain containing 71 like", "gene_name": "CCDC71L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRSVKRRRRRPPAAPAAAARGGGFRAGAGPELEAREEKVVYSRSQLSLADSTKALGDAFKLFMPRSTEFMSSDAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPDPPGPPAARGRTRRPAPSAAARRRRRGARAPAARRRKPPPPPPLSPLPAPEESCPAKPAAPGPCFGGRTLEEIWRAATPTLTTFPTIRVGGDVWGERSLAAARRRASQVLRVNLEPVVRLRRFPVPRA", "length": 237 }, "evidence": [ { "id": "A0AAA9TH50", "url": "https://omabrowser.org/oma/group/A0AAA9TH50/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E9Q4T4-1", "protein_name": "Coiled-coil domain containing 71 like", "gene_name": "Ccdc71l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRRGVKRRRRRPRAAWGGGYGAEGGAGLEALEEKVVYSRSQLSLAGSTEALGDAFKLFMPSSTEFMSSEAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPDPPAPDSRPARRPRPRATPRRRRRGARAAADTRRPRPAAAAAEPGPPASSFGGRTLEEIWRAATPTLTSFPTIRVGDDVWGERSLAVARRRASQVLRVDLDPVVRLRRFPVHRL", "length": 218 }, "evidence": [ { "id": "A0AAA9TH50", "url": "https://omabrowser.org/oma/group/A0AAA9TH50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M119-1", "protein_name": "Coiled-coil domain containing 71-like", "gene_name": "Ccdc71l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRGVKRRRRRPRAAWGGGYGAEGGAGLEALEEKVVYSRSQLSLAGSTEALGDAFKLFMPSSTEFMSSEAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPDPPAPASRPARRPRPRATPRRRRRGAPAAAGTSRPRPAAAEPGPPASCFGGRTLEEIWRAATPTLTSFPTIRVGDDVWGERSLAVARRRARQVLRVDLDPVVRLRRFPVPRV", "length": 216 }, "evidence": [ { "id": "A0AAA9TH50", "url": "https://omabrowser.org/oma/group/A0AAA9TH50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N9Z2-1", "protein_name": "Coiled-coil domain-containing protein 71L", "gene_name": "CCDC71L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRSMKRRRRRRPVAPATAARGGDFRAEDGAGLEAREEKVVYSRSQLSLADSTKALGDAFKLFMPRSTEFMSSDAELWSFLCSLKHQFSPHILRSKDVYGYSSCRALVPDPPGPPTARGQARRPVPRAAARRRRRGARAAAARRRKPRPPPPPPPPPEESCPAKPVAPGPCFGGRTLEEIWRAATPTLTTFPTIRVGSDVWGERSLAAARRRARQVLRVNLEPMVRLRRFPVPRA", "length": 235 }, "evidence": [ { "id": "A0AAA9TH50", "url": "https://omabrowser.org/oma/group/A0AAA9TH50/", "database": "OMA" } ], "glygen_name": "Human", "common_name": 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Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways. Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor. Both inhibits and activates the TLR2-dependent signaling pathway. Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08477", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08477", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842221", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842221", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T729", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T729", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T729-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T729-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7Y7", "url": "https://www.uniprot.org/uniprotkb/F1N7Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7Y7-1", "url": "https://www.uniprot.org/uniprotkb/F1N7Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNAGEKHRNQ", "length": 1052, "header": "tr|A0AAA9THU9-1|A0AAA9THU9_BOVIN Isoform 1 of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVM6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0A3Q1MVM6-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGLLQAGHRSGCLDPTANRRNPHTCDAYILEEETHHQPECQGSC", "length": 1042, "header": "tr|A0A3Q1MVM6-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=2 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24879059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059138.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059138.2" } ] } }, { "isoform_ac": "A0AAA9RX21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9RX21-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKSNKTGH", "length": 1048, "header": "tr|A0AAA9RX21-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24876385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115426.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115426.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078035.1" } ] } }, { "isoform_ac": "A0AAA9SDL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9SDL3-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPEEEMWTQTHGGTTV", "length": 1013, "header": "tr|A0AAA9SDL3-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24906957, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109374.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109374.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084229.1" } ] } }, { "isoform_ac": "A0AAA9SDY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9SDY9-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGLLKCLCCA", "length": 1008, "header": "tr|A0AAA9SDY9-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24960667, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108328.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108328.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084350.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084350.1" } ] } }, { "isoform_ac": "A0AAA9T729-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9T729-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKSETAESWVRLHSLGVWHWEEEP", "length": 1064, "header": "tr|A0AAA9T729-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24874204, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122691.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122691.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093707.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093707.1" } ] } }, { "isoform_ac": "A0AAA9TA68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9TA68-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGKKQLMRVQ", "length": 1008, "header": "tr|A0AAA9TA68-1|A0AAA9THU9_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24884445, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123384.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123384.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094916.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094916.1" } ] } }, { "isoform_ac": "A0AAA9TH93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9TH93-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGL", "length": 1001, "header": "tr|A0AAA9TH93-1|A0AAA9TH93_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24882393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097610.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097610.1" } ] } }, { "isoform_ac": "A0AAA9THU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#A0AAA9THU9-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNAGEKHRNQ", "length": 1052, "header": "tr|A0AAA9THU9-1|A0AAA9THU9_BOVIN Isoform 1 of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=1 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24865470, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123519.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123519.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095779.1" } ] } }, { "isoform_ac": "F1N7Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9/entry#F1N7Y7-1", "sequence": { "sequence": "MAGTDSGNLKTVRLWRDAALRARKLRSNLRQLTLSSAGGCPGTDQLDSPDAPQLLLPANIGDIEVLNLGNNGLEEVPDGLGSALGSLRVLVLRRNRFAQLPQAVAELGHHLTELDVSHNRLSVLGAEAVGALRELRKLNLSHNQLPALPAQLGALVHLEELDVSFNRLAHLPDSFAGLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLRALPAQFSRLQRLKMLNLSSNLLEEFPAALLPLAGLEELYLSRNQLTSVPCLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGQKAAGKTLLRHCLTEDRVEGKLGGGGQEKTYPPSPPPGSKGIEVTSWTADASRGLRFIVYDLAGDERYEVIQPFFLSPGALYVLVVNLATYEPLRFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGEQELEEKCLDIHRQIALQEKHDAEGLSRLAQVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLSRLIDILNVFFQRDPSLLLHKLLLGTSGEAEAEGRAESSPLMAPPAPSQDALRATQLHHYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKAKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINNHVVHRSDGKLQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKYLHTFLDN", "length": 1050, "header": "tr|F1N7Y7-1|F1N7Y7_BOVIN Computationally mapped isoform of Multifunctional ROCO family signaling regulator 1 OS=Bos taurus OX=9913 GN=MFHAS1 PE=4 SV=3 CANONICAL=A0AAA9THU9-1" }, "locus": { "chromosome": "27", "start_pos": 24975050, "end_pos": 24871849, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021162.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021162.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021162.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021162.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1035, "start_aa": "Thr", "end_pos": 1035, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1035", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:782395", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782395", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZRZ8-1", "protein_name": "Multifunctional ROCO family signaling regulator 1", "gene_name": "Mfhas1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDSLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPSGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPTPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "length": 1048 }, "evidence": [ { "id": "A0AAA9THU9", "url": "https://omabrowser.org/oma/group/A0AAA9THU9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XHV2-1", "protein_name": "Multifunctional ROCO family signaling regulator 1", "gene_name": "MFHAS1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAQTEPPKAARLWRDAALRARKLRGGPGEPEPEPDEGPPGGPPPPPPAARRPPLGELEALNLSGRGLEELPEEVGAALSGLRVLSLRRNRLCRLPAAALRHLGRLAELDLSHNRLRGLGDGRALAGLRGLRKLSLSHNELGAESPGLPPRLAELARLEELDLSFNRLRRLPEGLGCLRHLRALDIDHNLLPCFPAPLLELAALEELDCSGNRHLGALPEGIAALRRLKILWLSGTGLAALPEGLCQLGALESLMLDGNQLRTLPAGFSGLQRLKMLNLSSNLLGEFPAAILALPGLEELYLSRNQLSVLPPRLCQLRQLRTLWLDNNRIRYLPDSIVLLHSLEELVLQGNQIAILPEGFGQLSRVTLWKIKDNPLIQPPYEVCMKGIPYIAAYQQELAHSQPALKPRLKLVLMGLKDAGKTLLRRCLMEENGQKEDAGSLEAGSVQPRGCPGQQQDSGRAAGCCPVPEDASEQRDICSHVPSHQGKGERPCPAPSLPPDASQVSSGLRLSGSKGIEVMDWTADAERGLTFIVYELAGDPTYDVIQSFFLSPGALYVLVVNLSAYVPQHFYPSVGYFLHWLGSKVPHAVVCMVGTHADLCAERELEEKCLDIHHQIAQQEKRDAEGLQSLVQQVDEALGQDFDLRCSSPHTAFYGVSDKNLRRKKAQFQYLLNHRPQILSPVLPFSCWDHCQVRRLRDKLLSVAEHRDIFPNLHRVLPKSWQVLEELHFQPQAQQLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEEHLTLREYVFHNLPRLIDILNVFCQRDATVLLQKLLSDTHIDELRATQLHHYVEGFLLHGLLPAHVIRLLLKPHIQSREDLQLILELLEKMGLCYCVNKPKSKPLNGAAAWYKFPCYVKNEVPHAEAWINGANLSGQSFVVEQLQIEYSFPFIFPPGLFARYSVQINSHVVQRSDGKYQIYAYRGKVPVVVSYRPARGALQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLYYTVHVLCSKCLKRGSPNPHSFPGELLSQPRPEGLTEIICPKNGSERVNVALVYPPTPTVISPCSNLAFHHDGDVLLICVGIWWRTCQSQINHQYWCQRFSTGEECG", "length": 1120 }, "evidence": [ { "id": "A0AAA9THU9", "url": "https://omabrowser.org/oma/group/A0AAA9THU9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3V1N1-1", "protein_name": "Malignant fibrous histiocytoma-amplified sequence 1 homolog", "gene_name": "Mfhas1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGQDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDPLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKNDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPSPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "length": 1048 }, "evidence": [ { "id": "A0AAA9THU9", "url": "https://omabrowser.org/oma/group/A0AAA9THU9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y4C4-1", "protein_name": "Malignant fibrous histiocytoma-amplified sequence 1", "gene_name": "MFHAS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELLRATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ", "length": 1052 }, "evidence": [ { "id": "A0AAA9THU9", "url": "https://omabrowser.org/oma/group/A0AAA9THU9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "negative regulation of toll-like receptor 2 signaling pathway", "id": "GO:0034136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "positive regulation of toll-like receptor 2 signaling pathway", "id": "GO:0034137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034137", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "regulation of toll-like receptor signaling pathway", "id": "GO:0034121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034121", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "negative regulation of protein localization to nucleus", "id": "GO:1900181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900181", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "erythrocyte differentiation", "id": "GO:0030218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030218", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "positive regulation of p38MAPK cascade", "id": "GO:1900745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900745", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "regulation of macrophage activation", "id": "GO:0043030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043030", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "negative regulation of toll-like receptor 4 signaling pathway", "id": "GO:0034144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034144", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THU9" } ], "pmid": "" }, { "name": "protein phosphatase 2A binding", "id": "GO:0051721", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ3" }, { "id": "PS50127", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50127" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBC core", "eco_id": "ECO_0000259", "start_pos": 73, "end_pos": 219, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.23", "ec_name": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "2.3.2.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.23" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 63 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TGQ0-1", "uniprot_ac": "A0AAA9TGQ0", "uniprot_id": "A0AAA9TGQ0_BOVIN", "mass": { "chemical_mass": 39594.0, "monoisotopic_mass": 39594.0 }, "refseq": {}, "gene_names": [ { "name": "CCDC90B", "type": "recommended", "evidence": [ { "id": "A0AAA9TGQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGQ0" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 90B", "type": "synonym", "evidence": [ { "id": "A0AAA9TGQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGQ0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGQ0", "url": 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isoform of Coiled-coil domain containing 90B OS=Bos taurus OX=9913 GN=CCDC90B PE=3 SV=2 CANONICAL=A0AAA9TGQ0-1" }, "locus": { "chromosome": "29", "start_pos": 12423021, "end_pos": 12385246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067664.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067664.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068378.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068378.2" } ] } }, { "isoform_ac": "A0AAA9TGQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGQ0/entry#A0AAA9TGQ0-1", "sequence": { "sequence": "MWGRWVRPLLRSEVSSPCGRFSPALRRGEKRHRVARCLCSLWGGGVGGWCQLGREEGEGASASLQPTPGPGDPAAEPRPERLRREARGPRTRARAPRKPVFPPGSFARAPPGVSLNPSLSREAGRPRPLADFFTTKTKEGYDMRRVDITPLEQRELTFDTHALVLDLEAHGFDKAQAETIVSALTTLSNVSLDTIYKEMVTQAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAENQKMKIELEQVKQQLINETSRIRADNKLDINLERSRVTDMFTDQEKKLMEATTEFTRNDTKTRGIISEIGNKIDTEIASLKTLMESNKLETIRYLAASVFTCLAIALGFYRLWK", "length": 351, "header": "tr|A0AAA9TGQ0-1|A0AAA9TGQ0_BOVIN Isoform 1 of Coiled-coil domain containing 90B OS=Bos taurus OX=9913 GN=CCDC90B PE=3 SV=1 CANONICAL=A0AAA9TGQ0-1" }, "locus": { "chromosome": "29", "start_pos": 12410561, "end_pos": 12385246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124245.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124245.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097362.1" } ] } }, { "isoform_ac": "A0ABI0P1R9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGQ0/entry#A0ABI0P1R9-1", "sequence": { "sequence": "MWGRWVRPLLRSEVSSPCGRFSPALRRDFFTTKTKEGYDMRRVDITPLEQRELTFDTHALVLDLEAHGFDKAQAETIVSALTTLSNVSLDTIYKEMVTQAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAENQKMKIELEQVKQQLINETSRIRADNKLDINLERSRVTDMDTKTRGIISEIGNKIDTEIASLKTLMESNKLETIRYLAASVFTCLAIALGFYRLWK", "length": 230, "header": "tr|A0ABI0P1R9-1|A0ABI0P1R9_BOVIN Computationally mapped isoform of Coiled-coil domain containing 90B OS=Bos taurus OX=9913 GN=CCDC90B PE=3 SV=1 CANONICAL=A0AAA9TGQ0-1" }, "locus": { "chromosome": "29", "start_pos": 12410561, "end_pos": 12385246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147503.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147503.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104664.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104664.1" } ] } }, { "isoform_ac": "F6QV15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGQ0/entry#F6QV15-1", "sequence": { "sequence": "MWGRWVRPLLRSEVSSPCGRFSPALRRDFFTTKTKEGYDMRRVDITPLEQRELTFDTHALVLDLEAHGFDKAQAETIVSALTTLSNVSLDTIYKEMVTQAQQEITVQQLMAHLDSIRKDMVILEKSEFANLRAENQNETSRIRADNKLDINLERSRVTDMFTDQEKKLMEATTEFTRNDTKTRGIISEIGNKIDTEIASLKTLMESNKLETIRYLAASVFTCLAIALGFYRLWK", "length": 234, "header": "tr|F6QV15-1|F6QV15_BOVIN Computationally mapped isoform of Coiled-coil domain containing 90B OS=Bos taurus OX=9913 GN=CCDC90B PE=3 SV=1 CANONICAL=A0AAA9TGQ0-1" }, "locus": { "chromosome": "29", "start_pos": 12410561, "end_pos": 12385246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009837.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009837.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009837.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009837.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 67, "start_aa": "Thr", "end_pos": 67, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr67", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], 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"annotation": "n_glycosylation_sequon" }, { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 67 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 254, "end_pos": 256 }, { "start_pos": 295, "end_pos": 297 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TH89-1", "uniprot_ac": "A0AAA9TH89", "uniprot_id": "A0AAA9TH89_BOVIN", "mass": { "chemical_mass": 124523.0, "monoisotopic_mass": 124523.0 }, "refseq": { "ac": "XP_024846248", "name": "voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846248" }, "gene_names": [ { "name": "CACNA2D1", "type": "recommended", "evidence": [ { "id": "A0AAA9TH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ] }, { "name": "CACNA2D1", "type": "synonym", "evidence": [ { "id": "XP_024846248", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846248" } ] } ], "protein_names": [ { "name": "Calcium voltage-gated channel auxiliary subunit alpha2delta 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#names_and_taxonomy" } ] }, { "name": "voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_024846248", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846248" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CACNA2D1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89", "locus": { "chromosome": "4", "start_pos": 38673177, "end_pos": 38153700, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020569", "url": "https://www.ensembl.org/id/ENSBTAG00000020569" } ] } } ], "crossref": [ { "id": "A0AAA9TH89", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TH89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020569", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020569", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01463", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01463", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18774", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18774", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282608", "url": "https://www.ncbi.nlm.nih.gov/gene/282608", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1N7F9", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1N7F9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282608", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282608", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NRTKTHQ", "url": "https://omabrowser.org/oma/group/NRTKTHQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NFD1", "url": "https://www.orthodb.org/?gene=A0A3Q1NFD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7F9", "url": "https://www.orthodb.org/?gene=F1N7F9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10166:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10166:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08399", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08399", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08473", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08473", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024846248", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846248", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFD1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST43", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7F9", "url": "https://www.uniprot.org/uniprotkb/F1N7F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7F9-1", "url": "https://www.uniprot.org/uniprotkb/F1N7F9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGLGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIIGIQCVLLWLLSGSRHHQL", "length": 1103, "header": "tr|A0AAA9TH89-1|A0AAA9TH89_BOVIN Isoform 1 of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NFD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0A3Q1NFD1-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARSKKGRMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIIGIQCVLLWLLSGSRHHQL", "length": 1091, "header": "tr|A0A3Q1NFD1-1|A0AAA9TH89_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38669217, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069478.1", "url": "https://www.ensembl.org/id/ENSBTAT00000069478.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070391.1" } ] } }, { "isoform_ac": "A0AAA9ST43-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0AAA9ST43-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALNSAQREQTEMPILQSFPERGALAYFGSCCLRIQPPISGFLSADRDLPHWDTDRC", "length": 1100, "header": "tr|A0AAA9ST43-1|A0AAA9TH89_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38659979, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114866.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114866.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089589.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089589.1" } ] } }, { "isoform_ac": "A0AAA9SXW5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0AAA9SXW5-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASDKIERSPSSVEIYNA", "length": 308, "header": "tr|A0AAA9SXW5-1|A0AAA9TH89_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38561479, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130360.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130360.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090205.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090205.1" } ] } }, { "isoform_ac": "A0AAA9SYQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0AAA9SYQ8-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVSNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGLGIPTINLRKRRPNVQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIIGIQCVLLWLLSGSRHHQL", "length": 1078, "header": "tr|A0AAA9SYQ8-1|A0AAA9TH89_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38669217, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089232.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089232.1" } ] } }, { "isoform_ac": "A0AAA9TGH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0AAA9TGH5-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNAL", "length": 1046, "header": "tr|A0AAA9TGH5-1|A0AAA9TGH5_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38653441, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111226.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111226.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096148.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096148.1" } ] } }, { "isoform_ac": "A0AAA9TH89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#A0AAA9TH89-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGLGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIIGIQCVLLWLLSGSRHHQL", "length": 1103, "header": "tr|A0AAA9TH89-1|A0AAA9TH89_BOVIN Isoform 1 of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=1 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38669217, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126373.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126373.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096430.1" } ] } }, { "isoform_ac": "F1N7F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89/entry#F1N7F9-1", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFTKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDLNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAYNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADVLHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALSKSMTKMARQSLVNL", "length": 1061, "header": "tr|F1N7F9-1|F1N7F9_BOVIN Computationally mapped isoform of Calcium voltage-gated channel auxiliary subunit alpha2delta 1 OS=Bos taurus OX=9913 GN=CACNA2D1 PE=3 SV=4 CANONICAL=A0AAA9TH89-1" }, "locus": { "chromosome": "4", "start_pos": 38662890, "end_pos": 38153721, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027409.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027409.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027409.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027409.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:282608", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282608", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O08532-1", "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-1", "gene_name": "Cacna2d1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGCLLALTLTLFQSGLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNVQNPKSQEPVTLDFLDAELENEIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSIADILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLL", "length": 1103 }, "evidence": [ { "id": "A0AAA9TH89", "url": "https://omabrowser.org/oma/group/A0AAA9TH89/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P54289-1", "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-1", "gene_name": "CACNA2D1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL", "length": 1103 }, "evidence": [ { "id": "A0AAA9TH89", "url": "https://omabrowser.org/oma/group/A0AAA9TH89/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P54290-1", "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-1", "gene_name": "Cacna2d1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGCLLALTLTLFQSWLIGPSSEEPFPSPVTIKSWVDKMQEDLVTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAMEAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESESGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFAADRLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFTFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYRYLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPRMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITDILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFKNDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRHYLW", "length": 1091 }, "evidence": [ { "id": "A0AAA9TH89", "url": "https://omabrowser.org/oma/group/A0AAA9TH89/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "id": "GO:0086057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086057", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "voltage-gated calcium channel activity", "id": "GO:0005245", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005245", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "neuronal dense core vesicle", "id": "GO:0098992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098992", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "presynaptic active zone membrane", "id": "GO:0048787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum", "id": "GO:0016529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "L-type voltage-gated calcium channel complex", "id": "GO:1990454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990454", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cellular response to amyloid-beta", "id": "GO:1904646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904646", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0035774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035774", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "regulation of heart rate by cardiac conduction", "id": "GO:0086091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "regulation of ventricular cardiac muscle cell membrane repolarization", "id": "GO:0060307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060307", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "id": "GO:1902514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902514", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "cardiac muscle cell action potential involved in contraction", "id": "GO:0086002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086002", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH89" } ], "pmid": "" }, { "name": "positive 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"A0A3Q1NK91", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NK91-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSH5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLX9", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTLRFNGRVVLVTGAGGGLGRAYALAFAERGASVVVNDLGGDFTGVGKGSLAADKVVEEIRRKGGKAVANYDSVEEGEKIVKTALDAFGRIDIVINNAGILRDRSFSRISDEDWDKIQRVHLRGSFLVTRAAWDHMKKQKFGRIIMTSSASGIYGNFGQANYCAAKLGLLGLSNCLAVEGKKNNIHCNTIAPTAGSRMTQSILPEDLVEALKPDYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERSLGALVRQRTQPMTPEAVKANWTKICDFDNATKPKSIQESIGSIVEALNKINSGGEVSANPTSRATSATTSEFARAIGHKFPPLYSSYAELDTIMYALGVGASIKEPKDMKFIYEGSSDFSCLPTFGVILAQKSIMNGGLAEIPGLSINLAKILHGEQYLELHKPIPRAGKLRCEAIVADILDKGSGLVILVDVYTYSGEELICYNQFSIFVVGSGGSGGKRTSDKAKAAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGGIVISNAYVDLVPASAISAKTPSEGAGLQSTLVFEEIGRRLQGIGEEVVKKVRAVFEWHITKGENTAAKWTIDLKTGSGKVYQGPAKGSADVTITLSDEDFMEVVLGKLDPQKGSPLCSVVLQVPVRPPLFGDMSPGLGNGEPERTLGQSLQGLTSLFLQSSLFIGTRNKGLRAYSQQNTYKARI", "length": 779, "header": "tr|A0AAA9TEQ9-1|A0AAA9TEQ9_BOVIN Isoform 1 of Peroxisomal multifunctional enzyme type 2 OS=Bos taurus OX=9913 GN=HSD17B4 PE=1 SV=1 CANONICAL=A0AAA9TEQ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NK91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9/entry#A0A3Q1NK91-1", "sequence": { "sequence": "MHFFSVNDLGGDFTGVGKGSLAADKVVEEIRRKGGKAVANYDSVEEGEKIVKTALDAFGRIDIVINNAGILRDRSFSRISDEDWDKIQRVHLRGSFLVTRAAWDHMKKQKFGRIIMTSSASGIYGNFGQANYCAAKLGLLGLSNCLAVEGKKNNIHCNTIAPTAGSRMTQSILPEDLVEALKPDYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERSLGALVRQRTQPMTPEAVKANWTKICDFDNATKPKSIQESIGSIVEALNKINSGGEVSANPTSRATSATTSEFARAIGHKFPPLYSSYAELDTIMYALGVGASIKEPKDMKFIYEGSSDFSCLPTFGVILAQKSIMNGGLAEIPGLSINLAKILHGEQYLELHKPIPRAGKLRCEAIVADILDKGSGLVILVDVYTYSGEELICYNQFSIFVVGSGGSGGKRTSDKAKAAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGGIVISNAYVDLVPASAISAKTPSEGAGLQSTLVFEEIGRRLQGIGEEVVKKVRAVFEWHITKGENTAAKWTIDLKTGSGKVYQGPAKGSADVTITLSDEDFMEVVLGKLDPQKAVFSGRLKARGNILLSQKLQMILKDYAKL", "length": 704, "header": "tr|A0A3Q1NK91-1|A0AAA9TEQ9_BOVIN Computationally mapped isoform of Peroxisomal multifunctional enzyme type 2 OS=Bos taurus OX=9913 GN=HSD17B4 PE=1 SV=2 CANONICAL=A0AAA9TEQ9-1" }, "locus": { "chromosome": "7", "start_pos": 34407244, "end_pos": 34325899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085683.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085683.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072705.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072705.2" } ] } }, { "isoform_ac": "A0AAA9RSH5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9/entry#A0AAA9RSH5-1", "sequence": { "sequence": "MASTLRFNGRVVLVTGAGGGLGRAYALAFAERGASVVDSVEEGEKIVKTALDAFGRIDIVINNAGILRDRSFSRISDEDWDKIQRVHLRGSFLVTRAAWDHMKKQKFGRIIMTSSASGIYGNFGQANYCAAKLGLLGLSNCLAVEGKKNNIHCNTIAPTAGSRMTQSILPEDLVEALKPDYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERSLGALVRQRTQPMTPEAVKANWTKICDFDNATKPKSIQESIGSIVEALNKINSGGEVSANPTSRATSATTSEFARAIGHKFPPLYSSYAELDTIMYALGVGASIKEPKDMKFIYEGSSDFSCLPTFGVILAQKSIMNGGLAEIPGLSINLAKILHGEQYLELHKPIPRAGKLRCEAIVADILDKGSGLVILVDVYTYSGEELICYNQFSIFVVGSGGSGGKRTSDKAKAAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGGIVISNAYVDLVPASAISAKTPSEGAGLQSTLVFEEIGRRLQGIGEEVVKKVRAVFEWHITKGENTAAKWTIDLKTGSGKVYQGPAKGSADVTITLSDEDFMEVVLGKLDPQKAVFSGRLKARGNILLSQKLQMILKDYAKL", "length": 700, "header": "tr|A0AAA9RSH5-1|A0AAA9TEQ9_BOVIN Computationally mapped isoform of Peroxisomal multifunctional enzyme type 2 OS=Bos taurus OX=9913 GN=HSD17B4 PE=1 SV=1 CANONICAL=A0AAA9TEQ9-1" }, "locus": { "chromosome": "7", "start_pos": 34425406, "end_pos": 34325899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094932.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094932.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075537.1" } ] } }, { "isoform_ac": "A0AAA9TEQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9/entry#A0AAA9TEQ9-1", "sequence": { "sequence": "MASTLRFNGRVVLVTGAGGGLGRAYALAFAERGASVVVNDLGGDFTGVGKGSLAADKVVEEIRRKGGKAVANYDSVEEGEKIVKTALDAFGRIDIVINNAGILRDRSFSRISDEDWDKIQRVHLRGSFLVTRAAWDHMKKQKFGRIIMTSSASGIYGNFGQANYCAAKLGLLGLSNCLAVEGKKNNIHCNTIAPTAGSRMTQSILPEDLVEALKPDYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERSLGALVRQRTQPMTPEAVKANWTKICDFDNATKPKSIQESIGSIVEALNKINSGGEVSANPTSRATSATTSEFARAIGHKFPPLYSSYAELDTIMYALGVGASIKEPKDMKFIYEGSSDFSCLPTFGVILAQKSIMNGGLAEIPGLSINLAKILHGEQYLELHKPIPRAGKLRCEAIVADILDKGSGLVILVDVYTYSGEELICYNQFSIFVVGSGGSGGKRTSDKAKAAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGGIVISNAYVDLVPASAISAKTPSEGAGLQSTLVFEEIGRRLQGIGEEVVKKVRAVFEWHITKGENTAAKWTIDLKTGSGKVYQGPAKGSADVTITLSDEDFMEVVLGKLDPQKGSPLCSVVLQVPVRPPLFGDMSPGLGNGEPERTLGQSLQGLTSLFLQSSLFIGTRNKGLRAYSQQNTYKARI", "length": 779, "header": "tr|A0AAA9TEQ9-1|A0AAA9TEQ9_BOVIN Isoform 1 of Peroxisomal multifunctional enzyme type 2 OS=Bos taurus OX=9913 GN=HSD17B4 PE=1 SV=1 CANONICAL=A0AAA9TEQ9-1" }, "locus": { "chromosome": "7", "start_pos": 34425406, "end_pos": 34292299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130775.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130775.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095304.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095304.1" } ] } }, { "isoform_ac": "A0AAF6DLX9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9/entry#A0AAF6DLX9-1", "sequence": { "sequence": "MASTLRFNGRVVLVTGAGGGLGRAYALAFAERGASVVVNDLGGDFTGVGKGSLAADKVVEEIRRKGGKAVANYDSVEEGEKIVKTALDAFGRIDIVINNAGILRDRSFSRISDEDWDKIQRVHLRGSFLVTRAAWDHMKKQKFGRIIMTSSASGIYGNFGQANYCAAKLGLLGLSNCLAVEGKKNNIHCNTIAPTAGSRMTQSILPEDLVEALKPDYVAPLVLWLCHESCEENGGLFEVFRTFLLSPKVGAGWIGKLRWERSLGALVRQRTQPMTPEAVKANWTKICDFDNATKPKSIQESIGSIVEALNKINSGGEVSANPTSRATSATTSEFARAIGHKFPPLYSSYAELDTIMYALGVGASIKEPKDMKFIYEGSSDFSCLPTFGVILAQKSIMNGGLAEIPGLSINLAKILHGEQYLELHKPIPRAGKLRCEAIVADILDKGSGLVILVDVYTYSGEELICYNQFSIFVVGSGGSGGKRTSDKAKAAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGGIVISNAYVDLVPASAISAKTPSEGAGLQSTLVFEEIGRRLQGIGEEVVKKVRAVFEWHITKGENTAAKWTIDLKTGSGKVYQGPAKGSADVTITLSDEDFMEVVLGKLDPQKAVFSGRLKARGNILLSQKLQMILKDYAKL", "length": 746, "header": "tr|A0AAF6DLX9-1|A0AAF6DLX9_BOVIN Computationally mapped isoform of Peroxisomal multifunctional enzyme type 2 OS=Bos taurus OX=9913 GN=HSD17B4 PE=1 SV=1 CANONICAL=A0AAA9TEQ9-1" }, "locus": { "chromosome": "7", "start_pos": 34425406, "end_pos": 34325899, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009173.7", "url": "https://www.ensembl.org/id/ENSBTAT00000009173.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009173.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009173.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 195, "start_aa": "Thr", "end_pos": 195, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr195", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-193368", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" }, { "id": "R-BTA-2046106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2046106", "resource": "Reactome", "description": "alpha-linolenic acid (ALA) metabolism" }, { "id": "R-BTA-389887", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "resource": "Reactome", "description": "Beta-oxidation of pristanoyl-CoA" }, { "id": "R-BTA-390247", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390247", "resource": "Reactome", "description": "Beta-oxidation of very long chain fatty acids" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "peroxisomal matrix", "id": "GO:0005782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005782", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "estrogen metabolic process", "id": "GO:0008210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008210", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "fatty acid beta-oxidation using acyl-CoA oxidase", "id": "GO:0033540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033540", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "androgen metabolic process", "id": "GO:0008209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008209", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "medium-chain fatty-acyl-CoA metabolic process", "id": "GO:0036112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036112", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "very long-chain fatty-acyl-CoA metabolic process", "id": "GO:0036111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036111", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "isomerase activity", "id": "GO:0016853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016853", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "(2E)-enoyl-CoA hydratase activity", "id": "GO:0080023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "id": "GO:0033989", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033989", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "id": "GO:0106386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106386", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "id": "GO:0016616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016616", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" }, { "name": "(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "id": "GO:0003857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003857", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18933", "name": "", "equation": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "18933", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18933" } ] }, { "id": "26526", "name": "", "equation": "a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "26526", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26526" } ] }, { "id": "32711", "name": "", "equation": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLJ3-1" ], "evidence": [ { "id": "32711", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32711" } ] }, { "id": "39159", "name": "", "equation": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7YY55-1", "Q0P5C7-1", "Q2KIP8-1", "F1MXJ1-1", "F1MXT1-1", "F1N0H2-1" ], "evidence": [ { "id": "39159", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39159" } ] }, { "id": "40187", "name": "", "equation": "(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "40187", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40187" } ] }, { "id": "40191", "name": "", "equation": "(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "40191", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40191" } ] }, { "id": "40243", "name": "", "equation": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "40243", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40243" } ] }, { "id": "40255", "name": "", "equation": "(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "40255", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40255" } ] }, { "id": "40263", "name": "", "equation": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "40263", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40263" } ] }, { "id": "45832", "name": "", "equation": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "45832", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45832" } ] }, { "id": "45992", "name": "", "equation": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "45992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45992" } ] }, { "id": "47088", "name": "", "equation": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "47088", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47088" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6DLJ3", "gene_name": "HSD17B8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "A0AAF6DLJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ3" } ] } ] }, { "uniprot_ac": "A7YY55", "gene_name": "HACD3", "activity": [ { "ec_number": "4.2.1.134", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O.", "evidence": [ { "id": "A7YY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY55" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "A7YY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YY55" } ] } ] }, { "uniprot_ac": "F1MXJ1", "gene_name": "HACD1", "activity": [ { "ec_number": "4.2.1.134", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O.", "evidence": [ { "id": "F1MXJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXJ1" } ] }, { "ec_number": "4.2.1.134", "activity": "", "evidence": [ { "id": "F1MXJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXJ1" } ] } ] }, { "uniprot_ac": "F1MXT1", "gene_name": "HACD2", "activity": [ { "ec_number": "4.2.1.134", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O.", "evidence": [ { "id": "F1MXT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXT1" } ] }, { "ec_number": 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"sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TF26-1", "uniprot_ac": "A0AAA9TF26", "uniprot_id": "A0AAA9TF26_BOVIN", "mass": { "chemical_mass": 80353.0, "monoisotopic_mass": 80353.0 }, "refseq": {}, "gene_names": [ { "name": "KY", "type": "recommended", "evidence": [ { "id": "A0AAA9TF26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ] } ], "protein_names": [ { "name": "Kyphoscoliosis peptidase", "type": "recommended", "evidence": [ { "id": "A0AAA9TF26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NM92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM92#function" }, { "database": "UniProtKB", "id": "ARBA00053717", "url": "https://www.uniprot.org/uniprotkb/ARBA00053717#function" }, { "database": "UniProtKB", "id": "A0AAA9S9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G5#function" }, { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KY", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26", "locus": { "chromosome": "1", "start_pos": 134743498, "end_pos": 134699294, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051206", "url": "https://www.ensembl.org/id/ENSBTAG00000051206" } ] } } ], "crossref": [ { "id": "A0AAA9TF26", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TF26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051206", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051206", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46333:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46333:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23265", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23265", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NM92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NM92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLAESAKRSAAAGRRGAPSPAPSRSVSRAGQRRARAICSAGRLASGRRAPAGAGGTMELKKDSNAVSIDMLLIVHSEKRRAAQGAHSDRPADPGAPPQRRGGLQGVGNGIRRWQKLEGNDLHGNLVEKQHAQQTQVITSYDNQGTQLTVEVHPRDAMPQLFKKFSLAKRLQVDKNGNTRPRQPGGKDTHAYPWDRSSLKSMALDLRQFEKLDTYASQVTVKSGLEELVSDLLQEAHSDLEIVRAIWIWICHHIEYDIEAAQEKDRQAFKPTVILQTQKTNCDGYAGLFERMCRIAGVQCVTVPGYSKGFGYQLGQSFSGEFDHAWNAVFLEGRWHLVDSTWGSGLVDSSTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFESNMYHKSEFYNKGMLSAQPQTSIIKTVNGKATVTIESCSPTLFMFMLNGKQEHGLLSLRKNGMKLDVYPPTAGTYKLQIFAKGNSEIYSSVLEYTLKCHCADNDVRLPAELHQPVGPSWFSEQMGITKPSHPEPVIYTSDGRCSVSFGVEEGISVLASLHGDDGPVTEETQRRYIFQLHREKQTELKVQLPHAGKFALKIFVKKRQEPGNYLFVFNYLICCTNTKVNWPVFPESFGNWGVDNELLEPLSGVLPANRNVPFKLKLHGVAKALVKGQDTWPLTLSPEGYWEGSCSTAGCQEVYVMVLENANHSFYSYILKYQVNAQ", "length": 719, "header": "tr|A0AAA9TF26-1|A0AAA9TF26_BOVIN Isoform 1 of Kyphoscoliosis peptidase OS=Bos taurus OX=9913 GN=KY PE=3 SV=1 CANONICAL=A0AAA9TF26-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NM92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26/entry#A0A3Q1NM92-1", "sequence": { "sequence": "MASLAESAKRSAAAGRRGAPSPAPSRSVSRAGQRRARAICSAGRLASGRRAPAGAGGTMELKKDSNAVSIDMLLIVHSEKRRAAQGAHSDRPADPGAPPQRRGGLQGVGNGIRRWQKLEGNDLHGTQLTVEVHPRDAMPQLFKKFSLAKRLQVDKNGNTRPRQPGGKDTHAYPWDRSSLKSMALDLRQFEKLDTYASQVTVKSGLEELVSDLLQEAHSDLEIVRAIWIWICHHIEYDIEAAQEKDRQAFKPTVILQTQKTNCDGYAGLFERMCRIAGVQCVTVPGYSKGFGYQLGQSFSGEFDHAWNAVFLEGRWHLVDSTWGSGLVDSSTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFESNMYHKSEFYNKGMLSAQPQTSIIKTVNGKATVTIESCSPTLFMFMLNGKQEHGLLSLRKNGMKLDVYPPTAGTYKLQIFAKGNSEIYSSVLEYTLKCHCADNDVRLPAELHQPVGPSWFSEQMGITKPSHPEPVIYTSDGRCSVSFGVEEGISVLASLHGDDGPVTEETQRRYIFQLHREKQTELKVQLPHAGKFALKIFVKKRQEPGNYLFVFNYLICCTNTKVNWPVFPESFGNWGVDNELLEPLSGVLPANRNVPFKLKLHGVAKALVKGQDTWPLTLSPEGYWEGSCSTAGCQEVYVMVLENANHSFYSYILKYQVNAQ", "length": 698, "header": "tr|A0A3Q1NM92-1|A0AAA9TF26_BOVIN Computationally mapped isoform of Kyphoscoliosis peptidase OS=Bos taurus OX=9913 GN=KY PE=3 SV=2 CANONICAL=A0AAA9TF26-1" }, "locus": { "chromosome": "1", "start_pos": 134742494, "end_pos": 134699391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075161.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075161.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073688.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073688.2" } ] } }, { "isoform_ac": "A0AAA9S9G5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26/entry#A0AAA9S9G5-1", "sequence": { "sequence": "MASLAESAKRSAAAGRRGAPSPAPSRSVSRAGQRRARAICSAGRLASGRRAPAGAGGTMELKKDSNAVSIDMLLIVHSEKRRAAQGAHSDRPADPGAPPQRRGGLQGVGNGIRRWQKLEGNDLHGNLVEKQHAQQTQVITSYDNQGTQLTVEVHPRDAMPQLFKKFSLAKRLQVDKNGNTRPRQPGGKDTHAYPWDRSSLKSMALDLRQFEKLDTYASQVTVKSGLEELVSDLLQEAHSDLEIVRAIWIWICHHIEYDIEAAQEKDRQAFKPTVILQTQKTNCDGYAGLFERMCRIAGVQCVTVPGYSKGFGYQLGQSFSGEFDHAWNAVFLEGRWHLVDSTWGSGLVDSSTSKFTFLEWKGHSHHR", "length": 367, "header": "tr|A0AAA9S9G5-1|A0AAA9TF26_BOVIN Computationally mapped isoform of Kyphoscoliosis peptidase OS=Bos taurus OX=9913 GN=KY PE=3 SV=1 CANONICAL=A0AAA9TF26-1" }, "locus": { "chromosome": "1", "start_pos": 134741629, "end_pos": 134699391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124358.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124358.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080050.1" } ] } }, { "isoform_ac": "A0AAA9TF26-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26/entry#A0AAA9TF26-1", "sequence": { "sequence": "MASLAESAKRSAAAGRRGAPSPAPSRSVSRAGQRRARAICSAGRLASGRRAPAGAGGTMELKKDSNAVSIDMLLIVHSEKRRAAQGAHSDRPADPGAPPQRRGGLQGVGNGIRRWQKLEGNDLHGNLVEKQHAQQTQVITSYDNQGTQLTVEVHPRDAMPQLFKKFSLAKRLQVDKNGNTRPRQPGGKDTHAYPWDRSSLKSMALDLRQFEKLDTYASQVTVKSGLEELVSDLLQEAHSDLEIVRAIWIWICHHIEYDIEAAQEKDRQAFKPTVILQTQKTNCDGYAGLFERMCRIAGVQCVTVPGYSKGFGYQLGQSFSGEFDHAWNAVFLEGRWHLVDSTWGSGLVDSSTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFESNMYHKSEFYNKGMLSAQPQTSIIKTVNGKATVTIESCSPTLFMFMLNGKQEHGLLSLRKNGMKLDVYPPTAGTYKLQIFAKGNSEIYSSVLEYTLKCHCADNDVRLPAELHQPVGPSWFSEQMGITKPSHPEPVIYTSDGRCSVSFGVEEGISVLASLHGDDGPVTEETQRRYIFQLHREKQTELKVQLPHAGKFALKIFVKKRQEPGNYLFVFNYLICCTNTKVNWPVFPESFGNWGVDNELLEPLSGVLPANRNVPFKLKLHGVAKALVKGQDTWPLTLSPEGYWEGSCSTAGCQEVYVMVLENANHSFYSYILKYQVNAQ", "length": 719, "header": "tr|A0AAA9TF26-1|A0AAA9TF26_BOVIN Isoform 1 of Kyphoscoliosis peptidase OS=Bos taurus OX=9913 GN=KY PE=3 SV=1 CANONICAL=A0AAA9TF26-1" }, "locus": { "chromosome": "1", "start_pos": 134742494, "end_pos": 134699391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120379.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120379.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097196.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097196.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF26", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TF26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF26" }, { "id": "SM00460", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00460" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Transglutaminase-like", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 343, "start_aa": "Ile", "end_aa": "Trp", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 704, "end_pos": 706 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9THR9-1", "uniprot_ac": "A0AAA9THR9", "uniprot_id": "A0AAA9THR9_BOVIN", "mass": { "chemical_mass": 106451.0, "monoisotopic_mass": 106451.0 }, "refseq": { "ac": "XP_010802358", "name": "PHD finger protein 14 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802358" }, "gene_names": [ { "name": "PHF14", "type": "recommended", "evidence": [ { "id": "A0AAA9THR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ] }, { "name": "PHF14", "type": "synonym", "evidence": [ { "id": "XP_010802358", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802358" } ] } ], "protein_names": [ { "name": "PHD finger protein 14", "type": "recommended", "evidence": [ { "id": "A0AAA9THR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#names_and_taxonomy" } ] }, { "name": "PHD finger protein 14 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010802358", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802358" } ] } ], "function": [ { "annotation": "Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation. Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9#function" }, { "database": "UniProtKB", "id": "ARBA00058058", "url": "https://www.uniprot.org/uniprotkb/ARBA00058058#function" }, { "database": "UniProtKB", "id": "A0AAA9RX51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX51#function" }, { "database": "UniProtKB", "id": "A0AAA9RRP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRP6#function" }, { "database": "UniProtKB", "id": "A0AAA9RZ04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ04#function" }, { "database": "UniProtKB", "id": "A0AAA9S1K6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1K6#function" }, { "database": "UniProtKB", "id": "A0AAA9SW10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW10#function" }, { "database": "UniProtKB", "id": "A0AAA9TIH7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIH7#function" }, { "database": "UniProtKB", "id": "A0AAA9TPL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL9#function" }, { "database": "UniProtKB", "id": "A0AAA9TW32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW32#function" }, { "database": "UniProtKB", "id": "A0AAA9TPA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9", "locus": { "chromosome": "4", "start_pos": 19264897, "end_pos": 19065677, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066096", "url": "https://www.ensembl.org/id/ENSBTAG00000066096" } ] } } ], "crossref": [ { "id": "A0AAA9THR9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9THR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15561", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15561", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15562", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15562", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15563", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15563", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15674", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15674", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537811", "url": "https://www.ncbi.nlm.nih.gov/gene/537811", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537811", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537811", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010802358", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802358", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RRP6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RX51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RX51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ04-1", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPA2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDENEAERKNISQELSVEQKNSKK", "length": 944, "header": "tr|A0AAA9THR9-1|A0AAA9THR9_BOVIN Isoform 1 of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9RRP6-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKACYIFTSI", "length": 928, "header": "tr|A0AAA9RRP6-1|A0AAA9THR9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19242683, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125747.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125747.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074865.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074865.1" } ] } }, { "isoform_ac": "A0AAA9RX51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9RX51-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKAYLKTKEQPSQGPCYEL", "length": 937, "header": "tr|A0AAA9RX51-1|A0AAA9THR9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19263987, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129349.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129349.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077071.1" } ] } }, { "isoform_ac": "A0AAA9RZ04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9RZ04-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRLEKLMATPPVFLPGKFHGQRSLAGYSPWGRKESDTTGQLSL", "length": 922, "header": "tr|A0AAA9RZ04-1|A0AAA9THR9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19168717, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102517.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102517.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076534.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076534.1" } ] } }, { "isoform_ac": "A0AAA9S1K6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9S1K6-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRFL", "length": 883, "header": "tr|A0AAA9S1K6-1|A0AAA9THR9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19163045, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107929.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107929.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077187.1" } ] } }, { "isoform_ac": "A0AAA9SW10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9SW10-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVSYMQSTS", "length": 887, "header": "tr|A0AAA9SW10-1|A0AAA9THR9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19166305, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094737.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094737.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088405.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088405.1" } ] } }, { "isoform_ac": "A0AAA9THR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9THR9-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKEDENEAERKNISQELSVEQKNSKK", "length": 944, "header": "tr|A0AAA9THR9-1|A0AAA9THR9_BOVIN Isoform 1 of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19264611, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118457.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118457.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097797.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097797.1" } ] } }, { "isoform_ac": "A0AAA9TIH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9TIH7-1", "sequence": { "sequence": "MIVQMTVILKLEMLQDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS", "length": 603, "header": "tr|A0AAA9TIH7-1|A0AAA9TIH7_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19196864, "end_pos": 19066643, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105708.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105708.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096931.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096931.1" } ] } }, { "isoform_ac": "A0AAA9TPA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9TPA2-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRYPS", "length": 884, "header": "tr|A0AAA9TPA2-1|A0AAA9TPA2_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19196864, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118658.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118658.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098186.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098186.1" } ] } }, { "isoform_ac": "A0AAA9TPL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9TPL9-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKDPAMNYEATTQNRNCRR", "length": 937, "header": "tr|A0AAA9TPL9-1|A0AAA9TPL9_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19264022, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104686.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104686.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098961.1" } ] } }, { "isoform_ac": "A0AAA9TW32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9/entry#A0AAA9TW32-1", "sequence": { "sequence": "MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDPSKDSGEGSCSDSEENILEEELNEDVKVKEEQLKNSAEEEVLSSEKQLIKVEKKEEEENGERPRKKKEKEKEREKEKEKEREKEKEKATVSDNVAAAASTTPATSPPAAHTCPSGPAATAAEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEEHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHILICCVCLGDNSEDADEIIQCDNCGITVHEGCYGVDGESDSIMSSASENSTEPWFCDACKCGVSPSCELCPNQDGIFKETDAGRWVHIVCALYVPGVAFGDIDKLRPVTLTEMNYSKYGAKECSFCEDPRFARTGVCISCDAGMCRAYFHVTCAQREGLLSEAAAEEDIADPFFAYCKQHADRLDRKWKRKNYLALQSYCKMSLQEREKQLSPEAQARINARLQQYRAKAELARSTRPQAWVPREKLPRPLTSSASAIRKLMRKAELMGISTDIFPVDNSDTSSSVDGRRKHKQPALTADFVNYYFERNMRMIQIQENMAEQKNIKDKLENEQEKLHVEYNKLCESLEELQNMNGKLRSEGQGIWALLGRITGQKLNIPAILRAPKERKPSKKEGGTQKASTLPAVLYSCGICKKNHDQHLLLLCDTCKLHYHLGCLDPPLTRMPRKTKNSYWQCSECDQAGSSDMEAEMAMETLPDGTKRSRRQIKEPVKFVPQDMPPEPKKIPIRNTRTRGRKRSFIPEEEKHEERVPRERRQRQSVLQKKPKAEDLRTECATCKGTGDNENLVRCDECRLCYHFGCLDPPLKKSPKQTGYGWICQECDSSSSKAYLKTKEQPSQGR", "length": 933, "header": "tr|A0AAA9TW32-1|A0AAA9TW32_BOVIN Computationally mapped isoform of PHD finger protein 14 OS=Bos taurus OX=9913 GN=PHF14 PE=4 SV=1 CANONICAL=A0AAA9THR9-1" }, "locus": { "chromosome": "4", "start_pos": 19264544, "end_pos": 19066074, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131014.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131014.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100818.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537811", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537811", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "germinal center B cell differentiation", "id": "GO:0002314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002314", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9THR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THR9" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" }, { "id": "PS51805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 315, "end_pos": 376, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 284, "end_pos": 286 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 428, "end_pos": 430 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 930, "end_pos": 932 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEV4-1", "uniprot_ac": "A0AAA9TEV4", "uniprot_id": "A0AAA9TEV4_BOVIN", "mass": { "chemical_mass": 54714.0, "monoisotopic_mass": 54714.0 }, "refseq": {}, "gene_names": [ { "name": "UPF3A", "type": "recommended", "evidence": [ { "id": "A0AAA9TEV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ] } ], "protein_names": [ { "name": "UPF3A regulator of nonsense mediated mRNA decay", "type": "synonym", "evidence": [ { "id": "A0AAA9TEV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UPF3A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4", "locus": { "chromosome": "12", "start_pos": 87083035, "end_pos": 87064203, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020858", "url": "https://www.ensembl.org/id/ENSBTAG00000020858" } ] } } ], "crossref": [ { "id": "A0AAA9TEV4", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020858", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020858", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR005120", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005120", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13112:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13112:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RSS7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSS7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGC9", "url": "https://www.uniprot.org/uniprotkb/E1BGC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BGC9-1", "url": "https://www.uniprot.org/uniprotkb/E1BGC9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSEDGAGGPGVAVATRGPSGREKPSSAESQFRRESPRREAEAPLASSSSCGSGAGKPREEKRTVLSKVVIRRLPPSLTKEQLEQQLHPLPAHDYFEFFTADVSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFIDSKGEYPAVVEFAPFQKIAKKKLKKKDAKTGSIEDDPEYKKFLETYCVEEEKTSVSPETLLGDIEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEEKCRRKAAEKQKKTAEKEVRMKLLKKPEKGEEPSTEKPKERAEETDPGDGKWEPCPSAVVLKPKPPEGSLEELRERSQNDSDKEQRDKERRSREKELEAQQCHLDDSRKHRAHHELEKCSGRNGEELARGKGSAADGGRRGSQDRGCPVEAAERPGRENSEDRLAPRKERTGNKDRPGLQLYQPRARIRACDCDGNGRRGEAEDSTVALAEKSEEAVW", "length": 476, "header": "tr|A0AAA9TEV4-1|A0AAA9TEV4_BOVIN Isoform 1 of UPF3A regulator of nonsense mediated mRNA decay OS=Bos taurus OX=9913 GN=UPF3A PE=3 SV=1 CANONICAL=A0AAA9TEV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RSS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4/entry#A0AAA9RSS7-1", "sequence": { "sequence": "MRSEDGAGGPGVAVATRGPSGREKPSSAESQFRRESPRREAEAPLASSSSCGSGAGKPREEKRTVLSKVVIRRLPPSLTKEQLEQQLHPLPAHDYFEFFTADVSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFIDSKDPEYKKFLETYCVEEEKTSVSPETLLGDIEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEEKCRRKAAEKQKKTAEKEVRMKLLKKPEKGEEPSTEKPKERAEETDPGDGKWEPCPSAVVLKPKPPEGSLEELRERSQNDSDKEQRDKERRSREKELEAQQCHLDDSRKHRAHHELEKCSGRNGEELARGKGSAADGGRRGSQDRGCPVEAAERPGRENSEDRLAPRKERTGNKDRPGLQLYQPRARIRACDCDGNGRRGEAEDSTVALAEKSEEAVW", "length": 444, "header": "tr|A0AAA9RSS7-1|A0AAA9TEV4_BOVIN Computationally mapped isoform of UPF3A regulator of nonsense mediated mRNA decay OS=Bos taurus OX=9913 GN=UPF3A PE=3 SV=1 CANONICAL=A0AAA9TEV4-1" }, "locus": { "chromosome": "12", "start_pos": 87082221, "end_pos": 87064233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113218.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113218.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074715.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074715.1" } ] } }, { "isoform_ac": "A0AAA9TEV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4/entry#A0AAA9TEV4-1", "sequence": { "sequence": "MRSEDGAGGPGVAVATRGPSGREKPSSAESQFRRESPRREAEAPLASSSSCGSGAGKPREEKRTVLSKVVIRRLPPSLTKEQLEQQLHPLPAHDYFEFFTADVSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFIDSKGEYPAVVEFAPFQKIAKKKLKKKDAKTGSIEDDPEYKKFLETYCVEEEKTSVSPETLLGDIEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEEKCRRKAAEKQKKTAEKEVRMKLLKKPEKGEEPSTEKPKERAEETDPGDGKWEPCPSAVVLKPKPPEGSLEELRERSQNDSDKEQRDKERRSREKELEAQQCHLDDSRKHRAHHELEKCSGRNGEELARGKGSAADGGRRGSQDRGCPVEAAERPGRENSEDRLAPRKERTGNKDRPGLQLYQPRARIRACDCDGNGRRGEAEDSTVALAEKSEEAVW", "length": 476, "header": "tr|A0AAA9TEV4-1|A0AAA9TEV4_BOVIN Isoform 1 of UPF3A regulator of nonsense mediated mRNA decay OS=Bos taurus OX=9913 GN=UPF3A PE=3 SV=1 CANONICAL=A0AAA9TEV4-1" }, "locus": { "chromosome": "12", "start_pos": 87082221, "end_pos": 87064233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095521.1" } ] } }, { "isoform_ac": "E1BGC9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4/entry#E1BGC9-1", "sequence": { "sequence": "MDCAAHGVIKSRTRLSDFHFDFSDSGGRKVVIRRLPPSLTKEQLEQQLHPLPAHDYFEFFTADVSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFIDSKGLEYPAVVEFAPFQKIAKKKLKKKDAKTGSIEDDPEYKKFLETYCVEEEKTSVSPETLLGDIEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEEKCRRKAAEKQKKTAEKEVRMKLLKKPEKGEEPSTEKPKERAEETDPGDGKWEPCPSAVVLKPKPPEGSLEELRERSQNDSDKEQRDKERRSREKELEAQQCHLDDSRKHRAHHELEKCSGRNGEELARGKGSAADGGRRGSQDRGCPVEAAERPGRENSEDRLAPRKERTGNKDRPGLQLYQPRARIRACDCDGRHPEEARDGRRGEAEDSTVALAEKSEEAVWGDMHVGDVGGGSPPQRSVDSRGRSFRKL", "length": 473, "header": "tr|E1BGC9-1|A0AAA9TEV4_BOVIN Computationally mapped isoform of UPF3A regulator of nonsense mediated mRNA decay OS=Bos taurus OX=9913 GN=UPF3A PE=3 SV=4 CANONICAL=A0AAA9TEV4-1" }, "locus": { "chromosome": "12", "start_pos": 87082305, "end_pos": 87064632, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027791.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027791.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027791.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027791.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "pmid": "" }, { "name": "exon-exon junction complex", "id": "GO:0035145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035145", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "pmid": "" }, { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEV4" }, { "id": "PF03467", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03467" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UPF3", "eco_id": "ECO_0000259", "start_pos": 67, "end_pos": 223, "start_aa": "Ser", "end_aa": "Lys", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 337, "end_pos": 339 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TE53-1", "uniprot_ac": "A0AAA9TE53", "uniprot_id": "A0AAA9TE53_BOVIN", "mass": { "chemical_mass": 48677.0, "monoisotopic_mass": 48677.0 }, "refseq": {}, "gene_names": [ { "name": "EFS", "type": "recommended", "evidence": [ { "id": "A0AAA9TE53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53" } ] } ], "protein_names": [ { "name": "Embryonal Fyn-associated substrate", "type": "synonym", "evidence": [ { "id": "A0AAA9TE53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EFS", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53", "locus": { "chromosome": "10", "start_pos": 21569078, "end_pos": 21559539, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038733", "url": "https://www.ensembl.org/id/ENSBTAG00000038733" } ] } } ], "crossref": [ { "id": "A0AAA9TE53", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TE53", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038733", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038733", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11571", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11571", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12003", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12003", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035747", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035747", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HRNEYEG", "url": "https://omabrowser.org/oma/group/HRNEYEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPX5", "url": "https://www.orthodb.org/?gene=A0A3Q1LPX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10654", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10654", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10654:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10654:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LPX5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1U3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1U3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1U3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIATSLYVVPPPARLCPTSRPPTGPCPPSPDPIYKVPRGGGTQLAAPGAALEVYDVPPTALRVPSNGPYDSPASFARPLAQVAPQSLGEDEAPYDVPLAPKSPSDLELDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLADGEGGGADEGIYDVPLLGPETPPSPEPLGASASSDLDTLALLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREVEDHPAGHHNEYEGIPVAEEYDYVHLKGMDKVQEARPPDKASPGDPEQLEREPPEQQEALSPGESLVLPTGDLQLLHFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLLTSLAP", "length": 468, "header": "tr|A0AAA9TE53-1|A0AAA9TE53_BOVIN Isoform 1 of Embryonal Fyn-associated substrate OS=Bos taurus OX=9913 GN=EFS PE=4 SV=1 CANONICAL=A0AAA9TE53-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPX5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53/entry#A0A3Q1LPX5-1", "sequence": { "sequence": "TDCPKSPSSKAAEPGLKTQAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPGLSQVPPTQPGSPHPAPEHGSEDQELYVVPPPARLCPTSRPPTGPCPPSPDPIYKVPRGGGTQLAAPGAALEVYDVPPTALRVPSNGPYDSPASFARPLAQVAPQSLGEDEAPYDVPLAPKSPSDLELDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLADGEGGGADEGIYDVPLLGPETPPSPEPLGASASSDLDTLALLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREVEDHPAGHHNEYEGIPVAEEYDYVHLKGMDKVQEARPPDKASPGDPEQLEREPPEQQEALSPGESLVLPTGDLQLLHFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLLTSLAP", "length": 574, "header": "tr|A0A3Q1LPX5-1|A0A3Q1LPX5_BOVIN Computationally mapped isoform of Embryonal Fyn-associated substrate OS=Bos taurus OX=9913 GN=EFS PE=3 SV=1 CANONICAL=A0AAA9TE53-1" }, "locus": { "chromosome": "10", "start_pos": 21568535, "end_pos": 21561157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086176.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086176.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059070.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059070.1" } ] } }, { "isoform_ac": "A0AAA9RV42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53/entry#A0AAA9RV42-1", "sequence": { "sequence": "MAIATSLYVVPPPARLCPTSRPPTGPCPPSPDPIYKVPRGGGTQLAAPGAALEVYDVPPTALRVPSNGPYDSPASFARPLAQVAPQSLGEDETPPSPEPLGASASSDLDTLALLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREVEDHPAGHHNEYEGIPVAEEYDYVHLKGMDKVQEARPPDKASPGDPEQLEREPPEQQEALSPGESLVLPTGDLQLLHFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLLTSLAP", "length": 392, "header": "tr|A0AAA9RV42-1|A0AAA9TE53_BOVIN Computationally mapped isoform of Embryonal Fyn-associated substrate OS=Bos taurus OX=9913 GN=EFS PE=4 SV=1 CANONICAL=A0AAA9TE53-1" }, "locus": { "chromosome": "10", "start_pos": 21568535, "end_pos": 21559693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106368.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106368.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076105.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076105.1" } ] } }, { "isoform_ac": "A0AAA9TE53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53/entry#A0AAA9TE53-1", "sequence": { "sequence": "MAIATSLYVVPPPARLCPTSRPPTGPCPPSPDPIYKVPRGGGTQLAAPGAALEVYDVPPTALRVPSNGPYDSPASFARPLAQVAPQSLGEDEAPYDVPLAPKSPSDLELDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLADGEGGGADEGIYDVPLLGPETPPSPEPLGASASSDLDTLALLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREVEDHPAGHHNEYEGIPVAEEYDYVHLKGMDKVQEARPPDKASPGDPEQLEREPPEQQEALSPGESLVLPTGDLQLLHFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLLTSLAP", "length": 468, "header": "tr|A0AAA9TE53-1|A0AAA9TE53_BOVIN Isoform 1 of Embryonal Fyn-associated substrate OS=Bos taurus OX=9913 GN=EFS PE=4 SV=1 CANONICAL=A0AAA9TE53-1" }, "locus": { "chromosome": "10", "start_pos": 21568535, "end_pos": 21559693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124814.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124814.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094453.1" } ] } }, { "isoform_ac": "A0AAA9U1U3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53/entry#A0AAA9U1U3-1", "sequence": { "sequence": "TDCPKSPSSKAAEPGLKTQAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPGLSQVPPTQPGSPHPAPEHGSEDQEVYDVPPTALRVPSNGPYDSPASFARPLAQVAPQSLGEDEAPYDVPLAPKSPSDLELDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLADGEGGGADEGIYDVPLLGPETPPSPEPLGASASSDLDTLALLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREVEDHPAGHHNEYEGIPVAEEYDYVHLKGMDKVQEARPPDKASPGDPEQLEREPPEQQEALSPGESLVLPTGDLQLLHFYAGQCQGHYSTLQAAVAALMSSTQAKQPPHLFVPHGKRALVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTALGQALRATVLAIKGAALGYPSSPAAEEMAQCVADLAGQALQFTTLLTSLAP", "length": 527, "header": "tr|A0AAA9U1U3-1|A0AAA9U1U3_BOVIN Computationally mapped isoform of Embryonal Fyn-associated substrate OS=Bos taurus OX=9913 GN=EFS PE=3 SV=1 CANONICAL=A0AAA9TE53-1" }, "locus": { "chromosome": "10", "start_pos": 21568535, "end_pos": 21561157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104381.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104381.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103260.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103260.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7GR57-1", "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "Efs", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAIATSAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLTSASPTQPGSCPTPEHGSEEQEVYVVPPPARPCPASGPLARSCSSSPDSIYKVPRVNGTQLTAPRDVLEVYDVPPSILRAPSSCPYDSPASFSCPLAPAVPQPPGEDEAPYDVPLALKPSAELEPDLEWEGGREPGPPLYSAPSNLKRASALLNLYEAPEELLANGESRDSDEGIYDVPLLGPESPSPESPGASSSADLDTVAQLLTKSPPLQHRPRLPSTESLSRRPLPALPVSEAPTPSPAPSPAPGRKGSIQDRPLPPPPPCLPGYGGLKPEGDPECREVDDDSADPHNEYEGIPMAEEYDYVHLKGVDKAQSSRPLDKASAMDPELLERGLQEQQESLTPEEPLVLSTGDLQLLNFYAGQCQSHYSALQAAVAALMSSTQANQPPCLFVPHGKRVVVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTMLGQTLRATVLAVKGAALGYPSGTAVQEMARCVAELAGQALRFTTLLTGLLP", "length": 559 }, "evidence": [ { "id": "A0AAA9TE53", "url": "https://omabrowser.org/oma/group/A0AAA9TE53/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A5G2R068-1", "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "EFS", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAIATSVYVVPPPARPCPTLVSPPGPCPPSPDPIYKVPRGSGTQLAVPGDALEVYDVPPTALRIPSNGPYDSPASFSRPLARVAPELPGEDEAPYDVPLAPKPPSELELDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLEDGEGGVTDEGIYDVPLLGPETPPSPEPLGASASHDLDTLALLLARSPPAPHRPRLPSAESLSRRPLPALPVPEAPSPSPAPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGGEVEDHPGYHNEYEGIPMAEEYDYVHLKGMDKAQEARPPDKASPGDPELLERGQPEQQDPLSPEEPLVLPAGDLQLLHFYAGQCQSYYSALQAAVAALMSSTQANQPPRLFVPHGKRVVVAAHRLVFVGDTLGRLATSGPLRAQVGAAGSALDQALRATVLAVKGAALGYPSSPVAQEMSQCVAELAGRALQFTTLLTSLAP", "length": 467 }, "evidence": [ { "id": "A0AAA9TE53", "url": "https://omabrowser.org/oma/group/A0AAA9TE53/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7F497-1", "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "Efs", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIATSAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPASPAPKPSLCPAPPTQPGCSSCPTPERGCEEQEVYVIPPPARPCSASGLPARSCSPSSDSIYKVPRVNGIQLTAPRDVGEVYDVPPNILRAPSNCPYDSPASFSCPATPVVPQPPGEDEAPYDVPLALKSPAEMEPDLEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLANGESRDADEGIYDVPLLGPEPPSPEPPAASSSADPDTVAQLLTRSPPPQHRPRLPSTESLSRRPLPALPVSEAPAPSPAPSPAPGRKGSIQDRPLPPPPPCLPGYGGLKPEGDPECREVDSDSGGPHNEYEGIPMAEEYDYVHLKGVDKAQGSRPLDNAFPADPELLERGLVEQKEALSPEEPLVLSTGDLQLLHFYAGQCQSHYSALQTAVAALMSSTQANQPPCLFVPHGKRVVVAAHRLVFVGDTLGRLAASAPLRAQVGAAGTVLAQTLRATVLAVKGAALGYPSDTAVQEMARCVAELAGQALRFTTLLAGLLP", "length": 561 }, "evidence": [ { "id": "A0AAA9TE53", "url": "https://omabrowser.org/oma/group/A0AAA9TE53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43281-1", "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "EFS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSPVPSPAPGRKGSIQDRPLPPPPPRLPGYGGPKVEGDPEGREMEDDPAGHHNEYEGIPMAEEYDYVHLKGMDKAQGSRPPDQACTGDPELPERGMPAPQEALSPGEPLVVSTGDLQLLYFYAGQCQSHYSALQAAVAALMSSTQANQPPRLFVPHSKRVVVAAHRLVFVGDTLGRLAASAPLRAQVRAAGTALGQALRATVLAVKGAALGYPSSPAIQEMVQCVTELAGQALQFTTLLTSLAP", "length": 561 }, "evidence": [ { "id": "A0AAA9TE53", "url": "https://omabrowser.org/oma/group/A0AAA9TE53/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64355-1", "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "Efs", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIATSAQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLCPASPTQPGSSCPTPERGCEEQEVYVIPPPARPCSASGLPARSCSPSSDSIYKVPRGNGMQLTASRDVAEVYDVPPNILRAPSSCPYDSPASFSCPVAPVVPQPPREDEAPYDVPLALKPPAELERDPEWEGGREPGPPLYAAPSNLKRASALLNLYEAPEELLANGESRDADEGIYDVPLLGPEPPSPEPPVASSSTDLDTVAQLPTRSSPPQHRPRLPSTESLSRRPLPALPVSEAPAPSPAPSPAPGRKGSIQDRPLPPPPPCLPGYGGLKPEGDPECREVANDPAGPHNEYEGIPMAEEYDYVHLKGVDTAQGSRPLDKAFPVDPELLERGLAERKEALSPEEPLVLSTGDLQLLHFYAGQCQSHYSALQAAVAALVASTQANQPPCLFVPHGKRVVVAAHRLVFVGDTLGRLAASAALRAQVGAAGTMLAQTLRATVLAVKGAALGYPSDTAVQEMARCVAELAGQALRFTTLLDGLLP", "length": 560 }, "evidence": [ { "id": "A0AAA9TE53", "url": "https://omabrowser.org/oma/group/A0AAA9TE53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TE53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TE53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE53" }, { "id": "PF12026", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CAS family C-terminal", "eco_id": "ECO_0000259", "start_pos": 279, "end_pos": 463, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFJ3-1", "uniprot_ac": "A0AAA9TFJ3", "uniprot_id": "A0AAA9TFJ3_BOVIN", "mass": { "chemical_mass": 32675.0, "monoisotopic_mass": 32675.0 }, "refseq": {}, "gene_names": [ { "name": "NPM1", "type": "recommended", "evidence": [ { "id": "A0AAA9TFJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3" } ] } ], "protein_names": [ { "name": "Nucleophosmin", "type": "recommended", "evidence": [ { "id": "A0AAA9TFJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3", "locus": { "chromosome": "20", "start_pos": 3218378, "end_pos": 3205494, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015316", "url": "https://www.ensembl.org/id/ENSBTAG00000015316" } ] } } ], "crossref": [ { "id": "ENSBTAG00000015316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614028", "url": "https://www.ncbi.nlm.nih.gov/gene/614028", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004301", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004301", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036824", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036824", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MTV9", "url": "https://www.orthodb.org/?gene=F1MTV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22747", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22747", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22747:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22747:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16276", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16276", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-606279", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-606279", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804115", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8869496", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8869496", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RVD2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0E1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLZ7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0U6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0U6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7V8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P7V8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P7V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTV9", "url": "https://www.uniprot.org/uniprotkb/F1MTV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTV9-1", "url": "https://www.uniprot.org/uniprotkb/F1MTV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDSMDMDMSPLRPQNYLFGCELKADRDYHFKVDNDENEHQLSLRTVSLGAGAKDELHVVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEEEEEEEVKLLSISGKRSAPGSGSKVPQKKVKLAADEDEDDDDDDDDDDDEDDDDDDFDEEVEEKAPVKKSVRDTPAKNAQKSNQNGKDSKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL", "length": 294, "header": "tr|A0AAA9TFJ3-1|A0AAA9TFJ3_BOVIN Isoform 1 of Nucleophosmin OS=Bos taurus OX=9913 GN=NPM1 PE=3 SV=2 CANONICAL=A0AAA9TFJ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVD2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3/entry#A0AAA9RVD2-1", "sequence": { "sequence": "MEDSMDMDMSPLRPQNYLFGCELKADRDYHFKVDNDENEHQLSLRTVSLGAGAKDELHVVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEEEEEEEVKLLSISGKRSAPGSGSKVPQKKVKLAADEDEDDDDDDDDDDDEDDDDDDFDEEVEEKAPVKKSVRDTPAKNAQKSNQNGKDSKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKAH", "length": 259, "header": "tr|A0AAA9RVD2-1|A0AAA9TFJ3_BOVIN Computationally mapped isoform of Nucleophosmin OS=Bos taurus OX=9913 GN=NPM1 PE=3 SV=2 CANONICAL=A0AAA9TFJ3-1" }, "locus": { "chromosome": "20", "start_pos": 3214870, "end_pos": 3205593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102801.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102801.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077280.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077280.2" } ] } }, { "isoform_ac": "A0AAA9S0E1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3/entry#A0AAA9S0E1-1", "sequence": { "sequence": "MNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEEEEEEEVKLLSISGKRSAPGSGSKVPQKKVKLAADEDEDDDDDDDDDDDEDDDDDDFDEEVEEKAPVKKSVRDTPAKNAQKSNQNGKDSKPSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL", "length": 230, "header": "tr|A0AAA9S0E1-1|A0AAA9TFJ3_BOVIN Computationally mapped isoform of Nucleophosmin OS=Bos taurus OX=9913 GN=NPM1 PE=3 SV=2 CANONICAL=A0AAA9TFJ3-1" }, "locus": { "chromosome": "20", "start_pos": 3218058, "end_pos": 3208118, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087886.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087886.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079310.2", "url": "https://www.ensembl.org/id/ENSBTAP00000079310.2" } ] } }, { "isoform_ac": "A0AAA9TFJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFJ3/entry#A0AAA9TFJ3-1", "sequence": { "sequence": 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{ "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M618", "url": "https://www.orthodb.org/?gene=A0A3Q1M618", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGC8", "url": "https://www.orthodb.org/?gene=F1MGC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10606", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10606", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10606:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10606:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00300", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00300", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01591", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01591", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9634600", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9634600", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M618", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M618", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M618-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M618-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXR0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGC8", "url": "https://www.uniprot.org/uniprotkb/F1MGC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MGC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQISVGCAGLGHPGRGLYHLSPEPVGSWACASSILACRAGPLSPKRALGRAGHAWSDARHLCWGGAYSTWGGACGEWDRRQRGSGRGGAEGRGLEWPEVARLLGWQQRSRTHPSPRMASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 585, "header": "tr|A0AAA9TI21-1|A0AAA9TI21_BOVIN Isoform 1 of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=1 CANONICAL=A0AAA9TI21-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M618-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21/entry#A0A3Q1M618-1", "sequence": { "sequence": "MNRGMEGGSSPTEPGSGSSRRVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 458, "header": "tr|A0A3Q1M618-1|A0A3Q1M618_BOVIN Computationally mapped isoform of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=1 CANONICAL=A0AAA9TI21-1" }, "locus": { "chromosome": "22", "start_pos": 51361544, "end_pos": 51322032, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079202.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079202.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069165.1" } ] } }, { "isoform_ac": "A0AAA9RXR0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21/entry#A0AAA9RXR0-1", "sequence": { "sequence": "MGGNLPGLTAPGADLYFSSSGPAQGNASRYRSGLSSGSPSRDLSLPPWRHHQMVVTGQHYACLSLLAPWSSEGPGWCSFPLPRVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 520, "header": "tr|A0AAA9RXR0-1|A0AAA9TI21_BOVIN Computationally mapped isoform of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=1 CANONICAL=A0AAA9TI21-1" }, "locus": { "chromosome": "22", "start_pos": 51361544, "end_pos": 51327494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106274.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106274.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076007.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076007.1" } ] } }, { "isoform_ac": "A0AAA9TI21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21/entry#A0AAA9TI21-1", "sequence": { "sequence": "MQISVGCAGLGHPGRGLYHLSPEPVGSWACASSILACRAGPLSPKRALGRAGHAWSDARHLCWGGAYSTWGGACGEWDRRQRGSGRGGAEGRGLEWPEVARLLGWQQRSRTHPSPRMASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 585, "header": "tr|A0AAA9TI21-1|A0AAA9TI21_BOVIN Isoform 1 of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=1 CANONICAL=A0AAA9TI21-1" }, "locus": { "chromosome": "22", "start_pos": 51361544, "end_pos": 51325431, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123799.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123799.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096752.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096752.1" } ] } }, { "isoform_ac": "A0AAA9TQ28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21/entry#A0AAA9TQ28-1", "sequence": { "sequence": "MLYGPVFVSVGVQASRWGCGPAQGNASRYRSGLSSGSPSRDLSLPPWRHHQMVVTGQHYACLSLLAPWSSEGPGWCSFPLPRVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 519, "header": "tr|A0AAA9TQ28-1|A0AAA9TQ28_BOVIN Computationally mapped isoform of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=1 CANONICAL=A0AAA9TI21-1" }, "locus": { "chromosome": "22", "start_pos": 51361544, "end_pos": 51326384, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125010.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125010.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100486.1" } ] } }, { "isoform_ac": "F1MGC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21/entry#F1MGC8-1", "sequence": { "sequence": "MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYKSFEFFLPDNEEGLKIRKQCALTALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYINRDSDEAAEDFMRRIECYENSYETLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFIRDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDASYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ", "length": 434, "header": "tr|F1MGC8-1|F1MGC8_BOVIN Computationally mapped isoform of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 OS=Bos taurus OX=9913 GN=PFKFB4 PE=3 SV=3 CANONICAL=A0AAA9TI21-1" }, "locus": { "chromosome": "22", "start_pos": 51361544, "end_pos": 51325779, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008887.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008887.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008887.4", "url": "https://www.ensembl.org/id/ENSBTAP00000008887.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 364, "start_aa": "Thr", "end_pos": 364, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr364", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9634600", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9634600", "resource": "Reactome", "description": "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" }, { "name": "6-phosphofructo-2-kinase activity", "id": "GO:0003873", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003873", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" }, { "name": "fructose-2,6-bisphosphate 2-phosphatase activity", "id": "GO:0004331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004331", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fructose metabolic process", "id": "GO:0006000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006000", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" }, { "name": "fructose 2,6-bisphosphate metabolic process", "id": "GO:0006003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006003", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TI21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI21" }, { "id": "PF01591", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01591" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "6-phosphofructo-2-kinase", "eco_id": "ECO_0000259", "start_pos": 151, "end_pos": 365, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 364 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 248, "end_pos": 250 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFZ5-1", "uniprot_ac": "A0AAA9TFZ5", "uniprot_id": "A0AAA9TFZ5_BOVIN", "mass": { "chemical_mass": 62389.0, "monoisotopic_mass": 62389.0 }, "refseq": { "ac": "NP_001341507", "name": "syntaxin-binding protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341507" }, "gene_names": [ { "name": "STXBP4", "type": "recommended", "evidence": [ { "id": "A0AAA9TFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5" } ] }, { "name": "STXBP4", "type": "synonym", "evidence": [ { "id": "NP_001341507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341507" } ] } ], "protein_names": [ { "name": "Syntaxin-binding protein 4", "type": "recommended", "evidence": [ { "id": "A0AAA9TFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#names_and_taxonomy" } ] }, { "name": "Syntaxin 4-interacting protein", "type": "synonym", "evidence": [ { "id": "A0AAA9TFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#names_and_taxonomy" } ] }, { "name": "syntaxin-binding protein 4", "type": "synonym", "evidence": [ { "id": "NP_001341507", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341507" } ] } ], "function": [ { "annotation": "Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SCJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ1#function" }, { "database": "UniProtKB", "id": "ARBA00053815", "url": "https://www.uniprot.org/uniprotkb/ARBA00053815#function" }, { "database": "UniProtKB", "id": "A0AAA9TFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STXBP4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5", "locus": { "chromosome": "19", "start_pos": 5338417, "end_pos": 5090002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016078", "url": "https://www.ensembl.org/id/ENSBTAG00000016078" } ] } } ], "crossref": [ { "id": "A0AAA9TFZ5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016078", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016078", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06698", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06698", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537963", "url": "https://www.ncbi.nlm.nih.gov/gene/537963", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BAL5", "url": "https://www.orthodb.org/?gene=E1BAL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19964", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19964", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19964:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19964:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001341507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341507", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RY19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCJ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFX7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM27", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMW8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMW8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL5", "url": "https://www.uniprot.org/uniprotkb/E1BAL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BAL5-1", "url": "https://www.uniprot.org/uniprotkb/E1BAL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDCLPYGWEAAYTADGIKYFINHVTQTTSWVHPVMSALNLSCSEEDEEDGSREPPDQRNS", "length": 560, "header": "tr|A0AAA9TFZ5-1|A0AAA9TFZ5_BOVIN Isoform 1 of Syntaxin-binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=2 CANONICAL=A0AAA9TFZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RY19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9RY19-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDCLPYGWEAAYTADGIKYFIKGKKRSGRISRTCAGSPSTLRLM", "length": 505, "header": "tr|A0AAA9RY19-1|A0AAA9TFZ5_BOVIN Computationally mapped isoform of Syntaxin-binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5337413, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128267.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128267.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074708.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074708.1" } ] } }, { "isoform_ac": "A0AAA9SCJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9SCJ1-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDCLPYGWEAAYTADGIKYFINHVTQTTSWVHPVMSALNLSCSEEDEEDGSREPPDQRNS", "length": 521, "header": "tr|A0AAA9SCJ1-1|A0AAA9TFZ5_BOVIN Computationally mapped isoform of Syntaxin-binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5315866, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093947.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093947.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081592.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081592.1" } ] } }, { "isoform_ac": "A0AAA9SFX7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9SFX7-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDWLQKS", "length": 507, "header": "tr|A0AAA9SFX7-1|A0AAA9TFZ5_BOVIN Computationally mapped isoform of Syntaxin-binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5233642, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111671.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111671.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082780.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082780.1" } ] } }, { "isoform_ac": "A0AAA9TFZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9TFZ5-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDCLPYGWEAAYTADGIKYFINHVTQTTSWVHPVMSALNLSCSEEDEEDGSREPPDQRNS", "length": 560, "header": "tr|A0AAA9TFZ5-1|A0AAA9TFZ5_BOVIN Isoform 1 of Syntaxin-binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=2 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5315866, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097482.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097482.2" } ] } }, { "isoform_ac": "A0AAA9TM27-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9TM27-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDFSLSHQEASISLLILLHQKADRMKTTVTES", "length": 532, "header": "tr|A0AAA9TM27-1|A0AAA9TM27_BOVIN Computationally mapped isoform of Syntaxin binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5246147, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088795.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088795.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099440.1" } ] } }, { "isoform_ac": "A0AAA9TMW8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9TMW8-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDLLCSVAQSSLTP", "length": 514, "header": "tr|A0AAA9TMW8-1|A0AAA9TMW8_BOVIN Computationally mapped isoform of Syntaxin binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5270054, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096756.2", "url": "https://www.ensembl.org/id/ENSBTAT00000096756.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099705.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099705.1" } ] } }, { "isoform_ac": "A0AAA9TSC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ5/entry#A0AAA9TSC2-1", "sequence": { "sequence": "MNKNTSSVVSSSLLEKDPAFQMITVTKKTGLGLKILGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKGIITRAKLRSESSWEIAFIRQKSDSSHLENPSCSSLLEATGEYGPHASKFSLISSPETLIPKTSSTPRSTDAILPSLRRNQIKTGYKKTEQIPITSSDNSPTDMSNTDIAPAWTDNYGPQGKKISLNPSVRVKVEKLEMALNYLGIQPTKEQHQALRQQVQVDTKGTVSFGDFVHVARNLFCLQLDEANVGAHEISSILNSQISQEAGDSLETDEVEKLKHERNNALEEVKTLKEKLFESERQRKQLTEELQNVKQEAKAVVEETRALRSRLHLAEAAQRQAQGMEMDYEEVIRLLEAEITELKAQLADYSDQNKESVQELRKRITVLDCQLRKSEMARKTFEASTEKLLHFVEAIQDVFSDNSAPLSNLSERRALLASQTSLTPLGKNGHNIPATLALESKELVKSVRAILDMDCLPYGWEAAYTADGIKYFINLDRNAFSSCWPAVLHCALGNSSHVRVGVRRTQRGLPTDSSDLKRLSFFLFKFYFIYFTVLYWFCHMSK", "length": 590, "header": "tr|A0AAA9TSC2-1|A0AAA9TSC2_BOVIN Computationally mapped isoform of Syntaxin binding protein 4 OS=Bos taurus OX=9913 GN=STXBP4 PE=4 SV=1 CANONICAL=A0AAA9TFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 5294609, "end_pos": 5116556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113014.2", "url": 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"url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00792", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00792", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010803751", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010803751", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12709", "url": "https://www.rhea-db.org/rhea/12709", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "18373", "url": "https://www.rhea-db.org/rhea/18373", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D1", "url": "https://www.uniprot.org/uniprotkb/E1B8D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8D1-1", "url": "https://www.uniprot.org/uniprotkb/E1B8D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYYWKTDLNSSESHEKQQEHQEFPSLNQPLFSSLVSLGFDNVVEEISNKIPLCQREIEENAFFVPSALHWDSRTHSLDEIHQTSLNEFTSKSSELSCHQVRETPVIGFSRHSVLPNPQNINKGSSWGNPIGKYHGADDYGFNILPLSSTSLDKNNSQSQLENENHNYHIGFESSVLPIYPFLSTNLMPKEENKSRRNMNVVESSLMPFQGSSLPRTWESTHPKNTELTGCSIQLVEVAQGSNMSLASFCNKVKKIRETYHAADMDSNSGKIWSTTTAFPYKLFSNTKFNINIFTDNSTKGLHFIPCANYLVKDLIAEILHFCMNDQLFPRDHLLSICGHEEFLQNDHYLGSHRVFQKNKSVIQLHLQKKRDTPGTLSRKHEDDHSQFYLNQLLEFMHIWKVSRQCLSTVIQKYDSHLKYLLKTQQNVDNVIEEVKSICSVLGCVETKQITDAINELNLILQRKPKNLHQNSDTSAKGLIEKVTTELSTSICQLIDIHCSSFCADFQPLHAPLYSVSCVNLGLHSHLSFTVYAAHNIPETWVHSYKAFSFSCWLTYAGKKLCQVRNCRNIPVKKLFFFLVNWNETINFPLEIKSLPRESMLTIKLFGITYATNADLLAWTCFPLFPKHRSILGSALFSMTLQSEPPMEMIAPGVWDVSQPSPVTLQIDFPATEWEYMKLDSEENGSDLEEPPKECLKHIARLSQKQTPILLSEEKRRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWKFSHPLEALGLLTSSFPDQEIRNVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSVQIAHRLYWLLKDAQNEAYFKIWYQKLLAALQFCAGKALRDEFSKEQKLIKILGDIGEKVKTASDPQRQEVLKKELGRLEEFFWCTKTCHLPLNPALCVQGIDGDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMVIYRCLSTGKGQGLVQMVPDAVTLAKIHRCFGPIGPLKENTIKKWFSQHNPLKADYEKVLRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIVRRHSRLLLNLLEMMLHAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMTAISPAKLTSQTFSQESCMSGASRSIQRATVLGFSKKTSHLYLIQVTHSNNETSLTEKSFDQFAKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHKRFRDLNHYMEQILNGSYEVANSDCVLSFFLSEPVEQAVKESSAVDLGEKFADKKPKVQLVISYKDAKLTILVKHMKNIHLPDGSTPSAHVEFYLLPYPSEARRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTTFVGAINIQLCSVTLNEEKWYPLGNSII", "length": 1487, "header": "tr|A0AAA9THJ4-1|A0AAA9THJ4_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma OS=Bos taurus OX=9913 GN=PIK3C2G PE=3 SV=1 CANONICAL=A0AAA9THJ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4/entry#A0AAA9RZU8-1", "sequence": { "sequence": "MAYYWKTDLNSSESHEKQQEHQEFPSLNQPLFSSLVSLGFDNVVEEISNKIPLCQREIEENAFFVPSALHWDSRTHSLDEIHQTSLNEFTSKSSELSCHQVRETPVIGFSRHSVLPNPQNINKGSSWGNPIGKYHGADDYGFNILPLSSTSLDKNNSQSQLENENHNYHIGFESSVLPIYPFLSTNLMPKEENKSRRNMNVVESSLMPFQGSSLPRTWESTHPKNTELTGCSIQLVEVAQGSNMSLASFCNKVKKIRETYHAADMDSNSGKIWSTTTAFPYKLFSNTKFNINIFTDNSTKGLHFIPCANYLVKDLIAEILHFCMNDQLFPRDHLLSICGHEEFLQNDHYLGSHRVFQKNKSVIQLHLQKKRDTPGTLSRKHEDDHSQFYLNQLLEFMHIWKVSRQCLSTVIQKYDSHLKYLLKTQQNVDNVIEEVKSICSVLGCVETKQITDAINELNLILQRKPKNLHQNSDTSAKGLIEKVTTELSTSICQLIDIHCSSFCADFQPLHAPLYSVSCVNLGLHSHLSFTVYAAHNIPETWVHSYKAFSFSCWLTYAGKKLCQVRNCRNIPVKKLFFFLVNWNETINFPLEIKSLPRESMLTIKLFGITYATNADLLAWTCFPLFPKQSILGSALFSMTLQSEPPMEMIAPGVWDVSQPSPVTLQIDFPATEWEYMKLDSEENGSDLEEPPKECLKHIARLSQKQTPILLSEEKRRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWKFSHPLEALGLLTSSFPDQEIRNVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSVQIAHRLYWLLKDAQNEAYFKIWYQKLLAALQFCAGKALRDEFSKEQKLIKILGDIGEKVKTASDPQRQEVLKKELGRLEEFFWCTKTCHLPLNPALCVQGIDGDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMVIYRCLSTGKGQGLVQMVPDAVTLAKIHRCFGPIGPLKENTIKKWFSQHNPLKADYEKVLRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIVRRHSRLLLNLLEMMLHAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMTAISPAKLTSQTFSQESCMSGASRSIQRATVLGFSKKTSHLYLIQVTHSNNETSLTEKSFDQFAKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHKRFRDLNHYMEQILNGSYEVANSDCVLSFFLSEPVEQAVKESSAVDLGEKFADKKPKVQLVISYKDAKLTILVKHMKNIHLPDGSTPSAHVEFYLLPYPSEARRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTTFVGAINIQLCSVTLNEEKWYPLGNSII", "length": 1486, "header": "tr|A0AAA9RZU8-1|A0AAA9THJ4_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma OS=Bos taurus OX=9913 GN=PIK3C2G PE=3 SV=1 CANONICAL=A0AAA9THJ4-1" }, "locus": { "chromosome": "5", "start_pos": 91842738, "end_pos": 91399889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135986.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135986.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076886.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076886.1" } ] } }, { "isoform_ac": "A0AAA9THJ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4/entry#A0AAA9THJ4-1", "sequence": { "sequence": "MAYYWKTDLNSSESHEKQQEHQEFPSLNQPLFSSLVSLGFDNVVEEISNKIPLCQREIEENAFFVPSALHWDSRTHSLDEIHQTSLNEFTSKSSELSCHQVRETPVIGFSRHSVLPNPQNINKGSSWGNPIGKYHGADDYGFNILPLSSTSLDKNNSQSQLENENHNYHIGFESSVLPIYPFLSTNLMPKEENKSRRNMNVVESSLMPFQGSSLPRTWESTHPKNTELTGCSIQLVEVAQGSNMSLASFCNKVKKIRETYHAADMDSNSGKIWSTTTAFPYKLFSNTKFNINIFTDNSTKGLHFIPCANYLVKDLIAEILHFCMNDQLFPRDHLLSICGHEEFLQNDHYLGSHRVFQKNKSVIQLHLQKKRDTPGTLSRKHEDDHSQFYLNQLLEFMHIWKVSRQCLSTVIQKYDSHLKYLLKTQQNVDNVIEEVKSICSVLGCVETKQITDAINELNLILQRKPKNLHQNSDTSAKGLIEKVTTELSTSICQLIDIHCSSFCADFQPLHAPLYSVSCVNLGLHSHLSFTVYAAHNIPETWVHSYKAFSFSCWLTYAGKKLCQVRNCRNIPVKKLFFFLVNWNETINFPLEIKSLPRESMLTIKLFGITYATNADLLAWTCFPLFPKHRSILGSALFSMTLQSEPPMEMIAPGVWDVSQPSPVTLQIDFPATEWEYMKLDSEENGSDLEEPPKECLKHIARLSQKQTPILLSEEKRRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWKFSHPLEALGLLTSSFPDQEIRNVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSVQIAHRLYWLLKDAQNEAYFKIWYQKLLAALQFCAGKALRDEFSKEQKLIKILGDIGEKVKTASDPQRQEVLKKELGRLEEFFWCTKTCHLPLNPALCVQGIDGDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMVIYRCLSTGKGQGLVQMVPDAVTLAKIHRCFGPIGPLKENTIKKWFSQHNPLKADYEKVLRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIVRRHSRLLLNLLEMMLHAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMTAISPAKLTSQTFSQESCMSGASRSIQRATVLGFSKKTSHLYLIQVTHSNNETSLTEKSFDQFAKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHKRFRDLNHYMEQILNGSYEVANSDCVLSFFLSEPVEQAVKESSAVDLGEKFADKKPKVQLVISYKDAKLTILVKHMKNIHLPDGSTPSAHVEFYLLPYPSEARRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTTFVGAINIQLCSVTLNEEKWYPLGNSII", "length": 1487, "header": "tr|A0AAA9THJ4-1|A0AAA9THJ4_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma OS=Bos taurus OX=9913 GN=PIK3C2G PE=3 SV=1 CANONICAL=A0AAA9THJ4-1" }, "locus": { "chromosome": "5", "start_pos": 91842738, "end_pos": 91399889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120307.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120307.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097991.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097991.1" } ] } }, { "isoform_ac": "E1B8D1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4/entry#E1B8D1-1", "sequence": { "sequence": "MAYYWKTDLNSSESHEKQQEHQEFPSLNQPLFSSLVSLGFDNVVEEISNKIPLCQREIEENAFFVPSALHWDSRTHSLDEIHQTSLNEFTSKSSELSCHQVRETPVIGFSRHSVLPNPQNINKGSSWGNPIGKYHGADDYGFNILPLSSTSLDKNNSQSQLENENHNYHIGFESSVLPIYPFLSTNLMPKEENKSRRNMNVVESSLMPFQGSSLPRTWESTHPKNTELTGCSIQLVEVAQGSNMSLASFCNKVKKIRETYHAADMDSNSGKIWSTTTAFPYKLFSNTKFNINIFTDNSTKGLHFIPCANYLVKDLIAEILHFCMNDQLFPRDHLLSICGHEEFLQNDHYLGSHRVFQKNKSVIQLHLQKKRDTPGTLSRKHEDDHSQFYLNQLLEFMHIWKVSRQCLSTVIQKYDSHLKYLLKTQQNVDNVIEEVKSICSVLGCVETKQITDAINELNLILQRKPKNLHQNSDTSAKGLIEKVTTELSTSICQLIDIHCSSFCADFQPLHAPLYSVSCVNLGLHSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESMLTIKLFGITYATNADLLAWTCFPLFPKHRSILGSALFSMTLQSEPPMEMIAPGVWDVSQPSPVTLQIDFPATEWEYMKLDSEENGSDLEEPPKECLKHIARLSQKQTPILLSEEKRRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWKFSHPLEALGLLTSSFPDQEIRNVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSVQIAHRLYWLLKDAQNEAYFKIWYQKLLAALQFCAGKALRDEFSKEQKLIKILGDIGEKVKTASDPQRQEVLKKELGRLEEFFWCTKTCHLPLNPALCVQGIDGDACSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMVIYRCLSTGKGQGLVQMVPDAVTLAKIHRCFGPIGPLKENTIKKWFSQHNPLKADYEKVLRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIVRRHSRLLLNLLEMMLHAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMTAISPAKLTSQTFSQESCMSGASRSIQRATVLGFSKKTSHLYLIQVTHSNNETSLTEKSFDQFAKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHKRFRDLNHYMEQILNGSYEVANSDCVLSFFLSEPVEQAVKESSAVDLGEKFADKKPKVQLVISYKDAKLTILVKHMKNIHLPDGSTPSAHVEFYLLPYPSEARRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTTFVGAINIQLCSVTLNEEKWYPLGNSII", "length": 1446, "header": "tr|E1B8D1-1|E1B8D1_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma OS=Bos taurus OX=9913 GN=PIK3C2G PE=3 SV=3 CANONICAL=A0AAA9THJ4-1" }, "locus": { "chromosome": "5", "start_pos": 91842738, "end_pos": 91399889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043102.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043102.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040697.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040697.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1402, "start_aa": "Thr", "end_pos": 1402, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1402", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513301", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513301", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-BTA-1660514", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FNW6-1", "protein_name": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "gene_name": "PIK3C2G", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAYCWKTDRDSSESHEKQQEHHESHSVNQPLFPSQVSLGFDHIVDEISNKVPLYQREIEKNTIFVPSASSWDSRRHSLDETHQISLNEFISRSSELSCHQGSKTPVIGFSHSVLPDSQRKKKESSWGNPTENYHGADDSRFDILAPPSSGLDKTNSRSELENENHNYHIGFESSIPLIYPTSSNDSMPKEENKRRRNMNIVEPSLMIFKGSLLPRTWESTCPKNIEPTGCTIQLVEVPQGSNMSLASFCDKVKKIRETYHADDINSNSGKIWSTTTAFPYRLFPNTKFNISIFTDNSTQQLHFMPYANYLVKDLIAEILHLCTNDQLSSKDHLLSICGYEEFLQNDQYLGSHRIFQKNKSVLQLTLQKNREAPGKLSRKHADDHSQFYLNQLLQFMHIWKVSRQCLSTVIKKYDFHLRYLLKTQQNMDNMIEEVKNICGVLGCVETKQITDAINELNLILQRKAESFHQNSETSTKGLIEKVTTKLSMSIYQLIDIYCCSFYADFQPLNAPNSVSCVNLGLHSHLSFTVYAAHNIPETWVHSYKAFSFSCWLTYAGKKLCQVRNYRNIPVKKLLFFLVNWNETINFPLEIKALPRESMLTIKLFGVTCATNSADLLAWTCFPLFPKQRYILRSVLFSTTLQDEPPLEMIAPGVWDISQPSPVTLQINFPATEWEYMKLDSQENRSDLEEPPKECLKHISRLSQKQSPLLLSEEKRRYLWFYRFYCNNENCSLPLVLGSAPGWDEKTVSEMHAILRRWKFSHPLDALGLLTSSFPDQEIRKVAVQQLDKLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQIAHRLYWLLKDAQNEAYFKSWYQKLLAALQFCVGKALSDEFSKEKKLIKILGDIGEKVKSASDPQRQEVLKKEIGRLEEFFQGSDTCHLPLNPAVCIKGIDGNACSYFTSNALPLKITFINANPMGRNISVIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMIIYRCLSTGKGQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKVDYEQALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIVRRHSRLLLNLLEMMLHAGLPELSGIQDLKYVYDNLRPQDSDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMTAISPAKSTSQTFSQESCMLSATRSIQKATILGFSKKTNHLYLIQVTHSKNETILTEKSFDQFSKLHSQLQKQFVSWTLPEFPHWWHLPFTNSDHKRFRDLNHYMEQILNGSYEVANSDCVLSFFLSDPVEQAVEELSPVDLGEKFPDKKPKVQLVISYEDAKLTILVKHMKNIHLPDGSVPSAHVEFYLLPYPSEVRRRKTKSVPKCTNPTYNEIVVYDEVTELQGHVLMLIVKSKTTFVGAINIRLCSVLLNEEKWYPLGNNII", "length": 1486 }, "evidence": [ { "id": "A0AAA9THJ4", "url": "https://omabrowser.org/oma/group/A0AAA9THJ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75747-1", "protein_name": "Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma", "gene_name": "PIK3C2G", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLSTTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLGNSII", "length": 1486 }, "evidence": [ { "id": "A0AAA9THJ4", "url": "https://omabrowser.org/oma/group/A0AAA9THJ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-3-kinase activity", "id": "GO:0016303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-4-phosphate 3-kinase activity", "id": "GO:0035005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035005", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "host-mediated perturbation of viral process", "id": "GO:0044788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044788", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate biosynthetic process", "id": "GO:0036092", "url": 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Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9THJ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THJ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1272, "end_pos": 1274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1331, "end_pos": 1333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 684, "end_pos": 686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 730, "end_pos": 732, "annotation": "n_glycosylation_sequon" }, { "start_pos": 957, "end_pos": 959, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12709", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9THJ4-1", "F1MTL5-1", "P32871-1", "E1BE68-1", "E1BE66-1", "A0ABI0NMT8-1" ], "evidence": [ { "id": "12709", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12709" } ] }, { "id": "18373", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9THJ4-1", "E1BE68-1", "A0ABI0NMT8-1" ], "evidence": [ { "id": "18373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18373" } ] }, { "id": "R-BTA-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [ "R-ALL-1806217" ], "output_participant_list": [], "enzyme_list": [ "E1BE68-1", "A0AAA9THJ4-1" ], "evidence": [ { "id": "R-BTA-1675928", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1675928" } ] }, { "id": "R-BTA-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "F1MYM3-1", "E1BE66-1", "E1BE68-1", "A0AAA9THJ4-1" ], "evidence": [ { "id": "R-BTA-1676109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1676109" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1806217", "participant_name": "PI4P [Golgi membrane]", "crossref": [ { "id": "17526", "database": "ChEBI", "url": "" }, { "id": "C01277", "database": "COMPOUND", "url": "" }, { "id": "4496", "database": "PubChem Substance", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9THJ4", "gene_name": "PIK3C2G", "activity": [ { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "E1BE66", "gene_name": "PIK3CD", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "E1BE66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE66" } ] } ] }, { "uniprot_ac": "E1BE68", "gene_name": "PIK3C2A", "activity": [ { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "E1BE68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BE68" } ] } ] }, { "uniprot_ac": "F1MTL5", "gene_name": "PIK3C3", "activity": [ { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "F1MTL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 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"binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEN1-1", "uniprot_ac": "A0AAA9TEN1", "uniprot_id": "A0AAA9TEN1_BOVIN", "mass": { "chemical_mass": 33596.0, "monoisotopic_mass": 33596.0 }, "refseq": { "ac": "XP_005228655", "name": "deubiquitinase OTUD6B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228655" }, "gene_names": [ { "name": "OTUD6B", "type": "recommended", "evidence": [ { "id": "A0AAA9TEN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1" } ] }, { "name": "OTUD6B", "type": "synonym", "evidence": [ { "id": "XP_005228655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228655" } ] } ], "protein_names": [ { "name": "ubiquitinyl hydrolase 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TEN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "A0AAA9TEN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#names_and_taxonomy" } ] }, { "name": "deubiquitinase OTUD6B", "type": "synonym", "evidence": [ { "id": "XP_005228655", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228655" } ] } ], "function": [ { "annotation": "Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1T2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T2#function" }, { "database": "UniProtKB", "id": "ARBA00049970", "url": "https://www.uniprot.org/uniprotkb/ARBA00049970#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OTUD6B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1", "locus": { "chromosome": "14", "start_pos": 73242822, "end_pos": 73339694, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003481", "url": "https://www.ensembl.org/id/ENSBTAG00000003481" } ] } } ], "crossref": [ { "id": "A0AAA9TEN1", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEN1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003481", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22761", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22761", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100847538", "url": "https://www.ncbi.nlm.nih.gov/gene/100847538", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100847538", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847538", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "bta:617064", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617064", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YELGAHY", "url": "https://omabrowser.org/oma/group/YELGAHY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12419:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02338", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02338", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228655", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228655", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S0L6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1T2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1T2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0N7", "url": "https://www.uniprot.org/uniprotkb/F1N0N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0N7-1", "url": "https://www.uniprot.org/uniprotkb/F1N0N7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAVLTEELDEEEQLVRRHRKEKKELQAKIQSMKNAVPRNDKKRRKQLTEDVAKLEAEMEQKHREELDQLKLTSKESKIDSVAVNISNLVLENQPLRISKAQKRRDKKAALEKEREERIAEAEIENLTGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIEDQLKEQNGVLTVAALRCQTANYMQSHVEDFLPFLTNPNTGEMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILRTPIEIIQADSPPIVVGEEYPENPLILVYMRHAYGLGEHYNSVTRLVNTATENCS", "length": 293, "header": "tr|A0AAA9TEN1-1|A0AAA9TEN1_BOVIN Isoform 1 of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0L6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#A0AAA9S0L6-1", "sequence": { "sequence": "MNEAKETPVPSLGGEDPLEEKMAPHSTIPARRIPRSKEPDSPWGRKEQDNTEPLSENCRYCFLAFTVAREKCEIDSVAVNISNLVLENQPLRISKAQKRRDKKAALEKEREERIAEAEIENLTGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIEDQLKEQNGVLTVAALRCQTANYMQSHVEDFLPFLTNPNTGEMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILRTPIEIIQADSPPIVVGEEYPENPLILVYMRHAYGLGEHYNSVTRLVNTATENCS", "length": 288, "header": "tr|A0AAA9S0L6-1|A0AAA9TEN1_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73339495, "end_pos": 73324078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104296.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104296.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078521.1" } ] } }, { "isoform_ac": "A0AAA9S0P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#A0AAA9S0P2-1", "sequence": { "sequence": "MIFTDKKAALEKEREERIAEAEIENLTGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIEDQLKEQNGVLTVAALRCQTANYMQSHVEDFLPFLTNPNTGEMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILRTPIEIIQADSPPIVVGEEYPENPLILVYMRHAYGLGEHYNSVTRLVNTATENCS", "length": 192, "header": "tr|A0AAA9S0P2-1|A0AAA9TEN1_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73331031, "end_pos": 73324078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092250.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092250.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079431.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079431.1" } ] } }, { "isoform_ac": "A0AAA9SEU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#A0AAA9SEU4-1", "sequence": { "sequence": "MAERLLIRALKGGKNTKIVILNGKNITKMPSVLEKLPGLKTLYLQNNQISKVCPEISNLTQFQDLKLREFYCEGNPLFLKQPVSAIKQEDVWSLQEITSRFIMNQLAEKNPFLMKAIKWYPQVRSIISQGRKCAICEKFFLTIWLECVEFFPPSKNWKISRNLQLVPLRILICSYKCFYQRNPNIFGIAQV", "length": 191, "header": "tr|A0AAA9SEU4-1|A0AAA9TEN1_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73316366, "end_pos": 73243052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135234.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135234.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083917.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083917.1" } ] } }, { "isoform_ac": "A0AAA9T1T2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#A0AAA9T1T2-1", "sequence": { "sequence": "MAERLLIRALKGGKNTKIVILNGKNITKMPSVLEKLPGLKTLYLQNNQISKVCPEISNLTQLTALNLGNNLLEEVPEEMKYLTSLKKLHLFRNKIHRFASGVCDGLQSLILLNLNNNQLTWIPQEISRLKNLRCLSINHNQLASIPRELCFLENLSELQLNYNQLVCIPKEIKFLKKLRKLLLSRNNIKSLPEGLCNLFNLRILDVAGNVIQMFPPGFQDLKLREFYCEGNPLFLKQPVSAIKQEDVWSLQEITSRFIMNQLAEKNPFLMKAIKWYPQVRSIISQGRKCAICEKFFLTIWLECVEFFPPSKNWKISRNLQLVPLRILICSYKCFYQRNPNIFGIAQV", "length": 347, "header": "tr|A0AAA9T1T2-1|A0AAA9TEN1_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73316366, "end_pos": 73243052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091698.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091698.1" } ] } }, { "isoform_ac": "A0AAA9TEN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#A0AAA9TEN1-1", "sequence": { "sequence": "MEAVLTEELDEEEQLVRRHRKEKKELQAKIQSMKNAVPRNDKKRRKQLTEDVAKLEAEMEQKHREELDQLKLTSKESKIDSVAVNISNLVLENQPLRISKAQKRRDKKAALEKEREERIAEAEIENLTGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIEDQLKEQNGVLTVAALRCQTANYMQSHVEDFLPFLTNPNTGEMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILRTPIEIIQADSPPIVVGEEYPENPLILVYMRHAYGLGEHYNSVTRLVNTATENCS", "length": 293, "header": "tr|A0AAA9TEN1-1|A0AAA9TEN1_BOVIN Isoform 1 of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=1 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73338173, "end_pos": 73324078, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097063.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097063.1" } ] } }, { "isoform_ac": "F1N0N7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1/entry#F1N0N7-1", "sequence": { "sequence": "MEAVLTEELDEEEQLVRRHRKEKKELQAKIQSMKNAVPRNDKKRRKQLTEDVAKLEAEMEQKHREELDQLKLTSKESKIDSVAVNISNLVLENQPLRISKAQKRRDKKAALEKEREERIAEAEIENLTGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIEDQLKEQNGVLTVAALRCQTANYMQSHVEDFLPFLTNPNTGEMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILRTPIEIIQADSPPIVVGEEYPENPLILVYMRHAYGLGEHYNSVTR", "length": 283, "header": "tr|F1N0N7-1|F1N0N7_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=OTUD6B PE=4 SV=3 CANONICAL=A0AAA9TEN1-1" }, "locus": { "chromosome": "14", "start_pos": 73338173, "end_pos": 73283619, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004524.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004524.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004524.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004524.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100847538", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100847538", "resource": "KEGG Pathway" }, { "id": "bta:617064", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617064", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P38747-1", "protein_name": "OTU domain-containing protein 2", "gene_name": "OTU2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTGMESGENLENMEDILARHRKENKDLQNKITGMKKQATKSKRKEVNSKCLDLQDKLKTKQENEIRDWKIANNEVFDAEQEDEVTPEKLLEQLSISRDEKEQQNVPVQQQQQGQTKKRRNRQKERLAKRDAAIAKMKEEAALEASKQPDLKKMEQESIDQLCELKKLKQFDIQPDGHCLFASILDQLKLRHDPKKLDQDMDVMKLRWLSCNYVQEHRDDFIPYLFDEETMKMKDIDEYTKEMEHTAQWGGEIEILALSHVFDCPISILMSGRPIQVYNECGKNPELKLVYYKHSYALGEHYNSLHDS", "length": 307 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54WV5-1", "protein_name": "OTU domain containin protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGKKKTNKLVVNLSDDEENEIKNEENIKKDDEKSEENNDNNDNNSDNSDDDDDDDGDNTEKVETKGKMVQRHKMEIKKLQQQIDKLNHAIPKKDKKAKSDLLEKTKKMEDDLKKKHQQELEQCEKLNKTTQSIEELNLEQQQLQQKQPSKAYLKKAQKLKQEEERMKQLEEDRKNHVSKGVIEMNDFLAKLKPLNKTVKFIPPDGDCLYQAITNQLLINKDINEEESKSYAKKLRTIASDYIKNNRDEFLPFIISEDEYSTAEDPIQEYCQEQVLTIGKWGGHIELKALSQSLKKVITIFNAYSNDIIIGEEFTNPIYLTYHRHAFTLGEHYNSAIPISN", "length": 340 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZIP6-1", "protein_name": "Deubiquitinase OTUD6B", "gene_name": "OTUD6B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEGSEDEEAEAGGPLQQLVKRQRREKRELQAKIQGMKNAVPKNDKKRRKQLAEEVAKLEAELEQKHKEELKQLKEAMPEQNKIDSIADGVANFELEGREQQIQHPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHLESQKLASLLAARHLEIKQIPSDGHCMYRAIEDQLKDHHNSWTVATLRNQTAKYIHSHFDDFLPFLTNPNTGDMYSKEEFEKYCDDIANTAAWGGQLELRALSHILQTPIEVVQMDSPSIIVGEEYSGKPIILVYMRHAYGLGEHYNSVKLLTDATTENGS", "length": 302 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8K2H2-1", "protein_name": "Deubiquitinase OTUD6B", "gene_name": "Otud6b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEVVAEELDDEEQLVRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEREMEQKHREELEQLKQLTFKDSKIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLSGARHLESEKLAQILAARELEIKQIPSDGHCMYGALEDQLREQDCALTVASLRRQTAEYMQTHSDDFLPFLTNPSTGDMYTPEEFGKYCDDIVNTAAWGGQLELRALSHILQTPIEILQADAPPIIVGEEYPRNPLVLVYMRHAYGLGEHYNSVTRLVNSATENCS", "length": 294 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N6M0-1", "protein_name": "Deubiquitinase OTUD6B", "gene_name": "OTUD6B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS", "length": 293 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VUN9-1", "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "Otud6", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCDGDVAIAELESRLDEVSLEDIGARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKAELKAAEAMEAPVLVEPVVKEPAEKPETEVTDDDGIEEKEEQLAPNQRVSKAQKRRDKKAKEARAREAEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSIRHQLIVNALPGHSVQELREETANYVRAHKDSLISYMIHPETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVPIEVIQAEGAPTLLGQEEFGGSPLIICYHRHIYQLGAHYNSTVPAA", "length": 312 }, "evidence": [ { "id": "A0AAA9TEN1", "url": "https://omabrowser.org/oma/group/A0AAA9TEN1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEN1" }, { "id": "PS50802", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50802" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "OTU", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 284, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 85, "end_pos": 87 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TGT5-1", "uniprot_ac": "A0AAA9TGT5", "uniprot_id": "A0AAA9TGT5_BOVIN", "mass": { "chemical_mass": 49616.0, "monoisotopic_mass": 49616.0 }, "refseq": {}, "gene_names": [ { "name": "WNT5B", "type": "recommended", "evidence": [ { "id": "A0AAA9TGT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ] } ], "protein_names": [ { "name": "Protein Wnt", "type": "recommended", "evidence": [ { "id": "A0AAA9TGT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S0P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0P4#function" }, { "database": "UniProtKB", "id": "RU003500", "url": "https://www.uniprot.org/uniprotkb/RU003500#function" }, { "database": "UniProtKB", "id": "A0AAA9SA46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA46#function" }, { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WNT5B", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5", "locus": { "chromosome": "5", "start_pos": 108150846, "end_pos": 108071181, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057245", "url": "https://www.ensembl.org/id/ENSBTAG00000057245" } ] } } ], "crossref": [ { "id": "A0AAA9TGT5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TGT5", "database": "AlphaFoldDB", "categories": [] }, { "id": "508008", "url": "https://www.ncbi.nlm.nih.gov/gene/508008", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508008", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508008", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQVERCH", "url": "https://omabrowser.org/oma/group/IQVERCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S0P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARCMMPVSLMLSHERRLRLRRLPMCDRCRSPASEMPPQKLRLRSLRPVSPREMCFRDREPHLGSRRSPGSSPALGGAGRRRTMPSLPALLALLFACWAPLRATASSWWSLAMSPVQRPEMFIIGAQPVCSQLPGLSAGQRKLCQLYQEHMAYIGEGARTGIRECQHQFRQRRWNCSTVDDASVFGRVLQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVDYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKTADVACKCHGVSGSCSLKTCWLQLAEFRKVGDQLKEKYDSAAAMRITRRGKLELVNSRFKPPTPEDLVYVDPSPDYCLRDESTGSLGTRGRLCNKTSEGLDGCALMCCGRGYNQFKSVRTERCHCKFHWCCFVRCKKCTQVVDQFVCK", "length": 441, "header": "tr|A0AAA9TGT5-1|A0AAA9TGT5_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT5B PE=3 SV=1 CANONICAL=A0AAA9TGT5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5/entry#A0AAA9S0P4-1", "sequence": { "sequence": "MPSLPALLALLFACWAPLRATASSWWSLAMSPVQRPEMFIIGAQPVCSQLPGLSAGQRKLCQLYQEHMAYIGEGARTGIRECQHQFRQRRWNCSTVDDASVFGRVLQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVDYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKTADVACKCHGVSGSCSLKTCWLQLAEFRKVGDQLKEKYDSAAAMRITRRGKLELVNSRFKPPTPEDLVYVDPSPDYCLRDESTGSLGTRGRLCNKTSEGLDGCALMCCGRGYNQFKSVRTERCHCKFHWCCFVRCKKCTQVVDQFVCK", "length": 358, "header": "tr|A0AAA9S0P4-1|A0AAA9TGT5_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT5B PE=3 SV=1 CANONICAL=A0AAA9TGT5-1" }, "locus": { "chromosome": "5", "start_pos": 108150705, "end_pos": 108138585, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114971.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114971.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075641.1" } ] } }, { "isoform_ac": "A0AAA9SA46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5/entry#A0AAA9SA46-1", "sequence": { "sequence": "MEPHLGSRRSPGSSPALGGAGRRRTMPSLPALLALLFACWAPLRATASSWWSLAMSPVQRPEMFIIGAQPVCSQLPGLSAGQRKLCQLYQEHMAYIGEGARTGIRECQHQFRQRRWNCSTVDDASVFGRVLQIGCVQDGRRGLQMPWRLWVLQSQDLLAAAGRVPQGGGPAKGEVRQRGRHAHHPPRKAGASQQPLQAAHP", "length": 201, "header": "tr|A0AAA9SA46-1|A0AAA9TGT5_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT5B PE=3 SV=1 CANONICAL=A0AAA9TGT5-1" }, "locus": { "chromosome": "5", "start_pos": 108150452, "end_pos": 108122371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129315.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129315.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082193.1" } ] } }, { "isoform_ac": "A0AAA9TGT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5/entry#A0AAA9TGT5-1", "sequence": { "sequence": "MARCMMPVSLMLSHERRLRLRRLPMCDRCRSPASEMPPQKLRLRSLRPVSPREMCFRDREPHLGSRRSPGSSPALGGAGRRRTMPSLPALLALLFACWAPLRATASSWWSLAMSPVQRPEMFIIGAQPVCSQLPGLSAGQRKLCQLYQEHMAYIGEGARTGIRECQHQFRQRRWNCSTVDDASVFGRVLQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVDYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKTADVACKCHGVSGSCSLKTCWLQLAEFRKVGDQLKEKYDSAAAMRITRRGKLELVNSRFKPPTPEDLVYVDPSPDYCLRDESTGSLGTRGRLCNKTSEGLDGCALMCCGRGYNQFKSVRTERCHCKFHWCCFVRCKKCTQVVDQFVCK", "length": 441, "header": "tr|A0AAA9TGT5-1|A0AAA9TGT5_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT5B PE=3 SV=1 CANONICAL=A0AAA9TGT5-1" }, "locus": { "chromosome": "5", "start_pos": 108150705, "end_pos": 108112796, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097411.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:508008", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508008", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M064-1", "protein_name": "Protein Wnt", "gene_name": "Wnt5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKCMMPVSLMLSQERRLRLRRLPMCDRCRRPASEIPPQKLRLRSLRPVSPREMCFRERSGAPLWKMLVPGHWDGLRPAMPSLLLLFVAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNLSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAGRRAVYKMADVSCKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELTNSRFNQPSPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGTDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEIVDQYVCK", "length": 438 }, "evidence": [ { "id": "A0AAA9TGT5", "url": "https://omabrowser.org/oma/group/A0AAA9TGT5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NMK6-1", "protein_name": "Protein Wnt", "gene_name": "WNT5B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQGAPCRRPPPRGLPQRRRRPQPTMTGPRLALAAALLCSCTSPVADANSWWSLAMNPIQRPEMYIIGAQPVCSQLPGLSPGQRKLCQLYQEHMVFIGEGARSAIKECQYQFRQRRWNCSTVDNTSVFGRVMKIGSRETAFTYAVSAAGVVNAISRACREGELSSCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAKEREKNYVRGSEEQARMLMNLQNNEAGRRAVYKLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRISRKGKLELVNNRFNMPTQEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKSVQVERCHCKFHWCCYVKCKKCTEIVDQYVCK", "length": 383 }, "evidence": [ { "id": "A0AAA9TGT5", "url": "https://omabrowser.org/oma/group/A0AAA9TGT5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P22726-1", "protein_name": "Protein Wnt-5b", "gene_name": "Wnt5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSLLLVVVAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMSYIGEGAKTGIRECQHQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRALMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRITRQGKLELANSRFNQPTPEDLVYVDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDRFKSVQVERCHCRFHWCCFVRCKKCTEVVDQYVCK", "length": 359 }, "evidence": [ { "id": "A0AAA9TGT5", "url": "https://omabrowser.org/oma/group/A0AAA9TGT5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92050-1", "protein_name": "Protein Wnt-5b", "gene_name": "wnt5b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDVRMNQGHLLLAVTLIVCNSQLLVVANSWWSLAMNPIQRPEMYIIGAQPLCSQLTGLSQGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMHIGSRETAFTYAVSAAGVVNAVSRACREGELSTCGCSRAARPRDLPRDWLWGGCGDNVNYGYRFAREFVDAREREKNYPRGSVEHARTLMNLQNNEAGRMAVYNLANVACKCHGVSGSCSLKTCWLQLADFRRVGEFLKEKYDSAAAMRINRRGKLELVNNRFNPPTGEDLVYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTYKHERCHCKFHWCCYVKCKRCTSLVDQFVCK", "length": 363 }, "evidence": [ { "id": "A0AAA9TGT5", "url": "https://omabrowser.org/oma/group/A0AAA9TGT5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9H1J7-1", "protein_name": "Protein Wnt-5b", "gene_name": "WNT5B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSLLLLFTAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK", "length": 359 }, "evidence": [ { "id": "A0AAA9TGT5", "url": "https://omabrowser.org/oma/group/A0AAA9TGT5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" }, { "name": "chondrocyte differentiation", "id": "GO:0002062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002062", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGT5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 }, { "start_pos": 387, "end_pos": 389 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TGZ9-1", "uniprot_ac": "A0AAA9TGZ9", "uniprot_id": "A0AAA9TGZ9_BOVIN", "mass": { "chemical_mass": 32256.0, "monoisotopic_mass": 32256.0 }, "refseq": {}, "gene_names": [ { "name": "SNX11", "type": "recommended", "evidence": [ { "id": "A0AAA9TGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ] } ], "protein_names": [ { "name": "Sorting nexin 11", "type": "synonym", "evidence": [ { "id": "A0AAA9TGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9", "locus": { "chromosome": "19", "start_pos": 38358273, "end_pos": 38385093, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020321", "url": "https://www.ensembl.org/id/ENSBTAG00000020321" } ] } } ], "crossref": [ { "id": "A0AAA9TGZ9", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TGZ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd06898", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06898", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043544", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043544", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46209", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46209", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46209:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46209:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S135", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S135", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S135-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S135-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ33", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZ33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZ33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z859", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z859", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z859-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z859-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFWCRMLENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSSSLQGTVVSCCSDQVGIGLTSVAAGEVTQEDNHFALSNGWIWSWKAGTSNLKIDKLGPFMLKMMKRATFVGDSAPDSEQSQFASFRSGETGSTSTSKGGNKGPDTAGREV", "length": 290, "header": "tr|A0AAA9TGZ9-1|A0AAA9TGZ9_BOVIN Isoform 1 of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S135-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#A0AAA9S135-1", "sequence": { "sequence": "MGFWCRMLENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKRDHSRLLGLTHAWQHPALAVMPGVEAEPGEGAVCQLEQGAKRRQTRPSRTPAKAGLPGSAPLLEGSTDPADHRGSSLTTAVRTAKSGINSLPFKTKKQAEV", "length": 280, "header": "tr|A0AAA9S135-1|A0AAA9TGZ9_BOVIN Computationally mapped isoform of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "locus": { "chromosome": "19", "start_pos": 38381392, "end_pos": 38358699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100206.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100206.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078688.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078688.1" } ] } }, { "isoform_ac": "A0AAA9STM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#A0AAA9STM4-1", "sequence": { "sequence": "MGFWCRMLENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSCCFLPRPGRRSSPSPPPGEEKDPFEAGIGANVPKTEGNWFPLVHLRICCHLAVASPLAHCFLSPVA", "length": 246, "header": "tr|A0AAA9STM4-1|A0AAA9TGZ9_BOVIN Computationally mapped isoform of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "locus": { "chromosome": "19", "start_pos": 38381392, "end_pos": 38367799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123581.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123581.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087488.1" } ] } }, { "isoform_ac": "A0AAA9TGZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#A0AAA9TGZ9-1", "sequence": { "sequence": "MGFWCRMLENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSSSLQGTVVSCCSDQVGIGLTSVAAGEVTQEDNHFALSNGWIWSWKAGTSNLKIDKLGPFMLKMMKRATFVGDSAPDSEQSQFASFRSGETGSTSTSKGGNKGPDTAGREV", "length": 290, "header": "tr|A0AAA9TGZ9-1|A0AAA9TGZ9_BOVIN Isoform 1 of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "locus": { "chromosome": "19", "start_pos": 38381392, "end_pos": 38373380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133931.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133931.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097500.1" } ] } }, { "isoform_ac": "A0AAA9TZ33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#A0AAA9TZ33-1", "sequence": { "sequence": "MGFWCRMLENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSCCFLPRPGRRSSPSPPPGEEKDPFEVPQIRDPWEAARTALWLALRSALFRQRQRSWTPHLLLAS", "length": 244, "header": "tr|A0AAA9TZ33-1|A0AAA9TZ33_BOVIN Computationally mapped isoform of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "locus": { "chromosome": "19", "start_pos": 38381392, "end_pos": 38372627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127911.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127911.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103907.1" } ] } }, { "isoform_ac": "A0AAF6Z859-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9/entry#A0AAF6Z859-1", "sequence": { "sequence": "MGFWCRMLENQEQEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGSSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSPVSVSDAILRYAMSNCGWAQEERRGSSHLAEGDQPKSCCFLPRPGRRSSPSPPPGEEKDPFEVWAPVVDSEAPPLESPTLPPTSSPSCCGFARPDEGLSASQPVRRVLGGGHAVPLDPGQLETVLEK", "length": 269, "header": "tr|A0AAF6Z859-1|A0AAF6Z859_BOVIN Computationally mapped isoform of Sorting nexin 11 OS=Bos taurus OX=9913 GN=SNX11 PE=3 SV=1 CANONICAL=A0AAA9TGZ9-1" }, "locus": { "chromosome": "19", "start_pos": 38381392, "end_pos": 38377645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027082.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027082.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027082.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027082.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" }, { "name": "vesicle organization", "id": "GO:0016050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016050", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGZ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TGZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ9" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 132, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TG35-1", "uniprot_ac": "A0AAA9TG35", "uniprot_id": "A0AAA9TG35_BOVIN", "mass": { "chemical_mass": 18094.0, "monoisotopic_mass": 18094.0 }, "refseq": {}, "gene_names": [ { "name": "LY6K", "type": "recommended", "evidence": [ { "id": "A0AAA9TG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35" } ] } ], "protein_names": [ { "name": "Lymphocyte antigen 6 family member K", "type": "synonym", "evidence": [ { "id": "A0AAA9TG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LY6K", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35", "locus": {} } ], "crossref": [ { "id": "A0AAA9TG35", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TG35", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd23550", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23550", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100848249", "url": "https://www.ncbi.nlm.nih.gov/gene/100848249", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052874", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052874", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100848249", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848249", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPFFYLK", "url": "https://omabrowser.org/oma/group/MPFFYLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR15049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15049:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15049:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00021", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00021", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S364", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S364", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S364-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S364-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSQDQASLEMITLLALLLVLGLPQVASNLTVSGRQDAVLRCHVCEKENSFECQGPENCDNGSTYCISAAVRVFPRFFLISKQCALNCGMNEAFSQMARSFVLVKPTPFLYLACCTSSLCNIQKPIIRENTEDAYLKFIKGQGWGSSSGLMPFLTLASALLGLRLP", "length": 166, "header": "tr|A0AAA9TG35-1|A0AAA9TG35_BOVIN Isoform 1 of Lymphocyte antigen 6 family member K OS=Bos taurus OX=9913 GN=LY6K PE=4 SV=1 CANONICAL=A0AAA9TG35-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S364-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35/entry#A0AAA9S364-1", "sequence": { "sequence": "MITLLALLLVLGLPQVASNLTVSGRQDAVLRCHVCEKENSFECQGPENCDNGSTYCISAAVRVFPRFFLISKQCALNCGMNEAFSQMARSFVLVKPTPFLYLACCTSSLCNIQKPIIRENTEDAYLKFIKGQGWGSSSGLMPFLTLASALLGLRLP", "length": 156, "header": "tr|A0AAA9S364-1|A0AAA9TG35_BOVIN Computationally mapped isoform of Lymphocyte antigen 6 family member K OS=Bos taurus OX=9913 GN=LY6K PE=4 SV=1 CANONICAL=A0AAA9TG35-1" }, "locus": { "chromosome": "14", "start_pos": 1619667, "end_pos": 1617086, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090727.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090727.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079543.1" } ] } }, { "isoform_ac": "A0AAA9TG35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35/entry#A0AAA9TG35-1", "sequence": { "sequence": "MGSQDQASLEMITLLALLLVLGLPQVASNLTVSGRQDAVLRCHVCEKENSFECQGPENCDNGSTYCISAAVRVFPRFFLISKQCALNCGMNEAFSQMARSFVLVKPTPFLYLACCTSSLCNIQKPIIRENTEDAYLKFIKGQGWGSSSGLMPFLTLASALLGLRLP", "length": 166, "header": "tr|A0AAA9TG35-1|A0AAA9TG35_BOVIN Isoform 1 of Lymphocyte antigen 6 family member K OS=Bos taurus OX=9913 GN=LY6K PE=4 SV=1 CANONICAL=A0AAA9TG35-1" }, "locus": { "chromosome": "14", "start_pos": 1619667, "end_pos": 1613003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090193.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090193.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097524.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100848249", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100848249", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ALH7-1", "protein_name": "Lymphocyte antigen 6 family member K", "gene_name": "LY6K", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKALLALFLVVGLPRAETNVTVSGRQNVAMRCYVCETENNFLCTQESNCTRGSRFCTTVAVRVFPRFYLVSKQCVAACAFEGVQQRGAKSFLLIKPTPFLYVVCCQERLCNTHNPVIEENSEDKYKEVAGACDGLGGRVGLAALLTLASVLLDLWLP", "length": 157 }, "evidence": [ { "id": "A0AAA9TG35", "url": "https://omabrowser.org/oma/group/A0AAA9TG35/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZNV7-1", "protein_name": "Lymphocyte antigen 6 family member K", "gene_name": "Ly6k", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGPKGTLRHGLPRKTRHPLEMVILLALLIAVGLPLVKTNVDDEEEKITCHVCESESNLNCSNPKACDSGKKFCLLAVTRIFERFFYVSKQCTQLCPTPPLFFAETPSEPKGFLVEKPLPFLFVKCCKWDLCNEKFPVSITMLKQESGKASERRHRYTELLLPGFMVLTANGLSALSLL", "length": 179 }, "evidence": [ { "id": "A0AAA9TG35", "url": "https://omabrowser.org/oma/group/A0AAA9TG35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q17RY6-1", "protein_name": "Lymphocyte antigen 6K", "gene_name": "LY6K", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALLALLLVVALPRVWTDANLTARQRDPEDSQRTDEGDNRVWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRYCNLEGPPINSSVFKEYAGSMGESCGGLWLAILLLLASIAAGLSLS", "length": 165 }, "evidence": [ { "id": "A0AAA9TG35", "url": "https://omabrowser.org/oma/group/A0AAA9TG35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG35" }, { "id": "PF00087", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00087" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Snake toxin/toxin-like", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 121, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 29, "end_pos": 31 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEC8-1", "uniprot_ac": "A0AAA9TEC8", "uniprot_id": "A0AAA9TEC8_BOVIN", "mass": { "chemical_mass": 127423.0, "monoisotopic_mass": 127423.0 }, "refseq": {}, "gene_names": [ { "name": "LRIG1", "type": "recommended", "evidence": [ { "id": "A0AAA9TEC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8" } ] } ], "protein_names": [ { "name": "Leucine rich repeats and immunoglobulin like domains 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TEC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRIG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8", "locus": { "chromosome": "22", "start_pos": 35067972, "end_pos": 34953601, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010360", "url": "https://www.ensembl.org/id/ENSBTAG00000010360" } ] } } ], "crossref": [ { "id": "A0AAA9TEC8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505750", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505750", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTDCMET", "url": "https://omabrowser.org/oma/group/CTDCMET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01463", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01463", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S5P1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5P1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA15", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SA15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA15-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPVRGALGAPRRSPCLLLLWLLLLLQLEPASATAGPRAPCAAACTCAGDYLDCGGRGLAALPGDLPAWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGSASSHIVSLFLQHNRIRSVEGRQLKAYLSLHVLDLSANNITEIRSTCFPHGLPLTELNLASNRISTLESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISKLTDGAFWGLARMHALHLEYNSLAEVNSGSLYGLTALHQLHLGNNSISRIHRDGWSFCQKLHELILSFNNLTRLDEESLADLSSLSILRLSHNSISHIAEGAFRGLKSLRVLDLDHNEISGTIEDTSGAFTGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGENAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLLGRTLQSFVTATCAHPEALKGQSIFSVPPESFVCGAEVPGRCASCCLLSPWSARNLGDDILGKELPKQASCLPPEPVRQCGSSPRASRPYCRCFSRGPHAWLPYSRTEEPRPPRFSDDLPKPQIITQPETITAVVGKDVRFTCSAASSSSSPMTFAWKKDNEALANADMENFAHVRAQDGEVMEYTTVLHLRRLSFEHEGRYQCVITNHFGSSYSHKAKLTVHVFPSFTKMPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIGDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVSVGETVALQCKAAGSPPPRITWLKGDRPLSLTERHHFTPGNQLLVVQNVVLEDAGRYTCEMSNALGTERAHSQLSVLPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETMVRMEGGHQANGHLESNGVCPRDAGLFPEVEAHGVICRQPKFCVGFTKEPWKVVEKADGPPGPQKTMERSGPVGCSDCSADAHAYSQEPACRLQPGDSRQPGTSSSQEPSLSEHPHSALHPSRGPLYPSNHDRTRAALKRPAAPLDGKGASSWTLARLCEPDSLDLQPSSVLTAGKPELADAASGSPDVPGEGQHLLLSNGHIPQACDSGSESTPLTGQSPGRRSTPLLFAPKS", "length": 1172, "header": "tr|A0AAA9TEC8-1|A0AAA9TEC8_BOVIN Isoform 1 of Leucine rich repeats and immunoglobulin like domains 1 OS=Bos taurus OX=9913 GN=LRIG1 PE=4 SV=1 CANONICAL=A0AAA9TEC8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5P1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8/entry#A0AAA9S5P1-1", "sequence": { "sequence": "MARPVRGALGAPRRSPCLLLLWLLLLLQLEPASATAGPRAPCAAACTCAGDYLDCGGRGLAALPGDLPAWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGSASSHIVSLFLQHNRIRSVEGRQLKAYLSLHVLDLSANNITEIRSTCFPHGLPLTELNLASNRISTLESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISKLTDGAFWGLARMHALILSFNNLTRLDEESLADLSSLSILRLSHNSISHIAEGAFRGLKSLRVLDLDHNEISGTIEDTSGAFTGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGENAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLLGRTLQSFVTATCAHPEALKGQSIFSVPPESFVCDDLPKPQIITQPETITAVVGKDVRFTCSAASSSSSPMTFAWKKDNEALANADMENFAHVRAQDGEVMEYTTVLHLRRLSFEHEGRYQCVITNHFGSSYSHKAKLTVHVFPSFTKMPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIGDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVSVGETVALQCKAAGSPPPRITWLKGDRPLSLTERHHFTPGNQLLVVQNVVLEDAGRYTCEMSNALGTERAHSQLSVLPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETMVRMEGGHQANGHLESNGVCPRDAGLFPEVEAHGVICRQPKFCVGFTKEPWKVVEKADGPPGPQKTMERSGPVGCSDCSADAHAYSQEPACRLQPGDSRQPGTSSSQEPSLSEHPHSALHPSRGPLYPSNHDRTRAALKRPAAPLDGKGASSWTLARLCEPDSLDLQPSSVLTAGKPELADAASGSPDVPGEGQHLLLSNGHIPQACDSGSESTPLTGQSPGRRSTPLLFAPKS", "length": 1042, "header": "tr|A0AAA9S5P1-1|A0AAA9TEC8_BOVIN Computationally mapped isoform of Leucine rich repeats and immunoglobulin like domains 1 OS=Bos taurus OX=9913 GN=LRIG1 PE=4 SV=1 CANONICAL=A0AAA9TEC8-1" }, "locus": { "chromosome": "22", "start_pos": 35066968, "end_pos": 34953800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128946.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128946.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079164.1" } ] } }, { "isoform_ac": "A0AAA9SA15-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8/entry#A0AAA9SA15-1", "sequence": { "sequence": "MARPVRGALGAPRRSPCLLLLWLLLLLQLEPASATAGPRAPCAAACTCAGDYLDCGGRGLAALPGDLPAWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGSASSHIVSLFLQHNRIRSVEGRQLKAYLSLHVLDLSANNITEIRSTCFPHGLPLTELNLASNRISTLESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISKLTDGAFWGLARMHALHLEYNSLAEVNSGSLYGLTALHQLHLGNNSISRIHRDGWSFCQKLHELILSFNNLTRLDEESLADLSSLSILRLSHNSISHIAEGAFRGLKSLRVLDLDHNEISGTIEDTSGAFTGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGENAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLLGRTLQSFVTATCAHPEALKGQSIFSVPPESFVCDDLPKPQIITQPETITAVVGKDVRFTCSAASSSSSPMTFAWKKDNEALANADMENFAHVRAQDGEVMEYTTVLHLRRLSFEHEGRYQCVITNHFGSSYSHKAKLTVHVFPSFTKMPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIGDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVSVGETVALQCKAAGSPPPRITWLKGDRPLSLTERHHFTPGNQLLVVQNVVLEDAGRYTCEMSNALGTERAHSQLSVLPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETMVRMEGGHQANGHLESNGVCPRDAGLFPEVEAHGVICRQPKFCVGFTKEPWKVVEKADGPPGPQKTMERSGPVGCSDCSADAHAYSQEPACRLQPGDSRQPGTSSSQEPSLSEHPHSALHPSRGPLYPSNHDRTRAALKRPAAPLDGKGKPELADAASGSPDVPGEGQHLLLSNGHIPQACDSGSESTPLTGQSPGRRSTPLLFAPKS", "length": 1064, "header": "tr|A0AAA9SA15-1|A0AAA9TEC8_BOVIN Computationally mapped isoform of Leucine rich repeats and immunoglobulin like domains 1 OS=Bos taurus OX=9913 GN=LRIG1 PE=4 SV=2 CANONICAL=A0AAA9TEC8-1" }, "locus": { "chromosome": "22", "start_pos": 35066968, "end_pos": 34953800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123276.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123276.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080765.2", "url": "https://www.ensembl.org/id/ENSBTAP00000080765.2" } ] } }, { "isoform_ac": "A0AAA9SIZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8/entry#A0AAA9SIZ6-1", "sequence": { "sequence": "MSLLTHLSSCYKYHNFLERFKRNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGSASSHIVSLFLQHNRIRSVEGRQLKAYLSLHVLDLSANNITEIRSTCFPHGLPLTELNLASNRISTLESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISKLTDGAFWGLARMHALHLEYNSLAEVNSGSLYGLTALHQLHLGNNSISRIHRDGWSFCQKLHELILSFNNLTRLDEESLADLSSLSILRLSHNSISHIAEGAFRGLKSLRVLDLDHNEISGTIEDTSGAFTGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGENAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLLGRTLQSFVTATCAHPEALKGQSIFSVPPESFVCDDLPKPQIITQPETITAVVGKDVRFTCSAASSSSSPMTFAWKKDNEALANADMENFAHVRAQDGEVMEYTTVLHLRRLSFEHEGRYQCVITNHFGSSYSHKAKLTVHVFPSFTKMPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIGDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVSVGETVALQCKAAGSPPPRITWLKGDRPLSLTERHHFTPGNQLLVVQNVVLEDAGRYTCEMSNALGTERAHSQLSVLPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETMVRMEGGHQANGHLESNGVCPRDAGLFPEVEAHGVICRQPKFCVGFTKEPWKVVEKADGPPGPQKTMERSGPVGCSDCSADAHAYSQEPACRLQPGDSRQPGTSSSQEPSLSEHPHSALHPSRGPLYPSNHDRTRAALKRPAAPLDGKGASSWTLARLCEPDSLDLQPSSVLTAGKPELADAASGSPDVPGEGQHLLLSNGHIPQACDSGSESTPLTGQSPGRRSTPLLFAPKS", "length": 1038, "header": "tr|A0AAA9SIZ6-1|A0AAA9TEC8_BOVIN Computationally mapped isoform of Leucine rich repeats and immunoglobulin like domains 1 OS=Bos taurus OX=9913 GN=LRIG1 PE=4 SV=1 CANONICAL=A0AAA9TEC8-1" }, "locus": { "chromosome": "22", "start_pos": 35066968, "end_pos": 34972818, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101116.2", "url": "https://www.ensembl.org/id/ENSBTAT00000101116.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085310.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085310.1" } ] } }, { "isoform_ac": "A0AAA9TEC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8/entry#A0AAA9TEC8-1", "sequence": { "sequence": "MARPVRGALGAPRRSPCLLLLWLLLLLQLEPASATAGPRAPCAAACTCAGDYLDCGGRGLAALPGDLPAWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAIPSLGSASSHIVSLFLQHNRIRSVEGRQLKAYLSLHVLDLSANNITEIRSTCFPHGLPLTELNLASNRISTLESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLRLQRNNISKLTDGAFWGLARMHALHLEYNSLAEVNSGSLYGLTALHQLHLGNNSISRIHRDGWSFCQKLHELILSFNNLTRLDEESLADLSSLSILRLSHNSISHIAEGAFRGLKSLRVLDLDHNEISGTIEDTSGAFTGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGENAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLLGRTLQSFVTATCAHPEALKGQSIFSVPPESFVCGAEVPGRCASCCLLSPWSARNLGDDILGKELPKQASCLPPEPVRQCGSSPRASRPYCRCFSRGPHAWLPYSRTEEPRPPRFSDDLPKPQIITQPETITAVVGKDVRFTCSAASSSSSPMTFAWKKDNEALANADMENFAHVRAQDGEVMEYTTVLHLRRLSFEHEGRYQCVITNHFGSSYSHKAKLTVHVFPSFTKMPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIGDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVSVGETVALQCKAAGSPPPRITWLKGDRPLSLTERHHFTPGNQLLVVQNVVLEDAGRYTCEMSNALGTERAHSQLSVLPTPGCRKDGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETMVRMEGGHQANGHLESNGVCPRDAGLFPEVEAHGVICRQPKFCVGFTKEPWKVVEKADGPPGPQKTMERSGPVGCSDCSADAHAYSQEPACRLQPGDSRQPGTSSSQEPSLSEHPHSALHPSRGPLYPSNHDRTRAALKRPAAPLDGKGASSWTLARLCEPDSLDLQPSSVLTAGKPELADAASGSPDVPGEGQHLLLSNGHIPQACDSGSESTPLTGQSPGRRSTPLLFAPKS", "length": 1172, "header": "tr|A0AAA9TEC8-1|A0AAA9TEC8_BOVIN Isoform 1 of Leucine rich repeats and immunoglobulin like domains 1 OS=Bos taurus OX=9913 GN=LRIG1 PE=4 SV=1 CANONICAL=A0AAA9TEC8-1" }, "locus": { "chromosome": "22", "start_pos": 35066968, "end_pos": 34953800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089979.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089979.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095133.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 866, "start_aa": "Thr", "end_pos": 866, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr866", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505750", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505750", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "M0RB60-1", "protein_name": "Leucine-rich repeats and immunoglobulin-like domains 1", "gene_name": "Lrig1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARPGPGVFGAPRLAPRLLLWLLLLLLLLLQGPESAVAQAGPRAPCAAACTCAGDSLDCSGRGLATLPRDMPSWTRSLNLSYNRLSEIDPAAFEDLTNLQEVYLNSNELTAVPSLGAASMHVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRVRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLKLQRNNLSKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSGLSILRLSHNAISHIAEGAFKGLKSLRVLELDHNEISGTIEDTSGAFMGLDNLSKLTLFGNKIKSVAKRAFSGLENLEHLNLGENAIRSIQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLVSRMLQAFVTATCAHPESLKGQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKVDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGSPTPRITWLKGGRPLSLTERHHFTPGNQLLVVQNVEAEDAGRYTCEMSNPLGTERAHSQLSILPTPGCRKDGSTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCLRDPSLFPEVDVHSFACRQPKLCVGYTREPWKVTEKADRTTAPHPTAHSGSAVCSDCRSDTASQPQEQAFHPQTVPRDSGQPGTSSSQELRQHDRECSPHHPYSGTVDGPHALSGGSLYPSNHDRILPSLRNKAACADGKGDSSWTLAKLQEADCIDLKPSGSPELMEDAISTEAQHLLVSNGQLPKACDSNPDSVPLKGQVTGRRRGPLLLAPKS", "length": 1096 }, "evidence": [ { "id": "A0AAA9TEC8", "url": "https://omabrowser.org/oma/group/A0AAA9TEC8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96JA1-1", "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 1", "gene_name": "LRIG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS", "length": 1093 }, "evidence": [ { "id": "A0AAA9TEC8", "url": "https://omabrowser.org/oma/group/A0AAA9TEC8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" }, { "start_pos": 767, "end_pos": 769, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TEC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEC8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 578, "end_pos": 677, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 866 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 75, "end_pos": 77 }, { "start_pos": 767, "end_pos": 769 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TGP3-1", "uniprot_ac": "A0AAA9TGP3", "uniprot_id": "A0AAA9TGP3_BOVIN", "mass": { "chemical_mass": 42135.0, "monoisotopic_mass": 42135.0 }, "refseq": {}, "gene_names": [ { "name": "SKAP1", "type": "recommended", "evidence": [ { "id": "A0AAA9TGP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ] } ], "protein_names": [ { "name": "Src kinase-associated phosphoprotein 1", "type": "recommended", "evidence": [ { "id": "A0AAA9TGP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3/entry#names_and_taxonomy" } ] }, { "name": "Src family-associated phosphoprotein 1", "type": "synonym", "evidence": [ { "id": "A0AAA9TGP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.", "evidence": [ { "database": "UniProtKB", "id": "E1B8S2", "url": "https://www.uniprot.org/uniprotkb/E1B8S2#function" }, { "database": "UniProtKB", "id": "ARBA00058951", "url": "https://www.uniprot.org/uniprotkb/ARBA00058951#function" }, { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SKAP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3", "locus": { "chromosome": "19", "start_pos": 38364932, "end_pos": 38060640, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000641", "url": "https://www.ensembl.org/id/ENSBTAG00000000641" } ] } } ], "crossref": [ { "id": "A0AAA9TGP3", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TGP3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000641", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000641", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13380", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13380", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506769", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506769", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYYQGMW", "url": "https://omabrowser.org/oma/group/NYYQGMW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B8S2", "url": "https://www.orthodb.org/?gene=E1B8S2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15129", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15129", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15129:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15129:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S6X9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6X9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8S2", "url": "https://www.uniprot.org/uniprotkb/E1B8S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8S2-1", "url": "https://www.uniprot.org/uniprotkb/E1B8S2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQAAAALPEEIRWLLEDTEDFLAEGLRNENLSAGAKDNRDHILRGLQQIKARYFWNFQPQGGDQPENYLGQDSSDDNHSGTHGPSFTSDAPFLSDYQDEGMEDIERGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGIFLIKGYSVRMAPYLRKDYKKEYCFELTSQDRRSYEFTASSPAEARDWVNQISFLLKDLSSLTIPYEEEEEKEEEEEMYDDIDGFDSSNSGSQSRPIVLPGSVGLKEAMEEKEDDIYEILPEEEHDLEEDESGTQQKGVDYASYYQGLWDCHGDQSDELSFQRGDLIRILSKEYSMYGWWVGELNSLIGIVPKEYLTTAFEVEER", "length": 364, "header": "tr|A0AAA9TGP3-1|A0AAA9TGP3_BOVIN Isoform 1 of Src kinase-associated phosphoprotein 1 OS=Bos taurus OX=9913 GN=SKAP1 PE=3 SV=2 CANONICAL=A0AAA9TGP3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3/entry#A0AAA9S6X9-1", "sequence": { "sequence": "MQAAAALPEEIRWLLEDTEDFLAEGLRNENLSAGAKDNRDHILRGLQQIKARYFWNFQPQGGDQPENYLGQDSSDDNHSGTHGPSFTSDAPFLSDYQDEGMEDIERGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGIFLIKGYSVRMAPYLRKDYKKEYCFELTSQDRRSYEFTASSPAEARDWVNQISFLLKDLSSLTIPYEEEEEEEEEEEKEEEEEMYDDIDGFDSSNSGSQSRPIVLPGSVGLKEAMEEKEDDIYEILPEEEHDLEEDESGTQQKGVDYASYYQGLWDCHGDQSDELSFQRGDLIRILSKRLIEAQFNVKRERFH", "length": 352, "header": "tr|A0AAA9S6X9-1|A0AAA9TGP3_BOVIN Computationally mapped isoform of Src kinase-associated phosphoprotein 1 OS=Bos taurus OX=9913 GN=SKAP1 PE=3 SV=1 CANONICAL=A0AAA9TGP3-1" }, "locus": { "chromosome": "19", "start_pos": 38356409, "end_pos": 38060761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124543.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124543.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079051.1" } ] } }, { "isoform_ac": "A0AAA9TGP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3/entry#A0AAA9TGP3-1", "sequence": { "sequence": "MQAAAALPEEIRWLLEDTEDFLAEGLRNENLSAGAKDNRDHILRGLQQIKARYFWNFQPQGGDQPENYLGQDSSDDNHSGTHGPSFTSDAPFLSDYQDEGMEDIERGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGIFLIKGYSVRMAPYLRKDYKKEYCFELTSQDRRSYEFTASSPAEARDWVNQISFLLKDLSSLTIPYEEEEEKEEEEEMYDDIDGFDSSNSGSQSRPIVLPGSVGLKEAMEEKEDDIYEILPEEEHDLEEDESGTQQKGVDYASYYQGLWDCHGDQSDELSFQRGDLIRILSKEYSMYGWWVGELNSLIGIVPKEYLTTAFEVEER", "length": 364, "header": "tr|A0AAA9TGP3-1|A0AAA9TGP3_BOVIN Isoform 1 of Src kinase-associated phosphoprotein 1 OS=Bos taurus OX=9913 GN=SKAP1 PE=3 SV=2 CANONICAL=A0AAA9TGP3-1" }, "locus": { "chromosome": "19", "start_pos": 38364391, "end_pos": 38060761, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090773.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090773.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097718.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097718.2" } ] } }, { "isoform_ac": "E1B8S2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3/entry#E1B8S2-1", "sequence": { "sequence": "MNVWSLMDTEDFLAEGLRNENLSAGAKDNRDHILRGLQQIKARYFWNFQPQGGDQPENYLGQDSSDDNHSGTHGPSFTSDAPFLSDYQDEGMEDIERGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGIFLIKGYSVRMAPYLRKDYKKEYCFELTSQDRRSYEFTASSPAEARDWVNQISFLLKDLSSLTIPYEEEEEEEEEEEKEEEEEMYDDIDGFDSSNSGSQSRPIVLPGSVGLKEAMEEKEDDIYEILPEEEHDLEEDESGTQQKGVDYASYYQGLWDCHGDQSDELSFQRGDLIRILSKEYSMYGWWVGELNSLIGIVPKEYLTTAFEVEER", "length": 361, "header": "tr|E1B8S2-1|E1B8S2_BOVIN Computationally mapped isoform of Src kinase-associated phosphoprotein 1 OS=Bos taurus OX=9913 GN=SKAP1 PE=3 SV=3 CANONICAL=A0AAA9TGP3-1" }, "locus": { "chromosome": "19", "start_pos": 38364391, "end_pos": 38085267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000843.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000843.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000843.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000843.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506769", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506769", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BD43-1", "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "SKAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQAAVALPEEICWLLEDAEEFLAEGLRNENLSALARDHRDHILRGFQQIKSRYFWDFQPQGGDQAENYLGQDSSDDNHSGTHGPSFTSDAAFLPDYQDEGMEDITRGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYTVRMAPYLRKDSKKECCFELTSQDRRSYEFTASNPAEARDWVDQISFLLKDLSSLTIPCEEEEEEGEEEEEEMYDDIDGFDSSNSGSQSRPIMLPGSMGLKEPTEEKEEDDIYEVLPDEELGLEEDENGTQQKGVDYANYYQGLWDCHGDQPDELSFQRGDIIRILSKEYNMYGWWVGEMNSLIGIVPKEYLTTAFEVEER", "length": 367 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZCY8-1", "protein_name": "Src kinase associated phosphoprotein 1", "gene_name": "SKAP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIPEDIQRLLEDVECFLVDGLQNENLSPKAREQRNAILFGFQQVKARYHLEFLPRGENQHDAGFGQDSSDDNQSWSLAPSMTSDVSLPSDLQDDGMEEITLRPVEDTGNILKQGYLEKRSRDHSFFGSEWQKRWCVLNRKTFHYYANEKSKQPKGTFSIEHYSARLALHLRKDSRRSCCFELVCPGKRTYEFTAPSPAEAKDWVDQIQFLLKDLSSLTIPYDEEEEELYNDVGSSDSMTTASHNTTLNQDDGMEEDDIYEVFPEEDPNAPEDSGDDGSGQHRGRSRRDYANYYQGVWDCSAEHPNELSFHRGDLIYILSKPTRCPRRHPFLPAALTTSCVHTWHLKCPKARFSSRINLTEANSAASRLQF", "length": 370 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1R4C0-1", "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "skap1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGTAVDDIRQLLRDCELFVFEILHDENLSIAARESREILQRNFVVVQKRHPQEFPHRLESNPEDSSDDNRSSSLGRSAPSDDMSVASDYQEEGGSELFEEIPLVAAQDLSNILKQGYLEKKRRDHSFFSMEWQKRWCVLNNTIFYYFGSDKDKQQKGSFYINGYSAELVPSLRKDSKKSSCFEMSAPGRRSYQFTASSPREAREWVDQINFVLKDLSSNFIPFDDDEEEEEVEEEEETYDDIERATTPPPPRPGVASAQVTTPRKTQNSHEEWKDQALPQEDEEDDEEEDIYEILPDDENSDNAEDCSERTGSSDYANYYQGLWDCEAEGPDELAFQRGDLIYILSKEYNIYGWWVGELDGAIGIVPKEFLHPAYIL", "length": 377 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3UUV5-1", "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "Skap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQAVALPEEICWLLEDTEDFLAEGLQNENLSPGAQDQRAHILRGFQQIKSRYCWDFQPQGGDLGQDGSDDNLSGTHGPPLTSEASFWSDYQDEGIEDILRGAQELDSVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYSVRMAPHLRKDSKKESCFELISQDRRSYEFTASSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEEEKEEEEMYNDVDGFDSPRSGSQCRAMALPEPTEKEEDIYEVLPDDDDLEEDTCGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSVIGIVPKDYLTTAFEMEGI", "length": 355 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4V7G1-1", "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "Skap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQAIALPEEICWLLEDAEDFLAEGLQNENLSPGAQDQRDHILRGFQQIKSRYCWDFQPQGDDLGQDGSDENLSGTHGPALASDASFWSDYQEEGIDDIIRGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVISRGLFLYYANEKSKQPKGTFLIKGYNVRMAPHLRKDSKKDSCFELTSQDRRSYEFTAFSPAEARDWVDQISFLLKDLSSLTIPFEEEEEEEEEDKEQEEMYNDIDGFDSARSGSQGRAMALPEPLDKEEDVYEVLPDEDDLEEDACGAHRRRVDYADYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSIIGIVPKDYLTTAFEMEGR", "length": 354 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86WV1-1", "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "SKAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPKEYLTTAFEVEER", "length": 359 }, "evidence": [ { "id": "A0AAA9TGP3", "url": "https://omabrowser.org/oma/group/A0AAA9TGP3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "T cell receptor complex", "id": "GO:0042101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "plasma membrane raft", "id": "GO:0044853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044853", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of adaptive immune response", "id": "GO:0002821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002821", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of integrin activation", "id": "GO:0033625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033625", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of cell-cell adhesion mediated by integrin", "id": "GO:0033634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of heterotypic cell-cell adhesion", "id": "GO:0034116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034116", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of cell-matrix adhesion", "id": "GO:0001954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001954", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "positive regulation of leukocyte cell-cell adhesion", "id": "GO:1903039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903039", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "SH2 domain binding", "id": "GO:0042169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042169", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" }, { "name": "protein phosphatase binding", "id": "GO:0019903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019903", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TGP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 216, "start_aa": "Asn", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TGP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGP3" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 299, "end_pos": 360, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", 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"MKPAGAGACAAGPLPSRFPLPFPSRALNLELARSPSPRAVERIPLPVGCHGGVSDCDGCGETALVGRATRRPPPLPGPPSPAPLPPASSPTPPSPLPLPTGHRPPIPTPVGTFGACTPQTLSSPLPSPQPPLPALFPALGAGRLVPPPPPGCGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2996, "header": "tr|A0AAA9TGB2-1|A0AAA9TGB2_BOVIN Isoform 1 of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9S8B9-1", "sequence": { "sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSTFKHGLGTASALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2851, "header": "tr|A0AAA9S8B9-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18873847, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110147.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110147.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079587.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079587.1" } ] } }, { "isoform_ac": "A0AAA9SF45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9SF45-1", "sequence": { "sequence": "MIRRTLVLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2688, "header": "tr|A0AAA9SF45-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18805435, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104233.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104233.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081064.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081064.1" } ] } }, { "isoform_ac": "A0AAA9SMQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9SMQ9-1", "sequence": { "sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2783, "header": "tr|A0AAA9SMQ9-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18873847, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104809.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104809.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085255.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085255.1" } ] } }, { "isoform_ac": "A0AAA9T5Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9T5Y2-1", "sequence": { "sequence": "MCATKNLTNMKLFPHLEFHRTKINPYLRLPQMIQNVLFSGIQDKLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2865, "header": "tr|A0AAA9T5Y2-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18888179, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111120.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111120.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094166.1" } ] } }, { "isoform_ac": "A0AAA9TBN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9TBN8-1", "sequence": { "sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2800, "header": "tr|A0AAA9TBN8-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18873847, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133187.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133187.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095425.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095425.1" } ] } }, { "isoform_ac": "A0AAA9TGB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9TGB2-1", "sequence": { "sequence": "MKPAGAGACAAGPLPSRFPLPFPSRALNLELARSPSPRAVERIPLPVGCHGGVSDCDGCGETALVGRATRRPPPLPGPPSPAPLPPASSPTPPSPLPLPTGHRPPIPTPVGTFGACTPQTLSSPLPSPQPPLPALFPALGAGRLVPPPPPGCGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2996, "header": "tr|A0AAA9TGB2-1|A0AAA9TGB2_BOVIN Isoform 1 of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18874312, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110370.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110370.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097218.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097218.1" } ] } }, { "isoform_ac": "A0AAA9U199-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#A0AAA9U199-1", "sequence": { "sequence": "MKPAGAGACAAGPLPSRFPLPFPSRALNLELARSPSPRAVERIPLPVGCHGGVSDCDGCGETALVGRATRRPPPLPGPPSPAPLPPASSPTPPSPLPLPTGHRPPIPTPVGTFGACTPQTLSSPLPSPQPPLPALFPALGAGRLVPPPPPGCGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2975, "header": "tr|A0AAA9U199-1|A0AAA9U199_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=1 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18874312, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104781.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104781.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102959.1" } ] } }, { "isoform_ac": "F1MHW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#F1MHW1-1", "sequence": { "sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPASLPCSKSAVFMQLFPHQGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2859, "header": "tr|F1MHW1-1|A0AAA9TGB2_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=4 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18873847, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015699.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015699.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015699.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015699.7" } ] } }, { "isoform_ac": "G3MXM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2/entry#G3MXM8-1", "sequence": { "sequence": "MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQMSMDHDELLRTCAPGTSLRKGKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAKMEDGQVLLTDTNTQFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVVITSSDWQHVSFEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECDAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLALVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKEHQPWSSPKASEGYLAASYPPAGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV", "length": 2694, "header": "tr|G3MXM8-1|G3MXM8_BOVIN Computationally mapped isoform of Neurofibromin OS=Bos taurus OX=9913 GN=NF1 PE=4 SV=3 CANONICAL=A0AAA9TGB2-1" }, "locus": { "chromosome": "19", "start_pos": 18873847, "end_pos": 18620094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063140.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063140.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054296.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054296.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 108, "start_aa": "Thr", "end_pos": 108, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr108", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2223, "start_aa": "Thr", "end_pos": 2223, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2223", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 91, "start_aa": "Thr", "end_pos": 91, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr91", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of developmental process", "id": "GO:0050793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050793", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGB2" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24399:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24399:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": 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ZFP14 zinc finger protein OS=Bos taurus OX=9913 GN=LOC615112 PE=3 SV=1 CANONICAL=A0AAA9TFP9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8X9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9/entry#A0AAA9S8X9-1", "sequence": { "sequence": "MAHGSVTFRDVAIDFSQEEWEFLDSAQRDLYRDVMWENYSNFISLGPSMSKPDVITLLDEGKEPWMVVREGTGKHHPDLESRYSANILSSEKDIYEIYSFQWEIMERIKSCSLQDSIFRNDWECKSKIEGQKEPQEGYFGQVKIASEKRTTYKKHNLLAEYQRVHNGEKLYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKACGKTFRQCTHLTRHQRLHTSEKLYECKECGKAFVCGPDLRIHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKDCGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYEWPLTRLKSRCRP", "length": 492, "header": "tr|A0AAA9S8X9-1|A0AAA9TFP9_BOVIN Computationally mapped isoform of ZFP14 zinc finger protein OS=Bos taurus OX=9913 GN=LOC615112 PE=3 SV=2 CANONICAL=A0AAA9TFP9-1" }, "locus": { "chromosome": "18", "start_pos": 47138374, "end_pos": 47121750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088554.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088554.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082509.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082509.2" } ] } }, { "isoform_ac": "A0AAA9TFP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9/entry#A0AAA9TFP9-1", "sequence": { "sequence": "MAHGSVTFRDVAIDFSQEEWEFLDSAQRDLYRDVMWENYSNFISLAGPSMSKPDVITLLDEGKEPWMVVREGTGKHHPDLESRYSANILSSEKDIYEIYSFQWEIMERIKSCSLQDSIFRNDWECKSKIEGQKEPQEGYFGQVKIASEKRTTYKKHNLLAEYQRVHNGEKLYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKACGKTFRQCTHLTRHQRLHTSEKLYECKECGKAFVCGPDLRIHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKDCGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHNVI", "length": 533, "header": "tr|A0AAA9TFP9-1|A0AAA9TFP9_BOVIN Isoform 1 of ZFP14 zinc finger protein OS=Bos taurus OX=9913 GN=LOC615112 PE=3 SV=1 CANONICAL=A0AAA9TFP9-1" }, "locus": { "chromosome": "18", "start_pos": 47137884, "end_pos": 47121750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106050.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106050.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095835.1" } ] } }, { "isoform_ac": "A0AAA9U209-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9/entry#A0AAA9U209-1", "sequence": { "sequence": "MAHGSVTFRDVAIDFSQEEWEFLDSAQRDLYRDVMWENYSNFISLDLESRYSANILSSEKDIYEIYSFQWEIMERIKSCSLQDSIFRNDWECKSKIEGQKEPQEGYFGQVKIASEKRTTYKKHNLLAEYQRVHNGEKLYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKACGKTFRQCTHLTRHQRLHTSEKLYECKECGKAFVCGPDLRIHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKDCGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHNVI", "length": 500, "header": "tr|A0AAA9U209-1|A0AAA9U209_BOVIN Computationally mapped isoform of ZFP14 zinc finger protein OS=Bos taurus OX=9913 GN=LOC615112 PE=3 SV=2 CANONICAL=A0AAA9TFP9-1" }, "locus": { "chromosome": "18", "start_pos": 47137884, "end_pos": 47121750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098342.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098342.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103379.2", "url": "https://www.ensembl.org/id/ENSBTAP00000103379.2" } ] } }, { "isoform_ac": "F1MJ88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9/entry#F1MJ88-1", "sequence": { "sequence": "MAHKTIYTKSCCIPNTIAEPSEPSADVLKCLQISSKGMCIIGVAGRREGIRASYRGSVTFRDVAIDFSQEEWEFLDSAQRDLYRDVMWENYSNFISLAGPSMSKPDVITLLDEGKEPWMVVREGTGKHHPDLESRYSANILSSEKDIYEIYSFQWEIMERIKSCSLQDSIFRNDWECKSKIEGQKEPQEGYFGQVKIASEKRTTYKKHNLLAEYQRVHNGEKLYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKACGKTFRQCTHLTRHQRLHTSEKLYECKECGKAFVCGPDLRIHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKDCGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHNVI", "length": 585, "header": "tr|F1MJ88-1|A0AAA9TFP9_BOVIN Computationally mapped isoform of ZFP14 zinc finger protein OS=Bos taurus OX=9913 GN=LOC615112 PE=3 SV=5 CANONICAL=A0AAA9TFP9-1" }, "locus": { "chromosome": "18", "start_pos": 47137884, "end_pos": 47121750, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131655.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131655.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081241.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081241.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615112", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615112", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFP9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 172, "end_pos": 199, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFP9" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 6, "end_pos": 78, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 38, "end_pos": 40 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFY7-1", "uniprot_ac": "A0AAA9TFY7", "uniprot_id": "A0AAA9TFY7_BOVIN", "mass": { "chemical_mass": 124517.0, "monoisotopic_mass": 124517.0 }, "refseq": {}, "gene_names": [ { "name": "UBAP2L", "type": "recommended", "evidence": [ { "id": "A0AAA9TFY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ] } ], "protein_names": [ { "name": "Ubiquitin associated protein 2 like", "type": "synonym", "evidence": [ { "id": "A0AAA9TFY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBAP2L", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7", "locus": { "chromosome": "3", "start_pos": 16252914, "end_pos": 16296273, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004271", "url": "https://www.ensembl.org/id/ENSBTAG00000004271" } ] } } ], "crossref": [ { "id": "A0AAA9TFY7", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFY7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd14277", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14277", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100125221", "url": "https://www.ncbi.nlm.nih.gov/gene/100125221", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060532", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060532", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR16308", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16308", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16308:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16308:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12478", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12478", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28540", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28540", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAX1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAX1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHA6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRN0", "url": "https://www.uniprot.org/uniprotkb/F6PRN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PRN0-1", "url": "https://www.uniprot.org/uniprotkb/F6PRN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTSVGTNRARGNWEPPQNQNQTQHKQRPQATAEQIRLAQMISDHNDADFEEKVKQLIDITGKNQDECVIALHDCNGDVNRAINVLLEGNPDTHSWEMVGKKKGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREFRGQENGLDGTKSGGPSGRGTERGRRGRGRGRGGSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGNNSGNTWNNTGHFEPDDGTSAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSSMENDSSNLDPSQAPSLAQPLVFSNSKQSAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQALAQLAAQHSQSGTTTTSSWDMGSTTQSPSLVQYDLKTPNDSTVHSPFTKRQAFTPSSTMMEVFLQEKPPAVATSTAAPPPPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQKKKASLTSKIPALAVEMPGSADISGLNLQFGALQFGSEPVLSDYESTPTTSASSSQAPSSLYTSTASESSSTISSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTRRYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQTVEGATGSAVKSDSPSTSGIPPLSETVSAASLLTTTNQHSSSLGGLSHNEEIPNTTTTQHSSTLSTQQNTLSSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHHLQQDGQLPYLQMILCCQRQQEEQVMKLNDDMLEPTPFQSPFHLHSLRELEEKRLHGHKSGYTNTNTLLSSLASRSSLVLPSSMLSFSFYPSLTLETLGYWNGKDSWSSIWSLGPQTLLCSLK", "length": 1172, "header": "tr|A0AAA9TFY7-1|A0AAA9TFY7_BOVIN Isoform 1 of Ubiquitin associated protein 2 like OS=Bos taurus OX=9913 GN=UBAP2L PE=4 SV=1 CANONICAL=A0AAA9TFY7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7/entry#A0AAA9SAU9-1", "sequence": { "sequence": 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"length": 1172, "header": "tr|A0AAA9TFY7-1|A0AAA9TFY7_BOVIN Isoform 1 of Ubiquitin associated protein 2 like OS=Bos taurus OX=9913 GN=UBAP2L PE=4 SV=1 CANONICAL=A0AAA9TFY7-1" }, "locus": { "chromosome": "3", "start_pos": 16296233, "end_pos": 16255179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094379.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094379.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095093.1" } ] } }, { "isoform_ac": "F6PRN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7/entry#F6PRN0-1", "sequence": { "sequence": 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"length": 994, "header": "tr|F6PRN0-1|F6PRN0_BOVIN Computationally mapped isoform of Ubiquitin associated protein 2 like OS=Bos taurus OX=9913 GN=UBAP2L PE=4 SV=2 CANONICAL=A0AAA9TFY7-1" }, "locus": { "chromosome": "3", "start_pos": 16296233, "end_pos": 16260704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005611.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005611.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005611.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005611.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 841, "start_aa": "Thr", "end_pos": 841, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr841", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 936, "start_aa": "Thr", "end_pos": 936, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr936", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "PcG protein complex", "id": "GO:0031519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031519", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "hematopoietic stem cell homeostasis", "id": "GO:0061484", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061484", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "stress granule assembly", "id": "GO:0034063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034063", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" }, { "name": "positive regulation of stress granule assembly", "id": "GO:0062029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062029", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFY7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 216, "end_pos": 218, "annotation": 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"annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFY7" }, { "id": "PS50030", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50030" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBA", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 89, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 841, 936 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 216, "end_pos": 218 }, { 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{ "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFM8-1", "uniprot_ac": "A0AAA9TFM8", "uniprot_id": "A0AAA9TFM8_BOVIN", "mass": { "chemical_mass": 83260.0, "monoisotopic_mass": 83260.0 }, "refseq": { "ac": "XP_002691245", "name": "coiled-coil domain-containing protein 142 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691245" }, "gene_names": [ { "name": "CCDC142", "type": "recommended", "evidence": [ { "id": "A0AAA9TFM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8" } ] }, { "name": "CCDC142", "type": "synonym", "evidence": [ { "id": "XP_002691245", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691245" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 142", "type": "synonym", "evidence": [ { "id": "A0AAA9TFM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 142 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002691245", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691245" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC142", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8", "locus": { "chromosome": "11", "start_pos": 10159251, "end_pos": 10151785, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016600", "url": "https://www.ensembl.org/id/ENSBTAG00000016600" } ] } } ], "crossref": [ { "id": "A0AAA9TFM8", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TFM8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016600", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016600", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538907", "url": "https://www.ncbi.nlm.nih.gov/gene/538907", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026700", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026700", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056901", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056901", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538907", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538907", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CCCVCNE", "url": "https://omabrowser.org/oma/group/CCCVCNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1B709", "url": "https://www.orthodb.org/?gene=E1B709", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21436", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21436", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21436:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21436:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14923", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14923", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25081", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25081", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691245", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691245", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SAY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFM8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B709", "url": "https://www.uniprot.org/uniprotkb/E1B709", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B709-1", "url": "https://www.uniprot.org/uniprotkb/E1B709-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQASRCGGLLPPLAAVPPLRAQPGGAEEEQWQKKRDVRGWPGLPVARSILCQDPRPDGAPKEQPWWVAPADAGEHSEAGAVDWGQELAAGGLIPPALRRLRAVLLRLQREREQLLQARDCALHLQAAVRFLRILSPGAPSPSHGLLLQLCRDLLQHLSGGAILRSRLLEMPHPLLLARPVGLAAQRLDATVEMRLRALGRAPATPALSSQLADLLLALPAYHQLQGKVFSQVPASARPYPPGRVLRLLTGERGCQVADWLDEALRGSGLRDQLLRRCQEERELLPGLLGLLGGVTGSASSELGLGGAGALWSQYWTLLWAACAQSLDLSLGPWRDSRAAAQQLSQALGQASLPQECEKELASLCRNLTHQSLIWSWDQGFCQVLGSASGNQSSLPSSSCTTKLLQQLFPPLLDALREPRSGLLLCGPPGPAPLALGLCTLQTTLLWFWSRTQQHLAAWAPGSFLLLIQKDLPPLLQEAEALSHLASEESLALDVEQQLGLEIRKLTVQIQLLPEESLSLFFQECHKQATQDFELHMPRGRYWRHRLCSELPSIPSEYAGLVVRRVLEPVLQGLHGLPPQAQAPALSQALTAILGAWLDHILSHGIRFSLQGALQLRQDFGVVRDLLEEEQWGLSPELRQTLFMLSIFQRLDGALLCLLQQPLPKTQVHRRLPRCCACNEVQTMELPSSSLNSLESLEPPLRPGVFPTQTAQLLSTLWGGGPSPDAYLVGNQQAWLALRQHQHPRWHLSFLSCLGTSSES", "length": 760, "header": "tr|A0AAA9TFM8-1|A0AAA9TFM8_BOVIN Isoform 1 of Coiled-coil domain containing 142 OS=Bos taurus OX=9913 GN=CCDC142 PE=4 SV=1 CANONICAL=A0AAA9TFM8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8/entry#A0AAA9SAY9-1", "sequence": { "sequence": "MAQASRCGGLLPPLAAVPPLRAQPGGAEEEQWQKKRDVRGWPGLPVARSILCQDPRPDGAPKEQPWWVAPADAGEHSEAGAVDWGQELAAGGLIPPALRRLRAVLLRLQREREQLLQARDCALHLQAAVRFLRILSPGAPSPSHGLLLQLCRDLLQHLSGGAILRSRLLEMPHPLLLARPVGLAAQRLDATVEMRLRALGRAPATPALSSQLADLLLALPAYHQLQGKVFSQVPASARPYPPGRVLRLLTGERGCQVADWLDEALRGSGLRDQLLRRCQEERELLPGLLGLLGGVTGSASSELGLGGAGALWSQYWTLLWAACAQSLDLSLGPWRDSRAAAQQLSQALGQGFCQVLGSASGNQSSLPSSSCTTKLLQQLFPPLLDALREPRSGLLLCGPPGPAPLALGLCTLQTTLLWFWSRTQQHLAAWAPGSFLLLIQKDLPPLLQEAEALSHLASEESLALDVEQQLGLEIRKLTVQIQLLPEESLSLFFQECHKQATQDFELHMPRGRYWRHRLCSELPSIPSEYAGLVVRRVLEPVLQGLHGLPPQAQAPALSQALTAILGAWLDHILSHGIRFSLQGALQLRQDFGVVRDLLEEEQWGLSPELRQTLFMLSIFQRLDGALLCLLQQPLPKTQVHRRLPRCCACNEVQTMELPSSSLNSLESLEPPLRPGVFPTQTAQLLSTLWGGGPSPDAYLVGNQQAWLALRQHQHPRWHLSFLSCLGTSSES", "length": 731, "header": "tr|A0AAA9SAY9-1|A0AAA9TFM8_BOVIN Computationally mapped isoform of Coiled-coil domain containing 142 OS=Bos taurus OX=9913 GN=CCDC142 PE=4 SV=1 CANONICAL=A0AAA9TFM8-1" }, "locus": { "chromosome": "11", "start_pos": 10158172, "end_pos": 10151984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131962.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131962.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081068.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081068.1" } ] } }, { "isoform_ac": "A0AAA9TFM8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8/entry#A0AAA9TFM8-1", "sequence": { "sequence": "MAQASRCGGLLPPLAAVPPLRAQPGGAEEEQWQKKRDVRGWPGLPVARSILCQDPRPDGAPKEQPWWVAPADAGEHSEAGAVDWGQELAAGGLIPPALRRLRAVLLRLQREREQLLQARDCALHLQAAVRFLRILSPGAPSPSHGLLLQLCRDLLQHLSGGAILRSRLLEMPHPLLLARPVGLAAQRLDATVEMRLRALGRAPATPALSSQLADLLLALPAYHQLQGKVFSQVPASARPYPPGRVLRLLTGERGCQVADWLDEALRGSGLRDQLLRRCQEERELLPGLLGLLGGVTGSASSELGLGGAGALWSQYWTLLWAACAQSLDLSLGPWRDSRAAAQQLSQALGQASLPQECEKELASLCRNLTHQSLIWSWDQGFCQVLGSASGNQSSLPSSSCTTKLLQQLFPPLLDALREPRSGLLLCGPPGPAPLALGLCTLQTTLLWFWSRTQQHLAAWAPGSFLLLIQKDLPPLLQEAEALSHLASEESLALDVEQQLGLEIRKLTVQIQLLPEESLSLFFQECHKQATQDFELHMPRGRYWRHRLCSELPSIPSEYAGLVVRRVLEPVLQGLHGLPPQAQAPALSQALTAILGAWLDHILSHGIRFSLQGALQLRQDFGVVRDLLEEEQWGLSPELRQTLFMLSIFQRLDGALLCLLQQPLPKTQVHRRLPRCCACNEVQTMELPSSSLNSLESLEPPLRPGVFPTQTAQLLSTLWGGGPSPDAYLVGNQQAWLALRQHQHPRWHLSFLSCLGTSSES", "length": 760, "header": "tr|A0AAA9TFM8-1|A0AAA9TFM8_BOVIN Isoform 1 of Coiled-coil domain containing 142 OS=Bos taurus OX=9913 GN=CCDC142 PE=4 SV=1 CANONICAL=A0AAA9TFM8-1" }, "locus": { "chromosome": "11", "start_pos": 10158172, "end_pos": 10151984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109135.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109135.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095809.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095809.1" } ] } }, { "isoform_ac": "E1B709-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8/entry#E1B709-1", "sequence": { "sequence": "MAQASRCGGLLPPLAAVPPLRAQPGGAEEEQWQKKRDVRGWPGLPVARSILCQDPRPDGAPKEQPWWVAPADAGEHSEAGAVDWGQELAAGGLIPPALRRLRAVLLRLQREREQLLQARDCALHLQAAVRFLRILSPGAPSPSHGLLLQLCRDLLQHLSGGAILRSRLLEMPHPLLLARPVGLAAQRLDATVEMRLRALGRAPATPALSSQLADLLLALPAYHQLQGKVFSQVPASARPYPPGRVLRLLTGERGCQVADWLDEALRGSGLRDQLLRRCQEERELLPGLLGLLGGVTGSASSELGLGGAGALWSQYWTLLWAACAQSLDLSLGPWRDSRAAAQQLSQALGQASLPQECEKELASLCRNLTHQSLIWSWDQGFCQVLGSASGNQSSLPSSSCTTKLLQQLFPPLLDALREPRSGLLLCGPPGPAPLALGLCTLQTTLLWFWSRTQQHLAAWAPGSFLLLIQKDLPPLLQEAEALSHLASEESLALDVEQQLGLEIRKLTVQIQLLPEESLSLFFQECHKQATQDFELHMPRGRYWRHRLCSELPSIPSEYAGLVVRRVLEPVLQGLHGLPPQAQAPALSQALTAILGAWLDHILSHGIRFSLQGALQLRQDFGVVRDLLEEEQWGLSPELRQTLFMLSIFQRLDGALLCLLQQPLPKTQVHRRLPRCCACNEVQTMELPSSSLNSLESLEPPLRPGVFPTQTAQLLSTLWGGGPSPDAYLGGGLGTSTANTGGESAPSGGP", "length": 749, "header": "tr|E1B709-1|E1B709_BOVIN Computationally mapped isoform of Coiled-coil domain containing 142 OS=Bos taurus OX=9913 GN=CCDC142 PE=4 SV=2 CANONICAL=A0AAA9TFM8-1" }, "locus": { "chromosome": "11", "start_pos": 10159143, "end_pos": 10151984, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022083.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022083.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022083.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022083.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 205, "start_aa": "Thr", "end_pos": 205, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr205", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538907", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538907", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2KB94-1", "protein_name": "Coiled-coil domain containing 142", "gene_name": "Ccdc142", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARASRSSGLLPPITNVPPSWAQPLGDGEERGKGKRGGLELLAAMSAPCPDSGRQPWAPESASGPMPFALQRLRAELLRLHREREQLLRARDCARHLQAVVRLLRSGSSAGSFSLQQLHGDLQMCPSRRAAQRLGFPGSRETLLLARPVGLAAQHLDANIEMQLRTLGRAPASLGLTSQLAELLLALPFYHTLQGQSLSFVPGAARPFPAARVLHLLAAERGCQVADRLAEALGRSGLQDQLRRQCDQERELLPGLLGLIGGVASRDSSGLRLGGPGALWSQYWTMLWAACAQSLDLRVGPWGDPKAVAQQLSQALCQASLPQECEKELLSLCHSLFHRSLVCSWDQGFCQALGSAVGGQSSPASPSTAELLQRLFPPLLDILRQPRPELSLCQPAGPTPVALGLCTLQTTLLWFLGKAQQHLAAWAPGPFLLLIQKDLPPLLHAVEALSSLASEAAFSLEVEQQLGLEIQKLTARMQLLPKESLSLFFQECHKQATQGFKLHMPRGGYWRLRLCPEHPSDPSEYARVVVYTVLEPVLQGLRGLPPEAQAPALSQALTATLGAWLDHILTHGIRFSLQGALQLKQDFGVVREVLEQEQWGLSPELRQTLLSLSIFQQLDGALLCLLQQPLPKNPVQRRPHRCCFCNEVQTIELPTSSLNSLESLAPPLRPGVSPAQNTHLLSTLGGGGRGGGGGGPSPEAYLAGNQQAWLALRLHQHPRWHLPFFSCLGTSPEP", "length": 734 }, "evidence": [ { "id": "A0AAA9TFM8", "url": "https://omabrowser.org/oma/group/A0AAA9TFM8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q17RM4-1", "protein_name": "Coiled-coil domain-containing protein 142", "gene_name": "CCDC142", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQASRSGSLPPLVIVPPLRAQPGGTGEEQWERSRTGGLRWEVHCWPSGTSGGTPWWPTPADVSEDYEADAAAWRRGPAGGGPIPPALQRLRAVLLRLHREREQLLQARDCAYHLQSAVRLMKTLSPGSPSGGPSPLPQWCRDLQLHPSQGAVLRIGPGETLEPLLLARPIGLAAQCLEAVIEMQLRALGREPASPGLSSQLAELLFALPAYHTLQRKALSHVPGAARPFPTSRVLRLLTGERGCQVASRLDEALQGSALRDQLRRRCQEEGDLLPGLLGLVGGVAGSASCGLGLGGAGALWSQYWTLLWAACAQSLDLNLGPWRDPRATAQQLSQALGQASLPQECEKELASLCHRLLHQSLIWSWDQGFCQALGSALGGQSSLPTSSGTAELLQQLFPPLLDALREPRLRRIFCQPADPAPVALGLCTLQTTLLWFLGRAQQYLAAWDPASFLLLIQKDLPPLLHEAEALYSLASEESLALEVEQQLGLEIQKLTAQIQLLPEESLSVFSQECHKQAMQGFKLYMPRGRYWRLRLCPEPPSAPSEYAGLVVRTVLEPVLQGLQGLPPQAQAPALGQALTAIVGAWLDHILTHGIRFSLQGALQLKQDFGVVRELLEEEQWSLSPDLRQTLLMLSIFQQLDGALLCLLQQPLPKSQVHRRPPCCCACQEVQTTKLPSSCLNSLESLEPPLQPGTSPAQTGQLQSTLGGRGPSPEGYLVGNQQAWLALRQHQRPRWHLPFFSCLGTSPES", "length": 750 }, "evidence": [ { "id": "A0AAA9TFM8", "url": "https://omabrowser.org/oma/group/A0AAA9TFM8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CAI1-1", "protein_name": "Coiled-coil domain-containing protein 142", "gene_name": "Ccdc142", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARASSSSGPLPPLANVPSSWAQPVGAGEERDEGRRGGLGLLAAVSVPCPDFSRQPWAPASASGPMPFALQRLRATLLRLHREREQLLRARDCARHLQAVVRLLRSGSSAGSLSLQQLHGDLQLCPSRGAALRLGFPGSRETLLLTRPVGLAAQHLEAAIEMQLRSLGRTPASLGLTSQLAELLLALPFYHTLQGHSLNFVPGAARPFPAARVLQLLAAERGCQVADKLAEARGGSGLQEQLRRQCEQERELLPGLLGLVGGVASTDSSGLRLGGPGALWSQYWTLLWAACAKCLDLRVGPWEDPRAMAQELSQALCQAPLPQECEKELLSLCHSLFHQSVICSWDQGFCQALGSALGGQSSPASLSPTSELLQRLFPPLLDSLRQPRPELRLCPPAGPTPVALGLCTLQTTLLWFVGRAQQHLAAWDPGSFLLLLQKDLPPLLSAVEALSSLASEAALTLEVEQQLGLEIHNLTEKMQLLPKESLGLFVQECHKQATQGFKLHMPRGRYWRLRLCPEPPSDPSEYARIVVYSVLEPVLQGLQGLPPEAQAPALGQALTATLGAWLDHILTHGIRFSLQGALQLKQDFGVVREVLEQEQWGLSQELRQTLLSLSIFQQLDGALLCLLQQPLPKNPVHRRPPRCCLCYEVQTTELPTSSLNSLENLAPPLRLGVSPAQNTHLLSTLGGGGRGGGGGGGPGPSPEAYLVGNQQAWLALRLHQHPRWHLPFFSCLRTSPEP", "length": 738 }, "evidence": [ { "id": "A0AAA9TFM8", "url": "https://omabrowser.org/oma/group/A0AAA9TFM8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": {}, "pro_annotation": [], "site_annotation": [ { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8" }, { "id": "PF25081", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25081" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CC142 N-terminal", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 293, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TFM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFM8" }, { "id": "PF14923", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coiled-coil protein 142 C-terminal", "eco_id": "ECO_0000259", "start_pos": 319, "end_pos": 736, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 205 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 367, "end_pos": 369 }, { "start_pos": 391, "end_pos": 393 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TFE9-1", "uniprot_ac": "A0AAA9TFE9", "uniprot_id": "A0AAA9TFE9_BOVIN", "mass": { "chemical_mass": 56850.0, "monoisotopic_mass": 56850.0 }, "refseq": { "ac": "XP_015314768", "name": "serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314768" }, "gene_names": [ { "name": "PPP2R3C", "type": "recommended", "evidence": [ { "id": "A0AAA9TFE9", "database": 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phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9#function" }, { "database": "UniProtKB", "id": "ARBA00057358", "url": "https://www.uniprot.org/uniprotkb/ARBA00057358#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP2R3C", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9", "locus": { "chromosome": "21", "start_pos": 45369633, "end_pos": 45395978, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009681", "url": "https://www.ensembl.org/id/ENSBTAG00000009681" } ] } } ], 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Classification" ] }, { "id": "PTHR12085", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12085", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12085:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12085:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17958", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17958", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015314768", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015314768", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFE9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTY7", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDWKEILRRRLATPSTSPHSEFGRSRLLRDPGPKHRELGGRWMGRSSTFEKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSTDLDDT", "length": 483, "header": "tr|A0AAA9TFE9-1|A0AAA9TFE9_BOVIN Isoform 1 of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Bos taurus OX=9913 GN=PPP2R3C PE=4 SV=1 CANONICAL=A0AAA9TFE9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9/entry#A0AAA9SCQ5-1", "sequence": { "sequence": "MDWKEILRRRLATPSTSPHKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKGDSFSFCFNSLSENKEFGSLLL", "length": 189, "header": "tr|A0AAA9SCQ5-1|A0AAA9TFE9_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Bos taurus OX=9913 GN=PPP2R3C PE=4 SV=1 CANONICAL=A0AAA9TFE9-1" }, "locus": { "chromosome": "21", "start_pos": 45395326, "end_pos": 45385341, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092341.1", "url": 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CANONICAL=A0AAA9TFE9-1" }, "locus": { "chromosome": "21", "start_pos": 45395326, "end_pos": 45369750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095701.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095701.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096855.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096855.1" } ] } }, { "isoform_ac": "A0AAF6YTY7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9/entry#A0AAF6YTY7-1", "sequence": { "sequence": "MDWKEILRRRLATPSTSPHKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGPKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDNENSTDLDDT", "length": 433, "header": "tr|A0AAF6YTY7-1|A0AAF6YTY7_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Bos taurus OX=9913 GN=PPP2R3C PE=4 SV=1 CANONICAL=A0AAA9TFE9-1" }, "locus": { "chromosome": "21", "start_pos": 45395326, "end_pos": 45369750, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012770.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012770.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012770.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012770.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of dephosphorylation", "id": "GO:0035303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035303", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFE9", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9TFE9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFE9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TFE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE9" }, { "id": "PF17958", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17958" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PP2A regulatory subunit B'' EF-hand", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 288, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 476, "end_pos": 478 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEE5-1", "uniprot_ac": "A0AAA9TEE5", "uniprot_id": "A0AAA9TEE5_BOVIN", "mass": { "chemical_mass": 119589.0, "monoisotopic_mass": 119589.0 }, "refseq": {}, "gene_names": [ { "name": "DENND1A", "type": "recommended", "evidence": [ { "id": "A0AAA9TEE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ] } ], "protein_names": [ { "name": "DENN domain containing 1A", "type": "synonym", "evidence": [ { "id": "A0AAA9TEE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DENND1A", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5", "locus": { "chromosome": "11", "start_pos": 94527961, "end_pos": 95058758, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003610", "url": "https://www.ensembl.org/id/ENSBTAG00000003610" } ] } } ], "crossref": [ { "id": "A0AAA9TEE5", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TEE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003610", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003610", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514134", "url": "https://www.ncbi.nlm.nih.gov/gene/514134", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005112", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005113", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005113", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MGE0", "url": "https://www.orthodb.org/?gene=A0A3Q1MGE0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MME2", "url": "https://www.orthodb.org/?gene=F1MME2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13196:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13196:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03455", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03455", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MGE0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGE0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SES9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SES9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MME2", "url": "https://www.uniprot.org/uniprotkb/F1MME2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MME2-1", "url": "https://www.uniprot.org/uniprotkb/F1MME2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRIKQNPETTFEVYVEVACPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKGQESQWNELLETLYKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMFWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRSMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKSRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMSEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCAPTTEEQLPKTVPSPLVEAKDPKFREDRRPITVHFGQVRPPRPHVVKRPKSNITVEARRTSVSSPDQPQPYRTLKESDSAGDEAESPEQRAREPVGPTPAPHDRAASINLLEDVFSNLDMEVPLQQLGQAKSLEDLRTPKDLREQPGTFDYQRLDLGRSDRSRGTPGALKLAHPHSRLWSLGQDDMAIPSKPPAACPEKPSALLGNSLASPCRPQNQNGLLNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPTARPAKLQAPGIALGDFLEQLPAERERRAALSSTPFPGLLSSAAPQDPTELLQPLSLAPGAAGSSSDALLALLDPLNTTWSGSSLPPGPTAPNVATPFTPQFSFPPMGTPTPFPQPSLNPFVPPLPATLPTMPLVSAPAGPFGAPPASLGPAFAPSLLLSNSGFCAPHRSQPNLSALSMPNLFGQVPMGTHSLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGEPPLLPARPPQGLEPALQPSAPREARDPFEDLLRKTKQDVSSAPAPGSVEQLRKQWETFDCSPARTPHLDGHECWRYTSSSAREARGLEFEVRNPPPPPLPSWRIYLARHFQTLSSNMHTLSLLSLHPNPSTSVFLTWLGSGG", "length": 1089, "header": "tr|A0AAA9TEE5-1|A0AAA9TEE5_BOVIN Isoform 1 of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=1 CANONICAL=A0AAA9TEE5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#A0A3Q1MGE0-1", "sequence": { "sequence": "MGSRIKQNPETTFEVYVEVACPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKGQESQWNELLETLYKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMFWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRSMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKSRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMSEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCAPTTEEQLPKTVPSPLVEAKDPKFREDRRPITVHFGQPQRLRPTRPLPPKIQRSRPVRPPRPHVVKRPKSNITVEARRTSVSSPDHLVRPLRHYAVFLSEDSSDDECQREEGPSSGFTESFFFSTPFEWPQPYRTLKESDSAGDEAESPEQRAREPVGPTPAPHDRAASINLLEDVFSNLDMEVPLQQLGQAKSLEDLRTPKDLREQPGTFDYQRLDLGRSDRSRGTPGALKLAHPHSRLWSLGQDDMAIPSKPPAACPEKPSALLGNSLASPCRPQNQNGLLNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPTARPAKLQAPGIALGDFLEQLPAERERRAALSSTPFPGLLSSAAPQDPTELLQPLSLAPGAAGSSSDALLALLDPLNTTWSGSSLPPGPTAPNVATPFTPQFSFPPMGTPTPFPQPSLNPFVPPLPATLPTMPLVSAPAGPFGAPPASLGPAFAPSLLLSNSGFCAPHRSQPNLSALSMPNLFGQVPMGTHSLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGEPPLLPARPPQGLEPALQPSAPREARDPFEDLLRKTKQDVSSAPAPGSVEQLRKQWETFE", "length": 1068, "header": "tr|A0A3Q1MGE0-1|A0A3Q1MGE0_BOVIN Computationally mapped isoform of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=2 CANONICAL=A0AAA9TEE5-1" }, "locus": { "chromosome": "11", "start_pos": 95058514, "end_pos": 94529577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086161.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086161.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069607.2" } ] } }, { "isoform_ac": "A0AAA9SES9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#A0AAA9SES9-1", "sequence": { "sequence": "MLKWPVLGQVALFQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKGQESQWNELLETLYKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMFWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRSMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKSRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMSEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCAPTTEEQLPKTVPSPLVEAKDPKFREDRRPITVHFGQVRPPRPHVVKRPKSNITVEARRTSVSSPDQPQPYRTLKESDSAGDEAESPEQRAREPVGPTPAPHDRAASINLLEDVFSNLDMEVPLQQLGQAKSLEDLRTPKDLREQPGTFDYQRLDLGRSDRSRGTPGALKLAHPHSRLWSLGQDDMAIPSKPPAACPEKPSALLGNSLASPCRPQNQNGLLNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPTARPAKLQAPGIALGDFLEQLPAERERRAALSSTPFPGLLSSAAPQDPTELLQPLSLAPGAAGSSSDALLALLDPLNTTWSGSSLPPGPTAPNVATPFTPQFSFPPMGTPTPFPQPSLNPFVPPLPATLPTMPLVSAPAGPFGAPPASLGPAFAPSLLLSNSGFCAPHRSQPNLSALSMPNLFGQVPMGTHSLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGEPPLLPARPPQGLEPALQPSAPREARDPFEDLLRKTKQDVSSAPAPGSVEQLRKQWETFE", "length": 976, "header": "tr|A0AAA9SES9-1|A0AAA9TEE5_BOVIN Computationally mapped isoform of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=1 CANONICAL=A0AAA9TEE5-1" }, "locus": { "chromosome": "11", "start_pos": 95012643, "end_pos": 94529577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111305.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111305.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084651.1" } ] } }, { "isoform_ac": "A0AAA9SZC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#A0AAA9SZC8-1", "sequence": { "sequence": "MGSRIKQNPETTFEVYVEVACPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKGQESQWNELLETLYKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMFWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRSMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKSRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMSEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCAPTTEEQLPKTVPSPLVEAKDPKFREDRRPITVHFGQVRPPRPHVVKRPKSNITVEARRTSVSSPDQNTPTLASLPKSIAHVAKSPIRAWTSPPHV", "length": 555, "header": "tr|A0AAA9SZC8-1|A0AAA9TEE5_BOVIN Computationally mapped isoform of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=1 CANONICAL=A0AAA9TEE5-1" }, "locus": { "chromosome": "11", "start_pos": 95058514, "end_pos": 94547500, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118264.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118264.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091810.1" } ] } }, { "isoform_ac": "A0AAA9T7N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#A0AAA9T7N6-1", "sequence": { "sequence": "MLKWPVLGQVALFQILRCRGNSRRTTVTSYLPWFEVFYKLLNILADYTTKGQESQWNELLETLYKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMFWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRSMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKSRLKKVSTTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEINMSEYAGSDKLYHQWLSTVRKGSGAILNTVKTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDITENGCAPTTEEQLPKTVPSPLVEAKDPKFREDRRPITVHFGQPQRLRPTRPLPPKIQRSRPVRPPRPHVVKRPKSNITVEARRTSVSSPDQPQPYRTLKESDSAGDEAESPEQRAREPVGPTPAPHDRAASINLLEDVFSNLDMEVPLQQLGQAKSLEDLRTPKDLREQPGTFDYQRLDLGRSDRSRGTPGALKLAHPHSRLWSLGQDDMAIPSKPPAACPEKPSALLGNSLASPCRPQNQNGLLNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPTARPAKLQAPGIALGDFLEQLPAERERRAALSSTPFPGLLSSAAPQDPTELLQPLSLAPGAAGSSSDALLALLDPLNTTWSGSSLPPGPTAPNVATPFTPQFSFPPMGTPTPFPQPSLNPFVPPLPATLPTMPLVSAPAGPFGAPPASLGPAFAPSLLLSNSGFCAPHRSQPNLSALSMPNLFGQVPMGTHSLQPLGPPAVAPSRIRTLPLARSSARAAEAKQGLALRPGEPPLLPARPPQGLEPALQPSAPREARDPFEDLLRKTKQDVSSAPAPGSVEQLRKQWETFE", "length": 953, "header": "tr|A0AAA9T7N6-1|A0AAA9TEE5_BOVIN Computationally mapped isoform of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=1 CANONICAL=A0AAA9TEE5-1" }, "locus": { "chromosome": "11", "start_pos": 95012643, "end_pos": 94529577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108681.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108681.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091863.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091863.1" } ] } }, { "isoform_ac": "A0AAA9TEE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5/entry#A0AAA9TEE5-1", "sequence": { "sequence": 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"tr|F1MME2-1|A0AAA9TEE5_BOVIN Computationally mapped isoform of DENN domain containing 1A OS=Bos taurus OX=9913 GN=DENND1A PE=4 SV=3 CANONICAL=A0AAA9TEE5-1" }, "locus": { "chromosome": "11", "start_pos": 94884963, "end_pos": 94529577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061512.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061512.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053496.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053496.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 557, "start_aa": "Thr", "end_pos": 557, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr557", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 690, "start_aa": "Thr", "end_pos": 690, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr690", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 806, "start_aa": "Thr", "end_pos": 806, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr806", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8876198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "resource": "Reactome", "description": "RAB GEFs exchange GTP for GDP on RABs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "clathrin-coated vesicle membrane", "id": "GO:0030665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030665", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEE5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TEP0-1", "uniprot_ac": "A0AAA9TEP0", "uniprot_id": "A0AAA9TEP0_BOVIN", "mass": { "chemical_mass": 27597.0, "monoisotopic_mass": 27597.0 }, "refseq": { "ac": "XP_005205144", "name": "V-set and transmembrane domain-containing protein 2A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205144" }, "gene_names": [ { "name": "VSTM2A", "type": "recommended", "evidence": [ { "id": "A0AAA9TEP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEP0" } ] }, { "name": "VSTM2A", "type": "synonym", "evidence": [ { "id": "XP_005205144", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205144" } ] } ], "protein_names": [ { "name": "V-set and transmembrane domain-containing protein 2A", "type": "recommended", "evidence": [ { "id": "A0AAA9TEP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEP0/entry#names_and_taxonomy" } ] }, { "name": "V-set and transmembrane domain-containing protein 2A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005205144", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005205144" } ] } ], "function": [ { "annotation": "Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. 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"Protein Classification", "Other" ] }, { "id": "PF06367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06371", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06371", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059742619", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742619", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SF63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B718", "url": "https://www.uniprot.org/uniprotkb/E1B718", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B718-1", "url": "https://www.uniprot.org/uniprotkb/E1B718-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNLESAEGGPGEPSSVSLLPPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEALESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESVKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGSEALARVGSAELNEGMPHSDLDLLTLAPPAEEALPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELTAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 1028, "header": "tr|A0AAA9TGU4-1|A0AAA9TGU4_BOVIN Isoform 1 of Formin like 3 OS=Bos taurus OX=9913 GN=FMNL3 PE=3 SV=1 CANONICAL=A0AAA9TGU4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SF63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4/entry#A0AAA9SF63-1", "sequence": { "sequence": "MGNLESAEGGPGEPSSVSLLPPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEALESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESVKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGSEALARVGSAELNEGMPHSDLDLLTLAPPAEEALPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELTAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITGLHHQPLVVRHPARSAAPPAGPPRAPGPH", "length": 1027, "header": "tr|A0AAA9SF63-1|A0AAA9TGU4_BOVIN Computationally mapped isoform of Formin like 3 OS=Bos taurus OX=9913 GN=FMNL3 PE=3 SV=1 CANONICAL=A0AAA9TGU4-1" }, "locus": { "chromosome": "5", "start_pos": 30201507, "end_pos": 30151294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121497.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121497.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084017.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084017.1" } ] } }, { "isoform_ac": "A0AAA9TGU4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4/entry#A0AAA9TGU4-1", "sequence": { "sequence": "MGNLESAEGGPGEPSSVSLLPPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEALESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESVKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGSEALARVGSAELNEGMPHSDLDLLTLAPPAEEALPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELTAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 1028, "header": "tr|A0AAA9TGU4-1|A0AAA9TGU4_BOVIN Isoform 1 of Formin like 3 OS=Bos taurus OX=9913 GN=FMNL3 PE=3 SV=1 CANONICAL=A0AAA9TGU4-1" }, "locus": { "chromosome": "5", "start_pos": 30200721, "end_pos": 30151294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113260.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113260.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096086.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096086.1" } ] } }, { "isoform_ac": "E1B718-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4/entry#E1B718-1", "sequence": { "sequence": "MGNLESAEGGPGEPSSVSLLPPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESVKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGSEALARVGSAELNEGMPHSDLDLLTLAPPAEEALPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELTAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 977, "header": "tr|E1B718-1|E1B718_BOVIN Computationally mapped isoform of Formin like 3 OS=Bos taurus OX=9913 GN=FMNL3 PE=3 SV=3 CANONICAL=A0AAA9TGU4-1" }, "locus": { "chromosome": "5", "start_pos": 30200721, "end_pos": 30151294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022075.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022075.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022075.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022075.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540105", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540105", "resource": "KEGG Pathway" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6ART4-1", "protein_name": "Formin-like 3", "gene_name": "Fmnl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNLESTDGGPGEPPSVPLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPNVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFLVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARSLESMGGSEALARVGPTELTEGSTPSDLDLLAPAPPAEETLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRTAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGAIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 1029 }, "evidence": [ { "id": "A0AAA9TGU4", "url": "https://omabrowser.org/oma/group/A0AAA9TGU4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6NXC0-1", "protein_name": "Formin-like protein 3", "gene_name": "fmnl3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNIESVDGQSEMKHHIMPLKVPMPDPTELEERFAIVLNSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLRGYLDPKVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENRGLDILVEYLSFAQCAVMLDFEGLENGEDFSLDKAKSWSRSIEDLHQNGCNTLVRSARQSVLRYGSTSNSKTIKNSRLVSQKDDVHVCIMCLRAIMNYQYGFNLVMSHAHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCKEKHRFEKLMEYFRSEDGNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLDDFLEKSKHTESDKLSVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHLSHVTEKLLDVENETMTKVADLEKQLLHKDKELAVIKETYESASTQVHTLRRMIQEKDAAFQRHNNIEKQLLELEQQGTIRLRKQPDGDIAIETLGAGAVAGTPLTDLRSLTVGMSTIGGLGGTSAVPVEAVAPPPPPPPPPPPPPPAPPLPSEVESIPIPPPPPPPLPGPSPSVILSVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFNEIDDDRVLEELDLEKFEELFKTKAQGPVVDLSCSKSKVSQKVINKVQLLDANRSKNLAITLRKANKTTEEICKAIQTFDLKALPVDFVECLMRFLPTEAESKLLRQYERERRPLDQLAEEDRFMLLFSKIERLTQRMSIITFVGNFNDNVNMLTPQLNAIIAASASVKSSPKLKKILEIILALGNYMNSSKRGSVYGFKLQSLDLLLDTKSTDRKMTLLHYIALVVKEKYPELANFYNELHFVDKAAAVSLENVLLDVKELGKGMDLVRRECSLHDHAVLKGFAQTSDTQLDKLAKDAKTAEEAFNNVVLYFGESPKTTPPSVFFPVFVRFIRAYKEAVEENEQRKKQEEAMREKLLAQEAKQHDPKVQAQKKRHQQQELIAELRRRQAKDHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDANLFDESIC", "length": 1047 }, "evidence": [ { "id": "A0AAA9TGU4", "url": "https://omabrowser.org/oma/group/A0AAA9TGU4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6ZPF4-1", "protein_name": "Formin-like protein 3", "gene_name": "Fmnl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNLESTDGGPGEPPSVPLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPNVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGGEALARVGPTELTEGIPPSDLDLLAPAPPTEETLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQINGTVFSELDDEKILEDLDLDRFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 1028 }, "evidence": [ { "id": "A0AAA9TGU4", "url": "https://omabrowser.org/oma/group/A0AAA9TGU4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVF7-1", "protein_name": "Formin-like protein 3", "gene_name": "FMNL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC", "length": 1028 }, "evidence": [ { "id": "A0AAA9TGU4", "url": "https://omabrowser.org/oma/group/A0AAA9TGU4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "GTPase activating protein binding", "id": "GO:0032794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "regulation of cell morphogenesis", "id": "GO:0022604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton organization", "id": "GO:0030866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TGU4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 778, "end_pos": 780, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TGU4", "database": "UniProtKB", "url": 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adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR1#function" }, { "database": "UniProtKB", "id": "RU364108", "url": "https://www.uniprot.org/uniprotkb/RU364108#function" }, { "database": "UniProtKB", "id": "ARBA00002269", "url": "https://www.uniprot.org/uniprotkb/ARBA00002269#function" }, { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44#function" }, { "database": "UniProtKB", "id": "A0AAF6Z2A6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2A6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NMD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44", "locus": { "chromosome": "1", "start_pos": 106135036, "end_pos": 106187628, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016228", "url": "https://www.ensembl.org/id/ENSBTAG00000016228" } ] } } ], "crossref": [ { "id": "A0AAA9TG44", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TG44", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR007064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048898", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048898", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12746", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12746", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12746:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12746:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04981", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04981", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SJR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TG44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2A6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2A6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6Z2A6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z2A6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDYLSSLHKTWEAFSDHKVYRKMEYMTDPVKHTPGHILCCDCGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWVQCALESRDLLALCLKKIKAPLSKVRLVDASFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQPQMCGDCHRVEAKDFWKAVVQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPTRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSVIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRSAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLVNCNLNDEHVNKMKSDRVPDVVLIKKSYDRTRRQRRRNWKLKELARDRENTDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSTIPVESDTDDEGAPRISLAEMLEDLHISQDATGGEGESMMT", "length": 526, "header": "tr|A0AAA9TG44-1|A0AAA9TG44_BOVIN Isoform 1 of 60S ribosomal export protein NMD3 OS=Bos taurus OX=9913 GN=NMD3 PE=3 SV=1 CANONICAL=A0AAA9TG44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44/entry#A0AAA9SJR1-1", "sequence": { "sequence": "MEYMTDPVKHTPGHILCCDCGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWVQCALESRDLLALCLKKIKAPLSKVRLVDASFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQPQMCGDCHRVEAKDFWKAVVQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPTRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSVIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRSAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLVNCNLNDEHVNKMKSDRVPDVVLIKKSYDRTRRQRRRNWKLKELARDRENTDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSTIPVESDTDDEGAPRISLAEMLEDLHISQDATGGEGGFFTV", "length": 503, "header": "tr|A0AAA9SJR1-1|A0AAA9TG44_BOVIN Computationally mapped isoform of 60S ribosomal export protein NMD3 OS=Bos taurus OX=9913 GN=NMD3 PE=3 SV=1 CANONICAL=A0AAA9TG44-1" }, "locus": { "chromosome": "1", "start_pos": 106185883, "end_pos": 106135094, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127502.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127502.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084053.1" } ] } }, { "isoform_ac": "A0AAA9TG44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44/entry#A0AAA9TG44-1", "sequence": { "sequence": "MGDYLSSLHKTWEAFSDHKVYRKMEYMTDPVKHTPGHILCCDCGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWVQCALESRDLLALCLKKIKAPLSKVRLVDASFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQPQMCGDCHRVEAKDFWKAVVQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPTRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSVIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRSAGAGMISKKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLVNCNLNDEHVNKMKSDRVPDVVLIKKSYDRTRRQRRRNWKLKELARDRENTDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSTIPVESDTDDEGAPRISLAEMLEDLHISQDATGGEGESMMT", "length": 526, "header": "tr|A0AAA9TG44-1|A0AAA9TG44_BOVIN Isoform 1 of 60S ribosomal export protein NMD3 OS=Bos taurus OX=9913 GN=NMD3 PE=3 SV=1 CANONICAL=A0AAA9TG44-1" }, "locus": { "chromosome": "1", "start_pos": 106187429, "end_pos": 106151438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116795.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116795.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095825.1" } ] } }, { "isoform_ac": "A0AAF6Z2A6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44/entry#A0AAF6Z2A6-1", "sequence": { "sequence": "MEYMTDPVKHTPGHILCCDCGVPISPNPANICVACLRSKVDISQGIPKQVSISFCKQCQRYFQPPGTWVQCALESRDLLALCLKKIKAPLSKVRLVDASFVWTEPHSKRLKVKLTIQKEVMNGAILQQVFVVDYVVQPQMCGDCHRVEAKDFWKAVVQVRQKTLHKKTFYYLEQLILKYGMHQNTLRIKEIHDGLDFYYSSKQHAQKMVEFLQCTVPTRYKASQRLISQDIHSNTYNYKSTFSVEIVPICKDNVVCLSPKLAQSLGNMNQICVCIRVTSVIHLIDPNTLQVADIDGNTFWSHPFNSLCHPKQLEEFIVMECSIVQDIKRSAGAGMISKKIIEEFIFFPVKHTLGEVWVQKTSEMNTDKQYFCRTHLGHLLNPGDLVLGFDLVNCNLNDEHVNKMKSDRVPDVVLIKKSYDRTRRQRRRNWKLKELARDRENTDTDDERQYQDFLEDLEEDEAIRKNVNIYRDSTIPVESDTDDEGAPRISLAEMLEDLHISQDATGGEGESMMT", "length": 514, "header": "tr|A0AAF6Z2A6-1|A0AAF6Z2A6_BOVIN Computationally mapped isoform of 60S ribosomal export protein NMD3 OS=Bos taurus OX=9913 GN=NMD3 PE=3 SV=1 CANONICAL=A0AAA9TG44-1" }, "locus": { "chromosome": "1", "start_pos": 106185883, "end_pos": 106151438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021594.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021594.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021594.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021594.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "ribosomal large subunit export from nucleus", "id": "GO:0000055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000055", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "positive regulation of RNA biosynthetic process", "id": "GO:1902680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902680", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "positive regulation of protein localization to nucleolus", "id": "GO:1904751", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904751", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ribosomal large subunit binding", "id": "GO:0043023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043023", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" }, { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TG44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TG44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" }, { "id": "PF21192", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21192" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "60S ribosomal export protein NMD3 OB-fold", "eco_id": "ECO_0000259", "start_pos": 336, "end_pos": 429, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TG44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" }, { "id": "PF21193", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21193" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "60S ribosomal export protein NMD3 SH3", "eco_id": "ECO_0000259", "start_pos": 272, "end_pos": 318, "start_aa": "Ile", "end_aa": "Asp", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TG44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG44" }, { "id": "PF04981", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04981" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nmd3 N-terminal", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 269, "start_aa": "Cys", "end_aa": "Ile", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TH40-1", "uniprot_ac": "A0AAA9TH40", "uniprot_id": "A0AAA9TH40_BOVIN", "mass": { "chemical_mass": 66225.0, "monoisotopic_mass": 66225.0 }, "refseq": { "ac": "XP_005227555", "name": "apoptosis-inducing factor 1, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227555" }, "gene_names": [ { "name": "AIFM1", "type": "recommended", "evidence": [ { "id": "A0AAA9TH40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ] }, { "name": "AIFM1", "type": "synonym", "evidence": [ { "id": "XP_005227555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227555" } ] } ], "protein_names": [ { "name": "Apoptosis-inducing factor 1, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0AAA9TH40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#names_and_taxonomy" } ] }, { "name": "Programmed cell death protein 8", "type": "synonym", "evidence": [ { "id": "A0AAA9TH40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#names_and_taxonomy" } ] }, { "name": "apoptosis-inducing factor 1, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227555", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227555" } ] } ], "function": [ { "annotation": "Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence-independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40#function" }, { "database": "UniProtKB", "id": "ARBA00055744", "url": "https://www.uniprot.org/uniprotkb/ARBA00055744#function" }, { "database": "UniProtKB", "id": "E1BJA2", "url": "https://www.uniprot.org/uniprotkb/E1BJA2#function" }, { "database": "UniProtKB", "id": "A0AAA9SK02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK02#function" }, { "database": "UniProtKB", "id": "A0AAA9SP56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP56#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AIFM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40", "locus": { "chromosome": "X", "start_pos": 14056138, "end_pos": 14125897, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006838", "url": "https://www.ensembl.org/id/ENSBTAG00000006838" } ] } } ], "crossref": [ { "id": "A0AAA9TH40", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TH40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006838", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006838", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535714", "url": "https://www.ncbi.nlm.nih.gov/gene/535714", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "E1BJA2", "url": "https://www.ebi.ac.uk/intact/interactors/id:E1BJA2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR016156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029324", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BJA2", "url": "https://www.orthodb.org/?gene=E1BJA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43557", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43557", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43557:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43557:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14721", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14721", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227555", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11356", "url": "https://www.rhea-db.org/rhea/11356", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SK02", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA2", "url": "https://www.uniprot.org/uniprotkb/E1BJA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJA2-1", "url": "https://www.uniprot.org/uniprotkb/E1BJA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPVVQCHHLGPPSRSLASTGASGKDGSSLVYFLIVGATVTGAGVYYAYKTIKDDKKRYNERISGLGLTPEEKQKRATSSALEGEPEPQVRIPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEKISREVKSITIIGGGFLGSELACALGRKARASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSAGRLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASDIPVPPSNPAVPQVPTQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED", "length": 609, "header": "tr|A0AAA9TH40-1|A0AAA9TH40_BOVIN Isoform 1 of Apoptosis-inducing factor 1, mitochondrial OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=1 CANONICAL=A0AAA9TH40-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#A0AAA9SK02-1", "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPARASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSAGRLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASDIPVPPSNPAVPQVPTQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED", "length": 326, "header": "tr|A0AAA9SK02-1|A0AAA9TH40_BOVIN Computationally mapped isoform of Apoptosis-inducing factor 1, mitochondrial OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=1 CANONICAL=A0AAA9TH40-1" }, "locus": { "chromosome": "X", "start_pos": 14125712, "end_pos": 14095314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123058.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123058.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082912.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082912.1" } ] } }, { "isoform_ac": "A0AAA9SP56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#A0AAA9SP56-1", "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPGNLFQRWHVPLELQMTRQMASSGPSGGKIDNSVLVLIVGLSTIGAGAYAYKTIKDDKKRYNERISGLGLTPEEKQKRATSSALEGEPEPQVRIPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEKISREVKSITIIGGGFLGSELACALGRKARASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSAGRLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASDIPVPPSNPAVPQVPTQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKVSVGSRPLRGRPSRPLLRPGVWAPRALHPAPRSRFIRGAVVSPGICISPSNLPLAARRVGEPCASPARTSLPRRRGRSCAWPSPACSLEPGLGHRLLQFSTAPIVL", "length": 696, "header": "tr|A0AAA9SP56-1|A0AAA9TH40_BOVIN Computationally mapped isoform of Apoptosis-inducing factor 1, mitochondrial OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=1 CANONICAL=A0AAA9TH40-1" }, "locus": { "chromosome": "X", "start_pos": 14125712, "end_pos": 14056252, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115385.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115385.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088096.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088096.1" } ] } }, { "isoform_ac": "A0AAA9TFE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#A0AAA9TFE6-1", "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPGNLFQRWHVPLELQMTRQMASSGPSGGKIDNSVLVLIVGLSTIGAGAYAYKTIKDDKKRYNERISGLGLTPEEKQKRATSSALEGEPEPQVRIPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEKISREVKSITIIGGGFLGSELACALGRKAV", "length": 324, "header": "tr|A0AAA9TFE6-1|A0AAA9TFE6_BOVIN Computationally mapped isoform of Apoptosis inducing factor mitochondria associated 1 OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=1 CANONICAL=A0AAA9TH40-1" }, "locus": { "chromosome": "X", "start_pos": 14125712, "end_pos": 14102686, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097296.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097296.1" } ] } }, { "isoform_ac": "A0AAA9TH40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#A0AAA9TH40-1", "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPVVQCHHLGPPSRSLASTGASGKDGSSLVYFLIVGATVTGAGVYYAYKTIKDDKKRYNERISGLGLTPEEKQKRATSSALEGEPEPQVRIPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEKISREVKSITIIGGGFLGSELACALGRKARASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSAGRLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASDIPVPPSNPAVPQVPTQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED", "length": 609, "header": "tr|A0AAA9TH40-1|A0AAA9TH40_BOVIN Isoform 1 of Apoptosis-inducing factor 1, mitochondrial OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=1 CANONICAL=A0AAA9TH40-1" }, "locus": { "chromosome": "X", "start_pos": 14125712, "end_pos": 14095314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128493.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128493.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097845.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097845.1" } ] } }, { "isoform_ac": "E1BJA2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40/entry#E1BJA2-1", "sequence": { "sequence": "MFRCGGLAAGALKQKLAPLVRTVCVRGPRQRNRLPGNLFQRWHVPLELQMTRQMASSGPSGGKIDNSVLVLIVGLSTIGAGAYAYKTIKDDKKRYNERISGLGLTPEEKQKRATSSALEGEPEPQVRIPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPRVENGGVAVLTGKKVVQLDVRGNVAKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIEDFRTLEKISREVKSITIIGGGFLGSELACALGRKARASGTEVIQLFPEKGNMGKVLPEYLSNWTMEKVRREGVKVLPSAIVQSVGVSAGRLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSACLFGGLTTGTGIRSESETESEASDIPVPPSNPAVPQVPTQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED", "length": 622, "header": "tr|E1BJA2-1|E1BJA2_BOVIN Computationally mapped isoform of Apoptosis-inducing factor 1, mitochondrial OS=Bos taurus OX=9913 GN=AIFM1 PE=1 SV=2 CANONICAL=A0AAA9TH40-1" }, "locus": { "chromosome": "X", "start_pos": 14125712, "end_pos": 14095314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008987.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008987.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008987.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008987.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "icn3d_view": {}, "evidence": [ { "id": "28100784", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28100784" }, { "id": "A0AAA9TH40", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0AAA9TH40" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Sacoman JL, Dagda RY, Burnham-Marusich AR, Dagda RK, Berninsone PM", "evidence": [ { "database": "O-GlcNAc Database", "id": "A0AAA9TH40", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0AAA9TH40" } ], "reference": [ { "type": "PubMed", "id": "28100784", "url": "https://glygen.org/publication/PubMed/28100784" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "FAD binding", "id": "GO:0071949", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071949", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "NAD(P)H oxidase H2O2-forming activity", "id": "GO:0016174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "positive regulation of programmed cell death", "id": "GO:0043068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043068", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "protein import into mitochondrial intermembrane space", "id": "GO:0045041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045041", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex assembly", "id": "GO:0033108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033108", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" }, { "name": "mitochondrial disulfide relay system", "id": "GO:0160203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160203", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 182, "end_pos": 184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 346, "end_pos": 348, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11356", "name": "", "equation": "A + NADH + H(+) = AH2 + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7YVH9-1" ], "evidence": [ { "id": "11356", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11356" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A7YVH9", "gene_name": "PYROXD1", "activity": [ { "ec_number": "1.6.99.1", "activity": "A + NADPH + H(+) = AH2 + NADP(+).", "evidence": [ { "id": "A7YVH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVH9" } ] }, { "ec_number": "1.6.99.1", "activity": "", "evidence": [ { "id": "A7YVH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YVH9" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TH40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" }, { "id": "PF07992", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07992" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAD/NAD(P)-binding", "eco_id": "ECO_0000259", "start_pos": 132, "end_pos": 457, "start_aa": "Leu", "end_aa": "Ser", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TH40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH40" }, { "id": "PF14721", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14721" } ], "ann_type": "Domain_Extent_Annotation", 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"id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF83", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF83", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24381:SF393", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24381:SF393", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059737114", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737114", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ81", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZK6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZK6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZK6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMTVDLKVAEFSNPQIRALWETKGPVAENASQHKKHAPQTDSLSPERSHQHFRNFLYHEAAGPREVVDQLQELCRQWLRPEIHSKEQILELVVLEQFLTILPGDTQTLLKKQHPQSIEEAVVLVEHLKKETGQTRNGVAVQELGKEAVLLGEAAEAPGFQLKPAESQPVGMSLEEEVWNIHQGLQEPLSRNTHKEPEPVCERVGPAHRILAFPEQTDTKDWTVAPELVLPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYETVISLAVPAHQLLAFPKQTNTSEWTVAPELILPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYESVIFLALFVLPKPKVISCLEQGEEPWVQRPLEFKDSSEELPAAGLKLKNDTENIQSLCLSDLEIQAPVAIASRKARLKVPQKTIGKENHGDVHRVGKLHRDFPVKKKKKLSTWKQELLKLMDLQKKERAAERPFKCQECGKSFRVSSDLIKHQRVHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKGFSQKTNLHTHQRTHTGEKPFTCHECGKKFNQNCHLIKHRRTHTGEQPYTCTTCRRNFSRRSSLLRHQKLHQ", "length": 612, "header": "tr|A0AAA9TF08-1|A0AAA9TF08_BOVIN Isoform 1 of Zinc finger protein 75A OS=Bos taurus OX=9913 GN=ZNF75A PE=3 SV=2 CANONICAL=A0AAA9TF08-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08/entry#A0AAA9SNB2-1", "sequence": { "sequence": "MMTVDLKVAEFSNPQIRALWETKGPVAENASQHKKHAPQTDSLSPERSHQHFRNFLYHEAAGPREVVDQLQELCRQWLRPEIHSKEQILELVVLEQFLTILPGDTQTLLKKQHPQSIEEAVVLVEHLKKETGQTRNGVAVQELGKEAVLLGEAAEAPGFQLKPAESQPVGMSLEEEVWNIHQGLQEPLSRNTHKEPEPVCERVGPAHRILAFPEQTDTKDWTVAPELVLPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYETVISLALFVLPKPKVISCLEQGEEPWVQRPLEFKDSSEELPAAGLKLKNDTENIQSLCLSDLEIQAPVAIASRKARLKVPQKTIGKENHGDVHRVGKLHRDFPVKKKKKLSTWKQELLKLMDLQKKERAAERPFKCQECGKSFRVSSDLIKHQRVHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKGFSQKTNLHTHQRTHTGEKPFTCHECGKKFNQNCHLIKHRRTHTGEQPYTCTTCRRNFSRRSSLLRHQKLHQ", "length": 539, "header": "tr|A0AAA9SNB2-1|A0AAA9TF08_BOVIN Computationally mapped isoform of Zinc finger protein 75A OS=Bos taurus OX=9913 GN=ZNF75A PE=3 SV=2 CANONICAL=A0AAA9TF08-1" }, "locus": { "chromosome": "25", "start_pos": 2763114, "end_pos": 2755528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104432.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104432.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086829.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086829.2" } ] } }, { "isoform_ac": "A0AAA9SZ81-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08/entry#A0AAA9SZ81-1", "sequence": { "sequence": "MMTVDLKVAEFSNPQIRALWETKGPVAENASQHKKHAPQTDSLSPERSHQHFRNFLYHEAAGPREVVDQLQELCRQWLRPEIHSKEQILELVVLEQFLTILPGDTQTLLKKQHPQSIEEAVVLVEHLKKETGQTRNGVAVQELGKEAVLLGEAAEAPGFQLKPAESQPVGMSLEEEVWNIHQGLQEPLSRNTHKEPEPVCERVGPAHRILAFPEQTDTKDWTVAPELVLPESQEEWELLDPTQKALYNDVMQENYESVIFLALFVLPKPKVISCLEQGEEPWVQRPLEFKDSSEELPAAGLKLKNDTENIQSLCLSDLEIQAPVAIASRKARLKVPQKTIGKENHGDVHRVGKLHRDFPVKKKKKLSTWKQELLKLMDLQKKERAAERPFKCQECGKSFRVSSDLIKHQRVHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKGFSQKTNLHTHQRTHTGEKPFTCHECGKKFNQNCHLIKHRRTHTGEQPYTCTTCRRNFSRRSSLLRHQKLHQ", "length": 525, "header": "tr|A0AAA9SZ81-1|A0AAA9TF08_BOVIN Computationally mapped isoform of Zinc finger protein 75A OS=Bos taurus OX=9913 GN=ZNF75A PE=3 SV=2 CANONICAL=A0AAA9TF08-1" }, "locus": { "chromosome": "25", "start_pos": 2763114, "end_pos": 2755528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098432.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098432.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089392.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089392.2" } ] } }, { "isoform_ac": "A0AAA9TF08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08/entry#A0AAA9TF08-1", "sequence": { "sequence": "MMTVDLKVAEFSNPQIRALWETKGPVAENASQHKKHAPQTDSLSPERSHQHFRNFLYHEAAGPREVVDQLQELCRQWLRPEIHSKEQILELVVLEQFLTILPGDTQTLLKKQHPQSIEEAVVLVEHLKKETGQTRNGVAVQELGKEAVLLGEAAEAPGFQLKPAESQPVGMSLEEEVWNIHQGLQEPLSRNTHKEPEPVCERVGPAHRILAFPEQTDTKDWTVAPELVLPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYETVISLAVPAHQLLAFPKQTNTSEWTVAPELILPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYESVIFLALFVLPKPKVISCLEQGEEPWVQRPLEFKDSSEELPAAGLKLKNDTENIQSLCLSDLEIQAPVAIASRKARLKVPQKTIGKENHGDVHRVGKLHRDFPVKKKKKLSTWKQELLKLMDLQKKERAAERPFKCQECGKSFRVSSDLIKHQRVHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKGFSQKTNLHTHQRTHTGEKPFTCHECGKKFNQNCHLIKHRRTHTGEQPYTCTTCRRNFSRRSSLLRHQKLHQ", "length": 612, "header": "tr|A0AAA9TF08-1|A0AAA9TF08_BOVIN Isoform 1 of Zinc finger protein 75A OS=Bos taurus OX=9913 GN=ZNF75A PE=3 SV=2 CANONICAL=A0AAA9TF08-1" }, "locus": { "chromosome": "25", "start_pos": 2763114, "end_pos": 2755528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123285.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123285.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095427.2", "url": "https://www.ensembl.org/id/ENSBTAP00000095427.2" } ] } }, { "isoform_ac": "A0ABI0NZK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08/entry#A0ABI0NZK6-1", "sequence": { "sequence": "MMTVDLKVAEFSNPQIRALWETKGPVAENASQHKKHAPQTDSLSPERSHQHFRNFLYHEAAGPREVVDQLQELCRQWLRPEIHSKEQILELVVLEQFLTILPGDTQTLLKKQHPQSIEEAVVLVEHLKKETGQTRNGVAVQELGKEAVLLGEAAEAPGFQLKPAESQPVGMSLEEEVWNIHQGLQEPLSRNTHKEPEPVCERVGPAHRILAFPEQTDTKDWTVAPELVLPESQSLLTFEEVAMYFSQEEWELLDPTQKALYNDVMQENYESVIFLALFVLPKPKVISCLEQGEEPWVQRPLEFKDSSEELPAAGLKLKNDTENIQSLCLSDLEIQAPVAIASRKARLKVPQKTIGKENHGDVHRVGKLHRDFPVKKKKKLSTWKQELLKLMDLQKKERAAERPFKCQECGKSFRVSSDLIKHQRVHTEEKPYKCQQCDKRFRWSSDLNKHLTTHQGIKPYKCSWCGKGFSQKTNLHTHQRTHTGEKPFTCHECGKKFNQNCHLIKHRRTHTGEQPYTCTTCRRNFSRRSSLLRHQKLHQ", "length": 539, "header": "tr|A0ABI0NZK6-1|A0ABI0NZK6_BOVIN Computationally mapped isoform of Zinc finger protein 75A OS=Bos taurus OX=9913 GN=ZNF75A PE=3 SV=1 CANONICAL=A0AAA9TF08-1" }, "locus": { "chromosome": "25", "start_pos": 2763114, "end_pos": 2755528, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000152084.1", "url": "https://www.ensembl.org/id/ENSBTAT00000152084.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107132.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TF08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 392, "end_pos": 394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0AAA9TF08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 477, "end_pos": 504, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TF08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 236, "end_pos": 313, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": "" }, { "evidence": [ { "id": "A0AAA9TF08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF08" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 130, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": "" } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 290, "end_pos": 292 }, { "start_pos": 29, "end_pos": 31 }, { "start_pos": 392, "end_pos": 394 }, { "start_pos": 597, "end_pos": 599 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }, { "uniprot_canonical_ac": "A0AAA9TI32-1", "uniprot_ac": "A0AAA9TI32", "uniprot_id": "A0AAA9TI32_BOVIN", "mass": { "chemical_mass": 42218.0, "monoisotopic_mass": 42218.0 }, "refseq": { "ac": "XP_005206688", "name": "carbohydrate sulfotransferase 11 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206688" }, "gene_names": [ { "name": "CHST11", "type": "recommended", "evidence": [ { "id": "A0AAA9TI32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ] }, { "name": "CHST11", "type": "synonym", "evidence": [ { "id": "XP_005206688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206688" } ] } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase", "type": "recommended", "evidence": [ { "id": "A0AAA9TI32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#names_and_taxonomy" } ] }, { "name": "2.8.2.-", "type": "synonym", "evidence": [ { "id": "A0AAA9TI32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#names_and_taxonomy" } ] }, { "name": "carbohydrate sulfotransferase 11 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005206688", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206688" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32", "locus": { "chromosome": "5", "start_pos": 68307094, "end_pos": 68044326, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010644", "url": "https://www.ensembl.org/id/ENSBTAG00000010644" } ] } } ], "crossref": [ { "id": "A0AAA9TI32", "url": "https://alphafold.ebi.ac.uk/entry/A0AAA9TI32", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010644", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010644", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528860", "url": "https://www.ncbi.nlm.nih.gov/gene/528860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1N663", "url": "https://www.orthodb.org/?gene=F1N663", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12137:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12137:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03567", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03567", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005206688", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206688", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SU34", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N663", "url": "https://www.uniprot.org/uniprotkb/F1N663", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N663-1", "url": "https://www.uniprot.org/uniprotkb/F1N663-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMRRNPFGVDICCRKGSRSPLQELYNPTQRSLERVSPPWLELSNTAVLHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE", "length": 357, "header": "tr|A0AAA9TI32-1|A0AAA9TI32_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST11 PE=3 SV=1 CANONICAL=A0AAA9TI32-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SU34-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#A0AAA9SU34-1", "sequence": { "sequence": "MQHWVLICKLCDKMSILDREGGIGKFMRRNPFGVDICCRKGSRSPLQELYNPTQLELSNTAVLHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE", "length": 338, "header": "tr|A0AAA9SU34-1|A0AAA9TI32_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST11 PE=3 SV=1 CANONICAL=A0AAA9TI32-1" }, "locus": { "chromosome": "5", "start_pos": 68306544, "end_pos": 68097186, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113067.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113067.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086627.1" } ] } }, { "isoform_ac": "A0AAA9TDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#A0AAA9TDF2-1", "sequence": { "sequence": "MRLPLPRGGKESLGGTGGLERGGPRIAAPLRSPTVMRRNPFGVDICCRKGSRSPLQELYNPTQLELSNTAVLHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE", "length": 347, "header": "tr|A0AAA9TDF2-1|A0AAA9TI32_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST11 PE=3 SV=1 CANONICAL=A0AAA9TI32-1" }, "locus": { "chromosome": "5", "start_pos": 68306544, "end_pos": 68046153, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122573.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122573.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094897.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094897.1" } ] } }, { "isoform_ac": "A0AAA9TI32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#A0AAA9TI32-1", "sequence": { "sequence": "MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMRRNPFGVDICCRKGSRSPLQELYNPTQRSLERVSPPWLELSNTAVLHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE", "length": 357, "header": "tr|A0AAA9TI32-1|A0AAA9TI32_BOVIN Isoform 1 of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST11 PE=3 SV=1 CANONICAL=A0AAA9TI32-1" }, "locus": { "chromosome": "5", "start_pos": 68306544, "end_pos": 68045070, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103980.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103980.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095864.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095864.1" } ] } }, { "isoform_ac": "F1N663-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32/entry#F1N663-1", "sequence": { "sequence": "MKLAAGSTALRNSPAPQAAFSPAKRHAGGGRPPRCAHSAFWGPECGSCCSDLSWGNLRIPGLPLELSNTAVLHQMRRDQVTDTCRANSAMSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE", "length": 347, "header": "tr|F1N663-1|F1N663_BOVIN Computationally mapped isoform of Carbohydrate sulfotransferase OS=Bos taurus OX=9913 GN=CHST11 PE=3 SV=3 CANONICAL=A0AAA9TI32-1" }, "locus": { "chromosome": "5", "start_pos": 68306544, "end_pos": 68092499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014069.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014069.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014069.6", "url": "https://www.ensembl.org/id/ENSBTAP00000014069.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2022870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "resource": "Reactome", "description": "CS-GAG biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" }, { "name": "dermatan 4-sulfotransferase activity", "id": "GO:0001537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001537", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" }, { "name": "chondroitin 4-sulfotransferase activity", "id": "GO:0047756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047756", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" }, { "name": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "id": "GO:0050659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050659", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "carbohydrate biosynthetic process", "id": "GO:0016051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016051", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" }, { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TI32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1971483", "name": "CHST11,12,13,9 transfer sulfate to (4-)GalNAc", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp